CN110916723A - Wearable ultrasonic blood pressure detection and adjustment integrated system with controllable temperature - Google Patents
Wearable ultrasonic blood pressure detection and adjustment integrated system with controllable temperature Download PDFInfo
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Abstract
本发明涉及一种可控温的穿戴式超声血压检测与调节一体化系统，包括柔性贴片、超声发射模块、温度检测模块、温度控制模块、主控电路模块、无线通信模块、显示模块和电源模块；超声发射模块包括两个子模块：超声血压检测模块与超声血压调控模块；超声血压检测模块进行动脉血管定位与动脉血压的实时监测；超声血压调控模块根据实时血压监测数据变化，实现血压自动调节；无线通信模块，用于发射信号、监测数据与主控电路模块间的无线传输；显示模块，用于显示实时监测的血压、温度数值；电源模块，用于提供电源。本发明解决如何利用超声方法实现血压的长期安全监测与调控、超声探头散热、制冷等温控问题。
The invention relates to a temperature-controllable wearable ultrasonic blood pressure detection and adjustment integrated system, comprising a flexible patch, an ultrasonic emission module, a temperature detection module, a temperature control module, a main control circuit module, a wireless communication module, a display module and a power supply module; the ultrasonic transmitter module includes two sub-modules: an ultrasonic blood pressure detection module and an ultrasonic blood pressure control module; the ultrasonic blood pressure detection module performs real-time monitoring of arterial blood vessel positioning and arterial blood pressure; the ultrasonic blood pressure control module realizes automatic blood pressure adjustment according to changes in real-time blood pressure monitoring data ; Wireless communication module, used for transmitting signals, monitoring data and wireless transmission between the main control circuit module; Display module, used to display real-time monitoring of blood pressure, temperature values; Power module, used to provide power. The invention solves the temperature control problems of how to use the ultrasonic method to realize long-term safety monitoring and regulation of blood pressure, heat dissipation of the ultrasonic probe, and refrigeration.
Description
Technical Field
The invention belongs to the field of ultrasonic regulation and control, and relates to a wearable ultrasonic blood pressure detection and regulation integrated system with controllable temperature.
Background
The interventional operation treatment mainly aims at secondary hypertension treatment, for example, renal vascular hypertension can dilate renal arteries through interventional operation treatment, researches prove that the activity of carotid sinus baroreceptors and peripheral autonomic nerves (such as vagus nerves, decompression nerves and the like) can be influenced through physical intervention modes such as electrical stimulation or mechanical stimulation to regulate blood pressure, but invasive operation intervention is also needed, the operation is complex, and the operation risk is higher.
The ultrasonic wave is a mechanical wave, is generated by the vibration of a sound source, can be transmitted in gas, liquid or solid, and has three characteristics of fluctuation effect, mechanical effect and thermal effect. Compared with other regulation and control technologies such as electrical stimulation, transcranial magnetic stimulation, deep brain stimulation and the like, the ultrasonic regulation and control technology has the advantages of no wound, large penetration depth, flexible target point control, capability of image guidance and the like. By selecting focused ultrasonic stimulation with different parameters such as frequency, stimulation intensity and the like, the effect of exciting or inhibiting the activity of stimulation target spots such as nerves and the like can be achieved, and different nerve tissue functions can be adjusted. Therefore, for refractory hypertension, an ultrasonic peripheral nerve stimulation means is researched and developed to replace the traditional electric stimulation interventional operation for regulating blood pressure change, and the method is a new idea and a new method for noninvasive non-drug treatment of hypertension.
However, when the ultrasonic wave vibrates and propagates in the medium, the medium can also generate strong high-frequency vibration, so that the media rub against each other to generate heat, and part of the ultrasonic energy can be absorbed by the medium and converted into heat energy, so that the overall temperature of the medium is increased. In addition, cavitation of ultrasonic waves can cause bubbles in the medium to generate strong shock waves in the processes of expansion, closing, oscillation and the like, and high temperature and high pressure at local points outside the boundary are formed. The heat effect of the ultrasonic wave is the heat converted by the medium after absorbing the sound energy and the heat generated by the ultrasonic cavitation. Thus, thermal effects are an inherent characteristic of ultrasound. In the actual use of the ultrasonic regulation process, the temperature of the ultrasonic probe and the skin tissue of a human body may be increased due to the heat effect of the ultrasonic wave, and the accumulated heat may cause the calibers of skin pores, sweat gland catheters, blood vessels and the like to expand, thereby bringing burning feeling or other uncomfortable feelings to a user and causing potential safety hazards to the user and equipment.
