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CN113049461A - Filter suction type test device and test method - Google Patents

Filter suction type test device and test method Download PDF

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Publication number
CN113049461A
CN113049461A CN201911373512.1A CN201911373512A CN113049461A CN 113049461 A CN113049461 A CN 113049461A CN 201911373512 A CN201911373512 A CN 201911373512A CN 113049461 A CN113049461 A CN 113049461A
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China
Prior art keywords
test
liquid
pressure
storage container
filter
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Chinese (zh)
Inventor
德永顺子
安部晃生
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Asahi Kasei Medical Co Ltd
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Asahi Kasei Medical Co Ltd
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Priority to CN201911373512.1A priority Critical patent/CN113049461A/en
Priority to TW109145356A priority patent/TWI780545B/en
Publication of CN113049461A publication Critical patent/CN113049461A/en
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    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/08Investigating permeability, pore-volume, or surface area of porous materials
    • G01N15/082Investigating permeability by forcing a fluid through a sample
    • G01N15/0826Investigating permeability by forcing a fluid through a sample and measuring fluid flow rate, i.e. permeation rate or pressure change
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/08Investigating permeability, pore-volume, or surface area of porous materials
    • G01N2015/084Testing filters
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/08Investigating permeability, pore-volume, or surface area of porous materials
    • G01N2015/086Investigating permeability, pore-volume, or surface area of porous materials of films, membranes or pellicules

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  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Fluid Mechanics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • External Artificial Organs (AREA)

Abstract

A filter suction test apparatus and a test method are provided. The filter (20) comprises a filter membrane, an inlet (21) and a first outlet (22). The test device comprises: a test solution storage container (10); a test liquid feed line (30) for feeding the test liquid to the primary side of the filtration membrane; a first pressure measurement means (40) for measuring the pressure in the test liquid delivery line (30); a filtrate feed line (50) for outputting the filtrate from the filter (20); a filtrate feeding pump (50P) connected to the filtrate feeding line (50) for feeding the filtrate; and a control liquid feeding mechanism (80) for feeding the control liquid into the test liquid storage container (10). The adjustment liquid feeding mechanism (80) feeds the adjustment liquid so that the differential pressure between the pressure at the liquid surface of the test liquid storage container (10) and the pressure at the measurement site of the first pressure measurement mechanism (40) is constant. So that the pressure measured by the first pressure measuring means is constant.

Description

Filter suction type test device and test method
Technical Field
The present invention relates to a suction filter, and more particularly, to a filter suction test apparatus and a test method.
Background
For example, chinese utility model CN202538643U discloses an ascites filtering and concentrating device. Ascites from a patient is collected and stored in a storage container, the ascites from the storage container is filtered by a filter to remove cell components, the ascites from which the cell components have been removed flows into a concentration filter, and water and the like are removed in the concentration filter to obtain a protein solution. The protein solution may be injected into a patient for treatment.
Also, CN109200370A discloses a body cavity fluid treatment device, which comprises a filter for filtration and a filter for concentration, and can be used for treating ascites.
For the filter, it is necessary to test its ultrafiltration performance or the like at the time of design trial production or at the time of mass production.
Disclosure of Invention
The inventors of the present invention have found that in a suction test in which a filtrate sending pump is provided on a filtrate sending line, when a test solution is sucked and sent from a test solution storage container, the liquid surface is lowered, and the pressure difference between the liquid surface of the test solution storage container and the liquid surface of a chamber for pressure measurement in the test solution sending line is increased. Since the pressure in the chamber changes according to the expanded differential pressure, the pressure value measured by a pressure gauge for measuring the pressure in the test liquid delivery line changes constantly, making it difficult to measure or estimate the pressure applied to the filter membrane in the filter.
It is to be understood that "suction" herein means that a negative pressure is applied to the outlet side of the filter to cause the test liquid to be transferred from the test liquid inlet of the filter into the filter.
An object of the present invention is to provide a filter suction test apparatus and a test method capable of easily measuring or estimating a pressure applied to a filter membrane in a filter.
Another object of the present invention is to provide a filter suction test apparatus and a test method which can be used for measuring the ultrafiltration performance of a filter and the like.
It is still another object of the present invention to provide a filter suction test apparatus and a test method for measuring the ultrafiltration performance of a filter, which can be easily performed.
It should be understood that in the filter-suction type test apparatus of the present invention, a filtrate-sending pump is provided in the filtrate-sending line downstream of the filter to suck the test liquid from the test-liquid storage container into the filter while sending the filtrate. In the test of the present invention, it is not necessary to pump the test liquid from the test liquid storage container to the filter with a liquid-sending pump between the test liquid storage container and the filter when measuring the pressure.
(claim 1) A filter suction test apparatus, wherein the filter (20) comprises a filtration membrane, an input port (21) communicating with a primary side of the filtration membrane, and a first output port (22) communicating with a secondary side of the filtration membrane and outputting a filtrate,
it is characterized in that the test device comprises:
a test solution storage container (10) for storing a test solution;
a test solution feed line (30) having one end connected to the test solution storage container (10) and the other end connected to the inlet (21) for feeding the test solution in the test solution storage container (10) to the primary side of the filtration membrane;
a first pressure measurement means (40) for measuring the pressure in the test liquid delivery line (30);
a filtrate feed line (50) having one end for connection to the first output port (22) to output filtrate from the filter (20);
a filtrate feed pump (50P) connected to the filtrate feed line (50) for feeding the filtrate; and
a conditioning liquid feeding mechanism (80) for feeding a conditioning liquid into the test liquid storage container (10),
wherein,
the adjustment liquid feeding means (80) feeds the adjustment liquid so that a differential pressure between a pressure at a liquid surface of the test liquid storage container (10) and a pressure at a measurement portion of the first pressure measurement means (40) is constant.
(embodiment 2) the test apparatus according to embodiment 1,
the test device further comprises:
the filter (20); and
a control liquid storage container (70) for storing the control liquid.
(embodiment 3) the test device according to embodiment 1 or 2,
the first pressure measurement means (40) includes:
a first pressure gauge (41);
a first chamber (42); and
a first pressure line (43) having one end connected to the first pressure gauge (41) and the other end connected to a connection terminal of the first chamber (42),
the test liquid delivery line (30) includes:
a first liquid feed line (31) having one end connected to the test liquid storage container (10) and the other end connected to an input port of the first chamber (42); and
and a second liquid feed line (32) having one end connected to the output port of the first chamber (42) and the other end connected to the input port (21) of the filter (20).
(claim 4) the test apparatus according to claim 3, wherein,
the connection terminal of the first chamber (42) is located at the upper part of the first chamber (42), the upper part of the first chamber (42) is provided with gas, the lower part of the first chamber (42) is conveyed into the test liquid,
the adjustment liquid feeding mechanism (80) feeds the adjustment liquid so that the liquid surface (11) of the test liquid storage container (10) is flush with the liquid surface (33) of the first chamber (42).
(claim 5) the test device according to claim 3 or 4, wherein,
the filter (20) is arranged with its center flush with the liquid surface (33) of the first chamber (42).
(embodiment 6) the test device according to any one of embodiments 2 to 5,
the adjustment liquid feeding mechanism (80) includes:
a control liquid feed line (81) having one end connected to the control liquid storage container (70) and the other end connected to the test liquid storage container (10); and
and a control liquid feeding pump (82) provided in the control liquid feeding line (81) and configured to feed the control liquid in the control liquid storage container (70) to the test liquid storage container (10).
(embodiment 7) the test device according to any one of embodiments 1 to 6,
the filter (20) further comprising a second outlet (23) communicating with the primary side of the filter membrane,
the test device further comprises a waste liquid conveying pipeline (90), and one end of the waste liquid conveying pipeline (90) is connected to the second output port (23) and used for outputting waste liquid.
(embodiment 8) the test apparatus according to embodiment 7, wherein,
the test device further comprises:
a waste liquid feeding pump (90P) provided in the waste liquid feeding line (90); and
and a third pressure measurement means (40B) which is provided upstream of the waste liquid feed pump (90P) and measures the pressure in the waste liquid feed line (90).
(embodiment 9) the test device according to any one of embodiments 1 to 8,
the test solution and the adjusting solution are the same solution.
(claim 10) A filter suction test apparatus, wherein the filter (20) comprises a filtration membrane, an input port (21) communicating with a primary side of the filtration membrane, and a first output port (22) communicating with a secondary side of the filtration membrane and outputting a filtrate,
it is characterized in that the test device comprises:
a test solution storage container (10) for storing a test solution;
a test solution feed line (30) having one end connected to the test solution storage container (10) and the other end connected to the inlet (21) for feeding the test solution in the test solution storage container (10) to the primary side of the filtration membrane;
a first pressure measurement means (40) for measuring the pressure in the test liquid delivery line (30);
a filtrate feed line (50) having one end for connection to the first output port (22) to output filtrate from the filter (20);
a filtrate feed pump (50P) connected to the filtrate feed line (50) for feeding the filtrate; and
and a test liquid level adjusting means (100) connected to the test liquid storage container (10) and adjusting the liquid level of the test liquid storage container (10) so that a differential pressure between the pressure at the liquid level of the test liquid storage container (10) and the pressure at the measurement portion of the first pressure measuring means (40) is constant.
(claim 11) the test apparatus according to claim 10, wherein,
the test solution liquid level adjusting mechanism (100) comprises a lifting mechanism, the test solution storage container (10) is supported on a lifting table (120) of the lifting mechanism, and the liquid level of the test solution storage container (10) is adjusted through the lifting of the lifting table (120), or
The test liquid level adjusting mechanism comprises an extruding mechanism, the test liquid storage container (10) is a liquid bag, and the liquid bag is extruded by the extruding mechanism to adjust the liquid level height in the liquid bag.
(embodiment 12) the test device according to any one of embodiments 1 to 11, wherein the filter is an ascites filter.
(claim 13) the test device according to any one of claims 1 to 12, wherein the filter (20) includes a cylindrical body, the input port (21) is provided at one axial end of the body, the first output port (22) is provided at an outer periphery of the body, and the filter (20) is provided such that a central axis of the body thereof is horizontal.
(claim 14) the test device according to any one of claims 1 to 13, further comprising a first temperature adjusting device (12), wherein the test solution storage container (10) is placed in the first temperature adjusting device (12) to be adjusted and maintained at a predetermined first temperature; and/or
The test device also comprises a second temperature regulating device (25), and the filter (20) is placed in the second temperature regulating device (25) to be regulated and maintained at a predetermined second temperature.
(scheme 15), according to the scheme 1 to 14 any of the test device, characterized in that,
the test apparatus further includes a second pressure measurement means (40A) which is provided on the upstream side of the filtrate feed pump (50P) and measures the pressure in the filtrate feed line (50).
(claim 16) A method for a filter suction test, wherein the filter (20) comprises a filtration membrane, an inlet (21) communicating with a primary side of the filtration membrane, and a first outlet (22) communicating with a secondary side of the filtration membrane for outputting a filtrate,
characterized in that the test method comprises:
drawing filtrate from the filter (20) by a filtrate drawing mechanism connected to the first output port (22) to draw a test liquid from a test liquid storage container (10) into the filter (20) via a test liquid sending line (30) to be filtered, wherein one end of the test liquid sending line (30) is connected to the test liquid storage container (10) and the other end is connected to the input port (21);
measuring the pressure in the test liquid delivery line (30) by a first pressure measuring means (40); and
the liquid level of the test liquid storage container (10) is adjusted so that the differential pressure between the pressure at the liquid level of the test liquid storage container (10) and the pressure at the measurement site of the first pressure measurement means (40) is constant.
(scheme 17), according to the scheme 16 the test method, characterized in that, the test method uses the test device of any one of schemes 1-15.
In the present invention, the control liquid feeding means feeds the control liquid to the test liquid storage container so that a differential pressure between a pressure at a liquid surface of the test liquid storage container and a pressure at a measurement portion of the first pressure measurement means is constant. In this way, the pressure measured by the first pressure measuring means is constant (i.e., remains constant), facilitating smooth testing.
Drawings
Fig. 1 shows a schematic structural view of a filter suction test apparatus according to a first embodiment of the present invention.
Fig. 2 shows a schematic structural view of a filter suction test apparatus according to a second embodiment of the present invention.
Description of the reference numerals
10 a test solution storage container, 12 a first temperature adjusting device,
20 filter, 21 input port, 22 first output port, 23 second output port, 24 liquid passing port, 25 second temperature adjusting device,
30 test liquid feed lines, 31 first liquid feed lines, 32 second liquid feed lines,
40a first pressure measuring means, 41a first pressure gauge, 42a first chamber, 43a first pressure line,
A 40A second pressure measuring mechanism, a 41A second pressure gauge, a 42A second chamber, a 43A second pressure line,
A third pressure measuring means 40B, a third pressure gauge 41B, a third chamber 42B, a third pressure line 43B,
A 50 filtrate feed line, a 50P filtrate feed pump, a 51 filtrate collection container,
70a container for the conditioning liquid,
80 adjusting liquid feeding mechanism, 81 adjusting liquid feeding pipeline, 82 adjusting liquid feeding pump,
A 90 waste liquid feeding pipeline, a 90P waste liquid feeding pump, a 91 waste liquid collecting container,
100 a test solution level adjusting mechanism, 110 a fixing part and 120 a lifting platform.
Detailed Description
Exemplary embodiments of the present invention are described below with reference to the accompanying drawings. It should be understood that the detailed description is intended only to teach one skilled in the art how to practice the invention, and is not intended to be exhaustive or to limit the scope of the invention.
