CN111265449A

CN111265449A - Isolation protection composition and preparation method thereof

Info

Publication number: CN111265449A
Application number: CN202010239203.1A
Authority: CN
Inventors: 马娟娟
Original assignee: Xi'an Runyu Medical Technology Co Ltd
Current assignee: Xi'an Runyu Medical Technology Co Ltd
Priority date: 2020-03-30
Filing date: 2020-03-30
Publication date: 2020-06-12

Abstract

The invention discloses an isolation protection composition, which consists of the following components: 5-10 parts of silicone oil, 9-12 parts of synthetic grease, 1-2 parts of a film-forming agent, 9-17 parts of powder, 4-6 parts of a silicon elastomer, 2-2.8 parts of a thickening stabilizer, 4-4.5 parts of an emulsifier, 9-12 parts of a humectant, 1.5-4 parts of a plant extract composition, 0.3-0.8 part of vitamin E, 0.2-0.5 part of panthenol, 0.02-0.1 part of astaxanthin, 0.1-0.3 part of bisabolol, 0.8-1.2 parts of an antibacterial agent and the balance of water, wherein the sum of the mass percentages of the components is 100%. The invention provides an isolation protection product which can protect against ultraviolet rays, blue light and air pollution in all directions, is fresh, cool, not greasy, skin-friendly, safe and effective, and can prevent skin problems such as skin aging and sensitivity and keep the skin in a healthy and beautiful state; the preparation method disclosed by the invention is simple to operate, low in cost and high in practical value.

Description

Isolation protection composition and preparation method thereof

Technical Field

The invention belongs to the technical field of cosmetics, and particularly relates to an isolation and protection composition and a preparation method of the isolation and protection composition.

Background

With the development of society and the deepening of scientific research, people have deeply recognized the importance of sun protection on skin health, no matter men and women, old and young can carry out sun protection intentionally, but when the society develops rapidly, the radiation faced by people is not only ultraviolet, and the blue light radiation of electronic products such as mobile phones, computers, televisions and the like also accelerates the aging and sensitivity of skin.

The Pigment Cell Melanoma Res. 2014 study showed: blue light in visible light (415nm) can also induce skin pigmentation, and visible light (blue light) and ultraviolet light have a superimposed effect on the production of pigmentation and erythema. In addition, with the development of industry, air pollution is more serious, and pollutants in the air also seriously affect the health of skin, so that the skin is dull and dull, the elasticity is reduced, and the problems of color spots, wrinkles, sensitivity and the like are caused. The study of J Soeur and the like in 2017 finds that: contaminants in the air can exacerbate ultraviolet-induced oxidative stress of keratinocytes, affecting skin health.

With the recognition of the above problems, the need for protective cosmetics has arisen. The product of the isolation cream in the market is all good in comparison, but the isolation cream can provide the effect of correcting skin color basically, a small part of the isolation cream has the effect of protecting ultraviolet rays, and the isolation cream is mainly prepared from a chemical sun-screening agent and assisted by a physical sun-screening agent, so that the isolation cream is very irritating and difficult to use for most of people with sensitive skin. In recent years, individual haze-proof isolation products appear, but most of the haze-proof isolation products are still isolated by film forming, and a plurality of products with deeper comprehensive adjustment are available. Skin care products for protecting blue light are few, eye patches are mainly used for relieving eye fatigue, and other face creams with anti-oxidation and anti-aging effects are matched. Therefore, a full-effect isolation and protection composition product is developed, the skin color can be corrected while ultraviolet radiation, blue light radiation and haze are isolated, the safety index is high, and the full-effect isolation and protection composition product is suitable for sensitive people.

Disclosure of Invention

The first purpose of the invention is to provide an isolation and protection composition, which solves the problems that the existing isolation and protection products can not isolate ultraviolet radiation and blue light radiation and are not suitable for people with sensitive skin.

A second object of the present invention is to provide a method for preparing a barrier shield composition.

