CN111139286B - Construction method of BCR high-throughput sequencing library - Google Patents
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Abstract
The application relates to a construction method of a BCR high-throughput sequencing library, which is characterized by comprising the following steps of: the method is based on designing a set of primer sets for heavy chain IgG and two light chain IgL and IgK of BCR, can amplify different alleles of all IgG, igL and IgK discovered at present, and simultaneously adds a set of internal reference sequences during amplification, and can truly reduce the real situation of BCR by using the correction of internal references in the later period. Three primer sets can be realized, all currently known alleles contained in IgG, igL and IgK can be completely amplified, and the defect that partial alleles can be missed when the current mixed primer is amplified is overcome; an internal reference sequence is added during PCR amplification, and the later data analysis is corrected according to the internal reference, so that the preference problem generated in the PCR process can be effectively corrected; the application can meet the requirement of sample warehouse establishment that the total RNA is more than 100 ng.
Description
Technical Field
The application belongs to the field of biomedical services, and particularly relates to amplification of human BCR, library construction and application in next generation sequencing.
Background
The immune system is mediated by the surface receptors of immune B cells, and binds to pathogens or antigens derived from pathogens, thereby exerting immune functions and protecting the body from damage. BCR immunoglobulin heavy chains (IGH) are generated by rearrangement of V, D and J gene segments to create combinatorial diversity. At the junction between V-D and D-J, the deletion of nucleotides and random addition of nucleotide sequences creates a diversity of receptor junctions. While the light chains generated by antibody immunization have similar rearrangements, thus creating a diversity of the immune system. The antibody produced by B cells is in a Y-shaped structure and consists of two identical heavy chains and light chains, and when V (D) J recombines, one of a plurality of V, D, J segments is selected and recombined to form a heavy chain variable region. Whereas the sequence upstream of the foremost V-segment, including the ATG, is called the leader region of the antibody. Each different V gene segment corresponds to a different guide region sequence that is the targeting region for the 5' end primer when amplified in the antibody repertoire.
Analysis of BCR in blood or lymphoid organs using high-throughput sequencing techniques has evolved at a very rapid rate and is increasing our knowledge of immune responses. For example, the information obtained by high-throughput DNA sequencing of immunoglobulin genes can be used for detecting B cell malignant tumors with high sensitivity, discovering antibodies specific to target antigens, guiding vaccine development and understanding autoimmunity, and the like. Thus, the study of BCR using high throughput sequencing analysis methods can facilitate our understanding of immunology and address methods of addressing unmet clinical needs associated with infectious diseases, immune disorders, and cancers.
Currently, there are two main types of existing BCR amplification and library construction techniques. 1. The library construction method based on multiplex PCR is to design a plurality of upstream primers aiming at a guide region and a downstream primer aiming at different antibody phenotypes in a constant region by taking DNA or cDNA as a template, and to amplify by using a combination of the primers in a plurality of pairs and one for amplification, and then to construct and sequence the library. 2. The library construction method based on 5 ' RACE comprises the steps of taking mRNA as a template, using oligo dT to carry out full-length synthesis of cDNA, introducing a general sequence at the 5 ' end aiming at the special structure of the 5 ' end of the mRNA during synthesis of the cDNA, then using the general sequence as an upstream primer, designing a downstream primer in a constant region, amplifying by using a pair of primers, and finally carrying out library construction and sequencing.
Although the next generation sequencing technology can rapidly perform panoramic scanning on BCR with high flux, the two methods still have obvious defects. 1. Multiple PCR methods cannot achieve equivalent amplification by using multiple primer reactions, and the existence of PCR preference is caused by different amplification efficiencies among different primers, so that the result is greatly different from the actual situation. 2. Although the simple 5' RACE method can achieve equivalent amplification, the method of double-end barcode and double-end UMI cannot be effectively combined to distinguish the cross reaction in the sample due to the length control during library construction. 3. In both amplification methods, the chimeric sequence products are present and occupy a significant proportion, but most of the cross product sequences cannot be screened by the prior art and analysis methods, which can interfere with our sample sequences and produce sequence errors between samples.
The application aims at the current problem to carry out brand-new PCR method design, can solve the current problem and achieves the aim of truly restoring the real condition of the BCR.
Disclosure of Invention
The application designs a set of primer set aiming at heavy chain IgG and two light chain IgL and IgK of BCR respectively, can amplify different alleles of all IgG, igL and IgK discovered at present, and simultaneously adds a set of internal reference sequences respectively during amplification, and can truly restore the real condition of BCR through the correction of later-stage internal reference. Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this application belongs.
Terminology:
BCR：B cell receptor
the construction method of the BCR high-throughput sequencing library is characterized by comprising the following steps of: the method is based on designing a set of primer sets for heavy chain IgG and two light chain IgL and IgK of BCR respectively, can amplify different alleles of all IgG, igL and IgK discovered at present, simultaneously respectively adds a set of internal reference sequences during amplification, and can truly reduce the real situation of BCR by using the correction of internal references in the later period
The method comprises the following steps:
s1, preparing a cDNA template: extracting cellular RNA and tissue RNA, wherein the initial quantity is more than 1mg, carrying out quality identification and concentration detection on mRNA, mixing and synthesizing the total quantity of the RNA is more than 100ng, preparing a mixed system according to certain requirements, and reacting on a PCR instrument to form a product cDNA template A;
s2, adding an internal reference sequence of 0.1ul of internal reference into the purified cDNA template A, and performing PCR reaction to form a product B;
s3, connecting the product B with a high-throughput sequencing joint to obtain a final sequencing library.
And 349 primer sequences added in the step S2 are shown in a sequence table.
The preparation of the cDNA template of the S1 comprises the following steps:
(1) Cell RNA extraction: the cell source is lymphocytes obtained by separating human peripheral blood, the number of the cells is more than 500, the cells are added with cell lysate for lysis, and RNA extraction is carried out by using an RNA extraction kit;
(2) Tissue RNA extraction: the tissue sources are tumor tissues and normal tissues which are operated by people, the initial quantity is more than 1mg, the tumor tissues and the normal tissues are ground by adopting liquid nitrogen and then are added with a lysate for cracking, and RNA extraction is carried out by using an RNA extraction kit;
(3) Performing quality identification and concentration detection on mRNA, wherein the mRNA is required to have complete results, and the total RNA amount is more than 100ng;
(4) In order to increase the yield of cDNA, we performed a pre-optimization treatment in cDNA synthesis, and prepared a mixed system according to the following table, and reacted on a PCR apparatus, the reaction procedure was: standing horse at 70deg.C for 1min, and placing the product on ice for 3min after the reaction process is completed;
(5) Preparing a mixed system in the following table, mixing the mixed system with the product in the step (4), and then placing the mixed system on a PCR instrument for reaction, wherein the reaction procedure is as follows: 42 ℃,90min,75 ℃,15min,4 ℃ and infinity, and the product after the reaction is the synthesized cDNA template A which is used for the next step;
s2 specifically comprises the following steps:
(1) Adding a cDNA template A into an internal reference sequence of 0.1ul, uniformly mixing the internal reference sequences according to the expression quantity of V genes of IgG, igK and IgL according to the corresponding proportion, adding only the corresponding internal reference sequences each time according to the requirement of amplification, adding the internal reference corresponding to the IgG if the IgG is required to be amplified, uniformly mixing to form the cDNA template A, performing PCR reaction as a template, and preparing a reaction system according to the table below;
(2) The re-PCR reaction procedure is as follows:
(3) After the reaction was completed, the product was purified, and finally eluted with 30ul of nucleic-free water to obtain product B.
The primer sequences are required as follows:
when the receptor is a human BCR IgG heavy chain: the internal reference sequence in the product cDNA template A in the step 2 comprises or consists of SEQ ID NO. 1-SEQ ID NO. 100;
when the receptor is a human BCR IgK heavy chain: the internal reference sequence in the cDNA template A in the step 2 comprises or consists of SEQ ID NO. 101-SEQ ID NO. 200;
when the receptor is a human BCR IgL heavy chain: the internal reference sequence in the cDNA template A in the step 2 comprises or consists of SEQ ID NO. 201-SEQ ID NO. 300;
when the receptor is a human BCR IgG heavy chain: the nucleotide sequence of Primer 1 in step 2 comprises or consists of SEQ ID NO. 301-SEQ ID NO. 327;
when the receptor is human BCR IgK light chain: the nucleotide sequence of Primer 1 in step 2 comprises or consists of SEQ ID NO:328-SEQ ID NO: 336;
when the receptor is human BCR IgL light chain: the nucleotide sequence of Primer 1 in step 2 comprises or consists of SEQ ID NO. 337-SEQ ID NO. 346;
when the receptor is a human BCR IgG heavy chain: the nucleotide sequence of Primer 2 in step 2 comprises or consists of SEQ ID NO. 347;
when the receptor is human BCR IgK light chain: the nucleotide sequence of Primer 2 in step 2 comprises or consists of SEQ ID NO. 348;
when the receptor is human BCR IgL light chain: the nucleotide sequence of Primer 2 in step 2 comprises or consists of SEQ ID NO. 349.
The application has the beneficial effects that:
(1) The three sets of primer sets can completely amplify all alleles contained in the currently known IgG, igL and IgK, so that the defect that part of alleles can be missed when the current mixed primer is amplified is overcome; (2) An internal reference sequence is added during PCR amplification, and the later data analysis is corrected according to the internal reference, so that the preference problem generated in the PCR process can be effectively corrected; (3) The application can meet the requirement of sample warehouse establishment that the total RNA is more than 100 ng.
Drawings
FIG. 1 is a schematic diagram of an antibody heavy chain VDJ recombination process;
FIG. 2 is a heat map of correspondence of primers to amplified genes;
FIG. 3 is a graph showing the correction of BCR expression by the reference sequence.
Detailed Description
The following examples are presented only to aid in understanding the method of the present application and its core concept, and it should be noted that it is possible for those skilled in the art to make several improvements and modifications to the present application, such as designing a primer having a length of 18bp to 30bp starting at the constant region or adjusting the number of bases of UMI, etc., without departing from the principle of the present application, and these improvements and modifications fall within the scope of the claims of the present application. The following description of the disclosed embodiments is provided to enable any person skilled in the art to make or use the application. Various modifications to these embodiments will be readily apparent to those skilled in the art, and the generic principles defined herein may be applied to other embodiments without departing from the spirit or scope of the application. Thus, the present application is not intended to be limited to the embodiments shown herein but is to be accorded the widest scope consistent with the principles and novel features disclosed herein.
Example 1 construction method of high throughput sequencing library of 1ml human peripheral blood sample BCR
Preparation of cDNA templates
(1) Collecting 1ml of human peripheral blood by using an EDTA anticoagulation tube, separating mononuclear cells in the blood by adopting a density gradient centrifugation method, adding 600ul of cell lysate for cell lysis, and extracting RNA by using an RNA extraction kit; (2) detecting the integrity of the RNA and measuring the concentration of the RNA; (3) The mixture was prepared according to the following table 5 and reacted on a PCR instrument, the reaction procedure being: after the reaction procedure was completed, the reaction was stopped by standing horse on ice for 3min at 70 ℃. TABLE 5
(4) Preparing a mixed system in the following table 6, mixing the mixed system with the product in the step (3), and then placing the mixed system on a PCR instrument for reaction, wherein the reaction procedure is as follows: 42 ℃,90min,75 ℃,15min,4 ℃ and infinity. The product after the reaction is the synthesized cDNA template C, which is used for the next experiment. TABLE 6
PCR reaction: (1) And adding 0.1ul of an internal reference sequence of IgG into the purified product C, fully and uniformly mixing to obtain a product C, and carrying out PCR reaction by taking the product C as a template to prepare a reaction system according to the table 7. TABLE 7
Primer 3 has a Primer sequence of SEQ ID NO. 301-SEQ ID NO. 327;
primer 4 has the Primer sequence of SEQ ID NO. 347.
(2) The PCR reaction procedure is shown in Table 8 below: TABLE 8
(3) After the reaction was completed, the product was purified, and finally eluted with 30ul of nucleic-free water to obtain product D.
5. Construction of sequencing library
(1) Adaptor ligation of product D using library construction kit;
(2) Screening of library fragments and identification of library quality using magnetic beads, results are shown in Table 9, table 9
Example 2: construction of BCR high throughput sequencing library of 1mg human breast cancer tissue sample
Preparation of cDNA template: (1) Taking out a human breast cancer tissue sample from liquid nitrogen or a refrigerator at the temperature of minus 80 ℃, weighing 1mg, grinding the tissue into powder by adopting a liquid nitrogen grinding method, adding 600ul of cell lysate for cell lysis, and extracting RNA by using an RNA extraction kit; (2) detecting the integrity of the RNA and measuring the concentration of the RNA; (3) The mixture was prepared according to the following table 10 and reacted on a PCR instrument, the reaction procedure being: after the reaction procedure was completed, the reaction was stopped by standing horse on ice for 3min at 70 ℃. Table 10
(4) The mixed system of the following table 11 is configured, and the mixed system is mixed with the product of the step (3) and then is placed on a PCR instrument for reaction, and the reaction procedure is as follows: 42 ℃,90min,75 ℃,15min,4 ℃ and infinity. The product after the reaction is the synthesized cDNA template, which is used for the next experiment. TABLE 11
PCR reaction: (1) Adding 0.1ul of internal reference sequence of IgG into the purified product E in the step 4, fully mixing to obtain a product E, performing PCR reaction by taking the product E as a template, and preparing a reaction system according to a table 12. Table 12
Primer 5 has a Primer sequence of SEQ ID NO. 301-SEQ ID NO. 327;
primer 6 has the Primer sequence of SEQ ID NO. 347.
(2) The PCR reaction procedure is as follows in Table 13: TABLE 13
(3) After the reaction was completed, the product was purified, and finally eluted with 30ul of nucleic-free water to obtain product F.
5. Constructing a sequencing library: (1) Using a library construction kit to adaptor-ligate product F;
(2) Library fragments were screened using magnetic beads and the quality of the library was identified, with the results shown in table 28 below.
TABLE 14
Example 3
By analysis of the respective primer sets for IgG, igL, igK, we can see that three sets of primers can amplify all alleles of the currently known IgG, igL, igK (FIG. 2):
as in fig. 2: the map is a thermal map of the correspondence between the primers and the amplified genes. The abscissa represents each allele and the ordinate represents each primer sequence, which is red if the primer can amplify the allele, or white if not. From the figure, the sequences of the primers have stronger specificity, namely, the heavy chain primers only amplify the alleles corresponding to the heavy chain, and the light chain primers only amplify the alleles corresponding to the light chain. And secondly, the primer set can amplify all alleles and can effectively measure the diversity of BCR.
Example 4
Analysis of the sequencing results of each of the libraries of IgG, igL, igK, by data correction with the addition of internal controls, we see that a significant portion of the data is effectively corrected, indeed restoring the original reality of BCR (fig. 3).
As shown in FIG. 3, this figure is a calibration of the expression of BCR by the internal reference sequence. The abscissa represents each gene and the ordinate represents the gene expression amount of the gene in the library. The blue column represents the gene expression amount uncorrected with the reference sequence, and the orange column represents the gene expression amount corrected with the reference sequence. As shown in the figure, the deviation caused by amplifying the same gene by a plurality of primers can be completely corrected by the internal reference sequence.
The results of FIGS. 2 and 3 show that the primer set used in the application can amplify all alleles of IgG, igL and IgK, so that the integrity of BCR information is ensured to the greatest extent, and meanwhile, internal references are used for correction, so that the problem that mixed primers have preference in amplification can be seen, and the real situation of BCR can be reduced by the application of the application.
Sequence listing
<110> southern Hospital at southern medical university
<120> construction method of BCR high throughput sequencing library
<141> 2019-11-07
<160> 349
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aagcagtggt atcaacgcag agtacgaggt gcagctgttg gagtctgggg gaggcttggt 60
acagcctggg gggtccctga gactcttacg cgatcgatcc tgtgcagcct ctggattcac 120
ctttagcagc tatgccatga gctgggtccg ccaggctcca gggaaggggc tggagtgggt 180
ctcagctatt agtggtagtg gtggtagcac atactacgca gactccgtga agggccggtt 240
caccatctcc agagacaatt ccaagaacac gctgtatctg caaatgaaca gcctgagagc 300
cgaggacacg gccgtatatt actatggttc gttctgggac tgaggcctgg ggccaaggaa 360
ccctggtcac cgtctcctca gacgtattcc ggaacgactt gcctggtcaa ggactacttc 420
<210> 2
<211> 419
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 2
aagcagtggt atcaacgcag agtacgaggt gcagctggtg gagtctgggg gaggcttggt 60
ccagcctggg gggtccctga gactcttgct acgacgatcc tgtgcagcct ctggattcac 120
cttcagtagc tatgctatgc actgggtccg ccaggctcca gggaagggac tggaatatgt 180
ttcagctatt agtagtaatg ggggtagcac atattatgca aactctgtga agggcagatt 240
caccatctcc agagacaatt ccaagaacac gctgtatctt caaatgggca gcctgagagc 300
tgaggacatg gctgtgtatt actgtaccgc tataggggca actggggggg gccaaggaac 360
cctggtcacc gtctcctcag actgccgaat tgacgacttg cctggtcaag gactacttc 419
<210> 3
<211> 419
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 3
aagcagtggt atcaacgcag agtacgaggt gcagctggtg gagtctgggg gaggtgtggt 60
acggcctggg gggtccctga gactctggca tagaccttcc tgtgcagcct ctggattcac 120
ctttgatgat tatggcatga gctgggtccg ccaagctcca gggaaggggc tggagtgggt 180
ctctggtatt aattggaatg gtggtagcac aggttatgca gactctgtga agggccgatt 240
caccatctcc agagacaacg ccaagaactc cctgtatctg caaatgaaca gtctgagagc 300
cgaggacacg gccttgtatc actgtacaat aaggggcttc gagttgaggg gccaaggaac 360
cctggtcacc gtctcctcag gtcgacatat cgacgacttg cctggtcaag gactacttc 419
<210> 4
<211> 424
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 4
aagcagtggt atcaacgcag agtacgaggt gcagctggtg gagtctgggg gaggcttggt 60
acagcctggg gggtccctga gactccttag gaactgctcc tgtgcagcct ctggattcac 120
cttcagtagc tacgacatgc actgggtccg ccaagctaca ggaaaaggtc tggagtgggt 180
ctcagctatt ggtactgctg gtgacacata ctatccaggc tccgtgaagg gccgattcac 240
catctccaga gaaaatgcca agaactcctt gtatcttcaa atgaacagcc tgagagccgg 300
ggacacggct gtgtattact gtacggaccc gccagccggg gtttgcacgt ctgggggcaa 360
gggaccacgg tcaccgtctc ctcaggaatt gcctacgacg acttgcctgg tcaaggacta 420
cttc 424
<210> 5
<211> 419
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 5
aagcagtggt atcaacgcag agtaccaggt gcagctgcag gagtcgggcc caggactggt 60
gaagcctccg gggaccctgt ccctccgaga tattccgacc tgcgctgtct ctggtggctc 120
catcagcagt agtaactggt ggagttgggt ccgccagccc ccagggaagg ggctggagtg 180
gattggggaa atctatcata gtgggagcac caactacaac ccgtccctca agagtcgagt 240
caccatatca gtagacaagt ccaagaacca gttctccctg aagctgagct ctgtgaccgc 300
cgcggacacg gccgtgtatt gctgtgttac cagtcctcct acggtttttg gccaagggac 360
aatggtcacc gtctcttcag ttgcgcaaga ctacgacttg cctggtcaag gactacttc 419
<210> 6
<211> 419
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 6
aagcagtggt atcaacgcag agtaccaggt gcagctggtg cagtctgggg ctgaggtgaa 60
gaagcctggg gcctcagtga aggtctaccg gaatgcttcc tgcaaggctt ctggatacac 120
cttcaccagt tatgatatca actgggtgcg acaggccact ggacaagggc ttgagtggat 180
gggatggatg aaccctaaca gtggtaacac aggctatgca cagaagttcc agggcagagt 240
caccatgacc aggaacacct ccataagcac agcctacatg gagctgagca gcctgagatc 300
tgaggacacg gccgtgtatt actgtaccac agatttcggg tccatccccg gccaaggaac 360
cctggtcacc gtctcctcag ttaggctaac cgacgacttg cctggtcaag gactacttc 419
<210> 7
<211> 419
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 7
aagcagtggt atcaacgcag agtaccaggt gcagctggtg cagtctgggg ctgaggtgaa 60
gaagcctggg gcctcagtga aggtccttgc taacggatcc tgcaaggctt ctggatacac 120
cttcaccggc tactatatgc actgggtgcg acaggcccct ggacaagggc ttgagtggat 180
gggacggatc aaccctaaca gtggtggcac aaactatgca cagaagtttc agggcagggt 240
caccagtacc agggacacgt ccatcagcac agcctacatg gagctgagca ggctgagatc 300
tgacgacacg gtcgtgtatt acccaggacc gtgcaagggc actgcctggg gccaagggac 360
aatggtcacc gtctcttcag atagcgactt cgacgacttg cctggtcaag gactacttc 419
<210> 8
<211> 422
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 8
aagcagtggt atcaacgcag agtaccagct gcagctgcag gagtcgggcc caggactggt 60
gaagccttcg gagaccctgt ccctcgtatc ggaacctacc tgcactgtct ctggtggctc 120
catcagcagt agtagttact actggggctg gatccgccag cccccaggga aggggctgga 180
gtggattggg agtatctatt atagtgggag cacctactac aacccgtccc tcaagagtcg 240
agtcaccata tccgtagaca cgtccaagaa ccagttctcc ctgaagctga gctctgtgac 300
cgccgcagac acggctgtgt attaccgtgt gaggtcggac aaacactact ggggccaagg 360
aaccctggtc accgtctcct cagtcaaggt atccgacgac ttgcctggtc aaggactact 420
tc 422
<210> 9
<211> 418
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 9
aagcagtggt atcaacgcag agtacgaggt gcagctggtg gagtctggag gaggcttgat 60
ccagcctggg gggtccctga gactccgcaa ttacgtgtcc tgtgcagcct ctgggttcac 120
cgtcagtagc aactacatga gctgggtccg ccaggctcca gggaaggggc tggagtgggt 180
ctcagttatt tatagcggtg gtagcacata ctacgcagac tccgtgaagg gccgattcac 240
catctccaga gacaattcca agaacacgct gtatcttcaa atgaacagcc tgagagccga 300
ggacacggcc gtgtattact gcgcgagagg ggactttggg gacatctagg ccaagggaca 360
atggtcaccg tctcttcagg cgacgtctaa tacgacttgc ctggtcaagg actacttc 418
<210> 10
<211> 420
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 10
aagcagtggt atcaacgcag agtaccaggt gcagctggtg cagtctgggg ctgaggtgaa 60
gaagcctggg gcctcagtga aggttatagg attccgctcc tgcaaggcat ctggatacac 120
cttcaccagc tactatatgc actgggtgcg acaggcccct ggacaagggc ttgagtggat 180
gggaataatc aaccctagtg gtggtagcac aagctacgca cagaagttcc agggcagagt 240
caccatgacc agggacacgt ccacgagcac agtctacatg gagctgagca gcctgagatc 300
tgaggacacg gccgtgtatt actgtgcgcg gattgactgg gcaaggacta ggccaaggaa 360
ccctggtcac cgtctcctca gaaggtattc gccacgactt gcctggtcaa ggactacttc 420
<210> 11
<211> 420
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 11
aagcagtggt atcaacgcag agtaccaggt tcagctggtg cagtctggag ctgaggtgaa 60
gaagcctggg gcctcagtga aggtcatcga atgctcgtcc tgcaaggctt ctggttacac 120
ctttaccagc tatggtatca gctgggtgcg acaggcccct ggacaagggc ttgagtggat 180
gggatggatc agcgcttaca atggtaacac aaactatgca cagaagctcc agggcagagt 240
caccatgacc acagacacat ccacgagcac agcctacatg gagctgagga gcctgagatc 300
tgacgacacg gccgtgtatt actgtcagca gtatggtagc tcgcactttt ggccaaggaa 360
ccctggtcac cgtctcctca gccatacgtt aggacgactt gcctggtcaa ggactacttc 420
<210> 12
<211> 416
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 12
aagcagtggt atcaacgcag agtacgaggt gcagctggtg gagtctggag gaggcttgat 60
ccagcctggg gggtccctga gactcctgaa cgattgctcc tgtgcagcct ctgggttcac 120
cgtcagtagc aactacatga gctgggtccg ccaggctcca gggaaggggc tggagtgggt 180
ctcagttatt tatagcggtg gtagcacata ctacgcagac tccgtgaagg gccgattcac 240
catctccaga gacaattcca agaacacgct gtatcttcaa atgaacagcc tgagagccga 300
ggacacggcc gtgtattact gtttgggaga tggctacccc ccgagaggcc aaggaaccct 360
ggtcaccgtc tcctcagttg caatcggaca cgacttgcct ggtcaaggac tacttc 416
<210> 13
<211> 419
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 13
aagcagtggt atcaacgcag agtacgaagt gcagctggtg gagtctgggg gagtcgtggt 60
acagcctggg gggtccctga gactctactg tacgcgatcc tgtgcagcct ctggattcac 120
ctttgatgat tataccatgc actgggtccg tcaagctccg gggaagggtc tggagtgggt 180
ctctcttatt agttgggatg gtggtagcac atactatgca gactctgtga agggccgatt 240
caccatctcc agagacaaca gcaaaaactc cctgtatctg caaatgaaca gtctgagaac 300
tgaggacacc gccttgtatt actgtgccct aggctatgat agtagtttag gccaaggaac 360
cctggtcacc gtctcctcag agagcgttac ctacgacttg cctggtcaag gactacttc 419
<210> 14
<211> 419
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 14
aagcagtggt atcaacgcag agtaccaggt gcagctggtg gagtctgggg gaggcgtggt 60
ccagcctggg aggtccctga gactcgcgat agtaccttcc tgtgcagcct ctggattcac 120
cttcagtagc tatgctatgc actgggtccg ccaggctcca ggcaaggggc tggagtgggt 180
ggcagttata tcatatgatg gaagcaataa atactacgca gactccgtga agggccgatt 240
caccatctcc agagacaatt ccaagaacac gctgtatctg caaatgaaca gcctgagagc 300
tgaggacacg gctgtgtatt accgtacgca cctcatggcg ggattattgg gccaaggaac 360
cctggtcacc gtctcctcag ttgaacacgg ctacgacttg cctggtcaag gactacttc 419
<210> 15
<211> 426
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 15
aagcagtggt atcaacgcag agtaccaggt gcagctgcag gagtcgggcc caggactggt 60
gaagccttcg gagaccctgt ccctctctta cgacggaacc tgcactgtct ctggtggctc 120
catcagtagt tactactgga gctggatccg gcagccccca gggaagggac tggagtggat 180
tgggtatatc tattacagtg ggagcaccaa ctacaacccc tccctcaaga gtcgagtcac 240
catatcagta gacacgtcca agaaccagtt ctccctgaag ctgagctctg tgaccgctgc 300
ggacacggcc gtgtattact gtgaggctgg gcgcacctac cctcctggac gtctgggggc 360
aagggaccac ggtcaccgtc tcctcaggac ttcgcgaata cgacttgcct ggtcaaggac 420
tacttc 426
<210> 16
<211> 427
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 16
aagcagtggt atcaacgcag agtaccaggt gcagctggtg gagtctgggg gaggcgtggt 60
ccagcctggg aggtccctga gactccgatt aagtcgctcc tgtgcagcgt ctggattcac 120
cttcagtagc tatggcatgc actgggtccg ccaggctcca ggcaaggggc tggagtgggt 180
ggcagttata tggtatgatg gaagtaataa atactatgca gactccgtga agggccgatt 240
caccatctcc agagacaatt ccaagaacac gctgtatctg caaatgaaca gcctgagagc 300
cgaggacacg gctgtgtatt actgtgcgat ttggctgggg tccttcgtta cgtctggggg 360
caagggacca cggtcaccgt ctcctcaggg ccttaacatg acgacttgcc tggtcaagga 420
ctacttc 427
<210> 17
<211> 422
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 17
aagcagtggt atcaacgcag agtaccagat caccttgaag gagtctggtc ctacgctggt 60
gaaacccaca cagaccctca cgctggaatt acgcgctacc tgcaccttct ctgggttctc 120
actcagcact agtggagtgg gtgtgggctg gatccgtcag cccccaggaa aggccctgga 180
gtggcttgca ctcatttatt ggaatgatga taagcgctac agcccatctc tgaagagcag 240
gctcaccatc accaaggaca cctccaaaaa ccaggtggtc cttacaatga ccaacatgga 300
ccctgtggac acagccacat attactgtgt atgtatacca ccagccctga ctggccaagg 360
aaccctggtc accgtctcct cagctcgaga tcgatacgac ttgcctggtc aaggactact 420
tc 422
<210> 18
<211> 416
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 18
aagcagtggt atcaacgcag agtacgaggt gcagctggtg gagtctgggg gaggcttggt 60
ccagcctggg gggtccctga gactccgtta tacgagctcc tgtgcagcct ctggattcac 120
cttcagtagc tatgctatgc actgggtccg ccaggctcca gggaagggac tggaatatgt 180
ttcagctatt agtagtaatg ggggtagcac atattatgca aactctgtga agggcagatt 240
caccatctcc agagacaatt ccaagaacac gctgtatctt caaatgggca gcctgagagc 300
tgaggacatg gctgtgtatt acattttcgg ttacttcgat ctctggggcc aaggaaccct 360
ggtcaccgtc tcctcagcca gtaattgcga cgacttgcct ggtcaaggac tacttc 416
<210> 19
<211> 422
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 19
aagcagtggt atcaacgcag agtaccaggt gcagctgcag gagtcgggcc caggactggt 60
gaagccttca cagaccctgt ccctctgcga ttaaccgacc tgcactgtct ctggtggctc 120
catcagcagt ggtgattact actggagttg gatccgccag cccccaggga agggcctgga 180
gtggattggg tacatctatt acagtgggag cacctactac aacccgtccc tcaagagtcg 240
agttaccata tcagtagaca cgtccaagaa ccagttctcc ctgaagctga gctctgtgac 300
tgccgcagac acggccgtgt attactgttt gggggattat ctgggaattt ggggccaagg 360
aaccctggtc accgtctcct cagaagcgcg tcttaacgac ttgcctggtc aaggactact 420
tc 422
<210> 20
<211> 419
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 20
aagcagtggt atcaacgcag agtacgaggt gcagctggtg gagtctgggg gaggcttggt 60
acagcctggg gggtccctga gactctctta ggcagactcc tgtgcagcct ctggattcac 120
cttcagtagc tatagcatga actgggtccg ccaggctcca gggaaggggc tggagtgggt 180
ttcatacatt agtagtagta gtagtaccat atactacgca gactctgtga agggccgatt 240
caccatctcc agagacaatg ccaagaactc actgtatctg caaatgaaca gcctgagagc 300
cgaggacacg gctgtgtatt actgtgcaac ctcgcaaata gagaccttgg gccaaggaac 360
cctggtcacc gtctcctcag ccgattagat cgacgacttg cctggtcaag gactacttc 419
<210> 21
<211> 419
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 21
aagcagtggt atcaacgcag agtaccaggt ccagctggta cagtctgggg ctgaggtgaa 60
gaagcctggg gcctcagtga aggtctctca cggatgatcc tgcaaggttt ccggatacac 120
cctcactgaa ttatccatgc actgggtgcg acaggctcct ggaaaagggc ttgagtggat 180
gggaggtttt gatcctgaag atggtgaaac aatctacgca cagaagttcc agggcagagt 240
caccatgacc gaggacacat ctacagacac agcctacatg gagctgagca gcctgagatc 300
tgaggacacg gccgtgtatt actgtactag acaacaaatg ccccaacccg gccaagggac 360
aatggtcacc gtctcttcag cgcgatacga ttacgacttg cctggtcaag gactacttc 419
<210> 22
<211> 423
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 22
aagcagtggt atcaacgcag agtaccaggt acagctgcag cagtcaggtc caggactggt 60
gaagccctcg cagaccctct cactctcgag ttccgaaacc tgtgccatct ccggggacag 120
tgtctctagc aacagtgctg cttggaactg gatcaggcag tccccatcga gaggccttga 180
gtggctggga aggacatact acaggtccaa gtggtataat gattatgcag tatctgtgaa 240
aagtcgaata accatcaacc cagacacatc caagaaccag ttctccctgc agctgaactc 300
tgtgactccc gaggacacgg ctgtgtatta ccacagagaa tgatgcggag tggggccaag 360
ggacaatggt caccgtctct tcagaccgct agattgacga cttgcctggt caaggactac 420
ttc 423
<210> 23
<211> 416
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 23
aagcagtggt atcaacgcag agtacgaggt gcagctggtg gagtctgggg gaggcttggt 60
ccagcctggg gggtccctga gactcattag tacggcctcc tgtgcagcct ctggattcac 120
cgtcagtagc aactacatga gctgggtccg ccaggctcca gggaaggggc tggagtgggt 180
ctcagttatt tatagcggtg gtagcacata ctacgcagac tccgtgaagg gcagattcac 240
catctccaga gacaattcca agaacacgct gtatcttcaa atgaacagcc tgagagccga 300
ggacacggct gtgtattacg ccgttcaaat aaaaggaggt tactggggcc aaggaaccct 360
ggtcaccgtc tcctcagtat cgccggataa cgacttgcct ggtcaaggac tacttc 416
<210> 24
<211> 419
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 24
aagcagtggt atcaacgcag agtaccagat gcagctggtg cagtctgggg ctgaggtgaa 60
gaagactggg tcctcagtga aggttgatcg tatgcactcc tgcaaggctt ccggatacac 120
cttcacctac cgctacctgc actgggtgcg acaggccccc ggacaagcgc ttgagtggat 180
gggatggatc acacctttca atggtaacac caactacgca cagaaattcc aggacagagt 240
caccattact agggacaggt ctatgagcac agcctacatg gagctgagca gcctgagatc 300
tgaggacaca gccatgtatt actgttccac agatttcccg cggggctttg gccaaggaac 360
cctggtcacc gtctcctcag gcaagtctta cgacgacttg cctggtcaag gactacttc 419
<210> 25
<211> 418
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 25
aagcagtggt atcaacgcag agtaccaaat gcagctggtg cagtctgggc ctgaggtgaa 60
gaagcctggg acctcagtga aggtcctcat acgaggttcc tgcaaggctt ctggattcac 120
ctttactagc tctgctgtgc agtgggtgcg acaggctcgt ggacaacgcc ttgagtggat 180
aggatggatc gtcgttggca gtggtaacac aaactacgca cagaagttcc aggaaagagt 240
caccattacc agggacatgt ccacaagcac agcctacatg gagctgagca gcctgagatc 300
cgaggacacg gccgtgtatt accggcctta atggactctg agtgctgggg ccaaggaacc 360
ctggtcaccg tctcctcagg acgttgccta aacgacttgc ctggtcaagg actacttc 418
<210> 26
<211> 419
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 26
aagcagtggt atcaacgcag agtaccaggt ccagcttgtg cagtctgggg ctgaggtgaa 60
gaagcctggg gcctcagtga aggtttcgac gatactgtcc tgcaaggctt ctggatacac 120
cttcactagc tatgctatgc attgggtgcg ccaggccccc ggacaaaggc ttgagtggat 180
gggatggatc aacgctggca atggtaacac aaaatattca cagaagttcc agggcagagt 240
caccattacc agggacacat ccgcgagcac agcctacatg gagctgagca gcctgagatc 300
tgaagacacg gctgtgtatt actgctccac acagccaccc tcttactggg gccaagggac 360
aatggtcacc gtctcttcag cgacgtattg acacgacttg cctggtcaag gactacttc 419
<210> 27
<211> 424
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 27
aagcagtggt atcaacgcag agtaccaggt gcagctggtg cagtctgggg ctgaggtgaa 60
gaagcctggg gcctcagtga aggttttagt ccaaggctcc tgcaaggcat ctggatacac 120
cttcaccagc tactatatgc actgggtgcg acaggcccct ggacaagggc ttgagtggat 180
gggaataatc aaccctagtg gtggtagcac aagctacgca cagaagttcc agggcagagt 240
caccatgacc agggacacgt ccacgagcac agtctacatg gagctgagca gcctgagatc 300
tgaggacacg gccgtgtatt acggctttag cagctcgtcc tcggggacgt ctgggggcaa 360
gggaccacgg tcaccgtctc ctcagagcga ttccgatacg acttgcctgg tcaaggacta 420
cttc 424
<210> 28
<211> 422
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 28
aagcagtggt atcaacgcag agtaccagct gcagctgcag gagtcgggcc caggactggt 60
gaagccttcg gagaccctgt ccctcgttct caagacgacc tgcactgtct ctggtggctc 120
catcagcagt agtagttact actggggctg gatccgccag cccccaggga aggggctgga 180
gtggattggg agtatctatt atagtgggag cacctactac aacccgtccc tcaagagtcg 240
agtcaccata tccgtagaca cgtccaagaa ccagttctcc ctgaagctga gctctgtgac 300
cgccgcagac acggctgtgt attactgtgt acccccccga aaactcaaac tgggccaagg 360
aaccctggtc accgtctcct caggagacat gccttacgac ttgcctggtc aaggactact 420
tc 422
<210> 29
<211> 424
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 29
aagcagtggt atcaacgcag agtaccaggt gcagctgcag gagtcgggcc caggactggt 60
gaagccttca cagaccctgt ccctccgatt gccgaatacc tgcactgtct ctggtggctc 120
catcagcagt ggtggttact actggagctg gatccgccag cacccaggga agggcctgga 180
gtggattggg tacatctatt acagtgggag cacctactac aacccgtccc tcaagagtct 240
agttaccata tcagtagaca cgtctaagaa ccagttctcc ctgaagctga gctctgtgac 300
tgccgcggac acggccgtgt attactgtgc gagagagagc cccccgacta ctggggccaa 360
ggaaccctgg tcaccgtctc ctcaggtacg tatacgcacg acttgcctgg tcaaggacta 420
cttc 424
<210> 30
<211> 421
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 30
aagcagtggt atcaacgcag agtaccagat gcagctggtg cagtctgggg ctgaggtgaa 60
gaagactggg tcctcagtga aggtttgcgt ccgaatatcc tgcaaggctt ccggatacac 120
cttcacctac cgctacctgc actgggtgcg acaggccccc ggacaagcgc ttgagtggat 180
gggatggatc acacctttca atggtaacac caactacgca cagaaattcc aggacagagt 240
caccattact agggacaggt ctatgagcac agcctacatg gagctgagca gcctgagatc 300
tgaggacaca gccatgtatt actgtgcgag tggggtcatg ttgactacgt gggccaaggg 360
acaatggtca ccgtctcttc agatgccatt gcgaacgact tgcctggtca aggactactt 420
c 421
<210> 31
<211> 419
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 31
aagcagtggt atcaacgcag agtacgaagt gcagctggtg gagtctgggg gagtcgtggt 60
acagcctggg gggtccctga gactcacgcg cgattattcc tgtgcagcct ctggattcac 120
ctttgatgat tataccatgc actgggtccg tcaagctccg gggaagggtc tggagtgggt 180
ctctcttatt agttgggatg gtggtagcac atactatgca gactctgtga agggccgatt 240
caccatctcc agagacaaca gcaaaaactc cctgtatctg caaatgaaca gtctgagaac 300
tgaggacacc gccttgtatt actgtgctgt ccttaaggat ccccagtggg gccaaggaac 360
cctggtcacc gtctcctcag actgtccgga atacgacttg cctggtcaag gactacttc 419
<210> 32
<211> 419
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 32
aagcagtggt atcaacgcag agtacgaagt gcagctggtg gagtctgggg gaggcttggt 60
acagcctggc aggtccctga gactcgaccg tacttagtcc tgtgcagcct ctggattcac 120
ctttgatgat tatgccatgc actgggtccg gcaagctcca gggaagggcc tggagtgggt 180
ctcaggtatt agttggaata gtggtagcat aggctatgcg gactctgtga agggccgatt 240
caccatctcc agagacaacg ccaagaactc cctgtatctg caaatgaaca gtctgagagc 300
tgaggacacg gccttgtatt actgcactcc ttcggggttt gtggcgtggg gccaagggac 360
aatggtcacc gtctcttcag tgtccggaca taacgacttg cctggtcaag gactacttc 419
<210> 33
<211> 419
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 33
aagcagtggt atcaacgcag agtaccaggt gcagctggtg caatctgggt ctgagttgaa 60
gaagcctggg gcctcagtga aggttgttat gccaagctcc tgcaaggctt ctggatacac 120
cttcactagc tatgctatga attgggtgcg acaggcccct ggacaagggc ttgagtggat 180
gggatggatc aacaccaaca ctgggaaccc aacgtatgcc cagggcttca caggacggtt 240
tgtcttctcc ttggacacct ctgtcagcac ggcatatctg cagatctgca gcctaaaggc 300
tgaggacact gccgtgtatt actgcaccac agggcgaata gcagctgctg gccaagggac 360
aatggtcacc gtctcttcag ggaacttacc tgacgacttg cctggtcaag gactacttc 419
<210> 34
<211> 427
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 34
aagcagtggt atcaacgcag agtacgaagt gcagctggtg gagtctgggg gaggcttggt 60
acagcctggc aggtccctga gactcttaat cgccggatcc tgtgcagcct ctggattcac 120
ctttgatgat tatgccatgc actgggtccg gcaagctcca gggaagggcc tggagtgggt 180
ctcaggtatt agttggaata gtggtagcat aggctatgcg gactctgtga agggccgatt 240
caccatctcc agagacaacg ccaagaactc cctgtatctg caaatgaaca gtctgagagc 300
tgaggacacg gccttgtatt actgtgtttg tctggatcaa gatgaatgga cgtctggggg 360
caagggacca cggtcaccgt ctcctcaggg ccatgtaact acgacttgcc tggtcaagga 420
ctacttc 427
<210> 35
<211> 419
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 35
aagcagtggt atcaacgcag agtaccaggt gcagctggtg caatctgggt ctgagttgaa 60
gaagcctggg gcctcagtga aggttgactc taagtcgtcc tgcaaggctt ctggatacac 120
cttcactagc tatgctatga attgggtgcg acaggcccct ggacaagggc ttgagtggat 180
gggatggatc aacaccaaca ctgggaaccc aacgtatgcc cagggcttca caggacggtt 240
tgtcttctcc ttggacacct ctgtcagcac ggcatatctg cagatctgca gcctaaaggc 300
tgaggacact gccgtgtatt actgcgttca tagtaatggt tacttttggg gccaaggaac 360
cctggtcacc gtctcctcag ctaatagtcg gcacgacttg cctggtcaag gactacttc 419
<210> 36
<211> 420
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 36
aagcagtggt atcaacgcag agtaccaggt tcagctggtg cagtctggag ctgaggtgaa 60
gaagcctggg gcctcagtga aggtcctatt cggaagctcc tgcaaggctt ctggttacac 120
ctttaccagc tatggtatca gctgggtgcg acaggcccct ggacaagggc ttgagtggat 180
gggatggatc agcgcttaca atggtaacac aaactatgca cagaagctcc agggcagagt 240
caccatgacc acagacacat ccacgagcac agcctacatg gagctgagga gcctgagatc 300
tgacgacacg gccgtgtatt actgttctta tgactacggt gagaggatgg ggccaaggaa 360
ccctggtcac cgtctcctca gatattcgac ggcacgactt gcctggtcaa ggactacttc 420
<210> 37
<211> 421
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 37
aagcagtggt atcaacgcag agtacgaggt ccagctggta cagtctgggg ctgaggtgaa 60
gaagcctggg gctacagtga aaatcattga cgtcgcatcc tgcaaggttt ctggatacac 120
cttcaccgac tactacatgc actgggtgca acaggcccct ggaaaagggc ttgagtggat 180
gggacttgtt gatcctgaag atggtgaaac aatatacgca gagaagttcc agggcagagt 240
caccataacc gcggacacgt ctacagacac agcctacatg gagctgagca gcctgagatc 300
tgaggacacg gccgtgtatt actgtgagac tacaacgata ttaactactg gggccaagga 360
accctggtca ccgtctcctc aggagaattc ctgcacgact tgcctggtca aggactactt 420
c 421
<210> 38
<211> 425
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 38
aagcagtggt atcaacgcag agtacgaggt gcagctggtg gagtctgggg gaggcttggt 60
ccagcctgga gggtccctga gactcttgac gcagatctcc tgtgcagcct ctggattcac 120
cttcagtgac cactacatgg actgggtccg ccaggctcca gggaaggggc tggagtgggt 180
tggccgtact agaaacaaag ctaacagtta caccacagaa tacgccgcgt ctgtgaaagg 240
cagattcacc atctcaagag atgattcaaa gaactcactg tatctgcaaa tgaacagcct 300
gaaaaccgag gacacggccg tgtattactg tgcgaaatcc tccctgagca cttgcggcca 360
aggaaccctg gtcaccgtct cctcaggaac tcgcgttaac gacttgcctg gtcaaggact 420
acttc 425
<210> 39
<211> 416
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 39
aagcagtggt atcaacgcag agtacgaggt gcagctggtg gagtctgggg gaggcttggt 60
ccagcctggg gggtccctga gactcgtaat caggccttcc tgtgcagcct ctggattcac 120
cgtcagtagc aactacatga gctgggtccg ccaggctcca gggaaggggc tggagtgggt 180
ctcagttatt tatagcggtg gtagcacata ctacgcagac tccgtgaagg gcagattcac 240
catctccaga gacaattcca agaacacgct gtatcttcaa atgaacagcc tgagagccga 300
ggacacggct gtgtattact gttatcggtc cggcgggagt atgtggggcc aagggacaat 360
ggtcaccgtc tcttcagtca aggattgcca cgacttgcct ggtcaaggac tacttc 416
<210> 40
<211> 427
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 40
aagcagtggt atcaacgcag agtacgaggt gcagctggtg gagtctgggg gaggcttggt 60
ccagcctggg gggtccctga aactcgcttc gaacatgtcc tgtgcagcct ctgggttcac 120
cttcagtggc tctgctatgc actgggtccg ccaggcttcc gggaaagggc tggagtgggt 180
tggccgtatt agaagcaaag ctaacagtta cgcgacagca tatgctgcgt cggtgaaagg 240
caggttcacc atctccagag atgattcaaa gaacacggcg tatctgcaaa tgaacagcct 300
gaaaaccgag gacacggccg tgtattactg tttgagatat gatgtcctta tgtttggggc 360
caaggaaccc tggtcaccgt ctcctcaggc gcataattcg acgacttgcc tggtcaagga 420
ctacttc 427
<210> 41
<211> 408
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 41
aagcagtggt atcaacgcag agtaccagat caccttgaag gagtctggtc ctacgctggt 60
gaaacccaca cagaccctca cgctggaacg ttctagcacc tgcaccttct ctgggttctc 120
actcagcact agtggagtgg gtgtgggctg gatccgtcag cccccaggaa aggccctgga 180
gtggcttgca ctcatttatt ggaatgatga taagcgctac agcccatctc tgaagagcag 240
gctcaccatc accaaggaca cctccaaaaa ccaggtggtc cttacaatga ccaacatgga 300
ccctgtggac acagccacat attactatgg ttcggggagg ccaagggaca atggtcaccg 360
tctcttcagg attatcacgg cacgacttgc ctggtcaagg actacttc 408
<210> 42
<211> 419
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 42
aagcagtggt atcaacgcag agtaccaggt gcagctgcag gagtcgggcc caggactggt 60
gaagccttcg gagaccctgt ccctcggtat tacgaccacc tgcgctgtct ctggttactc 120
catcagcagt ggttactact ggggctggat ccggcagccc ccagggaagg ggctggagtg 180
gattgggagt atctatcata gtgggagcac ctactacaac ccgtccctca agagtcgagt 240
caccatatca gtagacacgt ccaagaacca gttctccctg aagctgagct ctgtgaccgc 300
cgcagacacg gccgtgtatt actgtatgtg ctatacttcg ggggcttcgg gccaaggaac 360
cctggtcacc gtctcctcag taatcggacg ctacgacttg cctggtcaag gactacttc 419
<210> 43
<211> 424
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 43
aagcagtggt atcaacgcag agtaccaggt gcagctgcag gagtcgggcc caggactggt 60
gaagccttca cagaccctgt ccctcttcgc gtcaagaacc tgcactgtct ctggtggctc 120
catcagcagt ggtggttact actggagctg gatccgccag cacccaggga agggcctgga 180
gtggattggg tacatctatt acagtgggag cacctactac aacccgtccc tcaagagtct 240
agttaccata tcagtagaca cgtctaagaa ccagttctcc ctgaagctga gctctgtgac 300
tgccgcggac acggccgtgt attactctgc gaaaaaactg agtcatgcgg cacgggccaa 360
ggaaccctgg tcaccgtctc ctcagagtct cgagatcacg acttgcctgg tcaaggacta 420
cttc 424
<210> 44
<211> 421
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 44
aagcagtggt atcaacgcag agtacgaagt gcagctggtg cagtctggag cagaggtgaa 60
aaagcccggg gagtctctga ggatcccgta cggtaattcc tgtaagggtt ctggatacag 120
ctttaccagc tactggatca gctgggtgcg ccagatgccc gggaaaggcc tggagtggat 180
ggggaggatt gatcctagtg actcttatac caactacagc ccgtccttcc aaggccacgt 240
caccatctca gctgacaagt ccatcagcac tgcctacctg cagtggagca gcctgaaggc 300
ctcggacacc gccatgtatt acgggatctg gcaggtgtcg cttccttctg gggccaagga 360
accctggtca ccgtctcctc agacggattg ccatacgact tgcctggtca aggactactt 420
c 421
<210> 45
<211> 418
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 45
aagcagtggt atcaacgcag agtaccaggt gcagctgcag gagtcgggcc caggactggt 60
gaagccttcg gagaccctgt ccctcacgag gcttactacc tgcactgtct ctggtggctc 120
catcagtagt tactactgga gctggatccg gcagccccca gggaagggac tggagtggat 180
tgggtatatc tattacagtg ggagcaccaa ctacaacccc tccctcaaga gtcgagtcac 240
catatcagta gacacgtcca agaaccagtt ctccctgaag ctgagctctg tgaccgctgc 300
ggacacggcc gtgtattact gtacgaaaaa cgtggttact gcttctgggg ccaaggaacc 360
ctggtcaccg tctcctcagg cgttatccaa gacgacttgc ctggtcaagg actacttc 418
<210> 46
<211> 420
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 46
aagcagtggt atcaacgcag agtaccaggt gcagctggtg gagtctgggg gaggcgtggt 60
ccagcctggg aggtccctga gactcatcgt cggaatctcc tgtgcagcct ctggattcac 120
cttcagtagc tatgctatgc actgggtccg ccaggctcca ggcaaggggc tggagtgggt 180
ggcagttata tcatatgatg gaagcaataa atactacgca gactccgtga agggccgatt 240
caccatctcc agagacaatt ccaagaacac gctgtatctg caaatgaaca gcctgagagc 300
tgaggacacg gctgtgtatt actagcagtg gctggtactc tgcctactgg ggccaaggga 360
caatggtcac cgtctcttca ggagattatc gccacgactt gcctggtcaa ggactacttc 420
<210> 47
<211> 419
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 47
aagcagtggt atcaacgcag agtaccaggt gcagctggtg gagtctgggg gaggcgtggt 60
ccagcctggg aggtccctga gactccggaa ttgactctcc tgtgcagcgt ctggattcac 120
cttcagtagc tatggcatgc actgggtccg ccaggctcca ggcaaggggc tggagtgggt 180
ggcagttata tggtatgatg gaagtaataa atactatgca gactccgtga agggccgatt 240
caccatctcc agagacaatt ccaagaacac gctgtatctg caaatgaaca gcctgagagc 300
cgaggacacg gctgtgtatt acgcagtggc tacgagaagt gggctggtgg gccaaggaac 360
cctggtcacc gtctcctcag tacggccaag ttacgacttg cctggtcaag gactacttc 419
<210> 48
<211> 423
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 48
aagcagtggt atcaacgcag agtaccaggt gcagctgcag gagtcgggcc caggactggt 60
gaagccttcg gagaccctgt ccctcttgcc gacaatgacc tgcactgtct ctggtggctc 120
cgtcagcagt ggtagttact actggagctg gatccggcag cccccaggga agggactgga 180
gtggattggg tatatctatt acagtgggag caccaactac aacccctccc tcaagagtcg 240
agtcaccata tcagtagaca cgtccaagaa ccagttctcc ctgaagctga gctctgtgac 300
cgctgcggac acggccgtgt attactgtat aagaggggat tggtaccatc tggggccaag 360
gaaccctggt caccgtctcc tcaggcataa tcgcgtacga cttgcctggt caaggactac 420
ttc 423
<210> 49
<211> 419
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 49
aagcagtggt atcaacgcag agtacgaggt gcagctggtg gagtctgggg gaggtgtggt 60
acggcctggg gggtccctga gactcacgcg atcgtattcc tgtgcagcct ctggattcac 120
ctttgatgat tatggcatga gctgggtccg ccaagctcca gggaaggggc tggagtgggt 180
ctctggtatt aattggaatg gtggtagcac aggttatgca gactctgtga agggccgatt 240
caccatctcc agagacaacg ccaagaactc cctgtatctg caaatgaaca gtctgagagc 300
cgaggacacg gccttgtatc actgtgtgat caaccagatc gcggcagggg gccaaggaac 360
cctggtcacc gtctcctcag ccggacttaa tgacgacttg cctggtcaag gactacttc 419
<210> 50
<211> 427
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 50
aagcagtggt atcaacgcag agtacgaggt gcagctggtg gagtctgggg gaggcttggt 60
aaagcctggg gggtccctta gactcgaacc gattgcttcc tgtgcagcct ctggattcac 120
tttcagtaac gcctggatga gctgggtccg ccaggctcca gggaaggggc tggagtgggt 180
tggccgtatt aaaagcaaaa ctgatggtgg gacaacagac tacgctgcac ccgtgaaagg 240
cagattcacc atctcaagag atgattcaaa aaacacgctg tatctgcaaa tgaacagcct 300
gaaaaccgag gacacagccg tgtattacgc ccgactatgg ggatctttga ctaccggggc 360
caaggaaccc tggtcaccgt ctcctcagtt agacatggcc acgacttgcc tggtcaagga 420
ctacttc 427
<210> 51
<211> 421
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 51
aagcagtggt atcaacgcag agtacgaggt gcagctggtg gagtccgggg gaggcttagt 60
tcagcctggg gggtccctga gactcgaccg agatctttcc tgtgcagcct ctggattcac 120
cttcagtagc tactggatgc actgggtccg ccaagctcca gggaaggggc tggtgtgggt 180
ctcacgtatt aatagtgatg ggagtagcac aagctacgcg gactccgtga agggccgatt 240
caccatctcc agagacaacg ccaagaacac gctgtatctg caaatgaaca gtctgagagc 300
cgaggacacg gctgtgtatt actatgcaag gtcatttgga cagctcgttt gggccaagga 360
accctggtca ccgtctcctc agtgacgcga cttaacgact tgcctggtca aggactactt 420
c 421
<210> 52
<211> 419
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 52
aagcagtggt atcaacgcag agtaccaggt gcagctggtg gagtctgggg gaggcgtggt 60
ccagcctggg aggtccctga gactcatgga ctcacgttcc tgtgcagcct ctggattcac 120
cttcagtagc tatgctatgc actgggtccg ccaggctcca ggcaaggggc tggagtgggt 180
ggcagttata tcatatgatg gaagcaataa atactacgca gactccgtga agggccgatt 240
caccatctcc agagacaatt ccaagaacac gctgtatctg caaatgaaca gcctgagagc 300
tgaggacacg gctgtgtatt actgtatgaa tgcagagggg gaattcaagg gccaaggaac 360
cctggtcacc gtctcctcag gcagagcctt atacgacttg cctggtcaag gactacttc 419
<210> 53
<211> 416
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 53
aagcagtggt atcaacgcag agtaccaggt gcagctggtg caatctgggt ctgagttgaa 60
gaagcctggg gcctcagtga aggttattaa cggcgtctcc tgcaaggctt ctggatacac 120
cttcactagc tatgctatga attgggtgcg acaggcccct ggacaagggc ttgagtggat 180
gggatggatc aacaccaaca ctgggaaccc aacgtatgcc cagggcttca caggacggtt 240
tgtcttctcc ttggacacct ctgtcagcac ggcatatctg cagatctgca gcctaaaggc 300
tgaggacact gccgtgtatt actgttcgac ctattcattg ggctggggcc agggcaccct 360
ggtcaccgtc tcctcaggta ttccgaacga cgacttgcct ggtcaaggac tacttc 416
<210> 54
<211> 424
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 54
aagcagtggt atcaacgcag agtaccaggt gcagctggtg cagtctgggg ctgaggtgaa 60
gaagcctggg tcctcggtga aggtcgtact cggactatcc tgcaaggctt ctggaggcac 120
cttcagcagc tatgctatca gctgggtgcg acaggcccct ggacaagggc ttgagtggat 180
gggagggatc atccctatct ttggtacagc aaactacgca cagaagttcc agggcagagt 240
cacgattacc gcggacgaat ccacgagcac agcctacatg gagctgagca gcctgagatc 300
tgaggacacg gccgtgtatt actgttttgg ggggagcgtc ccatatacgt ctgggggcaa 360
gggaccacgg tcaccgtctc ctcagtagac ggcttacacg acttgcctgg tcaaggacta 420
cttc 424
<210> 55
<211> 420
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 55
aagcagtggt atcaacgcag agtaccaggt gcagctggtg cagtctgggg ctgaggtgaa 60
gaagcctggg gcctcagtga aggtcttgag aactgcctcc tgcaaggctt ctggatacac 120
cttcaccggc tactatatgc actgggtgcg acaggcccct ggacaagggc ttgagtggat 180
gggacggatc aaccctaaca gtggtggcac aaactatgca cagaagtttc agggcagggt 240
caccagtacc agggacacgt ccatcagcac agcctacatg gagctgagca ggctgagatc 300
tgacgacacg gtcgtgtatt actgtgcacc tccaaacccc gccccgctgg ggccaaggaa 360
ccctggtcac cgtctcctca gttgcaaggc ctaacgactt gcctggtcaa ggactacttc 420
<210> 56
<211> 424
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 56
aagcagtggt atcaacgcag agtacgaggt gcagctggtg gagtctgggg gaggcttggt 60
acagcctggg gggtccctga gactccaagg cgtcatttcc tgtgcagcct ctggattcac 120
cttcagtagc tatagcatga actgggtccg ccaggctcca gggaaggggc tggagtgggt 180
ttcatacatt agtagtagta gtagtaccat atactacgca gactctgtga agggccgatt 240
caccatctcc agagacaatg ccaagaactc actgtatctg caaatgaaca gcctgagagc 300
cgaggacacg gctgtgtatt acgatatttt gactggttac gtaggaacgt ctgggggcaa 360
gggaccacgg tcaccgtctc ctcagattgc gacagtcacg acttgcctgg tcaaggacta 420
cttc 424
<210> 57
<211> 424
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 57
aagcagtggt atcaacgcag agtacgaggt gcagctggtg gagtctgggg gaggcttggt 60
ccagcctggg gggtccctga gactcctgac taaggcttcc tgtgcagcct ctggattcac 120
cgtcagtagc aactacatga gctgggtccg ccaggctcca gggaaggggc tggagtgggt 180
ctcagttatt tatagcggtg gtagcacata ctacgcagac tccgtgaagg gcagattcac 240
catctccaga gacaattcca agaacacgct gtatcttcaa atgaacagcc tgagagccga 300
ggacacggct gtgtattact gtgcggatct gagttacagc gactgcacgt ctgggggcaa 360
gggaccacgg tcaccgtctc ctcagtcgtc taagacgacg acttgcctgg tcaaggacta 420
cttc 424
<210> 58
<211> 421
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 58
aagcagtggt atcaacgcag agtaccaggt ccagctggta cagtctgggg ctgaggtgaa 60
gaagcctggg gcctcagtga aggtccgaca ttcggattcc tgcaaggttt ccggatacac 120
cctcactgaa ttatccatgc actgggtgcg acaggctcct ggaaaagggc ttgagtggat 180
gggaggtttt gatcctgaag atggtgaaac aatctacgca cagaagttcc agggcagagt 240
caccatgacc gaggacacat ctacagacac agcctacatg gagctgagca gcctgagatc 300
tgaggacacg gccgtgtatt acgtgcgaga ttcttggccc cagacgtcga gggccaagga 360
accctggtca ccgtctcctc agacttacga ggctacgact tgcctggtca aggactactt 420
c 421
<210> 59
<211> 419
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 59
aagcagtggt atcaacgcag agtaccaggt gcagctggtg gagtctgggg gaggcgtggt 60
ccagcctggg aggtccctga gactcacagg cgtctattcc tgtgcagcct ctggattcac 120
cttcagtagc tatgctatgc actgggtccg ccaggctcca ggcaaggggc tagagtgggt 180
ggcagttata tcatatgatg gaagtaataa atactacgca gactccgtga agggccgatt 240
caccatctcc agagacaatt ccaagaacac gctgtatctg caaatgaaca gcctgagagc 300
tgaggacacg gctgtgtatt actgtatgaa attacaggga gtttcgctcg gccaaggaac 360
cctggtcacc gtctcctcag cgtatgcgca atacgacttg cctggtcaag gactacttc 419
<210> 60
<211> 424
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 60
aagcagtggt atcaacgcag agtaccaggt caccttgaag gagtctggtc ctgtgctggt 60
gaaacccaca gagaccctca cgctgctgag acatgtcacc tgcaccgtct ctgggttctc 120
actcagcaat gctagaatgg gtgtgagctg gatccgtcag cccccaggga aggccctgga 180
gtggcttgca cacatttttt cgaatgacga aaaatcctac agcacatctc tgaagagcag 240
gctcaccatc tccaaggaca cctccaaaag ccaggtggtc cttaccatga ccaacatgga 300
ccctgtggac acagccacat attactgttt attaacgact acattgaccg ctagggccaa 360
ggaaccctgg tcaccgtctc ctcaggaact tagtccgacg acttgcctgg tcaaggacta 420
cttc 424
<210> 61
<211> 422
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 61
aagcagtggt atcaacgcag agtaccagct gcagctgcag gagtccggct caggactggt 60
gaagccttca cagaccctgt ccctctctga caagtcgacc tgcgctgtct ctggtggctc 120
catcagcagt ggtggttact cctggagctg gatccggcag ccaccaggga agggcctgga 180
gtggattggg tacatctatc atagtgggag cacctactac aacccgtccc tcaagagtcg 240
agtcaccata tcagtagaca ggtccaagaa ccagttctcc ctgaagctga gctctgtgac 300
cgccgcggac acggccgtgt attaccgtgc tcatttccgt tcggggactt caggccaagg 360
aaccctggtc accgtctcct caggccacgt aatgtacgac ttgcctggtc aaggactact 420
tc 422
<210> 62
<211> 421
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 62
aagcagtggt atcaacgcag agtaccaggt gcagctggtg cagtctgggg ctgaggtgaa 60
gaagcctggg gcctcagtga aggtcgttcg aagatcctcc tgcaaggctt ctggatacac 120
cttcaccagt tatgatatca actgggtgcg acaggccact ggacaagggc ttgagtggat 180
gggatggatg aaccctaaca gtggtaacac aggctatgca cagaagttcc agggcagagt 240
caccatgacc aggaacacct ccataagcac agcctacatg gagctgagca gcctgagatc 300
tgaggacacg gccgtgtatt acggggggct gactggtact tcgatctctg gggccaagga 360
accctggtca ccgtctcctc agggccgatt ctaaacgact tgcctggtca aggactactt 420
c 421
<210> 63
<211> 419
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 63
aagcagtggt atcaacgcag agtaccaggt gcagctgcag gagtcgggcc caggactggt 60
gaagccttcg gagaccctgt ccctcctaag atccggtacc tgcactgtct ctggtggctc 120
cgtcagcagt ggtagttact actggagctg gatccggcag cccccaggga agggactgga 180
gtggattggg tatatctatt acagtgggag caccaactac aacccctccc tcaagagtcg 240
agtcaccata tcagtagaca cgtccaagaa ccagttctcc ctgaagctga gctctgtgac 300
cgctgcggac acggccgtgt attactgtgc ccccctaccc aaaatcgggg gccaagggac 360
aatggtcacc gtctcttcag taacggctat cgacgacttg cctggtcaag gactacttc 419
<210> 64
<211> 419
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 64
aagcagtggt atcaacgcag agtaccaggt gcagctggtg gagtctgggg gaggcttggt 60
caagcctgga gggtccctga gactcagaca ttgcgtctcc tgtgcagcct ctggattcac 120
cttcagtgac tactacatga gctggatccg ccaggctcca gggaaggggc tggagtgggt 180
ttcatacatt agtagtagtg gtagtaccat atactacgca gactctgtga agggccgatt 240
caccatctcc agggacaacg ccaagaactc actgtatctg caaatgaaca gcctgagagc 300
cgaggacacg gccgtgtatt actgtggtcc gggtatagca gcactcgggg gccaaggaac 360
cctggtcacc gtctcctcag actgaattgc gcacgacttg cctggtcaag gactacttc 419
<210> 65
<211> 420
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 65
aagcagtggt atcaacgcag agtaccaggt gcagctggtg cagtctgggg ctgaggtgaa 60
gaagcctggg gcctcagtga aggtcacgac tcggatttcc tgcaaggctt ctggatacac 120
cttcaccagt tatgatatca actgggtgcg acaggccact ggacaagggc ttgagtggat 180
gggatggatg aaccctaaca gtggtaacac aggctatgca cagaagttcc agggcagagt 240
caccatgacc aggaacacct ccataagcac agcctacatg gagctgagca gcctgagatc 300
tgaggacacg gccgtgtatt actgctcgga gatgtctaca atgaccccgg ggccaaggaa 360
ccctggtcac cgtctcctca gacgacggtt atcacgactt gcctggtcaa ggactacttc 420
<210> 66
<211> 419
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 66
aagcagtggt atcaacgcag agtacgaggt gcagctggtg gagtccgggg gaggcttagt 60
tcagcctggg gggtccctga gactctaatc gcggacttcc tgtgcagcct ctggattcac 120
cttcagtagc tactggatgc actgggtccg ccaagctcca gggaaggggc tggtgtgggt 180
ctcacgtatt aatagtgatg ggagtagcac aagctacgcg gactccgtga agggccgatt 240
caccatctcc agagacaacg ccaagaacac gctgtatctg caaatgaaca gtctgagagc 300
cgaggacacg gctgtgtatt actgtgcaca ctcgggcata ctgcttactg gccaaggaac 360
cctggtcacc gtctcctcag ccgaatgtta gcacgacttg cctggtcaag gactacttc 419
<210> 67
<211> 427
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 67
aagcagtggt atcaacgcag agtaccaggt gcagctggtg gagtctgggg gaggcgtggt 60
ccagcctggg aggtccctga gactccgata gatcgcttcc tgtgcagcgt ctggattcac 120
cttcagtagc tatggcatgc actgggtccg ccaggctcca ggcaaggggc tggagtgggt 180
ggcagttata tggtatgatg gaagtaataa atactatgca gactccgtga agggccgatt 240
caccatctcc agagacaatt ccaagaacac gctgtatctg caaatgaaca gcctgagagc 300
cgaggacacg gctgtgtatt acttcttata ggtagtgggt aggtcggaga cgtctggggg 360
caagggacca cggtcaccgt ctcctcagga ttcgcgtcaa acgacttgcc tggtcaagga 420
ctacttc 427
<210> 68
<211> 422
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 68
aagcagtggt atcaacgcag agtaccaggt caccttgagg gagtctggtc ctgcgctggt 60
gaaacccaca cagaccctca cactggcata cgagttcacc tgcaccttct ctgggttctc 120
actcagcact agtggaatgt gtgtgagctg gatccgtcag cccccaggga aggccctgga 180
gtggcttgca ctcattgatt gggatgatga taaatactac agcacatctc tgaagaccag 240
gctcaccatc tccaaggaca cctccaaaaa ccaggtggtc cttacaatga ccaacatgga 300
ccctgtggac acagccacgt attaccgtgc cacatggtcc gggagtgccg taggccaagg 360
aaccctggtc accgtctcct cagctgacgc aagttacgac ttgcctggtc aaggactact 420
tc 422
<210> 69
<211> 421
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 69
aagcagtggt atcaacgcag agtacgaggt gcagctggtg cagtctggag cagaggtgaa 60
aaagcccggg gagtctctga agatccattg agatccgtcc tgtaagggtt ctggatacag 120
ctttaccagc tactggatcg gctgggtgcg ccagatgccc gggaaaggcc tggagtggat 180
ggggatcatc tatcctggtg actctgatac cagatacagc ccgtccttcc aaggccaggt 240
caccatctca gccgacaagt ccatcagcac cgcctacctg cagtggagca gcctgaaggc 300
ctcggacacc gccatgtatt actgtaaggt gagctttggg tattaaggtg gggccaagga 360
accctggtca ccgtctcctc agaggcagta ttccacgact tgcctggtca aggactactt 420
c 421
<210> 70
<211> 419
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 70
aagcagtggt atcaacgcag agtaccaggt tcagctggtg cagtctggag ctgaggtgaa 60
gaagcctggg gcctcagtga aggtcgccat atatggctcc tgcaaggctt ctggttacac 120
ctttaccagc tatggtatca gctgggtgcg acaggcccct ggacaagggc ttgagtggat 180
gggatggatc agcgcttaca atggtaacac aaactatgca cagaagctcc agggcagagt 240
caccatgacc acagacacat ccacgagcac agcctacatg gagctgagga gcctgagatc 300
tgacgacacg gccgtgtatt actgtttaag cccaaaatta ggctactggg gccaaggaac 360
cctggtcacc gtctcctcag tattgaaccg gcacgacttg cctggtcaag gactacttc 419
<210> 71
<211> 419
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 71
aagcagtggt atcaacgcag agtacgaggt gcagctggtg gagtccgggg gaggcttagt 60
tcagcctggg gggtccctga gactcttgta ccaagcgtcc tgtgcagcct ctggattcac 120
cttcagtagc tactggatgc actgggtccg ccaagctcca gggaaggggc tggtgtgggt 180
ctcacgtatt aatagtgatg ggagtagcac aagctacgcg gactccgtga agggccgatt 240
caccatctcc agagacaacg ccaagaacac gctgtatctg caaatgaaca gtctgagagc 300
cgaggacacg gctgtgtatt actgtactat cgacgttcat tccctttggg gccaaggaac 360
cctggtcacc gtctcctcag aggacgtcat ctacgacttg cctggtcaag gactacttc 419
<210> 72
<211> 422
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 72
aagcagtggt atcaacgcag agtaccaggt caccttgaag gagtctggtc ctgtgctggt 60
gaaacccaca gagaccctca cgctgatacg ttccggaacc tgcaccgtct ctgggttctc 120
actcagcaat gctagaatgg gtgtgagctg gatccgtcag cccccaggga aggccctgga 180
gtggcttgca cacatttttt cgaatgacga aaaatcctac agcacatctc tgaagagcag 240
gctcaccatc tccaaggaca cctccaaaag ccaggtggtc cttaccatga ccaacatgga 300
ccctgtggac acagccacat attactgcgc gaaaggtgat attgatatta agggccaagg 360
gacaatggtc accgtctctt caggcaacgt tatcgacgac ttgcctggtc aaggactact 420
tc 422
<210> 73
<211> 419
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 73
aagcagtggt atcaacgcag agtacgaagt gcagctggtg gagtctgggg gagtcgtggt 60
acagcctggg gggtccctga gactctgcta agtagcctcc tgtgcagcct ctggattcac 120
ctttgatgat tataccatgc actgggtccg tcaagctccg gggaagggtc tggagtgggt 180
ctctcttatt agttgggatg gtggtagcac atactatgca gactctgtga agggccgatt 240
caccatctcc agagacaaca gcaaaaactc cctgtatctg caaatgaaca gtctgagaac 300
tgaggacacc gccttgtatt actgcgcggt cgggtggttc gacccctggg gccaagggac 360
aatggtcacc gtctcttcag acggcctaat gtacgacttg cctggtcaag gactacttc 419
<210> 74
<211> 424
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 74
aagcagtggt atcaacgcag agtaccaggt gcagctacag cagtggggcg caggactgtt 60
gaagccttcg gagaccctgt ccctccggca attatcgacc tgcgctgtct atggtgggtc 120
cttcagtggt tactactgga gctggatccg ccagccccca gggaaggggc tggagtggat 180
tggggaaatc aatcatagtg gaagcaccaa ctacaacccg tccctcaaga gtcgagtcac 240
catatcagta gacacgtcca agaaccagtt ctccctgaag ctgagctctg tgaccgccgc 300
ggacacggct gtgtattact gtgcggaagc ccacggcgga tggcccacgt ctgggggcaa 360
gggaccacgg tcaccgtctc ctcaggacta tgcgatcacg acttgcctgg tcaaggacta 420
cttc 424
<210> 75
<211> 416
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 75
aagcagtggt atcaacgcag agtacgaagt gcagctggtg gagtctgggg gaggcttggt 60
acagcctggc aggtccctga gactcctatc gaatcggtcc tgtgcagcct ctggattcac 120
ctttgatgat tatgccatgc actgggtccg gcaagctcca gggaagggcc tggagtgggt 180
ctcaggtatt agttggaata gtggtagcat aggctatgcg gactctgtga agggccgatt 240
caccatctcc agagacaacg ccaagaactc cctgtatctg caaatgaaca gtctgagagc 300
tgaggacacg gccttgtatt acccggcagc agccctagac tattggggcc aaggaaccct 360
ggtcaccgtc tcctcagatt actcggagca cgacttgcct ggtcaaggac tacttc 416
<210> 76
<211> 424
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 76
aagcagtggt atcaacgcag agtaccaggt gcagctgcag gagtcgggcc caggactggt 60
gaagcctccg gggaccctgt ccctcgacat cgattcgacc tgcgctgtct ctggtggctc 120
catcagcagt agtaactggt ggagttgggt ccgccagccc ccagggaagg ggctggagtg 180
gattggggaa atctatcata gtgggagcac caactacaac ccgtccctca agagtcgagt 240
caccatatca gtagacaagt ccaagaacca gttctccctg aagctgagct ctgtgaccgc 300
cgcggacacg gccgtgtatt gctgtgcggg ttcaaactgg aacgccacgt ctgggggcaa 360
gggaccacgg tcaccgtctc ctcagcacgg aatcgttacg acttgcctgg tcaaggacta 420
cttc 424
<210> 77
<211> 421
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 77
aagcagtggt atcaacgcag agtaccagat gcagctggtg cagtctgggg ctgaggtgaa 60
gaagactggg tcctcagtga aggttaatcg ttgccgatcc tgcaaggctt ccggatacac 120
cttcacctac cgctacctgc actgggtgcg acaggccccc ggacaagcgc ttgagtggat 180
gggatggatc acacctttca atggtaacac caactacgca cagaaattcc aggacagagt 240
caccattact agggacaggt ctatgagcac agcctacatg gagctgagca gcctgagatc 300
tgaggacaca gccatgtatt actgtttgag ccatgtccag cttccatctg gggccaagga 360
accctggtca ccgtctcctc agtgaccgaa gttcacgact tgcctggtca aggactactt 420
c 421
<210> 78
<211> 418
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 78
aagcagtggt atcaacgcag agtaccaggt gcagctgcag gagtcgggcc caggactggt 60
gaagccttcg gagaccctgt ccctcgtcta tacggacacc tgcactgtct ctggtggctc 120
catcagtagt tactactgga gctggatccg gcagccccca gggaagggac tggagtggat 180
tgggtatatc tattacagtg ggagcaccaa ctacaacccc tccctcaaga gtcgagtcac 240
catatcagta gacacgtcca agaaccagtt ctccctgaag ctgagctctg tgaccgctgc 300
ggacacggcc gtgtattact gggctggtgc ttattaatag actactgggg ccaagggaca 360
atggtcaccg tctcttcagt aaggcatgcc tacgacttgc ctggtcaagg actacttc 418
<210> 79
<211> 419
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 79
aagcagtggt atcaacgcag agtaccaggt gcagctggtg gagtctgggg gaggcttggt 60
caagcctgga gggtccctga gactcggcaa tcctatgtcc tgtgcagcct ctggattcac 120
cttcagtgac tactacatga gctggatccg ccaggctcca gggaaggggc tggagtgggt 180
ttcatacatt agtagtagtg gtagtaccat atactacgca gactctgtga agggccgatt 240
caccatctcc agggacaacg ccaagaactc actgtatctg caaatgaaca gcctgagagc 300
cgaggacacg gccgtgtatt actgttcccg atcgaccgca ggccggtggg gccaaggaac 360
cctggtcacc gtctcctcag tcgtaagacg tcacgacttg cctggtcaag gactacttc 419
<210> 80
<211> 418
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 80
aagcagtggt atcaacgcag agtaccaggt gcagctacag cagtggggcg caggactgtt 60
gaagccttcg gagaccctgt ccctcaccga attcggtacc tgcgctgtct atggtgggtc 120
cttcagtggt tactactgga gctggatccg ccagccccca gggaaggggc tggagtggat 180
tggggaaatc aatcatagtg gaagcaccaa ctacaacccg tccctcaaga gtcgagtcac 240
catatcagta gacacgtcca agaaccagtt ctccctgaag ctgagctctg tgaccgccgc 300
ggacacggct gtgtattact gtgcgggttc gatattatac taatggcggg ccaaggaacc 360
ctggtcaccg tctcctcagc ctaaggcgat tacgacttgc ctggtcaagg actacttc 418
<210> 81
<211> 421
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 81
aagcagtggt atcaacgcag agtaccaggt gcagctggtg cagtctgggg ctgaggtgaa 60
gaagcctggg tcctcggtga aggtcgattc tccaaggtcc tgcaaggctt ctggaggcac 120
cttcagcagc tatgctatca gctgggtgcg acaggcccct ggacaagggc ttgagtggat 180
gggagggatc atccctatct ttggtacagc aaactacgca cagaagttcc agggcagagt 240
cacgattacc gcggacgaat ccacgagcac agcctacatg gagctgagca gcctgagatc 300
tgaggacacg gccgtgtatt actgtgtggc tataggaaca gccggccctg gggccagggc 360
accctggtca ccgtctcctc aggcgtataa gcctacgact tgcctggtca aggactactt 420
c 421
<210> 82
<211> 421
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 82
aagcagtggt atcaacgcag agtacgaggt ccagctggta cagtctgggg ctgaggtgaa 60
gaagcctggg gctacagtga aaatcgaact ctcatggtcc tgcaaggttt ctggatacac 120
cttcaccgac tactacatgc actgggtgca acaggcccct ggaaaagggc ttgagtggat 180
gggacttgtt gatcctgaag atggtgaaac aatatacgca gagaagttcc agggcagagt 240
caccataacc gcggacacgt ctacagacac agcctacatg gagctgagca gcctgagatc 300
tgaggacacg gccgtgtatt actgagggag acatatgtcc gggcacagaa gggccaaggg 360
acaatggtca ccgtctcttc agctacggac ttgaacgact tgcctggtca aggactactt 420
c 421
<210> 83
<211> 419
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 83
aagcagtggt atcaacgcag agtacgaggt ccagctggta cagtctgggg ctgaggtgaa 60
gaagcctggg gctacagtga aaatcacggt ctatacgtcc tgcaaggttt ctggatacac 120
cttcaccgac tactacatgc actgggtgca acaggcccct ggaaaagggc ttgagtggat 180
gggacttgtt gatcctgaag atggtgaaac aatatacgca gagaagttcc agggcagagt 240
caccataacc gcggacacgt ctacagacac agcctacatg gagctgagca gcctgagatc 300
tgaggacacg gccgtgtatt actgtgcgac aagattccag tattggatcg gccaaggaac 360
cctggtcacc gtctcctcag actctaatgc ggacgacttg cctggtcaag gactacttc 419
<210> 84
<211> 419
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 84
aagcagtggt atcaacgcag agtacgaggt gcagctgttg gagtctgggg gaggcttggt 60
acagcctggg gggtccctga gactccggac cgtatattcc tgtgcagcct ctggattcac 120
ctttagcagc tatgccatga gctgggtccg ccaggctcca gggaaggggc tggagtgggt 180
ctcagctatt agtggtagtg gtggtagcac atactacgca gactccgtga agggccggtt 240
caccatctcc agagacaatt ccaagaacac gctgtatctg caaatgaaca gcctgagagc 300
cgaggacacg gccgtatatt actgcgttaa agaccccact gcgaactggg gccagggcac 360
cctggtcacc gtctcctcag tctgccaagg atacgacttg cctggtcaag gactacttc 419
<210> 85
<211> 420
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 85
aagcagtggt atcaacgcag agtaccaggt ccagctggta cagtctgggg ctgaggtgaa 60
gaagcctggg gcctcagtga aggtccttgt ccgagaatcc tgcaaggttt ccggatacac 120
cctcactgaa ttatccatgc actgggtgcg acaggctcct ggaaaagggc ttgagtggat 180
gggaggtttt gatcctgaag atggtgaaac aatctacgca cagaagttcc agggcagagt 240
caccatgacc gaggacacat ctacagacac agcctacatg gagctgagca gcctgagatc 300
tgaggacacg gccgtgtatt actgtggcgt cattgcaaac tttgactact ggccaaggaa 360
ccctggtcac cgtctcctca gactacgtag cgtacgactt gcctggtcaa ggactacttc 420
<210> 86
<211> 416
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 86
aagcagtggt atcaacgcag agtacgaggt gcagctggtg cagtctggag cagaggtgaa 60
aaagcccggg gagtctctga agatcaacgg tctcgtatcc tgtaagggtt ctggatacag 120
ctttaccagc tactggatcg gctgggtgcg ccagatgccc gggaaaggcc tggagtggat 180
ggggatcatc tatcctggtg actctgatac cagatacagc ccgtccttcc aaggccaggt 240
caccatctca gccgacaagt ccatcagcac cgcctacctg cagtggagca gcctgaaggc 300
ctcggacacc gccatgtatt actgttccca agtcgagatg gccaccggcc aaggaaccct 360
ggtcaccgtc tcctcagtag ttccggaaca cgacttgcct ggtcaaggac tacttc 416
<210> 87
<211> 419
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 87
aagcagtggt atcaacgcag agtaccaggt gcagctgcag gagtcgggcc caggactggt 60
gaagccttcg gagaccctgt ccctcgttaa cggccatacc tgcgctgtct ctggttactc 120
catcagcagt ggttactact ggggctggat ccggcagccc ccagggaagg ggctggagtg 180
gattgggagt atctatcata gtgggagcac ctactacaac ccgtccctca agagtcgagt 240
caccatatca gtagacacgt ccaagaacca gttctccctg aagctgagct ctgtgaccgc 300
cgcagacacg gccgtgtatt actgtgcaag tcatggcggg ccggggatgg gccaaggaac 360
cctggtcacc gtctcctcag gctcacgaga ttacgacttg cctggtcaag gactacttc 419
<210> 88
<211> 419
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 88
aagcagtggt atcaacgcag agtacgaggt gcagctggtg gagtctgggg gaggcctggt 60
caagcctggg gggtccctga gactctaccg gacgtattcc tgtgcagcct ctggattcac 120
cttcagtagc tatagcatga actgggtccg ccaggctcca gggaaggggc tggagtgggt 180
ctcatccatt agtagtagta gtagttacat atactacgca gactcagtga agggccgatt 240
caccatctcc agagacaacg ccaagaactc actgtatctg caaatgaaca gcctgagagc 300
cgaggacacg gctgtgtatt actgtacgag gatccccgat tacttcgggg gccaagggac 360
aatggtcacc gtctcttcag cgctagacgt taacgacttg cctggtcaag gactacttc 419
<210> 89
<211> 421
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 89
aagcagtggt atcaacgcag agtaccaggt gcagctggtg cagtctgggg ctgaggtgaa 60
gaagcctggg gcctcagtga aggtttagac gtcctgatcc tgcaaggcat ctggatacac 120
cttcaccagc tactatatgc actgggtgcg acaggcccct ggacaagggc ttgagtggat 180
gggaataatc aaccctagtg gtggtagcac aagctacgca cagaagttcc agggcagagt 240
caccatgacc agggacacgt ccacgagcac agtctacatg gagctgagca gcctgagatc 300
tgaggacacg gccgtgtatt actgtatcac atctccagta tggtagaccg gggccaagga 360
accctggtca ccgtctcctc agtgccatag gctaacgact tgcctggtca aggactactt 420
c 421
<210> 90
<211> 419
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 90
aagcagtggt atcaacgcag agtacgaagt gcagctggtg cagtctggag cagaggtgaa 60
aaagcccggg gagtctctga ggatcattgc gcgcaattcc tgtaagggtt ctggatacag 120
ctttaccagc tactggatca gctgggtgcg ccagatgccc gggaaaggcc tggagtggat 180
ggggaggatt gatcctagtg actcttatac caactacagc ccgtccttcc aaggccacgt 240
caccatctca gctgacaagt ccatcagcac tgcctacctg cagtggagca gcctgaaggc 300
ctcggacacc gccatgtatt actatgcgga atcttgtact aaatacaggg gccaaggaac 360
cctggtcacc gtctcctcag tagcggacat tcacgacttg cctggtcaag gactacttc 419
<210> 91
<211> 423
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 91
aagcagtggt atcaacgcag agtaccagat caccttgaag gagtctggtc ctacgctggt 60
gaaacccaca cagaccctca cgctgacgat tagcctgacc tgcaccttct ctgggttctc 120
actcagcact agtggagtgg gtgtgggctg gatccgtcag cccccaggaa aggccctgga 180
gtggcttgca ctcatttatt ggaatgatga taagcgctac agcccatctc tgaagagcag 240
gctcaccatc accaaggaca cctccaaaaa ccaggtggtc cttacaatga ccaacatgga 300
ccctgtggac acagccacat attactgcac gtgaaccaca tttttccgac tggggccaag 360
gaaccctggt caccgtctcc tcagtagcgc attcgaacga cttgcctggt caaggactac 420
ttc 423
<210> 92
<211> 420
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 92
aagcagtggt atcaacgcag agtaccaggt gcagctgcag gagtcgggcc caggactggt 60
gaagccttcg gacaccctgt ccctctacca ggatctgacc tgcgctgtct ctggttactc 120
catcagcagt agtaactggt ggggctggat ccggcagccc ccagggaagg gactggagtg 180
gattgggtac atctattata gtgggagcac ctactacaac ccgtccctca agagtcgagt 240
caccatgtca gtagacacgt ccaagaacca gttctccctg aagctgagct ctgtgaccgc 300
cgtggacacg gccgtgtatt actgtgcgag agaggtggac aacaatagct ggccaaggaa 360
ccctggtcac cgtctcctca ggcgaatatg ctcacgactt gcctggtcaa ggactacttc 420
<210> 93
<211> 427
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 93
aagcagtggt atcaacgcag agtaccaggt gcagctgcag gagtcgggcc caggactggt 60
gaagccttcg gagaccctgt ccctctagac cggacttacc tgcgctgtct ctggttactc 120
catcagcagt ggttactact ggggctggat ccggcagccc ccagggaagg ggctggagtg 180
gattgggagt atctatcata gtgggagcac ctactacaac ccgtccctca agagtcgagt 240
caccatatca gtagacacgt ccaagaacca gttctccctg aagctgagct ctgtgaccgc 300
cgcagacacg gccgtgtatt actgtgtgtg tacactggct ggtacgataa cgtctggggg 360
caagggacca cggtcaccgt ctcctcagga cgaatgtcct acgacttgcc tggtcaagga 420
ctacttc 427
<210> 94
<211> 421
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 94
aagcagtggt atcaacgcag agtacgaggt gcagctggtg gagtctgggg gaggcttggt 60
acagcctggg gggtccctga gactcttctg gccagaatcc tgtgcagcct ctggattcac 120
cttcagtagc tatagcatga actgggtccg ccaggctcca gggaaggggc tggagtgggt 180
ttcatacatt agtagtagta gtagtaccat atactacgca gactctgtga agggccgatt 240
caccatctcc agagacaatg ccaagaactc actgtatctg caaatgaaca gcctgagagc 300
cgaggacacg gctgtgtatt actgtgctaa ttgggggggc tgggctcctg gggccaagga 360
accctggtca ccgtctcctc agtgtcctaa ggacacgact tgcctggtca aggactactt 420
c 421
<210> 95
<211> 419
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 95
aagcagtggt atcaacgcag agtacgaggt gcagctggtg gagtctgggg gaggcttggt 60
ccagcctggg gggtccctga gactcctatt acggcgatcc tgtgcagcct ctggattcac 120
cttcagtagc tatgctatgc actgggtccg ccaggctcca gggaagggac tggaatatgt 180
ttcagctatt agtagtaatg ggggtagcac atattatgca aactctgtga agggcagatt 240
caccatctcc agagacaatt ccaagaacac gctgtatctt caaatgggca gcctgagagc 300
tgaggacatg gctgtgtatt actgtgtaac ttattactat ggttttggcg gccaaggaac 360
cctggtcacc gtctcctcag agagatcttc gcacgacttg cctggtcaag gactacttc 419
<210> 96
<211> 417
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 96
aagcagtggt atcaacgcag agtaccaggt gcagctggtg gagtctgggg gaggcgtggt 60
ccagcctggg aggtccctga gactccatgc gtaatgctcc tgtgcagcct ctggattcac 120
cttcagtagc tatgctatgc actgggtccg ccaggctcca ggcaaggggc tagagtgggt 180
ggcagttata tcatatgatg gaagtaataa atactacgca gactccgtga agggccgatt 240
caccatctcc agagacaatt ccaagaacac gctgtatctg caaatgaaca gcctgagagc 300
tgaggacacg gctgtgtatt acagctcacg tctatcccga ctactggggc caagggacaa 360
tggtcaccgt ctcttcaggc taatacgtgc acgacttgcc tggtcaagga ctacttc 417
<210> 97
<211> 418
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 97
aagcagtggt atcaacgcag agtacgaggt gcagctggtg gagtctgggg gaggcttggt 60
acagcctggg gggtccctga gactcaagag ttccgtctcc tgtgcagcct ctggattcac 120
cttcagtagc tacgacatgc actgggtccg ccaagctaca ggaaaaggtc tggagtgggt 180
ctcagctatt ggtactgctg gtgacacata ctatccaggc tccgtgaagg gccgattcac 240
catctccaga gaaaatgcca agaactcctt gtatcttcaa atgaacagcc tgagagccgg 300
ggacacggct gtgtattacc cctatgagac tagtgattct taaattgggg ccaagggaca 360
atggtcaccg tctcttcagc gacgacgtta tacgacttgc ctggtcaagg actacttc 418
<210> 98
<211> 424
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 98
aagcagtggt atcaacgcag agtaccaggt gcagctgcag gagtcgggcc caggactggt 60
gaagccttca cagaccctgt ccctctgcga acgtactacc tgcactgtct ctggtggctc 120
catcagcagt ggtggttact actggagctg gatccgccag cacccaggga agggcctgga 180
gtggattggg tacatctatt acagtgggag cacctactac aacccgtccc tcaagagtct 240
agttaccata tcagtagaca cgtctaagaa ccagttctcc ctgaagctga gctctgtgac 300
tgccgcggac acggccgtgt attactgtgt cctgctgctc cacttgactc ctggggccaa 360
gggacaatgg tcaccgtctc ttcaggactc taggctaacg acttgcctgg tcaaggacta 420
cttc 424
<210> 99
<211> 416
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 99
aagcagtggt atcaacgcag agtacgaggt gcagctggtg gagtctgggg gaggcttggt 60
ccagcctggg gggtccctga gactctgatc gctaacgtcc tgtgcagcct ctggattcac 120
ctttagtagc tattggatga gctgggtccg ccaggctcca gggaaggggc tggagtgggt 180
ggccaacata aagcaagatg gaagtgagaa atactatgtg gactctgtga agggccgatt 240
caccatctcc agagacaacg ccaagaactc actgtatctg caaatgaaca gcctgagagc 300
cgaggacacg gctgtgtatt actgtttgtc ggggcctgct ggctcgggcc aaggaaccct 360
ggtcaccgtc tcctcagatc gaacgcgtta cgacttgcct ggtcaaggac tacttc 416
<210> 100
<211> 417
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 100
aagcagtggt atcaacgcag agtaccaggt gcagctggtg gagtctgggg gaggcgtggt 60
ccagcctggg aggtccctga gactccgcga taatgtctcc tgtgcagcct ctggattcac 120
cttcagtagc tatgctatgc actgggtccg ccaggctcca ggcaaggggc tagagtgggt 180
ggcagttata tcatatgatg gaagtaataa atactacgca gactccgtga agggccgatt 240
caccatctcc agagacaatt ccaagaacac gctgtatctg caaatgaaca gcctgagagc 300
tgaggacacg gctgtgtatt actggcgtcg cctggaactt cgggacaggc caaggaaccc 360
tggtcaccgt ctcctcaggc ggccaatatt acgacttgcc tggtcaagga ctacttc 417
<210> 101
<211> 385
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 101
gaaacgacac tcacgcagtc tccagcattc atgtcagcga ctccaggaga aagcgttacc 60
tgcaaagtca acatctcctg caaagccagc caagacattg atgatgatat gaactggtac 120
caacagaaac caggagaagc tgctattttc attattcaag aagctactac tctcgttcct 180
ggaatcccac ctcgattcag tggcagcggg tatggaacag attttaccct cacaattaat 240
aacatagaat ctgaggatgc tgcatattac ttctgtctac aacatgataa tttccctctg 300
atcaccttcg gccaagggac acgactggag attaaacatc ctcgggtaaa tgctactgtg 360
gctgcaccat ctgtcttcat cttcc 385
<210> 102
<211> 400
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 102
gatgttgtga tgactcagtc tccactctcc ctgcccgtca cccttggaca accgcggtta 60
tagccggcct ccatctcctg caggtctagt caaagcctcg tatacagtga tggaaacacc 120
tacttgaatt ggtttcagca gaggccaggc caatctccaa ggcgcctaat ttataaggtt 180
tctaaccggg actctggggt cccagacaga ttcagcggca gtgggtcagg cactgatttc 240
acactgaaaa tcagcagggt ggaggctgag gatgttgggg tttattactg catgcaaggt 300
acacactggc ctccgctcac gttcggcgga gggaccaagg tggagatcaa acatcggtcg 360
ctaaatgcta ctgtggctgc accatctgtc ttcatcttcc 400
<210> 103
<211> 385
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 103
gaaattgtgt tgacacagtc tccagccacc ctgtctttgt ctccagggga gtttccacgg 60
aaaagagcca ccctctcctg cagggccagt cagagtgtta gcagctactt agcctggtac 120
caacagaaac ctggccaggc tcccaggctc ctcatctatg atgcatccaa cagggccact 180
ggcatcccag ccaggttcag tggcagtggg tctgggacag acttcactct caccatcagc 240
agcctagagc ctgaagattt tgcagtttat tactgtcagc agcgtagcaa ctggcctccg 300
ctcactttcg gcggagggac caaggtggag atcaaaccta agcttgcgaa tgctactgtg 360
gctgcaccat ctgtcttcat cttcc 385
<210> 104
<211> 385
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 104
gacatccaga tgacccagtc tccatcctca ctgtctgcat ctgtaggaga ctggcgctta 60
aacagagtca ccatcacttg tcgggcgagt cagggcatta gcaattattt agcctggttt 120
cagcagaaac cagggaaagc ccctaagtcc ctgatctatg ctgcatccag tttgcaaagt 180
ggggtcccat caaagttcag cggcagtgga tctgggacag atttcactct caccatcagc 240
agcctgcagc ctgaagattt tgcaacttat tactgccaac agtataatag ttaccctccg 300
tggacgttcg gccaagggac caaggtggaa atcaaactag gaccttgcaa tgctactgtg 360
gctgcaccat ctgtcttcat cttcc 385
<210> 105
<211> 397
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 105
gacattgtgc tgacccagtc tccagcctcc ttggccgtgt ctccaggaca tccctagaga 60
gtgagggcca ccatcacctg cagagccagt gagagtgtca gtttcttggg aataaactta 120
attcactggt atcagcagaa accaggacaa cctcctaaac tcctgattta ccaagcatcc 180
aataaagaca ctggggtccc agccaggttc agcggcagtg ggtctgggac cgatttcacc 240
ctcacaatta atcctgtgga agctaatgat actgcaaatt attactgtct gcagagtaag 300
aattttcctc cgctcacgtt cggcggaggg accaaggtgg agatcaaacc tctatagacg 360
gatgctactg tggctgcacc atctgtcttc atcttcc 397
<210> 106
<211> 385
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 106
gacatccaga tgacccagtc tccttccacc ctgtctgcat ctgtaggaga gcacttaagg 60
tccagagtca ccatcacttg ccgggccagt cagagtatta gtagctggtt ggcctggtat 120
cagcagaaac cagggaaagc ccctaagctc ctgatctatg atgcctccag tttggaaagt 180
ggggtcccat caaggttcag cggcagtgga tctgggacag aattcactct caccatcagc 240
agcctgcagc ctgatgattt tgcaacttat tactgccaac agtataatag ttattctccg 300
tgcacttttg gccaggggac caagctggag atcaaactgg ccaagctata tgctactgtg 360
gctgcaccat ctgtcttcat cttcc 385
<210> 107
<211> 385
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 107
gaaattgtgt tgacacagtc tccagccacc ctgtctttgt ctccagggga caaggacctt 60
gtaagagcca ccctctcctg cagggccagt cagagtgtta gcagctactt agcctggtac 120
caacagaaac ctggccaggc tcccaggctc ctcatctatg atgcatccaa cagggccact 180
ggcatcccag ccaggttcag tggcagtggg tctgggacag acttcactct caccatcagc 240
agcctagagc ctgaagattt tgcagtttat tactgtcagc agcgtagcaa ctggcctccg 300
ctcacgttcg gcggagggac caaggtggag atcaaaccaa gccttggata tgctactgtg 360
gctgcaccat ctgtcttcat cttcc 385
<210> 108
<211> 385
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 108
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ggttactgca 60
accagagtca ccatcacttg ccgggcaagt cagagcatta gcagctattt aaattggtat 120
cagcagaaac cagggaaagc ccctaagctc ctgatctatg ctgcatccag tttgcaaagt 180
ggggtcccat caaggttcag tggcagtgga tctgggacag atttcactct caccatcagc 240
agtctgcaac ctgaagattt tgcaacttac tactgtcaac agagttacag tacccctccg 300
ctcacgttcg gcggagggac caaggtggag atcaaactcc aggcttaaga tgctactgtg 360
gctgcaccat ctgtcttcat cttcc 385
<210> 109
<211> 400
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 109
gatattgtga tgacccagca tctgctctcc ctgcccatcc ctctgggaga gtaagtagcc 60
tcgccggcct ccatctcctg caggtctagt cagagcctcc tgcatagtga tggaaacacc 120
tatttggatt ggtacctgca gaagccaggc cagtctccac agcttcttat ctacacaatt 180
tctaacaaat tctatggagt cccaaacaag ttcagtggca gcaggtcagg gacaggtttc 240
acacttaaat tcagcaaagt ggaggctgag gatgttgggg tttattgctg tgaacagggt 300
ctgcaaggtc ctcagctcac tttcggcgga gggaccaagg tggagatcaa acccgaattc 360
gtagatgcta ctgtggctgc accatctgtc ttcatcttcc 400
<210> 110
<211> 388
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 110
gaaattgtgt tgacgcagtc tccaggcacc ctgtctttgt ctccagggga cggagacact 60
ttaagagcca ccctctcctg cagggccagt cagagtgtta gcagcagcta cttagcctgg 120
taccagcaga aacctggcca ggctcccagg ctcctcatct atggtgcatc cagcagggcc 180
actggcatcc cagacaggtt cagtggcagt gggtctggga cagacttcac tctcaccatc 240
agcagactgg agcctgaaga ttttgcagtg tattactgtc agcagtatgg tagctcacct 300
ccgtggacgt tcggccaagg gaccaaggtg gaaatcaaac tcgcttaaag gcatgctact 360
gtggctgcac catctgtctt catcttcc 388
<210> 111
<211> 385
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 111
gaaatagtga tgacgcagtc tccagccacc ctgtctgtgt ctccagggga ttgacctagg 60
acaagagcca ccctctcctg cagggccagt cagagtgtta gcagcaactt agcctggtac 120
cagcagaaac ctggccaggc tcccaggctc ctcatctatg gtgcatccac cagggccact 180
ggtatcccag ccaggttcag tggcagtggg tctgggacag agttcactct caccatcagc 240
agcctgcagt ctgaagattt tgcagtttat tactgtcagc agtataataa ctggcctccg 300
atcaccttcg gccaagggac acgactggag attaaacatg acggatccta tgctactgtg 360
gctgcaccat ctgtcttcat cttcc 385
<210> 112
<211> 403
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 112
gatattgtga tgacccagac tccactctcc ctgcccgtca cccctggaga agtatcgcta 60
gcgccggcct ccatctcctg caggtctagt cagagcctct tggatagtga tgatggaaac 120
acctatttgg actggtacct gcagaagcca gggcagtctc cacagctcct gatctatacg 180
ctttcctatc gggcctctgg agtcccagac aggttcagtg gcagtgggtc aggcactgat 240
ttcacactga aaatcagcag ggtggaggct gaggatgttg gagtttatta ctgcatgcaa 300
cgtatagagt ttccttcgct cacgttcggc ggagggacca aggtggagat caaaccacgt 360
ttggcaaatg ctactgtggc tgcaccatct gtcttcatct tcc 403
<210> 113
<211> 385
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 113
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ggacaatctt 60
cgcagagtca ccatcacttg ccaggcgagt caggacatta gcaactattt aaattggtat 120
cagcagaaac cagggaaagc ccctaagctc ctgatctacg atgcatccaa tttggaaaca 180
ggggtcccat caaggttcag tggaagtgga tctgggacag attttacttt caccatcagc 240
agcctgcagc ctgaagatat tgcaacatat tactgtcaac agtatgataa tctccctccg 300
atcaccttcg gccaagggac acgactggag attaaaccag aggtcatcta tgctactgtg 360
gctgcaccat ctgtcttcat cttcc 385
<210> 114
<211> 385
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 114
gacatccaga tgacccagtc tccttccacc ctgtctgcat ctgtaggaga ggccgctaat 60
tacagagtca ccatcacttg ccgggccagt cagagtatta gtagctggtt ggcctggtat 120
cagcagaaac cagggaaagc ccctaagctc ctgatctatg atgcctccag tttggaaagt 180
ggggtcccat caaggttcag cggcagtgga tctgggacag aattcactct caccatcagc 240
agcctgcagc ctgatgattt tgcaacttat tactgccaac agtataatag ttattctccg 300
ctcacgttcg gcggagggac caaggtggag atcaaacgcc tatagcgtaa tgctactgtg 360
gctgcaccat ctgtcttcat cttcc 385
<210> 115
<211> 397
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 115
gacattgtgc tgacccagtc tccagcctcc ttggccgtgt ctccaggaca actggacatt 60
gcgagggcca ccatcacctg cagagccagt gagagtgtca gtttcttggg aataaactta 120
attcactggt atcagcagaa accaggacaa cctcctaaac tcctgattta ccaagcatcc 180
aataaagaca ctggggtccc agccaggttc agcggcagtg ggtctgggac cgatttcacc 240
ctcacaatta atcctgtgga agctaatgat actgcaaatt attactgtct gcagagtaag 300
aattttcctc cgatcacctt cggccaaggg acacgactgg agattaaacc taaatgctgg 360
catgctactg tggctgcacc atctgtcttc atcttcc 397
<210> 116
<211> 385
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 116
gaaattgtgt tgacacagtc tccagccacc ctgtctttgt ctccagggga catggtcaac 60
tgaagagcca ccctctcctg cagggccagt cagagtgtta gcagctactt agcctggtac 120
caacagaaac ctggccaggc tcccaggctc ctcatctatg atgcatccaa cagggccact 180
ggcatcccag ccaggttcag tggcagtggg tctgggagag acttcactct caccatcagc 240
agcctagagc ctgaagattt tgcagtttat tactgtcagc agcgtagcaa ctggcctccg 300
ctcacgttcg gcggagggac caaggtggag atcaaacgct caatgtagca tgctactgtg 360
gctgcaccat ctgtcttcat cttcc 385
<210> 117
<211> 385
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 117
gacatccaga tgacccagtc tccatccttc ctgtctgcat ctgtaggaga ccgggtacat 60
atcagagtca ccatcacttg ccgggcaagt cagagcatta gcagctattt aaattggtat 120
cagcagaaac cagggaaagc ccctaagctc ctgatctatg ctgcatccag tttgcaaagt 180
ggggtcccat caaggttcag tggcagtgga tctgggacag atttcactct caccatcagc 240
agtctgcaac ctgaagattt tgcaacttat tactgtcagt gtggttacag tacacctccg 300
tggacgttcg gccaagggac caaggtggaa atcaaacgcg tatacatgca tgctactgtg 360
gctgcaccat ctgtcttcat cttcc 385
<210> 118
<211> 400
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 118
gatattgtga tgactcagtc tccactctcc ctgcccgtca cccctggaga gcgtgtacaa 60
ctgccggcct ccatctcctg caggtctagt cagagcctcc tgcatagtaa tggatacaac 120
tatttggatt ggtacctgca gaagccaggg cagtctccac agctcctgat ctatttgggt 180
tctaatcggg cctccggggt ccctgacagg ttcagtggca gtggatcagg cacagatttt 240
acactgaaaa tcagcagagt ggaggctgag gatgttgggg tttattactg catgcaagct 300
ctacaaactc ctccgctcac tttcggcgga gggaccaagg tggagatcaa acaaaccctt 360
tgggatgcta ctgtggctgc accatctgtc ttcatcttcc 400
<210> 119
<211> 400
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 119
gatgttgtga tgactcagtc tccactctcc ctgcccgtca cccttggaca tgagcgcaat 60
tcgccggcct ccatctcctg caggtctagt caaagcctcg tacacagtga tggaaacacc 120
tacttgaatt ggtttcagca gaggccaggc caatctccaa ggcgcctaat ttataaggtt 180
tctaaccggg actctggggt cccagacaga ttcagcggca gtgggtcagg cactgatttc 240
acactgaaaa tcagcagggt ggaggctgag gatgttgggg tttattactg catgcaaggt 300
acacactggc ctccattcac tttcggccct gggaccaaag tggatatcaa actaacgcta 360
tcggatgcta ctgtggctgc accatctgtc ttcatcttcc 400
<210> 120
<211> 397
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 120
gacattgtgc tgacccagtc tccagcctcc ttggccgtgt ctccaggaca taacggtcgt 60
cagagggcca ccatcacctg cagagccagt gagagtgtca gtttcttggg aataaactta 120
attcactggt atcagcagaa accaggacaa cctcctaaac tcctgattta ccaagcatcc 180
aataaagaca ctggggtccc agccaggttc agcggcagtg ggtctgggac cgatttcacc 240
ctcacaatta atcctgtgga agctaatgat actgcaaatt attactgtct gcagagtaag 300
aattttcctc cgtggacgtt cggccaaggg accaaggtgg aaatcaaaca tcaagcgtct 360
gatgctactg tggctgcacc atctgtcttc atcttcc 397
<210> 121
<211> 388
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 121
gaaattgtgt tgacgcagtc tccaggcacc ctgtctttgt ctccagggga ccgaatgcga 60
ttaagagcca ccctctcctg cagggccagt cagagtgtta gcagcagcta cttagcctgg 120
taccagcaga aacctggcca ggctcccagg ctcctcatct atggtgcatc cagcagggcc 180
actggcatcc cagacaggtt cagtggcagt gggtctggga cagacttcac tctcaccatc 240
agcagactgg agcctgaaga ttttgcagtg tattactgtc agcagtatgg tagctcacct 300
ccattcactt tcggccctgg gaccaaagtg gatatcaaac gtcgacagta ctatgctact 360
gtggctgcac catctgtctt catcttcc 388
<210> 122
<211> 385
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 122
gacatccaga tgacccagtc tccatccttc ctgtctgcat ctgtaggaga ccgaacatgg 60
ttcagagtca ccatcacttg ccgggcaagt cagagcatta gcagctattt aaattggtat 120
cagcagaaac cagggaaagc ccctaagctc ctgatctatg ctgcatccag tttgcaaagt 180
ggggtcccat caaggttcag tggcagtgga tctgggacag atttcactct caccatcagc 240
agtctgcaac ctgaagattt tgcaacttat tactgtcagt gtggttacag tacacctccg 300
tgcacttttg gccaggggac caagctggag atcaaacacg cttggtacaa tgctactgtg 360
gctgcaccat ctgtcttcat cttcc 385
<210> 123
<211> 385
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 123
gacatccagt tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga tcagctcata 60
ggcagagtca ccatcacttg ccgggtgagt cagggcatta gcagttattt aaattggtat 120
cggcagaaac cagggaaagt tcctaagctc ctgatctata gtgcatccaa tttgcaatct 180
ggagtcccat ctcggttcag tggcagtgga tctgggacag atttcactct cactatcagc 240
agcctgcagc ctgaagatgt tgcaacttat tacggtcaac ggacttacaa tgcccctccg 300
ctcactttcg gcggagggac caaggtggag atcaaactcg catcagagta tgctactgtg 360
gctgcaccat ctgtcttcat cttcc 385
<210> 124
<211> 369
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 124
gaaattgtgt tgacacagtc tccagccacc ctgtctttgt ctccagggga gatatctacg 60
gcaagagcca ccctctcctg cagggccagt cagagtgtta gcagcagcta cttagcctgg 120
taccagcaga aacctggcca ggctcccagg ctcctcatct atggtgcatc cagcagggcc 180
actggcatcc cagcaaggtt cagtggcagt gggtctggga cagacttcac tctcaccatc 240
agcagactgg agcctgaaga ttttgcagtt tattactgtc agcgtgcact tttggccagg 300
ggaccaagct ggagatcaaa cgttaccgca tgaatgctac tgtggctgca ccatctgtct 360
tcatcttcc 369
<210> 125
<211> 400
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 125
gatattgtga tgactcagtc tccactctcc ctgcccgtca cccctggaga taggtcccgt 60
aagccggcct ccatctcctg caggtctagt cagagcctcc tgcatagtaa tggatacaac 120
tatttggatt ggtacctgca gaagccaggg cagtctccac agctcctgat ctatttgggt 180
tctaatcggg cctccggggt ccctgacagg ttcagtggca gtggatcagg cacagatttt 240
acactgaaaa tcagcagagt ggaggctgag gatgttgggg tttattactg catgcaagct 300
ctacaaactc ctccgatcac cttcggccaa gggacacgac tggagattaa actactgacc 360
gtgaatgcta ctgtggctgc accatctgtc ttcatcttcc 400
<210> 126
<211> 385
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 126
gccatccaga tgacccagtc tccatcctcc ctgtctgcat ctgttggaga attaccgacg 60
tgcagagtca ccatcacttg ccgggcaagt cagggcatta gaaatgattt aggctggtat 120
cagcagaaac cagggaaagc ccctaagctc ctgatctatg ctgcatccag tttacaaagt 180
ggggtcccat caaggttcag cggcagtgga tctggcacag atttcactct caccatcagc 240
agcctgcagc ctgaagattt tgcaacttat tactgtctac aagattacaa ttaccctccg 300
tggacgttcg gccaagggac caaggtggaa atcaaaccct cttaagagga tgctactgtg 360
gctgcaccat ctgtcttcat cttcc 385
<210> 127
<211> 385
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 127
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga tcgcggtcat 60
aacagagtca ccatcacttg ccgggcgagt cagggcatta gcaattattt agcctggtat 120
cagcagaaac cagggaaagt tcctaagctc ctgatctatg ctgcatccac tttgcaatca 180
ggggtcccat ctcggttcag tggcagtgga tctgggacag atttcactct caccatcagc 240
agcctgcagc ctgaagatgt tgcaacttat tactgtcaaa agtataacag tgcccctccg 300
ctcacgttcg gcggagggac caaggtggag atcaaactat caccgtagga tgctactgtg 360
gctgcaccat ctgtcttcat cttcc 385
<210> 128
<211> 403
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 128
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga tgctcgaagc 60
tagagggcca ccatcaactg caagtccagc cagagtgttt tatacagctc caacaataag 120
aactacttag cttggtacca gcagaaacca ggacagcctc ctaagctgct catttactgg 180
gcatctaccc gggaatccgg ggtccctgac cgattcagtg gcagcgggtc tgggacagat 240
ttcactctca ccatcagcag cctgcaggct gaagatgtgg cagtttatta ctgtcagcaa 300
tattatagta ctcctccgtg gacgttcggc caagggacca aggtggaaat caaaccttag 360
ccgaatgatg ctactgtggc tgcaccatct gtcttcatct tcc 403
<210> 129
<211> 385
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 129
gccatccagt tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ctaacaggct 60
tgcagagtca ccatcacttg ccgggcaagt cagggcatta gcagtgcttt agcctggtat 120
cagcagaaac cagggaaagc tcctaagctc ctgatctatg atgcctccag tttggaaagt 180
ggggtcccat caaggttcag cggcagtgga tctgggacag atttcactct caccatcagc 240
agcctgcagc ctgaagattt tgcaacttat tactgtcaac agtttaatag ttaccctcag 300
ctcacgttcg gcggagggac caaggtggag atcaaacaga taggccttca tgctactgtg 360
gctgcaccat ctgtcttcat cttcc 385
<210> 130
<211> 385
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 130
gaaattgtgc tgactcagtc tccagacttt cagtctgtga ctccaaagga cacggatagc 60
ttgaaagtca ccatcacctg ccgggccagt cagagcattg gtagtagctt acactggtac 120
cagcagaaac cagatcagtc tccaaagctc ctcatcaagt atgcttccca gtccttctca 180
ggggtcccct cgaggttcag tggcagtgga tctgggacag atttcaccct caccatcaat 240
agcctggaag ctgaagatgc tgcaacgtat tactgtcatc agagtagtag tttacctcag 300
tggacgttcg gccaagggac caaggtggaa atcaaacgcc taagagtcta tgctactgtg 360
gctgcaccat ctgtcttcat cttcc 385
<210> 131
<211> 385
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 131
gaaatagtga tgacgcagtc tccagccacc ctgtctgtgt ctccagggga cagaatttcg 60
gcaagagcca ccctctcctg cagggccagt cagagtgtta gcagcaactt agcctggtac 120
cagcagaaac ctggccaggc tcccaggctc ctcatctatg gtgcatccac cagggccact 180
ggtatcccag ccaggttcag tggcagtggg tctgggacag agttcactct caccatcagc 240
agcctgcagt ctgaagattt tgcagtttat tactgtcagc agtataataa ctggcctccg 300
ctcacgttcg gcggagggac caaggtggag atcaaacggg ctttaaccaa tgctactgtg 360
gctgcaccat ctgtcttcat cttcc 385
<210> 132
<211> 385
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 132
gaaattgtgt tgacacagtc tccagccacc ctgtctttgt ctccagggga gagaactctc 60
gtaagagcca ccctctcctg cagggccagt cagagtgtta gcagctactt agcctggtac 120
caacagaaac ctggccaggc tcccaggctc ctcatctatg atgcatccaa cagggccact 180
ggcatcccag ccaggttcag tggcagtggg tctgggagag acttcactct caccatcagc 240
agcctagagc ctgaagattt tgcagtttat tactgtcagc agcgtagcaa ctggcctccg 300
ctcactttcg gcggagggac caaggtggag atcaaacagt agcgcactta tgctactgtg 360
gctgcaccat ctgtcttcat cttcc 385
<210> 133
<211> 370
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 133
gaaattgtgt tgacacagtc tccagccacc ctgtctttgt ctccagggga ggtgaaactt 60
ccaagagcca ccctctcctg cagggccagt cagagtgtta gcagcagcta cttagcctgg 120
taccagcaga aacctggcca ggctcccagg ctcctcatct atggtgcatc cagcagggcc 180
actggcatcc cagcaaggtt cagtggcagt gggtctggga cagacttcac tctcaccatc 240
agcagactgg agcctgaaga ttttgcagtt tattactgtc agctgtacac ttttggccag 300
gggaccaagc tggagatcaa acgctgcaaa tcgtatgcta ctgtggctgc accatctgtc 360
ttcatcttcc 370
<210> 134
<211> 385
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 134
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgttgaaga 60
tccagagtca ccatcacttg ccgggcaagt cagggcatta gaaatgattt aggctggtat 120
cagcagaaac cagggaaagc ccctaagcgc ctgatctatg ctgcatccag tttgcaaagt 180
ggggtcccat caaggttcag cggcagtgga tctgggacag aattcactct cacaatcagc 240
agcctgcagc ctgaagattt tgcaacttat tactgtctac agcataatag ttaccctcca 300
ttcactttcg gccctgggac caaagtggat atcaaaccac cgtgtaagta tgctactgtg 360
gctgcaccat ctgtcttcat cttcc 385
<210> 135
<211> 400
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 135
gatattgtga tgacccagac tccactctct ctgtccgtca cccctggaca agtctcacag 60
gtgccggcct ccatctcctg caagtctagt cagagcctcc tgcatagtga tggaaagacc 120
tatttgtatt ggtacctgca gaagccaggc cagtctccac agctcctgat ctatgaagtt 180
tccagccggt tctctggagt gccagatagg ttcagtggca gcgggtcagg gacagatttc 240
acactgaaaa tcagccgggt ggaggctgag gatgttgggg tttattactg aatgcaaggt 300
atacaccttc ctccgctcac gttcggcgga gggaccaagg tggagatcaa accttacggg 360
aatcatgcta ctgtggctgc accatctgtc ttcatcttcc 400
<210> 136
<211> 388
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 136
gaaattgtgt tgacgcagtc tccaggcacc ctgtctttgt ctccagggga ttaggccacg 60
taaagagcca ccctctcctg cagggccagt cagagtgtta gcagcagcta cttagcctgg 120
taccagcaga aacctggcca ggctcccagg ctcctcatct atggtgcatc cagcagggcc 180
actggcatcc cagacaggtt cagtggcagt gggtctggga cagacttcac tctcaccatc 240
agcagactgg agcctgaaga ttttgcagtg tattactgtc agcagtatgg tagctcacct 300
ccgctcactt tcggcggagg gaccaaggtg gagatcaaac accttgtaag cgatgctact 360
gtggctgcac catctgtctt catcttcc 388
<210> 137
<211> 385
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 137
gaaattgtgt tgacacagtc tccagccacc ctgtctttgt ctccagggga tttgccagaa 60
cgaagagcca ccctctcctg cagggccagt cagagtgtta gcagctactt agcctggtac 120
caacagaaac ctggccaggc tcccaggctc ctcatctatg atgcatccaa cagggccact 180
ggcatcccag ccaggttcag tggcagtggg tctgggacag acttcactct caccatcagc 240
agcctagagc ctgaagattt tgcagtttat tactgtcagc agcgtagcaa ctggcctccg 300
atcaccttcg gccaagggac acgactggag attaaactac cgtatagcga tgctactgtg 360
gctgcaccat ctgtcttcat cttcc 385
<210> 138
<211> 385
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 138
gacatccaga tgacccagtc tccatcttcc gtgtctgcat ctgtaggaga ctagaactgc 60
tgcagagtca ccatcacttg tcgggcgagt cagggtatta gcagctggtt agcctggtat 120
cagcagaaac cagggaaagc ccctaagctc ctgatctatg ctgcatccag tttgcaaagt 180
ggggtcccat caaggttcag cggcagtgga tctgggacag atttcactct caccatcagc 240
agcctgcagc ctgaagattt tgcaacttac tattgtcaac aggctaacag tttcccttcg 300
ctcacgttcg gcggagggac caaggtggag atcaaactgc taacgagtca tgctactgtg 360
gctgcaccat ctgtcttcat cttcc 385
<210> 139
<211> 385
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 139
gccatccaga tgacccagtc tccatcctcc ctgtctgcat ctgttggaga gaattcggta 60
cccagagtca ccatcacttg ccgggcaagt cagggcatta gaaatgattt aggctggtat 120
cagcagaaac cagggaaagc ccctaagctc ctgatctatg ctgcatccag tttacaaagt 180
ggggtcccat caaggttcag cggcagtgga tctggcacag atttcactct caccatcagc 240
agcctgcagc ctgaagattt tgcaacttat tactgtctac aagattacaa ttaccctccg 300
tgcacttttg gccaggggac caagctggag atcaaacagc cgcattgtaa tgctactgtg 360
gctgcaccat ctgtcttcat cttcc 385
<210> 140
<211> 385
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 140
gacatccaga tgacccagtc tccatcctca ctgtctgcat ctgtaggaga ggtaatcgcc 60
atcagagtca ccatcacttg tcgggcgagt cagggcatta gcaattattt agcctggttt 120
cagcagaaac cagggaaagc ccctaagtcc ctgatctatg ctgcatccag tttgcaaagt 180
ggggtcccat caaggttcag cggcagtgga tctgggacag atttcactct caccatcagc 240
agcctgcagc ctgaagattt tgcaacttat tactgccaac agtataatag ttaccctccg 300
ctcacgttcg gcggagggac caaggtggag atcaaacgct taaagctcga tgctactgtg 360
gctgcaccat ctgtcttcat cttcc 385
<210> 141
<211> 385
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 141
gacatccaga tgacccagtc tccatctgcc atgtctgcat ctgtaggaga gactcggttc 60
aacagagtca ccatcacttg tcgggcgagt cagggcatta gcaattattt agcctggttt 120
cagcagaaac cagggaaagt ccctaagcgc ctgatctatg ctgcatccag tttgcaaagt 180
ggggtcccat caaggttcag cggcagtgga tctgggacag aattcactct cacaatcagc 240
agcctgcagc ctgaagattt tgcaacttat tactgtctac agcataatag ttaccctccg 300
ctcacgttcg gcggagggac caaggtggag atcaaacaga gcgtattcca tgctactgtg 360
gctgcaccat ctgtcttcat cttcc 385
<210> 142
<211> 385
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 142
gacatccaga tgacccagtc tccatctgcc atgtctgcat ctgtaggaga tcgcaagacg 60
ttcagagtca ccatcacttg tcgggcgagt cagggcatta gcaattattt agcctggttt 120
cagcagaaac cagggaaagt ccctaagcgc ctgatctatg ctgcatccag tttgcaaagt 180
ggggtcccat caaggttcag cggcagtgga tctgggacag aattcactct cacaatcagc 240
agcctgcagc ctgaagattt tgcaacttat tactgtctac agcataatag ttaccctccg 300
tggacgttcg gccaagggac caaggtggaa atcaaacacc gaactgtgta tgctactgtg 360
gctgcaccat ctgtcttcat cttcc 385
<210> 143
<211> 403
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 143
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga tcacgttcga 60
aggagggcca ccatcaactg caagtccagc cagagtgttt tatacagctc caacaataag 120
aactacttag cttggtacca gcagaaacca ggacagcctc ctaagctgct catttactgg 180
gcatctaccc gggaatccgg ggtccctgac cgattcagtg gcagcgggtc tgggacagat 240
ttcactctca ccatcagcag cctgcaggct gaagatgtgg cagtttatta ctgtcagcaa 300
tattatagta ctcctccgct cacgttcggc ggagggacca aggtggagat caaaccggga 360
cctatatatg ctactgtggc tgcaccatct gtcttcatct tcc 403
<210> 144
<211> 385
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 144
gacatccaga tgacccagtc tccttccacc ctgtctgcat ctgtaggaga tactacgctg 60
gacagagtca ccatcacttg ccgggccagt cagagtatta gtagctggtt ggcctggtat 120
cagcagaaac cagggaaagc ccctaagctc ctgatctatg atgcctccag tttggaaagt 180
ggggtcccat caaggttcag cggcagtgga tctgggacag aattcactct caccatcagc 240
agcctgcagc ctgatgattt tgcaacttat tactgccaac agtataatag ttattctccg 300
ctcactttcg gcggagggac caaggtggag atcaaacgta accgagtcta tgctactgtg 360
gctgcaccat ctgtcttcat cttcc 385
<210> 145
<211> 400
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 145
gatgttgtga tgactcagtc tccactctcc ctgcccgtca cccttggaca aggcttagac 60
ctgccggcct ccatctcctg caggtctagt caaagcctcg tacacagtga tggaaacacc 120
tacttgaatt ggtttcagca gaggccaggc caatctccaa ggcgcctaat ttataaggtt 180
tctaaccggg actctggggt cccagacaga ttcagcggca gtgggtcagg cactgatttc 240
acactgaaaa tcagcagggt ggaggctgag gatgttgggg tttattactg catgcaaggt 300
acacactggc ctccgctcac tttcggcgga gggaccaagg tggagatcaa actcgatcga 360
agtcatgcta ctgtggctgc accatctgtc ttcatcttcc 400
<210> 146
<211> 385
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 146
gacatccaga tgacccagtc tccttccacc ctgtctgcat ctgtaggaga gggaatactc 60
ctcagagtca ccatcatttg ccgggccagt cagagtatta gtagctggtt ggcctggtat 120
cagcagaaac cagggaaagc ccctaagctc ctgatctatg atgcctccag tttggaaagt 180
ggggtcccat caaggttcag cggcagtgga tctgggacag aattcactct caccatcagc 240
agcctgcagc ctgatgattt tgcaacttat tactgccaac agtataatag ttattctccg 300
atcaccttcg gccaagggac acgactggag attaaaccga tttcgcgaaa tgctactgtg 360
gctgcaccat ctgtcttcat cttcc 385
<210> 147
<211> 385
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 147
gacatccaga tgacccagtc tccttccacc ctgtctgcat ctgtaggaga aaggcgcctt 60
tacagagtca ccatcacttg ccgggccagt cagagtatta gtagctggtt ggcctggtat 120
cagcagaaac cagggaaagc ccctaagctc ctgatctatg atgcctccag tttggaaagt 180
ggggtcccat caaggttcag cggcagtgga tctgggacag aattcactct caccatcagc 240
agcctgcagc ctgatgattt tgcaacttat tactgccaac agtataatag ttattctccg 300
atcaccttcg gccaagggac acgactggag attaaacgac tgtagtccaa tgctactgtg 360
gctgcaccat ctgtcttcat cttcc 385
<210> 148
<211> 385
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 148
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga gctagcactg 60
tacagagtca ccatcacttg ccgggcaagt cagggcatta gaaatgattt aggctggtat 120
cagcagaaac cagggaaagc ccctaagcgc ctgatctatg ctgcatccag tttgcaaagt 180
ggggtcccat caaggttcag cggcagtgga tctgggacag aattcactct cacaatcagc 240
agcctgcagc ctgaagattt tgcaacttat tactgtctac agcataatag ttaccctccg 300
tggacgttcg gccaagggac caaggtggaa atcaaactat gcctaagcga tgctactgtg 360
gctgcaccat ctgtcttcat cttcc 385
<210> 149
<211> 385
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 149
gacatccaga tgacccagtc tccatcctca ctgtctgcat ctgtaggaga taacgcggtc 60
tacagagtca ccatcacttg tcgggcgagt cagggcatta gcaattattt agcctggttt 120
cagcagaaac cagggaaagc ccctaagtcc ctgatctatg ctgcatccag tttgcaaagt 180
ggggtcccat caaggttcag cggcagtgga tctgggacag atttcactct caccatcagc 240
agcctgcagc ctgaagattt tgcaacttat tactgccaac agtataatag ttaccctccg 300
tggacgttcg gccaagggac caaggtggaa atcaaacttt cgagcgcaaa tgctactgtg 360
gctgcaccat ctgtcttcat cttcc 385
<210> 150
<211> 385
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 150
gccatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ctggaccaga 60
ttcagagtca ccatcacttg ccgggcaagt cagggcatta gaaatgattt aggctggtat 120
cagcagaaac cagggaaagc ccctaagctc ctgatctatg ctgcatccag tttacaaagt 180
ggggtcccat caaggttcag cggcagtgga tctggcacag atttcactct caccatcagc 240
agcctgcagc ctgaagattt tgcaacttat tactgtctac aagattacaa ttaccctccg 300
tggacgttcg gccaagggac caaggtggaa atcaaacagt ctccgtgaaa tgctactgtg 360
gctgcaccat ctgtcttcat cttcc 385
<210> 151
<211> 385
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 151
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga tgcagaaccg 60
ttcagagtca ccatcacttg ccgggcgagt cagggcatta gcaattcttt agcctggtat 120
cagcagaaac cagggaaagc ccctaagctc ctgctctatg ctgcatccag attggaaagt 180
ggggtcccat ccaggttcag tggcagtgga tctgggacgg attacactct caccatcagc 240
agcctgcagc ctgaagattt tgcaacttat tactgtcaac agtattatag tacccctcca 300
ttcactttcg gccctgggac caaagtggat atcaaacccg acttatagga tgctactgtg 360
gctgcaccat ctgtcttcat cttcc 385
<210> 152
<211> 369
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 152
gaaattgtgt tgacacagtc tccagccacc ctgtctttgt ctccagggga tcgaatcacg 60
tgaagagcca ccctctcctg cagggccagt cagagtgtta gcagcagcta cttagcctgg 120
taccagcaga aacctggcca ggctcccagg ctcctcatct atggtgcatc cagcagggcc 180
actggcatcc cagcaaggtt cagtggcagt gggtctggga cagacttcac tctcaccatc 240
agcagactgg agcctgaaga ttttgcagtt tattactgtc agcgtggacg ttcggccaag 300
ggaccaaggt ggaaatcaaa ctcgatcaat gcgatgctac tgtggctgca ccatctgtct 360
tcatcttcc 369
<210> 153
<211> 385
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 153
gacatccaga tgacccagtc tccatccttc ctgtctgcat ctgtaggaga aatctacgcg 60
tgcagagtca ccatcacttg ccgggcaagt cagagcatta gcagctattt aaattggtat 120
cagcagaaac cagggaaagc ccctaagctc ctgatctatg ctgcatccag tttgcaaagt 180
ggggtcccat caaggttcag tggcagtgga tctgggacag atttcactct caccatcagc 240
agtctgcaac ctgaagattt tgcaacttat tactgtcagt gtggttacag tacacctccg 300
ctcacgttcg gcggagggac caaggtggag atcaaacagc ggcaattcta tgctactgtg 360
gctgcaccat ctgtcttcat cttcc 385
<210> 154
<211> 349
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 154
gcctccatct cctgcaggtc tagtcagagc ctcttggata gtgatgatgg ctgtctcaaa 60
ggaaacacct atttggattg ttacctgcag aagccagggc agtctccaca gctcctgatc 120
tatacgcttt cctatcgggc ctctggagtc ccagacaggt tcagtgacag tgggtcaggc 180
actgatttca cactgaaaat cagcagggtg gaggctgagg atgttggagt ttattactgc 240
atgcaacgta tagagtttcc ttcattcact ttcggccctg ggaccaaagt ggatatcaaa 300
cagcacttag tcgatgctac tgtggctgca ccatctgtct tcatcttcc 349
<210> 155
<211> 400
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 155
gatattgtga tgacccagac tccactctct ctgtccgtca cccctggaca tcggcatacg 60
tagccggcct ccatctcctg caagtctagt cagagcctcc tgcatagtga tggaaagacc 120
tatttgtatt ggtacctgca gaagccaggc cagtctccac agctcctgat ctatgaagtt 180
tccagccggt tctctggagt gccagatagg ttcagtggca gcgggtcagg gacagatttc 240
acactgaaaa tcagccgggt ggaggctgag gatgttgggg tttattactg aatgcaaggt 300
atacaccttc ctccgtggac gttcggccaa gggaccaagg tggaaatcaa acctggcatc 360
tgaaatgcta ctgtggctgc accatctgtc ttcatcttcc 400
<210> 156
<211> 400
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 156
gatattgtga tgacccagac tccactctcc tcacctgtca cccttggaca tgtcacatag 60
gcgccggcct ccatctcctg caggtctagt caaagcctcg tacacagtga tggaaacacc 120
tacttgagtt ggcttcagca gaggccaggc cagcctccaa gactcctaat ttataagatt 180
tctaaccggt tctctggggt cccagacaga ttcagtggca gtggggcagg gacagatttc 240
acactgaaaa tcagcagggt ggaagctgag gatgtcgggg tttattactg catgcaagct 300
acacaatttc ctcagtggac gttcggccaa gggaccaagg tggaaatcaa accgaacgtc 360
tatgatgcta ctgtggctgc accatctgtc ttcatcttcc 400
<210> 157
<211> 385
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 157
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga aagcgtcgca 60
ttcagagtca ccatcacttg ccgggcaagt cagggcatta gaaatgattt aggctggtat 120
cagcagaaac cagggaaagc ccctaagcgc ctgatctatg ctgcatccag tttgcaaagt 180
ggggtcccat caaggttcag cggcagtgga tctgggacag aattcactct cacaatcagc 240
agcctgcagc ctgaagattt tgcaacttat tactgtctac agcataatag ttaccctccg 300
ctcactttcg gcggagggac caaggtggag atcaaacgtt acccgtaaga tgctactgtg 360
gctgcaccat ctgtcttcat cttcc 385
<210> 158
<211> 349
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 158
gcctccatct cctgcaggtc tagtcagagc ctcttggata gtgatgatgg accgaggtac 60
ttaaacacct atttggattg ttacctgcag aagccagggc agtctccaca gctcctgatc 120
tatacgcttt cctatcgggc ctctggagtc ccagacaggt tcagtgacag tgggtcaggc 180
actgatttca cactgaaaat cagcagggtg gaggctgagg atgttggagt ttattactgc 240
atgcaacgta tagagtttcc ttcgtgcact tttggccagg ggaccaagct ggagatcaaa 300
ctcgaccatt aggatgctac tgtggctgca ccatctgtct tcatcttcc 349
<210> 159
<211> 349
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 159
gcctccatct cctgcaggtc tagtcagagc ctcttggata gtgatgatgg aacgggtctc 60
taaaacacct atttggattg ttacctgcag aagccagggc agtctccaca gctcctgatc 120
tatacgcttt cctatcgggc ctctggagtc ccagacaggt tcagtgacag tgggtcaggc 180
actgatttca cactgaaaat cagcagggtg gaggctgagg atgttggagt ttattactgc 240
atgcaacgta tagagtttcc ttcgctcacg ttcggcggag ggaccaaggt ggagatcaaa 300
cgatacgcgc ttaatgctac tgtggctgca ccatctgtct tcatcttcc 349
<210> 160
<211> 385
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 160
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga gggcacaatt 60
tccagagtca ccatcacttg ccaggcgagt caggacatta gcaactattt aaattggtat 120
cagcagaaac cagggaaagc ccctaagctc ctgatctacg atgcatccaa tttggaaaca 180
ggggtcccat caaggttcag tggaagtgga tctgggacag attttacttt caccatcagc 240
agcctgcagc ctgaagatat tgcaacatat tactgtcaac agtatgataa tctccctcca 300
ttcactttcg gccctgggac caaagtggat atcaaacgtt caagagccta tgctactgtg 360
gctgcaccat ctgtcttcat cttcc 385
<210> 161
<211> 388
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 161
gaaattgtaa tgacacagtc tccacccacc ctgtctttgt ctccagggga tcacgtagga 60
ctaagagtca ccctctcctg cagggccagt cagagtgtta gcagcagcta cttaacctgg 120
tatcagcaga aacctggcca ggcgcccagg ctcctcatct atggtgcatc caccagggcc 180
actagcatcc cagccaggtt cagtggcagt gggtctggga cagacttcac tctcaccatc 240
agcagcctgc agcctgaaga ttttgcagtt tattactgtc agcaggatca taacttacct 300
ccgctcactt tcggcggagg gaccaaggtg gagatcaaac cctaggctat agatgctact 360
gtggctgcac catctgtctt catcttcc 388
<210> 162
<211> 388
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 162
gaaattgtaa tgacacagtc tccacccacc ctgtctttgt ctccagggga atgccacggt 60
taaagagtca ccctctcctg cagggccagt cagagtgtta gcagcagcta cttaacctgg 120
tatcagcaga aacctggcca ggcgcccagg ctcctcatct atggtgcatc caccagggcc 180
actagcatcc cagccaggtt cagtggcagt gggtctggga gagacttcac tctcaccatc 240
agcagcctgc agcctgaaga ttttgcagtt tattactgtc agcaggatca taacttacct 300
ccgctcactt tcggcggagg gaccaaggtg gagatcaaac atgcatagcc gtatgctact 360
gtggctgcac catctgtctt catcttcc 388
<210> 163
<211> 385
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 163
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga atcacggcgt 60
tacagagtca ccatcacttg ccgggcgagt cagggcatta gcaattattt agcctggtat 120
cagcagaaac cagggaaagt tcctaagctc ctgatctatg ctgcatccac tttgcaatca 180
ggggtcccat ctcggttcag tggcagtgga tctgggacag atttcactct caccatcagc 240
agcctgcagc ctgaagatgt tgcaacttat tactgtcaaa agtataacag tgcccctccg 300
tggacgttcg gccaagggac caaggtggaa atcaaacgct tacaggctaa tgctactgtg 360
gctgcaccat ctgtcttcat cttcc 385
<210> 164
<211> 400
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 164
gatattgtga tgacccagac tccactctct ctgtccgtca cccctggaca ttctgccaag 60
aggccggcct ccatctcctg caagtctagt cagagcctcc tgcatagtga tggaaagacc 120
tatttgtatt ggtacctgca gaagccaggc cagtctccac agctcctgat ctatgaagtt 180
tccagccggt tctctggagt gccagatagg ttcagtggca gcgggtcagg gacagatttc 240
acactgaaaa tcagccgggt ggaggctgag gatgttgggg tttattactg catgcaaggt 300
atacaccttc ctccgctcac gttcggcgga gggaccaagg tggagatcaa acacggcttg 360
tcaaatgcta ctgtggctgc accatctgtc ttcatcttcc 400
<210> 165
<211> 385
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 165
gacatccagt tgacccagtc tccatccttc ctgtctgcat ctgtaggaga ctcggaaatc 60
tgcagagtca ccatcacttg ccgggccagt cagggcatta gcagttattt agcctggtat 120
cagcaaaaac cagggaaagc ccctaagctc ctgatctatg ctgcatccac tttgcaaagt 180
ggggtcccat caaggttcag cggcagtgga tctgggacag aattcactct cacaatcagc 240
agcctgcagc ctgaagattt tgcaacttat tactgtcaac agcttaatag ttaccctccg 300
tggacgttcg gccaagggac caaggtggaa atcaaaccgt tcgaaagcta tgctactgtg 360
gctgcaccat ctgtcttcat cttcc 385
<210> 166
<211> 385
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 166
gaaatagtga tgacgcagtc tccagccacc ctgtctgtgt ctccagggga taagggccac 60
ttaagagcca ccctctcctg cagggccagt cagagtgtta gcagcaactt agcctggtac 120
cagcagaaac ctggccaggc tcccaggctc ctcatctatg gtgcatccac cagggccact 180
ggtatcccag ccaggttcag tggcagtggg tctgggacag agttcactct caccatcagc 240
agcctgcagt ctgaagattt tgcagtttat tactgtcagc agtataataa ctggcctccg 300
ctcactttcg gcggagggac caaggtggag atcaaacggt tacccgataa tgctactgtg 360
gctgcaccat ctgtcttcat cttcc 385
<210> 167
<211> 400
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 167
gatattgtga tgacccagac tccaccctcc ctgcccgtca accctggaga ttatcggaac 60
cggccggcct ccatctcttg caggtctagt cagagcctcc tgcatagtaa tggatatacc 120
tatttgcatt ggtacctgca gaagccaggg cagtctccac agctcctgat ttatagggtt 180
tccaatcatc tttctggggt cccagacagg tttagtggca gtgggtcagg tagtgatttc 240
acactgaaaa tcagctgggt ggaggctgag gatgttgggg tttattactg catgcaagct 300
acacagtttc ctaagctcac tttcggcgga gggaccaagg tggagatcaa acgcgcagta 360
tactatgcta ctgtggctgc accatctgtc ttcatcttcc 400
<210> 168
<211> 385
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 168
gacatccaga tgacccagtc tccatcttcc gtgtctgcat ctgtaggaga ttcgcagcaa 60
tgcagagtca ccatcacttg tcgggcgagt cagggtatta gcagctggtt agcctggtat 120
cagcagaaac cagggaaagc ccctaagctc ctgatctatg ctgcatccag tttgcaaagt 180
ggggtcccat caaggttcag cggcagtgga tctgggacag atttcactct caccatcagc 240
agcctgcagc ctgaagattt tgcaacttac tattgtcaac aggctaacag tttccctccg 300
tggacgttcg gccaagggac caaggtggaa atcaaaccca agcttgtaga tgctactgtg 360
gctgcaccat ctgtcttcat cttcc 385
<210> 169
<211> 388
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 169
gaaattgtaa tgacacagtc tccacccacc ctgtctttgt ctccagggga tctacgcgga 60
taaagagtca ccctctcctg cagggccagt cagagtgtta gcagcagcta cttaacctgg 120
tatcagcaga aacctggcca ggcgcccagg ctcctcatct atggtgcatc caccagggcc 180
actagcatcc cagccaggtt cagtggcagt gggtctggga cagacttcac tctcaccatc 240
agcagcctgc agcctgaaga ttttgcagtt tattactgtc agcaggatca taacttacct 300
ccgatcacct tcggccaagg gacacgactg gagattaaac gcggaactta ctatgctact 360
gtggctgcac catctgtctt catcttcc 388
<210> 170
<211> 401
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 170
gagattgtga tgacccagac tccactctcc ttgtctatca cccctggaga ctatagcagg 60
ctgcaggcct ccatgtcctg caggtctagt cagagcctcc tgcatagtga tggatacacc 120
tatttgtatt ggtttctgca gaaagccagg ccagtctcca cagctcctga tctatgaagt 180
ttccaaccgg ttctctggag tgccagatag gttcagtggc agcgggtcag ggacagattt 240
cacactgaaa atcagccggg tggaggctga ggatgttgga gtttattact gcatgcaaga 300
tgcacaagat cctccgctca cgttcggcgg agggaccaag gtggagatca aacctcgtaa 360
ggctaatgct actgtggctg caccatctgt cttcatcttc c 401
<210> 171
<211> 385
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 171
gacatccaga tgacccagtc tccttccacc ctgtctgcat ctgtaggaga gcaagtcttc 60
gacagagtca ccatcatttg ccgggccagt cagagtatta gtagctggtt ggcctggtat 120
cagcagaaac cagggaaagc ccctaagctc ctgatctatg atgcctccag tttggaaagt 180
ggggtcccat caaggttcag cggcagtgga tctgggacag aattcactct caccatcagc 240
agcctgcagc ctgatgattt tgcaacttat tactgccaac agtataatag ttattctccg 300
tggacgttcg gccaagggac caaggtggaa atcaaaccgg catttcagaa tgctactgtg 360
gctgcaccat ctgtcttcat cttcc 385
<210> 172
<211> 400
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 172
gatattgtga tgacccagac tccactctct ctgtccgtca cccctggaca gtaactatgg 60
ccgccggcct ccatctcctg caagtctagt cagagcctcc tgcatagtga tggaaagacc 120
tatttgtatt ggtacctgca gaagccaggc cagtctccac agctcctgat ctatgaagtt 180
tccagccggt tctctggagt gccagatagg ttcagtggca gcgggtcagg gacagatttc 240
acactgaaaa tcagccgggt ggaggctgag gatgttgggg tttattactg aatgcaaggt 300
atacaccttc ctccgtgcac ttttggccag gggaccaagc tggagatcaa actcctgcta 360
aaggatgcta ctgtggctgc accatctgtc ttcatcttcc 400
<210> 173
<211> 400
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 173
gatattgtga tgacccagac tccactctct ctgtccgtca cccctggaca gttcctgaaa 60
gcgccggcct ccatctcctg caagtctagt cagagcctcc tgcatagtga tggaaagacc 120
tatttgtatt ggtacctgca gaagccaggc cagtctccac agctcctgat ctatgaagtt 180
tccagccggt tctctggagt gccagatagg ttcagtggca gcgggtcagg gacagatttc 240
acactgaaaa tcagccgggt ggaggctgag gatgttgggg tttattactg catgcaaggt 300
atacaccttc ctccgtggac gttcggccaa gggaccaagg tggaaatcaa accccgggta 360
attaatgcta ctgtggctgc accatctgtc ttcatcttcc 400
<210> 174
<211> 400
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 174
gatattgtga tgactcagtc tccactctcc ctgcccgtca cccctggaga gcacgtgaat 60
tcgccggcct ccatctcctg caggtctagt cagagcctcc tgcatagtaa tggatacaac 120
tatttggatt ggtacctgca gaagccaggg cagtctccac agctcctgat ctatttgggt 180
tctaatcggg cctccggggt ccctgacagg ttcagtggca gtggatcagg cacagatttt 240
acactgaaaa tcagcagagt ggaggctgag gatgttgggg tttattactg catgcaagct 300
ctacaaactc ctccattcac tttcggccct gggaccaaag tggatatcaa acactcggta 360
cagtatgcta ctgtggctgc accatctgtc ttcatcttcc 400
<210> 175
<211> 385
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 175
gaaattgtgc tgactcagtc tccagacttt cagtctgtga ctccaaagga cagggtccaa 60
ttgaaagtca ccatcacctg ccgggccagt cagagcattg gtagtagctt acactggtac 120
cagcagaaac cagatcagtc tccaaagctc ctcatcaagt atgcttccca gtccatctca 180
ggggtcccct cgaggttcag tggcagtgga tctgggacag atttcaccct caccatcaat 240
agcctggaag ctgaagatgc tgcaacgtat tactgtcatc agagtagtag tttacctcag 300
atcaccttcg gccaagggac acgactggag attaaaccga acgttcagta tgctactgtg 360
gctgcaccat ctgtcttcat cttcc 385
<210> 176
<211> 385
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 176
gacatccaga tgacccagtc tccatcctca ctgtctgcat ctgtaggaga taagaccgtc 60
gtcagagtca ccatcacttg tcgggcgagt cagggcatta gcaattattt agcctggttt 120
cagcagaaac cagggaaagc ccctaagtcc ctgatctatg ctgcatccag tttgcaaagt 180
ggggtcccat caaggttcag cggcagtgga tctgggacag atttcactct caccatcagc 240
agcctgcagc ctgaagattt tgcaacttat tactgccaac agtataatag ttaccctcca 300
ttcactttcg gccctgggac caaagtggat atcaaaccct gtgcgtaaaa tgctactgtg 360
gctgcaccat ctgtcttcat cttcc 385
<210> 177
<211> 385
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 177
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cccggttaaa 60
gtcagagtca ccatcacttg ccgggcaagt cagggcatta gaaatgattt aggctggtat 120
cagcagaaac cagggaaagc ccctaagcgc ctgatctatg ctgcatccag tttgcaaagt 180
ggggtcccat caaggttcag cggcagtgga tctgggacag aattcactct cacaatcagc 240
agcctgcagc ctgaagattt tgcaacttat tactgtctac agcataatag ttaccctccg 300
tgcacttttg gccaggggac caagctggag atcaaacatg cacgctagta tgctactgtg 360
gctgcaccat ctgtcttcat cttcc 385
<210> 178
<211> 403
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 178
gatattgtga tgacccagac tccactctcc ctgcccgtca cccctggaga cttacggtac 60
gagccggcct ccatctcctg caggtctagt cagagcctct tggatagtga tgatggaaac 120
acctatttgg actggtacct gcagaagcca gggcagtctc cacagctcct gatctatacg 180
ctttcctatc gggcctctgg agtcccagac aggttcagtg gcagtgggtc aggcactgat 240
ttcacactga aaatcagcag ggtggaggct gaggatgttg gagtttatta ctgcatgcaa 300
cgtatagagt ttccttcatt cactttcggc cctgggacca aagtggatat caaactccaa 360
gtactggatg ctactgtggc tgcaccatct gtcttcatct tcc 403
<210> 179
<211> 385
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 179
gaaattgtgc tgactcagtc tccagacttt cagtctgtga ctccaaagga gttacctagc 60
gagaaagtca ccatcacctg ccgggccagt cagagcattg gtagtagctt acactggtac 120
cagcagaaac cagatcagtc tccaaagctc ctcatcaagt atgcttccca gtccttctca 180
ggggtcccct cgaggttcag tggcagtgga tctgggacag atttcaccct caccatcaat 240
agcctggaag ctgaagatgc tgcaacgtat tactgtcatc agagtagtag tttacctcaa 300
ttcactttcg gccctgggac caaagtggat atcaaacagg ttgccaatca tgctactgtg 360
gctgcaccat ctgtcttcat cttcc 385
<210> 180
<211> 385
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 180
gacatccaga tgacccagtc tccatcctca ctgtctgcat ctgtaggaga ttcgtacagc 60
gacagagtca ccatcacttg tcgggcgagt cagggcatta gcaattattt agcctggttt 120
cagcagaaac cagggaaagc ccctaagtcc ctgatctatg ctgcatccag tttgcaaagt 180
ggggtcccat caaagttcag cggcagtgga tctgggacag atttcactct caccatcagc 240
agcctgcagc ctgaagattt tgcaacttat tactgccaac agtataatag ttaccctccg 300
ctcactttcg gcggagggac caaggtggag atcaaacaag gcctacttga tgctactgtg 360
gctgcaccat ctgtcttcat cttcc 385
<210> 181
<211> 401
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 181
gagattgtga tgacccagac tccactctcc ttgtctatca cccctggaga ttacgcgcga 60
atgcaggcct ccatgtcctg caggtctagt cagagcctcc tgcatagtga tggatacacc 120
tatttgtatt ggtttctgca gaaagccagg ccagtctcca cagctcctga tctatgaagt 180
ttccaaccgg ttctctggag tgccagatag gttcagtggc agcgggtcag ggacagattt 240
cacactgaaa atcagccggg tggaggctga ggatgttgga gtttattact gcatgcaaga 300
tgcacaagat cctccgatca ccttcggcca agggacacga ctggagatta aacacgcgaa 360
ttgctatgct actgtggctg caccatctgt cttcatcttc c 401
<210> 182
<211> 400
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 182
gatgttgtga tgactcagtc tccactctcc ctgcccgtca cccttggaca aacgccttag 60
gtgccggcct ccatctcctg caggtctagt caaagcctcg tatacagtga tggaaacacc 120
tacttgaatt ggtttcagca gaggccaggc caatctccaa ggcgcctaat ttataaggtt 180
tctaaccggg actctggggt cccagacaga ttcagcggca gtgggtcagg cactgatttc 240
acactgaaaa tcagcagggt ggaggctgag gatgttgggg tttattactg catgcaaggt 300
acacactggc ctccgatcac cttcggccaa gggacacgac tggagattaa acttatcacg 360
ggcaatgcta ctgtggctgc accatctgtc ttcatcttcc 400
<210> 183
<211> 385
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 183
gacatccagt tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga aggagctcct 60
tacagagtca ccatcacttg ccgggtgagt cagggcatta gcagttattt aaattggtat 120
cggcagaaac cagggaaagt tcctaagctc ctgatctata gtgcatccaa tttgcaatct 180
ggagtcccat ctcggttcag tggcagtgga tctgggacag atttcactct cactatcagc 240
agcctgcagc ctgaagatgt tgcaacttat tacggtcaac ggacttacaa tgcccctccg 300
tggacgttcg gccaagggac caaggtggaa atcaaacccg agtaagttca tgctactgtg 360
gctgcaccat ctgtcttcat cttcc 385
<210> 184
<211> 385
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 184
gaaattgtgt tgacacagtc tccagccacc ctgtctttgt ctccagggga tgtcgccaga 60
ataagagcca ccctctcctg cagggccagt cagagtgtta gcagctactt agcctggtac 120
caacagaaac ctggccaggc tcccaggctc ctcatctatg atgcatccaa cagggccact 180
ggcatcccag ccaggttcag tggcagtggg tctgggagag acttcactct caccatcagc 240
agcctagagc ctgaagattt tgcagtttat tactgtcagc agcgtagcaa ctggcctcca 300
ttcactttcg gccctgggac caaagtggat atcaaacgcg tacgatatca tgctactgtg 360
gctgcaccat ctgtcttcat cttcc 385
<210> 185
<211> 356
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 185
cttggagagc catcctccat ttcctgcagg tctggtcaga gcccctttca tgggaaacct 60
tctagaaatg gaaacactta cttgaattgg tttctgcaga agccagacca acctctaagg 120
tgcctgattt atgaagtttc taacaggaag tctggggtct cgggcaggtt cagcagcagt 180
ggttcaggga cagatttcat attgaaaatc agcagggtag aggctgagga cgttggggtt 240
tattactgcc tgcaaggtac acaagtgcct gtgcactttt ggccagggga ccaagctgga 300
gatcaaactg ccgaatagtc atgctactgt ggctgcacca tctgtcttca tcttcc 356
<210> 186
<211> 385
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 186
gaaattgtgc tgactcagtc tccagacttt cagtctgtga ctccaaagga atggcgtcca 60
atgaaagtca ccatcacctg ccgggccagt cagagcattg gtagtagctt acactggtac 120
cagcagaaac cagatcagtc tccaaagctc ctcatcaagt atgcttccca gtccatctca 180
ggggtcccct cgaggttcag tggcagtgga tctgggacag atttcaccct caccatcaat 240
agcctggaag ctgaagatgc tgcaacgtat tactgtcatc agagtagtag tttacctcaa 300
ttcactttcg gccctgggac caaagtggat atcaaaccga atcttggcaa tgctactgtg 360
gctgcaccat ctgtcttcat cttcc 385
<210> 187
<211> 388
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 187
gaaattgtaa tgacacagtc tccacccacc ctgtctttgt ctccagggga caatggctat 60
cgaagagtca ccctctcctg cagggccagt cagagtgtta gcagcagcta cttaacctgg 120
tatcagcaga aacctggcca ggcgcccagg ctcctcatct atggtgcatc caccagggcc 180
actagcatcc cagccaggtt cagtggcagt gggtctggga cagacttcac tctcaccatc 240
agcagcctgc agcctgaaga ttttgcagtt tattactgtc agcaggatta taacttacct 300
ccgatcacct tcggccaagg gacacgactg gagattaaac tcaactagcg gtatgctact 360
gtggctgcac catctgtctt catcttcc 388
<210> 188
<211> 403
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 188
gatattgtga tgacccagac tccactctcc ctgcccgtca cccctggaga gattcctcaa 60
gggccggcct ccatctcctg caggtctagt cagagcctct tggatagtga tgatggaaac 120
acctatttgg actggtacct gcagaagcca gggcagtctc cacagctcct gatctatacg 180
ctttcctatc gggcctctgg agtcccagac aggttcagtg gcagtgggtc aggcactgat 240
ttcacactga aaatcagcag ggtggaggct gaggatgttg gagtttatta ctgcatgcaa 300
cgtatagagt ttccttcgct cactttcggc ggagggacca aggtggagat caaacgctaa 360
acgctgtatg ctactgtggc tgcaccatct gtcttcatct tcc 403
<210> 189
<211> 385
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 189
gacatccaga tgacccagtc tccttccacc ctgtctgcat ctgtaggaga acagtagcgc 60
ttcagagtca ccatcacttg ccgggccagt cagagtatta gtagctggtt ggcctggtat 120
cagcagaaac cagggaaagc ccctaagctc ctgatctata aggcgtctag tttagaaagt 180
ggggtcccat caaggttcag cggcagtgga tctgggacag aattcactct caccatcagc 240
agcctgcagc ctgatgattt tgcaacttat tactgccaac agtataatag ttattctccg 300
tggacgttcg gccaagggac caaggtggaa atcaaaccga gcgtttaaca tgctactgtg 360
gctgcaccat ctgtcttcat cttcc 385
<210> 190
<211> 385
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 190
gacatccaga tgacccagtc tccttccacc ctgtctgcat ctgtaggaga gccttaatag 60
cgcagagtca ccatcatttg ccgggccagt cagagtatta gtagctggtt ggcctggtat 120
cagcagaaac cagggaaagc ccctaagctc ctgatctatg atgcctccag tttggaaagt 180
ggggtcccat caaggttcag cggcagtgga tctgggacag aattcactct caccatcagc 240
agcctgcagc ctgatgattt tgcaacttat tactgccaac agtataatag ttattctcca 300
ttcactttcg gccctgggac caaagtggat atcaaaccgc ctattaggaa tgctactgtg 360
gctgcaccat ctgtcttcat cttcc 385
<210> 191
<211> 370
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 191
gaaattgtgt tgacacagtc tccagccacc ctgtctttgt ctccagggga acttcgatag 60
cgaagagcca ccctctcctg cagggccagt cagagtgtta gcagcagcta cttagcctgg 120
taccagcaga aacctggcca ggctcccagg ctcctcatct atggtgcatc cagcagggcc 180
actggcatcc cagcaaggtt cagtggcagt gggtctggga cagacttcac tctcaccatc 240
agcagactgg agcctgaaga ttttgcagtt tattactgtc agctgtacag ttttggccag 300
gggaccaagc tggagatcaa acaggctatc actgatgcta ctgtggctgc accatctgtc 360
ttcatcttcc 370
<210> 192
<211> 400
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 192
gatattgtga tgacccagac tccactctcc tcacctgtca cccttggaca tcgaactgta 60
gcgccggcct ccatctcctg caggtctagt caaagcctcg tacacagtga tggaaacacc 120
tacttgagtt ggcttcagca gaggccaggc cagcctccaa gactcctaat ttataagatt 180
tctaaccggt tctctggggt cccagacaga ttcagtggca gtggggcagg gacagatttc 240
acactgaaaa tcagcagggt ggaagctgag gatgtcgggg tttattactg catgcaagct 300
acacaatttc ctcagatcac cttcggccaa gggacacgac tggagattaa acagacttgg 360
catcatgcta ctgtggctgc accatctgtc ttcatcttcc 400
<210> 193
<211> 388
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 193
gaaattgtaa tgacacagtc tccacccacc ctgtctttgt ctccagggga ggacatgctt 60
acaagagtca ccctctcctg cagggccagt cagagtgtta gcagcagcta cttaacctgg 120
tatcagcaga aacctggcca ggcgcccagg ctcctcatct atggtgcatc caccagggcc 180
actagcatcc cagccaggtt cagtggcagt gggtctggga gagacttcac tctcaccatc 240
agcagcctgc agcctgaaga ttttgcagtt tattactgtc agcaggatca taacttacct 300
ccgtggacgt tcggccaagg gaccaaggtg gaaatcaaac gctaagcctt agatgctact 360
gtggctgcac catctgtctt catcttcc 388
<210> 194
<211> 403
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 194
gatattgtga tgacccagac tccactctcc ctgcccgtca cccctggaga gcctgagaac 60
ttgccggcct ccatctcctg caggtctagt cagagcctct tggatagtga tgatggaaac 120
acctatttgg actggtacct gcagaagcca gggcagtctc cacagctcct gatctatacg 180
ctttcctatc gggcctctgg agtcccagac aggttcagtg gcagtgggtc aggcactgat 240
ttcacactga aaatcagcag ggtggaggct gaggatgttg gagtttatta ctgcatgcaa 300
cgtatagagt ttccttcgtg gacgttcggc caagggacca aggtggaaat caaacactcg 360
gcgtaatatg ctactgtggc tgcaccatct gtcttcatct tcc 403
<210> 195
<211> 388
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 195
gaaattgtaa tgacacagtc tccacccacc ctgtctttgt ctccagggga gcgacattta 60
gcaagagtca ccctctcctg cagggccagt cagagtgtta gcagcagcta cttatcctgg 120
taccagcaga aacctgggca ggctcccagg ctcctcatct atggtgcatc caccagggcc 180
actggcatcc cagccaggtt cagtggcagt gggtctggga cagacttcac tctcaccatc 240
agcagcctgc agcctgaaga ttttgcagtt tattactgtc agcaggatta taacttacct 300
ccgtggacgt tcggccaagg gaccaaggtg gaaatcaaac gcattactcg gaatgctact 360
gtggctgcac catctgtctt catcttcc 388
<210> 196
<211> 369
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 196
gaaattgtgt tgacacagtc tccagccacc ctgtctttgt ctccagggga tcgggcaaat 60
ctaagagcca ccctctcctg cagggccagt cagagtgtta gcagcagcta cttagcctgg 120
taccagcaga aacctggcca ggctcccagg ctcctcatct atggtgcatc cagcagggcc 180
actggcatcc cagcaaggtt cagtggcagt gggtctggga cagacttcac tctcaccatc 240
agcagactgg agcctgaaga ttttgcagtt tattactgtc agcattcact ttcggccctg 300
ggaccaaagt ggatatcaaa cagcctcgta agtatgctac tgtggctgca ccatctgtct 360
tcatcttcc 369
<210> 197
<211> 399
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 197
gatgctgtgt gacccagcct ctactctccc tgcccgtcac ccctggaaag gtcctaggaa 60
ctccagcctc tatctcctgt agatccagtc atagcccctt tcacagtaat ggatacacct 120
atttgaattg ggacctacag aagccaggcc agcctccacg gctcctgatt gatttggttt 180
ccaacaggga ccctggagtc ccagacaggt tcagtggcag tgggtcgggg acagatttca 240
tgtttaaaat aaggaggatg gatgctgagg atgttggggt ttattgctgc cagcaaagta 300
cacattattc tccgtggacg ttcggccaag ggaccaaggt ggaaatcaaa cggaaacctc 360
gttatgctac tgtggctgca ccatctgtct tcatcttcc 399
<210> 198
<211> 385
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 198
gccatccagt tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga actagggtct 60
cacagagtca ccatcacttg ccgggcaagt cagggcatta gcagtgcttt agcctgatat 120
cagcagaaac cagggaaagc tcctaagctc ctgatctatg atgcctccag tttggaaagt 180
ggggtcccat caaggttcag cggcagtgga tctgggacag atttcactct caccatcagc 240
agcctgcagc ctgaagattt tgcaacttat tactgtcaac agtttaataa ttaccctcag 300
tgcacttttg gccaggggac caagctggag atcaaacttg gaccgctaaa tgctactgtg 360
gctgcaccat ctgtcttcat cttcc 385
<210> 199
<211> 388
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 199
gaaattgtaa tgacacagtc tccacccacc ctgtctttgt ctccagggga ttcagaccgg 60
ataagagtca ccctctcctg cagggccagt cagagtgtta gcagcagcta cttatcctgg 120
taccagcaga aacctgggca ggctcccagg ctcctcatct atggtgcatc caccagggcc 180
actggcatcc cagccaggtt cagtggcagt gggtctggga cagacttcac tctcaccatc 240
agcagcctgc agcctgaaga ttttgcagtt tattactgtc agcaggatta taacttacct 300
ccattcactt tcggccctgg gaccaaagtg gatatcaaac aagcctcatt ggatgctact 360
gtggctgcac catctgtctt catcttcc 388
<210> 200
<211> 385
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 200
gaaattgtgc tgactcagtc tccagacttt cagtctgtga ctccaaagga tgcactatca 60
gggaaagtca ccatcacctg ccgggccagt cagagcattg gtagtagctt acactggtac 120
cagcagaaac cagatcagtc tccaaagctc ctcatcaagt atgcttccca gtccatctca 180
ggggtcccct cgaggttcag tggcagtgga tctgggacag atttcaccct caccatcaat 240
agcctggaag ctgaagatgc tgcaacgtat tactgtcatc agagtagtag tttacctcag 300
tggacgttcg gccaagggac caaggtggaa atcaaacgga ctttcgacaa tgctactgtg 360
gctgcaccat ctgtcttcat cttcc 385
<210> 201
<211> 388
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 201
cagtctgtgt tgacgcagcc gccctcagtg tctgcggccc caggacagaa aggttaccgt 60
acggtcacca tctcctgctc tggaagcagc tccaacattg ggaataatta tgtatcctgg 120
taccagcagc tcccaggaac agcccccaaa ctcctcattt atgacaataa taagcgaccc 180
tcagggattc ctgaccgatt ctctggctcc aagtctggca cgtcagccac cctgggcatc 240
accggactcc agactgggga cgaggccgat tattactgcg gaacatggga tagcagcctg 300
agtgctggtg tggtattcgg cggagggacc aagctgaccg tcctagcgga acttcagtat 360
gctactgagg agctycaagc caacaagg 388
<210> 202
<211> 388
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 202
cagtctgtgt tgacgcagcc gccctcagtg tctgcggccc caggacagaa cgcatcttag 60
gaggtcacca tctcctgctc tggaagcagc tccaacattg ggaataatta tgtatcctgg 120
taccagcagc tcccaggaac agcccccaaa ctcctcatct atgaaaataa taagcgaccc 180
tcagggattc ctgaccgatt ctctggctcc aagtctggca cgtcagccac cctgggcatc 240
accggactcc agactgggga cgaggccgat tattactgcg gaacatggga tagcagcctg 300
agtgctggtg tggtattcgg cggagggacc aagctgaccg tcctaggggt ccttacaaat 360
gctactgagg agctycaagc caacaagg 388
<210> 203
<211> 388
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 203
cagtctgtgc tgactcagcc accctcggtg tctgaagccc ccaggcagag tgtaacgatc 60
cgggtcacca tctcctgttc tggaagcagc tccaacatcg gaaataatgc tgtaaactgg 120
taccagcagc tcccaggaaa ggctcccaaa ctcctcatct attatgatga tctgctgccc 180
tcaggggtct ctgaccgatt ctctggctcc aagtctggca cctcagcctc cctggccatc 240
agtgggctcc agtctgagga tgaggctgat tattactgtg cagcatggga tgacagcctg 300
aatggtcctg ctgtgttcgg aggaggcacc cagctgaccg ccctcgagca ttaccgtgat 360
gctactgagg agctycaagc caacaagg 388
<210> 204
<211> 388
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 204
cagtctgtgc tgactcagcc accctcagcg tctgggaccc ccgggcagag cgaacttagg 60
tcggtcacca tctcttgttc tggaagcagc tccaacatcg gaagtaatta tgtatactgg 120
taccagcagc tcccaggaac ggcccccaaa ctcctcatct ataggaataa tcagcggccc 180
tcaggggtcc ctgaccgatt ctctggctcc aagtctggca cctcagcctc cctggccatc 240
agtgggctcc ggtccgagga tgaggctgat tattactgtg cagcatggga tgacagcctg 300
agtggtcctt atgtcttcgg aactgggacc aaggtcaccg tcctagcaac gtggttcaat 360
gctactgagg agctycaagc caacaagg 388
<210> 205
<211> 388
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 205
cagtctgtgc tgactcagcc accctcagcg tctgggaccc ccgggcagag aacctctggg 60
atggtcacca tctcttgttc tggaagcagc tccaacatcg gaagtaatta tgtatactgg 120
taccagcagc tcccaggaac ggcccccaaa ctcctcatct ataggaataa tcagcggccc 180
tcaggggtcc ctgaccgatt ctctggctcc aagtctggca cctcagcctc cctggccatc 240
agtgggctcc ggtccgagga tgaggctgat tattactgtg cagcatggga tgacagcctg 300
agtggtccta atgtgttcgg cagtggcacc aaggtgaccg tcctcgtaac agttgcgcat 360
gctactgagg agctycaagc caacaagg 388
<210> 206
<211> 382
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 206
tcctatgtgc tgactcagcc accctcggtg tcagtggccc caggacagac gcctacatag 60
gtggccagga ttacctgtgg gggaaacaac attggaagta aaagtgtgca ctggtaccag 120
cagaagccag gccaggcccc tgtgctggtc gtctatgatg atagcgaccg gccctcaggg 180
atccctgagc gattctctgg ctccaactct gggaacacgg ccaccctgac catcagcagg 240
gtcgaagccg gggatgaggc cgactattac tgtcaggtgt gggatagtag tagtgatcat 300
cctgctgtgt tcggaggagg cacccagctg accgtcctcg attggatacc cgatgctact 360
gaggagctyc aagccaacaa gg 382
<210> 207
<211> 391
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 207
cagcctgtgc tgactcaatc atcctctgcc tctgcttccc tgggatcctc gtttaacagg 60
ccggtcaagc tcacctgcac tctgagcagt gggcacagta gctacatcat cgcatggcat 120
cagcagcagc cagggaaggc ccctcggtac ttgatgaagc ttgaaggtag tggaagctac 180
aacaagggga gcggagttcc tgatcgcttc tcaggctcca gctctggggc tgaccgctac 240
ctcaccatct ccaacctcca gtttgaggat gaggctgatt attactgtga gacctgggac 300
agtaacactc atgtggtatt cggcggaggg accaagctga ccgtcctagc gtacacttag 360
gatgctactg aggagctyca agccaacaag g 391
<210> 208
<211> 375
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 208
cctctgagct gactcagctg cctgcagtgt ctgtggcttt gggacgtgcg agtaatgtcc 60
cggccaggat catctgccag ggagatagca taggtgactc tgatacaaac tcgtaccagc 120
agaagccagg tcaggtccct gtgctggtaa tttatggtga cagcaaccag ccctcagtga 180
ttcctgagca attttctgac tgcatatcag aggacatggc caccttgatt attaatgggg 240
cacaggatgg aaacaaggct attactgtcg ctcggaacag cactgcttct catctttttg 300
tatttggtgg aggaacccag ctgatcattt tagcaaggag cctttatgct actgaggagc 360
tycaagccaa caagg 375
<210> 209
<211> 388
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 209
cagtctgtgc tgactcagcc accctcggtg tctgaagccc ccaggcagag gacgacattc 60
gtggtcacca tctcctgttc tggaagcagc tccaacatcg gaaataatgc tgtaaactgg 120
taccagcagc tcccaggaaa ggctcccaaa ctcctcatct attatgatga tctgctgccc 180
tcaggggtct ctgaccgatt ctctggctcc aagtctggca cctcagcctc cctggccatc 240
agtgggctcc agtctgagga tgaggctgat tattactgtg cagcatggga tgacagcctg 300
aatggtcctg tggtattcgg cggagggacc aagctgaccg tcctaggacg tagtcctaat 360
gctactgagg agctycaagc caacaagg 388
<210> 210
<211> 382
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 210
tcctatgagc tgacacagcc accctcggtg tcagtgtccc caggacaaac gatggacact 60
ctggccagga tcacctgctc tggagatgca ttgccaaaaa aatatgctta ttggtaccag 120
cagaagtcag gccaggcccc tgtgctggtc atctatgagg acagcaaacg accctccggg 180
atccctgaga gattctctgg ctccagctca gggacaatgg ccaccttgac tatcagtggg 240
gcccaggtgg aggatgaagc tgactactac tgttactcaa cagacagcag tggtaatcat 300
agctgggtgt ttggtgaggg gaccgagctg accgtcctag gggtcaatta ccatgctact 360
gaggagctyc aagccaacaa gg 382
<210> 211
<211> 376
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 211
tcctctgggc caactcaggt gcctgcagtg tctgtggcct tgggacaaat aaccctagtg 60
gtggccagga tcacctgcca gggagacagc atggaaggct cttatgaaca ctggtaccag 120
cagaagccag gccaggcccc cgtgctggtc atctatgata gcagtgaccg gccctcaagg 180
atccctgagc gattctctgg ctccaaatca ggcaacacaa ccaccctgac catcactggg 240
gcccaggctg aggatgaggc tgattattac tatcagttga tagacaacca tgctactgct 300
gtgttcggag gaggcaccca gctgaccgcc ctcgcaacta ttgggcatgc tactgaggag 360
ctycaagcca acaagg 376
<210> 212
<211> 388
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 212
cagtctgtgc tgactcagcc accctcagcg tctgggaccc ccgggcagag gtagcagtta 60
ccggtcacca tctcttgttc tggaagcagc tccaacatcg gaagtaatta tgtatactgg 120
taccagcagc tcccaggaac ggcccccaaa ctcctcatct ataggaataa tcagcggccc 180
tcaggggtcc ctgaccgatt ctctggctcc aagtctggca cctcagcctc cctggccatc 240
agtgggctcc ggtccgagga tgaggctgat tattactgtg cagcatggga tgacagcctg 300
agtggtcctg ctgtgttcgg aggaggcacc cagctgaccg tcctcgactg gcaattcgat 360
gctactgagg agctycaagc caacaagg 388
<210> 213
<211> 388
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 213
cagactgtgg tgacccagga gccatcgttc tcagtgtccc ctggagggac tctggaccaa 60
tgagtcacac tcacttgtgg cttgagctct ggctcagtct ctactagtta ctaccccagc 120
tggtaccagc agaccccagg ccaggctcca cgcacgctca tctacagcac aaacactcgc 180
tcttctgggg tccctgattg cttctctggc tccatccttg ggaacaaagc tgccctcacc 240
atcacggggg cccaggcaga tgatgaatct gattattact gtgtgctgta tatgggtagt 300
ggcatttctg ctgtgttcgg aggaggcacc cagctgaccg ccctcggtta cacggctaat 360
gctactgagg agctycaagc caacaagg 388
<210> 214
<211> 388
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 214
cagtctgtgc tgactcagcc accctcagcg tctgggaccc ccgggcagag aaccgattcg 60
tgggtcacca tctcttgttc tggaagcagc tccaacatcg gaagtaatta tgtatactgg 120
taccagcagc tcccaggaac ggcccccaaa ctcctcatct atagtaataa tcagcggccc 180
tcaggggtcc ctgaccgatt ctctggctcc aagtctggca cctcagcctc cctggccatc 240
agtgggctcc ggtccgagga tgaggctgat tattactgtg cagcatggga tgacagcctg 300
agtggtcctg tggtattcgg cggagggacc aagctgaccg tcctagagct attggcacat 360
gctactgagg agctycaagc caacaagg 388
<210> 215
<211> 376
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 215
tcctatgagc tgacacagct accctcggtg tcagtgtccc caggacagac gcttaggaac 60
ctagccagga tcacctgctc tggagatgta ctgggggaaa attatgctga ctggtaccag 120
cagaagccag gccaggcccc tgagttggtg atatacgaag atagtgagcg gtaccctgga 180
atccctgaac gattctctgg gtccacctca gggaacacga ccaccctgac catcagcagg 240
gtcctgaccg aagacgaggc tgactattac tgtttgtctg gggatgagga caatccttgg 300
gtgttcggcg gagggaccaa gctgaccgtc ctagtgctac gatagcatgc tactgaggag 360
ctycaagcca acaagg 376
<210> 216
<211> 381
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 216
cctatgagct gactcagcca ctctcagtgt cagtggccct gggacaggcc gtactcggaa 60
tggccaggat tacctgtggg ggaaacaacc ttggatataa aagtgtgcac tggtaccagc 120
agaagccagg ccaggcccct gtgctggtca tctataggga taacaaccgg ccctctggga 180
tccctgagcg attctctggc tccaactcgg ggaacacggc caccctgacc atcagcagag 240
cccaagccgg ggatgaggct gactattact gtcaggtgtg ggacagcagc actgcacacc 300
cctgggtgtt tggtgagggg acggagctga ccgtcctagg aaccatcgtt gatgctactg 360
aggagctyca agccaacaag g 381
<210> 217
<211> 391
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 217
cagcttgtgc tgactcaatc gccctctgcc tctgcctccc tgggagcctc tttcgaacga 60
gcggtcaagc tcacctgcac tctgagcagt gggcacagca gctacgccat cgcatggcat 120
cagcagcagc cagagaaggg ccctcggtac ttgatgaagc ttaacagtga tggcagccac 180
agtaaggggg acgggatccc tgatcgcttc tcaggctcca gctctggggc tgagcgctac 240
ctcaccatct ccagcctcca gtctgaggat gaggctgact attactgtca gacctggggc 300
actggcattc atgctgtgtt cggaggaggc acccagctga ccgccctcga cactggtgta 360
catgctactg aggagctyca agccaacaag g 391
<210> 218
<211> 391
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 218
cagtctgtgc tgacgcagcc gccctcagtg tctggggccc cagggcagag tgcctacgga 60
atggtcacca tctcctgcac tgggagcagc tccaacattg gggcgggtta tgttgtacat 120
tggtaccagc agcttccagg aacagccccc aaactcctca tctatggtaa cagcaatcgg 180
ccctcagggg tccctgacca attctctggc tccaagtctg gcacctcagc ctccctggcc 240
atcactggac tccagtctga ggatgaggct gattattact gcaaagcatg ggataacagc 300
ctgaatgctc atgctgtgtt cggaggaggc acccagctga ccgtcctcga cggatagtcc 360
tatgctactg aggagctyca agccaacaag g 391
<210> 219
<211> 382
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 219
tcctatgtgc tgactcagcc accctcagtg tcagtggccc caggaaagac gaaccgcgtt 60
taggccagga ttacctgtgg gggaaacaac attggaagta aaagtgtgca ctggtaccag 120
cagaagccag gccaggcccc tgtgctggtc atctattatg atagcgaccg gccctcaggg 180
atccctgagc gattctctgg ctccaactct gggaacacgg ccaccctgac catcagcagg 240
gtcgaagccg gggatgaggc cgactattac tgtcaggtgt gggacagtag tagtgatcat 300
ccttgggtgt tcggcggagg gaccaagctg accgtcctag tacgctagga tcatgctact 360
gaggagctyc aagccaacaa gg 382
<210> 220
<211> 375
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 220
cctctgagct gactcagctg cctgcagtgt ctgtggcttt gggacgtgct aacgcgatct 60
gggccaggat catctgccag ggagatagca taggtgactc tgatacaaac tcgtaccagc 120
agaagccagg tcaggtccct gtgctggtaa tttatggtga cagcaaccag ccctcagtga 180
ttcctgagca attttctgac tgcatatcag aggacatggc caccttgatt attaatgggg 240
cacaggatgg aaacaaggct attactgtcg ctcggaacag cactgcttct catcttaatg 300
tgttcggcag tggcaccaag gtgaccgtcc tcgcgcgatc taatgatgct actgaggagc 360
tycaagccaa caagg 375
<210> 221
<211> 382
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 221
tcctatgagc tgatgcagcc accctcggtg tcagtgtccc caggacagac ccacttaggt 60
agggccagga tcacctgctc tggagatgca ttgccaaagc aatatgctta ttggtaccag 120
cagaagccag gccaggcccc tgtgctggtg atatataaag acagtgagag gccctcaggg 180
atccctgagc gattctctgg ctccagctca gggacaacag tcacgttgac catcagtgga 240
gtccaggcag aagatgaggc tgactattac tgtcaatcag cagacagcag tggtacttat 300
ccctgggtgt ttggtgaggg gaccgagctg accgtcctag aacgcttagc gtatgctact 360
gaggagctyc aagccaacaa gg 382
<210> 222
<211> 376
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 222
tcctatgagc tgacacagct accctcggtg tcagtgtccc caggacagac cttggaatca 60
gcagccagga tcacctgctc tggagatgta ctgggggaaa attatgctga ctggtaccag 120
cagaagccag gccaggcccc tgagttggtg atatacgaag atagtgagcg gtaccctgga 180
atccctgaac gattctctgg gtccacctca gggaacacga ccaccctgac catcagcagg 240
gtcctgaccg aagacgaggc tgactattac tgtttgtctg gggatgagga caatcctgtg 300
gtattcggcg gagggaccaa gctgaccgtc ctagcgtacc tagatgatgc tactgaggag 360
ctycaagcca acaagg 376
<210> 223
<211> 382
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 223
tcctatgtgc tgactcagcc accctcggtg tcagtggccc caggacagac agctcgcata 60
tgggccagga ttacctgtgg gggaaacaac attggaagta aaagtgtgca ctggtaccag 120
cagaagccag gccaggcccc tgtgctggtc gtctatgatg atagcgaccg gccctcaggg 180
atccctgagc gattctctgg ctccaactct gggaacacgg ccaccctgac catcagcagg 240
gtcgaagccg gggatgaggc cgactattac tgtcaggtgt gggatagtag tagtgatcat 300
ccttgggtgt tcggcggagg gaccaagctg accgtcctag tacgaccgtt gaatgctact 360
gaggagctyc aagccaacaa gg 382
<210> 224
<211> 388
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 224
caggcagggc tgactcagcc accctcggtg tccaagggct tgagacagac tccggcgaat 60
tacgccacac tcacctgcac tgggaacagc aacaatgttg gcaaccaagg agcagcttgg 120
ctgcagcagc accagggcca ccctcccaaa ctcctatcct acaggaataa caaccggccc 180
tcagggatct cagagagatt atctgcatcc aggtcaggaa acacagcctc cctgaccatt 240
actggactcc agcctgagga cgaggctgac tattactgct cagcatggga cagcagcctc 300
agtgctcact gggtgtttgg tgaggggacc gagctgaccg tcctagagta atcgccgtat 360
gctactgagg agctycaagc caacaagg 388
<210> 225
<211> 382
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 225
tcctatgagc tgactcagcc acactcagtg tcagtggcca cagcacagat taacgcagtg 60
tcggccagga tcacctgtgg gggaaacaac attggaagta aagctgtgca ctggtaccag 120
caaaagccag gccaggaccc tgtgctggtc atctatagcg atagcaaccg gccctcaggg 180
atccctgagc gattctctgg ctccaaccca gggaacaccg ccaccctaac catcagcagg 240
atcgaggctg gggatgaggc tgactattac tgtcaggtgt gggacagtag tagtgatcat 300
ccctgggtgt ttggtgaggg gacggagctg accgtcctag gaccattgta gcatgctact 360
gaggagctyc aagccaacaa gg 382
<210> 226
<211> 382
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 226
tcctatgagc tgactcagcc acactcagtg tcagtggcca cagcacagat acttctaacg 60
ggggccagga tcacctgtgg gggaaacaac attggaagta aagctgtgca ctggtaccag 120
caaaagccag gccaggaccc tgtgctggtc atctatagcg atagcaaccg gccctcaggg 180
atccctgagc gattctctgg ctccaaccca gggaacacca ccaccctaac catcagcagg 240
atcgaggctg gggatgaggc tgactattac tgtcaggtgt gggacagtag tagtgatcat 300
cctgtggtat tcggcggagg gaccaagctg accgtcctag agactcttac ggatgctact 360
gaggagctyc aagccaacaa gg 382
<210> 227
<211> 409
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 227
cagcctgtgc tgactcagcc atcttcccat tctgcatctt ctggagcatc cctggaatgt 60
acagtcagac tcacctgcat gctgagcagt ggcttcagtg ttggggactt ctggataagg 120
tggtaccaac aaaagccagg gaaccctccc cggtatctcc tgtactacca ctcagactcc 180
aataagggcc aaggctctgg agttcccagc cgcttctctg gatccaacga tgcatcagcc 240
aatgcaggga ttctgcgtat ctctgggctc cagcctgagg atgaggctga ctattactgt 300
ggtacatggc acagcaactc taagactcac tgggtgtttg gtgaggggac ggagctgacc 360
gtcctagttt gaaagcgcca tgctactgag gagctycaag ccaacaagg 409
<210> 228
<211> 382
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 228
tcctatgtgc tgactcagcc accctcggtg tcagtggccc caggaaagac gacgttgata 60
ccggccagga ttacctgtgg gggaaacaac attggaagta aaagtgtgca ctggtaccag 120
cagaagccag gccaggcccc tgtgctggtc gtctatgatg atagcgaccg gccctcaggg 180
atccctgagc gattctctgg ctccaactct gggaacacgg ccaccctgac catcagcagg 240
gtcgaagccg gggatgaggc cgactattac tgtcaggtgt gggatagtag tagtgatcat 300
cctaatgtgt tcggcagtgg caccaaggtg accgtcctcg ccggtatata gcatgctact 360
gaggagctyc aagccaacaa gg 382
<210> 229
<211> 388
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 229
aattttatgc tgactcagcc ccactctgtg tcggagtctc cggggaagac ggcgcacaat 60
ttggtaacca tctcctgcac ccgcagcagt ggcagcattg ccagcaacta tgtgcagtgg 120
taccagcagc gcccgggcag ttcccccacc actgtgatct atgaggataa ccaaagaccc 180
tctggggtcc ctgatcggtt ctctggctcc atcgacagct cctccaactc tgcctccctc 240
accatctctg gactgaagac tgaggacgag gctgactact actgtcagtc ttatgatagc 300
agcaatcatt atgtcttcgg aactgggacc aaggtcaccg tcctagtact tgcacaggat 360
gctactgagg agctycaagc caacaagg 388
<210> 230
<211> 388
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 230
cagactgtgg tgacccagga gccatcgttc tcagtgtccc ctggagggac gaagctccat 60
tgagtcacac tcacttgtgg cttgagctct ggctcagtct ctactagtta ctaccccagc 120
tggtaccagc agaccccagg ccaggctcca cgcacgctca tctacagcac aaacactcgc 180
tcttctgggg tccctgattg cttctctggc tccatccttg ggaacaaagc tgccctcacc 240
atcacggggg cccaggcaga tgatgaatct gattattact gtgtgctgta tatgggtagt 300
ggcatttctg ctgtgttcgg aggaggcacc cagctgaccg tcctcgcgga ttgccaatat 360
gctactgagg agctycaagc caacaagg 388
<210> 231
<211> 388
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 231
cagtctgtgt tgacgcagcc gccctcagtg tctgcggccc caggacagaa ccgttctaga 60
agggtcacca tctcctgctc tggaagcagc tccaacattg ggaataatta tgtatcctgg 120
taccagcagc tcccaggaac agcccccaaa ctcctcatct atgaaaataa taagcgaccc 180
tcagggattc ctgaccgatt ctctggctcc aagtctggca cgtcagccac cctgggcatc 240
accggactcc agactgggga cgaggccgat tattactgcg gaacatggga tagcagcctg 300
agtgctggta atgtgttcgg cagtggcacc aaggtgaccg tcctcgtcgg agtacatcat 360
gctactgagg agctycaagc caacaagg 388
<210> 232
<211> 391
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 232
cagcttgtgc tgactcaatc gccctctgcc tctgcctccc tgggagcctc attccgcaag 60
tgggtcaagc tcacctgcac tctgagcagt gggcacagca gctacgccat cgcatggcat 120
cagcagcagc cagagaaggg ccctcggtac ttgatgaagc ttaacagtga tggcagccac 180
agtaaggggg acgggatccc tgatcgcttc tcaggctcca gctctggggc tgagcgctac 240
ctcaccatct ccagcctcca gtctgaggat gaggctgact attactgtca gacctggggc 300
actggcattc attatgtctt cggaactggg accaaggtca ccgtcctaga tactacggtc 360
gatgctactg aggagctyca agccaacaag g 391
<210> 233
<211> 382
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 233
tcctatgagc tgacacagcc accctcggtg tcagtgtccc taggacagat gcgcatacat 60
tgggccagga tcacctgctc tggagaagca ttgccaaaaa aatatgctta ttggtaccag 120
cagaagccag gccagttccc tgtgctggtg atatataaag acagcgagag gccctcaggg 180
atccctgagc gattctctgg ctccagctca gggacaatag tcacattgac catcagtgga 240
gtccaggcag aagacgaggc tgactattac tgtctatcag cagacagcag tggtacttat 300
cctgctgtgt tcggaggagg cacccagctg accgtcctcg aacgagttct cgatgctact 360
gaggagctyc aagccaacaa gg 382
<210> 234
<211> 388
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 234
cagactgtgg tgacccagga gccatcgttc tcagtgtccc ctggagggac gaactcgtcg 60
atagtcacac tcacttgtgg cttgagctct ggctcagtct ctactagtta ctaccccagc 120
tggtaccagc agaccccagg ccaggctcca cgcacgctca tctacagcac aaacactcgc 180
tcttctgggg tccctgattg cttctctggc tccatccttg ggaacaaagc tgccctcacc 240
atcacggggg cccaggcaga tgatgaatct gattattact gtgtgctgta tatgggtagt 300
ggcatttctt ttgtatttgg tggaggaacc cagctgatca ttttagtagc atacgtgcat 360
gctactgagg agctycaagc caacaagg 388
<210> 235
<211> 376
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 235
tcctctgggc caactcaggt gcctgcagtg tctgtggcct tgggacaaat gaatcgtatg 60
ccggccagga tcacctgcca gggagacagc atggaaggct cttatgaaca ctggtaccag 120
cagaagccag gccaggcccc cgtgctggtc atctatgata gcagtgaccg gccctcaagg 180
atccctgagc gattctctgg ctccaaatca ggcaacacaa ccaccctgac catcactggg 240
gcccaggctg aggatgaggc tgattattac tatcagttga tagacaacca tgctactaat 300
gtgttcggca gtggcaccaa ggtgaccgtc ctcgtgactc tggaacatgc tactgaggag 360
ctycaagcca acaagg 376
<210> 236
<211> 388
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 236
caggcagggc tgactcagcc accctcggtc tccaagggct tgagacagac aaagtggcct 60
ctcgccacac tcacctgcac tgggaacagc aacaatgttg gcaaccaagg agcagcttgg 120
cctgagcagc accagggcca ccctcccaaa ctcctatcct acaggaataa caaccggccc 180
tcagggatct cagagagatt atctgcatcc aggtcaggaa acacagcctc cctgaccatt 240
actggactcc agcctgagga cgaggctgac tattactgct cagcatggga cagcagcctc 300
agtgctcatt atgtcttcgg aactgggacc aaggtcaccg tcctagatga ggccctatat 360
gctactgagg agctycaagc caacaagg 388
<210> 237
<211> 376
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 237
tcctctgggc caactcaggt gcctgcagtg tctgtggcct tgggacaaat tgattaggca 60
ccggccagga tcacctgcca gggagacagc atggaaggct cttatgaaca ctggtaccag 120
cagaagccag gccaggcccc cgtgctggtc atctatgata gcagtgaccg gccctcaagg 180
atccctgagc gattctctgg ctccaaatca ggcaacacaa ccaccctgac catcactggg 240
gcccaggctg aggatgaggc tgattattac tatcagttga tagacaacca tgctactttt 300
gtatttggtg gaggaaccca gctgatcatt ttagtaccgg tgatacatgc tactgaggag 360
ctycaagcca acaagg 376
<210> 238
<211> 382
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 238
tcttctgagc tgactcagga ccctgctgtg tctgtggcct tgggacagac ttaggcatac 60
cgagtcagga tcacatgcca aggagacagc ctcagaagct attatgcaag ctggtaccag 120
cagaagccag gacaggcccc tgtacttgtc atctatggta aaaacaaccg gccctcaggg 180
atcccagacc gattctctgg ctccagctca ggaaacacag cttccttgac catcactggg 240
gctcaggcgg aagatgaggc tgactattac tgtaactccc gggacagcag tggtaaccat 300
ctctgggtgt ttggtgaggg gaccgagctg accgtcctag tgcgctcgta aaatgctact 360
gaggagctyc aagccaacaa gg 382
<210> 239
<211> 388
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 239
cagactgtgg tgacccagga gccatcgttc tcagtgtccc ctggagggac accgttggaa 60
tcagtcacac tcacttgtgg cttgagctct ggctcagtct ctactagtta ctaccccagc 120
tggtaccagc agaccccagg ccaggctcca cgcacgctca tctacagcac aaacactcgc 180
tcttctgggg tccctgatcg cttctctggc tccatccttg ggaacaaagc tgccctcacc 240
atcacggggg cccaggcaga tgatgaatct gattattact gtgtgctgta tatgggtagt 300
ggcatttctg tggtattcgg cggagggacc aagctgaccg tcctagtaaa gcttcgcgat 360
gctactgagg agctycaagc caacaagg 388
<210> 240
<211> 381
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 240
cctatgagct gactcagcca ctctcagtgt cagtggccct gggacaggcc gtacaactgg 60
tggccaggat tacctgtggg ggaaacaacc ttggatataa aagtgtgcac tggtaccagc 120
agaagccagg ccaggcccct gtgctggtca tctataggga taacaaccgg ccctctggga 180
tccctgagcg attctctggc tccaactcgg ggaacacggc caccctgacc atcagcagag 240
cccaagccgg ggatgaggct gactattact gtcaggtgtg ggacagcagc actgcacacc 300
cctgggtgtt tggtgagggg accgagctga ccgtcctaga cgattctagc gatgctactg 360
aggagctyca agccaacaag g 381
<210> 241
<211> 388
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 241
cagtctgtgt tgacgcagcc gccttcagtg tctgcggccc caggacagaa cttgcaacgg 60
taggtcacca tctcctgctc tggaagcagc tccgacatgg ggaattatgc ggtatcctgg 120
taccagcagc tcccaggaac agcccccaaa ctcctcatct atgaaaataa taagcgaccc 180
tcagggattc ctgaccgatt ctctggctcc aagtctggca cctcagccac cctgggcatc 240
actggcctct ggcctgagga cgaggccgat tattactgct tagcatggga taccagcccg 300
agagcttgtt gggtgttcgg cggagggacc aagctgaccg tcctagtttg accagcgaat 360
gctactgagg agctycaagc caacaagg 388
<210> 242
<211> 382
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 242
tcctatgagc tgacacagcc accctcggtg tcagtgtccc taggacagat gtaacgtccg 60
atggccagga tcacctgctc tggagaagca ttgccaaaaa aatatgctta ttggtaccag 120
cagaagccag gccagttccc tgtgctggtg atatataaag acagcgagag gccctcaggg 180
atccctgagc gattctctgg ctccagctca gggacaatag tcacattgac catcagtgga 240
gtccaggcag aagacgaggc tgactattac tgtctatcag cagacagcag tggtacttat 300
ccctgggtgt ttggtgaggg gacggagctg accgtcctag tatccgcgat agatgctact 360
gaggagctyc aagccaacaa gg 382
<210> 243
<211> 409
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 243
cagcctgtgc tgactcagcc atcttcccat tctgcatctt ctggagcatc tttacggcac 60
agagtcagac tcacctgcat gctgagcagt ggcttcagtg ttggggactt ctggataagg 120
tggtaccaac aaaagccagg gaaccctccc cggtatctcc tgtactacca ctcagactcc 180
aataagggcc aaggctctgg agttcccagc cgcttctctg gatccaacga tgcatcagcc 240
aatgcaggga ttctgcgtat ctctgggctc cagcctgagg atgaggctga ctattactgt 300
ggtacatggc acagcaactc taagactcat gctgtgttcg gaggaggcac ccagctgacc 360
gccctcgtcg gaattccaga tgctactgag gagctycaag ccaacaagg 409
<210> 244
<211> 388
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 244
cagactgtgg tgacccagga gccatcgttc tcagtgtccc ctggagggac acgaagtcgt 60
tcagtcacac tcacttgtgg cttgagctct ggctcagtct ctactagtta ctaccccagc 120
tggtaccagc agaccccagg ccaggctcca cgcacgctca tctacagcac aaacactcgc 180
tcttctgggg tccctgatcg cttctctggc tccatccttg ggaacaaagc tgccctcacc 240
atcacggggg cccaggcaga tgatgaatct gattattact gtgtgctgta tatgggtagt 300
ggcatttcta atgtgttcgg cagtggcacc aaggtgaccg tcctcgtaga tcactggcat 360
gctactgagg agctycaagc caacaagg 388
<210> 245
<211> 375
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 245
cctctgagct gactcagctg cctgcagtgt ctgtggcttt gggacgtgcc gttagtaagc 60
cggccaggat catctgccag ggagatagca taggtgactc tgatacaaac tcgtaccagc 120
agaagccagg tcaggtccct gtgctggtaa tttatggtga cagcaaccag ccctcagtga 180
ttcctgagca attttctgac tgcatatcag aggacatggc caccttgatt attaatgggg 240
cacaggatgg aaacaaggct attactgtcg ctcggaacag cactgcttct catcttgtgg 300
tattcggcgg agggaccaag ctgaccgtcc taggttcgac aatgcatgct actgaggagc 360
tycaagccaa caagg 375
<210> 246
<211> 382
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 246
tcctatgagc tgactcagcc acactcagtg tcagtggcca cagcacagat tcgacaactg 60
tgggccagga tcacctgtgg gggaaacaac attggaagta aagctgtgca ctggtaccag 120
caaaagccag gccaggaccc tgtgctggtc atctatagcg atagcaaccg gccctcaggg 180
atccctgagc gattctctgg ctccaaccca gggaacacca ccaccctaac catcagcagg 240
atcgaggctg gggatgaggc tgactattac tgtcaggtgt gggacagtag tagtgatcat 300
ccttatgtct tcggaactgg gaccaaggtc accgtcctag acggattcag tcatgctact 360
gaggagctyc aagccaacaa gg 382
<210> 247
<211> 391
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 247
cagtctgtgc tgacgcagcc gccctcagtg tctggggccc cagggcagag gtagattcag 60
ccggtcacca tctcctgcac tgggagcagc tccaacatcg gggcaggtta tgatgtacac 120
tggtaccagc agcttccagg aacagccccc aaactcctca tctatggtaa cagcaatcgg 180
ccctcagggg tccctgaccg attctctggc tccaagtctg gcacctcagc ctccctggcc 240
atcactgggc tccaggctga ggatgaggct gattattact gccagtccta tgacagcagc 300
ctgagtggtt ctgctgtgtt cggaggaggc acccagctga ccgccctcgg ctcgacgatt 360
aatgctactg aggagctyca agccaacaag g 391
<210> 248
<211> 388
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 248
cagtctgtgt tgacgcagcc gccttcagtg tctgcggccc caggacagaa taggccgcta 60
taggtcacca tctcctgctc tggaagcagc tccgacatgg ggaattatgc ggtatcctgg 120
taccagcagc tcccaggaac agcccccaaa ctcctcatct atgaaaataa taagcgaccc 180
tcagggattc ctgaccgatt ctctggctcc aagtctggca cctcagccac cctgggcatc 240
actggcctct ggcctgagga cgaggccgat tattactgct tagcatggga taccagcccg 300
agagcttgtt ttgtatttgg tggaggaacc cagctgatca ttttaggaga ttcgcctaat 360
gctactgagg agctycaagc caacaagg 388
<210> 249
<211> 388
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 249
aattttatgc tgactcagcc ccactctgtg tcggagtctc cggggaagac atagggcctt 60
caggtaacca tctcctgcac cggcagcagt ggcagcattg ccagcaacta tgtgcagtgg 120
taccagcagc gcccgggcag tgcccccacc actgtgatct atgaggataa ccaaagaccc 180
tctggggtcc ctgatcggtt ctctggctcc atcgacagct cctccaactc tgcctccctc 240
accatctctg gactgaagac tgaggacgag gctgactact actgtcagtc ttatgatagc 300
agcaatcatg ctgtgttcgg aggaggcacc cagctgaccg tcctcgtaac tggaccgtat 360
gctactgagg agctycaagc caacaagg 388
<210> 250
<211> 382
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 250
tcctatgagc tgacacagcc accctcggtg tcagtgtccc caggacagac tgggtcacaa 60
tcggccagga tcacctgctc tggagatgca ttgccaaagc aatatgctta ttggtaccag 120
cagaagccag gccaggcccc tgtgctggtg atatataaag acagtgagag gccctcaggg 180
atccctgagc gattctctgg ctccagctca gggacaacag tcacgttgac catcagtgga 240
gtccaggcag aagatgaggc tgactattac tgtcaatcag cagacagcag tggtacttat 300
ccttatgtct tcggaactgg gaccaaggtc accgtcctag agagtactcg ctatgctact 360
gaggagctyc aagccaacaa gg 382
<210> 251
<211> 388
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 251
cagactgtgg tgacccagga gccatcgttc tcagtgtccc ctggagggac tcttagcaag 60
gcagtcacac tcacttgtgg cttgagctct ggctcagtct ctactagtta ctaccccagc 120
tggtaccagc agaccccagg ccaggctcca cgcacgctca tctacagcac aaacactcgc 180
tcttctgggg tccctgattg cttctctggc tccatccttg ggaacaaagc tgccctcacc 240
atcacggggg cccaggcaga tgatgaatct gattattact gtgtgctgta tatgggtagt 300
ggcatttcct gggtgtttgg tgaggggacc gagctgaccg tcctagtgaa catgtgccat 360
gctactgagg agctycaagc caacaagg 388
<210> 252
<211> 382
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 252
tcctatgtgc tgactcagcc accctcagtg tcagtggccc caggaaagac cggagttcta 60
caggccagga ttacctgtgg gggaaacaac attggaagta aaagtgtgca ctggtaccag 120
cagaagccag gccaggcccc tgtgctggtc atctattatg atagcgaccg gccctcaggg 180
atccctgagc gattctctgg ctccaactct gggaacacgg ccaccctgac catcagcagg 240
gtcgaagccg gggatgaggc cgactattac tgtcaggtgt gggacagtag tagtgatcat 300
cctgtggtat tcggcggagg gaccaagctg accgtcctag ggcaagttac ctatgctact 360
gaggagctyc aagccaacaa gg 382
<210> 253
<211> 388
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 253
caggcagggc tgactcagcc accctcggtg tccaagggct tgagacagac atctaagcgc 60
gtcgccacac tcacctgcac tgggaacagc aacaatgttg gcaaccaagg agcagcttgg 120
ctgcagcagc accagggcca ccctcccaaa ctcctatcct acaggaataa caaccggccc 180
tcagggatct cagagagatt atctgcatcc aggtcaggaa acacagcctc cctgaccatt 240
actggactcc agcctgagga cgaggctgac tattactgct cagcatggga cagcagcctc 300
agtgctcatt ttgtatttgg tggaggaacc cagctgatca ttttagtatg ggaccatcat 360
gctactgagg agctycaagc caacaagg 388
<210> 254
<211> 375
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 254
cctctgagct gactcagctg cctgcagtgt ctgtggcttt gggacgtgct ggtaaatgcc 60
cggccaggat catctgccag ggagatagca taggtgactc tgatacaaac tcgtaccagc 120
agaagccagg tcaggtccct gtgctggtaa tttatggtga cagcaaccag ccctcagtga 180
ttcctgagca attttctgac tgcatatcag aggacatggc caccttgatt attaatgggg 240
cacaggatgg aaacaaggct attactgtcg ctcggaacag cactgcttct catctctggg 300
tgtttggtga ggggacggag ctgaccgtcc taggttaggt ccacaatgct actgaggagc 360
tycaagccaa caagg 375
<210> 255
<211> 391
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 255
cagcttgtgc tgactcaatc gccctctgcc tctgcctccc tgggagcctc ccagttggac 60
atggtcaagc tcacctgcac tctgagcagt gggcacagca gctacgccat cgcatggcat 120
cagcagcagc cagagaaggg ccctcggtac ttgatgaagc ttaacagtga tggcagccac 180
agcaaggggg acgggatccc tgatcgcttc tcaggctcca gctctggggc tgagcgctac 240
ctcaccatct ccagcctcca gtctgaggat gaggctgact attactgtca gacctggggc 300
actggcattc actgggtgtt tggtgagggg acggagctga ccgtcctagc ttgagaacct 360
gatgctactg aggagctyca agccaacaag g 391
<210> 256
<211> 388
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 256
aattttatgc tgactcagcc ccactctgtg tcggagtctc cggggaagac atggtaaccc 60
gtggtaacca tctcctgcac cggcagcagt ggcagcattg ccagcaacta tgtgcagtgg 120
taccagcagc gcccgggcag tgcccccacc actgtgatct atgaggataa ccaaagaccc 180
tctggggtcc ctgatcggtt ctctggctcc atcgacagct cctccaactc tgcctccctc 240
accatctctg gactgaagac tgaggacgag gctgactact actgtcagtc ttatgatagc 300
agcaatcact gggtgtttgg tgaggggacg gagctgaccg tcctagtagc gcgcttaaat 360
gctactgagg agctycaagc caacaagg 388
<210> 257
<211> 391
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 257
cagcttgtgc tgactcaatc gccctctgcc tctgcctccc tgggagcctc caccagagtg 60
ttggtcaagc tcacctgcac tctgagcagt gggcacagca gctacgccat cgcatggcat 120
cagcagcagc cagagaaggg ccctcggtac ttgatgaagc ttaacagtga tggcagccac 180
agcaaggggg acgggatccc tgatcgcttc tcaggctcca gctctggggc tgagcgctac 240
ctcaccatct ccagcctcca gtctgaggat gaggctgact attactgtca gacctggggc 300
actggcattc attatgtctt cggaactggg accaaggtca ccgtcctaga ggatccatct 360
gatgctactg aggagctyca agccaacaag g 391
<210> 258
<211> 382
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 258
tcttctgagc tgactcagga ccctgctgtg tctgtggcct tgggacagac atggatccta 60
gcagtcagga tcacatgcca aggagacagc ctcagaagct attatgcaag ctggtaccag 120
cagaagccag gacaggcccc tgtacttgtc atctatggta aaaacaaccg gccctcaggg 180
atcccagacc gattctctgg ctccagctca ggaaacacag cttccttgac catcactggg 240
gctcaggcgg aagatgaggc tgactattac tgtaactccc gggacagcag tggtaaccat 300
cttgctgtgt tcggaggagg cacccagctg accgccctcg gggacattca ctatgctact 360
gaggagctyc aagccaacaa gg 382
<210> 259
<211> 381
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 259
cctatgagct gactcagcca ctctcagtgt cagtggccct gggacaggcc gagacgttac 60
tggccaggat tacctgtggg ggaaacaacc ttggatataa aagtgtgcac tggtaccagc 120
agaagccagg ccaggcccct gtgctggtca tctataggga taacaaccgg ccctctggga 180
tccctgagcg attctctggc tccaactcgg ggaacacggc caccctgacc atcagcagag 240
cccaagccgg ggatgaggct gactattact gtcaggtgtg ggacagcagc actgcacacc 300
cttatgtctt cggaactggg accaaggtca ccgtcctagc ggcgaaactt tatgctactg 360
aggagctyca agccaacaag g 381
<210> 260
<211> 382
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 260
tcctatgagc tgacacagcc accctcggtg tcagtgtccc caggacaaac tccaggctta 60
gaggccagga tcacctgctc tggagatgca ttgccaaaaa aatatgctta ttggtaccag 120
cagaagtcag gccaggcccc tgtgctggtc atctatgagg acagcaaacg accctccggg 180
atccctgaga gattctctgg ctccagctca gggacaatgg ccaccttgac tatcagtggg 240
gcccaggtgg aggatgaagc tgactactac tgttactcaa cagacagcag tggtaatcat 300
agtgtggtat tcggcggagg gaccaagctg accgtcctag gggccttcaa taatgctact 360
gaggagctyc aagccaacaa gg 382
<210> 261
<211> 388
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 261
caggcagggc tgactcagcc accctcggtc tccaagggct tgagacagac agactagctt 60
cgcgccacac tcacctgcac tgggaacagc aacaatgttg gcaaccaagg agcagcttgg 120
cctgagcagc accagggcca ccctcccaaa ctcctatcct acaggaataa caaccggccc 180
tcagggatct cagagagatt atctgcatcc aggtcaggaa acacagcctc cctgaccatt 240
actggactcc agcctgagga cgaggctgac tattactgct cagcatggga cagcagcctc 300
agtgctcata atgtgttcgg cagtggcacc aaggtgaccg tcctcgcgta attcggcaat 360
gctactgagg agctycaagc caacaagg 388
<210> 262
<211> 409
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 262
cagcctgtgc tgactcagcc atcttcccat tctgcatctt ctggagcatc gtaatcctag 60
gcagtcagac tcacctgcat gctgagcagt ggcttcagtg ttggggactt ctggataagg 120
tggtaccaac aaaagccagg gaaccctccc cggtatctcc tgtactacca ctcagactcc 180
aataagggcc aaggctctgg agttcccagc cgcttctctg gatccaacga tgcatcagcc 240
aatgcaggga ttctgcgtat ctctgggctc cagcctgagg atgaggctga ctattactgt 300
ggtacatggc acagcaactc taagactcat tttgtatttg gtggaggaac ccagctgatc 360
attttagacg ggatttcaca tgctactgag gagctycaag ccaacaagg 409
<210> 263
<211> 376
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 263
tcctatgagc tgacacagcc atcctcagtg tcagtgtctc cgggacagac cgtaggacat 60
tcagccagga tcacctgctc aggagatgta ctggcaaaaa aatatgctcg gtggttccag 120
cagaagccag gccaggcccc tgtgctggtg atttataaag acagtgagcg gccctcaggg 180
atccctgagc gattctccgg ctccagctca gggaccacag tcaccttgac catcagcggg 240
gcccaggttg aggatgaggc tgactattac tgttactctg cggctgacaa caatctctgg 300
gtgtttggtg aggggaccga gctgaccgtc ctagttacgg agacctatgc tactgaggag 360
ctycaagcca acaagg 376
<210> 264
<211> 382
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 264
tcctatgagc tgactcagcc acactcagtg tcagtggcca cagcacagat caataccttg 60
ggggccagga tcacctgtgg gggaaacaac attggaagta aagctgtgca ctggtaccag 120
caaaagccag gccaggaccc tgtgctggtc atctatagcg atagcaaccg gccctcaggg 180
atccctgagc gattctctgg ctccaaccca gggaacaccg ccaccctaac catcagcagg 240
atcgaggctg gggatgaggc tgactattac tgtcaggtgt gggacagtag tagtgatcat 300
cctgtggtat tcggcggagg gaccaagctg accgtcctag tctaaggacg tcatgctact 360
gaggagctyc aagccaacaa gg 382
<210> 265
<211> 376
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 265
tcctctgggc caactcaggt gcctgcagtg tctgtggcct tgggacaaat attatagcgc 60
cgggccagga tcacctgcca gggagacagc atggaaggct cttatgaaca ctggtaccag 120
cagaagccag gccaggcccc cgtgctggtc atctatgata gcagtgaccg gccctcaagg 180
atccctgagc gattctctgg ctccaaatca ggcaacacaa ccaccctgac catcactggg 240
gcccaggctg aggatgaggc tgattattac tatcagttga tagacaacca tgctacctgg 300
gtgtttggtg aggggaccga gctgaccgtc ctagtgatag atcccgatgc tactgaggag 360
ctycaagcca acaagg 376
<210> 266
<211> 388
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 266
cagactgtgg tgacccagga gccatcgttc tcagtgtccc ctggagggac gtagcttcga 60
caagtcacac tcacttgtgg cttgagctct ggctcagtct ctactagtta ctaccccagc 120
tggtaccagc agaccccagg ccaggctcca cgcacgctca tctacagcac aaacactcgc 180
tcttctgggg tccctgatcg cttctctggc tccatccttg ggaacaaagc tgccctcacc 240
atcacggggg cccaggcaga tgatgaatct gattattact gtgtgctgta tatgggtagt 300
ggcatttctg ctgtgttcgg aggaggcacc cagctgaccg tcctcgtgga agcacttcat 360
gctactgagg agctycaagc caacaagg 388
<210> 267
<211> 382
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 267
tcctatgagc tgatgcagcc accctcggtg tcagtgtccc caggacagac tcggtcaaca 60
gtggccagga tcacctgctc tggagatgca ttgccaaagc aatatgctta ttggtaccag 120
cagaagccag gccaggcccc tgtgctggtg atatataaag acagtgagag gccctcaggg 180
atccctgagc gattctctgg ctccagctca gggacaacag tcacgttgac catcagtgga 240
gtccaggcag aagatgaggc tgactattac tgtcaatcag cagacagcag tggtacttat 300
ccttttgtat ttggtggagg aacccagctg atcattttag tggtacacat gcatgctact 360
gaggagctyc aagccaacaa gg 382
<210> 268
<211> 391
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 268
cagcctgtgc tgactcaatc atcctctgcc tctgcttccc tgggatcctc tggactccat 60
agggtcaagc tcacctgcac tctgagcagt gggcacagta gctacatcat cgcatggcat 120
cagcagcagc cagggaaggc ccctcggtac ttgatgaagc ttgaaggtag tggaagctac 180
aacaagggga gcggagttcc tgatcgcttc tcaggctcca gctctggggc tgaccgctac 240
ctcaccatct ccaacctcca gtttgaggat gaggctgatt attactgtga gacctgggac 300
agtaacactc attgggtgtt cggcggaggg accaagctga ccgtcctaga attcgggacc 360
tatgctactg aggagctyca agccaacaag g 391
<210> 269
<211> 382
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 269
tcctatgagc tgatgcagcc accctcggtg tcagtgtccc caggacagac tgagaaccgt 60
tcggccagga tcacctgctc tggagatgca ttgccaaagc aatatgctta ttggtaccag 120
cagaagccag gccaggcccc tgtgctggtg atatataaag acagtgagag gccctcaggg 180
atccctgagc gattctctgg ctccagctca gggacaacag tcacgttgac catcagtgga 240
gtccaggcag aagatgaggc tgactattac tgtcaatcag cagacagcag tggtacttat 300
cctgctgtgt tcggaggagg cacccagctg accgtcctcg ggcgctatat acatgctact 360
gaggagctyc aagccaacaa gg 382
<210> 270
<211> 382
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 270
tcctatgtgc tgactcagcc accctcggtg tcagtggccc caggacagac taaggtctag 60
ccggccagga ttacctgtgg gggaaacaac attggaagta aaagtgtgca ctggtaccag 120
cagaagccag gccaggcccc tgtgctggtc gtctatgatg atagcgaccg gccctcaggg 180
atccctgagc gattctctgg ctccaactct gggaacacgg ccaccctgac catcagcagg 240
gtcgaagccg gggatgaggc cgactattac tgtcaggtgt gggatagtag tagtgatcat 300
cctgtggtat tcggcggagg gaccaagctg accgtcctag gtactcagac gtatgctact 360
gaggagctyc aagccaacaa gg 382
<210> 271
<211> 391
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 271
cagtctgtgc tgacgcagcc gccctcagtg tctggggccc cagggcagag cgtcgcatag 60
taggtcacca tctcctgcac tgggagcagc tccaacattg gggcgggtta tgttgtacat 120
tggtaccagc agcttccagg aacagccccc aaactcctca tctatggtaa cagcaatcgg 180
ccctcagggg tccctgacca attctctggc tccaagtctg gcacctcagc ctccctggcc 240
atcactggac tccagtctga ggatgaggct gattattact gcaaagcatg ggataacagc 300
ctgaatgctc actgggtgtt tggtgagggg accgagctga ccgtcctagc actgcgagta 360
tatgctactg aggagctyca agccaacaag g 391
<210> 272
<211> 388
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 272
cagtctgtgt tgacgcagcc gccttcagtg tctgcggccc caggacagaa aggaatttgc 60
ccggtcacca tctcctgctc tggaagcagc tccgacatgg ggaattatgc ggtatcctgg 120
taccagcagc tcccaggaac agcccccaaa ctcctcatct atgaaaataa taagcgaccc 180
tcagggattc ctgaccgatt ctctggctcc aagtctggca cctcagccac cctgggcatc 240
actggcctct ggcctgagga cgaggccgat tattactgct tagcatggga taccagcccg 300
agagcttgtg tggtattcgg cggagggacc aagctgaccg tcctagaact tgatggccat 360
gctactgagg agctycaagc caacaagg 388
<210> 273
<211> 376
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 273
tcctatgagc tgacacagct accctcggtg tcagtgtccc caggacagac gctctggcaa 60
taagccagga tcacctgctc tggagatgta ctgggggaaa attatgctga ctggtaccag 120
cagaagccag gccaggcccc tgagttggtg atatacgaag atagtgagcg gtaccctgga 180
atccctgaac gattctctgg gtccacctca gggaacacga ccaccctgac catcagcagg 240
gtcctgaccg aagacgaggc tgactattac tgtttgtctg gggatgagga caatccttat 300
gtcttcggaa ctgggaccaa ggtcaccgtc ctagcgcaag atttgcatgc tactgaggag 360
ctycaagcca acaagg 376
<210> 274
<211> 382
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 274
tcctatgagc tgacacagcc accctcggtg tcagtgtccc taggacagat tttacccagg 60
agggccagga tcacctgctc tggagaagca ttgccaaaaa aatatgctta ttggtaccag 120
cagaagccag gccagttccc tgtgctggtg atatataaag acagcgagag gccctcaggg 180
atccctgagc gattctctgg ctccagctca gggacaatag tcacattgac catcagtgga 240
gtccaggcag aagacgaggc tgactattac tgtctatcag cagacagcag tggtacttat 300
ccttatgtct tcggaactgg gaccaaggtc accgtcctag tttcagcaac ggatgctact 360
gaggagctyc aagccaacaa gg 382
<210> 275
<211> 376
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 275
tcctatgagc tgacacagct accctcggtg tcagtgtccc caggacagac gatcctgtaa 60
cgagccagga tcacctgctc tggagatgta ctgggggaaa attatgctga ctggtaccag 120
cagaagccag gccaggcccc tgagttggtg atatacgaag atagtgagcg gtaccctgga 180
atccctgaac gattctctgg gtccacctca gggaacacga ccaccctgac catcagcagg 240
gtcctgaccg aagacgaggc tgactattac tgtttgtctg gggatgagga caatcctgct 300
gtgttcggag gaggcaccca gctgaccgcc ctcgtagccc ttaaggatgc tactgaggag 360
ctycaagcca acaagg 376
<210> 276
<211> 409
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 276
cagcctgtgc tgactcagcc atcttcccat tctgcatctt ctggagcatc atgacggttc 60
caagtcagac tcacctgcat gctgagcagt ggcttcagtg ttggggactt ctggataagg 120
tggtaccaac aaaagccagg gaaccctccc cggtatctcc tgtactacca ctcagactcc 180
aataagggcc aaggctctgg agttcccagc cgcttctctg gatccaacga tgcatcagcc 240
aatgcaggga ttctgcgtat ctctgggctc cagcctgagg atgaggctga ctattactgt 300
ggtacatggc acagcaactc taagactcat tatgtcttcg gaactgggac caaggtcacc 360
gtcctaggag taccactgta tgctactgag gagctycaag ccaacaagg 409
<210> 277
<211> 388
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 277
cagtctgtgc tgactcagcc accctcagcg tctgggaccc ccgggcagag ctgagacatt 60
gcggtcacca tctcttgttc tggaagcagc tccaacatcg gaagtaatac tgtaaactgg 120
taccagcagc tcccaggaac ggcccccaaa ctcctcatct atagtaataa tcagcggccc 180
tcaggggtcc ctgaccgatt ctctggctcc aagtctggca cctcagcctc cctggccatc 240
agtgggctcc agtctgagga tgaggctgat tattactgtg cagcatggga tgacagcctg 300
aatggtcctt ttgtatttgg tggaggaacc cagctgatca ttttagatag gcattcgcat 360
gctactgagg agctycaagc caacaagg 388
<210> 278
<211> 391
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 278
cagtctgtcg tgacgcagcc gccctcagtg tctggggccc cagggcagag gctccaatta 60
ggggtcacca tctcctgcac tgggagcagc tccaacatcg gggcaggtta tgatgtacac 120
tggtaccagc agcttccagg aacagccccc aaactcctca tctatggtaa cagcaatcgg 180
ccctcagggg tccctgaccg attctctggc tccaagtctg gcacctcagc ctccctggcc 240
atcactgggc tccaggctga ggatgaggct gattattact gccagtccta tgacagcagc 300
ctgagtggtt cctgggtgtt tggtgagggg acggagctga ccgtcctaga ggtcactacg 360
tatgctactg aggagctyca agccaacaag g 391
<210> 279
<211> 382
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 279
tcctatgagc tgacacagcc accctcggtg tcagtgtccc caggacagac cgatcaagtt 60
cgggccagga tcacctgctc tggagatgca ttgccaaagc aatatgctta ttggtaccag 120
cagaagccag gccaggcccc tgtgctggtg atatataaag acagtgagag gccctcaggg 180
atccctgagc gattctctgg ctccagctca gggacaacag tcacgttgac catcagtgga 240
gtccaggcag aagatgaggc tgactattac tgtcaatcag cagacagcag tggtacttat 300
cctaatgtgt tcggcagtgg caccaaggtg accgtcctcg gatcgcttaa gcatgctact 360
gaggagctyc aagccaacaa gg 382
<210> 280
<211> 382
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 280
tcctatgagc tgactcagcc acactcagtg tcagtggcca cagcacagat cggttccaat 60
gaggccagga tcacctgtgg gggaaacaac attggaagta aagctgtgca ctggtaccag 120
caaaagccag gccaggaccc tgtgctggtc atctatagcg atagcaaccg gccctcaggg 180
atccctgagc gattctctgg ctccaaccca gggaacacca ccaccctaac catcagcagg 240
atcgaggctg gggatgaggc tgactattac tgtcaggtgt gggacagtag tagtgatcat 300
cctgtggtat tcggcggagg gaccaagctg accgtcctag ggaatctgca tcatgctact 360
gaggagctyc aagccaacaa gg 382
<210> 281
<211> 382
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 281
tcctatgagc tgacacagcc accctcggtg tcagtgtccc caggacaaac aagcgtcgca 60
ttggccagga tcacctgctc tggagatgca ttgccaaaaa aatatgctta ttggtaccag 120
cagaagtcag gccaggcccc tgtgctggtc atctatgagg acagcaaacg accctccggg 180
atccctgaga gattctctgg ctccagctca gggacaatgg ccaccttgac tatcagtggg 240
gcccaggtgg aggatgaagc tgactactac tgttactcaa cagacagcag tggtaatcat 300
agttgggtgt tcggcggagg gaccaagctg accgtcctag ggacatgttc caatgctact 360
gaggagctyc aagccaacaa gg 382
<210> 282
<211> 376
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 282
cctctgagct gactcagctg cctgcagtgt ctgtggcttt gggacgtact cggcaaattg 60
cggccaggat catctgccag ggagatagca taggtgactc tgatacaaac tcgtaccagc 120
agaagccagg tcaggtccct gtgctggtaa tttatggtga cagcaaccag ccctcagtga 180
ttcctgagca attttctgac tgcatatcag aggacatggc caccttgatt attaatgggg 240
gcacaggatg gaaacaaggc tattactgtc gctcggaaca gcactgcttc tcatcttgtg 300
gtattcggcg gagggaccaa gctgaccgtc ctaggctcat taaggcatgc tactgaggag 360
ctycaagcca acaagg 376
<210> 283
<211> 382
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 283
tcctatgtgc tgactcagcc accctcggtg tcagtggccc caggacagac ttgccaatcg 60
gaggccagga ttacctgtgg gggaaacaac attggaagta aaagtgtgca ctggtaccag 120
cagaagccag gccaggcccc tgtgctggtc gtctatgatg atagcgaccg gccctcaggg 180
atccctgagc gattctctgg ctccaactct gggaacacgg ccaccctgac catcagcagg 240
gtcgaagccg gggatgaggc cgactattac tgtcaggtgt gggatagtag tagtgatcat 300
ccttatgtct tcggaactgg gaccaaggtc accgtcctag ataccacttg ggatgctact 360
gaggagctyc aagccaacaa gg 382
<210> 284
<211> 388
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 284
cagtctgtgc tgactcagcc accctcggtg tctgaagccc ccaggcagag ataggtccca 60
tgggtcacca tctcctgttc tggaagcagc tccaacatcg gaaataatgc tgtaaactgg 120
taccagcagc tcccaggaaa ggctcccaaa ctcctcatct attatgatga tctgctgccc 180
tcaggggtct ctgaccgatt ctctggctcc aagtctggca cctcagcctc cctggccatc 240
agtgggctcc agtctgagga tgaggctgat tattactgtg cagcatggga tgacagcctg 300
aatggtcctt ttgtatttgg tggaggaacc cagctgatca ttttagatcg gaagctctat 360
gctactgagg agctycaagc caacaagg 388
<210> 285
<211> 382
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 285
tcctatgagc tgacacagcc accctcggtg tcagtgtccc taggacagat cgccatagta 60
tgggccagga tcacctgctc tggagaagca ttgccaaaaa aatatgctta ttggtaccag 120
cagaagccag gccagttccc tgtgctggtg atatataaag acagcgagag gccctcaggg 180
atccctgagc gattctctgg ctccagctca gggacaatag tcacattgac catcagtgga 240
gtccaggcag aagacgaggc tgactattac tgtctatcag cagacagcag tggtacttat 300
cctgtggtat tcggcggagg gaccaagctg accgtcctag tcgtaaggta ccatgctact 360
gaggagctyc aagccaacaa gg 382
<210> 286
<211> 382
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 286
tcctatgagc tgacacagcc accctcggtg tcagtgtccc caggacagac acctggcgat 60
atggccagga tcacctgctc tggagatgca ttgccaaagc aatatgctta ttggtaccag 120
cagaagccag gccaggcccc tgtgctggtg atatataaag acagtgagag gccctcaggg 180
atccctgagc gattctctgg ctccagctca gggacaacag tcacgttgac catcagtgga 240
gtccaggcag aagatgaggc tgactattac tgtcaatcag cagacagcag tggtacttat 300
ccctgggtgt ttggtgaggg gaccgagctg accgtcctag accaatggtc gtatgctact 360
gaggagctyc aagccaacaa gg 382
<210> 287
<211> 382
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 287
tcctatgagc tgactcagcc acactcagtg tcagtggcca cagcacagat gcctcggtaa 60
atggccagga tcacctgtgg gggaaacaac attggaagta aagctgtgca ctggtaccag 120
caaaagccag gccaggaccc tgtgctggtc atctatagcg atagcaaccg gccctcaggg 180
atccctgagc gattctctgg ctccaaccca gggaacaccg ccaccctaac catcagcagg 240
atcgaggctg gggatgaggc tgactattac tgtcaggtgt gggacagtag tagtgatcat 300
cctaatgtgt tcggcagtgg caccaaggtg accgtcctcg ggatccattc gaatgctact 360
gaggagctyc aagccaacaa gg 382
<210> 288
<211> 388
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 288
cagactgtgg tgacccagga gccatcgttc tcagtgtccc ctggagggac aatacggctc 60
gtagtcacac tcacttgtgg cttgagctct ggctcagtct ctactagtta ctaccccagc 120
tggtaccagc agaccccagg ccaggctcca cgcacgctca tctacagcac aaacactcgc 180
tcttctgggg tccctgattg cttctctggc tccatccttg ggaacaaagc tgccctcacc 240
atcacggggg cccaggcaga tgatgaatct gattattact gtgtgctgta tatgggtagt 300
ggcatttctt atgtcttcgg aactgggacc aaggtcaccg tcctagctta ggccatagat 360
gctactgagg agctycaagc caacaagg 388
<210> 289
<211> 409
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 289
cagcctgtgc tgactcagcc atcttcccat tctgcatctt ctggagcatc tgcactcaag 60
gtagtcagac tcacctgcat gctgagcagt ggcttcagtg ttggggactt ctggataagg 120
tggtaccaac aaaagccagg gaaccctccc cggtatctcc tgtactacca ctcagactcc 180
aataagggcc aaggctctgg agttcccagc cgcttctctg gatccaacga tgcatcagcc 240
aatgcaggga ttctgcgtat ctctgggctc cagcctgagg atgaggctga ctattactgt 300
ggtacatggc acagcaactc taagactcac tgggtgtttg gtgaggggac cgagctgacc 360
gtcctaggta acggtaccta tgctactgag gagctycaag ccaacaagg 409
<210> 290
<211> 388
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 290
aattttatgc tgactcagcc ccactctgtg tcggagtctc cggggaagac ctccttaaag 60
ggggtaacca tctcctgcac cggcagcagt ggcagcattg ccagcaacta tgtgcagtgg 120
taccagcagc gcccgggcag tgcccccacc actgtgatct atgaggataa ccaaagaccc 180
tctggggtcc ctgatcggtt ctctggctcc atcgacagct cctccaactc tgcctccctc 240
accatctctg gactgaagac tgaggacgag gctgactact actgtcagtc ttatgatagc 300
agcaatcatt ttgtatttgg tggaggaacc cagctgatca ttttaggaca atctcggtat 360
gctactgagg agctycaagc caacaagg 388
<210> 291
<211> 375
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 291
cctctgagct gactcagctg cctgcagtgt ctgtggcttt gggacgtgca tggcacgcat 60
tggccaggat catctgccag ggagatagca taggtgactc tgatacaaac tcgtaccagc 120
agaagccagg tcaggtccct gtgctggtaa tttatggtga cagcaaccag ccctcagtga 180
ttcctgagca attttctgac tgcatatcag aggacatggc caccttgatt attaatgggg 240
cacaggatgg aaacaaggct attactgtcg ctcggaacag cactgcttct catcttgctg 300
tgttcggagg aggcacccag ctgaccgtcc tcgtcgaaag cctgtatgct actgaggagc 360
tycaagccaa caagg 375
<210> 292
<211> 388
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 292
cagtctgtgc tgactcagcc accctcagcg tctgggaccc ccgggcagag tcgactggat 60
acggtcacca tctcttgttc tggaagcagc tccaacatcg gaagtaatta tgtatactgg 120
taccagcagc tcccaggaac ggcccccaaa ctcctcatct atagtaataa tcagcggccc 180
tcaggggtcc ctgaccgatt ctctggctcc aagtctggca cctcagcctc cctggccatc 240
agtgggctcc ggtccgagga tgaggctgat tattactgtg cagcatggga tgacagcctg 300
agtggtcctt atgtcttcgg aactgggacc aaggtcaccg tcctagctgg aactcgtaat 360
gctactgagg agctycaagc caacaagg 388
<210> 293
<211> 388
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 293
cagtctgtgt tgacgcagcc gccctcagtg tctgcggccc caggacagaa tgtagcatca 60
gcggtcacca tctcctgctc tggaagcagc tccaacattg ggaataatta tgtatcctgg 120
taccagcagc tcccaggaac agcccccaaa ctcctcattt atgacaataa taagcgaccc 180
tcagggattc ctgaccgatt ctctggctcc aagtctggca cgtcagccac cctgggcatc 240
accggactcc agactgggga cgaggccgat tattactgcg gaacatggga tagcagcctg 300
agtgctggtt gggtgttcgg cggagggacc aagctgaccg tcctagtaat actcggcgat 360
gctactgagg agctycaagc caacaagg 388
<210> 294
<211> 376
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 294
tcctatgagc tgacacagcc atcctcagtg tcagtgtctc cgggacagac tatgacactc 60
ggagccagga tcacctgctc aggagatgta ctggcaaaaa aatatgctcg gtggttccag 120
cagaagccag gccaggcccc tgtgctggtg atttataaag acagtgagcg gccctcaggg 180
atccctgagc gattctccgg ctccagctca gggaccacag tcaccttgac catcagcggg 240
gcccaggttg aggatgaggc tgactattac tgttactctg cggctgacaa caatcttgct 300
gtgttcggag gaggcaccca gctgaccgtc ctcgttaaca tcgggcatgc tactgaggag 360
ctycaagcca acaagg 376
<210> 295
<211> 376
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 295
tcctatgagc tgacacagcc atcctcagtg tcagtgtctc cgggacagac cggtgcatct 60
aaagccagga tcacctgctc aggagatgta ctggcaaaaa aatatgctcg gtggttccag 120
cagaagccag gccaggcccc tgtgctggtg atttataaag acagtgagcg gccctcaggg 180
atccctgagc gattctccgg ctccagctca gggaccacag tcaccttgac catcagcggg 240
gcccaggttg aggatgaggc tgactattac tgttactctg cggctgacaa caatcttaat 300
gtgttcggca gtggcaccaa ggtgaccgtc ctcggccgat cgtataatgc tactgaggag 360
ctycaagcca acaagg 376
<210> 296
<211> 388
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 296
cagtctgtgt tgacgcagcc gccttcagtg tctgcggccc caggacagaa aatggtgcat 60
ccggtcacca tctcctgctc tggaagcagc tccgacatgg ggaattatgc ggtatcctgg 120
taccagcagc tcccaggaac agcccccaaa ctcctcatct atgaaaataa taagcgaccc 180
tcagggattc ctgaccgatt ctctggctcc aagtctggca cctcagccac cctgggcatc 240
actggcctct ggcctgagga cgaggccgat tattactgct tagcatggga taccagcccg 300
agagcttgct gggtgtttgg tgaggggacc gagctgaccg tcctagcgtg aaatcgtcat 360
gctactgagg agctycaagc caacaagg 388
<210> 297
<211> 388
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 297
cagactgtgg tgacccagga gccatcgttc tcagtgtccc ctggagggac ctgactcggt 60
aaagtcacac tcacttgtgg cttgagctct ggctcagtct ctactagtta ctaccccagc 120
tggtaccagc agaccccagg ccaggctcca cgcacgctca tctacagcac aaacactcgc 180
tcttctgggg tccctgatcg cttctctggc tccatccttg ggaacaaagc tgccctcacc 240
atcacggggg cccaggcaga tgatgaatct gattattact gtgtgctgta tatgggtagt 300
ggcatttcct gggtgtttgg tgaggggacg gagctgaccg tcctagttcg aacagtcgat 360
gctactgagg agctycaagc caacaagg 388
<210> 298
<211> 376
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 298
tcctatgagc tgacacagct accctcggtg tcagtgtccc caggacagac gagcttcaat 60
gcagccagga tcacctgctc tggagatgta ctgggggaaa attatgctga ctggtaccag 120
cagaagccag gccaggcccc tgagttggtg atatacgaag atagtgagcg gtaccctgga 180
atccctgaac gattctctgg gtccacctca gggaacacga ccaccctgac catcagcagg 240
gtcctgaccg aagacgaggc tgactattac tgtttgtctg gggatgagga caatccctgg 300
gtgtttggtg aggggacgga gctgaccgtc ctaggtactt aaggccatgc tactgaggag 360
ctycaagcca acaagg 376
<210> 299
<211> 391
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 299
cagcctgtgc tgactcaatc atcctctgcc tctgcttccc tgggatcctc gctcgatatc 60
gaggtcaagc tcacctgcac tctgagcagt gggcacagta gctacatcat cgcatggcat 120
cagcagcagc cagggaaggc ccctcggtac ttgatgaagc ttgaaggtag tggaagctac 180
aacaagggga gcggagttcc tgatcgcttc tcaggctcca gctctggggc tgaccgctac 240
ctcaccatct ccaacctcca gtttgaggat gaggctgatt attactgtga gacctgggac 300
agtaacactc attatgtctt cggaactggg accaaggtca ccgtcctagc acaggatttc 360
gatgctactg aggagctyca agccaacaag g 391
<210> 300
<211> 388
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 300
aattttatgc tgactcagcc ccactctgtg tcggagtctc cggggaagac aggaacgttt 60
ccggtaacca tctcctgcac ccgcagcagt ggcagcattg ccagcaacta tgtgcagtgg 120
taccagcagc gcccgggcag ttcccccacc actgtgatct atgaggataa ccaaagaccc 180
tctggggtcc ctgatcggtt ctctggctcc atcgacagct cctccaactc tgcctccctc 240
accatctctg gactgaagac tgaggacgag gctgactact actgtcagtc ttatgatagc 300
agcaatcatg tggtattcgg cggagggacc aagctgaccg tcctaggacg tcgaattcat 360
gctactgagg agctycaagc caacaagg 388
<210> 301
<211> 18
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 301
gaggtgcagc tggtggag 18
<210> 302
<211> 18
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 302
caggtgcagc tggtggag 18
<210> 303
<211> 18
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 303
caggtgcagc tggtgcag 18
<210> 304
<211> 18
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 304
caggtcacct tgaaggag 18
<210> 305
<211> 18
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 305
gaggtgcagc tgttggag 18
<210> 306
<211> 18
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 306
caggtgcagc tggtgcaa 18
<210> 307
<211> 18
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 307
caaatgcagc tggtgcag 18
<210> 308
<211> 18
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 308
tctggtggct ccgtcagc 18
<210> 309
<211> 18
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 309
agaagcctgg gtcctcgg 18
<210> 310
<211> 18
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 310
aaaagcccgg ggagtctc 18
<210> 311
<211> 18
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 311
accttcagtg accactac 18
<210> 312
<211> 18
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 312
tgcgctggtg aaacccac 18
<210> 313
<211> 18
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 313
gctccatcag cagtagta 18
<210> 314
<211> 18
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 314
caggtgcagc tgttggag 18
<210> 315
<211> 18
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 315
caggtgcagc tggtggac 18
<210> 316
<211> 18
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 316
caggtgcagc tacaggag 18
<210> 317
<211> 18
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 317
caggtccagc ttgtgcag 18
<210> 318
<211> 18
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 318
caggtccagc tggtacag 18
<210> 319
<211> 18
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 319
ctctggtggc tccatcag 18
<210> 320
<211> 18
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 320
gaggtccagc tggtacag 18
<210> 321
<211> 18
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 321
tatggtgggt ccttcagt 18
<210> 322
<211> 18
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 322
tctggtggct ccatcagt 18
<210> 323
<211> 18
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 323
cgggtcacct tgagggag 18
<210> 324
<211> 18
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 324
gctggtgaaa cccacaca 18
<210> 325
<211> 18
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 325
agaagcctgg ggctacag 18
<210> 326
<211> 18
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 326
gaggtacaac tggtggag 18
<210> 327
<211> 18
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 327
caggtgcagc tacaacag 18
<210> 328
<211> 18
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 328
gaaattgtgc tgactcag 18
<210> 329
<211> 18
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 329
gatattgtga tgacccag 18
<210> 330
<211> 18
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 330
gacatccagt tgacccag 18
<210> 331
<211> 18
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 331
gatgttgtga tgacacag 18
<210> 332
<211> 18
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 332
gaaattgtgt tgacacag 18
<210> 333
<211> 18
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 333
gacatccaga tgatccag 18
<210> 334
<211> 18
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 334
gccatccagt tgacccag 18
<210> 335
<211> 18
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 335
gaaatagtga tgacgcag 18
<210> 336
<211> 18
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 336
gccatctgga tgacccag 18
<210> 337
<211> 18
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 337
tcctatgtgc tgactcag 18
<210> 338
<211> 18
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 338
tcctatgagc tgactcag 18
<210> 339
<211> 18
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 339
cagcttgtgc tgactcaa 18
<210> 340
<211> 18
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 340
caggctgtgc tgactcag 18
<210> 341
<211> 18
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 341
caggcagggc tgactcag 18
<210> 342
<211> 18
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 342
cagtctgtgt tgacgcag 18
<210> 343
<211> 18
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 343
ctccgcgtcc gggtctcc 18
<210> 344
<211> 18
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 344
cagtctgccc tgactcag 18
<210> 345
<211> 18
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 345
cagtctgtcg tgacgcag 18
<210> 346
<211> 18
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 346
ctcagtgtcc gggtctcc 18
<210> 347
<211> 26
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 347
ggggaagacc gatgggccct tggtgg 26
<210> 348
<211> 30
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 348
ggaagatgaa gacagatggt gcagccacag 30
<210> 349
<211> 24
<212> DNA
<213> Artificial sequence (Homo sapiens)
<400> 349
ccttgttggc ttgragctcc tcag 24
Claims (1)
1. The construction method of the BCR high-throughput sequencing library is characterized by comprising the following steps of: the method is based on the construction method of a high-throughput sequencing library, which is established by designing a set of primer sets for heavy chain IgH and two light chain IgL and IgK of BCR respectively, amplifying different alleles of all IgH, igL and IgK which are found at present, adding a set of internal reference sequences respectively during amplification, and carrying out the correction of the later-period use internal references so as to truly reduce the real condition of the BCR;
the method comprises the following steps:
s1, preparing a cDNA template: extracting cellular RNA, extracting tissue RNA, performing quality identification and concentration detection on mRNA with the initial tissue quantity of more than 1mg, mixing and synthesizing the total RNA with the total RNA quantity of more than 100ng, preparing a mixed system according to certain requirements, and performing reaction on a PCR instrument to form a product cDNA template;
the preparation of the cDNA template of the S1 comprises the following steps:
(1) Cell RNA extraction: the cell source is lymphocytes obtained by separating human peripheral blood, the number of the cells is more than 500, the cells are added with cell lysate for lysis, and RNA extraction is carried out by using an RNA extraction kit;
(2) Tissue RNA extraction: the tissue sources are tumor tissues and normal tissues which are operated by people, the initial quantity is more than 1mg, the tumor tissues and the normal tissues are ground by adopting liquid nitrogen and then are added with a lysate for cracking, and RNA extraction is carried out by using an RNA extraction kit;
(3) Performing quality identification and concentration detection on mRNA, wherein the mRNA is required to have complete results, and the total RNA amount is more than 100ng;
(4) In order to increase the cDNA yield, we performed a pre-optimization treatment during cDNA synthesis, and prepared a mixed system according to the following table, and reacted on a PCR apparatus, the reaction procedure was: standing horse at 70deg.C for 1min, and placing the product on ice for 3min after the reaction process is completed;
reagent name volume
mRNA100ng-1ug X maximum volume of 10ul
1ug/ul oligodT 1ul
RNAse-free water Up to 12 ul
(5) Preparing a mixed system in the following table, mixing the mixed system with the product in the step (4), and then placing the mixed system on a PCR instrument for reaction, wherein the reaction procedure is as follows: 42 ℃ for 90min;75 ℃ for 15min;4 ℃ and infinity; the product after the reaction is a synthesized cDNA template, and the cDNA template is used for the next step;
reagent name volume
5X Buffer 4ul
0.1M DTT 1ul
10mM dNTP 1ul
40U/ul RNAse Inhibitor 1 ul
200U/ul SuperScript II 1ul
S2, adding 0.1ul of internal reference sequence into the purified cDNA template, and performing PCR reaction to form a product B;
s2 specifically comprises the following steps:
(1) Adding 0.1ul of internal reference sequence into the cDNA template, uniformly mixing the internal reference sequences according to the expression quantity of the V genes of IgH, igK and IgL according to the corresponding proportion, adding only the corresponding internal reference sequence each time according to the requirement of amplification, adding the internal reference corresponding to IgH if the IgH is required to be amplified, uniformly mixing to form a cDNA template A, carrying out PCR reaction as a template, and preparing a reaction system according to the following table;
reagent name volume
2XHiFi Hot Start 25ul
cDNA template A2.5 ul
Primier 1 5ul
Primier 2 5ul
Nuclease-free water 12.5ul
(2) The re-PCR reaction procedure is as follows:
cycle number denaturation annealing extension
1 95℃ 3min -- --
22-32 98℃ 20s -- --
22-32 55℃--60℃ 30s --
22-32 -- -- 72℃ 1min
1 72℃ 5min
(3) After the reaction is finished, purifying the product, and finally eluting with 30ul of nucleic-free water to obtain a product B;
s3, connecting a product B with the high-throughput sequencing joint to obtain a final sequencing library;
the primer added in the step S2 and the internal reference sequence are 349 strips in total;
the primer and internal reference sequence are as follows:
when the receptor is a human BCR IgH heavy chain: the internal reference sequence in the cDNA template A in the step S2 consists of SEQ ID NO. 1-SEQ ID NO. 100;
when the receptor is human BCR IgK light chain: the internal reference sequence in the cDNA template A in the step S2 consists of SEQ ID NO. 101-SEQ ID NO. 200;
when the receptor is human BCR IgL light chain: the internal reference sequence in the cDNA template A in the step S2 consists of SEQ ID NO. 201-SEQ ID NO. 300;
when the receptor is a human BCR IgH heavy chain: the nucleotide sequence of Primer 1 in step S2 consists of SEQ ID NO. 301-SEQ ID NO. 327;
when the receptor is human BCR IgK light chain: the nucleotide sequence of Primer 1 in the step S2 consists of SEQ ID NO. 328-SEQ ID NO. 336;
when the receptor is human BCR IgL light chain: the Primer 1 nucleotide sequence in step S2 consists of SEQ ID NO. 337-SEQ ID NO. 346;
when the receptor is a human BCR IgH heavy chain: the nucleotide sequence of Primer 2 in step S2 consists of SEQ ID NO. 347;
when the receptor is human BCR IgK light chain: the nucleotide sequence of Primer 2 in step S2 consists of SEQ ID NO. 348;
when the receptor is human BCR IgL light chain: the nucleotide sequence of Primer 2 in step S2 consists of SEQ ID NO. 349.
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| CN112301099A (en) * | 2020-11-30 | 2021-02-02 | 南方科技大学 | Primer group for amplifying B lymphocyte immune repertoire and application thereof |
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