< first embodiment >
As shown in FIG. 1, the present invention provides a filter suction test apparatus. Wherein the filter 20 may be an ascites filter.
It should be understood that the filter 20 may be included as part of the test device. The test device may also be used for suction testing of the filter 20 without the filter 20.
The filter 20 includes a filtration membrane, an input port 21 communicating with a primary side of the filtration membrane (e.g., the inside of the hollow fibers), and a first output port 22 communicating with a secondary side of the filtration membrane (e.g., the outside of the hollow fibers) for outputting a filtrate. The filter 20 may further include: a second outlet 23 communicating with the primary side of the filtration membrane for outputting a waste liquid; and another liquid through port 24 which communicates with the secondary side of the filtration membrane and which can be closed in this test. It should be understood that the filter membrane herein is not limited to a thin membrane, but may be a filter element in the form of including a hollow fiber membrane or the like.
The test device may include: a test solution storage container 10 for storing a test solution; a test solution feed line 30 having one end connected to the test solution storage container 10 and the other end connected to the inlet port 21 for feeding the test solution in the test solution storage container 10 to the primary side of the filtration membrane; a first pressure measuring means 40 for measuring the pressure in the test liquid feed line 30; a filtrate feed line 50 having one end connected to the first output port 22 to output the filtrate from the filter 20; a filtrate feed pump 50P connected to the filtrate feed line 50, and particularly provided in the filtrate feed line 50 for feeding the filtrate; and a control liquid feeding mechanism 80 for feeding the control liquid into the test liquid storage container 10.
The test apparatus may further include a conditioning liquid storage tank 70 for storing a conditioning liquid. The control liquid feeding mechanism 80 is for feeding the control liquid in the control liquid storage container 70 to the test liquid storage container 10.
Here, the control liquid feeding mechanism 80 feeds the control liquid so that a differential pressure between the pressure at the liquid surface 11 of the test liquid storage container 10 and the pressure at the measurement site of the first pressure measurement mechanism 40 is constant.
Since the liquid surface 11 in the test liquid storage container 10 is lowered as the test liquid is sucked into the filter 20, the pressure at the measurement portion of the first pressure measurement means 40 is constantly changed, and the changed pressure makes the test difficult to be smoothly performed. In the present invention, the control liquid feeding mechanism 80 feeds the control liquid to the test liquid storage container 10 so that a differential pressure between the pressure at the liquid surface 11 of the test liquid storage container 10 and the pressure at the measurement portion of the first pressure measurement mechanism 40 is constant. In this way, the pressure measured by the first pressure measuring means 40 is constant (i.e., remains constant), facilitating smooth testing.
Preferably, the control liquid feeding mechanism 80 may feed the control liquid so that the position of the liquid surface 11 of the test liquid storage container 10 is kept constant.
The first pressure measuring mechanism 40 may include a first pressure gauge 41, a first chamber 42, and a first pressure line 43. The first pressure line 43 has one end connected to the first pressure gauge 41 and the other end connected to a connection terminal of the first chamber 42.
The test liquid feed line 30 may include: a first liquid feeding line 31 having one end connected to the test liquid storage container 10 and the other end connected to an input port of the first chamber 42; and a second liquid feeding line 32 having one end connected to the output port of the first chamber 42 and the other end connected to the input port 21 of the filter 20.
The connection terminal of the first chamber 42 may be located at the upper portion, particularly the upper end, in the vertical direction of the first chamber 42, but may be located at any other position of the upper portion of the first chamber 42. The upper part of the first chamber 42 may have a gas such as air, and the lower part of the first chamber 42 in the vertical direction sucks in the test liquid. More specifically, the first liquid sending line 31 inputs the test liquid from the input port of the first chamber 42 to the first chamber 42. The test liquid is sucked into the filter 20 from the output port of the first chamber 42 through the second liquid feed line 32.
Here, the control liquid feeding mechanism 80 preferably feeds the control liquid so that the liquid surface 11 of the test liquid storage container 10 is flush with the liquid surface 33 of the first chamber 42. Of course, there may be a height difference between the liquid level 11 of the test liquid storage container 10 and the liquid level 33 of the first chamber 42, but the height difference, if any, is preferably constant.
Preferably, the filter 20 is arranged with its center flush with the liquid surface 33 of the first chamber 42.
Since the pressure of the enclosed gas in the first chamber 42 is substantially equal to the pressure at the liquid level 33 (the gas transmits the pressure at the liquid level 33 to the first pressure gauge 41), and the liquid level 33 is flush with the center of the filter 20, the pressure measured by the first pressure gauge 41 is substantially equal to the pressure to which the filter membrane is subjected, so that the pressure to which the filter membrane is subjected can be easily obtained.
In this embodiment, the measurement site of the first pressure measurement means 40 is the liquid level 33, and the liquid level 33 is a site directly measured by the first pressure measurement means 40 or the first pressure gauge 41 without using air.
In the present invention, by providing the first chamber 42, the pressure of the gas enclosed in the first chamber 42 is measured, and thus, the first pressure gauge 41 does not have to be in contact with the test solution, and thus, the test solution can be prevented from contaminating the first pressure gauge 41, so that the first pressure gauge 41 can be easily reused, which reduces the test cost.
The adjustment liquid feeding mechanism 80 may include: a control liquid feed line 81 having one end connected to the control liquid storage container 70 and the other end connected to the test liquid storage container 10; and a control liquid feeding pump 82 provided in the control liquid feeding line 81 for feeding the control liquid in the control liquid storage container 70 to the test liquid storage container 10. At least in the steady test stage, the conditioning liquid feed pump 82 can be continuously operated so as to keep the position of the liquid surface 11 of the test liquid storage container 10 constant. It should be understood that the liquid sending pump mentioned in this application is provided in the liquid sending line, and the liquid sending pump can be embodied as connecting two liquid sending lines together.
The test device may further include a waste liquid sending line 90, and one end of the waste liquid sending line 90 is connected to the second output port 23 of the filter 20, thereby outputting waste liquid.
Here, the test solution and the conditioning solution may be the same solution, which makes the test simpler to run. However, the present invention is not limited to this, and for example, the test solution and the control solution may be two liquids having different densities and being immiscible with each other, so that the liquid fed to the filter 20 is always the test solution, and the control solution is used only for controlling the liquid level 11 of the test solution storage container 10.
The filter 20 may include a cylindrical body, and the input port 21 may be provided at one axial end of the body and the second output port 23 may be provided at the other axial end of the body. The first output port 22 and the liquid passage port 24 may be provided on the outer periphery of the main body, and in the present test mode, extend from the outer periphery of the main body. Here, it is preferable that the filter 20 is disposed in such a manner that the central axis of the body thereof is horizontal. For example, where the filtration membrane comprises hollow fibers, the pressure at the central axis of the body of the filter 20 may be representative of the pressure to which the filtration membrane is subjected. This arrangement of the filter 20 makes it easier to accurately obtain the pressure to which the filter membrane is subjected. It should be understood that the filter 20 may also be positioned substantially vertically.
Alternatively, the test apparatus may further include a first temperature adjusting device 12, and the test solution storage container 10 is placed in the first temperature adjusting device 12 such that the test solution in the test solution storage container 10 is adjusted and maintained at a predetermined first temperature. The first temperature is, for example, 37 degrees of the body temperature of a human being. The first temperature adjustment device 12 may be a constant temperature bath containing a liquid in which the test solution storage container 10 is disposed.
Optionally, the test device may further comprise a second temperature adjustment device 25, the filter 20 being conditioned and maintained at a predetermined second temperature by being placed in the second temperature adjustment device 25. The second temperature is, for example, 37 degrees of the body temperature of a human being. The second temperature adjustment means 25 may be a thermostatic bath containing a liquid in which the filter 20 is disposed.
Therefore, the temperature of the test solution can be close to the body temperature of a human body, and the use condition of a real ascites filter can be simulated conveniently.
The test apparatus may further include a second pressure measurement mechanism 40A provided on the upstream side of the filtrate feed pump 50P for measuring the pressure in the filtrate feed line 50. Similar to the first pressure measurement mechanism 40, the second pressure measurement mechanism 40A may include a second pressure gauge 41A, a second chamber 42A, and a second pressure line 43A. Since the second pressure measuring mechanism 40A is similar to the first pressure measuring mechanism 40, a detailed description thereof will not be given here.
Similar to test fluid delivery line 30, the filtrate delivery line 50 may include two fluid delivery lines, with the second chamber 42A connecting the two fluid delivery lines together. The filtrate (the test liquid after filtering out undesired remaining components) outputted from the filtrate sending line 50 may be collected in the filtrate collecting container 51, sampled and measured.
The test device may further comprise: a waste liquid feeding pump 90P provided in the waste liquid feeding line 90 for feeding waste liquid; and a third pressure measuring means 40B provided upstream of the waste liquid feeding pump 90P for measuring the pressure in the waste liquid feeding line 90.
Similar to the first pressure measurement mechanism 40, the third pressure measurement mechanism 40B may include a third pressure gauge 41B, a third chamber 42B, and a third pressure line 43B. Since the third pressure measuring mechanism 40B is similar to the first pressure measuring mechanism 40, a detailed description thereof will not be given here.
Similar to test solution delivery line 30, waste solution delivery line 90 may include two delivery lines, with third chamber 42B connecting the two delivery lines together. The waste liquid (filtered out undesired remaining components) output from the waste liquid sending line 90 may be collected into the waste liquid collecting container 91.
Here, the liquid-feeding pumps 82, 50P, and 90P may be roller pumps (roller pumps).
< second embodiment >
Fig. 2 shows a filter suction test apparatus according to a second embodiment of the present invention. The same or similar components as those of the first embodiment are denoted by the same reference numerals, and detailed description thereof is omitted. The following mainly explains differences of the second embodiment from the first embodiment.
In the first embodiment, the position of the liquid surface 11 of the test liquid storage container 10 is adjusted by feeding the control liquid in the control liquid storage container 70 to the test liquid storage container 10 by the control liquid feeding mechanism 80. Therefore, the control liquid storage container 70 and the control liquid feeding mechanism 80 may constitute a test liquid level adjusting mechanism.
In the second embodiment, another type of test liquid level adjusting mechanism is used, which is connected to the test liquid storage container 10 and adjusts the liquid level 11 of the test liquid storage container 10 so that a differential pressure between the pressure at the liquid level 11 of the test liquid storage container 10 and the pressure at the measurement portion of the first pressure measuring mechanism 40 is constant. In particular, the test solution level adjustment mechanism adjusts the height and/or position and/or shape of the test solution storage container 10 so that the position of the liquid surface 11 of the test solution storage container 10 is kept constant (height is not changed).
In one example, as shown in fig. 2, the test solution level adjustment mechanism 100 may include an elevating mechanism including a fixing portion 110 and an elevating table 120. The test solution storage container 10 is supported by a lift table 120 of a lift mechanism, and the height of the liquid surface 11 of the test solution storage container 10 is adjusted by the lift of the lift table 120. The lifting platform can be lifted manually or electrically.
In another example, the test liquid level adjustment mechanism may include a squeezing mechanism, and the test liquid storage container 10 may be a liquid bag, and the liquid level in the liquid bag is adjusted by squeezing the liquid bag by the squeezing mechanism.
The invention also provides a filter suction test method which can use the test device according to the invention.
The test method comprises the following steps: a filtrate suction mechanism (for example, a filtrate feed pump 50P) connected to the first output port 22 draws the filtrate from the filter 20, and the test solution is sucked into the filter 20 from the test solution storage container 10 through the test solution feed line 30 and filtered; the pressure in the test liquid feed line 30 is measured by the first pressure measuring means 40; and adjusting the position of the liquid surface 11 of the test liquid storage container 10 so that a differential pressure between the pressure at the liquid surface 11 of the test liquid storage container 10 and the pressure at the measurement portion of the first pressure measurement means 40 is constant.
It will be appreciated that the various structures, steps and functions described above for the assay device are equally applicable to the assay method.
The pressure difference between the membranes (also referred to as "transmembrane pressure difference") of the filtration membrane can be calculated from the pressures measured by the first pressure measuring means 40, the second pressure measuring means 40A, and the third pressure measuring means 40B, and can be used to calculate the ultrafiltration performance of the filter. The test apparatus and the test method of the present invention can stably measure the pressure by the first pressure measuring means 40, and thus can easily perform the ultrafiltration performance test.
In one example, the transmembrane pressure difference TMP is (pressure on the inlet side of the filter + pressure on the outlet side of the filter)/2-filtrate side pressure.
The pressure measured by the first pressure measuring means 40 may be set as the pressure on the inlet side of the filter, the pressure measured by the second pressure measuring means 40A may be set as the filtrate side pressure, and the pressure measured by the third pressure measuring means 40B may be set as the pressure on the outlet side of the filter.
It should be understood that the test apparatus and test method of the present invention are not limited to the measurement of ultrafiltration performance, for example, the test apparatus and test method of the present invention may also be used to measure the rejection rate of the filter 20.
It should be understood that the above embodiments are only exemplary and are not intended to limit the present invention. Various modifications and alterations of the above-described embodiments may be made by those skilled in the art in light of the teachings of the present invention without departing from the scope thereof.

