CN112536073A - Reagent bottle capable of controlling dropping liquid quality - Google Patents
Reagent bottle capable of controlling dropping liquid quality Download PDFInfo
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- CN112536073A CN112536073A CN202011226747.0A CN202011226747A CN112536073A CN 112536073 A CN112536073 A CN 112536073A CN 202011226747 A CN202011226747 A CN 202011226747A CN 112536073 A CN112536073 A CN 112536073A
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- reagent bottle
- reagent
- bottle body
- mouth
- bottle
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- 239000003153 chemical reaction reagent Substances 0.000 title claims abstract description 138
- 239000007788 liquid Substances 0.000 title claims abstract description 24
- 238000009434 installation Methods 0.000 claims description 12
- 239000000463 material Substances 0.000 claims description 2
- 238000004140 cleaning Methods 0.000 abstract description 4
- 238000011532 immunohistochemical staining Methods 0.000 abstract description 3
- 230000002572 peristaltic effect Effects 0.000 description 4
- 238000000034 method Methods 0.000 description 2
- 238000005406 washing Methods 0.000 description 2
- 230000004075 alteration Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 230000002055 immunohistochemical effect Effects 0.000 description 1
- 238000003364 immunohistochemistry Methods 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000010827 pathological analysis Methods 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 238000007447 staining method Methods 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/52—Containers specially adapted for storing or dispensing a reagent
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/30—Staining; Impregnating ; Fixation; Dehydration; Multistep processes for preparing samples of tissue, cell or nucleic acid material and the like for analysis
- G01N1/31—Apparatus therefor
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Physics & Mathematics (AREA)
- Physics & Mathematics (AREA)
- Biomedical Technology (AREA)
- Analytical Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Medicinal Chemistry (AREA)
- Clinical Laboratory Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
Abstract
The invention relates to the technical field of immunohistochemical staining, in particular to a reagent bottle with controllable dropping liquid quality, which comprises a reagent bottle body, wherein the reagent bottle body comprises a reagent bottle lower bottle body and a reagent bottle upper bottle body, the reagent bottle lower bottle body is arranged on the lower side of the reagent bottle body, a reagent bottle mouth is arranged on the upper side of the reagent bottle lower bottle body, a connecting external thread is arranged on the outer wall of the reagent bottle mouth, a bottle mouth mounting end is arranged on the upper side of the reagent bottle mouth, the reagent bottle upper bottle body is arranged on the upper side of the reagent bottle body, the reagent bottle upper bottle body comprises a needle head connecting seat and a needle head body, the needle head connecting seat is arranged on the lower side of the reagent bottle upper bottle body of the reagent bottle and in a position corresponding to the bottle mouth mounting end, a limiting mounting plug is arranged at the bottom of the needle head connecting seat, and the device, the cleaning and switching operation during the switching of different liquids are completely eliminated, and the operation time is greatly shortened.
Description
Technical Field
The invention relates to the technical field of immunohistochemical staining, in particular to a reagent bottle capable of controlling dropping liquid quality.
Background
Immunohistochemical staining technology is an important staining method in pathological technology, plays a very important auxiliary role in pathological diagnosis, and pathologists need to determine the nature, type, extent of involvement and the like of lesions by immunohistochemistry in many cases.
In the immunohistochemical process flow, a large amount of reagents can be used, such as DAB color developing solution, primary antibody and secondary antibody, most of the reagents adopt a reagent bottle dropwise adding mode, some antibodies are expensive (about 1ml/3000 yuan), the amount of the dropwise added antibodies is different under different requirements, the dropwise adding amount does not meet the requirement, the dropwise adding amount is more than the required amount, the waste is caused, reagent adding is carried out in a laboratory, a special valve body and a special pipeline matched with a plunger pump or a micro peristaltic pump are generally used, the structure is complex, the operation is complex (the pipeline and the valve body are required to be cleaned when different liquids are operated, and the pipeline and the valve are required to be switched), the operation time is long (the cleaning and switching time) and the cost is high, the quantitative reagent bottle mode can be used, the complexity and the cost can be greatly reduced, the cleaning and switching operation when different liquids are switched can be completely.
