CN1116297C - Method for preparing sodium amoxicillin - Google Patents
Method for preparing sodium amoxicillin Download PDFInfo
- Publication number
- CN1116297C CN1116297C CN 00100579 CN00100579A CN1116297C CN 1116297 C CN1116297 C CN 1116297C CN 00100579 CN00100579 CN 00100579 CN 00100579 A CN00100579 A CN 00100579A CN 1116297 C CN1116297 C CN 1116297C
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- Prior art keywords
- sodium
- dehydrated alcohol
- filtration
- washing
- amoxicillin
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- 238000000034 method Methods 0.000 title claims abstract description 18
- BYHDFCISJXIVBV-YWUHCJSESA-M amoxicillin sodium Chemical compound [Na+].C1([C@@H](N)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C([O-])=O)(C)C)=CC=C(O)C=C1 BYHDFCISJXIVBV-YWUHCJSESA-M 0.000 title 1
- 238000001914 filtration Methods 0.000 claims abstract description 23
- 238000005406 washing Methods 0.000 claims abstract description 21
- 239000002253 acid Substances 0.000 claims abstract description 17
- 239000000047 product Substances 0.000 claims abstract description 14
- ILVPFTMKCHREDJ-UHFFFAOYSA-N methyl 5-amino-2-fluorobenzoate Chemical compound COC(=O)C1=CC(N)=CC=C1F ILVPFTMKCHREDJ-UHFFFAOYSA-N 0.000 claims abstract description 13
- 229960002793 amoxicillin sodium Drugs 0.000 claims abstract description 12
- 238000002425 crystallisation Methods 0.000 claims abstract description 12
- 230000008025 crystallization Effects 0.000 claims abstract description 9
- 238000001035 drying Methods 0.000 claims abstract description 4
- 229910052708 sodium Inorganic materials 0.000 claims description 25
- 239000011734 sodium Substances 0.000 claims description 25
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 24
- OEOIWYCWCDBOPA-UHFFFAOYSA-N 6-methyl-heptanoic acid Chemical compound CC(C)CCCCC(O)=O OEOIWYCWCDBOPA-UHFFFAOYSA-N 0.000 claims description 22
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 21
- 238000006243 chemical reaction Methods 0.000 claims description 21
- 229960000935 dehydrated alcohol Drugs 0.000 claims description 21
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 20
- 150000004684 trihydrates Chemical class 0.000 claims description 16
- 239000000243 solution Substances 0.000 claims description 14
- JJWLVOIRVHMVIS-UHFFFAOYSA-N isopropylamine Chemical compound CC(C)N JJWLVOIRVHMVIS-UHFFFAOYSA-N 0.000 claims description 13
- 239000000178 monomer Substances 0.000 claims description 13
- 229920002554 vinyl polymer Polymers 0.000 claims description 13
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims description 12
- 239000000706 filtrate Substances 0.000 claims description 12
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 claims description 12
- 238000002360 preparation method Methods 0.000 claims description 11
- 238000003756 stirring Methods 0.000 claims description 9
- 239000006210 lotion Substances 0.000 claims description 8
- 239000011259 mixed solution Substances 0.000 claims description 7
- 239000002994 raw material Substances 0.000 claims description 6
- 238000011146 sterile filtration Methods 0.000 claims description 5
- 229910052799 carbon Inorganic materials 0.000 claims description 4
- 238000011045 prefiltration Methods 0.000 claims description 4
- 230000001954 sterilising effect Effects 0.000 claims description 4
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 3
- 238000002156 mixing Methods 0.000 claims description 3
- 238000010926 purge Methods 0.000 claims description 3
- LSQZJLSUYDQPKJ-NJBDSQKTSA-N amoxicillin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C(O)=O)(C)C)=CC=C(O)C=C1 LSQZJLSUYDQPKJ-NJBDSQKTSA-N 0.000 abstract description 7
- 229960003022 amoxicillin Drugs 0.000 abstract description 6
- LSQZJLSUYDQPKJ-UHFFFAOYSA-N p-Hydroxyampicillin Natural products O=C1N2C(C(O)=O)C(C)(C)SC2C1NC(=O)C(N)C1=CC=C(O)C=C1 LSQZJLSUYDQPKJ-UHFFFAOYSA-N 0.000 abstract description 6
- 239000012535 impurity Substances 0.000 abstract description 2
- UAOMVDZJSHZZME-UHFFFAOYSA-N diisopropylamine Chemical compound CC(C)NC(C)C UAOMVDZJSHZZME-UHFFFAOYSA-N 0.000 abstract 3