The first technical scheme adopted by the invention is that the isolation protection composition comprises the following components in parts by mass: 5-10 parts of silicone oil, 9-12 parts of synthetic grease, 1-2 parts of a film-forming agent, 9-17 parts of powder, 4-6 parts of a silicon elastomer, 2-2.8 parts of a thickening stabilizer, 4-4.5 parts of an emulsifier, 9-12 parts of a humectant, 1.5-4 parts of a plant extract composition, 0.3-0.8 part of vitamin E, 0.2-0.5 part of panthenol, 0.02-0.1 part of astaxanthin, 0.1-0.3 part of bisabolol, 0.8-1.2 parts of an antibacterial agent and the balance of water, wherein the sum of the mass percentages of the components is 100%;

the silicone oil is selected from at least two of cetyl dimethyl siloxane, polydimethylsiloxane, and phenyl polymethyl siloxane;

the thickening stabilizer is the combination of sodium chloride and any one of alkyl quaternized organic bentonite and distearyl dimethyl ammonium hectorite.

The present invention is also characterized in that,

the synthetic oil is specifically a composition of at least any three of isopropyl isostearate, diethylhexyl carbonate, isononyl isononanoate and caprylic/capric triglyceride;

the film forming agent is the combination of cyclopentadimethyl siloxane, trimethylsiloxy silicate and C24-28 alkyl polymethyl siloxane; the film former may also be an alkyl polyvinylpyrrolidone;

the humectant is selected from at least two of glycerol, 1, 2-pentanediol, 1, 3-propanediol, and 1, 3-butanediol.

The powder is specifically a combination of titanium dioxide, zinc oxide, red iron oxide, black iron oxide and yellow iron oxide, wherein the particle size of the titanium dioxide is 80nm, the mass ratio of the titanium dioxide to the zinc oxide is 3-4:5, and the mass ratio of the red iron oxide, the black iron oxide and the yellow iron oxide is 5:3: 20.

The silicon elastomer is a combination of cyclopentadidimethyl siloxane, polydimethylsiloxane/vinyl polydimethylsiloxane cross-linked polymer and polydimethylsiloxane; the silicone elastomer may also be a polydimethylsiloxane, a combination of polydimethylsiloxane/vinyl polydimethylsiloxane crosspolymers.

The emulsifier is the combination of any two of PEG-9 polydimethylsiloxyethyl polydimethylsiloxane, lauryl PEG-9 polydimethylsiloxyethyl polydimethylsiloxane, cetyl PEG/PPG-10/1 polydimethylsiloxane and polyglycerol-4 isostearate, and the mass ratio of any combination is 1: 2.

The plant extract composition is the combination of at least three of fructus Vitics Simplicifoliae extract, Moringa seed oil, flos Buddlejae extract, glucosyl rutin, and cacao seed extract;

the antibacterial agent is the combination of any two of caprylyl hydroxypentanoic acid, 1, 2-hexanediol and phenoxyethanol.

The second technical scheme adopted by the invention is that the preparation method of the isolation protection composition comprises the following steps:

step 1, weighing raw materials

Weighing the following raw materials in parts by mass: 5-10 parts of silicone oil, 9-12 parts of synthetic grease, 1-2 parts of a film-forming agent, 9-17 parts of powder, 4-6 parts of a silicon elastomer, 2-2.8 parts of a thickening stabilizer, 4-4.5 parts of an emulsifier, 9-12 parts of a humectant, 1.5-4 parts of a plant extract composition, 0.3-0.8 part of vitamin E, 0.2-0.5 part of panthenol, 0.02-0.1 part of astaxanthin, 0.1-0.3 part of bisabolol, 0.8-1.2 parts of an antibacterial agent and the balance of water, wherein the sum of the mass percentages of the components is 100%;

dividing the silicone oil into silicone oil a and silicone oil b, wherein the silicone oil a is any one of silicone oils, and the silicone oil b is the combination of the rest substances;

step 2, mixing the materials

Mixing the synthetic grease, the film-forming agent, the powder and the silicone oil b in the step 1, homogenizing and stirring until uniform, and recording as phase A for later use;

mixing the silicone oil a in the step 1, the thickening stabilizer, the silicon elastomer and the emulsifier, stirring to uniformly disperse the silicon elastomer, and just soaking the thickening stabilizer to be recorded as a phase B for later use;

mixing water, humectant and sodium chloride in the thickening stabilizer, and stirring to completely dissolve the sodium chloride to obtain phase C for later use;

