CN112603906A - Microcapsule framework material and preparation method thereof - Google Patents

Abstract

The invention discloses a microcapsule framework material and a preparation method thereof, wherein the microcapsule framework material comprises the following components in percentage by weight: 10-15 parts of ethyl cellulose, 15-30 parts of ethylene-vinyl acetate copolymer, 8-10 parts of hydrogenated vegetable oil, 6-10 parts of carnauba wax, 20-30 parts of hydroxypropyl methyl cellulose, 30-60 parts of sodium alginate and 15-25 parts of chitin. The matrix material prepared by the invention has the performance that the in vitro release degree accords with the zero-order drug release process, the active ingredients of the drug can effectively avoid the photodecomposition under the protection of the protective layer and the coating layer, the content and the release degree of the drug in an accelerated experiment have no obvious change, the stability is very high, and great convenience is brought to the treatment work.

Description

Microcapsule framework material and preparation method thereof

Technical Field

The invention relates to the technical field of microcapsules, in particular to a microcapsule framework material.

Background

The microcapsule is a microcapsule with a polymer wall shell and a micro container or a package, the microcapsule granulation technology is a technology for embedding and sealing solid, liquid or gas in a micro capsule to form a solid particle product, a framework material is required in the preparation of the microcapsule, but the existing framework material has no good stability, can be quickly melted when meeting water, reduces the drug effect of the microcapsule and brings great inconvenience to treatment work.

Disclosure of Invention

The invention aims to provide a microcapsule framework material which has the advantage of good use performance and solves the problems that the existing framework material does not have good stability, can be quickly melted when meeting water, reduces the drug effect of the microcapsule and brings great inconvenience to treatment work.

In order to achieve the purpose, the invention provides the following technical scheme: a microcapsule framework material comprises the following components in percentage by weight:

10-15 parts of ethyl cellulose; 15-30 parts of ethylene-vinyl acetate copolymer;

8-10 parts of hydrogenated vegetable oil; 6-10 parts of carnauba wax;

20-30 parts of hydroxypropyl methyl cellulose; 30-60 parts of sodium alginate;

15-25 parts of chitin.

Preferably, the ethyl cellulose and the ethylene-vinyl acetate copolymer are insoluble materials.

Preferably, the hydrogenated vegetable oil and carnauba wax are biodegradable materials.

Preferably, the hydroxypropyl methyl cellulose, the sodium alginate and the chitin are hydrophilic framework materials.

Preferably, the ethyl cellulose, the ethylene-vinyl acetate copolymer, the hydrogenated vegetable oil and the carnauba wax are mixed together to prepare the hydrophobic framework material.

Preferably, the viscosity of the hydrophilic matrix material is in the range of 100 to 100000 mpa.s.

A preparation method of a microcapsule framework material comprises the following steps:

s1, mixing and stirring ethyl cellulose and ethylene-vinyl acetate copolymer to prepare a mixture A for later use;

s2, mixing and stirring the hydrogenated vegetable oil and the carnauba wax to prepare a mixture B for later use;

s3, mixing and stirring hydroxypropyl methylcellulose, sodium alginate and chitin to obtain a mixture C for later use;

s4, putting the mixture A, B, C into a reaction kettle, adding an organic solvent, magnetically stirring while performing ultrasonic treatment for 20-40min to obtain a mixture D, and taking out the mixture D for later use;

s5, then decompressing and evaporating the mixture D at the temperature of 30-50 ℃, collecting the solid, and crushing to obtain the microcapsule framework material.

Compared with the prior art, the invention has the following beneficial effects:

the matrix material prepared by the invention has the performance that the in vitro release degree accords with the zero-order drug release process, the active ingredients of the drug can effectively avoid the photodecomposition under the protection of the protective layer and the coating layer, the content and the release degree of the drug in an accelerated experiment have no obvious change, the stability is very high, and great convenience is brought to the treatment work.

Detailed Description

The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

The invention provides a technical scheme that:

a microcapsule framework material comprises the following components in percentage by weight:

10-15 parts of ethyl cellulose; 15-30 parts of ethylene-vinyl acetate copolymer;

8-10 parts of hydrogenated vegetable oil; 6-10 parts of carnauba wax;

20-30 parts of hydroxypropyl methyl cellulose; 30-60 parts of sodium alginate;

15-25 parts of chitin.

