CN111686626B

CN111686626B - Magnetic stirring device for pharmaceutical analysis

Info

Publication number: CN111686626B
Application number: CN202010566509.8A
Authority: CN
Inventors: 魏婧; 秦晶晶; 钱慧琴; 娄晓月; 李丽; 侯婷婷; 苗薇薇
Original assignee: Sanquan College of Xinxiang Medical University
Current assignee: Sanquan College of Xinxiang Medical University
Priority date: 2020-06-19
Filing date: 2020-06-19
Publication date: 2022-03-08
Anticipated expiration: 2040-06-19
Also published as: CN111686626A

Abstract

The invention discloses a magnetic stirring device for drug analysis, which comprises a magnetic stirrer, wherein a stirring shell is placed in a beaker, the top of the stirring shell is connected with a stirring barrel, liquid leakage holes are formed in the outer sides of the stirring shell and the stirring barrel, a multipoint stirring piece for stirring a drug solution in the beaker at multiple positions is arranged in the stirring shell, the top of the beaker is connected with a clamping piece for clamping the beaker, the clamping piece is connected with the top of a water bath kettle, and the top of the stirring barrel is connected with a lifting piece for lifting the stirring barrel. The shaking of the beaker caused by heating in the water bath is reduced.

Description

Magnetic stirring device for pharmaceutical analysis

Technical Field

The invention relates to the technical field of stirring devices, in particular to a magnetic stirring device for drug analysis.

Background

The magnetic stirrer is a laboratory instrument for mixing liquid, and is mainly used for stirring or simultaneously heating and stirring liquid with low viscosity or a solid-liquid mixture, the basic principle is that the principle that like poles repel and opposite poles attract of a magnetic field is utilized, the magnetic field is used for pushing a magnetic stirrer placed in a container to perform circumferential operation, so that the purpose of stirring the liquid is achieved, and the magnetic stirrer is matched with a heating temperature control system, can heat and control the temperature of a sample according to specific experimental requirements, maintains the temperature condition required by the experimental conditions, ensures that the liquid is mixed to meet the experimental requirements, and is convenient for fully stirring the medicinal solution by adopting a magnetic stirring mode during medicinal analysis.

There is a heating type magnetic stirrer in the existing market, which heats a beaker with stirring by means of water bath heating, and simultaneously, under the magnetic force action of the magnetic stirrer, a stirrer placed inside the stirring beaker stirs the solution inside the beaker, but when the existing magnetic stirrer stirs, the stirrer placed inside the beaker rotates by adsorption under the action of a magnetic field formed at the bottom of the stirrer, a stirring water column is formed inside the beaker, the stirring water column formed by the stirrer is located at the center of the beaker, the stirring water column drives other drug solutions inside the beaker to stir, the stirring water column formed by the stirrer exists separately at the center of the beaker, which is not beneficial to uniformly stirring the drug solution deviated from the vertical line at the center of the beaker, and in the water bath heating type, the generated steam with high temperature makes the beaker placed inside a water bath pan shake, therefore, the stirring water column generated by the stirrer deviates, so that the medicine solution in the beaker is not convenient to stir under the stirring water column formed by the stirrer, and therefore, the magnetic stirring device for medicine analysis is provided.

Disclosure of Invention

The present invention is directed to a magnetic stirring device for drug analysis, which solves the problems of the background art described above.

In order to achieve the purpose, the invention provides the following technical scheme: magnetic stirring device for pharmaceutical analysis, including the magnetic stirrer, the magnetic stirrer top is connected with the water bath, and the inside beaker of having placed of water bath, it has temperature sensor to peg graft on the water bath, the inside stirring shell of having placed of beaker, and the stirring shell top is connected with the churn, the stirring shell is equipped with a plurality of weeping holes that are convenient for stir liquid and spill with the churn outside, the inside multiple spot stirring spare that carries out the stirring of many places to medicinal solution in the beaker that is equipped with of stirring shell, the beaker top is connected with the clamping piece of pressing from both sides tight beaker, and the clamping piece is connected with the water bath top, the churn top is connected with the lift piece of lift churn, is convenient for carry out the stirring simultaneously of many places with the inside medicinal solution of beaker.

