CN110613771A - Manufacturing process of eye patch for relieving dry eyes, unsmooth eyes and asthenopia - Google Patents
Manufacturing process of eye patch for relieving dry eyes, unsmooth eyes and asthenopia Download PDFInfo
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- CN110613771A CN110613771A CN201911070341.5A CN201911070341A CN110613771A CN 110613771 A CN110613771 A CN 110613771A CN 201911070341 A CN201911070341 A CN 201911070341A CN 110613771 A CN110613771 A CN 110613771A
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- dry eyes
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- 208000003556 Dry Eye Syndromes Diseases 0.000 title claims abstract description 34
- 206010013774 Dry eye Diseases 0.000 title claims abstract description 34
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- DTGKSKDOIYIVQL-WEDXCCLWSA-N (+)-borneol Chemical compound C1C[C@@]2(C)[C@@H](O)C[C@@H]1C2(C)C DTGKSKDOIYIVQL-WEDXCCLWSA-N 0.000 claims abstract description 14
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- 229940116229 borneol Drugs 0.000 claims abstract description 14
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- DTGKSKDOIYIVQL-UHFFFAOYSA-N dl-isoborneol Natural products C1CC2(C)C(O)CC1C2(C)C DTGKSKDOIYIVQL-UHFFFAOYSA-N 0.000 claims abstract description 14
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Classifications
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
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- A—HUMAN NECESSITIES
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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- A61K36/482—Cassia, e.g. golden shower tree
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
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- Health & Medical Sciences (AREA)
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- General Chemical & Material Sciences (AREA)
- Ophthalmology & Optometry (AREA)
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- Bioinformatics & Cheminformatics (AREA)
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Abstract
The invention provides a manufacturing process of an eye patch for relieving dry eyes, unsmooth eyes and asthenopia, which comprises the following steps: weighing saffron, medlar, achyranthes, tribulus terrestris, princesplume ladysthumb seed, cassia seed and chrysanthemum, and drying the medicines; step two, placing the dried medicine in the step one in a low-temperature storage device, breaking the wall at low temperature for 24 hours, taking out, and cooling to normal temperature; step three, putting the cooled medicine in the step two into distilled water, soaking for 0.5-2h, and heating to 100 ℃; taking out the medicines in the third step, putting the medicines into a pressure change storage device, and performing vacuum wall breaking extraction to obtain extract liquor; step five, taking out the extract liquid in the step four, and adding borneol for dissolving; taking out the liquid medicine, adding the laurocapram water molecule skin penetrating agent, adding the emulsifier, stirring, fully fusing the water and the oil, taking out after 2 hours, preparing the eye patch according to a proportion, and extracting the eye patch with fine molecules, which are more easily dissolved in the water and more fully absorbed.
Description
Technical Field
The invention relates to the technical field of medicinal patches, in particular to a manufacturing process of an eye patch for relieving dry eyes, unsmooth eyes and asthenopia.
Background
A research report of the world health organization shows that at present, shortsighted people in China reach 6 hundred million, and the shortsightedness rate of teenagers is the first in the world. The myopia rates of high school students and college students exceed seven percent and rise year by year, and the myopia rate of primary school students is close to 40 percent.
Myopia has become a civil disease in China and even has an influence on national strategic level. The main control methods at present are as follows: the optical refractive correction mainly adopts the wearing of glasses, is inconvenient, has strong dependence for two times and even deepens the condition. Secondly, the operation intervention is carried out, so that the effect of a small part of people is better, but the cost is high, and the operation intervention has certain risk. The medicine intervention is mostly dependent on western medicines, has certain side effects and is not obvious in effect; the traditional Chinese medicine for treating myopia has certain effects on dry eyes, unsmooth eyes and removal of blood filaments in the eyes, but the progress on relieving asthenopia is not great.
