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CN110301938A - Probe and tissue elasticity detection system - Google Patents

Probe and tissue elasticity detection system Download PDF

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Publication number
CN110301938A
CN110301938A CN201910635652.5A CN201910635652A CN110301938A CN 110301938 A CN110301938 A CN 110301938A CN 201910635652 A CN201910635652 A CN 201910635652A CN 110301938 A CN110301938 A CN 110301938A
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China
Prior art keywords
probe
array element
array
work
signal
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CN201910635652.5A
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Chinese (zh)
Inventor
焦建华
邵金华
孙锦
段后利
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Wuxi Hisky Medical Technologies Co Ltd
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Wuxi Hisky Medical Technologies Co Ltd
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Priority to CN201910635652.5A priority Critical patent/CN110301938A/en
Publication of CN110301938A publication Critical patent/CN110301938A/en
Priority to PCT/CN2020/090552 priority patent/WO2021008218A1/en
Pending legal-status Critical Current

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/44Constructional features of the ultrasonic, sonic or infrasonic diagnostic device
    • A61B8/4444Constructional features of the ultrasonic, sonic or infrasonic diagnostic device related to the probe
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/44Constructional features of the ultrasonic, sonic or infrasonic diagnostic device
    • A61B8/4483Constructional features of the ultrasonic, sonic or infrasonic diagnostic device characterised by features of the ultrasound transducer
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/44Constructional features of the ultrasonic, sonic or infrasonic diagnostic device
    • A61B8/4483Constructional features of the ultrasonic, sonic or infrasonic diagnostic device characterised by features of the ultrasound transducer
    • A61B8/4494Constructional features of the ultrasonic, sonic or infrasonic diagnostic device characterised by features of the ultrasound transducer characterised by the arrangement of the transducer elements
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/48Diagnostic techniques
    • A61B8/485Diagnostic techniques involving measuring strain or elastic properties
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/54Control of the diagnostic device
    • A61B8/543Control of the diagnostic device involving acquisition triggered by a physiological signal

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pathology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Gynecology & Obstetrics (AREA)
  • Physiology (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
  • Investigating Or Analyzing Materials By The Use Of Ultrasonic Waves (AREA)

Abstract

The present invention relates to a kind of probe and tissue elasticity detection system, probe includes shearing wave producer, drives through low-frequency excitation signal and generates low frequency shear waves;Transducer array, it is converted for acoustic-electric, it includes array element component, the array element component is for realizing ultrasound imaging mode or parameter detecting mode detection, the array element component includes the first work array element and the second work array element, it is described first work array element for realizing ultrasound imaging mode imaging function, it is described second work array element for realizing parameter detecting mode parameter detecting function.The probe is changed without probe to reach switching ultrasound imaging mode or parameter detecting mode and then realize, ultrasound mode and elastic model switching can be realized by the first work array element of switching and the second work array element.