The first embodiment is as follows:

firstly, mixing and stirring ethyl cellulose and ethylene-vinyl acetate copolymer to prepare a mixture A for later use, then mixing and stirring hydrogenated vegetable oil and carnauba wax to prepare a mixture B for later use, and then mixing and stirring hydroxypropyl methyl cellulose, sodium alginate and chitin to prepare a mixture C for later use; then putting the mixture A, B, C into a reaction kettle, adding an organic solvent, magnetically stirring and ultrasonically treating for 20-40min to obtain a mixture D, and taking out for later use; and finally, evaporating the mixture D under reduced pressure at the temperature of 30-50 ℃, collecting solids, and crushing to obtain the microcapsule framework material.

Example one experimental group comprised of:

	1	2	3	4	5	6
							ethyl cellulose	12	15	10	11	14	13
Ethylene-vinyl acetate copolymer	25	30	28	20	22	26
							Hydrogenated vegetable oil	10	8	9	6	9	7
Carnauba wax	8	10	6	7	8	9
							Hydroxypropyl methylcellulose	25	20	30	24	28	22
Sodium alginate	30	55	45	40	35	60
							Chitin	20	25	10	15	18	22

Example II,

	1	2	3	4	5	6
							Ethyl cellulose	13	16	11	13	14	13
Ethylene-vinyl acetate copolymer	25	30	28	20	22	26
							Mixing hydrogenated vegetable oil and Cera flava 1:1 Combination of Chinese herbs	8	10	9	8	9	6
Carnauba wax	8	10	6	7	8	9
							Hydroxypropyl methylcellulose	25	20	30	24	28	22
Polyvinyl alcohol	40	50	55	45	35	60
							Glucan	30	20	25	10	15	22

Example III,

	1	2	3	4	5	6
							Ethyl cellulose	12	15	10	11	14	13
Ethylene-vinyl acetate copolymer	25	30	28	20	22	26
							C16-C22Fatty acid glycerides	8	10	15	8	9	6
Carnauba wax	10	8	7	9	6	9
							Hydroxyethyl methyl cellulose	25	20	30	24	28	22
Galactomannan	55	40	50	45	35	60
							Carboxylic acid polymers	25	20	18	15	10	22

Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.

Claims (7)

1. A microcapsule matrix material, characterized in that: the components by weight percentage are as follows:

10-15 parts of ethyl cellulose; 15-30 parts of ethylene-vinyl acetate copolymer;

8-10 parts of hydrogenated vegetable oil; 6-10 parts of carnauba wax;

20-30 parts of hydroxypropyl methyl cellulose; 30-60 parts of sodium alginate;

15-25 parts of chitin.

2. A microcapsule matrix material according to claim 1, wherein: the ethyl cellulose and the ethylene-vinyl acetate copolymer are insoluble materials.

3. A microcapsule matrix material according to claim 1, wherein: the hydrogenated vegetable oil and carnauba wax are biodegradable materials.

4. A microcapsule matrix material according to claim 1, wherein: the hydroxypropyl methylcellulose, the sodium alginate and the chitin are hydrophilic framework materials.

5. A microcapsule matrix material according to claim 1, wherein: the ethyl cellulose, the ethylene-vinyl acetate copolymer, the hydrogenated vegetable oil and the carnauba wax are mixed together to prepare the hydrophobic framework material.

6. A microcapsule matrix material according to claim 4, wherein: the viscosity of the hydrophilic matrix material ranges from 100 to 100000 mpa.s.

7. A method for preparing a microcapsule framework material is characterized by comprising the following steps: the method comprises the following steps:

s1, mixing and stirring ethyl cellulose and ethylene-vinyl acetate copolymer to prepare a mixture A for later use;

s2, mixing and stirring the hydrogenated vegetable oil and the carnauba wax to prepare a mixture B for later use;

s3, mixing and stirring hydroxypropyl methylcellulose, sodium alginate and chitin to obtain a mixture C for later use;

s4, putting the mixture A, B, C into a reaction kettle, adding an organic solvent, magnetically stirring while performing ultrasonic treatment for 20-40min to obtain a mixture D, and taking out the mixture D for later use;

s5, evaporating the mixture D under reduced pressure at 30-50 ℃, collecting solids, and crushing to obtain the microcapsule framework material.