CN111381064B - In-vitro diagnosis analyzer and method for improving use efficiency of sample rack - Google Patents
In-vitro diagnosis analyzer and method for improving use efficiency of sample rack Download PDFInfo
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- CN111381064B CN111381064B CN201811628179.XA CN201811628179A CN111381064B CN 111381064 B CN111381064 B CN 111381064B CN 201811628179 A CN201811628179 A CN 201811628179A CN 111381064 B CN111381064 B CN 111381064B
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- 238000000338 in vitro Methods 0.000 title claims abstract description 39
- 238000000034 method Methods 0.000 title claims abstract description 26
- 238000003745 diagnosis Methods 0.000 title claims abstract description 16
- 238000003908 quality control method Methods 0.000 claims abstract description 352
- 238000012360 testing method Methods 0.000 claims abstract description 151
- 230000003993 interaction Effects 0.000 claims description 29
- 230000000007 visual effect Effects 0.000 claims description 5
- 239000000523 sample Substances 0.000 description 143
- 239000003153 chemical reaction reagent Substances 0.000 description 28
- 230000007246 mechanism Effects 0.000 description 12
- 238000006243 chemical reaction Methods 0.000 description 9
- 238000004458 analytical method Methods 0.000 description 6
- 230000008901 benefit Effects 0.000 description 6
- 238000001514 detection method Methods 0.000 description 6
- 238000012986 modification Methods 0.000 description 6
- 230000004048 modification Effects 0.000 description 6
- 230000006870 function Effects 0.000 description 5
- 238000002347 injection Methods 0.000 description 5
- 239000007924 injection Substances 0.000 description 5
- 239000000463 material Substances 0.000 description 5
- 230000008569 process Effects 0.000 description 5
- 238000004590 computer program Methods 0.000 description 4
- 238000010586 diagram Methods 0.000 description 4
- 238000012545 processing Methods 0.000 description 4
- 238000005070 sampling Methods 0.000 description 4
- 238000003018 immunoassay Methods 0.000 description 3
- 230000003287 optical effect Effects 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- 230000008878 coupling Effects 0.000 description 2
- 238000010168 coupling process Methods 0.000 description 2
- 238000005859 coupling reaction Methods 0.000 description 2
- 238000004020 luminiscence type Methods 0.000 description 2
- 239000013610 patient sample Substances 0.000 description 2
- 210000004381 amniotic fluid Anatomy 0.000 description 1
- 239000000427 antigen Substances 0.000 description 1
- 102000036639 antigens Human genes 0.000 description 1
- 108091007433 antigens Proteins 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000012742 biochemical analysis Methods 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 210000001175 cerebrospinal fluid Anatomy 0.000 description 1
- 238000004891 communication Methods 0.000 description 1
- 230000002354 daily effect Effects 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 238000007885 magnetic separation Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 210000002381 plasma Anatomy 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
- G01N35/04—Details of the conveyor system
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/00584—Control arrangements for automatic analysers
- G01N35/00722—Communications; Identification
- G01N35/00732—Identification of carriers, materials or components in automatic analysers
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
Abstract
According to the in-vitro diagnosis analyzer and the method for improving the service efficiency of the sample rack, the identity mark of the target quality control calibration rack is obtained by scanning the target quality control calibration rack entering the in-vitro diagnosis analyzer; the identity of the target quality control calibration frame is associated with preset quality control settings and calibration settings; acquiring an associated quality control test application or a calibration test application according to the identity of the target quality control calibration frame; when a quality control test application is associated, enabling the associated quality control setting of the target quality control calibration frame to perform corresponding quality control test according to the identity of the target quality control calibration frame; when a calibration test application is associated, enabling the associated calibration setting of the target quality control calibration frame according to the identity of the target quality control calibration frame to perform a corresponding calibration test. Therefore, the quality control calibration frame can be used for both quality control test and calibration test, multiplexing of the sample frame is realized, and the use efficiency of the sample frame is improved.
Description
Technical Field
The invention relates to the field of medical equipment, in particular to an in-vitro diagnosis analyzer and a method for improving the use efficiency of a sample rack.
Background
For in-vitro diagnostic analyzers with large test throughput, sample introduction by a sample holder is an indispensable ring. Within the industry, sample holders are typically identical in structure, but differ in color, barcode type. For example, a sample rack of a particular color can only be used for a particular type of test, such as a conventional rack can only be used for conventional tests; the calibration rack is used for placing calibration products, the bar code of the calibration rack is usually started by S, other types of racks are distinguished, and the calibration rack can only be used for calibration test; the quality control rack is used for placing quality control products, and the bar code of the quality control rack is usually started by C, so that other types of racks can be distinguished, and the quality control rack can only be used for quality control testing. For a biochemical analyzer or an immunity analyzer of a rack type sample injection, a manufacturer can provide a conventional rack, a calibration rack, a quality control rack and the like to support users to perform different tests.