Claims (17)

1. A filter suction test apparatus, the filter (20) comprising a filtration membrane, an input port (21) communicating with a primary side of the filtration membrane, and a first output port (22) communicating with a secondary side of the filtration membrane for outputting a filtrate,
it is characterized in that the test device comprises:
a test solution storage container (10) for storing a test solution;
a test solution feed line (30) having one end connected to the test solution storage container (10) and the other end connected to the inlet (21) for feeding the test solution in the test solution storage container (10) to the primary side of the filtration membrane;
a first pressure measurement means (40) for measuring the pressure in the test liquid delivery line (30);
a filtrate feed line (50) having one end for connection to the first output port (22) to output filtrate from the filter (20);
a filtrate feed pump (50P) connected to the filtrate feed line (50) for feeding the filtrate; and
a conditioning liquid feeding mechanism (80) for feeding a conditioning liquid into the test liquid storage container (10),
wherein,
the adjustment liquid feeding means (80) feeds the adjustment liquid so that a differential pressure between a pressure at a liquid surface of the test liquid storage container (10) and a pressure at a measurement portion of the first pressure measurement means (40) is constant.
2. Testing device according to claim 1,
the test device further comprises:
the filter (20); and
a control liquid storage container (70) for storing the control liquid.
3. Testing device according to claim 1 or 2,
the first pressure measurement means (40) includes:
a first pressure gauge (41);
a first chamber (42); and
a first pressure line (43) having one end connected to the first pressure gauge (41) and the other end connected to a connection terminal of the first chamber (42),
the test liquid delivery line (30) includes:
a first liquid feed line (31) having one end connected to the test liquid storage container (10) and the other end connected to an input port of the first chamber (42); and
and a second liquid feed line (32) having one end connected to the output port of the first chamber (42) and the other end connected to the input port (21) of the filter (20).
4. Testing device according to claim 3,
the connection terminal of the first chamber (42) is located at the upper part of the first chamber (42), the upper part of the first chamber (42) is provided with gas, the lower part of the first chamber (42) is conveyed into the test liquid,
the adjustment liquid feeding mechanism (80) feeds the adjustment liquid so that the liquid surface (11) of the test liquid storage container (10) is flush with the liquid surface (33) of the first chamber (42).
5. Testing device according to claim 3 or 4,
the filter (20) is arranged with its center flush with the liquid surface (33) of the first chamber (42).
6. Test device according to one of the claims 2 to 5,
the adjustment liquid feeding mechanism (80) includes:
a control liquid feed line (81) having one end connected to the control liquid storage container (70) and the other end connected to the test liquid storage container (10); and
and a control liquid feeding pump (82) provided in the control liquid feeding line (81) and configured to feed the control liquid in the control liquid storage container (70) to the test liquid storage container (10).
7. Test device according to one of the claims 1 to 6,
the filter (20) further comprising a second outlet (23) communicating with the primary side of the filter membrane,
the test device further comprises a waste liquid conveying pipeline (90), and one end of the waste liquid conveying pipeline (90) is connected to the second output port (23) and used for outputting waste liquid.
8. The test device according to claim 7,
the test device further comprises:
a waste liquid feeding pump (90P) provided in the waste liquid feeding line (90); and
and a third pressure measurement means (40B) which is provided upstream of the waste liquid feed pump (90P) and measures the pressure in the waste liquid feed line (90).
9. Testing device according to any of claims 1 to 8,
the test solution and the adjusting solution are the same solution.
10. A filter suction test apparatus, the filter (20) comprising a filtration membrane, an input port (21) communicating with a primary side of the filtration membrane, and a first output port (22) communicating with a secondary side of the filtration membrane for outputting a filtrate,
it is characterized in that the test device comprises:
a test solution storage container (10) for storing a test solution;
a test solution feed line (30) having one end connected to the test solution storage container (10) and the other end connected to the inlet (21) for feeding the test solution in the test solution storage container (10) to the primary side of the filtration membrane;
a first pressure measurement means (40) for measuring the pressure in the test liquid delivery line (30);
a filtrate feed line (50) having one end for connection to the first output port (22) to output filtrate from the filter (20);
a filtrate feed pump (50P) connected to the filtrate feed line (50) for feeding the filtrate; and
and a test liquid level adjusting means (100) connected to the test liquid storage container (10) and adjusting the liquid level of the test liquid storage container (10) so that a differential pressure between the pressure at the liquid level of the test liquid storage container (10) and the pressure at the measurement portion of the first pressure measuring means (40) is constant.
11. Testing device according to claim 10,
the test solution liquid level adjusting mechanism (100) comprises a lifting mechanism, the test solution storage container (10) is supported on a lifting table (120) of the lifting mechanism, and the liquid level of the test solution storage container (10) is adjusted through the lifting of the lifting table (120), or
The test liquid level adjusting mechanism comprises an extruding mechanism, the test liquid storage container (10) is a liquid bag, and the liquid bag is extruded by the extruding mechanism to adjust the liquid level height in the liquid bag.
12. The test device of any one of claims 1 to 11, wherein the filter is an ascites filter.
13. Test device according to any of claims 1 to 12, characterized in that the filter (20) comprises a cylindrical body, the inlet (21) being arranged at one axial end of the body, the first outlet (22) being arranged at the periphery of the body, the filter (20) being arranged with the central axis of its body horizontal.
14. The testing device according to any one of claims 1 to 13, further comprising a first temperature adjusting device (12), wherein the test solution storage container (10) is placed in the first temperature adjusting device (12) to be adjusted and maintained at a predetermined first temperature; and/or
The test device also comprises a second temperature regulating device (25), and the filter (20) is placed in the second temperature regulating device (25) to be regulated and maintained at a predetermined second temperature.
15. Test device according to one of the claims 1 to 14,
the test apparatus further includes a second pressure measurement means (40A) which is provided on the upstream side of the filtrate feed pump (50P) and measures the pressure in the filtrate feed line (50).
16. A filter suction test method, the filter (20) comprises a filter membrane, an input port (21) communicated with the primary side of the filter membrane, and a first output port (22) communicated with the secondary side of the filter membrane and used for outputting filtrate,
characterized in that the test method comprises:
drawing filtrate from the filter (20) by a filtrate drawing mechanism connected to the first output port (22) to draw a test liquid from a test liquid storage container (10) into the filter (20) via a test liquid sending line (30) to be filtered, wherein one end of the test liquid sending line (30) is connected to the test liquid storage container (10) and the other end is connected to the input port (21);
measuring the pressure in the test liquid delivery line (30) by a first pressure measuring means (40); and
the liquid level of the test liquid storage container (10) is adjusted so that the differential pressure between the pressure at the liquid level of the test liquid storage container (10) and the pressure at the measurement site of the first pressure measurement means (40) is constant.
17. The test method according to claim 16, wherein the test device according to any one of claims 1 to 15 is used.
CN201911373512.1A 2019-12-27 2019-12-27 Filter suction type test device and test method Pending CN113049461A (en)

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CN201911373512.1A CN113049461A (en) 2019-12-27 2019-12-27 Filter suction type test device and test method
TW109145356A TWI780545B (en) 2019-12-27 2020-12-21 Filter test device and test method

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Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2410351A1 (en) * 2000-06-23 2002-01-03 Scilog, Inc. Enhancing filtration yields in tangential flow filtration
US20020043487A1 (en) * 2000-06-23 2002-04-18 Schick Karl G. Method and apparatus for enhancing filtration yields in tangential flow filtration
JP2009276487A (en) * 2008-05-14 2009-11-26 Jsr Corp Method for producing resist resin-containing solution, resist resin-containing solution, and filtering apparatus
CN104520691A (en) * 2012-06-14 2015-04-15 生物辐射实验室股份有限公司 Flow rate balanced, dynamically adjustable sheath delivery system for flow cytometry
CN206549458U (en) * 2017-02-21 2017-10-13 山东金朗生物科技有限公司 A kind of L alanine fermentation liquid constant-pressure enters film device
CN108744183A (en) * 2018-06-29 2018-11-06 中国人民解放军第五三中心医院 A kind of liquid level controllable type supersonic atomizing inhalator
CN208935513U (en) * 2018-09-25 2019-06-04 天津博威动力设备有限公司 Pipeline positive pressure keeps normally closed equipment

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2410351A1 (en) * 2000-06-23 2002-01-03 Scilog, Inc. Enhancing filtration yields in tangential flow filtration
US20020043487A1 (en) * 2000-06-23 2002-04-18 Schick Karl G. Method and apparatus for enhancing filtration yields in tangential flow filtration
JP2009276487A (en) * 2008-05-14 2009-11-26 Jsr Corp Method for producing resist resin-containing solution, resist resin-containing solution, and filtering apparatus
CN104520691A (en) * 2012-06-14 2015-04-15 生物辐射实验室股份有限公司 Flow rate balanced, dynamically adjustable sheath delivery system for flow cytometry
CN206549458U (en) * 2017-02-21 2017-10-13 山东金朗生物科技有限公司 A kind of L alanine fermentation liquid constant-pressure enters film device
CN108744183A (en) * 2018-06-29 2018-11-06 中国人民解放军第五三中心医院 A kind of liquid level controllable type supersonic atomizing inhalator
CN208935513U (en) * 2018-09-25 2019-06-04 天津博威动力设备有限公司 Pipeline positive pressure keeps normally closed equipment

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