step 3, mixing the materials

Mixing the phase A and the phase B in the step 2, homogenizing, stirring and heating, and heating the phase C to the same temperature;

step 4, emulsification

Adding the phase C treated in the step 3 into the mixture of the phase A and the phase B treated in the step 3 for 5 times, wherein the interval is 5-8min each time, and sequentially accelerating stirring while adding to obtain a premix;

step 5, cooling the premix in air to be not higher than 40 ℃, sequentially adding the plant extract composition, the vitamin E, the panthenol, the astaxanthin, the bisabolol and the antibacterial agent in the step 1, stirring for 10min uniformly, and then continuing stirring for 5-8min at the rotating speed of 6000-7000 rpm;

and 6, detecting the pre-mixture treated in the step 5 to be qualified, thus obtaining the required composition.

The present invention is also characterized in that,

in step 2, the homogenizing and stirring conditions of the phase A are as follows: the rotation speed is 5000-.

Heating to 50 +/-2 ℃ in the step 3;

the parameters of homogenizing and stirring in the step 3 are as follows: the rotation speed is 5000-.

The stirring conditions in the step 4 are as follows: stirring at a rotating speed until the mixed raw materials can be completely rolled, and stirring time is not less than 10min after the last addition.

The detection standard in the step 6 is that the following three points are met:

a. standing the pre-mixture treated in the step 5 at room temperature for not less than 24h, centrifuging at the speed of 2000r/min for 30min, and then not layering;

b. keeping the temperature of the pre-mixture treated in the step 5 at 40 +/-1 ℃ for 24 hours, and recovering the room temperature without layering;

c. keeping the temperature of the pre-mixture treated in the step 5 at minus 8 +/-2 ℃ for 24 hours, and ensuring that no layering phenomenon exists after the room temperature is recovered.

The invention has the beneficial effects that: the invention relates to an isolation and protection composition, which combines the factors influencing the health of skin from three angles of ultraviolet resistance, electronic product resistance, blue light in visible light and air pollution resistance, takes the isolation and protection effect and the use safety into full consideration according to the self characteristics of sensitive skin and the product adaptability, simultaneously takes the use comfort of the product into consideration, provides a fresh, non-greasy, skin-friendly, safe and effective isolation and protection product, delays the skin aging, sensitivity and other skin problems, and keeps the skin in a healthy and beautiful state; the preparation method disclosed by the invention is simple to operate, low in cost and high in practical value.

Drawings

FIG. 1 is a bar graph of human trial scores in the trial evaluation of sensitive skin for an isolation barrier composition of the present invention;

FIG. 2 is a bar graph of the average human body sample score in the trial evaluation of sensitive skin for the barrier shield composition of the present invention;

FIG. 3 is a bar graph of the effectiveness of the barrier shield composition of the present invention on human use in evaluating human effectiveness.

Detailed Description

The present invention will be described in detail below with reference to the accompanying drawings and specific embodiments.

The invention relates to an isolation protection composition which comprises the following components in parts by mass: 5-10 parts of silicone oil, 9-12 parts of synthetic grease, 1-2 parts of a film-forming agent, 9-17 parts of powder, 4-6 parts of a silicon elastomer, 2-2.8 parts of a thickening stabilizer, 4-4.5 parts of an emulsifier, 9-12 parts of a humectant, 1.5-4 parts of a plant extract composition, 0.3-0.8 part of vitamin E, 0.2-0.5 part of panthenol, 0.02-0.1 part of astaxanthin, 0.1-0.3 part of bisabolol, 0.8-1.2 parts of an antibacterial agent and the balance of water, wherein the sum of the mass percentages of the components is 100%.

Of the above components, water is present as a solvent for the composition of the present invention.

The silicone oil is a combination of at least two of cetyl dimethyl siloxane, polydimethylsiloxane and phenyl polymethyl siloxane, and is used as a powder dispersing agent and an emollient and can provide refreshing and easily-pushed skin feeling.

The synthetic oil is a composition of at least three of isopropyl isostearate, diethylhexyl carbonate, isononyl isononanoate and caprylic/capric triglyceride, and is added to serve as a powder dispersant and an emollient.

The film forming agent is specifically the combination of cyclopentadimethyl siloxane, trimethylsiloxy silicate and C24-28 alkyl polymethyl siloxane, or the film forming agent is alkyl polyvinylpyrrolidone; all play a role in film formation.