Wherein, the quality control test is generally carried out daily by a clinical laboratory to monitor whether the quality of the instrument reagent system is out of control.
The reagents used by the biochemical analyzer or the immunoassay analyzer have certain differences among different batches, so that a user generally uses a calibration product produced by a manufacturer to perform calibration test after replacing the reagent batch so as to obtain the parameters of the batch of reagents.
It can be seen that the probability of using a calibration frame purchased by a user is very small, and is generally only used when reagents are replaced in batches. In most of the time, the calibration frame is in an idle state, so that resource waste is caused, and the purchase cost of a user is increased.
Disclosure of Invention
The invention mainly provides an in-vitro diagnosis analyzer and a method for improving the use efficiency of a sample rack, aiming at improving the use efficiency of the sample rack.
An embodiment provides a method for improving the service efficiency of a sample rack, which comprises the following steps:
scanning a target quality control calibration frame entering the in-vitro diagnostic analyzer to obtain an identity of the target quality control calibration frame; the identity of the target quality control calibration frame is associated with preset quality control settings and calibration settings;
acquiring an associated quality control test application or a calibration test application according to the identity of the target quality control calibration frame;
when a quality control test application is associated, enabling the associated quality control setting of the target quality control calibration frame to perform corresponding quality control test according to the identity of the target quality control calibration frame; and when a calibration test application is associated, enabling the associated calibration setting of the target quality control calibration frame to perform a corresponding calibration test according to the identity of the target quality control calibration frame.
In one embodiment, the quality control arrangement comprises: the target quality control calibration frame is used as a target sample position for quality control test and a test item to be executed for the target sample position; the calibration settings include: the target quality control calibration frame is used as a target sample position for calibration test and a test item to be executed by the target sample position.
In one embodiment, scanning a target quality control calibration frame entering an in-vitro diagnostic analyzer, and before obtaining an identity of the target quality control calibration frame, including:
acquiring quality control product information or calibrator information in an input or scanning mode; the quality control product information at least comprises identification of a quality control product and a quality control test item, and the calibrator information at least comprises identification of a calibrator and a calibration test item;
receiving a selection signal for selecting the identity of a target quality control calibration frame or the identity of the input target quality control calibration frame, and determining the quality control product or the target quality control calibration frame in which the calibration product is placed according to the selection signal or the identity;
receiving a selection signal or an input sample bit identifier for selecting the sample bit identifier, and determining a target sample bit for placing a quality control product or a calibrator according to the selection signal or the sample bit identifier;
correlating the identification of the quality control product, the quality control test project, the identification of the target quality control calibration frame and the sample position identification of the target sample position to obtain the quality control setting of the target quality control calibration frame; and correlating the identification of the calibrator, the calibration test item, the identification of the target quality control calibration frame and the sample position identification of the target sample position to obtain the calibration setting of the target quality control calibration frame.
In one embodiment, the method further includes, before scanning the target quality control calibration frame entering the in-vitro diagnostic analyzer to obtain the identity of the target quality control calibration frame:
receiving an application of performing quality control test by using the target quality control calibration frame, associating the identity of the target quality control calibration frame with the quality control test application, and setting different quality control products at different target sample positions and corresponding to the associated quality control test items; receiving an application for performing calibration test by using the target quality control calibration frame, associating the identity of the target quality control calibration frame with the calibration test application, and setting different calibration products at different target sample positions and corresponding to the associated calibration test items; the test type associated with the same identity is unique.
In one embodiment, the method further comprises:
and after the quality control test is finished, the association between the identification mark of the target quality control calibration frame and the quality control test application is released, and after the calibration test is finished, the association between the identification mark of the target quality control calibration frame and the calibration test application is released.
One embodiment provides an in vitro diagnostic analyzer comprising:
the scanning device is used for scanning the sample rack to obtain the identity mark of the sample rack; the sample rack comprises a quality control calibration rack, wherein the identity of the target quality control calibration rack is associated with preset quality control settings and calibration settings;
the testing device is used for testing the samples in the sample rack;
the processor is used for scanning the target quality control calibration frame entering the in-vitro diagnosis analyzer through the scanning device to obtain the identity of the target quality control calibration frame; acquiring an associated quality control test application or a calibration test application according to the identity of the target quality control calibration frame; when a quality control test application is associated, enabling the associated quality control setting of the target quality control calibration frame to perform corresponding quality control test according to the identity of the target quality control calibration frame; and when a calibration test application is associated, enabling the associated calibration setting of the target quality control calibration frame to perform a corresponding calibration test according to the identity of the target quality control calibration frame.
In one embodiment, the quality control arrangement comprises: the target quality control calibration frame is used as a target sample position for quality control test and a test item to be executed for the target sample position; the calibration settings include: the target quality control calibration frame is used as a target sample position for calibration test and a test item to be executed by the target sample position.
In one embodiment, the system further comprises a man-machine interaction device for receiving visual information input and output by an operator; the processor is further configured to:
scanning a target quality control calibration frame entering the in-vitro diagnostic analyzer through a scanning device, and acquiring quality control product information or calibrator information through a mode input by a man-machine interaction device or a scanning mode of the scanning device before obtaining the identity of the target quality control calibration frame; the quality control product information at least comprises identification of a quality control product and a quality control test item, and the calibrator information at least comprises identification of a calibrator and a calibration test item;
receiving a selection signal for selecting the identity of the target quality control calibration frame or the identity of the input target quality control calibration frame through a human-computer interaction device, and determining the quality control product or the target quality control calibration frame in which the calibration product is placed according to the selection signal or the identity;
receiving a selection signal for selecting a sample position identifier or an input sample position identifier through a human-computer interaction device, and determining a target sample position for placing a quality control product or a calibrator according to the selection signal or the sample position identifier;
correlating the identification of the quality control product, the quality control test project, the identification of the target quality control calibration frame and the sample position identification of the target sample position to obtain the quality control setting of the target quality control calibration frame; and correlating the identification of the calibrator, the calibration test item, the identification of the target quality control calibration frame and the sample position identification of the target sample position to obtain the calibration setting of the target quality control calibration frame.
In an embodiment, the processor is further configured to:
before the identity of a target quality control calibration frame is obtained by scanning the target quality control calibration frame entering an in-vitro diagnosis analyzer through a scanning device, receiving an application for quality control test by using the target quality control calibration frame through a human-computer interaction device, associating the identity of the target quality control calibration frame with the quality control test application, and setting different quality control products at different target sample positions and corresponding to the associated quality control test items; receiving an application for performing calibration test by using the target quality control calibration frame, associating the identity of the target quality control calibration frame with the calibration test application, and setting different calibration products at different target sample positions and corresponding to the associated calibration test items; the test type associated with the same identity is unique.
In an embodiment, the processor is further configured to: and after the quality control test is finished, the association between the identification mark of the target quality control calibration frame and the quality control test application is released, and after the calibration test is finished, the association between the identification mark of the target quality control calibration frame and the calibration test application is released.
An embodiment provides a computer readable storage medium comprising a program executable by a processor to implement a method as described above.
According to the in-vitro diagnosis analyzer and the method for improving the use efficiency of the sample rack, the identity of the target quality control calibration rack is obtained by scanning the target quality control calibration rack entering the in-vitro diagnosis analyzer; the identity of the target quality control calibration frame is associated with preset quality control settings and calibration settings; acquiring an associated quality control test application or a calibration test application according to the identity of the target quality control calibration frame; when a quality control test application is associated, enabling the associated quality control setting of the target quality control calibration frame to perform corresponding quality control test according to the identity of the target quality control calibration frame; when a calibration test application is associated, enabling the associated calibration setting of the target quality control calibration frame according to the identity of the target quality control calibration frame to perform a corresponding calibration test. Therefore, the quality control calibration frame can be used for both quality control test and calibration test, multiplexing of the sample frame is realized, and the use efficiency of the sample frame is improved.
Drawings
FIG. 1 is a block diagram of an in vitro diagnostic analyzer according to an embodiment of the present invention;
FIG. 2 is a block diagram of an in vitro diagnostic analyzer according to an embodiment of the present invention;
FIG. 3 is a flowchart of a method for improving the efficiency of sample rack use according to an embodiment of the present invention;
fig. 4 is a schematic diagram of a quality control calibration frame in an in vitro diagnostic analyzer according to an embodiment of the invention.
Detailed Description
The invention will be described in further detail below with reference to the drawings by means of specific embodiments. Wherein like elements in different embodiments are numbered alike in association. In the following embodiments, numerous specific details are set forth in order to provide a better understanding of the present application. However, one skilled in the art will readily recognize that some of the features may be omitted, or replaced by other elements, materials, or methods in different situations. In some instances, some operations associated with the present application have not been shown or described in the specification to avoid obscuring the core portions of the present application, and may not be necessary for a person skilled in the art to describe in detail the relevant operations based on the description herein and the general knowledge of one skilled in the art.
Furthermore, the described features, operations, or characteristics of the description may be combined in any suitable manner in various embodiments. Also, various steps or acts in the method descriptions may be interchanged or modified in a manner apparent to those of ordinary skill in the art. Thus, the various orders in the description and drawings are for clarity of description of only certain embodiments, and are not meant to be required orders unless otherwise indicated.
The numbering of the components itself, e.g. "first", "second", etc., is used herein merely to distinguish between the described objects and does not have any sequential or technical meaning. The terms "coupled" and "connected," as used herein, are intended to encompass both direct and indirect coupling (coupling), unless otherwise indicated.
The terms used in this application are defined as follows:
sample: body fluids to be analyzed, such as serum, plasma, urine, cerebrospinal fluid, amniotic fluid or the like.
Sample rack: the carrier for placing the test tube is suitable for an in-vitro diagnosis analyzer for rack type sample injection.
Frame type sample in vitro diagnosis analyzer: the test tube is dispatched to a sample loading port (sample sucking position) of the analyzer through a sample rack, and the sample analyzing device can be a biochemical analyzer or an immune analyzer.
Calibration material: a fluid for analysis on an analyzer, and parameters of the batch of reagents are obtained from the data of the analysis, and are used to calculate test results for a patient sample when the patient sample is tested.
Quality control product: a liquid that can be analyzed on an analyzer, and the quality of the analyzer reagent system is monitored from the data obtained from the analysis for runaway.
Sample position: the sample rack is provided with a sample loading position.
In the embodiment of the invention, the sample rack is associated with the quality control setting and the calibration setting, and different settings are started according to different test applications of operators, so that only one type of sample rack is needed for quality control test and calibration test, the number of sample racks is saved, and the use efficiency of the sample racks is improved. Specific examples are described further below.
As shown in fig. 1, the in-vitro diagnostic analyzer provided in this embodiment adopts a sample rack for sample injection, and is used for analyzing a sample to be tested, and includes: the device comprises a scanning device 10, a processor 20, a man-machine interaction device 30, a testing device 40 and a memory 50.
The scanning device 10 is used for scanning a sample rack entering an in-vitro diagnostic analyzer and a test tube carried by the sample rack to obtain an identity of the sample rack and an identity of the test tube. Samples are typically placed in test tubes, which are often inconvenient to transport directly, so that a sample rack is required for carrying the samples, i.e. transport of the samples is effected by the sample rack. Each sample rack has a unique identity, for example, a sample rack bar code is used as the identity of the sample rack. The identity of the test tube may be a sample barcode. The sample rack may carry one or more samples, and this embodiment is described by taking a sample rack having a plurality of sample positions as an example, and the scanning device 10 may further obtain each sample position on the sample rack by scanning the sample rack. The sample frame is provided with a two-dimensional code, a bar code or a radio frequency label and the like, and the identity and the sample position of the sample frame are obtained by scanning the sample frame, so that the sample frame and a sample thereof can be identified.
Referring to fig. 2, the testing device 40 is configured to test the sample in the sample rack a and output a detection result, for example, to the processor 20 or stored in the memory 50. In the embodiment of the present invention, the testing device 40 may be used for performing an immunoassay to detect an antigen and an antibody in a sample, and the corresponding in vitro diagnostic analyzer is an immunoassay analyzer; the biochemical analysis can also be carried out, various substance components in the sample can be detected, and the corresponding in-vitro diagnostic analyzer is a biochemical analyzer. Depending on the purpose of the analysis, the components of the test device 40 and the detection process may vary, and for example, a biochemical analyzer, the test device 40 generally includes a sampling mechanism (or referred to as a sample dispensing mechanism) 420, a reagent tray 430, a reaction tray 440, a measuring device 410, and a reagent collecting mechanism (or referred to as a reagent dispensing mechanism) 460. A test rail 450 is typically provided at the front end (i.e., near the side of the operator) or the rear end (i.e., the back of the instrument) of the test device 40, a sample sucking position 451 is designed on the test rail 450, and the sampling mechanism 420 is used to suck the sample to be tested from the sample rack a located at the sample sucking position 451 and add the sucked sample to the reaction container 441 placed in the reaction tray 440. The reagent collection mechanism 460 is used to draw reagent from the reagent tray 430 and add the reagent to the corresponding reaction vessel 441 such that the sample and reagent react in the reaction vessel 441. The sampling mechanism 420 and the reagent collection mechanism 460 may be different mechanisms or the same mechanism. The measurement device 410 is used to measure the reacted sample, thereby obtaining a detection result. In other embodiments, the testing device 40 may also be a chemiluminescent instrument, which also includes a magnetic separation disc, although this is not repeated.
The memory 50 is used to hold various test data, analysis results, and/or programs.
The man-machine interaction device 30 is used as an interaction interface between the analyzer and the operator, and is used for receiving information input by the operator and outputting the information in an acoustic, optical or electrical mode. For example, a touch screen can be used, which can not only receive instructions input by an operator, but also display visual information; a mouse, a keyboard, a track ball, a joystick, etc. may be used as an input device of the man-machine interaction device 30 to receive an instruction input by an operator, and a display may be used as a display device of the man-machine interaction device 30 to display visual information. The display displays the analysis result and/or prompt information obtained by the processor 20 or information such as detection progress to an operator in a visual mode.
