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CN111712491A - 四氢异喹啉类化合物、其制备方法、包含此类化合物的药物组合物及其用途 - Google Patents

四氢异喹啉类化合物、其制备方法、包含此类化合物的药物组合物及其用途 Download PDF

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CN111712491A
CN111712491A CN201980012210.3A CN201980012210A CN111712491A CN 111712491 A CN111712491 A CN 111712491A CN 201980012210 A CN201980012210 A CN 201980012210A CN 111712491 A CN111712491 A CN 111712491A
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CN111712491B (zh
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许叶春
柳红
唐炜
张向磊
顾詹妮
李恒
韩旭
朱峰华
冯春兰
董光玉
陈甜甜
陈五妍
蒋华良
陈凯先
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Shanghai Institute of Materia Medica of CAS
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Abstract

本发明公开了一种新型四氢异喹啉类化合物及其中间体的制备方法、药物组合物和用途。本发明的四氢异喹啉类化合物对磷酸二酯酶(PDE4)具有良好的抑制效果，可以用于预防、治疗或辅助治疗与磷酸二酯酶活性或表达相关的多种疾病，尤其是与PDE4相关的免疫和炎症性疾病如银屑病和关节炎等。

Description

PCT国内申请，说明书已公开。

Claims (10)

  1. PCT国内申请，权利要求书已公开。
CN201980012210.3A 2018-02-06 2019-02-03 四氢异喹啉类化合物、其制备方法、包含此类化合物的药物组合物及其用途 Active CN111712491B (zh)

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CN2018101180387 2018-02-06
CN201810118038.7A CN110117271A (zh) 2018-02-06 2018-02-06 四氢异喹啉类化合物、其制备方法、包含此类化合物的药物组合物及其用途
PCT/CN2019/074704 WO2019154395A1 (zh) 2018-02-06 2019-02-03 四氢异喹啉类化合物、其制备方法、包含此类化合物的药物组合物及其用途

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US12024521B2 (en) * 2020-06-30 2024-07-02 Prosetta Biosciences, Inc. Isoquinoline derivatives, methods of synthesis and uses thereof
CN117126134A (zh) * 2022-05-20 2023-11-28 中国科学院上海药物研究所 新型四氢异喹啉类化合物、其制备方法、包含此类化合物的药物组合物及其用途
CN114957221B (zh) * 2022-05-30 2023-05-12 广西师范大学 一种喹喔啉衍生物及其制备方法和应用
CN115260094B (zh) * 2022-06-16 2024-04-05 珠海润都制药股份有限公司 一种新的盐酸去甲乌药碱的合成方法
CN117510512A (zh) * 2022-07-29 2024-02-06 中国科学院上海药物研究所 一类多取代的四氢异喹啉化合物及制备方法、药物组合物和用途

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US4292320A (en) * 1973-07-30 1981-09-29 Fujisawa Pharmaceutical Company, Limited 1,2,3,4-Tetrahydroisoquinoline derivatives and the preparation thereof
WO2001064647A1 (en) * 2000-02-28 2001-09-07 Sanofi-Synthelabo Isoquinoline derivatives as pde4 inhibitors
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