CN112603987B

CN112603987B - Patch for treating male erectile dysfunction and preparation method thereof

Info

Publication number: CN112603987B
Application number: CN202110018542.1A
Authority: CN
Inventors: 李平; 王海洋; 王兴旺; 曾青钦
Original assignee: Hainan Spider King Biotechnology Co ltd
Current assignee: Hainan Spider King Biotechnology Co ltd
Priority date: 2021-01-07
Filing date: 2021-01-07
Publication date: 2022-12-02
Anticipated expiration: 2041-01-07
Also published as: CN112603987A; WO2022147925A1

Abstract

The invention relates to the technical field of traditional Chinese medicines, and particularly discloses a patch for treating male erectile dysfunction and a preparation method thereof. The active medicine of the patch consists of a Li medicine Aranea alcohol extract, water extracts of five medicines of rhizoma alismatis, tuckahoe, schisandra chinensis, fructus psoraleae and dried ginger, cinnamon and musk; on the basis of arranging and improving folk prescriptions related to the Li-medicine spider, the invention provides the navel patch containing the Li-medicine spider, which is used for treating male erectile dysfunction and improving male sperm activity and quality by applying the current research means and matching with other traditional Chinese medicinal materials such as tuckahoe, musk and the like according to the principle of assistant and guide synergistic promotion of traditional Chinese medicines, so that the body and mind severe burden caused by long-term oral administration of medicines, particularly western medicines, can be avoided while the male erectile function is effectively improved.

Description

Patch for treating male erectile dysfunction and preparation method thereof

Technical Field

The invention relates to the technical field of traditional Chinese medicines, in particular to a patch for treating male erectile dysfunction and a preparation method thereof.

Background

With the continuous acceleration of life rhythm, air pollution, bad living habits, heredity and other factors, the male organism in China is easy to be over-fatigued, so that the sexual dysfunction is increasingly serious, and the number of people is increased. The male sexual dysfunction is mainly manifested as impotence and premature ejaculation, and is accompanied by the phenomena of infertility, infertility and the like caused by little sperms, insufficient vitality and the like, and the life quality is seriously influenced. The traditional medicine for treating male dysfunction mainly takes western medicines as main medicines, has quick response but more side effects or adverse reactions, and causes greater burden on health after long-term administration.

Spider, li Yao, has effects of invigorating qi, replenishing blood, replenishing essence and tonifying yang, and can be used for treating weak Mingmen fire, kidney yang deficiency, sexual impotence, deficiency cold of lower origin, cold essence and semen atony. Local people in Li nationality of Hainan are usually treated by baking spiders or soaking spiders in wine to strengthen the body and resist damp evil. Although the habit of the spider, li Yao, is inherited over thousands of years, li nationality has no characters, inheritance depends mainly on oral-oral transmission, and classical proved recipes scatter folk systems, and there is no scientific systematic research basis and clinical trial basis.

Disclosure of Invention

In view of the above, an object of the present invention is to provide a patch for treating male erectile dysfunction and a method for preparing the same, which enables the patch to be used for a human body to close the navel and can significantly improve male erectile dysfunction.

In order to achieve the purpose of the invention, the invention provides the following technical scheme:

a patch for the treatment of male erectile disfunction comprises active medicinal materials including Aranea extract, water extracts of Alismatis rhizoma, poria, fructus Schisandrae chinensis, fructus Psoraleae, zingiberis rhizoma, cortex Cinnamomi and Moschus (artificial).

The Li medicine spider selected by the invention is a special national geographic sign agricultural product of Hainan Wuzhishan-spider. The five-finger mountain spiders are famous for being used as the folk heritage and folk inheritance experiential prescription of Li nationality, are crispy and delicious after being baked, have long aftertaste, and have long-standing humanistic history and edible and medicinal traditions for thousands of years. The edible oil fried spiders and the barbecue spiders of Hainan Li nationality have the history of thousands of years by soaking wine by the spiders, and have the effects of nourishing yin, tonifying yang and strengthening the body. The roasted spiders used by Li doctors have the effects of reducing pathogenic fire, dispelling cold, tonifying yang and tonifying kidney, and are used for treating deficiency, so that the social cognition degree is high. Modern research means finds that the spiders of the five-finger mountain are high in protein, rich in calcium, manganese, zinc, iron and other trace elements necessary for human bodies, and not only are nutritious and delicious, but also have remarkable health care and treatment effects.

Meanwhile, the traditional Chinese medicine is a local and genuine medicinal material, can eliminate dampness, diminish inflammation, detoxify and tonify kidney yang, can treat various diseases such as rheumatic osteodynia, oblique middle-jiao tuo and the like when used as a medicine, and is recorded in various counties, medical records and the like, wherein Shansheng is doubly big. People in Li nationality in Hainan have the effects of dispelling wind and removing dampness by eating roasted spiders or soaking spiders in wine and the like in the ancient way, and strengthening the body; spiders are also used as monarch drugs in the local Li doctor in Wuzhishan mountain for treating gout, rheumatism, joint swelling and pain, neck and waist soreness and other diseases, and the curative effect is highly approved by local patients; however, no relevant record is found about the application of the patch to the guanyuan under the navel.

The five-finger spider is matched with other traditional Chinese medicine components to jointly treat male erectile dysfunction:

alismatis rhizoma has effects of invigorating kidney and spleen, promoting diuresis, eliminating dampness, improving hearing and eyesight, prolonging life, and reducing weight, and can be used for treating Meniere's disease, dyslipidemia, spermatorrhea, fatty liver, diabetes, etc. The book Jing: it is effective in treating arthralgia due to wind-cold-dampness, quenching thirst, nourishing five internal organs, and invigorating qi. "Addite records": to tonify deficiency and impair five internal organs, remove fullness and fullness of five internal organs, activate yin qi, stop diarrhea, quench thirst, drain dribbling, expel bladder and triple energizer and stop water. "

Poria cocos, a dried sclerotium of Wolf of Poria cocos (Schw.) belonging to Polyporaceae, has mild drug properties, can tonify spleen, expel water, promote the production of body fluid, guide qi, and have the effects of treating both principal and secondary aspects of diseases such as diarrhea and leukorrhagia caused by spleen deficiency, transportation and transformation disorder, and is often used as an adjuvant drug for invigorating spleen and tonifying qi.

Fructus Schisandrae chinensis, a dried mature fruit of Schisandra chinensis (Turcz.) Baill. Of Magnoliaceae, has effects of astringing, invigorating qi, promoting fluid production, invigorating kidney, calming heart, and is commonly used for spermatorrhea, chronic diarrhea, spontaneous perspiration, night sweat, body fluid consumption, thirst, etc.

Fructus Psoraleae, entering kidney and spleen channels, invigorating kidney and strengthening yang, and arresting seminal emission and reducing urination, can be used for treating kidney essence deficiency and sexual impotence, soreness and weakness of waist and knees, nocturnal emission, enuresis, frequent micturition, cough and asthma due to deficiency cold.

Cinnamon, being suitable for guiding all herbs, warms middle energizer and tonifies kidney, strengthens bones and muscles, unblocks blood vessels, treats all diseases and nourishes spirit.

Musk, which enters heart and spleen meridians, induces resuscitation and refreshes mind, activates blood and clears meridians, relieves swelling and pain, and is indicated for sores and ulcers, pyogenic infections, scrofula, subcutaneous nodule, swollen and sore throat, traumatic injury, arthralgia due to wind-cold-dampness, etc.

Preferably, the raw material medicines comprise, by weight, 4-6 parts of liyama spider, 15-25 parts of rhizoma alismatis, 20-30 parts of poria cocos, 15-25 parts of schisandra chinensis, 25-35 parts of fructus psoraleae, 3-7 parts of cinnamon, 1-3 parts of rhizoma zingiberis and 0.5-1.5 parts of musk.

In the specific embodiment of the invention, the raw material medicines comprise 5 parts of kadsura root, 20 parts of rhizoma alismatis, 25 parts of poria cocos, 20 parts of schisandra chinensis, 30 parts of fructus psoraleae, 5 parts of cinnamon, 2 parts of dried ginger and 1 part of musk in parts by weight.

Preferably, the vera drug arachidic extract is an ethanol-soaked extract thereof. In a specific embodiment of the invention, the ethanol is 70-90% ethanol.

Meanwhile, the invention also provides a preparation method of the patch, which comprises the following steps:

step 1, soaking radix picrorhizae in ethanol to obtain an ethanol extract; extracting Alismatis rhizoma, poria, fructus Schisandrae chinensis, fructus Psoraleae, and Zingiberis rhizoma with water, and precipitating with ethanol to obtain water extractive solution; mixing the water extract and the alcohol extract, and concentrating to obtain alcohol-free fluid extract;

and 2, adding cinnamon and musk into the fluid extract, mixing into thick paste, and coating the thick paste on a patch substrate (such as cataplasm) to prepare the patch.

Preferably, the alcohol extract is obtained by the following preparation method:

soaking the spider lyophilized powder in 10-30 times of 70-90% ethanol at room temperature for 24-72 hr, and mixing extractive solutions to obtain ethanol extractive solution.

Preferably, the water extract is obtained by the following preparation method:

adding ten times of water into rhizoma Alismatis, poria, fructus Schisandrae chinensis, fructus Psoraleae, and rhizoma Zingiberis, boiling and extracting for 1-3 hr for one or more times, mixing the medicinal liquids, and concentrating; adding 70-90% ethanol, stirring, and precipitating with ethanol to obtain water extractive solution.

In order to verify the treatment effect of the patch on the Guanyuan under the umbilicus, the invention discovers that the clinical test effect of the patch is obviously inferior to that of a test group after deleting any medicinal material by deleting the spiders, the schisandra chinensis or the fructus psoraleae. Meanwhile, the spiders from the five-finger mountains in the prescription are replaced by common yang-tonifying medicinal materials such as epimedium herb or pilose antler, and probably because the medicinal materials of the epimedium herb and the pilose antler are more suitable for oral administration and nourishing bodies, the clinical effect of the prepared contrast patch is not obviously enhanced.

According to the technical scheme, on the basis of arranging and improving folk prescriptions related to the Li-medicine spider, the navel patch containing the Li-medicine spider is provided by applying the existing research means and matching with other traditional Chinese medicinal materials such as poria cocos and musk according to the principle of promoting the synergy of monarch, minister, assistant and guide of traditional Chinese medicines, and the like, so that the male erectile function is effectively improved, and the serious physical and mental burden caused by long-term oral administration of medicines, particularly western medicines, can be avoided.

Detailed Description

The invention discloses a patch for treating male erectile dysfunction and a preparation method thereof, and a person skilled in the art can realize the patch by properly improving process parameters by taking the contents into consideration. It is specifically noted that all such substitutions and modifications will be apparent to those skilled in the art and are intended to be included herein. While the patch of the present invention and the method of manufacturing the same have been described in terms of preferred embodiments, it will be apparent to those skilled in the art that the techniques of the present invention may be practiced and applied by modifying or appropriately combining the patch and the method of manufacturing the same described herein without departing from the spirit, scope and spirit of the invention.

The navel is the Shenque Yang acupoint on the human body's conception vessel, and is the most critical acupoint and longevity big acupoint of the human body. The acupoint is used as a portal network of spirit, so the health care wine has the functions of restoring yang and rescuing, dredging orifices and syncope, can regulate and protect Shenque acupoint, can regulate all pulses of qi and blood, is full of spirit, full of physical strength, strong in lumbar muscle, ruddy in complexion, hearing and eyesight, light in weight and prolonging life. It has unique curative effect on abdominal pain, borborborygmus, edema, diarrhea, rectocele, apoplexy, etc. and is healthy, young and not old. The patch provided by the invention is used for the Guanyuan under the umbilicus, and the drug effect of the patch acts on the conception vessel to realize

In the specific embodiment of the invention, the raw material medicines adopted by each treatment group of the provided comparative test are the same, and the test conditions of each group are consistent except for the difference.

The raw material drugs, reagents and the like related to the invention can be obtained by a commercial route unless otherwise specified.

The invention is further illustrated by the following examples.

Example 1: preparation of the Patch of the invention

1. Formulation(s)

5 parts (5 g) of freeze-dried powder of spiders of five-finger mountain, 20 parts (20 g) of rhizoma alismatis, 25 parts (25 g) of poria cocos, 20 parts (20 g) of schisandra chinensis, 30 parts (30 g) of fructus psoraleae, 5 parts (5 g) of cinnamon, 2 parts (2 g) of dried ginger and 1 part (1 g) of musk (artificial);

2. method for producing

(1) Soaking Aranea lyophilized powder in 20 times of 80% ethanol at room temperature for 48 hr, and mixing extractive solutions.

(2) Extracting other materials (except Moschus and cortex Cinnamomi) with water, adding ten times of water, boiling and extracting for two times (each for 1.5 hr), mixing the extractive solutions, and concentrating to relative density of 1.2; adding 70% ethanol, stirring, slowly adding, and stirring for 30 min. Cooling the jacket of the alcohol precipitation tank with cooling water, and standing for 48 hours; mixing the supernatant with Aranea extractive solution, and concentrating until there is no alcohol. Relative density 1.12, resulting in about 100ml of liquid.

(3) Pulverizing cortex Cinnamomi into superfine powder (powder which can pass through six-mesh sieve and not less than 95% of seven-mesh sieve as specified in Chinese pharmacopoeia (2015 edition)), adding Moschus into the fluid extract, and concocting into soft extract.

(4) Adding appropriate amount of matrix into the soft extract, and coating to obtain patch. It is applied to the lower part of navel (Guanyuan) once a day.

Example 2: experiment of therapeutic Effect

The preparation is prepared by a certain Chinese medicine institute in Hainan province, and clinical tests are carried out in a specialized consulting room of Li nations' medicine. 200 male clinical trial patients aged 40-60 years are selected, divided into 7 groups, and 30 patients in each group except for 20 control groups (without any treatment) are subjected to clinical trial for 90 days, according to the cure improvement standard of clinical disease diagnosis according to the cure improvement standard, the cure standard: the penis can erect and perform sexual intercourse. Improvement standard: the penis can erect transiently but the intercourse can not be completed. And (4) invalidation: the penis is unable to erect and unable to intercourse. The specific test results are shown in table 1.

TABLE 1

As can be seen from the table 1, the navel patch provided by the invention has the effective rate of 90% for treating male erectile dysfunction, has an obvious curative effect, and has no adverse reaction. By subtracting any one of spider, schisandra or fructus psoraleae, the clinical test effect (comparison group 1, comparison group 2 and comparison group 3) is obviously inferior to that of the test group after the medicinal material is deleted. Meanwhile, the five-finger mountain spider is replaced by common yang-strengthening medicinal materials such as epimedium herb, pilose antler and the like, probably because the epimedium herb and the pilose antler are more suitable for oral administration and nourishing bodies, the clinical effect (the comparison group 4 and the comparison group 5) of the patch prepared by the method is also obviously inferior to that of the test group.

The foregoing is only a preferred embodiment of the present invention, and it should be noted that, for those skilled in the art, various modifications and decorations can be made without departing from the principle of the present invention, and these modifications and decorations should also be regarded as the protection scope of the present invention.

Claims

1. A patch for treating male erectile dysfunction comprises the following formula:

5 parts of freeze-dried powder of spider, 20 parts of rhizoma alismatis, 25 parts of poria cocos, 20 parts of schisandra chinensis, 30 parts of fructus psoraleae, 5 parts of cinnamon, 2 parts of dried ginger and 1 part of musk;

the preparation method of the Wuzhishan spider freeze-dried powder comprises the following steps: soaking with 20 times of 80% ethanol at normal temperature for 48 hr, and mixing extractive solutions;

the preparation method of the patch for treating male erectile dysfunction comprises the following steps:

adding ten times of water into the other medicinal materials except Moschus and cortex Cinnamomi, boiling and extracting for two times, each for 1.5 hr, mixing medicinal liquids, and concentrating to relative density of 1.2; adding 70% ethanol, stirring, slowly adding, and stirring for 30 min; cooling the jacket of the alcohol precipitation tank with cooling water, and standing for 48 hours; mixing the supernatant with Aranea extractive solution, and concentrating until there is no alcohol; the relative density is 1.12, and 100ml of liquid is obtained;

pulverizing cortex Cinnamomi into superfine powder, adding Moschus into the fluid extract, and concocting into soft extract;

adding appropriate amount of matrix into the soft extract, and coating to obtain patch.