CN112987816A - Chip temperature control system and chip temperature control device thereof - Google Patents
Chip temperature control system and chip temperature control device thereof Download PDFInfo
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- CN112987816A CN112987816A CN202110217605.6A CN202110217605A CN112987816A CN 112987816 A CN112987816 A CN 112987816A CN 202110217605 A CN202110217605 A CN 202110217605A CN 112987816 A CN112987816 A CN 112987816A
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- G05D23/19—Control of temperature characterised by the use of electric means
- G05D23/20—Control of temperature characterised by the use of electric means with sensing elements having variation of electric or magnetic properties with change of temperature
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Abstract
The invention discloses a chip temperature control system and a chip temperature control device thereof, wherein the chip temperature control device comprises: the device comprises a centrifugal micro-fluidic chip, a heating device, a driving device for driving a reaction tank of the centrifugal micro-fluidic chip to be close to or far away from the heating device, a temperature measuring device for detecting the temperature of liquid in the reaction tank and a temperature control device, wherein the heating device can penetrate through a shell of the centrifugal micro-fluidic chip to directly heat the liquid, and the heating device and the temperature measuring device are both connected with the temperature control device. The heating device can penetrate through the shell of the centrifugal microfluidic chip to directly heat the liquid, and the temperature measuring device can effectively detect the temperature of the liquid in the reaction tank and transmit the temperature measuring signal to the temperature control device, so that the temperature control device can control the heating device to operate, and the constant temperature control of the liquid is realized. Because the heating device of the device can directly heat the liquid, the liquid can be ensured to be heated up rapidly, and then the energy utilization rate of the heating device is improved and the energy consumption is reduced.
Description
Technical Field
The invention relates to the technical field of microfluidics, in particular to a chip temperature control device. In addition, still relate to a chip temperature control system including above-mentioned chip temperature control device.
Background
Compared with the chips adopting pressure drive, electric drive and other types, the centrifugal micro-fluidic chip does not need to be provided with a large-scale liquid pumping and sampling system outside the chip, does not need high-voltage and high-power equipment, and effectively overcomes the difficulty of a driving device in the aspect of integration. Meanwhile, the centrifugal microfluidic chip can realize high-density integration of sample pretreatment functions such as centrifugal separation, quantitative extraction and the like, and avoids dependence on laboratory macro instruments and loss and pollution generated in the transfer process of samples. Therefore, the centrifugal microfluidic chip is easier to realize miniaturization, portability, and automation of the microfluidic analysis system than other types of microfluidic chips. Therefore, centrifugal microfluidic chips are widely used in the fields of analytical chemistry, immunological diagnosis, protein analysis, molecular diagnosis, food, water, soil analysis, and the like.
In the application process of the centrifugal microfluidic chip, some reactions need to be carried out at a specific temperature, so that temperature control is one of the keys for ensuring the accuracy of the analysis result of the microfluidic chip system. When the centrifugal micro-fluidic chip is used, the centrifugal micro-fluidic chip is driven by a motor to rotate at a high speed, and when the temperature of the chip is controlled, the centrifugal micro-fluidic chip is usually carried out in an air bath mode, the air bath heats air in a cavity where the micro-fluidic chip is located so as to indirectly heat the chip and internal liquid, and further, the temperature of the air in the cavity where the chip is located is kept stable so as to stabilize the temperature of the liquid in the chip. However, since the centrifugal microfluidic chip is usually made of polymer, when the hot air indirectly heats the internal liquid through the polymer chip with poor heat conduction, the centrifugal microfluidic chip has the defects of high power consumption, low energy utilization rate, low temperature rise speed and the like.
In summary, how to improve the temperature control effect of the centrifugal microfluidic chip is a problem to be solved urgently by those skilled in the art.
Disclosure of Invention
In view of the above, an object of the present invention is to provide a chip temperature control apparatus, which can effectively improve the temperature control effect of a centrifugal microfluidic chip, improve the energy utilization rate of the apparatus, and effectively reduce energy consumption.
Another object of the present invention is to provide a chip temperature control system including the above chip temperature control device.
In order to achieve the above purpose, the invention provides the following technical scheme:
a chip temperature control apparatus, comprising: the device comprises a centrifugal micro-fluidic chip, a heating device, a driving device for driving a reaction tank of the centrifugal micro-fluidic chip to be close to or far away from the heating device, a temperature measuring device for detecting the temperature of liquid in the reaction tank and a temperature control device, wherein the heating device can penetrate through a shell of the centrifugal micro-fluidic chip to directly heat the liquid, and the heating device and the temperature measuring device are both connected with the temperature control device.
Preferably, the driving device includes a fixing device for axially fixing the centrifugal microfluidic chip and a motor for driving the centrifugal microfluidic chip to rotate, the centrifugal microfluidic chip is sleeved on an outer periphery of an output shaft of the motor, and the heating device and the temperature measuring device are both arranged on the fixing device.
Preferably, the heating device is an infrared focusing heater.
Preferably, the working light of the infrared focusing heater has a wave number range of 3600cm-1-2800cm-1Or 1000cm-1-1800cm-1A single wavelength or a combination of a plurality of said wavelengths.
Preferably, the temperature measuring device is an infrared temperature sensor.
Preferably, the fixing device includes a hollow-out portion for fixing the infrared focusing heater and the infrared temperature sensor.
Preferably, the distance between the infrared focusing heater and the center of the centrifugal microfluidic chip is equal to the distance between the infrared temperature sensor and the center, and the positions of the infrared focusing heater and the infrared temperature sensor are not overlapped.
Preferably, the angular separation of the infrared focusing heater and the infrared temperature sensor is greater than 10 °.
Preferably, the temperature control device performs temperature control operation on the liquid through a temperature control algorithm, wherein the temperature control algorithm is a PID algorithm, a fuzzy PID algorithm or a neural network control algorithm.
A chip temperature control system comprises a temperature control device and a main control device, wherein the temperature control device is any one of the chip temperature control devices, and the driving device and the temperature control device are connected with the main control device.
When the chip temperature control device provided by the invention is used, the driving device can drive the reaction tank of the centrifugal micro-fluidic chip to be close to or far away from the heating device, when the reaction tank is close to the heating device, the heating device can penetrate through the shell of the centrifugal micro-fluidic chip to directly heat liquid, when the reaction tank is far away from the heating device, the heating operation of the liquid is stopped, the temperature measuring device is also convenient to effectively detect the temperature of the liquid in the reaction tank, and the temperature measuring device can transmit the temperature measuring signal to the temperature control device, so that the temperature control device can control the heating device to operate, and the constant temperature control of the liquid is realized. Because the heating device of the device can directly heat the liquid, the liquid can be ensured to be heated up rapidly, and then the energy utilization rate of the heating device is improved and the energy consumption is reduced.
In conclusion, the chip temperature control device provided by the invention can effectively improve the temperature control effect of the centrifugal micro-fluidic chip and improve the energy utilization rate of the device.
In addition, the invention also provides a chip temperature control system comprising the chip temperature control device.
Drawings
In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings used in the description of the embodiments or the prior art will be briefly described below, it is obvious that the drawings in the following description are only embodiments of the present invention, and for those skilled in the art, other drawings can be obtained according to the provided drawings without creative efforts.
FIG. 1 is a schematic structural diagram of a chip temperature control device according to the present invention;
FIG. 2 is a cross-sectional view of FIG. 1;
FIG. 3 is a schematic view of the distribution of a plurality of heating devices and temperature measuring devices.
In fig. 1-3:
1 is a centrifugal micro-fluidic chip, 2 is a heating device, 3 is a driving device, 31 is a fixing device, 32 is a motor, 4 is a temperature measuring device, 5 is a hollow part, and 6 is a reaction tank.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
The core of the invention is to provide a chip temperature control device, which can effectively improve the temperature control effect of a centrifugal micro-fluidic chip and improve the energy utilization rate of the device. The other core of the invention is to provide a chip temperature control system comprising the chip temperature control device.
Referring to fig. 1 to 3, fig. 1 is a schematic structural diagram of a chip temperature control device according to the present invention; FIG. 2 is a cross-sectional view of FIG. 1; FIG. 3 is a schematic view of the distribution of a plurality of heating devices and temperature measuring devices.
This embodiment provides a chip temperature control apparatus, including: the device comprises a centrifugal micro-fluidic chip 1, a heating device 2, a driving device 3 for driving a reaction tank 6 of the centrifugal micro-fluidic chip 1 to be close to or far away from the heating device 2, a temperature measuring device 4 for detecting the temperature of liquid in the reaction tank 6 and a temperature control device, wherein the heating device 2 can penetrate through a shell of the centrifugal micro-fluidic chip 1 to directly heat the liquid, and the heating device 2 and the temperature measuring device 4 are connected with the temperature control device.
It should be noted that, the heating device 2 may be configured as an infrared heater to directly heat the liquid by infrared rays, so as to improve the energy utilization rate of the heating device 2 and the temperature rising speed of the liquid, and facilitate the temperature control device to accurately control the heating process and the constant temperature control process of the liquid.
In the actual application process, the shapes, structures, sizes, materials, positions and the like of the centrifugal micro-fluidic chip 1, the heating device 2, the driving device 3, the temperature measuring device 4 and the temperature control device can be determined according to actual conditions and actual requirements.
When the chip temperature control device provided by the invention is used, the driving device 3 can drive the reaction tank 6 of the centrifugal micro-fluidic chip 1 to be close to or far from the heating device 2, when the reaction tank 6 is close to the heating device 2, the heating device 2 can penetrate through the shell of the centrifugal micro-fluidic chip 1 to directly heat liquid, when the reaction tank 6 is far from the heating device 2, the heating operation of the liquid is stopped, the temperature measuring device 4 is also convenient to effectively detect the temperature of the liquid in the reaction tank 6, the temperature measuring device 4 can transmit the temperature measuring signal to the temperature control device, so that the temperature control device can control the operation of the heating device 2, and the constant temperature control of the liquid is realized. Because the heating device 2 of the device can directly heat the liquid, the liquid can be ensured to be heated up rapidly, and then the energy utilization rate of the heating device 2 is improved and the energy consumption is reduced.
In conclusion, the chip temperature control device provided by the invention can effectively improve the temperature control effect of the centrifugal micro-fluidic chip 1 and improve the energy utilization rate of the device.
On the basis of the above embodiment, it is preferable that the driving device 3 includes a fixing device 31 for axially fixing the centrifugal microfluidic chip 1 and a motor 32 for driving the centrifugal microfluidic chip 1 to rotate, the centrifugal microfluidic chip 1 is sleeved on the outer periphery of the output shaft of the motor 32, and the heating device 2 and the temperature measuring device 4 are both disposed on the fixing device 31.
It should be noted that, the centrifugal microfluidic chip 1 is a structure similar to a CD disc, an output shaft of the motor 32 can be arranged at the center of the centrifugal microfluidic chip 1, the heating device 2 and the temperature measuring device 4 are arranged above the centrifugal microfluidic chip 1, and when the motor 32 rotates and operates, the centrifugal microfluidic chip 1 can be driven to rotate, so that the plurality of reaction cells 6 uniformly distributed along the circumferential direction of the centrifugal microfluidic chip 1 sequentially appear below the heating device 2 and the temperature measuring device 4.
Preferably, the heating device 2 is an infrared focusing heater, and the infrared focusing heater may be driven by a PWM signal.
It should be noted that the infrared focusing heater is used to focus energy inside the centrifugal microfluidic chip 1, and the infrared focusing heater can directly heat the liquid in the reaction tank 6 under the control of the temperature control device.
Preferably, the working light of the infrared focusing heater is in the wave number range of 3600cm-1-2800cm-1Or 1000cm-1-1800cm-1A single wavelength or a combination of multiple wavelengths.
It should be noted that the operating light has a wave number in the range of 3600cm-1-2800cm-1Or 1000cm-1-1800cm-1The working wavelength of the infrared focusing heater is within the wavelength range of the absorption peak of PMMA or water, so that the heating effect of the infrared focusing heater on liquid can be effectively improved. The wavelength of the infrared focusing heater can be determined according to actual conditions and actual requirements in the actual application process.
Preferably, the temperature measuring device 4 is an infrared temperature sensor, and the infrared temperature sensor is used for monitoring the temperature of the liquid in the reaction tank 6 in real time and feeding back a liquid temperature signal to the temperature control device.
Preferably, the fixing means 31 comprise a hollowed-out portion 5 for fixing the infrared focusing heater and the infrared temperature sensor. That is, the fixing device 31 may be provided with a hollow portion 5, so that the infrared focusing heater and the infrared temperature sensor are fixed above the centrifugal microfluidic chip 1, an opening of the infrared focusing heater for emitting infrared rays may pass through the hollow portion 5, so that the infrared rays are directly irradiated on the centrifugal microfluidic chip 1, and a probe of the infrared temperature sensor may also pass through the hollow portion 5, so that the infrared temperature sensor directly receives the infrared rays emitted by the fluid, and further detects the actual temperature of the fluid.
Preferably, the distance between the infrared focusing heater and the center of the centrifugal microfluidic chip 1 is equal to the distance between the infrared temperature sensor and the center, and the positions of the infrared focusing heater and the infrared temperature sensor are not overlapped, so that the temperature measurement accuracy of the infrared temperature sensor can be ensured, and the measurement error caused by the influence of the infrared focusing heater on the temperature measurement process of the infrared temperature sensor is avoided.
Preferably, the angular separation of the infrared focusing heater and the infrared temperature sensor is greater than 10 °.
It should be noted that one or more infrared focusing heaters may be disposed above the centrifugal microfluidic chip 1, or one or more infrared temperature sensors may be disposed above the centrifugal microfluidic chip 1, but it is necessary to ensure that the positions of the infrared focusing heaters and the infrared temperature sensors do not overlap.
For example, if three infrared focusing heaters and one infrared temperature sensor are required, they may be arranged according to the structure shown in fig. 3, that is, three infrared focusing heaters and one infrared temperature sensor are respectively arranged on a circumference which takes the center of the centrifugal microfluidic chip 1 as the center and the distance between the reaction tank 6 and the center as the radius, so that the separation angle between the infrared focusing heaters and the infrared temperature sensors is 90 ° or 180 °. It can be set in other forms, but it is necessary to ensure that the infrared focusing heater is spaced from the infrared temperature sensor by an angle larger than 10 °.
Preferably, the temperature control device performs temperature control operation on the liquid through a temperature control algorithm, wherein the temperature control algorithm is a PID algorithm, a fuzzy PID algorithm or a neural network control algorithm. The temperature control algorithm is mainly used for changing the PWM duty ratio so as to effectively drive the infrared focusing heater to operate.
It should be noted that the infrared temperature sensor monitors the temperature of the reaction tank 6 in real time, and feeds the temperature situation back to the temperature control device in real time, the temperature control device can drive the infrared focusing heater by using a PWM signal (pulse signal), and the duty ratio of the heater driving signal is changed according to the current temperature value and the temperature setting value returned by the temperature sensor by using a temperature control algorithm, because the heating power of the infrared focusing heater is increased along with the increase of the duty ratio of the voltage signal, the accurate control of the temperature control device on the local temperature of the reaction tank 6 of the centrifugal microfluidic chip 1 can be finally realized.
In addition, the device adopts infrared focusing heating to directly heat the liquid in the reaction tank 6, and utilizes the motor 32 to drive the centrifugal microfluidic chip 1 to rotate, so that the reaction tanks 6 distributed along the circumferential direction of the centrifugal microfluidic chip 1 sequentially appear below the infrared focusing heater and the infrared temperature sensor. The infrared temperature sensor can monitor the temperature of the chip reaction tank 6 in real time and feed back a temperature signal to the temperature control device, and the temperature control device realizes the accurate control of the local temperature of the reaction tank 6 of the centrifugal micro-fluidic chip 1 through a temperature control algorithm. Moreover, the wavelength of the infrared focusing heater can be reasonably selected according to the material of the centrifugal micro-fluidic chip 1 and the type of the liquid to be heated, so that the energy utilization rate of the device is further improved, the loss is reduced, and the temperature control precision of the device is improved.
It should be noted that the directions and positional relationships indicated by "upper" and "lower" in the present application are based on the directions and positional relationships shown in the drawings, and are only for the convenience of simplifying the description and facilitating the understanding, but do not indicate or imply that the device or element referred to must have a specific direction, be constructed and operated in a specific direction, and thus, should not be construed as limiting the present invention.
In addition to the chip temperature control device, the invention also provides a chip temperature control system including the chip temperature control device disclosed in the above embodiment. The chip temperature control system comprises a temperature control device and a main control device, wherein the temperature control device is any one of the chip temperature control devices, the driving device 3 and the temperature control device are both connected with the main control device, namely the main control device can control the driving device 3 to operate according to the temperature control condition fed back by the temperature control device, so that the automatic temperature control operation of the centrifugal micro-fluidic chip 1 is realized. For the structure of other parts of the chip temperature control system, please refer to the prior art, which is not described herein again.
The embodiments in the present description are described in a progressive manner, each embodiment focuses on differences from other embodiments, and the same and similar parts among the embodiments are referred to each other. Any combination of all embodiments provided by the present invention is within the scope of the present invention, and will not be described herein.
The chip temperature control system and the chip temperature control device thereof provided by the invention are described in detail above. The principles and embodiments of the present invention are explained herein using specific examples, which are presented only to assist in understanding the method and its core concepts. It should be noted that, for those skilled in the art, it is possible to make various improvements and modifications to the present invention without departing from the principle of the present invention, and those improvements and modifications also fall within the scope of the claims of the present invention.
Claims (10)
1. A chip temperature control apparatus, comprising: the device comprises a centrifugal micro-fluidic chip (1), a heating device (2), a driving device (3) for driving a reaction tank of the centrifugal micro-fluidic chip (1) to be close to or far away from the heating device (2), a temperature measuring device (4) for detecting the temperature of liquid in the reaction tank and a temperature control device, wherein the heating device (2) can penetrate through a shell of the centrifugal micro-fluidic chip (1) to directly heat the liquid, and the heating device (2) and the temperature measuring device (4) are connected with the temperature control device.
2. The chip temperature control device according to claim 1, wherein the driving device (3) comprises a fixing device (31) for axially fixing the centrifugal micro-fluidic chip (1) and a motor (32) for driving the centrifugal micro-fluidic chip (1) to rotate, the centrifugal micro-fluidic chip (1) is sleeved on the outer periphery of an output shaft of the motor (32), and the heating device (2) and the temperature measuring device (4) are both arranged on the fixing device (31).
3. The chip temperature control device according to claim 2, wherein the heating device (2) is an infrared focusing heater.
4. The on-chip temperature control device of claim 3, wherein the operating light of the infrared focusing heater is in the wave number range of 3600cm-1-2800cm-1Or 1000cm-1-1800cm-1A single wavelength or a combination of a plurality of said wavelengths.
5. The chip temperature control device according to claim 3, wherein the temperature measuring device (4) is an infrared temperature sensor.
6. The chip temperature control device according to claim 5, wherein the fixing means (31) comprises a hollowed-out portion (5) for fixing the infrared focusing heater and the infrared temperature sensor.
7. The chip temperature control device according to claim 6, wherein the distance between the infrared focusing heater and the center of the centrifugal microfluidic chip (1) is equal to the distance between the infrared temperature sensor and the center, and the positions of the infrared focusing heater and the infrared temperature sensor do not overlap.
8. The chip temperature control device according to claim 7, wherein the angular separation of the infrared focusing heater and the infrared temperature sensor is greater than 10 °.
9. The chip temperature control device according to any one of claims 1 to 8, wherein the temperature control device performs temperature control operation on the liquid through a temperature control algorithm, and the temperature control algorithm is a PID algorithm, a fuzzy PID algorithm or a neural network control algorithm.
10. A chip temperature control system, comprising a temperature control device and a main control device, wherein the temperature control device is the chip temperature control device according to any one of claims 1 to 9, and the driving device (3) and the temperature control device are both connected with the main control device.
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| CN202110217605.6A CN112987816A (en) | 2021-02-26 | 2021-02-26 | Chip temperature control system and chip temperature control device thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116574603A (en) * | 2023-07-14 | 2023-08-11 | 潍坊安普未来生物科技有限公司 | Isothermal amplification detection device and detection method |
| CN117742410A (en) * | 2023-12-26 | 2024-03-22 | 首都医科大学附属北京儿童医院 | Temperature control system and micro-fluidic chip detection system |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20080019881A1 (en) * | 2004-09-30 | 2008-01-24 | Arkray, Inc. | Analyzer |
| CN101126715A (en) * | 2007-09-21 | 2008-02-20 | 博奥生物有限公司 | Micro-nano system fluid chip detection system and detection method |
| CN103820316A (en) * | 2014-03-09 | 2014-05-28 | 北京工业大学 | Real-time fluorescence PCR (polymerase chain reaction) detection system based on rotary type microfluidic chip |
| US20160214112A1 (en) * | 2013-09-11 | 2016-07-28 | Osaka University | Thermal convection generating chip, thermal convection generating device, and thermal convection generating method |
| CN107583698A (en) * | 2017-11-01 | 2018-01-16 | 清华大学 | Micro-fluidic chip and micro fluidic device |
| CN111266139A (en) * | 2020-03-02 | 2020-06-12 | 京东方科技集团股份有限公司 | Temperature control system, detection system and temperature control method of micro-fluidic chip |
| CN112138735A (en) * | 2020-09-12 | 2020-12-29 | 深圳市和来生物技术有限公司 | Heating, temperature detection and optical detection device and method for micro-fluidic chip |
-
2021
- 2021-02-26 CN CN202110217605.6A patent/CN112987816A/en active Pending
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20080019881A1 (en) * | 2004-09-30 | 2008-01-24 | Arkray, Inc. | Analyzer |
| CN101126715A (en) * | 2007-09-21 | 2008-02-20 | 博奥生物有限公司 | Micro-nano system fluid chip detection system and detection method |
| US20160214112A1 (en) * | 2013-09-11 | 2016-07-28 | Osaka University | Thermal convection generating chip, thermal convection generating device, and thermal convection generating method |
| CN103820316A (en) * | 2014-03-09 | 2014-05-28 | 北京工业大学 | Real-time fluorescence PCR (polymerase chain reaction) detection system based on rotary type microfluidic chip |
| CN107583698A (en) * | 2017-11-01 | 2018-01-16 | 清华大学 | Micro-fluidic chip and micro fluidic device |
| CN111266139A (en) * | 2020-03-02 | 2020-06-12 | 京东方科技集团股份有限公司 | Temperature control system, detection system and temperature control method of micro-fluidic chip |
| CN112138735A (en) * | 2020-09-12 | 2020-12-29 | 深圳市和来生物技术有限公司 | Heating, temperature detection and optical detection device and method for micro-fluidic chip |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116574603A (en) * | 2023-07-14 | 2023-08-11 | 潍坊安普未来生物科技有限公司 | Isothermal amplification detection device and detection method |
| CN116574603B (en) * | 2023-07-14 | 2023-09-19 | 潍坊安普未来生物科技有限公司 | Isothermal amplification detection device and detection method |
| CN117742410A (en) * | 2023-12-26 | 2024-03-22 | 首都医科大学附属北京儿童医院 | Temperature control system and micro-fluidic chip detection system |
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Application publication date: 20210618 |