- 239000007795 chemical reaction product Substances 0.000 abstract 1
- 229940043279 diisopropylamine Drugs 0.000 abstract 1
- FUGVTYHNTOTQMG-UHFFFAOYSA-M sodium;6-methylheptanoate Chemical compound [Na+].CC(C)CCCCC([O-])=O FUGVTYHNTOTQMG-UHFFFAOYSA-M 0.000 abstract 1
- 235000015424 sodium Nutrition 0.000 description 19
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 8
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical class CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 description 7
- 239000000843 powder Substances 0.000 description 5
- 239000002904 solvent Substances 0.000 description 4
- SJRJJKPEHAURKC-UHFFFAOYSA-N N-Methylmorpholine Chemical compound CN1CCOCC1 SJRJJKPEHAURKC-UHFFFAOYSA-N 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 150000001412 amines Chemical class 0.000 description 3
- 239000013068 control sample Substances 0.000 description 3
- 230000007812 deficiency Effects 0.000 description 3
- QMWWAEFYIXXXQW-UHFFFAOYSA-M potassium;2-[(4-ethoxy-4-oxobut-2-en-2-yl)amino]-2-phenylacetate Chemical compound [K+].CCOC(=O)C=C(C)NC(C([O-])=O)C1=CC=CC=C1 QMWWAEFYIXXXQW-UHFFFAOYSA-M 0.000 description 3
- JVSFQJZRHXAUGT-UHFFFAOYSA-N 2,2-dimethylpropanoyl chloride Chemical compound CC(C)(C)C(Cl)=O JVSFQJZRHXAUGT-UHFFFAOYSA-N 0.000 description 2
- NGHVIOIJCVXTGV-ALEPSDHESA-N 6-aminopenicillanic acid Chemical compound [O-]C(=O)[C@H]1C(C)(C)S[C@@H]2[C@H]([NH3+])C(=O)N21 NGHVIOIJCVXTGV-ALEPSDHESA-N 0.000 description 2
- NGHVIOIJCVXTGV-UHFFFAOYSA-N 6beta-amino-penicillanic acid Natural products OC(=O)C1C(C)(C)SC2C(N)C(=O)N21 NGHVIOIJCVXTGV-UHFFFAOYSA-N 0.000 description 2
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- 150000008065 acid anhydrides Chemical class 0.000 description 2
- 150000001298 alcohols Chemical class 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- PQLFROTZSIMBKR-UHFFFAOYSA-N ethenyl carbonochloridate Chemical compound ClC(=O)OC=C PQLFROTZSIMBKR-UHFFFAOYSA-N 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- -1 methyl acetyl Chemical group 0.000 description 2
- 238000010189 synthetic method Methods 0.000 description 2
- 229940086542 triethylamine Drugs 0.000 description 2
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 229930182555 Penicillin Natural products 0.000 description 1
- JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 description 1
- 208000026935 allergic disease Diseases 0.000 description 1
- 230000007815 allergy Effects 0.000 description 1
- 150000008064 anhydrides Chemical class 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 239000003054 catalyst Substances 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 238000005352 clarification Methods 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000004108 freeze drying Methods 0.000 description 1
- 230000007062 hydrolysis Effects 0.000 description 1
- 238000006460 hydrolysis reaction Methods 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 229940049954 penicillin Drugs 0.000 description 1
- 239000002574 poison Substances 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 239000012716 precipitator Substances 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 238000001694 spray drying Methods 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The present invention relates to a preparing method of amoxicillin sodium. In the preparing method, firstly trihydrated acid of amoxicillin reacts with diisopropyl amine, then a reaction product is purified to react with purified sodium isocaprylate, and finally a finished product is obtained by crystallization, filtration, washing and drying. The preparing method of amoxicillin sodium provided by the present invention is scientific, reasonable, simple and practical, and has the advantages of stable product quality and performance, high content, few impurities, difficult allergm, etc.
Description
The present invention relates to the preparation method of the synthetic method of Western medicine, particularly a kind of Amoxicillin Sodium.