The powder is specifically a combination of titanium dioxide (80nm), zinc oxide, red iron oxide, black iron oxide and yellow iron oxide, wherein the mass ratio of the titanium dioxide to the zinc oxide is 3-4:5, and the mass ratio of the red iron oxide to the black iron oxide to the yellow iron oxide is 5:3: 20; the powder is a reflecting agent of ultraviolet rays and blue light, can isolate the damage of the ultraviolet rays and the blue light to the skin, and can correct the skin color and isolate the blemish.

The silicon elastomer is specifically a combination of cyclopentadidimethyl siloxane, polydimethylsiloxane/vinyl polydimethylsiloxane cross-linked polymer and polydimethylsiloxane, and the silicon elastomer can also be a combination of polydimethylsiloxane, polydimethylsiloxane/vinyl polydimethylsiloxane cross-linked polymer; its effect is to provide a fresh and good skin feel.

The thickening stabilizer is the combination of any one of alkyl quaternized organic bentonite and distearyl dimethyl ammonium hectorite and sodium chloride, and plays a role in stabilizing the whole system, so that the composition cannot have the problems of layering, oil and water discharge and the like in shelf life.

The emulsifier is the combination of any two of PEG-9 polydimethylsiloxyethyl polydimethylsiloxane, lauryl PEG-9 polydimethylsiloxyethyl polydimethylsiloxane, cetyl PEG/PPG-10/1 polydimethylsiloxane and polyglycerol-4 isostearate, the mass ratio of any two combinations is 1:2, and the emulsifier is used for mixing oil-soluble substances and water-soluble substances together; the emulsifier accounts for more of the main emulsification, and the emulsifier accounts for less of the auxiliary emulsification. For example, PEG-9 polydimethylsiloxyethyl polydimethylsiloxane and lauryl PEG-9 polydimethylsiloxyethyl polydimethylsiloxane in a mass ratio of 1:2 are selected, and the lauryl PEG-9 polydimethylsiloxyethyl polydimethylsiloxane is mainly emulsified; if a mass ratio of 2:1 PEG-9 dimethiconoethyl dimethicone to lauryl PEG-9 dimethiconoethyl dimethicone was chosen, then the dimethiconoethyl dimethicone was the predominant emulsifying agent.

The plant extract composition is the combination of at least three of fructus Vitics Simplicifoliae extract, Moringa seed oil, flos Buddlejae extract, glucosyl rutin, and cacao seed extract; the ultraviolet ray absorbing agent has the advantages that firstly, some wavelengths capable of absorbing ultraviolet rays play a role in sunscreen and synergism, secondly, an anti-oxidation effect of removing free radicals is achieved, the ultraviolet rays, blue light and haze are prevented from damaging skin, thirdly, an anti-haze effect is achieved, and oxidation reaction caused by haze is prevented.

The vitamin E can prevent the substances of the composition from being oxidized on one hand, maintain the stability of the system, and can resist oxidation and remove free radicals initiated by haze, ultraviolet rays and blue light on the other hand.

Panthenol has the main effects of moisturizing, promoting skin repair and strengthening the skin barrier.

Astaxanthin can absorb ultraviolet ray on the one hand and play sun-proof synergism's effect, and on the other hand can be anti-oxidant, clear away the free radical that haze, ultraviolet ray and blue light initiate.

The bisabolol has antiinflammatory and antiallergic effects.

The antibacterial agent is the combination of any two of caprylyl hydroxypentanoic acid, 1, 2-hexanediol and phenoxyethanol, and has the function of preventing the composition from being infected with bacteria.

The invention relates to a preparation method of an isolation protection composition, which specifically comprises the following steps:

step 1, weighing raw materials

dividing the silicone oil in the step 1 into silicone oil a and silicone oil b, wherein the silicone oil a is any one of the silicone oils, and the silicone oil b is the combination of the rest substances;

step 2, mixing the materials

Mixing the synthetic grease, the film-forming agent, the powder and the silicon oil b in the step 1, and homogenizing and stirring for 2-3min at the rotation speed of 5000-; the stirring aims to uniformly disperse the powder without coarse particles;

step 3, mixing the materials

Mixing the phase A and the phase B in the step 2, homogenizing, stirring and heating, and heating the phase C to the same temperature of 50 +/-2 ℃;

the parameters of the homogenizing and stirring are as follows: the rotation speed is 5000-.