Preferably, the multiple spot stirring piece is including placing the inside magnetic stirrer at the stirring shell, and magnetic stirrer magnetism is connected, the inside adapter sleeve that is equipped with of stirring shell, and magnetic stirrer pegs graft with the adapter sleeve, the stirring ring has been cup jointed in the adapter sleeve outside, and the first equidistance on the stirring ring is connected with a plurality of connecting rods, be connected with first stirring vane on the connecting rod, be convenient for stir the processing in stirring shell inside, stir when being convenient for realize the inside many departments of beaker.

Preferably, be connected with the puddler that distributes the multilayer on the churn, the puddler outside has cup jointed built-in stirring leaf, and built-in stirring leaf is located the churn inside, the puddler both ends are connected with second stirring rotary vane, are convenient for carry out the multilayer stirring with the medicinal solution in the churn outside.

Preferably, the clamping piece is including installing the oval mounting panel at water bath top oval mounting panel inboard is connected with and presss from both sides tight sponge, press from both sides tight sponge inner circle and cup joint with the beaker outside, and press from both sides tight sponge outside and be connected with a plurality of electronic push rods, and electronic push rod one end is connected with oval mounting panel top, is convenient for press from both sides the beaker outside tightly.

Preferably, the piece that goes up and down is including connecting the fixed plate at the churn top, the fixed plate both ends are connected with reset spring respectively, the reset spring bottom is connected with the contact lever, be connected with two magnet seats on the oval mounting panel, and two magnet seats are located the contact lever bottom respectively, magnet seat top is connected with spacing lagging, and contact lever one end slides and runs through spacing lagging, the contact lever slides the one end that runs through spacing lagging and is connected with the magnetic plate, and the magnetic plate is the magnetism of homopolar with the magnet seat, is convenient for keep going up and down the churn with magnetic stirrer and magnetic stirrer when adsorbing.

Preferably, the joint of the mixing drum and the mixing shell is in threaded connection, and the outer side of the mixing drum is connected with an anti-slip nut, so that the anti-slip of the mixing drum is facilitated.

Preferably, the multilayer stirring rods are respectively distributed in a staggered manner, so that the medicine solution in the beaker can be stirred in multiple layers in the stirring cylinder.

Preferably, the bottom of the connecting sleeve is connected with a metal block, the stirring shell is connected with a reset magnet, the reset magnet and the metal block are mutually adsorbed, and the connecting sleeve is conveniently reset to the original position after the stirring is finished.

Compared with the prior art, the invention has the beneficial effects that:

according to the invention, when a magnetic stirrer is used for stirring a medicine solution, the medicine is placed in the beaker, the arranged multipoint stirring piece is placed in the stirring shell, the stirring cylinder is connected and placed in the beaker, and the multipoint stirring piece is stirred in the stirring shell under the stirring action of the magnetic stirrer, so that the multipoint stirring of the solution in the beaker is conveniently realized, the top of the beaker is clamped by the arranged clamping piece, the shaking of the beaker caused by water bath heating is reduced, meanwhile, the lifting piece is arranged, the magnetic support which is the same as that of the magnetic stirrer is adopted, so that the magnetic stirrer is convenient to lift the stirring cylinder while adsorbing the magnetic stirrer for stirring, and the stirring cylinder is convenient to stir the solution in the beaker at a certain height.

Drawings

FIG. 1 is a schematic view of the overall structure of the present invention;

FIG. 2 is a schematic view of the backside structure of the present invention;

FIG. 3 is a schematic view of the present invention in partial cutaway configuration;

FIG. 4 is a schematic view of the clamp of the present invention;

FIG. 5 is a schematic view of the structure of the lifter of the present invention;

FIG. 6 is a schematic structural view of the integral mixing drum connected to the mixing shell according to the present invention;

FIG. 7 is a partial sectional structure diagram of the mixing drum of the present invention;

FIG. 8 is a schematic view of the structure of the stirring shell of the present invention;

FIG. 9 is a schematic view of the partial cutaway structure of FIG. 8;

FIG. 10 is a schematic view of the multi-point stirring member of the present invention.

In the figure: 1-a magnetic stirrer; 2-water bath; 3-beaker; 4-a temperature sensor; 5-stirring shell; 6-stirring cylinder; 7-weep holes; 8-a multipoint stirring member; 9-a clamping member; 10-a lifting member; 11-a magnetic stirrer; 12-a connecting sleeve; 13-stirring ring; 14-a connecting rod; 15-first stirring vane; 16-a stirring rod; 17-stirring blades are arranged in the reactor; 18-second stirring vane; 19-an oblong mounting plate; 20-clamping the sponge; 21-electric push rod; 22-a fixing plate; 23-a return spring; 24-contact bar; 25-electromagnet base; 26-a limit sleeve plate; 27-a magnetic plate; 28-slip nut; 29-metal block; 30-reset magnet.

Detailed Description

The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

Referring to fig. 1-10, the present invention provides a technical solution: the magnetic stirring device for the drug analysis mainly aims at the situation that when the existing magnetic stirrer 1 stirs the drug solution, the magnetic stirrer 11 forms a stirring water column located at the central position of the beaker 3 to stir the drug solution and is not beneficial to stirring the drug solution in the beaker 3 at multiple positions, the design in the scheme comprises the magnetic stirrer 1, the magnetic stirrer 1 is the magnetic stirrer 1 existing in the existing market, the magnetic stirrer 1 is generally internally provided with a motor, a motor and other driving devices connected with the built-in stirrer, a magnetic field is formed by the built-in stirrer, the magnetic stirrer 11 located in the beaker 3 can be conveniently adsorbed to carry out magnetic stirring, the top of the magnetic stirrer 1 is connected with a water bath pot 2, the beaker 3 is placed in the water bath pot 2, the water bath pot 2 is used for heating the drug solution in the beaker 3, and a heating pipe is arranged in the water bath pot 2, be convenient for stir the processing to the inside solution of water bath 2, it has temperature sensor 4 to peg graft on the water bath 2, beaker 3 inside has placed stirring shell 5, and the 5 top of stirring shell is connected with churn 6, stirring shell 5 is equipped with a plurality of weeping holes 7 that are convenient for stir liquid and spill with the churn 6 outside, and the design in weeping hole 7 mainly is for when magnetic stirrer 1 adsorbs magnetic stirrer 11 stirs, spills the solution of stirring from weeping hole 7, is convenient for stir simultaneously from the multiple spot, stirring shell 5 inside is equipped with carries out the multiple spot stirring 8 of multiple stirring to the medicine solution in beaker 3, beaker 3 top is connected with the clamping piece 9 of pressing from both sides tight beaker 3, and clamping piece 9 is connected with 2 tops of water bath, 6 tops of churn are connected with the lift 10 of lift churn 6.

When a worker needs to analyze the medicine, the medicine to be analyzed is placed in the beaker 3 to form a medicine solution, before stirring treatment, the cover body at the top of the water bath kettle 2 is opened, water is added into the water bath kettle 2 through a tap water pipe and the like, the added water is ensured to overflow the heating pipe in the water bath kettle 2, after the water is added, the temperature sensor 4 is inserted into the water bath kettle 2 through the insertion hole at the cover body of the water bath kettle 2, so that the water temperature in the water bath kettle 2 is convenient to detect, after the water is added, the beaker 3 is placed in the water bath kettle 2, the beaker 3 is clamped through the clamping piece 9, the multipoint stirring piece 8 is placed in the stirring shell 5, the stirring barrel 6 is spliced with the stirring shell 5, the lifting piece 10 at the top of the stirring barrel 6 is installed, after the beaker 3 is placed, through starting the magnetic stirrer 1, under the magnetic adsorption of the magnetic stirrer 1, the multipoint stirring piece 8 adsorbs and stirs in the stirring shell 5, and forms a plurality of strands of stirring water columns, and leaks from the liquid leakage hole 7, and the lifting piece 10 is convenient for stirring and adsorbing the multipoint stirring piece 8 under the same adsorption action as the magnetic stirrer 1, so that the stirring barrel 6 is lifted, and the stirring barrel 6 is stirred for the medicine solution in the beaker 3 at a certain height distance.

In the scheme, the multipoint stirring part 8 comprises a magnetic stirrer 11 placed inside a stirring shell 5, the magnetic stirrer 11 is magnetically connected with a magnetic stirrer 1, the magnetic stirrer 11 performs circular motion under the magnetic adsorption effect of the magnetic stirrer 1, so that magnetic stirring is realized, a connecting sleeve 12 is arranged inside the stirring shell 5, the magnetic stirrer 11 is spliced with the connecting sleeve 12, a stirring ring 13 is sleeved outside the connecting sleeve 12, a plurality of connecting rods 14 are connected to the stirring ring 13 at equal angles, a first stirring rotary vane 15 is connected to each connecting rod 14, a stirring rod 16 with multiple layers distributed is connected to the stirring barrel 6, a built-in stirring vane 17 is sleeved outside the stirring rod 16, the built-in stirring vane 17 is located inside the stirring barrel 6, second stirring rotary vanes 18 are connected to two ends of the stirring rod 16, the connecting sleeve 12, the magnetic stirrer 11 and the magnetic stirrer 1 are connected, and the magnetic stirrer 11 is connected with the connecting sleeve 12, The total gravity of the connecting rod 14 and the first stirring vane 15 is smaller than the adsorption force of the magnetic stirrer 1 to the magnetic stirrer 11, when the drug solution is stirred, the rotating speed of the magnetic stirrer 1 is adjusted to facilitate control of the rotating speed of the magnetic stirrer 11, thereby realizing different stirring speeds, under the adsorption action of the magnetic stirrer 1, the magnetic stirrer 11 starts to rotate, as the magnetic stirrer 11 is inserted into the connecting sleeve 12, when the magnetic stirrer 11 rotates, the connecting sleeve 12 is driven to perform circular motion, the outer side of the connecting sleeve 12 is connected with the stirring ring 13, and the stirring ring 13 is connected with a plurality of connecting rods 14, the connecting rod 14 is designed to be two-section type, the middle position thereof is connected with the first stirring vane 15, when the magnetic stirrer 11 performs circular motion stirring, the first stirring vane 15 on the stirring ring 13 is driven to perform circular motion, first stirring vane 15 and the medicine solution of here when contacting each other, be convenient for rotate the stirring, form horizontal stirring, the rotation of a plurality of connecting rods 14 simultaneously, be convenient for carry out many places stirring at 5 inside formation stranded stirring water columns of stirring shell, when the stirring water column that forms passes through churn 6, stirring water column and built-in stirring vane 17 contact each other, thereby make a plurality of puddlers 16 rotate, simultaneously because puddler 16 both ends are connected with second stirring vane 18 respectively, 16 rotation circumstances at the puddler, be convenient for realize the stirring rotation of second stirring

vane

18, 16 multilayer distributions of puddler in this scheme, be convenient for realize the multilayer stirring of 3 inside medicine solutions of beaker.

The clamping piece 9 comprises an oval-shaped mounting plate 19 arranged at the top of the water bath 2, a clamping sponge 20 is connected to the inner side of the oval-shaped mounting plate 19, the inner ring of the clamping sponge 20 is sleeved with the outer side of the beaker 3, and the outer side of the clamping sponge 20 is connected with a plurality of electric push rods 21, one end of each electric push rod 21 is connected with the top of the oval-shaped mounting plate 19, the two ends of the oval-shaped mounting plate 19 in the scheme are arranged on the cover body of the water bath kettle 2 through connecting pieces such as bolts and the like, before the beaker 3 is placed, the wall of the beaker 3 slides along the clamping sponge 20, after the beaker 3 is placed in the water inlet bath kettle 2, at the moment, the electric push rod 21 is started, the clamping sponge 20 starts to cling to the wall of the beaker 3 under the pushing action of the electric push rod 21, plays a role in clamping the beaker 3, avoids the beaker 3 from shaking due to the heat generated when the water bath 2 is heated, thereby avoiding the uneven stirring phenomenon caused by the magnetic stirrer 11 when the beaker 3 shakes.

The lifting member 10 is including connecting the fixed plate 22 at 6 tops of churn, fixed plate 22 both ends are connected with reset spring 23 respectively, reset spring 23 bottom is connected with contact rod 24, be connected with two magnet seats 25 on the ellipse mounting panel 19, and two magnet seats 25 are located contact rod 24 bottom respectively, magnet seat 25 top is connected with spacing lagging 26, and contact rod 24 one end slides and runs through spacing lagging 26, contact rod 24 slides and runs through the one end of spacing lagging 26 and is connected with magnetic sheet 27, and magnetic sheet 27 and magnet seat 25 are homopolar magnetism.

The method comprises the following specific operation steps: when the magnetic stirrer 11 is used for stirring under the adsorption effect of the magnetic stirrer 1, the electromagnet seat 25 is electrified, magnetism is formed at the top of the electromagnet seat 25, meanwhile, as the magnetic plate 27 is provided with magnetism, and the magnetism at the magnetic plate 27 is the same as that on the electromagnet seat 25, under the condition that the magnetism is repelled by the same row, the contact rod 24 connected to the top of the magnetic plate 27 is enabled to move upwards, and further the return spring 23 is extruded, the fixing plate 22 connected with the return spring 23 is pushed upwards, as the fixing plate 22 is connected with the top of the stirring cylinder 6, when the fixing plate 22 moves upwards, the stirring shell 5 connected with the stirring cylinder 6 and the stirring cylinder 6 is driven to move upwards, so as to stir at a certain height, when the contact rod 24 extrudes the return spring 23 until the magnetic plate 27 and the electromagnet seat 25 are not repelled mutually, the pushing force is lost, under the effect of reset spring 23 for contact bar 24 downstream to repeated realization is to the lift of churn 6, and the mutual repulsion force dynamics scope between magnetic plate 27 and electromagnet seat 25 should not be more than the power degree value of magnetic stirrer 1 to magnetic stirrer 11 adsorption affinity in this scheme, makes churn 6 do not influence the adsorption stirring of magnetic stirrer 1 to magnetic stirrer 11 when ejecting the restoration.

The mixing drum 6 is in threaded connection with the mixing shell 5, an anti-slip nut 28 is connected to the outer side of the mixing drum 6, and the phenomenon of wire slipping between the mixing shell 5 and the mixing drum 6 is avoided through fastening of the anti-slip nut 28.

The plurality of layers of stirring rods 16 are respectively distributed in a staggered manner, so that the medicine solution in the beaker 3 can be stirred from a plurality of positions.

The adapter sleeve 12 bottom is connected with metal block 29, be connected with the magnetite 30 that resets on the stirring shell 5, and the magnetite 30 that resets and metal block 29 mutual adsorption, after the stirring, with the disconnection of magnetic stirrer 1, magnetic stirrer 11 loses magnetic force and adsorbs this moment, there is adapter sleeve 12 bottom to be connected with metal block 29, under the adsorption effect of the magnetite 30 that resets, be convenient for adsorb adapter sleeve 12 to the magnetite 30 department that resets, the staff of being convenient for takes out magnetic stirrer 11 from adapter sleeve 12, the adsorption affinity of the magnetite 30 that resets of design to metal block 29 in this scheme is far less than magnetic stirrer 1 to magnetic stirrer 11.

It is noted that, herein, relational terms such as first and second, and the like may be used solely to distinguish one entity or action from another entity or action without necessarily requiring or implying any actual such relationship or order between such entities or actions. Also, the terms "comprises," "comprising," or any other variation thereof, are intended to cover a non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements does not include only those elements but may include other elements not expressly listed or inherent to such process, method, article, or apparatus.

Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.

Claims

1. Magnetism agitating unit for pharmaceutical analysis, including magnetism agitator (1), magnetism agitator (1) top is connected with water bath (2), and inside beaker (3) of having placed of water bath (2), it has temperature sensor (4), its characterized in that to peg graft on water bath (2): the stirring shell (5) is placed in the beaker (3), the top of the stirring shell (5) is connected with a stirring cylinder (6), a plurality of liquid leakage holes (7) which are convenient for the leakage of the stirring liquid are formed in the outer sides of the stirring shell (5) and the stirring cylinder (6), a multi-point stirring piece (8) which can stir the medicine solution in the beaker (3) in a plurality of positions is arranged in the stirring shell (5), the top of the beaker (3) is connected with a clamping piece (9) which clamps the beaker (3), the clamping piece (9) is connected with the top of the water bath kettle (2), the top of the stirring cylinder (6) is connected with a lifting piece (10) of the lifting stirring cylinder (6), the multi-point stirring piece (8) comprises a magnetic stirrer (11) placed in the stirring shell (5), the magnetic stirrer (11) is magnetically connected with the magnetic stirrer (1), and a connecting sleeve (12) is arranged in the stirring shell (5), and magnetism stirring son (11) are pegged graft with adapter sleeve (12), adapter sleeve (12) outside has cup jointed stirring ring (13), and wait for angle connection on stirring ring (13) have a plurality of connecting rods (14), be connected with first stirring rotary vane (15) on connecting rod (14), be connected with on churn (6) and distribute multilayer puddler (16), built-in stirring leaf (17) have been cup jointed in puddler (16) outside, and built-in stirring leaf (17) are located inside churn (6), puddler (16) both ends are connected with second stirring rotary vane (18).

2. The magnetic stirring device for pharmaceutical analysis according to claim 1, wherein: clamping piece (9) are including installing oval mounting panel (19) at water bath (2) top oval mounting panel (19) inboard is connected with presss from both sides tight sponge (20), press from both sides tight sponge (20) inner circle and cup joint with beaker (3) outside, and press from both sides tight sponge (20) outside and be connected with a plurality of electronic push rods (21), and electronic push rod (21) one end is connected with oval mounting panel (19) top.

3. The magnetic stirring device for pharmaceutical analysis according to claim 2, wherein: lifting member (10) is including connecting fixed plate (22) at churn (6) top, fixed plate (22) both ends are connected with reset spring (23) respectively, reset spring (23) bottom is connected with contact arm (24), be connected with two magnet bases (25) on ellipse shape mounting panel (19), and two magnet bases (25) are located contact arm (24) bottom respectively, magnet base (25) top is connected with spacing lagging (26), and contact arm (24) one end slides and runs through spacing lagging (26), contact arm (24) slide the one end that runs through spacing lagging (26) and be connected with magnetic plate (27), and magnetic plate (27) and magnet base (25) are the magnetism of the same utmost point.

4. The magnetic stirring device for pharmaceutical analysis according to claim 1, wherein: the mixing drum (6) is in threaded connection with the mixing shell (5), and an anti-slip nut (28) is connected to the outer side of the mixing drum (6).

5. The magnetic stirring device for pharmaceutical analysis according to claim 1, wherein: the stirring rods (16) distributed in multiple layers are respectively distributed in a staggered manner.

6. The magnetic stirring device for pharmaceutical analysis according to claim 1, wherein: the bottom of the connecting sleeve (12) is connected with a metal block (29), the stirring shell (5) is connected with a reset magnet (30), and the reset magnet (30) and the metal block (29) are mutually adsorbed.