The amoxycilline Trihydrate bp is the semisynthetic penicillin of Britain BEECHAM company initiative; the patent of the method after existing so far a lot of relevant Amoxicillin synthetic method and the improvement thereof; but it is the same with principle in the disquisition of publishing in 1978 to carry out the most frequently used method of scale operation at present; amine was protected in the amino of D-(-)-P-glycin and the reaction of methyl acetyl triethyl formed, and generated Dane salt.Remove separated from solvent and go out Dane salt solid; be suspended from acetone or the methylene dichloride; under-10-50 ℃ and basic catalyst such as N-methylmorpholine effect with Vinyl chloroformate or trimethyl-acetyl chloride reaction; form mixed acid anhydride; add 6-amino-penicillanic acid (6-APA) in the dichloromethane solvent of triethyl amine salt; the reaction back generates the protected Amoxicillin of N-; add water and hydrochloric acid under 0 ℃; the pH value is adjusted to 1.5-2.5; amine hydrolysis in making; remove dichloromethane layer, re-adjustment aqueous pH values to 5 (iso-electric point), the amoxycillin of three brilliant water can be separated out.Most producers prepare Dane salt with potassio for sodium, replace Vinyl chloroformate to prepare mixed acid anhydride with trimethyl-acetyl chloride.
The production method of Amoxicillin Sodium salt has two kinds, a kind of be suspended from the amoxycillin trihydrate in the water or the mixed solution of water and Virahol in, add sodium hydroxide solution and make its dissolving, isolate sodium salt by freeze-drying or spray-drying process, it is low that this method exists product content, and degradation material content height, product easily produce the deficiency of aspects such as allergy; Another kind method is the precipitator method, be about to be dissolved with in the solvent of Sodium isooctanoate such as the amine organic solvent such as triethylamine that Virahol is added to Amoxicillin, this method exist used triethylamine equal solvent poison pay effect strong, be unfavorable for deficiency such as workman's labour protection.
The objective of the invention is to overcome the preparation method that the deficiencies in the prior art provide a kind of quality product height, the simple Amoxicillin Sodium of aftertreatment.
The preparation method of Amoxicillin Sodium of the present invention comprises and will carry out purifying after amoxycilline Trihydrate bp three water acid elder generation and the two Isopropylamines reaction, obtains finished product again with the Sodium isooctanoate reaction that purifying is good, and through crystallization, filtration, washing, drying.
Wherein, described amoxycilline Trihydrate bp three water acid is to carry out in the presence of dehydrated alcohol, Virahol with the reactions of two Isopropylamines, treats that amoxycilline Trihydrate bp three water acid dissolve postcooling fully to 0-5 ℃; Wherein, described each raw materials in part by weight proportioning is: 35 parts of amoxycilline Trihydrate bp three water acid
Dehydrated alcohol 77.4-9.5 part
Two Isopropylamine 24-26 parts
Virahol 62.8-6.3 part
The purifying of described Sodium isooctanoate comprises Sodium isooctanoate is dissolved in the mixing solutions of vinyl acetic monomer and dehydrated alcohol, obtains the Sodium isooctanoate that filtrate promptly gets purifying after filtration, and is kept under 18-22 ℃ the temperature; Wherein, described each raw materials in part by weight proportioning is:
Sodium isooctanoate 21.5-23.5 part
Vinyl acetic monomer 8.9-12.5 part
Dehydrated alcohol 148-152 part
The filtration of described Sodium isooctanoate can be carried out in prefilter and sterilizing filter, and Sodium isooctanoate passes through during with the dehydrated alcohol washing and filtering place, merging filtrate and washing lotion.
The purge process of the reaction solution of the three water acid of described amoxycilline Trihydrate bp and two Isopropylamines is included in and adds gac in the reaction solution, through carbon removal filtration and sterile filtration, and the place that reaction solution passes through during with the mixed solution washing and filtering of dehydrated alcohol and Virahol, merging filtrate and washing lotion, and maintain the temperature at 13-17 ℃.
Described crystallisation process is under-2-2 ℃ temperature, stirs 80-100 minute under 80-120 rev/min stirring velocity.
Described washing process is that the crystallization that filtration obtains is washed 2-3 time with vinyl acetic monomer, obtains pure crystallisate.
The preparation method of Amoxicillin Sodium of the present invention is scientific and reasonable, and is simple, has products obtained therefrom content height, advantage that impurity is few.
The product that adopts preparation method of the present invention to make is carried out the quality approach test:
1, for test agent: our company's trial-production, lot number: 990506,990507,990508
2, control sample: domestic certain factory's product, lot number: 990105
3, test method and project
According to the every requirement under 1995 editions 1997 [Amoxicillin Sodiums of the Chinese Pharmacopoeia item, carry out complete check to trial-product (three batches) and control sample are a collection of.
Every test-results is seen attached list:
Project appearance character specific optical rotation is differentiated the relevant moisture content of basicity
(PH) material (%) (%) (%)
Control sample off-white color crystalline powder+250 °-8.9 6.09 3.8 84.8
990506 off-white color crystalline powder+252 °-9.0 2.5 3.0 88.4
990507 off-white color crystalline powder+252 °-9.1 2.3 2.6 88.5
990508 off-white color crystalline powder+252 °-9.2 2.1 2.7 88.4
Conclusion: quality approach proves that products made thereby quality of the present invention reaches the requirement of 1995 editions 1997 [s of Pharmacopoeia of People's Republic of China fully, and is not less than by imitation.
Further describe the present invention below in conjunction with embodiment
Embodiment
A kind of preparation method of Amoxicillin Sodium, it comprises carries out purifying earlier with after two Isopropylamine reactions with the acid of amoxycilline Trihydrate bp three water, obtains finished product again with the Sodium isooctanoate reaction that purifying is good, and through crystallization, filtration, washing, drying.
Wherein, described amoxycilline Trihydrate bp three water acid is to carry out in the presence of dehydrated alcohol, Virahol with the reactions of two Isopropylamines, treats that amoxycilline Trihydrate bp three water acid dissolve postcooling to 3 ℃ fully; Wherein, described each raw materials in part by weight proportioning is: 1 part of amoxycilline Trihydrate bp three water acid
0.7143 part of two Isopropylamine
2.2114 parts of dehydrated alcohols
1.793 parts of Virahols
The purifying of described Sodium isooctanoate comprises Sodium isooctanoate is dissolved in the mixing solutions of vinyl acetic monomer and dehydrated alcohol, obtains the Sodium isooctanoate that filtrate promptly gets purifying after filtration, and is kept under 20 ℃ the temperature; Wherein, described each raw materials in part by weight proportioning is:
22.5 parts of Sodium isooctanoates
12.5 parts of vinyl acetic monomers
150 parts of dehydrated alcohols
The filtration of described Sodium isooctanoate can be carried out in prefilter and sterilizing filter, and Sodium isooctanoate passes through during with the dehydrated alcohol washing and filtering place, merging filtrate and washing lotion.
The purge process of the reaction solution of the three water acid of described amoxycilline Trihydrate bp and two Isopropylamines is included in and adds gac in the reaction solution, through carbon removal filtration and sterile filtration, and the place that reaction solution passes through during with the mixed solution washing and filtering of dehydrated alcohol and Virahol, merging filtrate and washing lotion, and maintain the temperature at 15 ℃.
Described crystallisation process is under 0 ℃ of temperature, stirs 80-100 minute under 100 rev/mins stirring velocity.
Described washing process is that the crystallization that filtration obtains is washed 2 times with vinyl acetic monomer, obtains pure crystallisate.
Detailed process is: Sodium isooctanoate is dissolved in the mixed solution of vinyl acetic monomer and dehydrated alcohol, filter through prefilter and sterilizing filter, and wash the filtration line with 10L dehydrated alcohol top, and it is stand-by that filtrate and washing lotion together enter the sterilisable chamber high level tank, and holding temperature is 20 ℃.
Three water acid are dissolved in the mixed solution of dehydrated alcohol, Virahol and two Isopropylamines, wait to dissolve complete postcooling to 3 ℃, it is an amount of to add gac, filter and sterile filtration through de-carbon, filtrate is advanced the sterilisable chamber crystallizer, the filtration line is washed on mixed solution top with dehydrated alcohol and Virahol, and the temperature that keeps crystallizer is at 15 ℃.
Different sodium solution in the high level tank along with stirring joins in the crystallizer, is added crystal seed, and crystallization begins to produce, and the stirring velocity that slows down is cooled to 0 ℃ ℃, stirs 90 minutes.
The 10L vinyl acetic monomer is entered the sterilisable chamber high level tank after sterile filtration stand-by, and the crystallization in the crystallizer is filtered, and washs secondary with vinyl acetic monomer, and filtrate and washing lotion are sent receipts back to, and product send dry place dry.
Described amoxycilline Trihydrate bp three water acid outward appearance is white in color or the off-white color crystalline powder, and is up to specification during discriminating, content: 〉=95% (pressing anhydride calculates), moisture: 12-15%.
Described pair of Isopropylamine outward appearance is achromaticity and clarification liquid, content 〉=95%, moisture.Divide≤0.5%, refractive index is 1.3924.
The outward appearance of vinyl acetic monomer is a colourless transparent liquid, content 〉=95%, and moisture content≤0.3%, refractive index are 1.3719.
The content of dehydrated alcohol is 〉=99.7%, moisture＜0.3%.
Claims (4)
1, a kind of preparation method of Amoxicillin Sodium is characterized in that comprising three water acid in amoxycilline Trihydrate bp is carried out purifying earlier with after two Isopropylamine reactions, obtains finished product again with the Sodium isooctanoate reaction that purifying is good, and through crystallization, filtration, washing, drying;
Wherein, described amoxycilline Trihydrate bp three water acid is to carry out in the presence of dehydrated alcohol and Virahol with the reactions of two Isopropylamines, treats that amoxycilline Trihydrate bp three water acid dissolve postcooling fully to 0-5 ℃; Described each raw materials in part by weight proportioning is as follows:
35 parts of amoxycilline Trihydrate bp three water acid
Dehydrated alcohol 77.4-9.5 part
Two Isopropylamine 24-26 parts
Virahol 62.8-6.3 part;
The purge process of reacted reaction solution is included in and adds gac in the reaction solution, through carbon removal filtration and sterile filtration, and the place that reaction solution passes through during with the mixed solution washing and filtering of dehydrated alcohol and Virahol, merging filtrate and washing lotion, and maintain the temperature at 13-17 ℃;
The purifying of described Sodium isooctanoate comprises Sodium isooctanoate is dissolved in the mixing solutions of vinyl acetic monomer and dehydrated alcohol, obtains the Sodium isooctanoate that filtrate promptly gets purifying after filtration, and is kept under 18-22 ℃ the temperature; Wherein, described each raw materials in part by weight proportioning is:
Sodium isooctanoate 21.5-23.5 part
Vinyl acetic monomer 8.9-12.5 part
Dehydrated alcohol 148-152 part.
2, the preparation method of Amoxicillin Sodium as claimed in claim 1 is characterized in that the filtration of described Sodium isooctanoate is carried out in prefilter and sterilizing filter, and Sodium isooctanoate passes through during with the dehydrated alcohol washing and filtering place, merging filtrate and washing lotion.
3, the preparation method of Amoxicillin Sodium as claimed in claim 1 is characterized in that described crystallisation process is under-2-2 ℃ temperature, stirs 80-100 minute under 80-120 rev/min stirring velocity.
4, the preparation method of Amoxicillin Sodium as claimed in claim 1 is characterized in that described washing process is that the crystallization that filter obtains is washed 2-3 time with vinyl acetic monomer, obtains pure crystallisate.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 00100579 CN1116297C (en) | 2000-01-26 | 2000-01-26 | Method for preparing sodium amoxicillin |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 00100579 CN1116297C (en) | 2000-01-26 | 2000-01-26 | Method for preparing sodium amoxicillin |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1306962A CN1306962A (en) | 2001-08-08 |
| CN1116297C true CN1116297C (en) | 2003-07-30 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 00100579 Expired - Fee Related CN1116297C (en) | 2000-01-26 | 2000-01-26 | Method for preparing sodium amoxicillin |
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| Country | Link |
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Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102268016A (en) * | 2011-03-28 | 2011-12-07 | 哈药集团制药总厂 | Method for preparing amoxicillin sodium |
| CN111205306A (en) * | 2020-03-06 | 2020-05-29 | 山东二叶制药有限公司 | Preparation process of amoxicillin sodium |
| CN116396307A (en) * | 2023-04-04 | 2023-07-07 | 内蒙古联邦动保药品有限公司 | Preparation method of amoxicillin sodium |
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2000
- 2000-01-26 CN CN 00100579 patent/CN1116297C/en not_active Expired - Fee Related
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| Publication number | Publication date |
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| CN1306962A (en) | 2001-08-08 |
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