Disclosure of Invention
In order to solve the technical problems, the invention provides a manufacturing process of an eye patch for relieving dry eyes, dry eyes and asthenopia, which is characterized by comprising the following steps:
weighing saffron, medlar, achyranthes, tribulus terrestris, princesplume ladysthumb seed, cassia seed and chrysanthemum, and drying the medicines;
step two, placing the dried medicine in the step one in a low-temperature storage device, breaking the wall at a low temperature for 24 hours, taking out, and cooling to the normal temperature;
step three, putting the cooled medicine in the step two into distilled water, soaking for 0.5-2h, and heating to 100 ℃;
taking out the medicines in the third step, putting the medicines into a pressure change storage device, and performing vacuum wall breaking extraction to obtain extract liquor;
step five, taking out the extract liquid in the step four, and adding borneol for dissolving;
taking out the liquid medicine, adding the laurocapram water molecule skin penetrating agent, adding the emulsifier, stirring, fully fusing the water and the oil, taking out after 2 hours, and preparing the eye patch.
Further, the saffron, the medlar, the achyranthes bidentata, the caltrop, the prince ladysthumb fruit, the cassia seed and the chrysanthemum are weighed according to the weight ratio of 1:1:1:1:1: 1.
Further, the temperature of the low-temperature storage in the second step is any one of-60 ℃, 80 ℃ or-100 ℃.
Further, the temperature of the low-temperature storage in the second step is-80 ℃.
Further, the pressure of the pressure change storage in the third step is 4-11 MPa.
Further, the vacuum degree of vacuum wall breaking in the third step is 0.08-0.15 MPa.
Further, the weight ratio of the extract liquid in the fifth step to the borneol is 5: 1-8: 1.
Furthermore, the liquid medicine in the sixth step is laurocapram water molecule and emulsifier which are 6:1:1 to 9:1: 1.
The invention has the following beneficial effects:
1. compared with the traditional Chinese medicine obtained by only carrying out low-temperature wall breaking or vacuum wall breaking technology on the current market, the traditional Chinese medicine has better effects of relieving asthenopia, dry eyes and unsmooth eyes;
2. the extracted molecules are fine and are more easily dissolved in water, so that the absorption is more sufficient;
3. the water molecule skin penetrating agent and the emulsifier are matched to ensure that the medicine components directly penetrate subcutaneous tissues and the medicine effect is better played.
Drawings
Fig. 1 is a process flow chart for manufacturing an eye patch for relieving dry eyes, dry eyes and asthenopia.
Detailed Description
In order to make the aforementioned objects, features and advantages of the present invention comprehensible, embodiments accompanied with figures are described in detail below. In the following description, numerous specific details are set forth in order to provide a thorough understanding of the present invention. This invention may, however, be embodied in many different forms and should not be construed as limited to the embodiments set forth herein, but rather should be construed as broadly as the present invention is capable of modification in various respects, all without departing from the spirit and scope of the present invention.
Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. The terminology used in the description of the invention herein is for the purpose of describing particular embodiments only and is not intended to be limiting of the invention.
The invention discloses a manufacturing process of an eye patch for relieving dry eyes, unsmooth eyes and asthenopia, which comprises the following steps:
weighing saffron, medlar, achyranthes, tribulus terrestris, princesplume ladysthumb seed, cassia seed and chrysanthemum, and drying the medicines;
step two, placing the dried medicine in the step one in a low-temperature storage device, breaking the wall at a low temperature for 24 hours, taking out, and cooling to the normal temperature;
step three, putting the cooled medicine in the step two into distilled water, soaking for 0.5-2h, and heating to 100 ℃;
taking out the medicines in the third step, putting the medicines into a pressure change storage device, and performing vacuum wall breaking extraction to obtain extract liquor;
step five, taking out the extract liquid in the step four, and adding borneol for dissolving;
taking out the liquid medicine, adding the laurocapram water molecule skin penetrating agent, adding the emulsifier, stirring, fully fusing the water and the oil, taking out after 2 hours, and preparing the eye patch.
In the second step of the invention, the temperature of the low-temperature storage is any one of-60 ℃, 80 ℃ or-100 ℃.
The pressure of the pressure change storage in the third step of the invention is 4-11 MPa.
The vacuum degree of vacuum wall breaking in the third step of the invention is 0.08-0.15 MPa.
The weight ratio of the extract liquid to the borneol in the step five of the invention is 5: 1-8: 1.
The invention comprises six steps of traditional Chinese medicine liquid, namely laurocapram water molecule and emulsifier, wherein the emulsifier is 6:1: 1-9: 1:1
The medicine of the invention has the following properties:
saffron crocus (nature and taste) is sweet and neutral. [ FUNCTIONS ] can promote blood circulation, remove blood stasis, dispel stagnation, and resolve stagnation. For melancholia, chest stuffiness and oppression, hematemesis, typhoid fever, mania, trance, amenorrhea, postpartum abdominal pain due to blood stasis, and traumatic injury.
Medlar (nature and taste) is sweet and neutral. [ FUNCTIONS ] can nourish kidney, moisten lung, tonify liver, and improve eyesight. It is indicated for liver and kidney yin deficiency, soreness and weakness of waist and knees, dizziness, blurred vision, hyperdacryosis, cough due to asthenia, diabetes, and spermatorrhea.
Achyranthes bidentata (sexual and taste) is bitter, sour and neutral. [ FUNCTIONS ] can tonify liver and kidney, strengthen tendons and bones, remove blood stasis, dredge channels, and draw blood downward. Can be used for treating soreness of waist and knees, weakness of tendons and bones, amenorrhea, abdominal mass, and vertigo due to liver-yang.
Tribulus terrestris (nature and taste) is pungent, bitter and slightly warm; has little toxicity. [ FUNCTIONS ] can calm the liver, relieve depression, promote blood circulation, dispel wind, improve eyesight, and relieve itching. Can be used for treating headache, vertigo, distending pain in chest and hypochondrium, milk retention, mammary abscess, conjunctival congestion, nebula, rubella and pruritus.
Fructus Polygoni orientalis (nature and taste) is salty and cold. [ FUNCTIONS ] can remove blood stasis, remove food stagnation, invigorate spleen, and promote diuresis. It is indicated for hypochondriac and abdominal mass, tympanites, stomachache, anorexia, abdominal distention, eye fire, sore and swelling, scrofula.
Semen Cassiae (sexual taste) is bitter and sweet, and is cool. [ FUNCTIONS ] can clear liver, improve vision, promote diuresis, and relieve constipation. It can be used for treating wind-heat type acute contagious conjunctivitis, cyanosis, bromhidrosis, hypertension, hepatitis, ascites due to liver cirrhosis, and habitual constipation.
Chrysanthemum flower (nature and taste) is sweet, bitter and cool. [ FUNCTIONS ] can dispel pathogenic wind, clear away heat, improve eyesight, and remove toxic substance. It can be used for treating headache, vertigo, conjunctival congestion, dysphoria with smothery sensation in chest, furuncle, and toxic swelling.
Borneol (temperament and flavour) is bitter and cool. [ FUNCTIONS ] can dredge orifices, dispel stagnated fire, remove nebula, improve eyesight, and relieve swelling and pain. It is indicated for wind stroke, vomiting, coma due to febrile disease, epilepsy due to convulsion, phlegm-phlegm, qi block, deafness, sore throat, aphtha, otitis media, carbuncle, swelling, hemorrhoid, nebula, and enterobiasis.
Example 1
The embodiment discloses a manufacturing process of an eye patch for relieving dry eyes, dry eyes and asthenopia, which comprises the following steps:
weighing saffron crocus, medlar, achyranthes, caltrop, fructus polygoni orientalis, cassia seed and chrysanthemum according to the weight ratio of 1:1:1:1:1, and drying the medicines;
step two, placing the dried medicine in the step one in a low-temperature storage device at the temperature of minus 80 ℃, breaking the wall at the low temperature for 24 hours, taking out the medicine, and cooling the medicine to the normal temperature;
step three, putting the cooled medicine in the step two into distilled water, soaking for 0.5-2h, and heating to 100 ℃;
step four, taking out the medicines in the step three, putting the medicines into a pressure change storage device, and performing vacuum wall breaking extraction to obtain extract liquor, wherein the pressure is 4-11MPa, and the vacuum degree is 0.08 MPa;
taking out the extract liquid in the step four, adding borneol for dissolving, wherein the weight ratio of the extract liquid to the borneol is 5: 1;
taking out the liquid medicine, adding the laurocapram water molecule skin penetrating agent, adding the emulsifier, stirring, fully fusing the water and the oil, taking out after 2 hours, and preparing the eye patch according to the ratio of the liquid medicine, the laurocapram water molecule and the emulsifier being 6:1: 1.
Example 2
The embodiment discloses a manufacturing process of an eye patch for relieving dry eyes, dry eyes and asthenopia, which comprises the following steps:
weighing saffron crocus, medlar, achyranthes, caltrop, fructus polygoni orientalis, cassia seed and chrysanthemum according to the weight ratio of 1:1:1:1:1, and drying the medicines;
step two, placing the dried medicine in the step one in a low-temperature storage device at the temperature of minus 80 ℃, breaking the wall at the low temperature for 24 hours, taking out the medicine, and cooling the medicine to the normal temperature;
step three, putting the cooled medicine in the step two into distilled water, soaking for 0.5-2h, and heating to 100 ℃;
step four, taking out the medicines in the step three, putting the medicines into a pressure change storage device, and performing vacuum wall breaking extraction to obtain an extract, wherein the pressure is 4-11MPa, and the vacuum degree is 0.15 MPa;
step five, taking out the extract liquid in the step four, adding borneol for dissolving, wherein the weight ratio of the extract liquid to the borneol is 8: 1;
taking out the liquid medicine, adding the laurocapram water molecule skin penetrating agent, adding the emulsifier, stirring, fully fusing the water and the oil, taking out after 2 hours, and preparing the eye patch according to the ratio of the liquid medicine, the laurocapram water molecule and the emulsifier being 9:1: 1.
Example 3
The embodiment discloses a manufacturing process of an eye patch for relieving dry eyes, dry eyes and asthenopia, which comprises the following steps:
weighing saffron crocus, medlar, achyranthes, caltrop, fructus polygoni orientalis, cassia seed and chrysanthemum according to the weight ratio of 1:1:1:1:1, and drying the medicines;
step two, placing the dried medicine in the step one in a low-temperature storage device at the temperature of minus 80 ℃, breaking the wall at the low temperature for 24 hours, taking out the medicine, and cooling the medicine to the normal temperature;
step three, putting the cooled medicine in the step two into distilled water, soaking for 0.5-2h, and heating to 100 ℃;
step four, taking out the medicines in the step three, putting the medicines into a pressure change storage device, and performing vacuum wall breaking extraction to obtain an extract, wherein the pressure is 4-11MPa, and the vacuum degree is 0.12 MPa;
step five, taking out the extract liquid in the step four, adding borneol for dissolving, wherein the weight ratio of the extract liquid to the borneol is 6: 1;
taking out the liquid medicine, adding a laurocapram water molecule skin penetrating agent, adding an emulsifier, stirring, fully fusing water and oil, taking out after 2 hours, and mixing the liquid medicine, laurocapram water molecule and emulsifier, wherein the weight ratio of the liquid medicine to the emulsifier is 8: 1:1 dispensing the eye patch.
This embodiment is the most preferred embodiment.
Comparative example 1
The difference from example 3 is that this comparative example does not employ a vacuum wall breaking technique.
Comparative example 2
The difference from example 3 is that this comparative example does not employ a low temperature wall breaking technique.
The clinical treatment cases are as follows:
yan for 12-year-old girl, dry eye, astringent eye, and asthenopia, the vision before treatment is 0.15, the total treatment times is 32 times after two weeks of treatment, wherein the treatment times is 19 times when reaching 1.0, the vision after treatment is 1.5, the eye symptoms disappear in three months, and no rebound occurs in the fourth month.
The clinical treatment results of the patients with dry eyes, dry eyes and asthenopia treated by the eye patch prepared in example 3 are listed below for 40 patients.
See Table 1
TABLE 1
Wherein, the vision values before and after treatment are recorded according to a standard logarithmic hyperopia chart (5 meters) by decimal numbers.
In the embodiments 1 to 3 of the present invention, 100 patients with dry eyes, dry eyes and asthenopia were treated, and the treatment effects are shown in table 2.
TABLE 2
Wherein, the specific effect means that the treatment effect reaches the vision of 1.0 and above;
the effective means that the vision value after treatment is larger than the vision value before treatment.
Comparative examples 1 to 2 were compared with the effect of example 3, which is the most effective in the present application.
See Table 3
| Parameter(s) | Comparative example 1 | Comparative example 2 | Example 3 |
| Residual (%) | 25％ | 20％ | Is free of |
| Fineness (mesh) | 410 | 400 | 500 |
TABLE 3
The monarch drug is cassia seed, the ministerial drug is saffron, medlar (enhancing immunity), tribulus terrestris, chrysanthemum, the adjuvant drug, achyranthes root and fructus polygoni orientalis, and the conductant drug is achyranthes root, through the compatibility of the monarch, ministerial, assistant and guide and by adopting the combination of the low-temperature wall breaking technology and the vacuum wall breaking technology, a better wall breaking effect can be obtained, as can be seen in table 3, no residue exists in example 3, part of residue exists in comparative example 1 and comparative example 2, the wall breaking effect of example 3 is obviously superior to that of comparative example 1 and comparative example 2, the fineness of example 3 can reach 500 meshes and above and is far higher than that of comparative example 1 and comparative example 2, so that the extraction molecules of example 3 are fine, are more easily dissolved in water, and are; the water molecule skin penetrating agent and the emulsifier are matched to ensure that the medicine components directly penetrate subcutaneous tissues and the medicine effect is better played.
The technical features of the embodiments described above may be arbitrarily combined, and for the sake of brevity, all possible combinations of the technical features in the embodiments described above are not described, but should be considered as being within the scope of the present specification as long as there is no contradiction between the combinations of the technical features.
The above-mentioned embodiments only express several embodiments of the present invention, and the description thereof is more specific and detailed, but not construed as limiting the scope of the invention. It should be noted that, for a person skilled in the art, several variations and modifications can be made without departing from the inventive concept, which falls within the scope of the present invention. Therefore, the protection scope of the present patent shall be subject to the appended claims.
Claims (8)
1. A manufacturing process of an eye patch for relieving dry eyes, unsmooth eyes and asthenopia is characterized by comprising the following steps:
weighing saffron, medlar, achyranthes, tribulus terrestris, princesplume ladysthumb seed, cassia seed and chrysanthemum, and drying the medicines;
step two, placing the dried medicine in the step one in a low-temperature storage device, breaking the wall at a low temperature for 24 hours, taking out, and cooling to the normal temperature;
step three, putting the cooled medicine in the step two into distilled water, soaking for 0.5-2h, and heating to 100 ℃;
taking out the medicines in the third step, putting the medicines into a pressure change storage device, and performing vacuum wall breaking extraction to obtain extract liquor;
step five, taking out the extract liquid in the step four, and adding borneol for dissolving;
taking out the liquid medicine, adding the laurocapram water molecule skin penetrating agent, adding the emulsifier, stirring to fully fuse the water and the oil, taking out after 2 hours, and preparing the eye patch.
2. The manufacturing process of the eye patch for relieving dry eyes, unsmooth eyes and asthenopia according to claim 1, wherein the saffron crocus, the medlar, the achyranthes bidentata, the caltrop, the princesplume ladysthumb fruit, the cassia seed and the chrysanthemum are weighed according to the weight ratio of 1:1:1:1:1: 1.
3. The manufacturing process of the eye patch for relieving dry eyes, dry eyes and asthenopia according to claim 1, wherein the temperature of the low temperature storage in the second step is any one of-60 ℃, 80 ℃ or-100 ℃.
4. The manufacturing process of the eye patch for relieving dry eyes, dry eyes and asthenopia according to claim 3, wherein the temperature of the low-temperature storage in the second step is-80 ℃.
5. The process for preparing an eye patch for relieving dry eyes, unsmooth eyes and asthenopia according to claim 1, wherein the pressure of the pressure change reservoir in the third step is 4-11 MPa.
6. The manufacturing process of the eye patch for relieving dry eyes, dry eyes and asthenopia according to claim 1, wherein the vacuum degree of vacuum wall breaking in the third step is 0.08-0.15 MPa.
7. The manufacturing process of the eye patch for relieving dry eyes, dry eyes and asthenopia according to claim 1, wherein the weight ratio of the extract liquid obtained in the step five to the borneol is 5: 1-8: 1.
8. The manufacturing process of the eye patch for relieving dry eyes, unsmooth eyes and asthenopia according to claim 1, wherein the water molecules of laurocapram and the emulsifier are 6:1: 1-9: 1: 1.
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| CN111759916A (en) * | 2020-07-29 | 2020-10-13 | 深圳职业技术学院 | Manufacturing process of eye patch for relieving dry eyes, unsmooth eyes and asthenopia |
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Application publication date: 20191227 |