The quality of the liquid drops dripped by the same existing reagent bottle every time is approximately consistent, the reagent bottles with a plurality of specifications are needed for obtaining the liquid drops with different qualities, the mold opening cost of the reagent bottles is expensive (thousands to tens of thousands), the overall cost is increased if different reagent bottles are selected, so that a plurality of inconveniences exist in the actual operation, and the problem is improved by the reagent bottle with controllable liquid drop quality.
Disclosure of Invention
The invention aims to provide a reagent bottle capable of controlling dropping liquid quality, so as to solve the problems in the background technology.
In order to achieve the purpose, the invention provides the following technical scheme:
the utility model provides a reagent bottle of controllable dropping liquid quality, includes the reagent bottle body, the reagent bottle body includes under the reagent bottle body and the reagent bottle on the bottle, the downside of reagent bottle body is provided with under the reagent bottle body, the upside of bottle is provided with the reagent bottle bottleneck under the reagent bottle, the external screw thread has been seted up to the outer wall of reagent bottle bottleneck, the upside of reagent bottle bottleneck is provided with the bottleneck installation end, the upside of reagent bottle body is installed on the reagent bottle body the bottle, the reagent bottle on the bottle body include syringe needle connecting seat and syringe needle body, the downside of bottle is provided with the syringe needle connecting seat and the position that corresponds with the bottleneck installation end on the reagent bottle, spacing installation stopper is installed to the bottom of syringe needle connecting seat, the upside of syringe needle connecting seat is provided with the syringe needle mount pad, the syringe needle body is installed to the upside of syringe.
Preferably, the inner diameter of the mouth of the reagent bottle is matched with the outer diameter of the limiting mounting plug, and the lower bottle body of the reagent bottle is detachably connected with the upper bottle body of the reagent bottle.
Preferably, the outer wall of the limiting installation plug is sleeved with an anti-skidding limiting sleeve, and the anti-skidding limiting sleeve is made of medical rubber materials.
Preferably, a liquid outlet through hole is formed in the middle of the limiting installation plug, and the limiting installation plug is communicated with the needle head body through the liquid outlet through hole.
Preferably, the specification and capacity of the lower body of the reagent bottle can be adjusted according to actual conditions.
Preferably, the shape and diameter of the needle body can be adjusted according to actual conditions, and the specification diameter of the needle body comprises 1.6mm, 1.2mm, 1mm, 0.9mm, 0.8mm, 0.7mm, 0.6mm, 0.5mm and 0.4 mm.
Compared with the prior art, the invention has the beneficial effects that:
1. according to the invention, the upper reagent bottle body is of a replaceable structure in a detachable connection mode through the matching use of the lower reagent bottle body and the upper reagent bottle body, so that the specification of the needle head body can be replaced according to actual conditions, in addition, the cost required by opening the mold of the reagent bottle can be saved due to the detachable structure of the upper reagent bottle body and the lower reagent bottle body, the overall cost can be reduced to a certain extent, the complexity and the cost can be greatly reduced by the device on the whole, the cleaning and switching operation during the switching of different liquids can be completely eliminated, and the operation time can be greatly shortened.
2. According to the invention, compared with the traditional mode of adding the reagent by using a plunger pump or a micro peristaltic pump and other structures, the overall structure of the reagent bottle body in the scheme is simple, the actual quantity control can be accurately carried out, the overall operation is convenient, and the reagent bottle is more practical.
Drawings
FIG. 1 is an overall perspective view of the present invention;
FIG. 2 is an overall front view of the present invention;
FIG. 3 is an overall top view of the present invention;
FIG. 4 is a schematic diagram of the structure of the upper bottle body of the reagent bottle of the present invention.
