CN111202822A

CN111202822A - Gynecological external antibacterial spray and preparation method thereof

Info

Publication number: CN111202822A
Application number: CN202010228975.5A
Authority: CN
Inventors: 于秀华; 韦安迪
Original assignee: Shandong Chuanyun Biotechnology Co Ltd
Current assignee: Shandong Chuanyun Biotechnology Co Ltd
Priority date: 2020-03-27
Filing date: 2020-03-27
Publication date: 2020-05-29

Abstract

The invention relates to the technical field of daily replacement products for female health, in particular to a gynecological external antibacterial spray and a preparation method thereof. The gynecological external antibacterial composition at least comprises the following components in parts by weight: 0.01-0.3 part of borneol, 0.01-0.1 part of lactobacillus fermentation product, 0.1-3 parts of radix sophorae flavescentis extract, 0.1-2 parts of cortex phellodendri extract, 0.01-0.2 part of radix stemonae extract, 0.1-2 parts of fructus cnidii extract, 0.1-0.5 part of shaddock seed extract and 0.05-0.5 part of ecological nutrient solution. The gynecological external antibacterial spray provided by the invention contains the antibacterial composition, can effectively inhibit various bacteria such as staphylococcus aureus, candida albicans, escherichia coli and the like, and has a remarkable sterilizing effect; the application method is simple and convenient, only a proper amount of medicine is needed to be directly sprayed into the vagina, and the liquid medicine can directly act on the affected part for a long time, so that the propagation of bacteria and viruses can be thoroughly inhibited, and the medicine has no toxic or side effect and is safe to use.

Description

Gynecological external antibacterial spray and preparation method thereof

Technical Field

The invention relates to the technical field of daily replacement products for female health, in particular to a gynecological external antibacterial spray and a preparation method thereof.

Background

With the acceleration of modern life rhythm, the increase of social pressure and the abuse of antibiotics, the incidence of gynecological diseases in women is higher and is in a gradually increasing state. Clinical studies have shown that: more than 95% of adult women have had gynecological inflammation problems, for example: vaginitis, pelvic inflammatory disease, adnexitis, cervical erosion, acute and chronic cervicitis, ovarian cyst, uterine cyst, cervical cyst, hysteromyoma, leucorrhea peculiar smell, dysmenorrhea and the like. However, once women suffer from gynecological inflammation, the correct method for timely treatment and accurate medication cannot be selected, which often results in persistent and recurrent inflammation. The untimely treatment of inflammation may cause a lot of complications and even malignant lesions in some parts, besides possibly causing the spread of inflammation among various physiological parts and cross infection. The inflammation is not treated, so that the body is in the inflammatory invasion environment for a long time, the adverse effects on the immune function, the metabolism and the endocrine system are generated, and the harm to the body health is great. Some gynecological inflammations not only harm women themselves, but also affect families, and if pregnant women, intrauterine infection, birth canal infection and the like can be caused to infect newborns, so that serious consequences such as abortion, premature birth, congenital development deformity and the like are caused.

There are many kinds of medicines for treating various gynecological inflammations, but the medicines are either oral medicines or lotion for external cleaning. The oral medicine has great stimulation to stomach and toxic and side effect to liver, and the medicine is easy to be damaged by digestive juice, and has slow absorption and slow effect, and the lotion is hard to reach the focus part, so the treatment effect of most medicines is not ideal. The lotion for external cleaning is mostly in a concentrated type, and the lotion needs to be diluted with water in a certain proportion during use, and then directly cleans the affected part. The product is easy to generate difference in curative effect because the dilution ratio of the liquid medicine cannot be strictly controlled; moreover, the affected part is cleaned in a short time only by using the diluent, the effective components of the medicine can not act on the affected part for a long time, the growth of germs can not be completely and effectively inhibited or the germs can not be killed, and the diseases are easy to be intermittently attacked; meanwhile, the product is limited by various conditions, cannot be used in the environment without cleaning conditions, and is not very convenient to use. In a word, no medicament with obvious curative effect for treating gynecological diseases exists at present.

At present, the gynecological lotion has a single dosage form, and in the use process of gynecological patients, the patients have poor drug experience and poor compliance, so that the bioavailability is low, the defects of unpleasant smoking pungent smell and the like exist, and in order to further improve the compliance of the clinical use of female patients and the clinical curative effect of the medicine, a novel preparation with definite curative effect and convenient use for the patients is urgently needed to be developed, which is particularly necessary.

Disclosure of Invention

In order to solve the technical problems, the first aspect of the invention provides a gynecological external antibacterial composition, which at least comprises the following components in parts by weight: 0.01-0.3 part of borneol, 0.01-0.1 part of lactobacillus fermentation product, 0.1-3 parts of radix sophorae flavescentis extract, 0.1-2 parts of cortex phellodendri extract, 0.01-0.2 part of radix stemonae extract, 0.1-2 parts of fructus cnidii extract, 0.1-0.5 part of shaddock seed extract and 0.05-0.5 part of ecological nutrient solution.

In a preferred embodiment, the compound essential oil also comprises 0.1-1 part by weight of compound essential oil.

In a preferred embodiment, the compound essential oil is prepared from at least one of eucalyptus oil, tea tree oil, lavender spica oil, rose oil, geranium oil, myrrh oil, chamomile oil, juniper oil, frankincense oil, mugwort leaf oil and motherwort herb oil.

In a preferred embodiment, the weight ratio of myrrh essential oil, tea tree essential oil, lavender essential oil and geranium essential oil is 1: (0.5-2): (0.5-2): (0.5-2).

In a preferred embodiment, the ecological nutritional liquid is a mixture of water, inulin and α -glucan oligosaccharides.

In a preferred embodiment, the weight ratio of water, inulin and α -glucan oligosaccharide is (1-5): (1-5): 1.

In a preferred embodiment, the weight ratio of the lactobacillus fermented emulsion to the ecological nutrient solution is (1-5): 1.

according to a second aspect of the invention, the daily chemical product containing the gynecological external antibacterial composition is in the form of gel, spray, lotion, cream or cream.

The third aspect of the invention provides a gynecological external antibacterial spray which at least comprises the following components in parts by weight: the gynecological external antibacterial composition of any one of claims 1 to 7, 1 to 5 parts of a thickener, 0.1 to 3 parts of a small molecular alcohol, 5 to 15 parts of a colorant, 0.1 to 0.5 part of a solvent, and the balance of 100 parts.

The fourth aspect of the invention provides a preparation method of the gynecological external antibacterial spray, which at least comprises the following steps:

(1) heating and melting borneol, adding a thickening agent, and uniformly stirring; then adding micromolecular alcohol and a lactobacillus fermentation product, and uniformly stirring to obtain a mixture;

(2) and (2) adding the solvent and the mixture prepared in the step (1) into a main pot, uniformly stirring, sequentially adding other components, uniformly stirring, and discharging to obtain the composite.

Has the advantages that: the gynecological external antibacterial composition provided by the invention can effectively inhibit various bacteria such as staphylococcus aureus, candida albicans, escherichia coli and the like, and has obvious prevention and treatment effects on vaginitis, cervical erosion, uterine prolapse, leucorrhea, peculiar smell, pelvic inflammation, adnexitis, venereal diseases due to fungal infection and chronic gynecological diseases. The gynecological external antibacterial spray provided by the invention is simple and convenient to use, only a proper amount of medicine is directly sprayed into the vagina, and the liquid medicine can directly act on the affected part for a long time, so that the propagation of bacteria and viruses can be thoroughly inhibited, and the gynecological external antibacterial spray has no toxic or side effect and is safe to use.

Detailed Description

The disclosure may be understood more readily by reference to the following detailed description of preferred embodiments of the invention and the examples included therein. Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. In case of conflict, the present specification, including definitions, will control.

The term "prepared from …" as used herein is synonymous with "comprising". The terms "comprises," "comprising," "includes," "including," "has," "having," "contains," "containing," or any other variation thereof, as used herein, are intended to cover a non-exclusive inclusion. For example, a composition, process, method, article, or apparatus that comprises a list of elements is not necessarily limited to only those elements but may include other elements not expressly listed or inherent to such composition, process, method, article, or apparatus.

The conjunction "consisting of …" excludes any unspecified elements, steps or components. If used in a claim, the phrase is intended to claim as closed, meaning that it does not contain materials other than those described, except for the conventional impurities associated therewith. When the phrase "consisting of …" appears in a clause of the subject matter of the claims rather than immediately after the subject matter, it defines only the elements described in the clause; other elements are not excluded from the claims as a whole.

When an amount, concentration, or other value or parameter is expressed as a range, preferred range, or as a range of upper preferable values and lower preferable values, this is to be understood as specifically disclosing all ranges formed from any pair of any upper range limit or preferred value and any lower range limit or preferred value, regardless of whether ranges are separately disclosed. For example, when a range of "1 to 5" is disclosed, the described range should be interpreted to include the ranges "1 to 4", "1 to 3", "1 to 2 and 4 to 5", "1 to 3 and 5", and the like. When a range of values is described herein, unless otherwise stated, the range is intended to include the endpoints thereof and all integers and fractions within the range.

The singular forms "a", "an" and "the" include plural referents unless the context clearly dictates otherwise. "optional" or "any" means that the subsequently described event or events may or may not occur, and that the description includes instances where the event occurs and instances where it does not.

Approximating language, as used herein throughout the specification and claims, is intended to modify a quantity, such that the invention is not limited to the specific quantity, but includes portions that are literally received for modification without substantial change in the basic function to which the invention is related. Accordingly, the use of "about" to modify a numerical value means that the invention is not limited to the precise value. In some instances, the approximating language may correspond to the precision of an instrument for measuring the value. In the present description and claims, range limitations may be combined and/or interchanged, including all sub-ranges contained therein if not otherwise stated.

In addition, the indefinite articles "a" and "an" preceding an element or component of the invention are not intended to limit the number requirement (i.e., the number of occurrences) of the element or component. Thus, "a" or "an" should be read to include one or at least one, and the singular form of an element or component also includes the plural unless the stated number clearly indicates that the singular form is intended.

In a preferred embodiment, the gynecological external antibacterial composition further comprises 0.1-1 part by weight of compound essential oil.

In a more preferred embodiment, the gynecological external antibacterial composition at least comprises the following components in parts by weight: 0.1 part of borneol, 0.05 part of lactobacillus fermentation product, 1 part of radix sophorae flavescentis extract, 0.5 part of cortex phellodendri extract, 0.1 part of radix stemonae extract, 0.5 part of fructus cnidii extract, 0.2 part of shaddock seed extract, 0.2 part of ecological nutrient solution and 0.2 part of compound essential oil.

Borneol (borneol)

Borneolum, named as Borneolum, pericarpium Citri Tangerinae, folium Artemisiae Argyi, Borneolum Syntheticum, Serissa, Borneolum Syntheticum, and Borneolum Syntheticum, is prepared from stems and leaves of blumea balsamifera of Compositae or branches and leaves of Cinnamomum camphora of Lauraceae by steam distillation and recrystallization. Also can be obtained by a series of chemical processes using turpentine. It can be used for treating block pattern of coma, conjunctival congestion with swelling and pain, pharyngitis, aphtha, sore and ulcer with swelling and pain, and unhealed ulcer. Ben Cao Jing Shu (the book of materia Medica Prime and Dredging): it is contraindicated for patients with apoplexy due to qi and blood deficiency, but without exogenous pathogenic wind; the infantile vomiting and diarrhea with convulsion is slow spleen wind, the acute convulsion is due to excess heat, and the slow convulsion is due to deficiency-cold; herbs should not be used for dim eyes due to deficiency of liver and kidney. "

In the present invention, the source of the borneol is not particularly limited, and can be purchased from Jia Yi good Biotechnology GmbH, Guangzhou.

Lactic acid bacteria fermentation product

Lactic Acid Bacteria (LAB) are a general term for a group of bacteria that can utilize fermentable carbohydrates to produce large amounts of lactic acid. The bacteria are widely distributed in nature, have abundant species diversity, at least comprise 18 genera, and more than 200. Except for a very small number, most of them are flora which are indispensable in human body and have important physiological functions, and are widely present in intestinal tracts of human body. Lactobacillus the lactobacillus family, named for the large amount of lactic acid produced by fermenting sugars. The product nisin has broad-spectrum antibacterial property, has strong inhibiting effect on gram-negative bacteria and gram-positive bacteria, and has antibacterial and anti-inflammatory effects.

In the present invention, the source of the lactic acid bacteria fermentation product is not particularly limited, and it can be purchased from Hangzhou Maan New materials Co.

Sophora flavescens extract

The radix Sophorae Flavescentis extract is an alkaloid extracted from Sophoraflavicens radix Sophorae Flavescentis of Sophora of Leguminosae. The raw material has tough root, coarse fibrous cross section, yellowish white color, light smell and bitter taste. The main active ingredients comprise: matrine (matrine), oxymatrine (oxymatrine), oxymatrine (sodium-anol), N-methylcardealine (N-methylcytisine), anageine (anagyrine), bap-ifinoline (bap-iifoline), dehydromatrine (sophocarpine), d-isokurarine (d-isomatrine), and kuraridine (kurarid-in). Norkurarinone, kurarinol, neo-kurarinol, norkurarinol, isokurarinone, and formononetin.

In the present invention, the source of the sophora flavescens extract is not particularly limited, and it is commercially available from Shanghai; Biotechnology Ltd.

Cortex Phellodendri extract

The main component of the phellodendron extract is Berberine (Berberine), and further contains various alkaloids such as Phellodendrine (Phellodendrine), Magnoflorine (Magnoflorine), Jatrorrhizine (Jatrorrhizine), tetrandrine (Palmatine ), N-methyl barley malt (Candicine), and menispermine (Menisperin), and further contains phellodendron lactone (obaculine), obaculone (obaculone), phellodendron acid (obaculicid), and 7-Dehydrostigmasterol (7-Dehydrostigmasterol), β -Sitosterol (β -Sitosterol), Campesterol (Campesterol), luculic acid (Lumicaceae), and dictamnolide (Dictamide).

In the present invention, the source of the phellodendron extract is not particularly limited, and the phellodendron extract is commercially available from Shanghai; Biotech, Ltd.

Stemona sessilifolia extract

Stemona extract is prepared by extracting dried rhizome of Stemona sessilifolia, Stemona japonica Thunb, etc. of Stemona of Stemonaceae. The contained alkaloid can moisten lung, expel qi, relieve cough and kill parasites. Reduce the excitability of the respiratory center, inhibit the cough reflex and achieve the effect of relieving cough. Stemona sessilifolia root tuber: contains Sessilistmonine (Sessilistmonine), hodorine (Hordonine), Tuberostemonine (Tuberostemonine), Protostemonine (Protostemonine), etc. Radix stemonae tuberous root: contains Stemonine (Stemonine), isostemonine (isostemonine), Stemonine (Stemonine), isostemonine (isostemonine) and protostemonine. Stemona tuberosa root: contains tuberostemonine, isotuberostemonine, subtupestemonine (Hypotuberite-monoine), oxypeucedanine (Oxotuberonitine), Stemine (stemmine), etc.

In the present invention, the source of the stemona root extract is not particularly limited, and can be purchased from Jiangxi Baizhentang organism.

Fructus Cnidii extract

Fructus cnidii is a plant, also called wild carrot seed, which is picked in summer and autumn, and has mild temperament and bitter taste. The fructus Cnidii extract is cnidiummonieri (L.) Cuss of Umbelliferae. The effective components of fructus Cnidii are extracted from fruit of fructus Cnidii, and comprise pinene, isobavanyl acetate, osthol, bergapten, cnidiadin, and isoanisic apiellin. Can be used as additive for health products and functional beverages.

In the present invention, the cnidium monnieri extract is not particularly limited, and can be purchased from Shanghai; Biotechnology Ltd.

Shaddock seed extract

The pomelo seed extract has strong activation effect on aromatase, the aromatase activation and the estrogen level are in a direct proportion relationship, and the local coating is favorable for improving the estrogen content and has the breast enlarging effect; has good inhibitory action on uricase, has broad-spectrum antibacterial property at the same time, and can be applied to preventing bromhidrosis; has strong eliminating effect on free radicals, and has antiaging and antioxidant effects; the compound has an activating effect on luciferase, which shows that the compound has anti-inflammation; it has effects in promoting cholesterol secretion, and increasing skin softness; has effect in promoting hyaluronic acid secretion, and can be used as humectant.

In the present invention, the source of the grapefruit seed extract is not particularly limited, and can be purchased from Jia Yi good biotechnology, Guangzhou.

In a more preferred embodiment, the weight ratio of the sophora flavescens extract, the phellodendron amurense extract, the stemona japonica extract, the cnidium monnieri fruit extract and the pomelo seed extract is 1: (0.3-0.7): (0.05-0.2): (0.3-0.7): (0.1-0.5).

In a most preferred embodiment, the weight ratio of the sophora flavescens extract, the phellodendron amurense extract, the stemona japonica extract, the cnidium monnieri fruit extract and the pomelo seed extract is 1: 0.5: 0.1: 0.5: 0.2.

the raw materials of the traditional Chinese medicine composition are rich in medicine sources, reasonable in component compatibility and synergistic, and particularly when the weight ratio of the radix sophorae flavescentis extract to the cortex phellodendri extract to the radix stemonae extract to the fructus cnidii extract to the pomelo seed extract is 1: 0.5: 0.1: 0.5: when 0.2, the traditional Chinese medicine composition has the effects of clearing away heat and toxic materials, killing viruses, relieving itching, resisting bacteria, diminishing inflammation, preventing mildew, deodorizing, promoting the production of body fluid, nourishing yin and stopping leukorrhagia, can stimulate the regeneration of histiocytes or damaged vaginal mucosa, improves the self-repairing capability and resistance, effectively enhances the self-immunity of the organism, treats both principal and secondary aspects of diseases, and ensures that the disease is not easy to relapse after treatment.

Ecological nutrient solution

In the invention, the ecological nutrient solution is a mixture of water, inulin and α -glucan oligosaccharide.

In a more preferred embodiment, the weight ratio of water, inulin and α -glucan oligosaccharide is 4: 3: 1.

In the present invention, the sources of inulin and α -glucan oligosaccharide are not particularly limited, and are commercially available from Shanghai Yan happy industries, Ltd.

In a preferred embodiment, the weight ratio of the lactic acid bacteria fermentation product to the ecological nutrient solution is (1-5): 1.

in a more preferred embodiment, the weight ratio of the lactic acid bacteria fermentation product to the ecological nutrient solution is 4: 1.

the inventor finds that the ecological nutrient solution prepared by compounding water, inulin and α -glucan oligosaccharide in a specific proportion can be used as a carbon element source of saprophytic microorganisms, can be quickly absorbed by probiotic groups such as lactic acid bacteria and the like, has the effects of remarkably proliferating lactic acid bacteria in vitro and producing acid by fermentation, competes for nutrition by reproducing more probiotics, inhibits the reproduction and growth of harmful microorganisms, improves the balance of microbial flora, blocks the combination of pathogenic bacteria and host cell receptors, establishes a protective barrier for resisting harmful microorganisms for the skin of female private parts, provides a microbial barrier and a buffer zone for the skin, regulates the pH environment of the skin, maintains the pH balance of the skin, inhibits the reproduction of the pathogenic bacteria and avoids the damage caused by the pathogenic bacteria, stimulates the immune system of the organism, improves the immunity, protects cells, preserves moisture, well keeps the mucous membrane soft, develops smooth feeling, can relieve the dry feeling after the drug application of the skin of the female, and relieves inflammation and pruritus caused by various reasons, and stimulation of a plurality of bacteria on the dry feeling after the skin, the skin is easy to lose the harmful bacteria, the biological membrane of the skin, the skin is easy to lose the biological nutrient solution, the biological membrane of the bacterial membrane, the skin is prepared by the synergistic effect of the high-resistant bacteria, the high-alkaline-resistant bacterial composition, the high-resistant bacteria, the high-alkaline-resistant bacteria, the high-resistant biological-resistant bacteria-resistant bacterial-resistant.

In addition, the pH value of the female private part is usually between 3.8 and 4.4, a weak acid environment is embodied, pathogens which are suitable for propagation in a weak alkaline environment are not easy to propagate, and the female is protected from gynecological diseases. However, once the PH changes, a range of gynecological diseases can be induced. According to the invention, by reasonably compounding the lactobacillus fermentation product and the ecological nutrient solution, the pH value of the private part of a female after the female takes the medicine can be effectively adjusted, and the increase of the pH value under the action of various alkaloids, which leads to the reproduction of a large number of pathogens, thereby causing private diseases.

In a preferred embodiment, the weight ratio of the ecological nutrient solution to the grapefruit seed extract is 1: (0.5-2).

In a more preferred embodiment, the weight ratio of the ecological nutrient solution to the grapefruit seed extract is 1: 1.

according to the invention, the compounding of the ecological nutrient solution and the pomelo seed extract can improve the drug effect, and the inventor thinks that after the ecological nutrient solution is sprayed on the skin of a female private part, the ecological nutrient solution is cooperated with propylene glycol to form a breathable and moisturizing isolating membrane which can be absorbed by the human body on the surface of the skin, so that the wound surface can be protected, a wet environment can be formed, and the ecological nutrient solution has the effects of seepage resistance, adhesion resistance, hemostasis, infection prevention, wound healing promotion and the like. More importantly, a large amount of hydroxyl has adsorption capacity and can adsorb active ingredients of the medicine, so that the retention time of the active ingredients of the medicine at the affected part is longer, the action time of the medicine is greatly prolonged, the treatment effect is more obvious, and the treatment course is shortened. Meanwhile, the pomelo seed extract not only has an antiallergic effect, but also can promote the absorption of active ingredients in the medicine by pathological parts, and further improves the curative effect.

Compound essential oil

In the invention, the preparation raw material of the compound essential oil is at least one of eucalyptus leaf essential oil, tea tree essential oil, spicebush flower lavender essential oil, rose essential oil, geranium essential oil, myrrh essential oil, chamomile essential oil, juniper essential oil, frankincense essential oil, folium artemisiae argyi essential oil and motherwort essential oil.

In a preferred embodiment, the compound essential oil is prepared from myrrh essential oil, tea tree essential oil, lavender spica essential oil and geranium essential oil.

In a more preferred embodiment, the weight ratio of myrrh essential oil, tea tree essential oil, lavender essential oil and geranium essential oil is 1: (0.5-2): (0.5-2): (0.5-2).

In a more preferred embodiment, the weight ratio of myrrh essential oil, tea tree essential oil, lavender essential oil and geranium essential oil is 1: 0.8: 1.5: 1.2.

the preparation method of the compound essential oil comprises the following steps: mixing and stirring myrrh essential oil, tea tree essential oil, spicebush flower lavender essential oil and geranium essential oil uniformly according to the weight ratio to obtain the product.

In the invention, the addition of the compound essential oil can further kill candida and eliminate private peculiar smell. The inventors believe that a possible reason is that tea tree essential oil and lavender essential oil are capable of killing fungi, in particular candida; the geranium essential oil contains citronellol, citronellyl formate, terpinene, geranic acid, geraniol, terpineol, citral, menthone and various trace mineral elements, and has effects of relieving pain, astringing, resisting bacteria, and improving vaginal dryness. The myrrh essential oil is called as 'the protection spirit of reproductive organs', and improves the healing capacity after private part medication; however, the compound essential oil has a certain stimulation effect on the skin while improving the drug effect, and the stimulation and burning feeling on the skin are multiplied under the interaction among the myrrh essential oil, the tea tree essential oil, the scilla-leaved lavender essential oil and the geranium essential oil, so that the dosage of the nursing liquid which is normally used needs to be strictly controlled. The inventor finds that by means of the reasonable dosage and component proportion, the nursing liquid can remarkably reduce irritation, burning and dry feeling of the nursing liquid to skin and reduce side effects while ensuring good sterilization effect. The inventor thinks that the possible reason is that strong van der waals force and other acting forces are formed due to the similarity and complementarity between the molecular structures of the effective components, so that the synthesis of various proteins such as hemoglobin in vivo is enhanced, meanwhile, the phenomenon that the irritant components are aggregated due to the strong intramolecular acting force to weaken the sterilization effect is avoided, and the good synergistic effect is achieved. And secondly, under the interaction between specific components, more stable and uniform micelles can be formed, effective components can be better coated and slowly released by the micelles, and the components such as high-concentration essential oil and the like are prevented from directly contacting with human bodies to cause irritation and allergy, so that the components can be better synergistic, and the sterilization performance and the refreshing and comfortable feeling are improved.

In a second aspect of the present invention, there is provided a daily chemical article comprising the gynecological external antibacterial composition as described above, wherein the daily chemical article is in the form of a gel, a spray, a lotion, a cream, or a cream.

The third aspect of the invention provides a gynecological external antibacterial spray which at least comprises the following components in parts by weight: 1-5 parts of gynecological external antibacterial composition, 0.1-3 parts of thickening agent, 5-15 parts of small molecular alcohol, 0.1-0.5 part of colorant and 100 parts of solvent complement.

In a preferred embodiment, the gynecological external antibacterial spray comprises the following components in parts by weight: 2.85 parts of gynecological external antibacterial composition, 1 part of thickening agent, 10 parts of small molecular alcohol, 0.2 part of colorant and 100 parts of solvent complement.

Small molecule alcohol

In the present invention, the small molecule alcohol is at least one selected from glycerol, butylene glycol, propylene glycol, hexylene glycol and ethanol.

In a preferred embodiment, the small molecule alcohol is a mixture of propylene glycol and ethanol.

In a more preferred embodiment, the weight ratio of propylene glycol to ethanol is 1: (0.5-1.5).

In a most preferred embodiment, the propylene glycol and ethanol are present in a weight ratio of 1: 1.

in the present invention, the source of the propylene glycol is not particularly limited, and the propylene glycol is commercially available from Shanghai Yichuan chemical science and technology Co.

Thickening agent

In the invention, the thickening agent is hydrogenated castor oil.

In a preferred embodiment, the thickener is PEG-40 hydrogenated castor oil.

In the present invention, the source of the PEG-40 hydrogenated castor oil is not particularly limited, and it can be purchased from Shanghai collaborative industry development Co., Ltd.

In a preferred embodiment, the PEG-40 hydrogenated castor oil and ethanol are present in a weight ratio of 1: (3-8).

In a more preferred embodiment, the PEG-40 hydrogenated castor oil and ethanol are present in a weight ratio of 1: 5.

the inventor finds that the solubility of each component can be obviously improved by adding a certain amount of ethanol in the experimental process to form a uniform and stable state, the ethanol can be quickly volatilized after being sprayed on the skin, the sticky feeling can not be generated, and the drug effect can not be influenced, but if the adding amount of the ethanol is too much, the solubility of the pomelo seed extract is greatly reduced, the emulsifying effect of the PEG-40 hydrogenated castor oil enhances the solubility of the pomelo seed extract, and unstable conditions such as flocculation, precipitation and the like of a spray under the environment of high temperature and the like are avoided.

Coloring agent

In the present invention, the colorant is not particularly limited, and a brown colorant is preferred.

In a preferred embodiment, the colorant is a 0.1% chocolate brown pigment solution.

In the present invention, the source of the 0.1% chocolate brown pigment solution is not particularly limited, and it can be purchased from the same chemical company, Inc. in Guangzhou.

Solvent(s)

In the present invention, the solvent is water.

In a preferred embodiment, the water is selected from one of deionized water and distilled water.

In a more preferred embodiment, the water is distilled water.

The present invention will be specifically described below by way of examples. It should be noted that the following examples are only for illustrating the present invention and should not be construed as limiting the scope of the present invention, and that the insubstantial modifications and adaptations of the present invention by those skilled in the art based on the above disclosure are still within the scope of the present invention.

In addition, the starting materials used are all commercially available, unless otherwise specified.

Examples

Example 1

The embodiment 1 provides a gynecological external antibacterial medicine spray which comprises the following components in parts by weight: 2.85 parts of gynecological external antibacterial composition, 1 part of thickening agent, 10 parts of small molecular alcohol, 0.2 part of colorant and 100 parts of solvent complement.

The gynecological external antibacterial composition comprises, by weight, 0.1 part of borneol, 0.05 part of a lactobacillus fermentation product, 1 part of a radix sophorae flavescentis extract, 0.5 part of a cortex phellodendri extract, 0.1 part of a radix stemonae extract, 0.5 part of a fructus cnidii extract, 0.2 part of a pomelo seed extract, 0.2 part of an ecological nutrient solution and 0.2 part of a compound essential oil, wherein the borneol is purchased from Jia jia, Guangzhou, the lactobacillus fermentation product is purchased from Hangzhou Maan New materials limited company, the radix sophorae flavescentis extract, the cortex phellodendri extract, the radix stemonae extract, the fructus cnidii extract and the pomelo seed extract are purchased from Jia, the weight ratio is 1: 0.5: 0.1: 0.5: 0.2, the radix sophorae flavescentis extract, the cortex phellodendri extract and the fructus cnidii extract are purchased from Shanghai Matteur limited company, the radix stemona extract is purchased from Ganozao-Hovenia Zhenzhou, the pomelo extract is purchased from Jia Limited company, the ecological nutrient solution is prepared from Bugzhou jia Yijia, the ecological nutrient solution is prepared from the mixture of water inulin, the ecological nutrient solution, the oligosaccharide and the tea plant essential oil, the tea plant essential oil is prepared from the ecological essential oil, the mixture of the tea plant essential oil, the tea plant essential oil and the ecological nutrient solution is prepared from the compound essential oil prepared from the mixture of the tea plant extract.

The micromolecular alcohol is a mixture of propylene glycol and ethanol, and the weight ratio of the micromolecular alcohol to the propylene glycol is 1: 1; the thickening agent is PEG-40 hydrogenated castor oil, and is purchased from Shanghai Xieli industry development Co., Ltd; the weight ratio of the PEG-40 hydrogenated castor oil to the ethanol is 1: 5; the colorant was a 0.1% chocolate brown solution purchased from the same chemical company, Inc. of Guangzhou; the solvent is distilled water.

The preparation method of the gynecological external antibacterial liquid medicine comprises the following steps:

Example 2

The embodiment 2 provides a gynecological external antibacterial medicine spray which comprises the following components in parts by weight: 0.58 part of gynecological external antibacterial composition, 0.1 part of thickening agent, 5 parts of micromolecular alcohol, 0.1 part of colorant and 100 parts of solvent complement.

The gynecological external antibacterial composition comprises, by weight, 0.01 part of borneol, 0.01 part of a lactobacillus fermentation product, 0.1 part of a radix sophorae flavescentis extract, 0.1 part of a cortex phellodendri extract, 0.01 part of a radix stemonae extract, 0.1 part of a fructus cnidii extract, 0.1 part of a pomelo seed extract, 0.05 part of an ecological nutrient solution and 0.1 part of a compound essential oil, wherein the borneol is purchased from Jia Yijia biological science and technology Limited, the lactobacillus fermentation product is purchased from Maan New materials Limited, Hangzhou, the radix sophorae flavescentis extract, the cortex phellodendri extract, the radix stemonae extract, the fructus cnidii extract and the pomelo seed extract are purchased from Jia biological science and technology Limited in a weight ratio of 1: 0.3: 0.05: 0.3: 0.1, the radix sophorae flavescentis extract, the cortex phellodendri extract and the fructus cnidii extract are purchased from Shanghai biological science and technology Limited, the radix stemona extract is purchased from Yijia biological science and technology Limited, the pomelo seed extract is purchased from Yizhuio biological science and the ecological nutrient solution is a mixture of water oligosaccharide, the inulin, the α -mannan essential oil is prepared from the compound essential oil and the tea plant essential oil and the mixed essential oil is prepared from the plant essential oil by a mixing method of the plant essential oil according to obtain the weight ratio of the mixed plant essential oil of the.

The micromolecular alcohol is a mixture of propylene glycol and ethanol, and the weight ratio of the micromolecular alcohol to the propylene glycol is 1: 0.5; the thickening agent is PEG-40 hydrogenated castor oil, and is purchased from Shanghai Xieli industry development Co., Ltd; the colorant was a 0.1% chocolate brown solution purchased from the same chemical company, Inc. of Guangzhou; the solvent is distilled water.

Example 3

Embodiment 3 provides a gynecological external antibacterial agent spray, which comprises the following components in parts by weight: 9.6 parts of gynecological external antibacterial composition, 3 parts of thickening agent, 15 parts of small molecular alcohol, 0.5 part of colorant and 100 parts of solvent complement.

The gynecological external antibacterial composition comprises, by weight, 0.3 part of borneol, 0.1 part of a lactobacillus fermentation product, 3 parts of a radix sophorae flavescentis extract, 2 parts of a cortex phellodendri extract, 0.2 part of a radix stemonae extract, 2 parts of a fructus cnidii extract, 0.5 part of a pomelo seed extract, 0.5 part of an ecological nutrient solution and 1 part of a compound essential oil, wherein the borneol is purchased from Guangzhou Jia Yijia biotechnology limited company, the lactobacillus fermentation product is purchased from Hangzhou Maan new materials limited company, the radix sophorae flavescentis extract, the cortex phellodendri extract, the radix stemonae extract, the fructus cnidii extract and the pomelo seed extract are purchased from Shanghai Maan New materials limited company in a weight ratio of 1: 0.7: 0.2: 0.7: 0.5, the radix sophorae flavescentis extract, the cortex phellodendri extract and the fructus cnidii extract are purchased from Shanghai Matteur biotechnology limited company, the radix stemonae extract is purchased from Baizhou Zhenzhui Zhen biology limited company, the pomelo seed extract is purchased from Guangzhou good biotechnology limited company, the ecological nutrient solution is a mixture of water, inulin oligosaccharide and α -glucan oil in a weight ratio of 1: 5: 2, the compound essential oil is prepared from the tea plant essential oil by stirring, and the plant essential oil is.

The micromolecular alcohol is a mixture of propylene glycol and ethanol, and the weight ratio of the micromolecular alcohol to the propylene glycol is 1: 1.5; the thickening agent is PEG-40 hydrogenated castor oil, and is purchased from Shanghai Xieli industry development Co., Ltd; the colorant was a 0.1% chocolate brown solution purchased from the same chemical company, Inc. of Guangzhou; the solvent is distilled water.

Example 4

Example 4 differs from example 1 in that the lactic acid bacteria fermentation product is not included.

Example 5

Example 5 differs from example 1 in that no ecological nutrient solution is included.

Example 6

Example 6 differs from example 1 in that the ecological nutrient solution does not comprise inulin.

Example 7

Example 7 differs from example 1 in that no complex essential oil is included.

Example 8

Example 8 differs from example 1 in that PEG-40 hydrogenated castor oil is not included.

Example 9

Example 9 differs from example 1 in that the PEG-40 hydrogenated castor oil and ethanol weight ratio is 1: 50.

example 10

Example 10 differs from example 1 in that grapefruit seed extract is not included.

Example 11

Example 11 differs from example 1 in that the lactic acid bacteria fermentation product is replaced by lactic acid.

Performance testing

1. Evaluation of stability

The gynecological spray prepared in the same amount of the embodiment is respectively placed at 0 ℃, 20 ℃ and 45 ℃, is kept stand for 3 months, and is observed whether the lotion is deteriorated, such as whether water-oil separation, condensation and solidification, thinning and water-changing phenomena occur, whether the color and smell are changed and whether the lotion can be normally sprayed out. And respectively scoring the stability of each group of lotion by 10 testers according to the deterioration description, wherein the scoring standard adopts a score of 5, wherein 1 is the worst score, 5 is the best score, and finally, the stability score of each group at normal temperature and high temperature is recorded by using an average numerical value. The results are shown in Table 1.

TABLE 1 stability test results for gynecological sprays provided in the examples

Examples	0℃	20℃	45℃
				Example 1	5	5	5
Example 2	5	5	5
				Example 3	5	5	5
Example 8	1.3	1.7	2.1
				Example 9	2.4	3.1	3.5
Example 10	4.0	3.9	3.2

2. Feeling of use test

The 45 test women are averagely divided into 9 groups, samples are randomly given to the test groups according to a double-blind test, and testers are required to use the test groups according to own daily habits (namely, the dosage of the spray, the use mode and the like are not limited), and the irritation and the comfort degree of use are sequentially evaluated. The testers score according to their own feelings, and the scoring standard adopts 5 grades, wherein the irritation is best according to 1 grade, and 5 grades are worst for calculation; comfort was calculated as the worst of 1 point, best of 5 points, and the sensory effect scores of each group were recorded as the average value. The results are shown in Table 2.

TABLE 2 results of the gynecological spray use test provided in the examples

Examples	Irritation property	Comfort level
			Example 1	1	5
Example 2	1	5
			Example 3	1	5
Example 4	4.3	1.8
			Example 5	3.9	2.4
Example 6	3.6	3.1
			Example 7	1.7	4.1
Example 10	1.9	3.9
			Example 11	3.9	2.3

3. Detection of bacteriostatic properties

The gynecological spray prepared in the same amount of examples is used for testing the bacteriostatic performance of escherichia coli, staphylococcus aureus and candida albicans according to the method specified in appendix C of hygienic Standard for Disposable GB15979-2002, the action time is 2min, 5min, 10min and 20min respectively, each example is repeated for 3 times, and the average value of the bactericidal rate is taken. The results are shown in Table 3.

Table 3. bacteriostatic test results of gynecological spray provided in example

The foregoing examples are merely illustrative and serve to explain some of the features of the method of the present invention. The appended claims are intended to claim as broad a scope as is contemplated, and the examples presented herein are merely illustrative of selected implementations in accordance with all possible combinations of examples. Accordingly, it is applicants' intention that the appended claims are not to be limited by the choice of examples illustrating features of the invention. Also, where numerical ranges are used in the claims, subranges therein are included, and variations in these ranges are also to be construed as possible being covered by the appended claims.

Claims

1. The gynecological external antibacterial composition is characterized by at least comprising the following components in parts by weight: 0.01-0.3 part of borneol, 0.01-0.1 part of lactobacillus fermentation product, 0.1-3 parts of radix sophorae flavescentis extract, 0.1-2 parts of cortex phellodendri extract, 0.01-0.2 part of radix stemonae extract, 0.1-2 parts of fructus cnidii extract, 0.1-0.5 part of shaddock seed extract and 0.05-0.5 part of ecological nutrient solution.

2. The gynecological external antibacterial composition according to claim 1, further comprising 0.1-1 part by weight of compound essential oil.

3. The gynecological external antibacterial composition according to claim 2, wherein the compound essential oil is prepared from at least one of eucalyptus essential oil, tea tree essential oil, lavender essential oil, rose essential oil, geranium essential oil, myrrh essential oil, chamomile essential oil, juniper essential oil, frankincense essential oil, argyi leaf essential oil and motherwort essential oil.

4. The gynecological external antibacterial composition according to claim 3, wherein the weight ratio of the myrrh essential oil, the tea tree essential oil, the lavender spica essential oil and the geranium essential oil is 1: (0.5-2): (0.5-2): (0.5-2).

5. The gynecological topical antibacterial composition according to claim 1, wherein the ecological nutrient solution is a mixture of water, inulin and α -glucan oligosaccharide.

6. The gynecological external antibacterial composition according to claim 5, wherein the weight ratio of the water, the inulin and the α -glucan oligosaccharide is (1-5): 1.

7. The gynecological external antibacterial composition according to claim 1, wherein the weight ratio of the lactobacillus fermented emulsion to the ecological nutrient solution is (1-5): 1.

8. a daily chemical product comprising the gynecological external antibacterial composition according to any one of claims 1 to 7, wherein the daily chemical product is in the form of a gel, a spray, a lotion, a cream, or a cream.

9. The gynecological external antibacterial spray is characterized by at least comprising the following components in parts by weight: the gynecological external antibacterial composition of any one of claims 1 to 7, 1 to 5 parts of a thickener, 0.1 to 3 parts of a small molecular alcohol, 5 to 15 parts of a colorant, 0.1 to 0.5 part of a solvent, and the balance of 100 parts.

10. The preparation method of the gynecological external antibacterial spray according to claim 9, characterized by comprising at least the following steps: