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CN110787362B - Atmospheric-pressure aloe discharge plasma acne removal device and using method thereof - Google Patents

Atmospheric-pressure aloe discharge plasma acne removal device and using method thereof Download PDF

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Publication number
CN110787362B
CN110787362B CN201911136609.0A CN201911136609A CN110787362B CN 110787362 B CN110787362 B CN 110787362B CN 201911136609 A CN201911136609 A CN 201911136609A CN 110787362 B CN110787362 B CN 110787362B
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aloe
pressure
atmospheric
bottle body
quartz tube
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CN110787362A (en
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白成杰
李娜
姜守振
张超
杜军
潘杰
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Shandong Normal University
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Shandong Normal University
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • HELECTRICITY
    • H05ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
    • H05HPLASMA TECHNIQUE; PRODUCTION OF ACCELERATED ELECTRICALLY-CHARGED PARTICLES OR OF NEUTRONS; PRODUCTION OR ACCELERATION OF NEUTRAL MOLECULAR OR ATOMIC BEAMS
    • H05H1/00Generating plasma; Handling plasma
    • H05H1/24Generating plasma
    • H05H1/26Plasma torches
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M2037/0007Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin having means for enhancing the permeation of substances through the epidermis, e.g. using suction or depression, electric or magnetic fields, sound waves or chemical agents

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  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Plasma & Fusion (AREA)
  • Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Anesthesiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Medical Informatics (AREA)
  • Dermatology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Plasma Technology (AREA)

Abstract

The invention discloses an atmospheric pressure aloe discharge plasma acne removal device which comprises a first bottle body, a second bottle body, a vaporization mechanism, a premixing mechanism and an atmospheric pressure non-equilibrium plasma jet mechanism, wherein the first bottle body is used for containing inert gas, the second bottle body is used for containing a solvent containing aloe components, and the second bottle body is communicated with the vaporization mechanism; the first bottle body and the vaporization mechanism are communicated with the premixing mechanism, and the premixing mechanism is communicated with the atmospheric pressure non-equilibrium plasma jet mechanism. The invention uses the atmospheric pressure non-equilibrium plasma jet mechanism to jet out the solvent containing the aloe active ingredients in the form of plasma, and the solvent can permeate below the surface layer of the skin, thereby solving the effect which can not be achieved by smearing the medicine.

Description

Atmospheric-pressure aloe discharge plasma acne removal device and using method thereof
Technical Field
The invention relates to the field of medical equipment, in particular to an atmospheric pressure aloe discharge plasma acne removing device and a using method thereof.
Background
Aloe contains abundant nutrient substances, and its product is commonly used in fields of food, skin care, health promotion, medicine, etc., and has wide medical application. In aloe, the substances are mainly divided into two categories: anthraquinone compounds C14H8O2And a polysaccharide (C)6H10O5)nThe anthraquinone compounds can inhibit the oxidation and dehydrogenation of bacteria sugar and metabolic intermediate products, and can inhibit the synthesis of protein and nucleic acid, so that the toxic and side reactions and drug resistance of some clinical antibiotics can be avoided. In addition, the aloe is rich in a large amount of-COOH carboxyl chemical bond molecules, shows weak acidity, can disinfect, sterilize, remove acnes and nourish the face, and most of the aloe is directly used in a solid state or a liquid state.
The plasma contains reactive species such as electrons, ions, radicals, excited atoms, and molecules. The plasma temperature generated by the atmospheric pressure non-equilibrium plasma jet device is basically kept at normal temperature, and no electric damage is generated to human bodies. Because the atmospheric pressure non-equilibrium plasma jet flow has low temperature, good controllability and low energy consumption, the plasma can be generated in an open space, and the method has wide application prospect and important research significance in the aspects of biomedicine and the like.
Vaporization refers to the phase change process of a substance from a liquid state to a gas state, the liquid has small molecular distance, the gas has large molecular distance, and the liquid state can be changed into the gas state by a method of reducing pressure and raising temperature.
The inventor believes that because the stratum corneum of human skin is about 15 μm thick, when the medicine is applied on the skin surface, the active factors which play a role in the treatment cannot penetrate into the stratum corneum of the skin, and only on the skin surface, the skin can temporarily eliminate superficial bacteria and false acne, and the medicine cannot play a role in removing the acne from the root.
Disclosure of Invention
Aiming at the defects of the existing method for removing the acne by smearing the medicines and the curative effect, the invention aims to provide the atmospheric pressure aloe discharge plasma acne removing device and the using method thereof.
The first purpose of the invention is to provide an atmospheric pressure aloe discharge plasma acne removal device.
The second purpose of the invention is to provide a using method of the atmospheric pressure aloe discharge plasma acne removing device.
In order to realize the purpose, the invention discloses the following technical scheme:
in a first aspect, the invention discloses an atmospheric pressure aloe discharge plasma acne removal device, which comprises a first bottle body, a second bottle body, a vaporization mechanism, a premixing mechanism and an atmospheric pressure non-equilibrium plasma jet mechanism, wherein the first bottle body is used for containing inert gas, the second bottle body is used for containing a solvent containing aloe components, and the second bottle body is communicated with the vaporization mechanism; the first bottle body and the vaporization mechanism are communicated with the premixing mechanism, and the premixing mechanism is communicated with the atmospheric pressure non-equilibrium plasma jet mechanism.
Further, vaporization mechanism includes relief pressure valve and relief valve, the opening of first bottle with the opening of second bottle all connects the high-pressure chamber of relief pressure valve and connects the bottleneck, and the low-pressure chamber of relief pressure valve connects the gas outlet, and the relief valve is still connected to the relief valve.
Further, the premixing mechanism is a spiral pipeline mixer.
Further, a plurality of spiral mixing units are arranged in the pipe of the spiral pipeline mixer, and the spiral pipeline mixer is vertically arranged.
Further, the atmospheric pressure non-equilibrium plasma jet mechanism is driven by a radio frequency power supply, and radio frequency energy forms plasma in the quartz tube through pulse modulation and a radio frequency matcher.
Further, the radio frequency power supply frequency of the atmospheric pressure non-equilibrium plasma jet device is 13.56 MHz.
Further, the atmospheric pressure non-equilibrium plasma jet device comprises a quartz tube, a high-voltage electrode and an annular grounding electrode, wherein the high-voltage motor is positioned in the quartz tube, the annular grounding electrode is positioned at the end part of the quartz tube, the tube wall of the quartz tube is communicated with the premixing mechanism, and the annular grounding electrode and the high-voltage electrode are both connected with a radio frequency power supply.
Further, the quartz tube wall is provided with a cylindrical air inlet which is communicated with the premixing mechanism;
the high-voltage electrode is a needle electrode, the length of the high-voltage electrode is greater than that of the quartz tube, and the high-voltage electrode penetrates through the quartz tube in the axial direction;
and the annular grounding electrode is positioned at the position close to the pipe orifice on the cylindrical quartz tube.
Further, the outer diameter of the quartz tube is 1.8mm, the inner diameter is 1.6mm, and the length is 60 mm;
the high-voltage electrode is a needle electrode with the diameter of 1mm and the length of 75 mm;
the annular grounding electrode has an inner diameter of 1.8mm, an outer diameter of 1.9mm and a width of 5 mm.
Further, the inert gas is argon.
In a second aspect, the invention discloses a use method of an atmospheric pressure aloe discharge plasma acne removal device, which comprises the following steps:
filling inert gas into the first bottle body, and filling solvent containing aloe component into the second bottle body;
heating the second bottle and vaporizing the solvent containing the aloe component in the second bottle using a vaporizing device;
mixing the vaporized solvent containing aloe component with an inert gas using a premixing mechanism to obtain a mixed solvent;
the energized atmospheric pressure non-equilibrium plasma jet device emits the mixed solvent as a plasma.
Compared with the prior art, the invention has the following beneficial effects:
1) in the invention, the solvent containing the aloe active ingredient is ejected in the form of plasma by using an atmospheric pressure non-equilibrium plasma jet mechanism, and can permeate below the surface layer of the skin, thereby solving the effect which can not be achieved by smearing the medicine, and sending the aloe active ingredient into subcutaneous tissues to fully remove acnes.
2) In the invention, a low-temperature vaporizing device is used, the change of pressure is fully utilized to vaporize the solvent containing the aloe active ingredients, and the activity of the aloe in the vaporizing process is ensured; in addition, in the treatment process of the atmospheric pressure non-equilibrium plasma jet device, the vaporized aloe does not lose too much active substances due to low treatment temperature, and can ensure the efficacy of acting on removing acnes.
3) According to the invention, the spiral pipeline mixer is used for mixing the inert gas and the vaporized solvent containing the aloe active substance, so that the inert gas and the vaporized solvent containing the aloe active substance can be fully mixed, the mixed gas can be treated by the atmospheric pressure non-equilibrium plasma jet device, various gas components in the mixed gas can be excited into plasma, and the vaporized solvent containing the aloe active substance is carried into subcutaneous tissues.
Drawings
The accompanying drawings, which are incorporated in and constitute a part of this specification, are included to provide a further understanding of the invention, and are incorporated in and constitute a part of this specification, illustrate exemplary embodiments of the invention and together with the description serve to explain the invention and not to limit the invention.
Fig. 1 is a schematic structural diagram of embodiment 1.
In the figure, 1, a first bottle body, 2, a second bottle body, 3, a pressure reducing valve, 4, a gas inlet, 5, a spiral pipeline mixer, 6, a gas outlet of the spiral pipeline mixer, 7, a gas inlet of a quartz tube, 8, a high-voltage electrode, 9, an annular grounding electrode, 10, the quartz tube, 11, a radio-frequency power supply, 12, a pulse modulator, 13, a radio-frequency matcher, 14 and a gas flowmeter.
Detailed Description
It is to be understood that the following detailed description is exemplary and is intended to provide further explanation of the invention as claimed. Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs.
In the description of the present invention, it should be noted that the terms "upper", "lower", "left", "right", "vertical", "horizontal", "inner", "outer", etc., indicate orientations or positional relationships based on the orientations or positional relationships shown in the drawings, and are only for convenience of description and simplicity of description, but do not indicate or imply that the referred devices or elements must have specific orientations, be constructed in specific orientations, and be operated, and thus are not to be construed as limiting the present invention, and furthermore, the terms "first", "second", etc., are only used for descriptive purposes and are not to be construed as indicating or implying relative importance.
It is noted that the terminology used herein is for the purpose of describing particular embodiments only and is not intended to be limiting of exemplary embodiments according to the invention. As used herein, the singular forms "a", "an" and "the" are intended to include the plural forms as well, and it should be understood that when the terms "comprises" and/or "comprising" are used in this specification, they specify the presence of stated features, steps, operations, devices, components, and/or combinations thereof, unless the context clearly indicates otherwise.
As described in the background art, aiming at the defects of the existing method for removing acne by smearing medicines and the curative effect, the invention aims to provide an atmospheric pressure aloe discharge plasma acne removing device and a using method thereof.
Example 1
The embodiment discloses an atmospheric pressure aloe discharging plasma acne removing device which comprises a first bottle body 1, a second bottle body 2, a vaporizing mechanism, a premixing mechanism and an atmospheric pressure non-equilibrium plasma jet mechanism, wherein the first bottle body 1 is used for containing inert gas, the second bottle body 2 is used for containing a solvent containing aloe components, and the second bottle body 2 is communicated with the vaporizing mechanism; the first bottle body and the vaporization mechanism are communicated with the premixing mechanism, and the premixing mechanism is communicated with the atmospheric pressure non-equilibrium plasma jet mechanism.
The gas contained in the first bottle body 1 in this embodiment is argon gas, and helium gas or other inert gas can be used, and the inert gas can form plasma jet after being excited. In this embodiment, the second bottle body 2 contains pure non-oxidized aloe juice.
It can be understood that the device in this embodiment further includes a gas flow meter 14, the gas flow meter 14 is installed on the path from the first bottle 1 to the vaporizing mechanism and from the second bottle 2 to the premixing mechanism, the gas flow meter 14 is used for controlling the flow rates of the argon gas and the aloe gas, and the flow rates of both gases are 2.5L/min.
The vaporization mechanism comprises a pressure reducing valve 3 and a safety valve, the opening of the first bottle body 1 and the opening of the second bottle body 2 are both connected with a high-pressure cavity of the pressure reducing valve 3 to be connected with a bottle mouth, a low-pressure cavity of the pressure reducing valve 3 is connected with an air outlet, and the pressure reducing valve 3 is further connected with the safety valve.
The premixing mechanism is a spiral pipeline mixer 5.
The spiral pipeline mixer 5 is internally provided with a plurality of spiral mixing units, and the spiral pipeline mixer 5 is vertically arranged.
It will be appreciated that the helical pipe mixer 5 has a pipe diameter of 25mm and a length of 330mm and contains 6 to 8 helical mixing elements therein which are constantly cross-flowed to enable uniform mixing of the two gases. The pipeline mixer is vertically arranged, the argon inlet is a lower left port, and the aloe vaporized gas inlet is a lower right port.
The atmospheric pressure non-equilibrium plasma jet mechanism is driven by a radio frequency power supply 11, and radio frequency energy forms plasma in the quartz tube 10 through a pulse modulation and radio frequency matcher 13.
The frequency of a radio frequency power supply 11 of the atmospheric pressure non-equilibrium plasma jet device is 13.56MHz, the power is adjustable between 10W and 500W, the radio frequency power supply 11 is electrically connected with a pulse modulator 12 and a radio frequency matcher 13, the radio frequency is modulated by the pulse modulator 12, and discharge plasma is formed in the atmospheric pressure non-equilibrium plasma jet device through the radio frequency matcher 13.
The atmospheric pressure non-equilibrium plasma jet device comprises a quartz tube 10, a high-voltage electrode 8 and an annular grounding electrode 9, wherein the high-voltage motor is positioned in the quartz tube 10, the annular grounding electrode 9 is positioned at the end part of the quartz tube 10, the tube wall of the quartz tube 10 is communicated with a premixing mechanism, and the annular grounding electrode 9 and the high-voltage electrode 8 are both connected with a radio frequency power supply 11.
Further, the wall of the quartz tube 10 is provided with a cylindrical air inlet which is communicated with the premixing mechanism;
the high-voltage electrode 8 is a needle electrode, the length of the high-voltage electrode 8 is greater than that of the quartz tube 10, and the high-voltage electrode 8 penetrates through the quartz tube 10 in the axial direction;
the annular grounding electrode 9 is positioned close to the pipe orifice of the cylindrical quartz tube 10.
The quartz tube 10 has an outer diameter of 1.8mm, an inner diameter of 1.6mm and a length of 60 mm;
the high-voltage electrode 8 is a needle electrode with the diameter of 1mm and the length of 75 mm;
the annular grounding electrode 9 has an inner diameter of 1.8mm, an outer diameter of 1.9mm and a width of 5 mm.
The pipeline mixer mixes two gases according to a certain proportion, generally active gas and inert gas, and discharges in the plasma generating device to generate charged particles, excited particles, ultraviolet photons, free radicals and other ground state particles under the condition of not damaging active molecules. In order to prevent the problems that the molecules of the aloe are unstable and easy to collide after the vaporization, an inert gas is added into the aloe by using a pipeline mixer to make the aloe flow uniformly. The spiral structure in the tube can make argon and aloe gas (vaporized aloe gas) in a ratio of 1: 1 proportion is mixed into working gas, active particles in the plasma jet flow have longer service life and higher penetration depth, can penetrate through the horny layer of the skin to realize the acne removal of the root, and can realize better acne removal effect by combining aloe and the plasma.
It is understood that the atmospheric pressure non-equilibrium plasma jet mechanism used in the present embodiment belongs to the class of dielectric barrier discharge jet, and is characterized in that when the plasma jet does not contact any object, the discharge is like dielectric barrier discharge, however, once the plasma jet contacts the object to be treated, particularly, the ground conductor, the discharge is generated between the high voltage electrode 8 and the object to be treated. When the jet flow is used for plasma medicine, the treated object is actually a human body, and due to the danger of electric arc, the use of the jet flow device needs to be careful, and at present, a large number of clinical use cases exist, and the safety of the jet flow device can be guaranteed.
Example 2
Embodiment 2 discloses a method for using an atmospheric pressure aloe discharge plasma acne removal device, using the atmospheric pressure aloe discharge plasma acne removal device described in embodiment 1, comprising the following steps:
filling inert gas into the first bottle body, and filling solvent containing aloe component into the second bottle body;
heating the second bottle and vaporizing the solvent containing the aloe component in the second bottle using a vaporizing device;
mixing the vaporized solvent containing aloe component with an inert gas using a premixing mechanism to obtain a mixed solvent;
the energized atmospheric pressure non-equilibrium plasma jet device emits the mixed solvent as a plasma.
The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention, and various modifications and changes may be made by those skilled in the art. Any modification, equivalent replacement, or improvement made within the spirit and principle of the present invention should be included in the protection scope of the present invention.

Claims (8)

1. An atmospheric pressure aloe discharge plasma acne removal device is characterized by comprising a first bottle body, a second bottle body, a vaporization mechanism, a premixing mechanism and an atmospheric pressure non-equilibrium plasma jet mechanism, wherein the first bottle body is used for containing inert gas, the second bottle body is used for containing a solvent containing aloe components, and the second bottle body is communicated with the vaporization mechanism; the first bottle body and the vaporization mechanism are communicated with the premixing mechanism, and the premixing mechanism is communicated with the atmospheric pressure non-equilibrium plasma jet mechanism;
the premixing mechanism is a spiral pipeline mixer; the spiral pipeline mixer is internally provided with a plurality of spiral mixing units and is vertically arranged; 6-8 spiral mixing units are contained in the tube and continuously cross-flow, so that the two gases can be uniformly mixed;
the low-temperature vaporizing device is used, the change of pressure is fully utilized to vaporize the solvent containing the aloe active ingredients, and the activity of the aloe in the vaporizing process is ensured; in addition, the vaporized aloe does not lose excessive active substances in the treatment process of the atmospheric pressure non-equilibrium plasma jet device because of low treatment temperature.
2. The atmospheric-pressure aloe discharge plasma acne removal device according to claim 1, wherein the vaporization mechanism comprises a pressure reducing valve and a safety valve, the opening of the first bottle body and the opening of the second bottle body are both connected to a high-pressure chamber of the pressure reducing valve and connected to a bottle mouth, a low-pressure chamber of the pressure reducing valve is connected to an air outlet, and the pressure reducing valve is further connected to the safety valve.
3. The atmospheric-pressure aloe discharge plasma acne removal device according to claim 1, wherein the atmospheric-pressure non-equilibrium plasma jet mechanism is driven by a radio frequency power supply, and the radio frequency energy forms plasma in the quartz tube through pulse modulation and a radio frequency matcher.
4. The atmospheric-pressure aloe discharge plasma acne removal device of claim 1, wherein the radio frequency power frequency of the atmospheric-pressure non-equilibrium plasma jet device is 13.56 MHz.
5. The atmospheric-pressure aloe discharge plasma acne removal device according to claim 1, wherein the atmospheric-pressure non-equilibrium plasma jet device comprises a quartz tube, a high-voltage electrode and an annular grounding electrode, the high-voltage motor is located in the quartz tube, the annular grounding electrode is located at the end of the quartz tube, the wall of the quartz tube is communicated with the premixing mechanism, and the annular grounding electrode and the high-voltage electrode are both connected with a radio frequency power supply.
6. The atmospheric-pressure aloe discharge plasma acne removal device of claim 5,
the tube wall of the quartz tube is provided with a cylindrical air inlet which is communicated with the premixing mechanism;
the high-voltage electrode is a needle electrode, the length of the high-voltage electrode is greater than that of the quartz tube, and the high-voltage electrode penetrates through the quartz tube in the axial direction;
and the annular grounding electrode is positioned at the position close to the pipe orifice on the cylindrical quartz tube.
7. The atmospheric-pressure aloe discharge plasma acne removal device of claim 1, wherein the inert gas is argon.
8. Use of the atmospheric pressure aloe discharge plasma acne treatment device according to any of claims 1 to 7, characterized by comprising the following steps:
filling inert gas into the first bottle body, and filling solvent containing aloe component into the second bottle body;
heating the second bottle and vaporizing the solvent containing the aloe component in the second bottle using a vaporizing device;
mixing the vaporized solvent containing aloe component with an inert gas using a premixing mechanism to obtain a mixed solvent;
the energized atmospheric pressure non-equilibrium plasma jet device emits the mixed solvent as a plasma.
CN201911136609.0A 2019-11-19 2019-11-19 Atmospheric-pressure aloe discharge plasma acne removal device and using method thereof Expired - Fee Related CN110787362B (en)

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Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006001455A1 (en) * 2004-06-28 2006-01-05 The University Of Tokyo Plasma generator, in vivo plasma processing device using same, and surface processing device
CN104174049A (en) * 2007-11-06 2014-12-03 克里奥医药有限公司 Adjustable applicator assembly and plasma sterilization device
CN206181514U (en) * 2016-09-19 2017-05-17 李如粉 Low temperature plasma fluidic device
CN207070434U (en) * 2017-06-27 2018-03-02 中国科学院合肥物质科学研究院 Mixed gas plasma jet bactericidal unit
CN209120524U (en) * 2018-09-28 2019-07-16 山东师范大学 Atmospheric pressure low-power consumption room-temperature plasma fluidic device based on impulse modulation radio frequency

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006001455A1 (en) * 2004-06-28 2006-01-05 The University Of Tokyo Plasma generator, in vivo plasma processing device using same, and surface processing device
CN104174049A (en) * 2007-11-06 2014-12-03 克里奥医药有限公司 Adjustable applicator assembly and plasma sterilization device
CN206181514U (en) * 2016-09-19 2017-05-17 李如粉 Low temperature plasma fluidic device
CN207070434U (en) * 2017-06-27 2018-03-02 中国科学院合肥物质科学研究院 Mixed gas plasma jet bactericidal unit
CN209120524U (en) * 2018-09-28 2019-07-16 山东师范大学 Atmospheric pressure low-power consumption room-temperature plasma fluidic device based on impulse modulation radio frequency

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