Disclosure of Invention
The invention provides a wearable ultrasonic blood pressure detection and regulation integrated system capable of controlling temperature, which solves the problems of realizing long-term safety monitoring and regulation of blood pressure by using an ultrasonic method, solving the problems of heat dissipation and refrigeration isothermal control of an ultrasonic probe, and reducing the risks of skin burn and the like of a user caused by heat accumulation possibly accompanied by heat effect in the ultrasonic use process.
The technical scheme for solving the problems is as follows: a wearable ultrasonic blood pressure detection and adjustment integrated system with controllable temperature is characterized in that:
the ultrasonic temperature measurement device comprises a flexible patch, an ultrasonic emission module, a temperature detection module, a temperature control module, a main control circuit module, a wireless communication module, a display module and a power supply module; the ultrasonic emission module is arranged on the flexible patch, and the temperature detection module is arranged on the ultrasonic emission module;
the ultrasound transmission module comprises two sub-modules: the ultrasonic blood pressure detection module and the ultrasonic blood pressure regulation module;
the ultrasonic blood pressure detection module and the ultrasonic blood pressure regulation and control module respectively comprise a first ultrasonic probe array and a second ultrasonic probe array;
the ultrasonic blood pressure detection module is used for positioning arterial blood vessels and monitoring arterial blood pressure in real time;
the ultrasonic blood pressure regulation and control module realizes automatic regulation of blood pressure according to the change of real-time blood pressure monitoring data;
the temperature detection module is used for monitoring the surface temperature of the ultrasonic probes of the ultrasonic blood pressure detection module and the ultrasonic blood pressure regulation module in real time, the measured temperature data is transmitted to the main control circuit module through wireless transmission for processing, and the display module displays the surface temperature value of the ultrasonic probe monitored in real time;
the temperature control module is used for controlling the surface temperature of the first ultrasonic probe array and the second ultrasonic probe array in real time;
the main control circuit module comprises a main control circuit and a switch driving circuit; the ultrasonic blood pressure monitoring and controlling module is used for receiving monitoring data of blood pressure and temperature, processing the data, outputting a control instruction, outputting a blood pressure regulating and controlling instruction according to the change of a monitored blood pressure value, starting the switch driving circuit and driving a second ultrasonic probe array of the ultrasonic blood pressure regulating and controlling module to work; outputting a temperature control instruction according to the change of the monitored temperature value, starting a switch driving circuit, and driving a temperature control module to regulate the temperature;
the wireless communication module is used for transmitting signals and monitoring data and wirelessly transmitting the data with the main control circuit module;
the display module is used for displaying the blood pressure and temperature values monitored in real time;
and the power supply module is used for providing power supply.
Preferentially, the ultrasonic blood pressure detection module carries out artery blood vessel positioning and real-time monitoring of artery blood pressure, and specifically comprises the following steps:
the first ultrasonic probe array of the ultrasonic blood pressure detection module can continuously measure the arterial blood pressure waveform, and the systolic blood pressure, the diastolic blood pressure, the average blood pressure and the pulse pressure difference data in one average cardiac cycle are calculated and stored every minute.
Preferentially, the ultrasonic blood pressure regulation and control module realizes automatic regulation of blood pressure according to the change of real-time blood pressure monitoring data, and specifically comprises the following steps:
the second ultrasonic probe array of the ultrasonic blood pressure regulation and control module receives the instruction of the main control circuit module transmitted by the wireless communication module, starts the switch driving circuit, and transmits focused ultrasound to the stimulation target position according to the optimized stimulation parameters (ultrasonic focus position, ultrasonic intensity, stimulation duty ratio, pulse duration, ultrasonic frequency and the like) regulated by feedback, so as to realize blood pressure regulation and control.
Preferably, the temperature control module comprises a flexible electronic refrigeration sheet array, the flexible electronic refrigeration sheet array comprises a cold end and a hot end, and the cold end and the hot end are connected in series through a flexible lead.
Preferably, the first ultrasonic probe array and the second ultrasonic probe array are adjacent and are encapsulated by a flexible substrate.
Preferably, the temperature detection module comprises a flexible temperature sensor array.
Preferentially, the first ultrasonic probe array and the second ultrasonic probe array are embedded in the flexible patch, and the flexible temperature sensor array is respectively attached to the side surfaces of the first ultrasonic probe array and the second ultrasonic probe array; the cold ends of the flexible electronic refrigeration sheet arrays are respectively attached and fixed to the lower surfaces of the first ultrasonic probe array and the second ultrasonic probe array; the hot ends of the flexible electronic refrigeration sheet arrays are respectively attached and fixed on the upper surfaces of the first ultrasonic probe array and the second ultrasonic probe array.
The invention has the advantages that:
the invention provides a wearable automatic ultrasonic blood pressure detection and adjustment integrated system capable of controlling temperature, which can monitor blood pressure in real time, regulate and control the blood pressure by using low-intensity focused ultrasound when the value of the detected blood pressure is higher than a specific threshold value according to the change of real-time blood pressure monitoring data, realize the automatic maintenance of the stability of the blood pressure, monitor the temperature of an ultrasonic probe in real time, automatically start a refrigeration protection circuit when the temperature of the probe is overhigh, reduce the surface temperature of the probe, achieve the effects of safely and effectively regulating the blood pressure, providing comfortable and constant-temperature use feeling for a user and prolonging the service life of the wearable system.
Drawings
FIG. 1 is a schematic structural view of a wearable automatic ultrasound blood pressure monitoring and adjusting system with temperature control according to the present invention;
FIG. 2 is a flow chart of the ultrasonic blood pressure detection and automatic adjustment according to the embodiment of the present invention;
FIG. 3 is a flow chart of temperature detection and automatic cooling and temperature control of an ultrasonic probe according to an embodiment of the present invention;
fig. 4 is a schematic bottom view of a flexible temperature sensor array and a flexible electronic refrigeration sheet array in a flexible patch type ultrasonic probe array coverage manner according to an embodiment of the present invention;
fig. 5 is a schematic top view of a flexible temperature sensor array and a flexible electronic refrigeration sheet array in a flexible patch type ultrasonic probe array coverage manner according to an embodiment of the present invention.
Reference numbers in the figures: 1. a flexible temperature sensor array; 2. a cold end; 3. an ultrasonic blood pressure detection module; 41. a first ultrasound probe array; 42. a second ultrasound probe array; 5. an ultrasonic blood pressure regulation module; 6. a flexible patch; 7. a hot end.
Detailed Description
In order to make the objects, technical solutions and advantages of the embodiments of the present invention more apparent, the technical solutions of the embodiments of the present invention will be described clearly and completely with reference to the accompanying drawings of the embodiments of the present invention, and it is obvious that the described embodiments are some, but not all embodiments of the present invention. All other embodiments, which can be obtained by a person skilled in the art without any inventive step based on the embodiments of the present invention, are within the scope of the present invention. Thus, the following detailed description of the embodiments of the present invention, presented in the figures, is not intended to limit the scope of the invention, as claimed, but is merely representative of selected embodiments of the invention.
As shown in fig. 1, a wearable ultrasound blood pressure detecting and adjusting integrated system with controllable temperature comprises: the ultrasonic probe temperature control system comprises an ultrasonic transmitting module based on a flexible patch type ultrasonic probe array, an ultrasonic probe temperature detection module based on a flexible temperature sensor array 1, an ultrasonic probe temperature control module based on a flexible electronic refrigerating sheet array, a main control circuit module, a wireless communication module, a display module and a power supply module. Wherein:
the ultrasonic transmitting module is used for generating and transmitting ultrasonic energy and can be well attached to the skin of a human body. The module comprises two sub-modules, an ultrasonic blood pressure detection module 3 and an ultrasonic blood pressure regulation and control module 5 based on a patch type ultrasonic probe array.
Specifically, the working flows of the ultrasonic blood pressure detection module 3 and the ultrasonic blood pressure regulation and control module 5 according to the embodiment of the present invention are shown in fig. 2.
The ultrasonic blood pressure detection module 3 carries out artery blood vessel positioning and real-time monitoring of artery blood pressure by using Doppler ultrasound; the ultrasonic blood pressure regulation and control module 5 stimulates a peripheral nerve (such as a cervical vagus nerve) or a carotid sinus baroreceptor by using low-intensity focused ultrasound when detecting that the blood pressure value is higher than a specific threshold value according to the change of real-time blood pressure monitoring data, so as to realize automatic regulation of the blood pressure. The first ultrasonic probe array 41 of the ultrasonic blood pressure detection module 3 can continuously measure the arterial blood pressure waveform, and calculate and store the data of systolic blood pressure, diastolic blood pressure, mean blood pressure, pulse pressure difference and the like in an average cardiac cycle every minute; the blood pressure data detected by the second ultrasonic probe array 42 of the ultrasonic blood pressure detection module 3 is wirelessly transmitted to the main control circuit module for data processing, and the display module displays the blood pressure value monitored in real time; the flexible ultrasonic probe array of the ultrasonic blood pressure regulation and control module 5 receives the instruction of the main control circuit module transmitted by the wireless communication module, starts the switch driving circuit, and transmits focused ultrasound to the stimulation target position according to the optimized stimulation parameters (ultrasonic focus position, ultrasonic intensity, stimulation duty ratio, pulse duration, ultrasonic frequency and the like) regulated by feedback, so as to realize blood pressure regulation and control. The first ultrasonic probe array 41 and the second ultrasonic probe array 42 are both flexible patch 6 type.
Specifically, the flow of the temperature detection and the automatic cooling and temperature control of the ultrasonic probe according to the embodiment of the present invention is shown in fig. 3.
The temperature detection module comprises a flexible temperature sensor array 1 and is used for monitoring the surface temperature of the ultrasonic probe in real time. The flexible temperature sensor array 1 can be well attached to the surfaces of the flexible patch 6 type ultrasonic probe array sides (the first ultrasonic probe array 41 and the second ultrasonic probe array 42), measured data are transmitted to the main control circuit module through wireless transmission to be processed, and the real-time monitored ultrasonic probe surface temperature value is displayed through the display module.
And the temperature control module is used for controlling the surface temperature of the ultrasonic probe in real time. The flexible electronic refrigeration piece array is utilized, the integrated semiconductor refrigeration film is packaged by the flexible substrate, when the surface temperature of the ultrasonic probe exceeds a specific threshold value, the instruction of the main control circuit module transmitted by the wireless communication module is received, the switch driving circuit is started, and the ultrasonic probe array is refrigerated and cooled.
The main control circuit module is used for receiving monitoring data such as blood pressure, temperature and the like, processing the data and outputting a control instruction, and comprises a main control circuit and a switch driving circuit. According to the change of the monitored blood pressure value, when the blood pressure value exceeds a set specific blood pressure threshold value, different stimulation parameters such as an ultrasonic focus position, ultrasonic intensity, stimulation duty ratio, pulse duration, ultrasonic frequency and the like are adjusted, an optimized stimulation mode is automatically switched, a blood pressure regulation and control instruction is output, a switch driving circuit is started, and a flexible ultrasonic probe array is driven to work; according to the change of the monitored temperature value, when the temperature value exceeds a set specific temperature threshold value, the optimal temperature control parameter is adjusted, a temperature control instruction is output, and a switch driving circuit is started to drive the flexible electronic refrigerating sheet to work. And the power supply module is arranged in the control module and provides a portable chargeable power supply for the wearable integrated system.
And the wireless communication module is used for transmitting signals and monitoring data and wirelessly transmitting the monitoring data with the main control circuit module. The wireless communication module is arranged in the shell of the first ultrasonic probe array 41 and the second ultrasonic probe array 42.
And the display module is used for displaying the blood pressure and temperature values monitored in real time.
Specifically, the schematic diagram of the flexible temperature sensor array 1 and the flexible electronic refrigeration sheet array at the bottom of the flexible patch 6 type ultrasonic probe array coverage mode is shown in fig. 4, and the schematic diagram of the top is shown in fig. 5, specifically: the ultrasonic blood pressure detection module 3 and the ultrasonic blood pressure regulation and control module 5 are embedded in the flexible patch 6, and the flexible temperature sensor array 1 is respectively attached to the side surfaces of the first ultrasonic probe array 41 and the second ultrasonic probe array 42; the cold ends 2 of the flexible electronic refrigeration sheet arrays are attached and fixed to the lower surfaces of the first ultrasonic probe array 41 and the second ultrasonic probe array 42; the hot end 7 of the flexible electronic refrigeration sheet array is attached and fixed on the upper surfaces of the first ultrasonic probe array 41 and the second ultrasonic probe array 42.
Specifically, the ultrasonic blood pressure detection module 3 comprises two adjacent rows of micro ultrasonic probe linear arrays which are formed by packaging flexible substrates, each ultrasonic probe array comprises 1 or more micro ultrasonic probes, and each micro ultrasonic probe is internally provided with an integrated micro ultrasonic signal generator and a micro power amplifier;
the first ultrasonic probe array 41 of the ultrasonic blood pressure detection module 3 is attached to the carotid artery;
the second ultrasonic probe array 42 of the ultrasonic blood pressure regulation and control module 5 is attached to the position of the cervical vagus nerve or the carotid sinus; each flexible ultrasonic probe array can be positioned and adjusted based on ultrasonic imaging; the flexible substrate of the probe array is made of one or more of polyimide, polyester film and the like.
Specifically, the flexible temperature sensor array 1 comprises an upper layer flexible substrate and a lower layer flexible substrate, wherein an upper electrode and a lower electrode are respectively distributed on the upper layer flexible substrate and the lower layer flexible substrate, and a flexible temperature-sensitive insulating layer is distributed between the upper layer substrate and the lower layer substrate. The upper and lower flexible substrates of the sensor array adopt one or more of materials such as polyimide, polyester film and the like; the upper electrode and the lower electrode are made of one or more metal materials, such as a metal silver electrode; the flexible temperature-sensitive insulating layer is made of one or more temperature-sensitive materials such as poly N-isopropyl acrylamide doped nano copper or nano materials; the electrode and the temperature-sensitive material can be realized in a 3D printing mode. The flexible temperature sensor array 1 is attached to the side surface of the flexible patch 6 type ultrasonic probe array. The flexible temperature sensor array 1 has the characteristics of full-flexible design, simple structure, easy size matching and fitting with the flexible patch 6 type ultrasonic probe array and the flexible electronic refrigerating sheet array, multipoint temperature measurement, large temperature measurement temperature range, high sensitivity and precision, quick thermal response, low manufacturing cost, simple preparation process, batch production and the like.
Specifically, the flexible electronic refrigeration sheet array comprises a cold end 2 and a hot end 7, wherein the cold end 2 refrigerates, the hot end 7 dissipates heat, and the cold end 2 and the hot end 7 are connected in series through a flexible lead; after the power is switched on, the refrigeration is carried out through the temperature difference effect of the semiconductor material. The flexible substrate of the electronic refrigeration sheet is made of one or more of polyimide, polyester film and the like. The hot end 7 of the flexible electronic refrigeration sheet is respectively attached and fixed on the upper surfaces of the first ultrasonic probe array 41 and the second ultrasonic probe array 42, and the cold end 2 is respectively attached and fixed on the lower surfaces of the first ultrasonic probe array 41 and the second ultrasonic probe array 42. The flexible electronic refrigeration chip array has the characteristics of small thermal inertia, short refrigeration time, small volume, no noise and strong stability.
The above description is only an embodiment of the present invention, and not intended to limit the scope of the present invention, and all equivalent structures or equivalent flow transformations made by using the contents of the specification and the drawings, or applied directly or indirectly to other related systems, are included in the scope of the present invention.
Claims (7)
1. The utility model provides a wearable supersound blood pressure of controllable temperature detects and adjusts integration system which characterized in that:
the ultrasonic temperature measurement device comprises a flexible patch (6), an ultrasonic transmitting module, a temperature detection module, a temperature control module, a main control circuit module, a wireless communication module, a display module and a power supply module; the ultrasonic transmitting module is arranged on the flexible patch (6), and the temperature detecting module is arranged on the ultrasonic transmitting module;
the ultrasound transmission module comprises two sub-modules: an ultrasonic blood pressure detection module (3) and an ultrasonic blood pressure regulation module (5);
the ultrasonic blood pressure detection module (3) and the ultrasonic blood pressure regulation and control module (5) respectively comprise a first ultrasonic probe array (41) and a second ultrasonic probe array (42);
the ultrasonic blood pressure detection module (3) is used for positioning arterial blood vessels and monitoring arterial blood pressure in real time;
the ultrasonic blood pressure regulation and control module (5) realizes automatic regulation of blood pressure according to the change of real-time blood pressure monitoring data;
the temperature detection module is used for monitoring the surface temperature of the ultrasonic probes of the ultrasonic blood pressure detection module (3) and the ultrasonic blood pressure regulation and control module (5) in real time, the measured temperature data is transmitted to the main control circuit module through wireless transmission for processing, and the display module displays the surface temperature value of the ultrasonic probes monitored in real time;
the temperature control module is used for controlling the surface temperature of the first ultrasonic probe array (41) and the second ultrasonic probe array (42) in real time;
the main control circuit module comprises a main control circuit and a switch driving circuit; the ultrasonic blood pressure monitoring and controlling system is used for receiving monitoring data of blood pressure and temperature, outputting a blood pressure regulating and controlling instruction according to the change of the monitored blood pressure value, starting a switch driving circuit and driving a second ultrasonic probe array (42) of the ultrasonic blood pressure regulating and controlling module (5) to work; outputting a temperature control instruction according to the change of the monitored temperature value, starting a switch driving circuit, and driving a temperature control module to regulate the temperature;
the wireless communication module is used for transmitting signals and monitoring data and wirelessly transmitting the data with the main control circuit module;
the display module is used for displaying the blood pressure and temperature values monitored in real time;
and the power supply module is used for providing power supply.
2. The temperature-controllable wearable ultrasonic blood pressure detection and adjustment integrated system as claimed in claim 1,
the ultrasonic blood pressure detection module (3) is used for positioning arterial blood vessels and monitoring arterial blood pressure in real time, and specifically comprises the following steps:
the first ultrasonic probe array (41) of the ultrasonic blood pressure detection module (3) can continuously measure the arterial blood pressure waveform, and the systolic blood pressure, the diastolic blood pressure, the average blood pressure and the pulse pressure difference data in one average cardiac cycle are calculated and stored every minute.
3. The wearable temperature-controllable ultrasonic blood pressure detection and adjustment integrated system according to claim 1 or 2, characterized in that:
the ultrasonic blood pressure regulation and control module (5) realizes automatic regulation of blood pressure according to the change of real-time blood pressure monitoring data, and specifically comprises the following steps:
the second ultrasonic probe array (42) of the ultrasonic blood pressure regulation and control module (5) receives the instruction of the main control circuit module transmitted by the wireless communication module, starts the switch driving circuit, and transmits focused ultrasound to the stimulation target point position according to the optimized stimulation parameters adjusted by feedback, so as to realize blood pressure regulation and control.
4. The wearable ultrasound integrated blood pressure monitoring and adjustment system according to claim 3, wherein:
the temperature control module comprises a flexible electronic refrigeration piece array, the flexible electronic refrigeration piece array comprises a cold end (2) and a hot end (7), and the cold end (2) and the hot end (7) are connected in series through a flexible lead.
5. The wearable ultrasound integrated blood pressure monitoring and adjustment system according to claim 4, wherein:
the first ultrasonic probe array (41) and the second ultrasonic probe array (42) are adjacent and are formed by packaging flexible substrates.
6. The temperature-controllable wearable ultrasonic blood pressure detection and adjustment integrated system according to claim 5, characterized in that:
the temperature detection module comprises a flexible temperature sensor array (1).
7. The temperature-controllable wearable ultrasonic blood pressure detection and adjustment integrated system according to claim 6, characterized in that:
the ultrasonic blood pressure detection module (3) and the ultrasonic blood pressure regulation and control module (5) are embedded in the flexible patch (6), and the flexible temperature sensor array (1) is respectively attached to the side surfaces of the first ultrasonic probe array (41) and the second ultrasonic probe array (42); the cold ends (2) of the flexible electronic refrigeration sheet arrays are respectively attached and fixed to the lower surfaces of the first ultrasonic probe array (41) and the second ultrasonic probe array (42); the hot ends (7) of the flexible electronic refrigeration sheet arrays are respectively attached and fixed on the upper surfaces of the first ultrasonic probe array (41) and the second ultrasonic probe array (42).
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Cited By (1)
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