Description

Probe and tissue elasticity detection system
Technical field
The present invention relates to elastomeric check technologies, more particularly to probe and tissue elasticity detection system.
Background technique
Transient elastography technology (Transient Elastography) is a kind of quantitative determination tissue elasticity modulus Technology.The technology emits low frequency shear waves to detection site by body surface, and shearing wave propagates speed in the tissue of different hardness Degree have it is significantly different, by detection shearing velocity of wave propagation can be with computation organization's hardness of accurate quantitative analysis.Transient elastography skill Art can not know the organizational information of detection zone, and the two-dimensional structure information especially organized, technician is typically only capable to according to warp It tests to be arranged and arrange one group of ultrasonic probe for Transient elastography.Therefore, when carrying out elastomeric check, if inside contains When the factor for having big blood vessel, tumour or ascites etc. to will affect elastomeric check result accuracy, detection will be generated because that can not avoid Error.
It exists in the prior art and selects suitable diagnostic position and angle with Ultrasonic-B probe, then change the super probe of E and surveyed The way of diagnosis is measured, but replaces selection and measurement diagnosis that probe carries out diagnostic position, can't be made marks in human body, no It can guarantee the completely the same of sound head corresponding position, the offset of position will cause the deviation of diagnostic data.
Summary of the invention
Based on this, it is necessary to during for the selection and measurement diagnosis for carrying out diagnostic position, can there is diagnostic data The problem of deviation, provides a kind of pop one's head in and tissue elasticity detection system.
A kind of probe, is able to carry out image checking and parameter detecting, comprising: shearing wave producer, through low-frequency excitation signal Driving generates low frequency shear waves;Transducer array is converted for acoustic-electric comprising array element component, the array element component is for real Existing ultrasound imaging mode or parameter detecting mode detection, the array element component include the first work array element and the second work battle array Member, the first work array element is for realizing the imaging function of ultrasound imaging mode, and the second work array element is for realizing ginseng The parameter detecting function of number detection pattern.
The second work array element is one or more array elements in one of the embodiments,;The first work array element For more than two array elements.
The shearing wave producer drives probe vibration, the vibration frequency model of the probe in one of the embodiments, It encloses are as follows: 1-1000Hz.
The frequency bandwidth of the probe is determined by the response frequency of object to be measured in one of the embodiments,.
The range of frequency bandwidths of the probe is 0.5-50MHz in one of the embodiments,.
In one of the embodiments, in the array element component between each array element spacing by the probe investigation depth and spy Measuring angle determines.
Spacing range is 0.01-20mm between each array element in the array element component in one of the embodiments,.
The probe includes that linear array probe, phased array probe, face battle array probe or convex battle array are visited in one of the embodiments, One of head.
The probe radius is determined by the investigation depth and detection angle of the probe in one of the embodiments,.
The probe radius range is 0.5-100mm in one of the embodiments,.
The probe distal end thickness is less than or equal to 20mm in one of the embodiments,.
A kind of tissue elasticity detection system, including organizational parameter detection module, image-forming module, control module and above-mentioned A kind of probe: the organizational parameter detection module, for organizational parameter detection letter to be generated and handled according to control instruction Number;The image-forming module, for imaging signal to be generated and handled according to control instruction;The control module is joined with the tissue Number detection module, the image-forming module and it is described probe be connected, for control it is described probe enter parameter detecting mode or Imaging pattern, and control instruction is sent to the organizational parameter detection module or image-forming module.
The control module includes switching control submodule in one of the embodiments, the switching control submodule Switch between the organizational parameter detection pattern and the imaging hyper mode for controlling the probe.
Above-mentioned probe and tissue elasticity detection system, including shearing wave producer and transducer array.Shearing wave occurs Device drives through low-frequency excitation signal generates low frequency shear waves, and transducer array is converted comprising array element component, institute for acoustic-electric Array element component is stated for realizing ultrasound imaging mode or parameter detecting mode detection, the array element component includes the first work array element And second work array element, it is described first work array element for realizing ultrasound imaging mode imaging function, it is described second work Array element for realizing parameter detecting mode parameter detecting function.The probe passes through switching the first work array element and second Work array element, is changed without probe to reach switching ultrasound imaging mode or parameter detecting mode and then realize, can be realized super Sound pattern and elastic model switching.
Detailed description of the invention
Fig. 1 is the tissue elasticity detection system block diagram of the embodiment of the present invention.
Specific embodiment
As shown in Figure 1, a kind of tissue elasticity detection system 10, including organizational parameter detection module 110, image-forming module 120, Control module 130, and probe 20: the organizational parameter detects mould 110, for tissue ginseng to be generated and handled according to control instruction Number detection signal;The image-forming module 120, for imaging signal to be generated and handled according to control instruction;The control module 130, it is connected with the organizational parameter detection module 110, the image-forming module 120 and the probe 20, it is described for controlling Probe enters parameter detecting mode or imaging pattern, and sends out to the organizational parameter detection module 110 or image-forming module 120 Send control instruction.
As shown in Figure 1, the organizational parameter detection module 110 is used to that organizational parameter inspection to be generated and handled according to control instruction Signal is surveyed, the probe 20 drives the probe 20 according to the first pumping signal of the organizational parameter detection module 110 transmitting Generate low frequency shear waves, and then quantitative determination tissue elasticity modulus.The organizational parameter detection module 110 includes at the first control Manage device 111 and shearing wave driver 112, the first signal amplifier 113, the first analog-digital converter 114, the first signal projector 115 and pressure detecting processor 116.The wherein frequency range of the low frequency shear waves are as follows: 1-1000Hz;The low frequency shear The amplitude range of wave are as follows: 0.1-50mm.
First control processor 111 is connect with the shearing wave driver 112, first control processor 111 For generating the first pumping signal according to control instruction, and first pumping signal is transmitted to shearing wave driver 112, institute Shearing wave driver 112 is stated for receiving first pumping signal, processing is amplified to the pumping signal, at amplification First pumping signal after reason is transmitted to probe 20.The first pumping signal excitation probe 20 generates low frequency shear Wave.First control processor 111 is connect with first signal projector 115, and first control processor 111 emits Second pumping signal, and it is transmitted to first signal projector 115, first signal projector 115 swashs the high pressure Signal is encouraged to be transmitted to the probe 20 and then probe 20 is driven to generate ultrasonic signal.First control processor 111 with it is described First analog-digital converter 114, the first signal amplifier 113 are sequentially connected, and the echo-signal of 20 detection of probe is through described the After one signal amplifier 113 carries out signal amplification, the analog signal is converted to digital letter by first analog-digital converter 114 Number, the digital data transmission to first control processor 111, first control processor 111 is to the number received It is operated according to data conversion, processing, filtering etc. is carried out.The pressure detecting processor 116 connects with first control processor 111 It connects, the pressure detecting processor 116 will test 20 pressure values that contact with contact site of probe, be transmitted to described the Pressure value is transmitted to display device and shown by one control processor 111, first control processor 111, is convenient for user Real-time monitoring.
In the present embodiment, first control processor 111 is field-programmable gate array (Field- Programmable Gate Array:FPGA) plate.The FPGA generates the second pumping signal, the second pumping signal driving Probe 20 generates ultrasonic signal.The FPGA sends the second pumping signal, and first pumping signal drives through the shearing wave Device 112 carries out signal amplification, and then first pumping signal excitation probe 20 generates low frequency shear waves.The low frequency is cut It cuts wave spread speed difference, ultrasonic signal in different hardness tissue and carries the spread speed information of first shearing wave It is transmitted to the organizational parameter detection module 110, and then computation organization's hardness of accurate quantitative analysis.
The image-forming module 120, which is generated, generates according to control instruction and handles imaging signal, described in the imaging signal warp Probe 20 issues, and for accurately being positioned, and then is the proper diagnosis of the organizational parameter detection module 110 selection detection Position and angle.The image-forming module 120 includes the second control processor 121, second signal amplifier 122, the second modulus turn Parallel operation 123 and second signal transmitter 124, second control processor 121 connect with the second signal transmitter 124 It connects, second control processor 121 sends driving pulse to the second signal transmitter 124, the second signal transmitting The driving pulse is transferred to the probe 20 and then probe 20 is driven to generate ultrasonic signal by device 124.At second control Reason device 121 is sequentially connected with second analog-digital converter 123, second signal amplifier 122, for handling ultrasonic echo letter Number, that is, the ultrasound echo signal of 20 detection of probe is received after the second signal amplifier 122 carries out signal amplification, institute It states the second analog-digital converter 123 and the analog signal is converted into digital signal, the digital data transmission to second control Processor 121 processed.
In the present embodiment, second control processor 121 is field-programmable gate array (Field- Programmable Gate Array:FPGA) plate.Certainly according to the design needs, first control processor 111 with it is described Second control processor 121 can any one for STM32 single-chip microcontroller, in ARM chip, as long as can be realized data processing, right The control of its associated components sends the first pumping signal and the second pumping signal.
The control module 130 detects signal and the imaging signal for handling the organizational parameter, and according to described Organizational parameter detects signal and the imaging signal control probe 20 carries out organizational parameter detection pattern or imaging pattern Detection, the control module 130 include switching control submodule 131, probe switch unit 132 and array element switch unit 133, institute It states probe switch unit 132 20 to connect and can be to 20 output signal pulses of the probe with described pop one's head in, while realizing difference It detects under object (physical feelings such as detection liver, thoracic cavity), the switching of probe, the switching control submodule 131 is for controlling institute Probe 20 is stated to switch between the organizational parameter detection pattern and the imaging pattern.The switching control submodule 131 wraps Change-over switch is included, the change-over switch is used for the parameter detection module 110 or the image-forming module 120 and the probe 20 Connection.The control signal that the array element switch unit 133 is sent according to the control module 130 is carried out corresponding to imaging pattern First work array element and corresponding to parameter detecting mode second work array element between switching.
Probe 20, integration imaging detection pattern and parameter detecting mode, including shearing wave producer 210, pressure detector 220 and transducer array 230, the shearing wave producer 210 drives through low-frequency excitation signal and generates low frequency shear waves, the pressure Force detector 220 is used to detect the pressure size of 20 pairs of its contacts site of the probe, and the transducer array 230 is used for sound (ultrasonic signal) electric signal changes.Wherein, the pressure value information that the pressure detector 220 will test passes to the organizational parameter Pressure detecting processor 116 in detection module 110, the pressure detecting processor 116 pass to pressure value information described First control processor 111, and then realize the pressure information between the position that 20 are in contact with it of popping one's head in described in real-time monitoring.At this In embodiment, the transducer array 230 includes array element component 231, and the array element component 231 is piezo ceramic element, is used for Sound (ultrasonic signal) electricity (electric signal) conversion.The array element component 231 includes the first work array element 2311 and the second work battle array Member 2312, the first work array element 2311 is for realizing the imaging function for realizing ultrasound imaging mode, the second work battle array Member 2312 for realizing parameter detecting mode parameter detecting function.
The second work array element is one or more array elements;The first work array element is more than two array elements.It is described The array number of first work array element 2311 is N array element, and the second work array element 2312 is the first work array element 2311 The array number of subset, the second work array element 2312 is n.In the present embodiment, the array element of the first work array element 2311 Number is 64 array elements, and according to the design needs, the array number of the second work array element 2312 chooses the first work array element 2311 Array number middle position, and then it is described second work array element 2312 array number be 16 array elements.It is according to theory it is found that described The array number of first work array element 2311 can be any combination array number of 64 array elements into 128 array elements.Similarly, second work Make array element 2312 to be adjusted accordingly according to the array number of the first work array element 2311, i.e., the described second work array element 2312 Array number can be any combination array number of 6 array elements into 16 array elements.
It shears wave producer and drives probe vibration, the vibration frequency range of the probe are as follows: 1-1000Hz.
Array element design principle: spacing is smaller between each array element, and potsherd is thinner, and frequency is higher, is lost bigger.
In the present embodiment, according to the investigation depth and detection angle of the probe, each battle array in the array element component is determined Spacing is 0.01-20mm between member, according to the response frequency for wanting detection position, determines that the frequency bandwidth of the probe is 0.5- 50MHz, centre frequency 2.5M determine that the probe radius is 0.5-according to the investigation depth and detection angle of the probe 100mm.The probe distal end thickness is less than or equal to 20mm.It is described probe include linear array probe, phased array probe, face battle array probe or One of person's convex array probe.
The tissue elasticity detection system integrates ultrasound detection mode and elastomeric check mode, and then integrated images guide function It can be with elastomeric check function.After going out optimum position using image-guided functional localization, switches to elastomeric check mode and start bullet Property detection function, realize elastomeric check.Probe 20 using realize is changed without probe, not will cause positional shift, can accurately, It is easy, efficient to realize tissue elasticity detection.
When probe 20 realizes image-guided function, the control module 130 sends control signal and controls the energy converter Array opens N number of array element component, into imaging pattern, meanwhile, the control module sends control signal and is transmitted to the array element Switch unit 133, the 20 first work array element 2311 of the control of array element switch unit 133 probe works, at second control It manages device 121 and sends driving pulse to the second signal transmitter 124, the second signal transmitter 124 is by the driving arteries and veins Punching is transferred to the probe 20 and then drives the transducer array 230 in probe 20, the first work in the transducer array 230 Make 2311 excited target of array element and be generated and transmitted by ultrasonic wave, and then the position for carrying out object to be measured is detected.The ultrasonic wave Echo-signal is received through the probe 20, turns the echo-signal through the first work array element 2311 in transducer array 230 It is changed to electric signal, and is transmitted to the image-forming module 120, the second signal amplifier 122 in the image-forming module 120 will be described Second analog-digital converter 123 is transmitted to after electric signal amplification and carries out analog-to-digital conversion, by digital signal to second control Processor 121, after second control processor 121 carries out the operation such as data conversion, processing, filtering to the digital signal, Treated that digital data transmission to display device is shown by described, obtains ultrasound detection image.
When probe 20 realizes elastomeric check function, the control module 130 sends control signal and controls the energy converter Array opens n array element component, into elastomeric check mode.Meanwhile the control module send control signal be transmitted to it is described Array element switch unit 133,20 second work array elements 2312 of the array element switch unit 133 control probe work, at this point, described the Multiple array elements are in parallel in two work array elements 2312, are equivalent to one array element of synthesis, the first control of the elastomeric check module 110 Processor 111 sends low-frequency excitation signal extremely probe 20, the second work 2312 excited target of array element in the probe 20, and then drives Shearing wave producer 210 in dynamic probe 20 generates low frequency shear waves, at the first control of the organizational parameter detection module 110 After the reason transmission high pressure activation signal of device 111 is transmitted to the probe 20, the high pressure activation signal drives the transducer array The second work array element 2312 in 230, is generated and transmitted by ultrasonic wave, to track movement of the low frequency shear waves in test serum. The transducer array 230 receives the echo of the ultrasonic wave, and the echo is converted into electric signal by the second work array element 2312, The electric signal is transmitted to first analog-digital converter after the amplification of the first signal amplifier 113 of elastomeric check module 110 114 carry out analog-to-digital conversion, by the first control processor 111 of digital signal to the elastomeric check module 110, first control After processor 111 processed carries out digital processing, conversion and filtering to the digital signal, it is transmitted to the display device and is shown Show, and then obtains tissue elasticity testing result.
Each technical characteristic of embodiment described above can be combined arbitrarily, for simplicity of description, not to above-mentioned reality It applies all possible combination of each technical characteristic in example to be all described, as long as however, the combination of these technical characteristics is not deposited In contradiction, all should be considered as described in this specification.
The embodiments described above only express several embodiments of the present invention, and the description thereof is more specific and detailed, but simultaneously It cannot therefore be construed as limiting the scope of the patent.It should be pointed out that coming for those of ordinary skill in the art It says, without departing from the inventive concept of the premise, various modifications and improvements can be made, these belong to protection of the invention Range.Therefore, the scope of protection of the patent of the invention shall be subject to the appended claims.

Claims (13)

1. a kind of probe, is able to carry out image checking and parameter detecting characterized by comprising
Wave producer is sheared, is driven through low-frequency excitation signal and generates low frequency shear waves;
Transducer array is converted for acoustic-electric comprising array element component, the array element component for realizing ultrasound imaging mode or Parameter detecting mode detection, the array element component include the first work array element and the second work array element, the first work battle array Member for realizing ultrasound imaging mode imaging function, it is described second work array element for realizing parameter detecting mode parameter examine Brake.
2. probe according to claim 1, which is characterized in that the second work array element is one or more array elements;Institute The first work array element is stated as more than two array elements.
3. probe according to claim 1, which is characterized in that
The shearing wave producer drives probe vibration, the vibration frequency range of the probe are as follows: 1-1000Hz.
4. probe according to claim 1, which is characterized in that the frequency bandwidth of the probe by object to be measured response frequency Rate determines.
5. probe as claimed in claim 4, which is characterized in that
The range of frequency bandwidths of the probe is 0.5-50MHz.
6. probe according to claim 1, which is characterized in that in the array element component between each array element spacing by the probe Investigation depth and detection angle determine.
7. probe as claimed in claim 6, which is characterized in that
Spacing range is 0.01-20mm between each array element in the array element component.
8. probe according to claim 1, which is characterized in that the probe includes linear array probe, phased array probe, face battle array One of probe or convex array probe.
9. probe according to claim 1, which is characterized in that
The probe radius is determined by the investigation depth and detection angle of the probe.
10. probe according to claim 9, which is characterized in that
The probe radius range is 0.5-100mm.
11. probe according to claim 1, which is characterized in that the probe distal end thickness is less than or equal to 20mm.
12. a kind of tissue elasticity detection system, which is characterized in that including organizational parameter detection module, image-forming module, control module And probe described in any one of claims 1 to 11:
The organizational parameter detection module detects signal for organizational parameter to be generated and handled according to control instruction;
The image-forming module, for imaging signal to be generated and handled according to control instruction;
The control module is connected, for controlling with the organizational parameter detection module, the image-forming module and the probe The probe enters parameter detecting mode or imaging pattern, and sends to the organizational parameter detection module or image-forming module Control instruction.
13. tissue elasticity detection system according to claim 12, which is characterized in that
The control module includes switching control submodule, and the switching control submodule is for controlling the probe at described group It knits and switches between parameter detecting mode and the imaging hyper mode.
CN201910635652.5A 2019-07-15 2019-07-15 Probe and tissue elasticity detection system Pending CN110301938A (en)

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PCT/CN2020/090552 WO2021008218A1 (en) 2019-07-15 2020-05-15 Probe and tissue elasticity measurement system

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