In this embodiment, the sample rack includes a quality control calibration rack for quality control testing and calibration testing, a conventional rack for conventional testing, and an emergency rack for emergency testing. In the in-vitro diagnostic analyzer, the identity of the target quality control calibration frame is associated with preset quality control settings and calibration settings, for example, the memory 50 stores the quality control settings and calibration settings associated with the identity of the target quality control calibration frame.
The processor 20 is used for scanning the target quality control calibration frame entering the in-vitro diagnosis analyzer through the scanning device 10 to obtain the identity of the target quality control calibration frame; acquiring an associated quality control test application or a calibration test application according to the identity of the target quality control calibration frame; when a quality control test application is associated, enabling the associated quality control setting of the target quality control calibration frame to perform corresponding quality control test according to the identity of the target quality control calibration frame; when a calibration test application is associated, enabling the associated calibration setting of the target quality control calibration frame according to the identity of the target quality control calibration frame to perform a corresponding calibration test. Wherein, the quality control setting includes: the target quality control calibration frame is used as a target sample position for quality control test and a quality control test item which needs to be executed by the target sample position; the calibration settings include: the target quality control calibration frame is used as a target sample position for calibration test and a quality control test item to be executed by the target sample position. For example, by presetting quality control settings and calibration settings, an operator only needs to put a test tube loaded with a corresponding quality control product on a target quality control calibration frame when performing quality control test, and sends a quality control test application through the man-machine interaction device 30; similarly, when the calibration test is performed, only the test tube loaded with the corresponding calibrator is placed on the target quality control calibration frame, and the calibration test application is sent out through the man-machine interaction device 30, so that the multiplexing that one sample frame can be used for both the quality control test and the calibration test is realized, and the use efficiency of the sample frame is improved. Since the quality control test is usually performed after the analyzer is started every day, and the calibration test is usually performed after a new batch of reagents is replaced, and the quality control and the calibration test are staggered in time, the quality control and the calibration test are performed by adopting the sample rack, and therefore, confusion is avoided.
Fig. 3 shows the whole process from the setting of the quality control setting and the calibration setting to the completion of the quality control test or the calibration test, that is, the processor 20 may also implement the method for improving the use efficiency of the sample rack provided by the embodiment of the present invention, which specifically includes the following steps:
step 1, at a quality control setting interface or a calibration setting interface, a processor 20 acquires quality control product information or calibrator information; the quality control product information at least comprises the identification of the quality control product and a quality control test item, and the calibrator information at least comprises the identification of the calibrator and the calibration test item. The quality control information and the calibration material information can be obtained through the input mode of the man-machine interaction device 30, and can also be obtained through the scanning mode of the scanning device 10. In this embodiment, a calibration test is taken as an example, and an operator uses the scanner 10 to scan a barcode on a new batch of reagents to obtain the names, expiration dates, batches, test items, main curves (curves of concentration and luminescence values), quality control states, calibration states, and the like of the reagents. The new reagent is not calibrated, and the calibration state is 'required to be calibrated'; the new reagent does not pass the quality control test in the same day, and the quality control state is 'quality control required'. At the calibration setup interface, the operator uses the scanning device 10 to scan the barcode on the calibrator corresponding to the reagent, and obtains calibrator information, such as identification of the calibrator, calibration test item, main curve (curve of concentration and luminescence value), etc. In other embodiments, the above operations may also be manually input by the operator through the man-machine interaction device 30, for example, inputting a bar code of a reagent, a bar code of a calibrator, etc., which will not be described in detail.
Step 2, the processor 20 receives a selection signal for selecting the identity of the target quality control calibration frame or the identity of the input target quality control calibration frame through the man-machine interaction device 30, and determines the quality control product or the target quality control calibration frame where the calibration product is placed according to the selection signal or the identity. The calibration setting interface displayed on the display of the man-machine interaction device 30 is provided with an identity of the target quality control calibration frame selected by the operator, or is provided with an input box for the operator to input the identity of the target quality control calibration frame. After the operator selects or inputs the identity of the target quality control calibration frame, the quality control calibration frame corresponding to the identity of the target quality control calibration frame is the target quality control calibration frame, and the quality control calibration frame is adopted for loading the calibration materials.
Step 3, the processor 20 receives a selection signal for selecting a sample position identifier or an input sample position identifier through the man-machine interaction device 30, and determines a target sample position for placing a quality control product or a calibration product according to the selection signal or the sample position identifier. The sample bit identifiers are typically numbers, for example 10 sample bits on a sample rack, typically 1-10 Arabic numbers.
Step 4, the processor 20 correlates the identification of the quality control product, the quality control test item, the identification of the target quality control calibration frame, and the sample position identification of the target sample position, so as to obtain the quality control setting of the target quality control calibration frame and store the quality control setting in the memory 50; and correlating the identification of the calibration standard, the calibration test item, the identification of the target quality control calibration frame and the sample position identification of the target sample position to obtain the calibration setting of the target quality control calibration frame and storing the calibration setting in the memory 50. Since the calibration test is taken as an example in this embodiment, the test item of the calibration standard, the identity of the target quality control calibration frame, and the sample position identifier of the target sample position are all set, and the calibration setting of the target quality control calibration frame is obtained by associating and storing the test item, the identity identifier and the sample position identifier of the target sample position by the processor 20, the operator can repeat steps 1 to 4, and the quality control setting is performed in the same manner, which is not repeated in this embodiment. The above-mentioned association is stored in the memory 50, so that the operator does not need to repeatedly set up later, in other words, the operator needs to complete steps 1-8 when using the quality control calibration frame for calibration test for the first time, and the operator only needs to complete steps 5-8 when using the quality control calibration frame for calibration test for the second time and later, so that the operation is very convenient. The operator can also set physical identifiers of test items of the calibration standards on each sample position of the target quality control calibration frame, and as the sample frame multiplexes the quality control products and the calibration standards, the two sides of the sample position can be respectively set with the physical identifiers of the test items of the calibration standards and the physical identifiers of the test items of the quality control products. Of course, the operator can also modify, cancel, and newly build the calibration settings, the quality control settings, etc. in the form of input instructions. In other embodiments, the calibration settings, quality control settings may also be system default, pre-stored in memory 50.
In step 5, at the quality control test application interface of the man-machine interaction device 30, the processor 20 receives an application for performing quality control test by using the target quality control calibration frame through the man-machine interaction device 30, associates the identity of the target quality control calibration frame with the quality control test application, and sets different quality control products at different target sample positions and corresponding to the associated quality control test items. At the calibration test application interface of the man-machine interaction device 30, the processor 20 receives an application for performing calibration test by using the target quality control calibration frame through the man-machine interaction device 30, associates the identity of the target quality control calibration frame with the calibration test application, and sets different calibration products at different target sample positions and corresponding to the associated calibration test items. The test types associated with the identity marks of the same target quality control calibration frame are unique, namely the identity marks of the same target quality control calibration frame are not associated with test applications, are associated with quality control test applications, are associated with calibration test applications, cannot be associated with two test applications at the same time, and are beneficial to fool proofing. In this embodiment, an operator places a calibrator required for calibration test in a test tube corresponding to a target sample position of a target quality control calibration frame, and places the target quality control calibration frame in a sample injection area. An operator issues an application of using the target quality control calibration frame to perform calibration test through the man-machine interaction device 30, the processor 20 displays the identity of the target quality control calibration frame and the related calibrator identity, calibration test items, sample position identity of target sample positions and the like on a calibration test application interface through the man-machine interaction device 30 for checking by the operator, and after receiving an instruction for starting the calibration test through the man-machine interaction device 30, the analyzer sample injection is started.
And 6, the processor 20 scans the target quality control calibration frame entering the in-vitro diagnosis analyzer through the scanning device 10 to obtain the identity of the target quality control calibration frame.
Existing quality control rack bar codes are usually started with C, and calibration rack bar codes are usually started with S; in the quality control calibration frame of the present invention, taking the schematic diagram in fig. 4 as an example, the bar code A1 may be in the form of a sign number+number, such as SC, followed by a plurality of numbers (shown as xxx in the figure). The circles in fig. 4 represent sample bits, 10 sample bits in the figure, and 1-10 can be used as sample bit identifiers for 10 sample bits. Each sample position can correspond to a quality control product QC1 and a calibrator C1, the quality control calibration frame is more convenient to use by matching with a physical identifier, and an operator can see what quality control product and what calibrator are placed on the sample position at a glance.
Step 7, the processor 20 obtains an associated quality control test application or calibration test application according to the identity of the target quality control calibration frame, and in this embodiment, the calibration test application is obtained.
Step 8, when the identity of the target quality control calibration frame is associated with a quality control test application, the processor 20 starts the associated quality control setting according to the identity of the target quality control calibration frame to perform a corresponding quality control test; when a calibration test application is associated, enabling the associated calibration setting of the target quality control calibration frame according to the identity of the target quality control calibration frame to perform a corresponding calibration test. This embodiment is associated with a calibration test application, so that after the target quality control calibration frame enters the sample suction site 451, the processor 20 sucks the calibrator through the sampling mechanism 420 and adds the sucked calibrator to the reaction vessel 441 placed in the reaction tray 440. The processor 20 sucks the reagent from the reagent tray 430 through the reagent collecting mechanism 460 and adds the reagent to the corresponding reaction vessel 441 so that the calibrator and the reagent react in the reaction vessel 441. The processor 20 measures the reacted sample by the measuring device 410 to obtain a detection result, and the processor 20 analyzes the detection result to obtain a result of the calibration test to complete the calibration test.
After step 8, the processor 20 is further configured to disassociate the identity of the target quality control calibration frame from the quality control test application after the quality control test is completed, disassociate the identity of the target quality control calibration frame from the calibration test application after the calibration test is completed, and facilitate further test applications.
In summary, the in-vitro diagnostic analyzer and the method for improving the use efficiency of the sample rack provided by the invention enable the quality control test and the calibration test to use the same sample rack, realize the multiplexing of the sample rack and improve the use efficiency of the sample rack.
Reference is made to various exemplary embodiments herein. However, those skilled in the art will recognize that changes and modifications may be made to the exemplary embodiments without departing from the scope herein. For example, the various operational steps and components used to perform the operational steps may be implemented in different ways (e.g., one or more steps may be deleted, modified, or combined into other steps) depending on the particular application or taking into account any number of cost functions associated with the operation of the system.
Additionally, as will be appreciated by one of skill in the art, the principles herein may be reflected in a computer program product on a computer readable storage medium preloaded with computer readable program code. Any tangible, non-transitory computer readable storage medium may be used, including magnetic storage devices (hard disks, floppy disks, etc.), optical storage devices (CD-ROMs, DVDs, blu-Ray disks, etc.), flash memory, and/or the like. These computer program instructions may be loaded onto a general purpose computer, special purpose computer, or other programmable data processing apparatus to produce a machine, such that the instructions which execute on the computer or other programmable data processing apparatus create means for implementing the functions specified. These computer program instructions may also be stored in a computer-readable memory that can direct a computer or other programmable data processing apparatus to function in a particular manner, such that the instructions stored in the computer-readable memory produce an article of manufacture including means which implement the function specified. The computer program instructions may also be loaded onto a computer or other programmable data processing apparatus to cause a series of operational steps to be performed on the computer or other programmable apparatus to produce a computer implemented process such that the instructions which execute on the computer or other programmable apparatus provide steps for implementing the functions specified.
While the principles herein have been shown in various embodiments, many modifications of structure, arrangement, proportions, elements, materials, and components, which are particularly adapted to specific environments and operative requirements, may be used without departing from the principles and scope of the present disclosure. The above modifications and other changes or modifications are intended to be included within the scope of this document.
The foregoing detailed description has been described with reference to various embodiments. However, those skilled in the art will recognize that various modifications and changes may be made without departing from the scope of the present disclosure. Accordingly, the present disclosure is to be considered as illustrative and not restrictive in character, and all such modifications are intended to be included within the scope thereof. Also, advantages, other advantages, and solutions to problems have been described above with regard to various embodiments. The benefits, advantages, solutions to problems, and any element(s) that may cause any benefit, advantage, or solution to occur or become more pronounced are not to be construed as a critical, required, or essential feature. The terms "comprises," "comprising," or any other variation thereof, are intended to cover a non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements does not include only those elements but may include other elements not expressly listed or inherent to such process, method, system, article, or apparatus. Furthermore, the term "couple" and any other variants thereof are used herein to refer to physical connections, electrical connections, magnetic connections, optical connections, communication connections, functional connections, and/or any other connection.
Those skilled in the art will recognize that many changes may be made to the details of the above-described embodiments without departing from the underlying principles of the invention. Accordingly, the scope of the invention should be determined from the following claims.
Claims (7)
1. A method for improving the efficiency of use of a sample rack, comprising the steps of:
scanning a target quality control calibration frame entering the in-vitro diagnostic analyzer to obtain an identity of the target quality control calibration frame; the sample rack of the in-vitro diagnostic analyzer comprises a quality control calibration rack for quality control test and calibration test; the identity of the target quality control calibration frame is associated with preset quality control settings and calibration settings; the quality control arrangement comprises: the target quality control calibration frame is used as a target sample position for quality control test and a test item to be executed for the target sample position; the calibration settings include: the target quality control calibration frame is used for calibrating target sample positions of the test and test items to be executed on the target sample positions;
acquiring an associated quality control test application or a calibration test application according to the identity of the target quality control calibration frame;
when a quality control test application is associated, enabling the associated quality control setting of the target quality control calibration frame to carry out corresponding quality control test according to the identity of the target quality control calibration frame, and releasing the association between the identity of the target quality control calibration frame and the quality control test application after the quality control test is finished; when a calibration test application is associated, enabling the associated calibration setting according to the identification of the target quality control calibration frame to perform a corresponding calibration test, and releasing the association between the identification of the target quality control calibration frame and the calibration test application after the calibration test is finished.
2. The method of claim 1, wherein scanning the target quality control calibration frame entered into the in vitro diagnostic analyzer comprises, prior to obtaining an identity of the target quality control calibration frame:
acquiring quality control product information or calibrator information in an input or scanning mode; the quality control product information at least comprises identification of a quality control product and a quality control test item, and the calibrator information at least comprises identification of a calibrator and a calibration test item;
receiving a selection signal for selecting the identity of a target quality control calibration frame or the identity of the input target quality control calibration frame, and determining the quality control product or the target quality control calibration frame in which the calibration product is placed according to the selection signal or the identity;
receiving a selection signal or an input sample bit identifier for selecting the sample bit identifier, and determining a target sample bit for placing a quality control product or a calibrator according to the selection signal or the sample bit identifier;
correlating the identification of the quality control product, the quality control test project, the identification of the target quality control calibration frame and the sample position identification of the target sample position to obtain the quality control setting of the target quality control calibration frame; and correlating the identification of the calibrator, the calibration test item, the identification of the target quality control calibration frame and the sample position identification of the target sample position to obtain the calibration setting of the target quality control calibration frame.
3. The method of claim 2, wherein scanning the target quality control calibration frame into the in vitro diagnostic analyzer, before obtaining the identity of the target quality control calibration frame, further comprises:
receiving an application of performing quality control test by using the target quality control calibration frame, associating the identity of the target quality control calibration frame with the quality control test application, and setting different quality control products at different target sample positions and corresponding to the associated quality control test items; receiving an application for performing calibration test by using the target quality control calibration frame, associating the identity of the target quality control calibration frame with the calibration test application, and setting different calibration products at different target sample positions and corresponding to the associated calibration test items; the test type associated with the same identity is unique.
4. An in vitro diagnostic analyzer comprising:
the scanning device is used for scanning the sample rack to obtain the identity mark of the sample rack; the sample rack comprises a quality control calibration rack, wherein the identity of the target quality control calibration rack is associated with preset quality control settings and calibration settings; the quality control arrangement comprises: the target quality control calibration frame is used as a target sample position for quality control test and a test item to be executed for the target sample position; the calibration settings include: the target quality control calibration frame is used for calibrating target sample positions of the test and test items to be executed on the target sample positions;
the testing device is used for testing the samples in the sample rack;
the processor is used for scanning the target quality control calibration frame entering the in-vitro diagnosis analyzer through the scanning device to obtain the identity of the target quality control calibration frame; acquiring an associated quality control test application or a calibration test application according to the identity of the target quality control calibration frame; when a quality control test application is associated, enabling the associated quality control setting of the target quality control calibration frame to carry out corresponding quality control test according to the identity of the target quality control calibration frame, and releasing the association between the identity of the target quality control calibration frame and the quality control test application after the quality control test is finished; when a calibration test application is associated, enabling the associated calibration setting according to the identification of the target quality control calibration frame to perform a corresponding calibration test, and releasing the association between the identification of the target quality control calibration frame and the calibration test application after the calibration test is finished.
5. The in-vitro diagnostic analyzer of claim 4 further comprising human-machine interaction means for receiving operator input and output visual information; the processor is further configured to:
scanning a target quality control calibration frame entering the in-vitro diagnostic analyzer through a scanning device, and acquiring quality control product information or calibrator information through a mode input by a man-machine interaction device or a scanning mode of the scanning device before obtaining the identity of the target quality control calibration frame; the quality control product information at least comprises identification of a quality control product and a quality control test item, and the calibrator information at least comprises identification of a calibrator and a calibration test item;
receiving a selection signal for selecting the identity of the target quality control calibration frame or the identity of the input target quality control calibration frame through a human-computer interaction device, and determining the quality control product or the target quality control calibration frame in which the calibration product is placed according to the selection signal or the identity;
receiving a selection signal for selecting a sample position identifier or an input sample position identifier through a human-computer interaction device, and determining a target sample position for placing a quality control product or a calibrator according to the selection signal or the sample position identifier;
correlating the identification of the quality control product, the quality control test project, the identification of the target quality control calibration frame and the sample position identification of the target sample position to obtain the quality control setting of the target quality control calibration frame; and correlating the identification of the calibrator, the calibration test item, the identification of the target quality control calibration frame and the sample position identification of the target sample position to obtain the calibration setting of the target quality control calibration frame.
6. The in vitro diagnostic analyzer of claim 5 wherein said processor is further configured to:
before the identity of a target quality control calibration frame is obtained by scanning the target quality control calibration frame entering an in-vitro diagnosis analyzer through a scanning device, receiving an application for quality control test by using the target quality control calibration frame through a human-computer interaction device, associating the identity of the target quality control calibration frame with the quality control test application, and setting different quality control products at different target sample positions and corresponding to the associated quality control test items; receiving an application for performing calibration test by using the target quality control calibration frame, associating the identity of the target quality control calibration frame with the calibration test application, and setting different calibration products at different target sample positions and corresponding to the associated calibration test items; the test type associated with the same identity is unique.
7. A computer readable storage medium comprising a program executable by a processor to implement the method of any one of claims 1-3.
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