Step 4, emulsification

Adding the phase C treated in the step 3 into the mixture of the phase A and the phase B treated in the step 3 for 5 times, wherein the interval is 5-8min each time, and sequentially accelerating stirring while adding to obtain a premix; the stirring conditions were: stirring at a rotating speed until the mixed raw materials can be completely rolled, and stirring time is not less than 10min after the last addition;

step 5, cooling the premix in air to be not higher than 40 ℃, sequentially adding the plant extract composition, the vitamin E, the panthenol, the astaxanthin, the bisabolol and the antibacterial agent in the step 1, stirring for 10min uniformly, and stirring for 5-8min at the rotating speed of 6000-7000 rpm;

step 6, the premixture treated in the step 5 is qualified after detection, and then the required composition is obtained;

the detection criteria are that the following three points are satisfied:

The following examples were carried out using the above method, with specific parameters detailed in table 1:

table 1 the component parameters

Safety and efficacy tests were performed on the barrier shield compositions produced in examples 1-5:

1. evaluation of safety

Number of samples: 30 persons;

the experimental method comprises the following steps: a skin closed patch test is carried out according to the requirements of the skin closed patch test of 2015 version of technical Specification for cosmetic safety;

and (3) judging standard: evaluating the results according to the general rules of diagnosis and treatment of skin diseases of cosmetics (GB 17149-1) and the diagnosis and treatment rules of contact dermatitis of cosmetics (GB 17149-2).

And (4) experimental conclusion: the sample size of 30 people, no skin adverse reaction, shows that the composition of the invention has good safety.

2. Evaluation of stability

Evaluation criteria: the stability evaluation is carried out according to GB/T29665-2013.

(1) And (3) testing heat resistance stability: samples of the compositions of examples 1 to 5 were taken, and kept in a constant temperature incubator at 40 ℃ for 24 hours, and then returned to room temperature, and observed;

the appearance of the sample is observed to be unchanged compared with that before treatment, and the delamination phenomenon does not occur.

(2) And (3) testing cold stability: samples of the compositions of examples 1 to 5 were taken, respectively, and kept in a refrigerator at-8 ℃ for 24 hours, and after returning to room temperature, the phenomenon was observed;

(3) And (3) centrifugal test: taking a proper amount of the compositions of the embodiments 1 to 5 respectively, putting the compositions into a centrifuge tube, centrifuging the compositions for 30min at the rotating speed of 2000r/min, and observing the phenomenon;

In conclusion, the composition prepared by the invention has good stability, all components are uniformly dispersed, and the layering phenomenon is not easy to occur.

3. Trial evaluation of sensitive skin

Experimental samples: 50 volunteers who had sensitive skin or had undergone medical and non-invasive surgery recently (within 7 days) were all women;

the experimental method comprises the following steps: the composition is administered to 50 people every morning for 30 days;

and (4) judging the standard: the fraction is more than or equal to 0 and less than 6, which is unacceptable; the fraction is more than or equal to 6 and less than 8; the fraction is more than or equal to 8 and less than 9; the fraction of 9-10 is very satisfactory and no adverse reaction occurs;

and (4) experimental conclusion: the composition has no adverse reaction and good safety when being used for sensitive skin tests, as shown in figure 2, the average test feeling of 50 volunteers is more than 8.7, the whole is satisfactory, all scores are concentrated in 7-10, as shown in figure 1 (wherein the abscissa is the score, the ordinate is the percentage of each score, and the number of people appearing in each score is divided by the total number of people), and the number of 9 scores is the largest, so that the composition has good use feeling, and has the effects of resisting senility and brightening skin color after being used for a long time.

4. Evaluation of human body effectiveness

Experimental samples: 20 volunteers;

the experimental method comprises the following steps: the test time is 11-12 months with concentrated haze and the place is Sichuan, and the test time is equal to the number of days when the test device is exposed to blue light (a panel, a mobile phone and a computer) for at least 4 hours on average, and sun-proof tools such as sun-proof cream, sunshade and the like are not used;

the test method is a double-blind test, and the composition is smeared on the left half face of the morning by 2mg/cm²The right half face is coated with the isolation cream with the effect of concealing the flaws on the market for 8 weeks continuously, and the volunteers self-rate the conditions of the left face and the right face;

and (4) experimental conclusion: as shown in figure 3, the left face of the volunteer is superior to the right face of the volunteer in parameters such as skin color brightness, wrinkles, elasticity, fineness and smoothness, and the isolation and protection composition of the invention is proved to be capable of effectively isolating the damage of ultraviolet rays, blue light and haze to the skin and protecting the skin.

Claims

1. An isolation protection composition is characterized by comprising the following components in parts by mass: 5-10 parts of silicone oil, 9-12 parts of synthetic grease, 1-2 parts of a film-forming agent, 9-17 parts of powder, 4-6 parts of a silicon elastomer, 2-2.8 parts of a thickening stabilizer, 4-4.5 parts of an emulsifier, 9-12 parts of a humectant, 1.5-4 parts of a plant extract composition, 0.3-0.8 part of vitamin E, 0.2-0.5 part of panthenol, 0.02-0.1 part of astaxanthin, 0.1-0.3 part of bisabolol, 0.8-1.2 parts of an antibacterial agent and the balance of water, wherein the sum of the mass percentages of the components is 100%;

the silicone oil is specifically a combination of at least two of cetyl dimethyl siloxane, polydimethylsiloxane and phenyl polymethyl siloxane;

the thickening stabilizer is specifically a combination of sodium chloride and any one of alkyl quaternized organic bentonite and distearyl dimethyl ammonium hectorite.

2. A barrier shield composition according to claim 1, wherein said synthetic oil is a combination of not less than any three of isopropyl isostearate, diethylhexyl carbonate, isononyl isononanoate, caprylic/capric triglyceride;

the film forming agent is specifically the combination of cyclopentadimethyl siloxane, trimethylsiloxy silicate and C24-28 alkyl polymethyl siloxane; the film former may also be an alkyl polyvinylpyrrolidone;

the humectant is a combination of at least two of glycerol, 1, 2-pentanediol, 1, 3-propanediol and 1, 3-butanediol.

3. The isolation protection composition as claimed in claim 1, wherein the powder is a combination of titanium dioxide, zinc oxide, red iron oxide, black iron oxide and yellow iron oxide, wherein the particle size of the titanium dioxide is 80nm, the mass ratio of the titanium dioxide to the zinc oxide is 3-4:5, and the mass ratio of the red iron oxide, the black iron oxide and the yellow iron oxide is 5:3: 20.

4. A barrier shield composition according to claim 1, wherein said silicone elastomer is selected from the group consisting of cyclopentadimethicone, dimethicone/vinyl dimethicone crosspolymer, dimethicone; the silicone elastomer may also be a polydimethylsiloxane, a combination of polydimethylsiloxane/vinyl polydimethylsiloxane crosspolymers.

5. The barrier shield composition according to claim 1, wherein the emulsifier is a combination of any two of PEG-9 polydimethylsiloxyethyl dimethicone, lauryl PEG-9 polydimethylsiloxyethyl dimethicone, cetyl PEG/PPG-10/1 dimethicone, and polyglyceryl-4 isostearate, and the mass ratio of any two combinations is 1: 2.

6. The barrier protection composition as claimed in claim 1, wherein the plant extract composition is a combination of at least any three of a vitex rotundifolia fruit extract, moringa seed oil, a buddleja officinalis flower extract, glucosylrutin, and a cocoa seed extract;

the antibacterial agent is a combination of any two of caprylyl hydroxypentanoic acid, 1, 2-hexanediol and phenoxyethanol.

7. A process for preparing a barrier shield composition according to any one of claims 1 to 6, comprising the steps of:

step 1, weighing raw materials

step 2, mixing the materials

step 3, mixing the materials

step 4, emulsification

8. The method of claim 1, wherein in step 2, the phase A is homogenized under the following conditions: the rotation speed is 5000-.

9. The method of claim 1, wherein the heating in step 3 is performed to a temperature of 50 ± 2 ℃;

10. The method of claim 1, wherein the criteria measured in step 6 are the following three points: