CN110354304A - Substrate and its preparation process for prosthese after artificial joint replacement - Google Patents
Substrate and its preparation process for prosthese after artificial joint replacement Download PDFInfo
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- CN110354304A CN110354304A CN201910689296.5A CN201910689296A CN110354304A CN 110354304 A CN110354304 A CN 110354304A CN 201910689296 A CN201910689296 A CN 201910689296A CN 110354304 A CN110354304 A CN 110354304A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/02—Inorganic materials
- A61L27/04—Metals or alloys
- A61L27/06—Titanium or titanium alloys
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/28—Materials for coating prostheses
- A61L27/30—Inorganic materials
- A61L27/306—Other specific inorganic materials not covered by A61L27/303 - A61L27/32
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/28—Materials for coating prostheses
- A61L27/34—Macromolecular materials
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/54—Biologically active materials, e.g. therapeutic substances
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- C—CHEMISTRY; METALLURGY
- C25—ELECTROLYTIC OR ELECTROPHORETIC PROCESSES; APPARATUS THEREFOR
- C25D—PROCESSES FOR THE ELECTROLYTIC OR ELECTROPHORETIC PRODUCTION OF COATINGS; ELECTROFORMING; APPARATUS THEREFOR
- C25D11/00—Electrolytic coating by surface reaction, i.e. forming conversion layers
- C25D11/02—Anodisation
- C25D11/26—Anodisation of refractory metals or alloys based thereon
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/204—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials with nitrogen-containing functional groups, e.g. aminoxides, nitriles, guanidines
- A61L2300/206—Biguanides, e.g. chlorohexidine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
- A61L2300/606—Coatings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2420/00—Materials or methods for coatings medical devices
- A61L2420/02—Methods for coating medical devices
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2420/00—Materials or methods for coatings medical devices
- A61L2420/08—Coatings comprising two or more layers
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Abstract
The invention belongs to medical material fields, it is related to a kind of implanting artificial limb material, specifically the substrate and its preparation process for prosthese after artificial joint replacement, a kind of substrate for prosthese after artificial joint replacement, including Titanium base, it is overlying on the TiO of titanium-based external surface2Nanotube coating and be coated on the TiO2Antibiotic layer on nanotube coating, the antibiotic layer are coated using PHMG solution.Novel environment-friendly antibacterial agent PHMG is carried on TiO by the present invention2Nanotube, can be simultaneously using PHMG as the superiority of antibacterial agent and TiO2Superiority of the nanotube as load, to provide new direction for Periprosthetic infection after the prevention artificial joint replacement in terms of artificial prosthesis material.And pass through the improvement to preparation process, on Titanium base, TiO2The rounded structure of nanotube, size is more uniform, and arrangement is more regular, and caliber is suitable, is suitable as the carrier material of PHMG, and the nanotube coatings on surface are secured, will not fall off.
Description
Technical field
The invention belongs to medical material fields, are related to a kind of implanting artificial limb material, specifically set for joint prosthesis
Change the substrate and its preparation process of postoperative prosthese.
Background technique
As society is constantly progressive, the average life span is constantly promoted, and aging trend is gradually presented in society, following
It is that the patient populations for needing to receive artificial joint replacement due to bone joint degeneration in recent years all increase.It is protected according to U.S. sanitary
The prediction of strong consultative committee, from 2006 to 2016 year, the annual hip in the U.S., knee prosthesis quantity will increase to from 910,000
1300000, and calculated according to Kurz, to the year two thousand thirty, artificial knee joint replacement for the first time with overhaul quantity and will increase by 673%, 601% respectively,
Artificial hip joint replacing for the first time with overhaul quantity will respectively increase by 174%, 137%.
Postoperative Periprosthetic infection is the catastrophic complication of prosthetic replacement, and Periprosthetic sense once occurs in patient
Dye, then treatment course significantly extends, it is likely that needs to receive the operation above at least twice, and the limbs of quite a few patient
Functional rehabilitation is undesirable, more has small number of patients to have to receive the joint fusion even painful result of amputation.Due to the length for the treatment of
Phase property and difficulty, Periprosthetic, which is infected, brings huge challenge and pressure to doctor and patient and medical institutions.It is false in the U.S.
Oneself is infected around body after as the most common reason and artificial total hip arthroplasty is overhauled after total knee arthroplasty
The third-largest reason is overhauled, because of Periprosthetic infector, medical expense highest (is removed
External cause Periprosthetic fracture and receive the patient overhauled).Periprosthetic infection rate is about after artificial joint replacement
2.0-2.4%, separately there is author's proposition, postoperative Periprosthetic infection actually occurs rate than sense that joint prosthesis registration center registers
The high 33%-40% of dye rate.In the U.S., the medical expense of every artificial hip joint infection and artificial knee joint infection is respectively 25692
Dollar with 31753 dollars, it is contemplated that arrive the year two thousand twenty or so, it is annual for treating the flower of Periprosthetic infection after artificial joint replacement
Take up to 16.2 hundred million dollars.
For postoperative Periprosthetic when infecting, prosthetic surface will appear bacterial adhesion, field planting, and form biomembrane knot
Structure, biomembrane can help the attack of the immunologic mechanism and antibacterial agent of bacterium escape host, and the serious drug resistance of bacterium in biomembrane,
Chronic infection is caused not recover for a long time.Titanium or titanium alloy has become the most common artificial joint prosthesis material of orthopaedics at present, wherein one
A critically important reason is exactly that titanium or titanium alloy prosthese biocompatibility is good, and this characteristic generally has benefited from vacation under physiological status
The formation of body surface face albumin layer, however these albumen but make prosthetic surface be more suitable adherency, field planting and the biology of bacterium
The formation of film.It is existing clinic antibacterials to biomembrane almost without lethal effect, so finding one kind effectively reduces prosthese table
Face bacterial adhesion, field planting are to prevent the artificial joint prosthesis material of biofilm formation from becoming joint surgery doctor and materialogy research
One of primary study content of personnel.And antibacterial surface processing is carried out to artificial joint prosthesis material, postoperative prosthese can be reduced
The adherency and field planting of surface bacteria are the focus on research direction of prevention of postoperative Periprosthetic infection in recent years.
Antibacterial agent is loaded into the porous hydroxylapatite coating of titanium prosthetic surface by the past researcher by special process
On, In vivo study prove its can pre- aseptic generation to a certain extent, however the condition of high temperature during the preparation process makes
Antibacterial agent is not directly added among material, so that the load capacity on its surface is very few, and is had during antibacterial agent release
Explosive release characteristics, these problems limit it and are widely used.In addition, Antoci V etc. is successfully by titanium alloy surface and ten thousand
Ancient mycin covalent bond, it is contemplated that realize long-acting antibacterial ability, find that Staphylococcus aureus can be effectively suppressed in it in experiment in vitro
Adherency, the aggregation of bacterium and staphylococcus epidermis also have antibacterial efficacy to the multiple infection of bacterium, can inhibit the shape of biomembrane
At.
But the titanium prosthesis of covalent bond vancomycin will form a protein layer and be deposited on vacation after implanting
Body surface face, it is still unknown to generate antibacterial efficacy that can covalently bound vancomycin penetrate this protein layer.
Summary of the invention
In order to overcome drawbacks described above existing for prosthese after existing artificial joint replacement, the present invention provides a kind of for artificial
The substrate of the postoperative prosthese of joint replacement, by novel environment-friendly antibacterial agent polyhexamethylene guanide (polyhexamethylene
Guanidine, PHMG) it is carried on TiO2 nanotube, it can be simultaneously using PHMG as the superiority of antibacterial agent and TiO2 nanometers
Superiority of the pipe as load, to be infected for Periprosthetic after the prevention artificial joint replacement in terms of artificial prosthesis material
New direction is provided.
The present invention adopts the following technical scheme that:
A kind of substrate for prosthese after artificial joint replacement, including Titanium base are overlying on the TiO2 nanometer of titanium-based external surface
Pipe coating and coated on the antibiotic layer on the TiO2 nanotube coating, the antibiotic layer is coated using PHMG solution.
Preferably, the Titanium base is titanium sheet or stud.
The present invention also provides the preparation processes of above-mentioned substrate, include the following steps:
S-1. the pretreatment of Titanium base: Titanium base is after pickling, polishing, successively through acetone, washes of absolute alcohol processing, for use；
S-2. anodic oxidation reactions: constant-voltage DC source power supply, using two electrode systems, anode, which connects, is used to prepare nanotube battle array
The Titanium base of column, cathode connect platinum electrode, obtain the Titanium base of the coating of nanotube containing TiO2；Electrolyte quota: it weighs
0.0335gTiO2(0.3wt%) it is dissolved in 2.2ml(2wt%) in deionized water, after its dissolution, add 98ml ethylene glycol, magnetic force
Blender stirs 10min to get electrolyte；
S-3. it after the Titanium base of the coating of nanotube containing TiO2 cleans up, is placed under vacuum, after room temperature degassing for 24 hours, using PHMG
Solution is coated on the Titanium base of the coating of nanotube containing TiO2, is subsequently placed under vacuum dry；
S-4. it after rinsing titanium plate surface with phosphate buffer solution, is dried in vacuo, obtains substrate.
Preferably, in step S-3, after Titanium base is removed from electrode, it is ultrasonically treated respectively with ethyl alcohol and deionized water
5min obtains the Titanium base of the coating of nanotube containing TiO2 after dry.
Preferably, step S-3 is repeated 3-5 times.
Preferably, anodic oxidation reactions voltage uses 18-22V.
It is found by the applicant that the size of voltage will affect the caliber for being formed by nanotube, caliber is smaller, loads drug solution
The biggish resistance of Shi Huiyou is not suitable as carrying the TiO2 nanotube cladding material of medicine, and caliber is larger, is suitable as pharmaceutical carrier
Material, but since voltage is higher, the nanotube coatings on surface are not secured enough, after ultrasonic treatment, the nanotube coatings meeting portion on surface
Divide and falls off.Within this range, pipe diameter size is suitable for voltage.
Further preferably, voltage swing 20V.Caliber under preparing under 20V voltage is 46.4 ± 5.9 nm, and nanotube
Coating is relatively firm.
Preferably, pickling uses hydrofluoric acid.
By implementation above-mentioned technical proposal, novel environment-friendly antibacterial agent PHMG is carried on TiO2 nanotube, it can be sharp simultaneously
Superiority of the PHMG as the superiority and TiO2 nanotube of antibacterial agent as load is used, to be from artificial prosthesis material
Periprosthetic infection provides new direction after aspect prevents artificial joint replacement.And by the improvement to preparation process, in titanium
On matrix, the rounded structure of TiO2 nanotube, size is more uniform, and arrangement is more regular, and caliber is suitable, is suitable as the carrier of PHMG
The nanotube coatings of material, surface are secured, will not fall off.
Detailed description of the invention
Attached drawing 1a-1e is the SEM picture of TiO2 nanotube under different voltages.
Specific embodiment
In conjunction with implementing in detail below, the present invention is described in further detail, and protection content of the invention is not limited to
Following embodiment.Without departing from the spirit and scope of the invention, various changes and advantages that will be apparent to those skilled in the art
It is all included in the present invention, and with appended claims protection scope.Implement process of the invention, condition, reagent, reality
Proved recipe method etc. is among the general principles and common general knowledge in the art, the present invention is not special in addition to the following content specially referred to
Limit content.
Embodiment 1:
A kind of preparation process for the substrate of prosthese after artificial joint replacement, includes the following steps:
S-1. the pretreatment of Titanium base: titanium sheet through hydrofluoric acid pickling, respectively with 1000 mesh, 2000 mesh, 3000 mesh, 5000 mesh,
After the polishing of 7000 mesh sand paper, successively through acetone, washes of absolute alcohol processing, for use；
S-2. anodic oxidation reactions: constant-voltage DC source power supply, voltage 20v, using two electrode systems, anode, which connects, to be used to prepare
The Titanium base of nano-tube array, cathode connect platinum electrode, obtain the Titanium base of the coating of nanotube containing TiO2；Electrolyte quota: it weighs
0.0335g(0.3wt%) it is dissolved in 2.2ml(2wt%) in deionized water, after its dissolution, add 98ml ethylene glycol, magnetic agitation
Device stirs the 10min organic electrolyte used to get this experiment；
S-3. it after the Titanium base of the coating of nanotube containing TiO2 cleans up, is placed under vacuum, after room temperature degassing for 24 hours, using PHMG
Solution is coated on the Titanium base of the coating of nanotube containing TiO2, is subsequently placed under vacuum and is dried, and repetitive operation 5 times；
S-4. it after rinsing titanium plate surface with phosphate buffer solution, is dried in vacuo, obtains substrate.
Embodiment 2:
A kind of preparation process for the substrate of prosthese after artificial joint replacement, includes the following steps:
S-1. the pretreatment of Titanium base: stud through hydrofluoric acid pickling, respectively with 1000 mesh, 2000 mesh, 3000 mesh, 5000 mesh,
After the polishing of 7000 mesh sand paper, successively through acetone, washes of absolute alcohol processing, for use；
S-2. anodic oxidation reactions: constant-voltage DC source power supply, voltage 18v, using two electrode systems, anode, which connects, to be used to prepare
The Titanium base of nano-tube array, cathode connect platinum electrode, obtain the Titanium base of the coating of nanotube containing TiO2；Electrolyte quota: it weighs
0.0335g(0.3wt%) it is dissolved in 2.2ml(2wt%) in deionized water, after its dissolution, add 98ml ethylene glycol, magnetic agitation
Device stirs the 10min organic electrolyte used to get this experiment；
S-3. it after the Titanium base of the coating of nanotube containing TiO2 cleans up, is placed under vacuum, after room temperature degassing for 24 hours, using PHMG
Solution is coated on the Titanium base of the coating of nanotube containing TiO2, is subsequently placed under vacuum and is dried, and repetitive operation 5 times；
S-4. it after rinsing stud surface with phosphate buffer solution, is dried in vacuo, obtains substrate.
Comparative example 1:
It is with the difference of embodiment 1, voltage 10v.
Comparative example 2:
It is with the difference of embodiment 1, voltage 15v.
Comparative example 3:
It is with the difference of embodiment 1, voltage 25v.
Comparative example 4:
It is with the difference of embodiment 1, voltage 30v.
The pipe diameter size measurement of embodiment 1 and comparative example 1-4 gained TiO2 nanotube, the results are shown in Table 1:
The Titanium base containing TiO2 nanotube coating point that embodiment 1 and comparative example 1-4 obtain is fixed on SEM with conductive tape
It on objective table, after vacuum metal spraying 30s, is placed under scanning electron microscope and is observed, SEM figure is shown in attached drawing 1a-1e respectively.
Claims (10)
1. a kind of substrate for prosthese after artificial joint replacement, which is characterized in that including Titanium base, be overlying on Titanium base appearance
The TiO in face2Nanotube coating and be coated on the TiO2Antibiotic layer on nanotube coating, the antibiotic layer are molten using PHMG
Liquid coats.
2. a kind of substrate for prosthese after artificial joint replacement according to claim 1, which is characterized in that the titanium-based
Body is titanium sheet or stud.
3. a kind of preparation process for the substrate of prosthese after artificial joint replacement as described in claim 1, including walk as follows
It is rapid:
S-1. the pretreatment of Titanium base: Titanium base is after pickling, polishing, successively through acetone, washes of absolute alcohol processing, for use；
S-2. anodic oxidation reactions: constant-voltage DC source power supply, using two electrode systems, anode, which connects, is used to prepare nanotube battle array
The Titanium base of column, cathode meet platinum electrode, TiO2Under electrolyte, obtain containing TiO2The Titanium base of nanotube coating；
S-3. contain TiO2It after the Titanium base of nanotube coating cleans up, is placed under vacuum, after room temperature degassing, using PHMG solution
It is coated to containing TiO2On the Titanium base of nanotube coating, it is subsequently placed under vacuum dry；
S-4. it after rinsing titanium plate surface with phosphate buffer solution, is dried in vacuo, obtains substrate.
4. a kind of preparation process for the substrate of prosthese after artificial joint replacement, feature exist according to claim 3
In after Titanium base is removed from electrode, being ultrasonically treated, obtained after dry containing TiO with ethyl alcohol and deionized water respectively in step S-32
The Titanium base of nanotube coating.
5. a kind of preparation process for the substrate of prosthese after artificial joint replacement, feature exist according to claim 3
In step S-3 is repeated 3-5 times.
6. a kind of preparation process for the substrate of prosthese after artificial joint replacement, feature exist according to claim 3
In anodic oxidation reactions voltage uses 18-22V.
7. a kind of preparation process for the substrate of prosthese after artificial joint replacement, feature exist according to claim 3
In room temperature deaerates for 24 hours.
8. a kind of preparation process for the substrate of prosthese after artificial joint replacement, feature exist according to claim 3
In ultrasonic treatment 3-8min.
9. a kind of preparation process for the substrate of prosthese after artificial joint replacement, feature exist according to claim 3
In pickling uses hydrofluoric acid.
10. a kind of preparation process for the substrate of prosthese after artificial joint replacement, feature exist according to claim 3
In electrolyte quota: TiO2Be dissolved in deionized water, after its dissolution, add ethylene glycol, magnetic stirrer to get
Electrolyte.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115399333A (en) * | 2022-09-20 | 2022-11-29 | 江苏集萃先进纤维材料研究所有限公司 | Preparation method and application of antibacterial nano composite material |
| CN115779143A (en) * | 2022-11-11 | 2023-03-14 | 山东大学 | Titanium-based implant and preparation method and application thereof |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101311329A (en) * | 2008-02-20 | 2008-11-26 | 福建师范大学 | Method for preparing titanium oxide nanotube array bone repair biomaterial with biological activity |
| CN101857638A (en) * | 2010-05-25 | 2010-10-13 | 北京化工大学 | Method for preparing bovine hemoglobin/titanium-based titanium dioxide hybrid material |
| CN103007347A (en) * | 2012-11-26 | 2013-04-03 | 上海交通大学 | Method for loading gentamicin by using TiO2 nanotube coating in situ synthesized on Ti surface |
| CN104436313A (en) * | 2013-09-12 | 2015-03-25 | 上海交通大学医学院附属第九人民医院 | Growth factor nanotube slow-release system used for osseointegration and preparation method and application thereof |
| KR20180098513A (en) * | 2018-08-28 | 2018-09-04 | 전남대학교산학협력단 | Method for treating surface of Titanium implant |
-
2019
- 2019-07-29 CN CN201910689296.5A patent/CN110354304A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101311329A (en) * | 2008-02-20 | 2008-11-26 | 福建师范大学 | Method for preparing titanium oxide nanotube array bone repair biomaterial with biological activity |
| CN101857638A (en) * | 2010-05-25 | 2010-10-13 | 北京化工大学 | Method for preparing bovine hemoglobin/titanium-based titanium dioxide hybrid material |
| CN103007347A (en) * | 2012-11-26 | 2013-04-03 | 上海交通大学 | Method for loading gentamicin by using TiO2 nanotube coating in situ synthesized on Ti surface |
| CN104436313A (en) * | 2013-09-12 | 2015-03-25 | 上海交通大学医学院附属第九人民医院 | Growth factor nanotube slow-release system used for osseointegration and preparation method and application thereof |
| KR20180098513A (en) * | 2018-08-28 | 2018-09-04 | 전남대학교산학협력단 | Method for treating surface of Titanium implant |
Non-Patent Citations (2)
| Title |
|---|
| 王桂芳等: "TiO2纳米管负载聚六亚甲基胍促进种植体钛表面成骨分化性能的研究", 《口腔医学》 * |
| 肖建德等: "《临床骨科新理论和新技术》", 31 October 2003, 湖南科学技术出版社 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115399333A (en) * | 2022-09-20 | 2022-11-29 | 江苏集萃先进纤维材料研究所有限公司 | Preparation method and application of antibacterial nano composite material |
| CN115779143A (en) * | 2022-11-11 | 2023-03-14 | 山东大学 | Titanium-based implant and preparation method and application thereof |
| CN115779143B (en) * | 2022-11-11 | 2024-02-13 | 山东大学 | Titanium-based implant, and preparation method and application thereof |
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Application publication date: 20191022 |