CN110860008A

CN110860008A - Infusion system and method

Info

Publication number: CN110860008A
Application number: CN201911356818.6A
Authority: CN
Inventors: 李海燕
Original assignee: Zhuhai Yingzhi Tech Co Ltd
Current assignee: Shenzhen Yingrui Biotechnology Co., Ltd
Priority date: 2019-11-04
Filing date: 2019-12-25
Publication date: 2020-03-06
Anticipated expiration: 2039-12-25
Also published as: CN110860008B; WO2021087654A1

Abstract

The invention discloses an infusion system and method, the system comprises a consumable structure and infusion equipment, the consumable structure comprises an infusion pipeline and at least two parallel-connected capsule cavities communicated with the infusion pipeline, each capsule cavity comprises an inner cavity used for containing infusion liquid, each inner cavity is a cavity formed by one or more elastic diaphragms and fixing structures of the elastic diaphragms, the infusion equipment comprises at least two linear motion devices, a driving controller used for driving the linear motion devices and a pressure detection device used for monitoring the pressure of the infusion liquid in real time, and the linear motion devices do linear motion along the axis direction of the capsule cavities and change the volume of the capsule cavities through elastic deformation so as to realize the suction or discharge of the infusion liquid. The method of the invention is applied to the infusion system. The invention can realize constant-speed infusion, has extremely small fluctuation, has no limitation of the total infusion amount of the injection component, and does not influence the accuracy of the infusion rate.

Description

Infusion system and method

[ technical field ] A method for producing a semiconductor device

The invention relates to the technical field of medical equipment, in particular to an infusion system and an infusion method applied to the system.

[ background of the invention ]

An infusion pump is a medical apparatus for infusion, and achieves the purpose of controlling the infusion amount or the medicine amount input to a recipient by controlling the infusion flow rate in an infusion catheter. Infusion pumps in clinical application at present are mainly classified into two types: one type is a disposable injection infusion pump or a syringe micro-injection infusion pump (hereinafter referred to as an "injection pump"), which generally adopts a motor to push a piston push rod of an injection component to perform linear motion through a transmission mechanism, so as to realize the suction and injection of infusion liquid, and has the advantages of realizing higher injection precision and more stable injection rate, and having the defects that the total amount of the infusion liquid is limited by the capacity of the injection component and cannot realize the constant-speed infusion liquid injection with large capacity; the other type of infusion pump is a pressure type infusion pump, which is also called a peristaltic control type infusion pump (hereinafter referred to as a peristaltic pump), and the pressure type infusion pump sequentially extrudes infusion hoses in a finger pressure peristaltic manner to push liquid medicine forward so as to realize the injection of infusion liquid.

Thus, infusion protocols that tightly control infusion rates or perform variable infusion rates have proven to be an important and effective clinical treatment modality.

Chinese patent application No. CN201510278762.2 discloses an infusion system, which includes at least two syringes, a first liquid inlet pipe 44, a second liquid inlet pipe 84, a first liquid outlet pipe 46, a second liquid outlet pipe 86, a liquid inlet 440 and a liquid outlet 442. The two injectors are a first injector 2 and a second injector 6, an injection port of the first injector 2 is communicated with a liquid inlet 440 through a first liquid inlet pipeline 44 and is communicated with a liquid outlet 442 through a first liquid outlet pipeline 46, and an injection port of the second injector 6 is communicated with the liquid inlet 440 through a second liquid inlet pipeline 84 and is communicated with the liquid outlet 442 through a second liquid outlet pipeline 86. The infusion system further comprises a first liquid inlet valve 40, a first liquid outlet valve 42, a second liquid inlet valve 80 and a second liquid outlet valve 82, wherein the first liquid inlet valve 40 is arranged on the first liquid inlet pipeline 44, the first liquid outlet valve 42 is arranged on the first liquid outlet pipeline 46, the second liquid inlet valve 80 is arranged on the second liquid inlet pipeline 84, and the second liquid outlet valve 82 is arranged on the second liquid outlet pipeline 86. The invention also discloses an infusion method adopting the infusion system. The infusion system and the infusion method of the invention have no limitation of the total infusion amount of the injection component, do not influence the accuracy of the infusion rate, can realize constant-speed infusion, and have extremely small fluctuation.

However, in this system, the injection port of the injection component and the liquid inlet pipeline and the liquid outlet pipeline connected with the injection port form a "T" type connection, so that when in use, a large volume of gas in the pipeline cannot be discharged. When infusion liquid is injected, the injection precision of the infusion liquid can be influenced, and meanwhile, if gas at the T-shaped connecting part enters the pipeline when infusion is injected, the risk when infusion liquid is injected can be increased.

Meanwhile, in the field of high-pressure infusion, such as contrast injection, the existing scheme mostly adopts a single or a plurality of high-capacity high-pressure injectors (200 ml and above), and the contrast is firstly sucked into the high-pressure injectors by a pushing motor and then is injected into the bodies of patients from the high-pressure injectors by the pushing motor. This procedure is required for each patient, increasing examination time and reducing examination efficiency.

Meanwhile, when a patient is examined, the contrast medium in the high-pressure injector can not be completely used, and the contrast medium is remained and can not be used for the second time, so that unnecessary economic burden and social burden of the patient are caused.

In addition, in some occasions with high infusion total amount and high infusion speed, such as clinical emergency, the infusion total amount of 6000ml per hour needs to be achieved, and the existing push type infusion pump and the peristaltic pump are difficult to meet the clinical use requirement.

[ summary of the invention ]

The invention mainly aims to provide an infusion system which has no limitation of the total infusion amount of a pushing component, does not influence the accuracy of the infusion rate, can realize constant-speed infusion and has extremely small fluctuation.

The invention also aims to provide an infusion method which has no limitation of the total infusion amount of a pushing injection part and no influence on the accuracy of the infusion rate, can realize constant-speed infusion and has extremely small fluctuation.

In order to achieve the main purpose, the infusion system provided by the invention comprises a consumable structure, wherein the consumable structure comprises an infusion pipeline and at least two parallel connected sac cavities communicated with the infusion pipeline, each sac cavity comprises an inner cavity for containing infusion liquid, and each inner cavity is a cavity formed by one or more elastic membranes and fixing structures of the elastic membranes; the infusion device comprises at least two linear motion devices, a driving controller used for driving the linear motion devices and a pressure detection device used for monitoring the pressure of infusion liquid in real time, wherein the linear motion devices do linear motion along the axis direction of the capsule cavity and change the volume of the capsule cavity through elastic deformation so as to realize the suction or discharge of the infusion liquid.

Therefore, the infusion system mainly comprises infusion equipment and a consumable structure matched with the infusion equipment, the infusion equipment is used for infusing at a preset rate through the mutual matching of the liquid inlet control valve, the liquid outlet control valve, the pressure head, the capsule cavity, the linear motion device, the driving controller and the pressure detection device, in addition, in the complete infusion process, the respective periods are in smooth transition, the defect that the total infusion amount of the injection pump is limited by the volume of an injection component is avoided, and the defect that the infusion flow rate of the peristaltic pump is in instantaneous pulsation is overcome.

Meanwhile, the requirements of high total infusion amount and high infusion speed can be met by designing different capsule cavity volumes and corresponding pressure head movement frequencies.

The liquid inlet control valve is arranged at one end, close to the liquid inlet, of the liquid inlet pipeline, and the liquid outlet control valve is arranged at one end, close to the liquid outlet, of the liquid outlet pipeline.

Therefore, the consumable matched with the equipment is mainly provided with two or more than two sac cavities which are connected in parallel, each sac cavity is provided with two interfaces for liquid inlet and liquid outlet, and infusion liquid can enter the sac cavity from a liquid inlet of the sac cavity and flow out of the sac cavity from a liquid outlet when the infusion liquid normally works by controlling the liquid inlet control valve and the liquid outlet control valve. And when the infusion bag does not work normally, the infusion liquid can be sucked back into the bag cavity from the liquid outlet of the bag cavity and discharged out of the bag cavity from the liquid inlet.

The liquid outlet pipeline is further connected with a filter, and the filter is used for filtering out bubbles and/or impurities of the infusion liquid output by the liquid outlet pipeline.

Therefore, the filter can filter bubbles and various impurities in the infusion liquid output by the liquid pipeline, so that high-efficiency and accurate filtration is realized, and the output infusion liquid meets the corresponding quality standard.

The further proposal is that the elastic membrane of the capsule cavity is connected with the linear motion device through a rigid structure.

In a further scheme, the linear motion device comprises a pressure head and a driving device for driving the pressure head, the driving controller is used for outputting a driving signal to the driving device, and the pressure head is in contact with the elastic diaphragm of the capsule cavity.

In a further aspect, a rigid structure is provided on the elastic membrane of the capsule and in proximity to the abutment with the pressure head, the rigid structure being made of magnetic material.

The rigid structure comprises a first buckling part arranged on the elastic diaphragm of the capsule cavity and a second buckling part arranged in the pressure head, and the first buckling part is connected with the second buckling part in a buckling mode.

Therefore, a rigid structure is designed on the elastic diaphragm of the capsule cavity, the rigid structure can be connected with a pressure head when the system works, and when the pressure head presses the elastic diaphragm, the capsule cavity discharges infusion liquid; when the pressure head moves reversely, the elastic membrane of the capsule cavity is connected with the pressure head together due to the rigid structure and pulled back by the pressure head, so that the resetting of the elastic membrane of the capsule cavity is accelerated, and the capsule cavity can be filled with infusion liquid more quickly, thereby meeting the requirement of high-speed or high-viscosity infusion liquid infusion.

The pressure detection device comprises at least two pressure sensors, wherein the first pressure sensor detects the pressure of the infusion liquid in the first capsule cavity and sends a first pressure detection signal to the driving controller, and the driving controller is further used for controlling the first driving device according to the first pressure detection signal and driving the first pressure head to move or stop moving; the second pressure sensor senses the pressure of the infusion fluid in the second bladder cavity and sends a second pressure sensing signal to the drive controller, and the drive controller is further configured to control the second drive device and drive the second ram to move or stop moving based on the second pressure sensing signal.

Therefore, the pressure sensor can monitor the infusion liquid pressure in the capsule cavity in real time and send a pressure detection signal to the driving controller, the driving controller compares the received pressure detection signal with the originally set preset pressure value, and when the pressure detection signal is greater than the preset pressure value, the driving controller controls the driving device to stop driving and controls the pressure head to stop moving.

In a further aspect, the infusion device further comprises a bubble sensor, the bubble sensor detects the size or the accumulated bubble volume of bubbles in the infusion liquid in the bladder cavity and sends a first bubble signal or a second bubble signal to the drive controller, and the drive controller is further configured to control the first drive device and/or the second drive device according to the first bubble signal and/or the second bubble signal and drive the first ram and/or the second ram to move or stop moving.

It can be seen that when the bubble signal is greater than the preset bubble value set by the driving controller, the driving controller controls the driving device to stop driving, controls the pressure head to stop moving, and controls the alarm device to send out an alarm signal.

Further, the infusion device further comprises: an input device for setting infusion parameters; a display device for outputting display information; alarm means for outputting an alarm signal; and the power supply device is used for outputting electric energy for the transfusion system.

It can be seen that the input device is responsible for setting specific infusion parameters, the display device is responsible for displaying parameters, working states, alarm information and the like, the alarm device can give out alarms including sounds, images, light and the like, and the power supply device can provide energy for the whole system.

In order to achieve the above another object, the present invention further provides an infusion method, comprising step S1, closing the first liquid inlet control valve, opening the first liquid outlet control valve, and simultaneously closing the second liquid inlet control valve and the second liquid outlet control valve, wherein the driving device drives the first pressure head to perform an extending motion at a predetermined rate, and presses the elastic membrane of the first bladder to deform so as to decrease the internal volume of the first bladder, so that the infusion liquid is discharged through the liquid outlet until the first pressure head moves to a maximum position, at which the internal volume of the first bladder is at a minimum; step S2, closing the second liquid inlet control valve, opening the second liquid outlet control valve, driving the second pressure head to extend at a preset speed by the driving device, extruding the elastic membrane of the second capsule cavity to deform to reduce the volume of the second capsule cavity, and discharging the infusion liquid through the liquid outlet until the second pressure head moves to the maximum position, wherein the volume of the second capsule cavity is minimum; step S3, closing the first liquid inlet control valve and opening the first liquid outlet control valve, wherein the first pressure head continues to perform extension movement at a preset speed and extrudes the elastic membrane of the first capsule cavity to deform so as to promote the reduction of the internal volume of the first capsule cavity, and the infusion liquid is discharged through the liquid outlet of the first capsule cavity until the first pressure head moves to the maximum position, at which time the internal volume of the first capsule cavity is minimum; step S4, repeating the step S2 and the step S3, so that the infusion system can perform infusion at a predetermined rate.

Further, after determining that the consumable structure is connected to the infusion device, step S0 is performed, wherein step S0 includes controlling the first fluid inlet control valve to close, the first fluid outlet control valve to open, the second fluid inlet control valve to open, and the second fluid outlet control valve to close, so as to cause the first and second bladders to be filled with the infusion fluid.

In a further embodiment, in step S1, when the first ram extends to the maximum position, that is, when the volume in the first bladder cavity reaches the minimum, the first fluid inlet control valve is controlled to open, the first fluid outlet control valve is controlled to close, the second fluid inlet control valve is controlled to close, the second fluid outlet control valve is controlled to open, and the first ram is controlled to reset to urge the elastic diaphragm of the first bladder cavity to deform due to elastic recovery, so that negative pressure is generated in the first bladder cavity due to elastic diaphragm deformation, and the infusion fluid is sucked into the first bladder cavity through the fluid inlet of the first bladder cavity.

In a further embodiment, in step S2, when the second ram is extended to the maximum position, that is, when the volume in the second bladder cavity reaches the minimum, the second fluid inlet control valve is controlled to open, the second fluid outlet control valve is controlled to close, the second ram is controlled to reset, the second bladder cavity generates negative pressure due to the elastic diaphragm of the second bladder cavity being restored to deform, and the infusion fluid is sucked into the second bladder cavity through the fluid inlet of the second bladder cavity.

Further, in the above steps S1, S3, the first pressure sensor of the pressure detection device monitors the pressure of the infusion liquid in the first capsule cavity in real time and sends a first pressure detection signal to the driving controller, when the first pressure detection signal is greater than a preset pressure value, the driving controller controls the first driving device and the second driving device to stop driving, and controls the first pressure head and the second pressure head to stop moving, and controls the alarm device to send an alarm signal; in the step S2, the pressure of the infusion liquid in the second sac is monitored in real time by the second pressure sensor of the pressure detection device, and a second pressure detection signal is sent to the driving controller, when the second pressure detection signal is greater than the preset pressure value, the driving controller controls the first driving device and the second driving device to stop driving, controls the first pressure head and the second pressure head to stop moving, and controls the alarm device to send out an alarm signal.

The infusion device further comprises a bubble sensor, wherein the bubble sensor detects the size or the accumulated bubble capacity of bubbles in the infusion liquid and sends a first bubble signal corresponding to the size of the bubbles or a second bubble signal corresponding to the accumulated bubble capacity to the drive controller; the driving controller receives the first bubble signal or the second bubble signal, when the first bubble signal or the second bubble signal is larger than a preset bubble value set by the driving controller, the driving controller controls the first driving device and the second driving device to stop driving, controls the first pressure head and the second pressure head to stop moving, and controls the alarm device to send out an alarm signal.

A rigid structure is arranged between the elastic membrane of the capsule cavity and the pressure head, when the system works, the rigid structure is rigidly connected with the pressure head, and when the pressure head presses the elastic membrane of the capsule cavity, the capsule cavity discharges infusion liquid; when the pressure head resets, the elastic membrane of the capsule cavity and the pressure head are connected into a whole through a rigid structure so as to enable the elastic membrane of the capsule cavity to be pulled back by the pressure head.

Therefore, the infusion method of the invention has the advantages that the liquid inlet control valve, the liquid outlet control valve, the pressure head, the capsule cavity, the linear motion device, the driving controller and the pressure detection device are matched with each other, so that the liquid outlet pipeline carries out infusion at a preset rate, in addition, in the complete infusion process, the respective periods are in smooth transition, the defect that the total infusion amount of the injection pump is limited by the volume of an injection part is avoided, and the defect that the infusion flow rate of the peristaltic pump is in instantaneous pulsation is overcome.

[ figure ] is illustrated

Fig. 1 is a schematic diagram of a first embodiment of an infusion system of the present invention.

Fig. 2 is a schematic structural diagram of a bladder cavity and a fluid outlet control valve in a first embodiment of an infusion system.

FIG. 3 is a schematic structural diagram of an infusion device and a consumable structure in an embodiment of an infusion system of the invention.

FIG. 4 is a schematic view of the fluid inlet line of an embodiment of the fluid delivery system of the present invention.

Fig. 5 is a diagram of an initial state of a ram and a bladder cavity in an embodiment of an infusion system.

Fig. 6 is a schematic view of a rigid structure in an embodiment of an infusion system.

Fig. 7 is a schematic structural view of a rigid structure in a second embodiment of an infusion system in accordance with the present invention.

Fig. 8 is a schematic structural view of a pressure head squeezing capsule in an embodiment of an infusion method of the invention.

FIG. 9 is a schematic diagram of a ram squeezing a bladder cavity in an embodiment of an infusion method of the invention.

FIG. 10 is a graph of infusion fluid flow rate versus time for a first ram motion squeeze in an embodiment of an infusion method of the present invention.

FIG. 11 is a graph of infusion fluid flow rate versus time for a first ram and a second ram co-operating to compress in one embodiment of an infusion method of the invention.

[ detailed description ] embodiments

In order to make the objects, technical solutions and advantages of the present invention more apparent, the present invention is further described in detail below with reference to the drawings and examples. It should be understood that the specific embodiments described herein are merely illustrative of the invention and are not limiting of the invention.

An embodiment of a fluid delivery system is as follows:

referring to fig. 1 to 4, an infusion system of the present invention includes a consumable structure 10 and an infusion device 20 used in cooperation with the consumable structure 10, where the consumable structure 10 includes an infusion pipeline and at least two parallel connected capsule cavities communicated with the infusion pipeline, each capsule cavity includes an inner cavity for containing infusion liquid, and the inner cavity is a cavity formed by one or more elastic membranes and a fixing structure of the elastic membranes, such as the fixing structure 181 of the elastic membrane 18 of the first capsule 14. The infusion pipeline comprises a liquid inlet pipeline and a liquid outlet pipeline, the inner cavity of each sac cavity is provided with a liquid inlet communicated with the liquid inlet pipeline and a liquid outlet communicated with the liquid outlet pipeline, a liquid inlet control valve is arranged at one end, close to the liquid inlet, of the liquid inlet pipeline, and a liquid outlet control valve is arranged at one end, close to the liquid outlet, of the liquid outlet pipeline, so that infusion liquid can only flow in a single direction. The infusion system of the present embodiment may be used in the field of high pressure infusion, such as contrast media injection.

In this embodiment, the consumable structure 10 has a first capsule 14 and a second capsule 15 connected in parallel, the first capsule 14 and the second capsule 15 have the same structure, taking the first capsule 14 as an example: the first cavity 14 has a cylindrical hollow structure, a liquid inlet and a liquid outlet are formed on the side surface of the cylindrical hollow structure, and a first elastic membrane 18 is formed on one side plane of the cylindrical hollow structure.

Wherein, the liquid inlet of the first capsule cavity 14 is connected with a first liquid inlet control valve 16, the liquid outlet thereof is connected with a first liquid outlet control valve 12, the liquid inlet of the second capsule cavity 15 is connected with a second liquid inlet control valve 17, the liquid outlet thereof is connected with a second liquid outlet control valve 13, the first capsule cavity 14 and the second capsule cavity 15 are connected in parallel, and the liquid outlet pipeline is connected with a filter 11, and the filter 11 is used for filtering bubbles and/or impurities in the infusion liquid output by the liquid outlet pipeline.

Specifically, the consumable structure 10 has two or more than two bladder cavities connected in parallel, each bladder cavity has two ports for liquid inlet and outlet, the liquid inlet is connected with a liquid inlet control valve, the liquid outlet is connected with a liquid outlet control valve, and infusion liquid can enter the bladder cavity from the liquid inlet of the bladder cavity and flow out of the bladder cavity from the liquid outlet by controlling the liquid inlet control valve and the liquid outlet control valve during normal operation; when the infusion bag is not normally operated, the infusion liquid can be sucked back into the bag cavity from the liquid outlet of the bag cavity and discharged out of the bag cavity from the liquid inlet. Preferably, in this embodiment, the liquid inlet control valve and the liquid outlet control valve may adopt a one-way valve, so that the infusion liquid flows from the liquid inlet to the liquid outlet only in one way, which has a lower cost and reduces the burden on the patient and the social burden.

At the same time, the structure of the capsule has at least one elastic membrane, such as a first elastic membrane 18 and/or a second elastic membrane 19.

Meanwhile, the liquid inlet of the first capsule cavity 14 and the liquid inlet of the second capsule cavity 15 are provided with the same liquid inlet pipeline, and the liquid outlet of the first capsule cavity 14 and the liquid outlet of the second capsule cavity 15 are provided with the same liquid outlet pipeline.

In this embodiment, the feed liquor end of liquid inlet pipeline is connected with at least one bottle of reagent bottle, provides infusion liquid by the reagent bottle, is convenient for change and quantitative use, has made things convenient for user's nimble operation.

In the present embodiment, the infusion apparatus 20 includes at least two linear motion devices, a driving controller 25 for driving the linear motion devices, and a pressure detecting device for monitoring the pressure of the infusion liquid in real time, and the linear motion devices perform linear motion along the axial direction of the capsule and change the volume of the capsule by elastic deformation to realize the suction or discharge of the infusion liquid.

The elastic diaphragm of the capsule cavity is connected with the linear motion device through a rigid structure, for example, the elastic diaphragm 18 of the first capsule cavity 14 is connected with the first linear motion device through a rigid structure 43, and the elastic diaphragm 19 of the second capsule cavity 15 is connected with the second linear motion device through a rigid structure (not shown). It can be seen that a rigid structure 43 is designed on the elastic membrane 18 of the capsule 14, which rigid structure can be connected to the first pressure head 21 of the first linear motion device during operation of the system, when the pressure head 21 presses the elastic membrane 18, the capsule 14 is drained of infusion liquid; when the pressure head 21 moves reversely, the elastic membrane 18 of the capsule 14 and the pressure head 21 are connected together due to the rigid structure 43 and pulled back by the pressure head 21, so that the resetting of the elastic membrane 18 of the capsule 14 is accelerated, the capsule 14 can be filled with infusion liquid more quickly, and the requirement of high-speed or high-viscosity infusion liquid infusion is met.

Certainly, when large-flow infusion or high-viscosity infusion liquid is not needed, a rigid structure is not needed to be arranged on the elastic diaphragm of the capsule cavity, and a single elastic diaphragm structure can be adopted; if the requirement of large-flow infusion or high-viscosity infusion liquid exists, a mode of adding a rigid structure on the elastic diaphragm can be adopted, and the specific structure can be designed according to the requirement of a user.

Specifically, the linear motion device comprises a pressure head and a driving device for driving the pressure head, the driving controller 25 is used for outputting a driving signal to the driving device, and the pressure head is in contact with the elastic diaphragm of the capsule cavity. It can be seen that the linear motion device has two or more pressing heads with specific shapes, when the infusion device 20 is connected to the consumable structure 10, the first pressing head 21 and the second pressing head 22 are respectively in contact with the first elastic membrane 18 of the first capsule 14 and the second elastic membrane 19 of the second capsule 15, and the first pressing head 21 and the second pressing head 22 can be independently controlled to move or stop moving. Preferably, the first press head 21 and the second press head 22 have a ball-top cylindrical structure.

During operation, as shown in fig. 5, the consumable structure 10 is first connected and fixed with the infusion device 20, and the infusion pipeline is filled with air and infusion liquid, at this time, the spherical top end surface of the first pressure head 21 of the infusion device 20 contacts with the first elastic membrane 18 of the first capsule cavity 14 of the consumable structure 10, the spherical top end surface of the second pressure head 22 of the infusion device 20 contacts with the second elastic membrane 19 of the second capsule cavity 15 of the consumable structure 10, and the movement of the pressure head is a linear reciprocating movement coinciding with the axial center direction of the cylindrical capsule cavity structure.

Wherein the pressure detecting device comprises at least two pressure sensors, the first pressure sensor 27 detects the pressure of the infusion liquid in the first capsule 14 and sends a first pressure detecting signal to the driving controller 25, and the driving controller 25 is further configured to control the first driving device 23 according to the first pressure detecting signal and drive the first pressure head 21 to move or stop moving; the second pressure sensor 28 senses the pressure of the infusion fluid in the second capsule 15 and sends a second pressure sensing signal to the drive controller 25. the drive controller 25 is further configured to control the second driving device 24 and to drive the second ram 22 to move or stop moving based on the second pressure sensing signal.

Further, the infusion device 20 further comprises a bubble sensor 26, the bubble sensor 26 detects the size or the accumulated bubble volume of the bubbles in the infusion liquid in the sac chamber and sends a first bubble signal or a second bubble signal to the drive controller 25, and the drive controller 25 is further configured to control the first drive device 23 and/or the second drive device 24 according to the first bubble signal and/or the second bubble signal and drive the first ram 21 and/or the second ram 22 to move or stop moving.

Furthermore, a filter 11 is connected to the outlet line, and the filter 11 is used for filtering out bubbles and/or impurities of the infusion liquid output by the outlet line.

In this embodiment, the infusion device 20 further comprises: an input device 29 for setting infusion parameters; a display device 30 for outputting display information; an alarm device 32 for outputting an alarm signal; a power supply unit 31 for outputting electrical energy to the infusion system. It can be seen that the input device 29 is responsible for setting specific infusion parameters, the display device 30 is responsible for displaying parameters, working conditions, alarm information and the like, and an LED nixie tube and a liquid crystal display are mostly adopted, the alarm device 32 can give out an alarm including sound, images, light or the like, and the power supply device 31 can provide energy for the whole system.

Therefore, when it is determined that consumable structure 10 and infusion apparatus 20 are connected, after the infusion line is filled with infusion liquid, the bladder cavity is filled with infusion liquid by controlling the liquid inlet control valve and the liquid outlet control valve, and the infusion liquid is sucked or discharged by linearly moving the bladder cavity along the axial direction of the bladder cavity by the linear moving device and changing the volume of the bladder cavity by elastic deformation.

Because the infusion liquid enters the capsule cavity through the elastic membrane of the capsule cavity under the action of negative pressure generated during elastic reset, the membrane needs to be reset quickly in certain special occasions such as high-speed infusion, but the reset is slow due to insufficient elasticity of the membrane, so that the requirement of high-speed infusion cannot be met.

As shown in fig. 6, a rigid structure 43 is provided on the elastic membrane 18 of the capsule 14 and close to the abutment with the pressure head 21, the rigid structure 43 being made of magnetic material. In the present embodiment, the elastic membrane 18 of the capsule 14 has a rigid structure 43 thereon, the rigid structure 43 may be made of a magnetic material, and the pressure head 21 may be made of a permanent magnet or an electromagnet. During normal operation of the system, the rigid structure 43 on the flexible diaphragm 18 and the pressure head 21 are magnetically connected together, and when the pressure head 21 presses against the flexible diaphragm 18, the volume of the capsule 14 is reduced, and the infusion liquid is discharged. When the pressure head 21 is moved in the opposite direction, the rigid structure 43 of the elastic diaphragm 18, which is magnetically connected to the pressure head 21, is reset together with the pressure head 21, so that the infusion liquid can be quickly filled in the capsule 14.

An embodiment two of the transfusion system:

the rigid structure shown in fig. 7 comprises a first snap part 53 provided on the elastic membrane 51 of the capsule 52 and a second snap part 54 provided inside the pressure head 50, the first snap part 53 being snap connected with the second snap part 54. In this embodiment, the elastic diaphragm 51 has a rigid structure with at least one snap, and the ram 50 has a structure that fits the snap.

Before the system is operated, the first catch member 53 on the flexible diaphragm 51 can be manually or automatically connected to the second catch member 54 in the ram 50.

When the ram 50 presses against the flexible diaphragm 51 during operation of the system, the volume of the bladder cavity 52 is reduced and the infusion liquid is expelled. When the pressure head 50 moves in the opposite direction, the rigid structure of the elastic diaphragm 51, which is connected with the pressure head 50 by a snap fit, is reset together with the pressure head 50, so that the infusion liquid can be rapidly filled in the capsule 52.

After the system is operated, the first snap part 53 and the second snap part 54 of the ram 50 can be disengaged manually or automatically.

Therefore, the infusion system mainly comprises an infusion device 20 and a consumable structure 10 matched with the infusion device, wherein the infusion device is matched with a liquid inlet control valve, a liquid outlet control valve, a pressure head, a bag cavity, a linear motion device, a driving controller and a pressure detection device to enable a liquid outlet pipeline to conduct infusion at a preset rate, in addition, in the complete infusion process, the respective periods are in smooth transition, the defect that the total infusion amount of an injection pump is limited by the volume of an injection component is avoided, and the defect that the infusion flow rate of a peristaltic pump is in instantaneous pulsation is overcome.

When the high-pressure injection device is applied to the field of high-pressure infusion (such as contrast agent injection), the contrast agent in the high-pressure injector can be completely used, no residue is generated, the high-pressure injection device can be used for the second time, and unnecessary economic burden and social burden of a patient are reduced.

An embodiment of an infusion method comprises the following steps:

the infusion method is applied to the infusion system shown in the figures 1 to 7. The method comprises the following steps: first, step S1 is executed, the first liquid inlet control valve 16 is closed, the first liquid outlet control valve 12 is opened, and the second liquid inlet control valve 17 and the second liquid outlet control valve 13 are closed at the same time, the driving device drives the first pressure head 21 to perform an extending motion at a predetermined rate, and the elastic membrane of the first capsule 14 is pressed to deform so as to cause the internal volume of the first capsule 14 to decrease, and the infusion liquid is discharged through the liquid outlet thereof until the first pressure head 21 moves to a maximum position, at which the internal volume of the first capsule 14 is at a minimum.

Then, step S2 is executed to close the second liquid inlet control valve 17 and open the second liquid outlet control valve 13, the second ram 22 is driven by the driving device to perform an extending motion at a predetermined rate, and the elastic membrane of the second capsule 15 is pressed to deform so as to cause the internal volume of the second capsule 15 to decrease, and the infusion liquid is discharged through the liquid outlet until the second ram 22 moves to the maximum position, at which the internal volume of the second capsule 15 is at a minimum.

Next, step S3 is executed, the first liquid inlet control valve 16 is closed, the first liquid outlet control valve 12 is opened, the first pressure head 21 continues to perform the extending movement at the predetermined speed, and the elastic membrane of the first capsule 14 is pressed to deform so as to cause the internal volume of the first capsule 14 to decrease, and the infusion liquid is discharged through the liquid outlet thereof until the first pressure head 21 moves to the maximum position, at which the internal volume of the first capsule 14 is at a minimum.

Then, step S4 is executed, and the steps S2 and S3 are repeated, so that the infusion system can infuse at a predetermined rate.

After determining that consumable structure 10 is connected to infusion device 20, step S0 is further performed, and step S0 includes controlling first fluid inlet control valve 16 to close, first fluid outlet control valve 12 to open, second fluid inlet control valve 17 to open, and second fluid outlet control valve 13 to close, so as to cause first capsule 14 and second capsule 15 to be filled with infusion fluid.

In step S1, when the first ram 21 is extended to the maximum position, that is, when the volume in the first bladder cavity 14 reaches the minimum, the first liquid inlet control valve 16 is controlled to be opened, the first liquid outlet control valve 12 is controlled to be closed, the second liquid inlet control valve 17 is controlled to be closed, the second liquid outlet control valve 13 is controlled to be opened, and the first ram 21 is controlled to be reset to urge the elastic diaphragm of the first bladder cavity 14 to deform due to elastic recovery, so that negative pressure is generated in the first bladder cavity 14 due to elastic diaphragm deformation, and the infusion liquid is sucked into the first bladder cavity 14 through the liquid inlet of the first bladder cavity 14.

In step S2, when the second ram 22 is extended to the maximum position, that is, when the volume in the second capsule 15 reaches the minimum, the second liquid inlet control valve 17 is controlled to open, the second liquid outlet control valve 13 is controlled to close, the second ram 22 is controlled to reset, the second capsule 15 generates negative pressure due to the elastic diaphragm of the second capsule, and the infusion liquid is sucked into the second capsule 15 through the liquid inlet of the second capsule 15.

In the above steps S1 and S3, the pressure of the infusion liquid in the first capsule 14 is monitored in real time by the first pressure sensor 27 of the pressure detection device, and a first pressure detection signal is sent to the driving controller 25, when the first pressure detection signal is greater than a preset pressure value, the driving controller 25 controls the first driving device 23 and the second driving device 24 to stop driving, and controls the first ram 21 and the second ram 22 to stop moving, and controls the alarm device 32 to send out an alarm signal.

In the above step S2, the second pressure sensor 28 of the pressure detection device monitors the pressure of the infusion liquid in the second capsule 15 in real time and sends a second pressure detection signal to the driving controller 25, and when the second pressure detection signal is greater than the preset pressure value, the driving controller 25 controls the first driving device 23 and the second driving device 24 to stop driving, and controls the first ram 21 and the second ram 22 to stop moving, and controls the alarm device 32 to send an alarm signal.

The infusion device 20 further comprises a bubble sensor 26, the bubble sensor 26 detecting a bubble size or an accumulated bubble volume in the infusion liquid and sending a first bubble signal corresponding to the bubble size or a second bubble signal corresponding to the accumulated bubble volume to the drive controller 25; the driving controller 25 receives the first bubble signal or the second bubble signal, when the first bubble signal or the second bubble signal is greater than the preset bubble value set by the driving controller 25, the driving controller 25 controls the first driving device 23 and the second driving device 24 to stop driving, controls the first ram 21 and the second ram 22 to stop moving, and controls the alarm device 32 to send out an alarm signal.

In the present embodiment, a rigid structure 43 is provided between the elastic diaphragm 18 of the capsule 14 and the pressure head 21, the rigid structure 43 is rigidly connected with the pressure head 21 when the system is in operation, and the capsule 14 discharges the infusion liquid when the pressure head 21 presses the elastic diaphragm 18 of the capsule 14; when the pressure head 21 is reset, the elastic membrane 18 of the capsule 14 and the pressure head 21 are connected into a whole through the rigid structure 43, so that the elastic membrane 18 of the capsule 14 is pulled back by the pressure head 21, the resetting of the elastic membrane 18 of the capsule 14 is accelerated, the capsule 14 can be filled with infusion liquid more quickly, and the requirement of high-speed or high-viscosity infusion liquid infusion is met.

In practice, the consumable structure 10 is first connected to the infusion device 20, the infusion liquid is prepared, and the infusion line is filled with the infusion liquid.

Then, the first liquid inlet control valve 16 is closed, the first liquid outlet control valve 12 is opened, the second liquid inlet control valve 17 is opened, and the second liquid outlet control valve 13 is closed. At this time, both the first and

second lumens

14 and 15 are filled with infusion liquid.

Next, the first step is performed, closing the first liquid inlet control valve 16, and opening the first liquid outlet control valve 12, and simultaneously closing the second liquid inlet control valve 17 and the second liquid outlet control valve 13. The first driving device 23 drives the first pressing head 21 to perform an extending motion at a certain speed and press the first elastic diaphragm 18 of the first capsule 14, so that the infusion liquid in the first capsule 14 is discharged from the capsule liquid outlet due to the pressing effect of the first pressing head 21 until the extending motion of the first pressing head 21 is operated to the farthest (maximum) position, at which the internal volume of the first capsule 14 is at the minimum.

Then, the second step is executed, the second liquid inlet control valve 17 is closed, the second liquid outlet control valve 13 is opened, the second driving device 24 controls the second pressure head 22 to make an extending movement at a certain speed, and presses the second elastic diaphragm 19 of the second capsule cavity 15, and the infusion liquid in the second capsule cavity 15 is discharged from the capsule cavity liquid outlet due to the pressing effect of the second pressure head 22; when the second ram 22 is operated to the maximum position, i.e. when the volume in the second capsule 15 is at its minimum.

At the same time when the second step is started, that is, when the extending action of the first pressure head 21 is operated to the maximum position, the first liquid outlet control valve 12 is closed, the first liquid inlet control valve 16 is opened, the first pressure head 21 is controlled to reset, the first elastic diaphragm 18 is deformed due to elastic recovery, negative pressure is generated in the first capsule cavity 14 due to the deformation recovery of the first elastic diaphragm 18, and the infusion liquid is sucked into the first capsule cavity 14 through the liquid inlet.

Then, a third step is executed, closing the first liquid inlet control valve 16 and opening the first liquid outlet control valve 12, the first driving device 23 drives the first pressing head 21 to continue to perform the extending movement at the predetermined rate and press the first elastic diaphragm 18 of the first capsule 14, the first elastic diaphragm 18 deforms, the internal volume of the first capsule 14 decreases, and the infusion liquid is discharged through the liquid outlet until the first pressing head 21 moves to the farthest (maximum) position, at which the internal volume of the first capsule 14 is at a minimum.

At the same time of starting the third step, the second liquid outlet control valve 13 is closed, the second liquid inlet control valve 17 is opened, the second pressure head 22 is reset, the second elastic diaphragm 19 is reset due to the elasticity thereof, negative pressure is generated in the second capsule cavity 15, and infusion liquid is sucked into the second capsule cavity 15 through the liquid inlet due to the action of the negative pressure.

Thus, the second step and the third step are repeated continuously, namely, the change rate of the volume and the time in the first capsule 14 and/or the second capsule 15 can be controlled by controlling the extension rate of the first pressure head 21 and/or the second pressure head 22, so that an infusion scheme of strictly controlling the infusion rate or executing variable infusion rate can be performed, in addition, the respective periods are smoothly transited in the whole infusion process, the defect that the total infusion amount of the injection pump is limited by the volume of a bolus injection part can be avoided, and the defect that the infusion flow rate of the peristaltic pump is instantaneously pulsed is overcome.

In particular, the rate of return of the first ram 21 and/or the second ram 22 is greater than or equal to the rate of extension to ensure that the second capsule 15 (or the first capsule 14) has sufficient time to fill the entire capsule with infusion liquid when the first capsule 14 (or the second capsule 15) is drained.

Specifically, in the principle of the ram of the present embodiment (illustrated by the movement of the first ram 21), as shown in fig. 8 and 9, when the first ram 21 is operated to a certain position, the internal volume 140 of the first capsule 14 is the volume of the cylindrical space in the capsule minus the volume of the spherical pyramid formed by the deformation of the first elastic diaphragm 18 by the first ram 21, such as: v ═ f (x).

And the volume V gradually decreases as the displacement x of the first ram 21 gradually increases; by controlling the change in displacement x, the volume V can be made to vary in direct proportion, i.e. the infusion liquid is expelled at a constant rate; the infusion liquid flow rate time curve for the first ram 21 movement alone is shown in figure 10.

Similarly, when the first ram 21 and the second ram 22 are operated in concert as desired, the flow rate of the infusion liquid is plotted against time, as shown in fig. 11. The system can be caused to infuse at a predetermined constant rate and with smooth transitions of the respective periods during the complete infusion.

Further, the movement of the first ram 21 and/or the second ram 22 may be driven by a stepper motor.

It should be noted that the above is only a preferred embodiment of the present invention, but the design concept of the present invention is not limited thereto, and any insubstantial modifications made by using the design concept also fall within the protection scope of the present invention.

Claims

1. An infusion system, comprising:

the consumable structure comprises an infusion pipeline and at least two parallel-connected capsule cavities communicated with the infusion pipeline, wherein each capsule cavity comprises an inner cavity for containing infusion liquid, and each inner cavity is a cavity formed by one or more elastic diaphragms and fixing structures of the elastic diaphragms;

the infusion device is matched with the consumable structure and comprises at least two linear motion devices, a driving controller and a pressure detection device, wherein the driving controller is used for driving the linear motion devices, the pressure detection device is used for monitoring the pressure of infusion liquid in real time, and the linear motion devices do linear motion along the axis direction of the capsule cavity and change the volume of the capsule cavity through elastic deformation so as to realize the suction or discharge of the infusion liquid.

2. The infusion system of claim 1, wherein:

the infusion pipeline includes inlet pipe way and drain pipe way, every the inner chamber of bag chamber all be equipped with inlet that the inlet pipe way communicates mutually, with the liquid outlet that the drain pipe way communicates mutually, the inlet pipe is equipped with into liquid control valve in the one end that is close to the inlet on the road, the drain pipe is equipped with out liquid control valve in the one end that is close to the liquid outlet on the road.

3. The infusion system of claim 2, wherein:

the liquid outlet pipeline is also connected with a filter, and the filter is used for filtering bubbles and/or impurities of the infusion liquid output by the liquid outlet pipeline.

4. The infusion system of claim 1, wherein:

the elastic membrane of the capsule cavity is connected with the linear motion device through a rigid structure.

5. The infusion system of claim 4, wherein:

the linear motion device comprises a pressure head and a driving device for driving the pressure head, the driving controller is used for outputting driving signals to the driving device, and the pressure head is in contact with the elastic diaphragm of the capsule cavity.

6. The infusion system of claim 5, wherein:

the rigid structure is arranged on the elastic membrane of the capsule cavity and close to the abutting part of the pressure head, and the rigid structure is made of a magnetic material.

7. The infusion system of claim 5, wherein:

the rigid structure comprises a first buckle part arranged on the elastic diaphragm of the capsule cavity and a second buckle part arranged in the pressure head, and the first buckle part is connected with the second buckle part in a buckling mode.

8. The infusion system of claim 5, wherein:

the pressure detection device comprises at least two pressure sensors, the first pressure sensor detects the pressure of the infusion liquid in the first capsule cavity and sends a first pressure detection signal to the driving controller, and the driving controller is further used for controlling the first driving device according to the first pressure detection signal and driving the first pressure head to move or stop moving;

the second pressure sensor detects the pressure of the infusion liquid in the second capsule cavity and sends a second pressure detection signal to the driving controller, and the driving controller is further used for controlling the second driving device according to the second pressure detection signal and driving the second pressure head to move or stop moving.

9. The infusion system of claim 8, wherein:

the infusion device further comprises a bubble sensor which detects the size or the accumulated bubble capacity of bubbles in the infusion liquid in the sac cavity and sends a first bubble signal or a second bubble signal to the driving controller, and the driving controller is further used for controlling the first driving device and/or the second driving device according to the first bubble signal and/or the second bubble signal and driving the first pressure head and/or the second pressure head to move or stop moving.

10. The infusion system of any one of claims 1 to 9, wherein:

the infusion device further comprises: an input device for setting infusion parameters; a display device for outputting display information; alarm means for outputting an alarm signal; and the power supply device is used for outputting electric energy for the infusion system.

11. An infusion method applied to an infusion system according to any one of claims 1 to 10, characterized in that the method comprises:

step S1, closing the first liquid inlet control valve, opening the first liquid outlet control valve, and closing the second liquid inlet control valve and the second liquid outlet control valve at the same time, driving the first pressure head to extend at a preset speed by the driving device, and extruding the elastic diaphragm of the first capsule cavity to deform to promote the reduction of the inner volume of the first capsule cavity, and discharging the infusion liquid through the liquid outlet until the first pressure head moves to the maximum position, at which time the inner volume of the first capsule cavity is minimum;

step S2, closing the second liquid inlet control valve, opening the second liquid outlet control valve, driving the second pressure head to extend at a preset speed by the driving device, extruding the elastic membrane of the second capsule cavity to deform to reduce the volume of the second capsule cavity, and discharging the infusion liquid through the liquid outlet until the second pressure head moves to the maximum position, wherein the volume of the second capsule cavity is minimum;

step S3, closing the first liquid inlet control valve and opening the first liquid outlet control valve, wherein the first pressure head continues to perform extension movement at a preset speed and extrudes the elastic membrane of the first capsule cavity to deform so as to promote the reduction of the internal volume of the first capsule cavity, and the infusion liquid is discharged through the liquid outlet of the first capsule cavity until the first pressure head moves to the maximum position, at which time the internal volume of the first capsule cavity is minimum;

step S4, repeating the step S2 and the step S3, so that the infusion system can perform infusion at a predetermined rate.

12. The method of claim 11, wherein:

after determining that the consumable structure is connected to the infusion device, step S0 is further performed, wherein step S0 includes controlling the first inlet control valve to close, the first outlet control valve to open, the second inlet control valve to open, and the second outlet control valve to close, so as to cause the first and second bladders to be filled with infusion liquid.

13. The method of claim 11, wherein:

in step S1, when the first ram extends to the maximum position, that is, when the volume in the first bladder cavity reaches the minimum, the first fluid inlet control valve is controlled to open, the first fluid outlet control valve is controlled to close, the second fluid inlet control valve is controlled to close, the second fluid outlet control valve is controlled to open, and the first ram is controlled to reset to urge the elastic diaphragm of the first bladder cavity to deform due to elastic recovery, so that negative pressure is generated in the first bladder cavity due to the elastic diaphragm deforming due to the elastic diaphragm recovery, and the infusion fluid is sucked into the first bladder cavity through the fluid inlet of the first bladder cavity.

14. The method of claim 13, wherein:

in step S2, when the second ram extends to the maximum position, that is, when the volume in the second bladder cavity reaches the minimum, the second fluid inlet control valve is controlled to open, the second fluid outlet control valve is controlled to close, the second ram is controlled to reset, negative pressure is generated in the second bladder cavity due to the elastic diaphragm of the second ram being deformed, and the infusion fluid is sucked into the second bladder cavity through the fluid inlet of the second bladder cavity.

15. The method according to claim 11 or 12, characterized in that:

in the above steps S1, S3, the pressure of the infusion liquid in the first capsule cavity is monitored in real time by the first pressure sensor of the pressure detection device, and a first pressure detection signal is sent to the driving controller, when the first pressure detection signal is greater than a preset pressure value, the driving controller controls the first driving device and the second driving device to stop driving, controls the first pressure head and the second pressure head to stop moving, and controls the alarm device to send out an alarm signal;

in the above step S2, the pressure of the infusion liquid in the second sac is monitored in real time by the second pressure sensor of the pressure detection device, and a second pressure detection signal is sent to the driving controller, when the second pressure detection signal is greater than the preset pressure value, the driving controller controls the first driving device and the second driving device to stop driving, controls the first pressure head and the second pressure head to stop moving, and controls the alarm device to send out an alarm signal.

16. The method according to claim 11 or 12, characterized in that:

the infusion device further comprises a bubble sensor that detects a bubble size or an accumulated bubble volume in the infusion liquid and sends a first bubble signal corresponding to the bubble size or a second bubble signal corresponding to the accumulated bubble volume to the drive controller;

the driving controller receives the first bubble signal or the second bubble signal, when the first bubble signal or the second bubble signal is larger than a preset bubble value set by the driving controller, the driving controller controls the first driving device and the second driving device to stop driving, controls the first pressure head and the second pressure head to stop moving, and controls the alarm device to send out an alarm signal.

17. The method according to claim 11 or 12, characterized in that: