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CN110681029A - Alzheimer disease prevention and treatment device and implementation method thereof - Google Patents

Alzheimer disease prevention and treatment device and implementation method thereof Download PDF

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Publication number
CN110681029A
CN110681029A CN201910936328.7A CN201910936328A CN110681029A CN 110681029 A CN110681029 A CN 110681029A CN 201910936328 A CN201910936328 A CN 201910936328A CN 110681029 A CN110681029 A CN 110681029A
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module
treatment
light
stimulation
microprocessor
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李桂香
陈军
黄德群
唐元梁
黄宁
谭仲威
徐飞
吴新社
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Guangdong Prov Medical Equipment & Instrument Research Inst
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Guangdong Prov Medical Equipment & Instrument Research Inst
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    • A61M21/00Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis
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Abstract

The invention discloses an Alzheimer disease prevention and treatment device and an implementation method thereof, wherein the method comprises the following steps: acquiring identity information of a patient; matching according to the identity information of the patient to obtain the working process of the device; emitting acousto-optic stimulation signals according to the matched device working process; receiving an ambient light variation frequency and an audio variation frequency; judging whether the abnormality occurs according to the ambient light change frequency and the audio change frequency, and if so, sending an audible and visual alarm signal; otherwise, executing the next step; patient information, treatment times and treatment times are stored and displayed. The device provided by the invention can realize prevention and treatment functions by matching the control signal of the microprocessor with the input signal of the key module and sending an acousto-optic cooperative signal through the acousto-optic stimulation and induction module.

Description

Alzheimer disease prevention and treatment device and implementation method thereof
Technical Field
The invention relates to the technical field of medical instruments, in particular to an Alzheimer disease prevention and treatment device and an implementation method thereof.
Background
Alzheimer disease is a nervous system degenerative disease with progressive development with hidden diseases, the pathological changes can affect multiple systems such as nerves, movement, urinary system and the like, cognitive function is reduced, behavior disorder, life ability is reduced and the like, and depression, anxiety, psychosis and the like are frequently complicated, so that patients gradually lose self-care ability, and families are greatly affected. At present, the examination mainly comprises neuropsychological test, hematology examination, neuroimaging examination, electroencephalogram, cerebrospinal fluid detection, gene detection and the like. The diagnosis is mainly carried out according to the signs of the symptoms of the patients, magnetic resonance display, abnormal cerebrospinal fluid biomarkers, clear gene mutation in relatives and the like. The core diagnostic criteria include: 1. early and significant episodic memory impairment; 2. atrophy of the medial temporal gyrus; 3. an abnormal cerebrospinal fluid biomarker, an elevated β amyloid 1-42(a β 1-42) concentration, an elevated total Tau protein concentration, or an elevated phosphorylated Tau protein concentration, or a combination of the three; specific imaging of PET functional nerve images, bilateral temporal and apical lobe glucose metabolic rate reduction; 5. there are clear AD-associated autosomal dominant mutations in the orthotopic relatives. The treatment policy is to control the accompanying psychopathological symptoms, improve the cognitive function and delay the disease progress.
At present, the treatment modes for senile dementia patients at home and abroad are drug treatment and behavioral correction. The treatment requires symptomatic treatment, with the aim of controlling the accompanying psychopathological symptoms, the use of anxiolytics, antidepressants, antipsychotics, nootropic or cognitive function-improving drugs: drugs acting on neurotransmitters, and drugs that activate brain metabolism. In addition to drug therapy, there is a need for scientific correction of the patient's behavior, i.e. non-drug therapy, mainly including mediterranean diet, exercise therapy, phototherapy, acupuncture therapy, music therapy, stress reduction, increased socialization, attention to sleep hygiene and training to receive knowledge of dementia.
Research and clinical findings show that although the drug therapy is used as a main treatment method, no radical drug exists, all drugs can only improve the cognitive condition of patients for a short time, the post-treatment of patients with severe dementia is relatively troublesome, and the curative effect of the drug is weakened or even ineffective. The treatment with antipsychotics is not helpful in improving cognitive function, but it can control the mental symptoms of the patient, such as anxiety, irritability, emotional instability, hallucinations, etc., which are troublesome to the care of the subjects and require the use of such drugs to control the mental symptoms. The non-drug therapy plays an important auxiliary role in treating the senile dementia, such as supporting the elderly to participate in social activities, work which can be achieved by more participation, or professional cognitive training and intelligence-promoting activities, and simultaneously needing auxiliary diet, nutrition and other exercises, and aiming at hopefully slowing down the cognitive decline.
The existing music therapy or light therapy has a certain relieving effect on senile dementia symptoms, but the property characteristics of music and light are not clearly used, the behavior of a patient is observed, the change analysis of specific indexes of the senile dementia patient is lacked, and a treatment mode and special equipment for simultaneous music therapy and phototherapy are not available.
Research finds that based on physiological indexes that Alzheimer's disease patients are closely related to the accumulation of beta amyloid and Tau protein in the brain, the frequency of gamma waves of a cerebral visual cortex (AC) is disturbed, and the like, through analyzing stimulus source characteristics of music and light treatment modes having curative effects on AD patients, the number of beta amyloid is reduced under 40Hz LED light treatment, 40Hz low-frequency sound has better effect and wider range than LED lamps only influencing the cerebral visual cortex under the same frequency, potentials of key areas CA1 and the like influencing the gamma waves in auditory cortex and hippocampus bodies show higher frequency, and the potential is better in cognitive function tests.
Therefore, it is an urgent problem to be solved how to directly eliminate the accumulation of β amyloid and Tau in the brain and correct the gamma wave frequency of the large cerebral visual cortex (AC) in alzheimer's disease patients, thereby physiologically treating and improving the cognitive function of the patients.
Disclosure of Invention
In view of this, the embodiments of the present invention provide an apparatus for preventing and treating alzheimer's disease with low cost, good effect and high stability, and an implementation method thereof.
In a first aspect, an embodiment of the present invention provides an alzheimer's disease prevention and treatment device, including a device body, where:
the key module is used for acquiring an input signal of a user;
the microprocessor module is used for triggering a control signal according to an input signal or a feedback signal and sending the control signal to the acoustic stimulation and induction module, the light stimulation and induction module and the display module;
the sound stimulation and induction module is used for carrying out sound stimulation according to the control signal of the microprocessor module, inducing sound change and providing a feedback signal for the microprocessor;
the light stimulation and induction module is used for performing light stimulation according to the control signal of the microprocessor module, inducing a light signal and providing a feedback signal for the microprocessor;
the power supply module is used for providing working power supply for the microprocessor module, the sound stimulation and induction module and the light stimulation and induction module;
the display module is used for displaying contents according to the control signal of the microprocessor, wherein the displayed contents include but are not limited to the treatment working time of the device and the treatment working times of the device;
the microprocessor module is respectively connected with the key module, the sound stimulation and induction module, the light stimulation and induction module, the power supply module and the display module.
Further, still be equipped with on the device body:
the storage module is used for storing the identity of the patient, the treatment course, the treatment times and the treatment time;
the alarm module is used for carrying out alarm prompt according to the control signal of the microprocessor module;
the storage module and the alarm module are both connected with the microprocessor module, and the power input end of the alarm module is connected with the power module.
Further, the alarm module includes:
the sound alarm module is used for carrying out sound alarm prompt according to the control signal of the microprocessor module;
the light alarm module is used for carrying out light alarm prompt according to the control signal of the microprocessor module;
and the sound alarm module and the light alarm module are both connected with the microprocessor module.
Further, the light stimulation and induction module comprises a light stimulation circuit and a light induction circuit.
Further, the acoustic stimulation and sensing module comprises an acoustic sensing circuit and an acoustic stimulation circuit.
In a second aspect, the present invention provides a method for implementing an alzheimer's disease prevention and treatment device, comprising the steps of:
acquiring identity information of a patient;
matching according to the identity information of the patient to obtain the working process of the device;
emitting acousto-optic stimulation signals according to the matched device working process;
receiving an ambient light variation frequency and an audio variation frequency;
judging whether the abnormality occurs according to the ambient light change frequency and the audio change frequency, and if so, sending an audible and visual alarm signal; otherwise, executing the next step;
patient information, treatment times and treatment times are stored and displayed.
Further, the method also comprises the following steps:
and after the treatment work flow is finished, if the power switch is not turned off, sending out voice prompt according to preset time.
Further, the step of obtaining the workflow of the device according to the patient identity information matching comprises the following steps:
analyzing the change in amyloid-beta content in the pathological brain of the patient by cerebrospinal fluid detection;
analyzing the amount of pathological plaque in the pathological brain by MRI images;
detecting the gamma wave frequency of the visual cortex of the brain of the patient and evaluating the cognitive function by electroencephalogram equipment to comprehensively obtain the treatment effect;
and matching to obtain a corresponding device working flow according to the treatment effect and by combining the medical record characteristics of the patient.
Further, the step of determining whether an abnormality occurs according to the ambient light variation frequency and the audio variation frequency includes the steps of:
analyzing the change frequency of background light in the environment, and judging whether the flicker frequency and the brightness of the light which emits light stimulation are qualified or not;
analyzing the audio detection result in the environment, and judging whether the volume and the frequency of the audio are qualified or not;
if the light flicker frequency, the light brightness, the audio volume and the audio frequency are all qualified, no abnormal condition exists; otherwise, an exception occurs.
One or more of the above-described embodiments of the present invention have the following advantages: the device provided by the invention realizes prevention and treatment functions by matching the control signal of the microprocessor with the input signal of the key module and sending an acousto-optic cooperative signal through the acousto-optic stimulation and induction module.
Drawings
FIG. 1 is a block diagram showing the overall structure of a low-frequency acousto-optic synergistic Alzheimer's disease prevention and treatment device according to the present invention;
FIG. 2 is a schematic structural diagram of a low-frequency acousto-optic synergistic Alzheimer's disease prevention and treatment device according to the present invention;
FIG. 3 is a schematic diagram of a photo-stimulation circuit of the present invention;
FIG. 4 is a schematic diagram of a light sensing circuit of the present invention;
FIG. 5 is a schematic diagram of the sound stimulation circuit of the present invention;
FIG. 6 is a schematic diagram of the sound sensing circuit of the present invention;
FIG. 7 is a flowchart illustrating steps according to an embodiment of the present invention.
Detailed Description
The invention will be further explained and explained with reference to the drawings and the embodiments in the description. The step numbers in the embodiments of the present invention are set for convenience of illustration only, the order between the steps is not limited at all, and the execution order of each step in the embodiments can be adaptively adjusted according to the understanding of those skilled in the art.
Referring to fig. 1, an embodiment of the present invention provides an alzheimer's disease prevention and treatment device, including a device body, on which:
the key module is used for acquiring an input signal of a user;
the microprocessor module is used for triggering a control signal according to an input signal or a feedback signal and sending the control signal to the acoustic stimulation and induction module, the light stimulation and induction module and the display module;
the sound stimulation and induction module is used for carrying out sound stimulation according to the control signal of the microprocessor module, inducing sound change and providing a feedback signal for the microprocessor;
the light stimulation and induction module is used for performing light stimulation according to the control signal of the microprocessor module, inducing a light signal and providing a feedback signal for the microprocessor;
the power supply module is used for providing working power supply for the microprocessor module, the sound stimulation and induction module and the light stimulation and induction module;
the display module is used for displaying contents according to the control signal of the microprocessor, wherein the displayed contents include but are not limited to the treatment working time of the device and the treatment working times of the device;
the microprocessor module is respectively connected with the key module, the sound stimulation and induction module, the light stimulation and induction module, the power supply module and the display module.
Further preferably, the apparatus body further includes:
the storage module is used for storing the identity of the patient, the treatment course, the treatment times and the treatment time;
the alarm module is used for carrying out alarm prompt according to the control signal of the microprocessor module;
the storage module and the alarm module are both connected with the microprocessor module, and the power input end of the alarm module is connected with the power module.
Further as a preferred embodiment, the alarm module comprises:
the sound alarm module is used for carrying out sound alarm prompt according to the control signal of the microprocessor module;
the light alarm module is used for carrying out light alarm prompt according to the control signal of the microprocessor module;
and the sound alarm module and the light alarm module are both connected with the microprocessor module.
Further preferably, the optical stimulation and sensing module includes an optical stimulation circuit and an optical sensing circuit.
Further preferably, the acoustic stimulation and sensing module includes an acoustic sensing circuit and an acoustic stimulation circuit.
The invention provides an implementation method of an Alzheimer disease prevention and treatment device, which comprises the following steps:
acquiring identity information of a patient;
matching according to the identity information of the patient to obtain the working process of the device;
emitting acousto-optic stimulation signals according to the matched device working process;
receiving an ambient light variation frequency and an audio variation frequency;
judging whether the abnormality occurs according to the ambient light change frequency and the audio change frequency, and if so, sending an audible and visual alarm signal; otherwise, executing the next step;
patient information, treatment times and treatment times are stored and displayed.
Further as a preferred embodiment, the method further comprises the following steps:
and after the treatment work flow is finished, if the power switch is not turned off, sending out voice prompt according to preset time.
Further preferably, the step of obtaining the workflow of the device according to the matching of the patient identity information includes the steps of:
analyzing the change in amyloid-beta content in the pathological brain of the patient by cerebrospinal fluid detection;
analyzing the amount of pathological plaque in the pathological brain by MRI images;
detecting the gamma wave frequency of the visual cortex of the brain of the patient and evaluating the cognitive function by electroencephalogram equipment to comprehensively obtain the treatment effect;
and matching to obtain a corresponding device working flow according to the treatment effect and by combining the medical record characteristics of the patient.
Further, as a preferred embodiment, the step of determining whether an anomaly occurs according to the ambient light variation frequency and the audio variation frequency includes the following steps:
analyzing the change frequency of background light in the environment, and judging whether the flicker frequency and the brightness of the light which emits light stimulation are qualified or not;
analyzing the audio detection result in the environment, and judging whether the volume and the frequency of the audio are qualified or not;
if the light flicker frequency, the light brightness, the audio volume and the audio frequency are all qualified, no abnormal condition exists; otherwise, an exception occurs.
The device and the implementation method thereof are described in detail in the following with the accompanying drawings of the specification:
referring to fig. 2, further as a preferred embodiment, the device body is provided with an arc-shaped handle 1.
Referring to fig. 2, as a further preferred embodiment, an LED light source window 3 is provided on the device body, an LED light source 2 is provided in the LED light source window 3, and an input end of the LED light source is connected to an output end of the microprocessor.
Referring to fig. 2, in a further preferred embodiment, the display module is a liquid crystal display, and the liquid crystal display 4 is disposed on a casing surface of the apparatus body.
Referring to fig. 2, as a further preferred embodiment, the key module includes a down key 5, an up key 13 and a review function key 6, and the down key 5, the up key 13 and the review function key 6 are all disposed below the liquid crystal display 4.
Referring to fig. 2, in a further preferred embodiment, a warning lamp 11 is arranged below the ring handle 1.
Referring to fig. 2, in a further preferred embodiment, a buzzer window 10 is provided at a position between the ring handle 1 and the warning lamp 11.
Referring to fig. 2, in a further preferred embodiment, an audio window 12 is provided on the apparatus body.
Referring to fig. 2, in a further preferred embodiment, a pedestal 16 is provided at the lower end of the device body, and a power indicator 7, a power switch 15, a USB power supply socket 8 and a power adapter socket 9 are provided on the pedestal 16; the storage module is a built-in SD card 17, and the built-in SD card 17 is arranged at the bottom of the pedestal.
In addition, as shown in fig. 2, the pedestal of the present embodiment is further provided with 0-3 numeral keys 14.
Referring to fig. 2, further as a preferred embodiment, the acousto-optic stimulation and sensing module is composed of a sound sensing circuit, a sound stimulation circuit, a light sensing circuit and a light stimulation circuit.
Specifically, the device provided by the invention has the advantages that the 40Hz low-frequency acousto-optic synergistic stimulation is regularly added to the senile dementia patient, so that the microglia which is the main component of the central nervous system of the brain is increased, the cell diameter is increased, the beta amyloid in the pathological brain of the AD patient is eliminated, the number of pathological plaques is reduced, and the treatment effect is judged by regularly detecting the content of the beta amyloid protein in the brain of the patient, the gamma wave frequency of the visual cortex (AC) of the brain and the cognitive function in the treatment process.
The device mainly comprises 6 parts of a microprocessor, an acousto-optic stimulation and induction module, a power supply module, a key and display module, a storage module and an acousto-optic alarm module, wherein a microprocessor circuit is used as a main control unit, and the device has the advantages of small volume, low cost, good stability, portability, convenience and the like.
The microprocessor module is an embedded system main control unit and is responsible for processing and calculating signals, prompting a patient to treat by timing voice, sending out a 40Hz low-frequency pulse signal, and controlling the on-off of the triode BD245-25 to control the operation of the acousto-optic stimulation module, thereby realizing the accurate control of acousto-optic frequency and working time and ensuring the periodicity and timeliness of treatment; and meanwhile, the signal of the acousto-optic induction module is collected, and the acousto-optic fault voice alarm circuit is controlled according to the signal. The microprocessor of the embodiment adopts an Atmega168 singlechip as the microprocessor, sends out voice prompts of treatment start and end at regular time, outputs a 40Hz PWM signal to control a triode Q2The LED1, the LED2 (shown in figure 3) and the voice chip GBG40 (shown in figure 5) of the LED lamp are switched on or off (shown in figure 3), so that acousto-optic cooperative stimulation is realized, meanwhile, an acousto-optic sensing signal is received to realize abnormal alarm control, and effective treatment is ensured; while also controlling the display and storage circuitry.
The acousto-optic stimulation and sensing module integrates acousto-optic synergetic generation and detection functions and mainly comprises an acousto-optic stimulation circuit consisting of an LED lamp, a voice chip, a microphone and a photosensitive diode and a sensing circuit for sound detection and light intensity detection. As shown in fig. 4, the present invention obtains the light sensing signal through D1, and then outputs the corresponding sensing signal to the microprocessor. As shown in FIG. 6, the present invention acquires the voice sensing signal through XF-18D, and outputs the Audio signal to the microprocessor after the signal is processed by the circuit. Under the control signal of 40Hz low-frequency pulse sent by the microprocessor, the acousto-optic cooperation of the LED lamp and the audio device is realized. Meanwhile, the sound detection circuit detects the intensity change of the sound and feeds the change back to the microprocessor, and the light detection circuit detects the background light change and feeds the change back to the microprocessor. The sound and light stimulation and induction module of the embodiment can be controlled by the MCU voice chip GBG40 to receive the language prompt sent by the main control chip and send 40Hz low frequency sound, and the XF-18D microphone detection sound detection module is adopted to realize the detection of the voice and feed back the detection result to the MCU; a low-energy 12V power supply is adopted to simultaneously supply a constant current source circuit and 2 white 20W LED lamps, a PWM signal sent by a main control chip is received to stably control the flicker and brightness of the white energy-saving lamp, and the change frequency of background light in the environment detected by a photosensitive diode is fed back to an MCU to judge whether the light flicker is normal or not.
The power supply module is a 5V rechargeable direct current power supply, is connected with a 220V and 50Hz to 5V power supply adapter through a round port during charging to directly supply power to the microprocessor module and the light stimulation and induction circuit, and supplies power to the sound stimulation and induction circuit after the voltage is reduced to 3V; the charger with 5V and 1A output can also be used for directly supplying power to the microprocessor module and the light stimulation and induction circuit through a USB (universal serial bus) port through a USB wire; in the power module of this embodiment, a 5V dc power converted from a 220V mains adapter supplies power to a control tube such as a microprocessor and a triode, an SX1318 chip is used in an internal booster circuit to raise the voltage to 12V to supply power to an LED1 and an LED2 (as shown in fig. 3) low-voltage energy-saving bulb, and the internal booster circuit converts the voltage to 3V dc voltage through an AMS1117-3.3 chip to supply power to a voice chip GBG40 (as shown in fig. 5).
The key and display module is provided with 4 keys, wherein the starting and the shutdown are one key, the stored data access playback function is one key, and the up/down selection is one key respectively; and a liquid crystal display interface (displaying treatment time and times); as shown in fig. 2, the key and display module of this embodiment is composed of 1 power switch key 15, 1 playback function key 6, 1 up-shift key 13 and down- shift key 5, 4 numeric keys 14, 1 LED lamp 7 and a liquid crystal display (LCD12864) 4. The power supply key 15 realizes the on-off of the power supply (short-press starting and long-press 1s shutting off); 1 playback function key fig. 5 for playback and viewing of treated patient information and times; 1 up-shift key 13 and down-shift key 5 for moving up and down information items; the LED lamp 7 is used to display the power-on state (red); 4 number keys of 0-3 are used for inputting the ID number of the patient, and the liquid crystal screen is used for displaying the ID number of the patient, the treatment time and the treated times in real time.
And the storage module is used for storing the treatment course, times (days) and each treatment time of the AD patient, and directly storing by adopting an SD card so as to be checked by doctors or family members of the AD patient and arrange to detect cerebrospinal fluid, MRI or cognitive function. The memory module of the present embodiment stores data by 1 16G custodon SD card 17. The microprocessor sends the patient information and the treatment times and time to be displayed in real time and simultaneously writes the patient information and the treatment times and time into the SD card to be stored for the family members of the patient or medical personnel to check the treatment times and time of the patient so as to arrange to carry out cognitive function detection and other evaluation modes to detect the treatment effect of the patient, and the collected data can be used for scientific research and analysis.
And the sound-light alarm module consists of an LED lamp, a buzzer and a control circuit and is used for giving an alarm by sensing abnormity in sound and light. The sound and light alarm module of the embodiment is composed of an LED lamp 11, 1 buzzer 10 and a control circuit thereof. The LED lamp 11 is used to reflect light sensing abnormality alarm (red flashing), and the buzzer 10 is used to reflect sound detection abnormality alarm.
Referring to fig. 7, the principle of the implementation method of the present invention is as follows: firstly, the power supply of the equipment is switched on, after a power key 15 is turned on, a power lamp 7 is turned on to be red, a microprocessor is initialized, and a patient is prompted to prepare for treatment, so that accompanying family members or medical staff can lose people or select patient information; then the microprocessor sends out 40Hz low-frequency PWM signals to control the acousto-optic stimulation and induction module to send out white light flicker and sound stimulation, and simultaneously receives the change frequency of the photosensitive diode to the ambient light and the change frequency of the audio frequency to compare with 40Hz, if the change frequency is abnormal, the acousto-optic alarm circuit 11 is started to reflect the light induction abnormal alarm (red flicker), the buzzer 10 rings and is shut down, and the acousto-optic synergy and the therapeutic effectiveness are ensured. During normal treatment, the microprocessor also stores the patient information, the treatment times and the time in the storage SD card 17 in real time and displays the patient information, the treatment times and the treatment time on the display screen 4; after normal treatment for 1 hour, the microprocessor sends out a treatment ending voice prompt, stores data in the SD card 17, ends treatment and enters a low-power consumption standby state, if a power switch is not turned off, the voice prompt treatment is carried out within a fixed time on the next day, and if the power switch is turned off, the power switch needs to be turned on to start the treatment process on the next day.
The low-frequency acousto-optic cooperative AD prevention and treatment stimulation device has the working process that: in a white wall dark sound space, under the condition that the low-frequency acousto-optic cooperative AD prevention and treatment stimulation device is powered by an adapter or a charger or a rechargeable battery, a power switch is turned on, a power lamp is in red, ID information of a patient to be treated is input or selected according to prompt of a display screen after voice prompt treatment, acousto-optic cooperative stimulation is started after confirmation, audio can emit 40Hz music, 20W white energy-saving lamps of 2 low-voltage LEDs flicker according to 40Hz PWM signals, if the device is normal, the duration lasts for 1 hour (if the acousto-optic cooperative treatment is abnormal, a buzzer sounds, a warning lamp flashes in red for 3 seconds, then the device is automatically turned off), and the display screen can display the treated times and the treated time in the process. When 1 hour is full, the device will send out a voice prompt for the end of treatment, and then the power can be turned off (if not, the device will enter a low power consumption timing mode, and prompt treatment at the same time in the next day, and if the same patient is treated 7 times continuously, the device will send out a voice prompt for examination or a new treatment cycle can be started.
In summary, the device of the present invention has the following advantages:
1. the invention utilizes the physiological characteristics that the accumulation of beta amyloid protein and Tau protein in the brain of the Alzheimer's disease patient is closely related to the disease of the senile dementia patient and the gamma wave frequency of the visual cortex (AC) of the brain of the AD patient can be disturbed, has certain effect on the treatment of the AD patient based on the music therapy and the light therapy, adopts the PWM signal of 40Hz to control the acousto-optic stimulation module, realizes the acousto-optic co-stimulation to the AD patient, through testing senile dementia mouse patients, cerebral spinal fluid, MRI images and electroencephalogram analysis are adopted to discover that microglia of main components of a central nervous system of a brain can be increased, the cell diameter can be increased, amyloid beta in pathological brains of AD mouse patients is reduced, the number of pathological plaques of temporal frontals in the MRI images is reduced, an electroencephalogram shows that the frequency of gamma waves of visual cortex (AC) of the brains is improved, and cognitive function detection also discovers that cognition of the AD mouse is improved. The device is portable and convenient, is suitable for carrying, provides a new treatment mode and special equipment for the old and difficult problem of treating AD patients at present, and breaks through the problems of the prior music therapy and light stimulation therapy that the property and the characteristics of music and light are not used clearly and the multiple invalidity of the equipment.
2. The low-frequency signal adopted in the invention is a PWM duty ratio adjustable signal of 40Hz, and the audio chip and the low-frequency LED white low-voltage energy-saving bulb are controlled to cooperatively generate acousto-optic stimulation through the output of an I/O port of a singlechip and the combination of a triode;
3. the low-frequency acousto-optic synergetic AD prevention and treatment stimulation device developed based on the technology mainly comprises 6 parts of a microprocessor, an acousto-optic stimulation and induction module, a power supply module, a key and display module, a storage module and an acousto-optic alarm module, and has the advantages of small size, low cost, good stability, portability, convenience in treatment and the like.
4. The sound and light stimulation and induction module can be a voice chip GBG40 chip controlled by the MCU, receives the language prompt sent by the main control MCU chip and sends out 40Hz low-frequency sound, adopts the micro microphone to detect the sound to realize the voice detection and feeds back the detection result to the MCU; the low-energy 12V power supply is adopted to simultaneously supply power to 2 white 20W LED energy-saving lamps, the two lamps receive PWM signal flicker sent by the main control chip, the intensity of background light in the environment is detected by utilizing a photosensitive diode, and the intensity change frequency is fed back to the MCU.
5. The low-frequency acousto-optic collaborative AD prevention and treatment stimulation device developed by the technology adopts a cylindrical base, and a circuit board is arranged inside the cylindrical base. A hollow circular ring arc-shaped table is placed on the upper portion of the base and is wedged with the ball on the upper portion, a clamping groove is formed in the front portion of the device, and a buckle is arranged on the outer portion of the rear portion of the device. Various LED lamps, buttons, display screens and the like are all fixed by glass glue to corresponding placing positions by leading out wires from an empty circular arc platform, the display screens are fixed with transparent covers outside by screw fixation four corners, LED white energy-saving lamps/loudspeakers are all arranged on the bottom plate, the four corners are fixed by screws, rectangular side windows are arranged outside, and an arc handle is arranged at the top of the device.
In alternative embodiments, the functions/acts noted in the block diagrams may occur out of the order noted in the operational illustrations. For example, two blocks shown in succession may, in fact, be executed substantially concurrently, or the blocks may sometimes be executed in the reverse order, depending upon the functionality/acts involved. Furthermore, the embodiments presented and described in the flow charts of the present invention are provided by way of example in order to provide a more thorough understanding of the technology. The disclosed methods are not limited to the operations and logic flows presented herein. Alternative embodiments are contemplated in which the order of various operations is changed and in which sub-operations, depicted as part of larger operations, are performed independently.
While the preferred embodiments of the present invention have been illustrated and described, it will be understood by those skilled in the art that various changes in form and details may be made therein without departing from the spirit and scope of the invention as defined in the appended claims.

Claims (9)

1. An alzheimer's disease prevention and treatment device, characterized in that: including the device body, be equipped with on the device body:
the key module is used for acquiring an input signal of a user;
the microprocessor module is used for triggering a control signal according to an input signal or a feedback signal and sending the control signal to the acoustic stimulation and induction module, the light stimulation and induction module and the display module;
the sound stimulation and induction module is used for carrying out sound stimulation according to the control signal of the microprocessor module, inducing sound change and providing a feedback signal for the microprocessor;
the light stimulation and induction module is used for performing light stimulation according to the control signal of the microprocessor module, inducing a light signal and providing a feedback signal for the microprocessor;
the power supply module is used for providing working power supply for the microprocessor module, the sound stimulation and induction module and the light stimulation and induction module;
the display module is used for displaying contents according to the control signal of the microprocessor, wherein the displayed contents include but are not limited to the treatment working time of the device and the treatment working times of the device;
the microprocessor module is respectively connected with the key module, the sound stimulation and induction module, the light stimulation and induction module, the power supply module and the display module.
2. The alzheimer's disease prevention and treatment device according to claim 1, wherein: still be equipped with on the device body:
the storage module is used for storing the identity of the patient, the treatment course, the treatment times and the treatment time;
the alarm module is used for carrying out alarm prompt according to the control signal of the microprocessor module;
the storage module and the alarm module are both connected with the microprocessor module, and the power input end of the alarm module is connected with the power supply module.
3. The alzheimer's disease prevention and treatment device according to claim 1, wherein: the alarm module includes:
the sound alarm module is used for carrying out sound alarm prompt according to the control signal of the microprocessor module;
the light alarm module is used for carrying out light alarm prompt according to the control signal of the microprocessor module;
and the sound alarm module and the light alarm module are both connected with the microprocessor module.
4. The alzheimer's disease prevention and treatment device according to claim 1, wherein: the light stimulation and induction module comprises a light stimulation circuit and a light induction circuit.
5. The alzheimer's disease prevention and treatment device according to claim 1, wherein: the acoustic stimulation and sensing module comprises an acoustic sensing circuit and an acoustic stimulation circuit.
6. The implementation method applying the device according to any one of claims 1-5, characterized in that: the method comprises the following steps:
acquiring identity information of a patient;
matching according to the identity information of the patient to obtain the working process of the device;
emitting acousto-optic stimulation signals according to the matched device working process;
receiving an ambient light variation frequency and an audio variation frequency;
judging whether the abnormality occurs according to the ambient light change frequency and the audio change frequency, and if so, sending an audible and visual alarm signal;
otherwise, executing the next step;
patient information, treatment times and treatment times are stored and displayed.
7. The method for implementing an alzheimer's disease prevention and treatment device according to claim 6, wherein: further comprising the steps of:
and after the treatment work flow is finished, if the power switch is not turned off, sending out voice prompt according to preset time.
8. The method for implementing an alzheimer's disease prevention and treatment device according to claim 6, wherein: the step of obtaining the workflow of the device according to the patient identity information matching comprises the following steps:
analyzing the change in amyloid-beta content in the pathological brain of the patient by cerebrospinal fluid detection;
analyzing the amount of pathological plaque in the pathological brain by MRI images;
detecting the gamma wave frequency of the visual cortex of the brain of the patient and evaluating the cognitive function by electroencephalogram equipment to comprehensively obtain the treatment effect;
and matching to obtain a corresponding device working flow according to the treatment effect and by combining the medical record characteristics of the patient.
9. The method for implementing an alzheimer's disease prevention and treatment device according to claim 6, wherein: the step of judging whether the abnormality occurs according to the ambient light change frequency and the audio change frequency includes the following steps:
analyzing the change frequency of background light in the environment, and judging whether the flicker frequency and the brightness of the light which emits light stimulation are qualified or not;
analyzing the audio detection result in the environment, and judging whether the volume and the frequency of the audio are qualified or not;
if the light flicker frequency, the light brightness, the audio volume and the audio frequency are all qualified, no abnormal condition exists; otherwise, an exception occurs.
CN201910936328.7A 2019-09-29 2019-09-29 Alzheimer disease prevention and treatment device and implementation method thereof Pending CN110681029A (en)

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CN111317904A (en) * 2020-03-14 2020-06-23 刘艳娟 A treatment device for treating alzheimer's disease
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