In the figure: 1-a reagent bottle body, 2-a reagent bottle lower body, 3-a reagent bottle upper body, 4-a reagent bottle mouth, 5-a connecting external thread, 6-a mouth mounting end, 7-a needle head connecting seat, 8-a needle head body, 9-a limiting mounting plug and 10-a needle head mounting seat.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all embodiments, and all other embodiments obtained by a person of ordinary skill in the art without creative efforts based on the embodiments of the present invention belong to the protection scope of the present invention.
Referring to fig. 1-4, the present invention provides a technical solution:
the utility model provides a reagent bottle of controllable dropping liquid quality, including reagent bottle body 1, reagent bottle body 1 includes under the reagent bottle 2 and on the reagent bottle body 3, the downside of reagent bottle body 1 is provided with under the reagent bottle 2, the upside of under the reagent bottle 2 is provided with reagent bottle bottleneck 4, connecting external screw thread 5 has been seted up to the outer wall of reagent bottle bottleneck 4, the upside of reagent bottle bottleneck 4 is provided with bottleneck installation end 6, on the reagent bottle body 1 the upside is installed on the reagent bottle body 3, on the reagent bottle body 3 includes syringe needle connecting seat 7 and syringe needle body 8, on the reagent bottle 3 the downside and be provided with syringe needle connecting seat 7 with the position that bottleneck installation end 6 corresponds, spacing installation stopper 9 is installed to the bottom of syringe needle connecting seat 7, the upside of syringe needle connecting seat 7 is provided with syringe needle mount pad 10, syringe needle body 8 is installed to the upside of syringe needle mount pad 10.
Example (b): specifically, referring to fig. 1-4, the inner diameter of the reagent bottle mouth 4 is adapted to the outer diameter of the limiting mounting plug 9, the lower reagent bottle body 2 is detachably connected to the upper reagent bottle body 3, the outer wall of the limiting mounting plug 9 is sleeved with an anti-slip limiting sleeve, the anti-slip limiting sleeve is made of medical rubber, a liquid outlet through hole is formed in the middle of the limiting mounting plug 9, the limiting mounting plug 9 is communicated with the needle body 8 through the liquid outlet through hole, the specification capacity of the lower reagent bottle body 2 can be adjusted according to actual conditions, the shape and the diameter of the needle body 8 can be adjusted according to actual conditions, and the specification diameter of the needle body 8 includes 1.6mm, 1.2mm, 1mm, 0.9mm, 0.8mm, 0.7mm, 0.6mm, 0.5mm and 0.4mm, the lower reagent bottle body 2 is matched with the upper reagent bottle body 3, so that the upper reagent bottle body 3 is detachably connected to the lower reagent bottle body 2, and the upper reagent bottle body 3 is capable of being detachably connected to each other The structure of trading, and then make 8 specifications of syringe needle body change according to actual conditions, bottle 3 and reagent bottle lower bottle 2 can save the required expense of reagent bottle die sinking for the detachable structure on the reagent bottle in addition, and then can reduce holistic cost to a certain extent, this device can reduce by a wide margin realization complexity and cost wholly, washing and switching operation when eliminating different liquid switch completely, shorten operating time greatly, 1 overall structure's of reagent bottle body setting is compared with the traditional mode that uses plunger pump or miniature peristaltic pump isotructure to add to the reagent in this scheme, this scheme overall structure is simple, and can carry out accurate accuse volume to the reality, and overall operation is convenient, more have the practicality.
The working process of the invention is as follows: when the reagent bottle is used, the reagent bottle body 1 is placed at a proper position, an experimenter selects the reagent bottle upper bottle body 3 with the needle head body 8 with the required specification and size, the reagent bottle upper bottle body 3 is installed on the reagent bottle lower bottle body 2, the experimenter holds the reagent bottle body 1 and inverts the reagent bottle body 1, the needle head body 8 is aligned to the position where the antibody needs to be added, the reagent bottle lower bottle body 2 is squeezed by hands, the antibody in the reagent bottle lower bottle body 2 can be dripped out through the needle head body 8, after the dripping is finished, the experimenter rotates the reagent bottle body 1 180 degrees and returns the reagent bottle body 1, or a mechanical clamping jaw is used for clamping the reagent bottle body 1, the dripping liquid and the returning operation are carried out, the reagent bottle lower replaceable body 2 is matched with the reagent bottle upper bottle body 3, so that the reagent bottle upper bottle body 3 is detachably connected with the reagent bottle lower bottle body 2, and the reagent bottle upper bottle body 3 is of a replaceable structure, and then make 8 specifications of syringe needle body change according to actual conditions, in addition reagent bottle go up bottle 3 and reagent bottle lower bottle 2 for the detachable structure can save the required expense of reagent bottle die sinking, and then can reduce holistic cost to a certain extent, this device can reduce realization complexity and cost by a wide margin wholly, washing and switching operation when eliminating different liquid switch completely, shorten operating time greatly, 1 overall structure's of reagent bottle body setting in this scheme is compared with the traditional mode that uses plunger pump or miniature peristaltic pump isotructure to add to the reagent, this scheme overall structure is simple, and can actually carry out accurate accuse volume, and overall operation is convenient, more have the practicality.
Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.
Claims (6)
1. The utility model provides a reagent bottle of controllable dropping liquid quality, includes reagent bottle body (1), its characterized in that: the reagent bottle comprises a reagent bottle lower body (2) and a reagent bottle upper body (3), wherein the reagent bottle lower body (2) is arranged on the lower side of the reagent bottle body (1), a reagent bottle mouth (4) is arranged on the upper side of the reagent bottle lower body (2), a connecting external thread (5) is arranged on the outer wall of the reagent bottle mouth (4), a mouth mounting end (6) is arranged on the upper side of the reagent bottle mouth (4), the reagent bottle upper body (3) is arranged on the upper side of the reagent bottle body (1), the reagent bottle upper body (3) comprises a needle head connecting seat (7) and a needle head body (8), the needle head connecting seat (7) is arranged on the lower side of the reagent bottle upper body (3) and in a position corresponding to the mouth mounting end (6), and a limiting mounting plug (9) is arranged at the bottom of the needle head connecting seat (7), the upper side of syringe needle connecting seat (7) is provided with syringe needle mount pad (10), syringe needle body (8) are installed to the upside of syringe needle mount pad (10).
2. A controlled drip quality reagent bottle according to claim 1, wherein: the inner diameter of the reagent bottle mouth (4) is matched with the outer diameter of the limiting mounting plug (9), and the lower reagent bottle body (2) is detachably connected with the upper reagent bottle body (3).
3. A controlled drip quality reagent bottle according to claim 1, wherein: the outer wall of the limiting installation plug (9) is sleeved with an anti-skidding limiting sleeve, and the anti-skidding limiting sleeve is made of medical rubber materials.
4. A controlled drip quality reagent bottle according to claim 1, wherein: a liquid outlet through hole is formed in the middle of the limiting installation plug (9), and the limiting installation plug (9) is communicated with the needle head body (8) through the liquid outlet through hole.
5. A controlled drip quality reagent bottle according to claim 1, wherein: the specification and capacity of the lower body (2) of the reagent bottle can be adjusted according to actual conditions.
6. A controlled drip quality reagent bottle according to claim 1, wherein: the shape and the diameter of syringe needle body (8) can be adjusted according to actual conditions, and the specification diameter of syringe needle body (8) includes 1.6mm, 1.2mm, 1mm, 0.9mm, 0.8mm, 0.7mm, 0.6mm, 0.5mm, 0.4 mm.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202011226747.0A CN112536073A (en) | 2020-11-06 | 2020-11-06 | Reagent bottle capable of controlling dropping liquid quality |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202011226747.0A CN112536073A (en) | 2020-11-06 | 2020-11-06 | Reagent bottle capable of controlling dropping liquid quality |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN112536073A true CN112536073A (en) | 2021-03-23 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202011226747.0A Pending CN112536073A (en) | 2020-11-06 | 2020-11-06 | Reagent bottle capable of controlling dropping liquid quality |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN112536073A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115487881A (en) * | 2022-09-19 | 2022-12-20 | 英诺维尔智能科技（苏州）有限公司 | Micro-fluidic protein purification chip |
Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN200998667Y (en) * | 2006-11-30 | 2008-01-02 | 王军 | Droplet nozzle type reagent bottle |
| EP2090515A1 (en) * | 2008-02-18 | 2009-08-19 | Seriplast | Divisible bottle designed to contain a liquid |
| US20140224382A1 (en) * | 2011-10-28 | 2014-08-14 | Thermo Fisher Scientific Oy | Reagent bottle cap, system, method and apparatus for handling closure caps and like |
| CN204352888U (en) * | 2014-12-23 | 2015-05-27 | 萨恩化学技术（上海）有限公司 | A kind of reagent bottle |
| CN204916560U (en) * | 2015-07-27 | 2015-12-30 | 何粉荣 | Take squeeze bottle of aciculiform drip nozzle |
| US20170144178A1 (en) * | 2014-07-31 | 2017-05-25 | Shenzhen Bona Medicinal Packaging Material Co., Ltd. | Spray Bottle and Spray Bottle Cap thereof |
| CN209749824U (en) * | 2019-03-29 | 2019-12-10 | 浙江三通塑业有限公司 | Stifled electron tobacco tar bottle is prevented to sharp mouth plastics pin type |
| CN210455790U (en) * | 2019-07-02 | 2020-05-05 | 天津贝罗尼生物科技有限公司 | Anti-overflow drips bottle |
| CN210708671U (en) * | 2019-10-09 | 2020-06-09 | 台州费斯电子有限公司 | Bottle cap for mounting needle |
-
2020
- 2020-11-06 CN CN202011226747.0A patent/CN112536073A/en active Pending
Patent Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN200998667Y (en) * | 2006-11-30 | 2008-01-02 | 王军 | Droplet nozzle type reagent bottle |
| EP2090515A1 (en) * | 2008-02-18 | 2009-08-19 | Seriplast | Divisible bottle designed to contain a liquid |
| US20140224382A1 (en) * | 2011-10-28 | 2014-08-14 | Thermo Fisher Scientific Oy | Reagent bottle cap, system, method and apparatus for handling closure caps and like |
| US20170144178A1 (en) * | 2014-07-31 | 2017-05-25 | Shenzhen Bona Medicinal Packaging Material Co., Ltd. | Spray Bottle and Spray Bottle Cap thereof |
| CN204352888U (en) * | 2014-12-23 | 2015-05-27 | 萨恩化学技术（上海）有限公司 | A kind of reagent bottle |
| CN204916560U (en) * | 2015-07-27 | 2015-12-30 | 何粉荣 | Take squeeze bottle of aciculiform drip nozzle |
| CN209749824U (en) * | 2019-03-29 | 2019-12-10 | 浙江三通塑业有限公司 | Stifled electron tobacco tar bottle is prevented to sharp mouth plastics pin type |
| CN210455790U (en) * | 2019-07-02 | 2020-05-05 | 天津贝罗尼生物科技有限公司 | Anti-overflow drips bottle |
| CN210708671U (en) * | 2019-10-09 | 2020-06-09 | 台州费斯电子有限公司 | Bottle cap for mounting needle |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115487881A (en) * | 2022-09-19 | 2022-12-20 | 英诺维尔智能科技（苏州）有限公司 | Micro-fluidic protein purification chip |
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| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
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Application publication date: 20210323 |