CN110236087A - A kind of processing method of health-care flour - Google Patents
A kind of processing method of health-care flour Download PDFInfo
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- CN110236087A CN110236087A CN201910416779.8A CN201910416779A CN110236087A CN 110236087 A CN110236087 A CN 110236087A CN 201910416779 A CN201910416779 A CN 201910416779A CN 110236087 A CN110236087 A CN 110236087A
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- Prior art keywords
- health
- radix glycyrrhizae
- flour
- processing method
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- 235000013312 flour Nutrition 0.000 title claims abstract description 38
- 238000003672 processing method Methods 0.000 title claims abstract description 23
- 229920001282 polysaccharide Polymers 0.000 claims abstract description 27
- 239000005017 polysaccharide Substances 0.000 claims abstract description 27
- 150000004676 glycans Chemical class 0.000 claims abstract description 26
- 241000202807 Glycyrrhiza Species 0.000 claims abstract description 25
- 235000001453 Glycyrrhiza echinata Nutrition 0.000 claims abstract description 25
- 235000006200 Glycyrrhiza glabra Nutrition 0.000 claims abstract description 25
- 235000017382 Glycyrrhiza lepidota Nutrition 0.000 claims abstract description 25
- 229940010454 licorice Drugs 0.000 claims abstract description 25
- 229930194248 Licoflavone Natural products 0.000 claims abstract description 12
- MEHHCBRCXIDGKZ-UHFFFAOYSA-N Licoflavone C Natural products CC(C)=CCC1=C(O)C=C(O)C(C(C=2)=O)=C1OC=2C1=CC=C(O)C=C1 MEHHCBRCXIDGKZ-UHFFFAOYSA-N 0.000 claims abstract description 12
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 11
- 239000002502 liposome Substances 0.000 claims abstract description 9
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 40
- 239000000243 solution Substances 0.000 claims description 30
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims description 16
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 claims description 14
- 235000019441 ethanol Nutrition 0.000 claims description 14
- 229960004756 ethanol Drugs 0.000 claims description 13
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 11
- 235000012000 cholesterol Nutrition 0.000 claims description 8
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims description 8
- 229920000053 polysorbate 80 Polymers 0.000 claims description 8
- 238000001914 filtration Methods 0.000 claims description 7
- JLPULHDHAOZNQI-ZTIMHPMXSA-N 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCC\C=C/C\C=C/CCCCC JLPULHDHAOZNQI-ZTIMHPMXSA-N 0.000 claims description 6
- 238000001816 cooling Methods 0.000 claims description 6
- 239000012153 distilled water Substances 0.000 claims description 6
- 239000007788 liquid Substances 0.000 claims description 6
- 239000008363 phosphate buffer Substances 0.000 claims description 6
- 230000001376 precipitating effect Effects 0.000 claims description 6
- 229940083466 soybean lecithin Drugs 0.000 claims description 6
- 238000002137 ultrasound extraction Methods 0.000 claims description 6
- 238000000605 extraction Methods 0.000 claims description 4
- 239000000203 mixture Substances 0.000 claims description 4
- 238000003756 stirring Methods 0.000 claims description 4
- 239000012141 concentrate Substances 0.000 claims description 3
- 238000011109 contamination Methods 0.000 claims description 3
- 239000000839 emulsion Substances 0.000 claims description 3
- 239000000284 extract Substances 0.000 claims description 3
- 238000010438 heat treatment Methods 0.000 claims description 3
- 239000005457 ice water Substances 0.000 claims description 3
- 239000012982 microporous membrane Substances 0.000 claims description 3
- 239000011259 mixed solution Substances 0.000 claims description 3
- 238000001556 precipitation Methods 0.000 claims description 3
- 238000002360 preparation method Methods 0.000 claims description 3
- 238000002604 ultrasonography Methods 0.000 claims description 3
- 239000000654 additive Substances 0.000 claims description 2
- 230000000996 additive effect Effects 0.000 claims description 2
- 235000009508 confectionery Nutrition 0.000 claims description 2
- 229960000935 dehydrated alcohol Drugs 0.000 claims description 2
- 238000004806 packaging method and process Methods 0.000 claims description 2
- 238000001291 vacuum drying Methods 0.000 claims description 2
- 238000005406 washing Methods 0.000 claims description 2
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 claims 2
- 235000010445 lecithin Nutrition 0.000 claims 2
- 229940067606 lecithin Drugs 0.000 claims 2
- 239000000787 lecithin Substances 0.000 claims 2
- 244000025254 Cannabis sativa Species 0.000 claims 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims 1
- 229910052801 chlorine Inorganic materials 0.000 claims 1
- 239000000460 chlorine Substances 0.000 claims 1
- 235000013305 food Nutrition 0.000 abstract description 7
- 230000000840 anti-viral effect Effects 0.000 abstract description 3
- 239000003963 antioxidant agent Substances 0.000 abstract description 3
- 230000003078 antioxidant effect Effects 0.000 abstract description 3
- 230000003110 anti-inflammatory effect Effects 0.000 abstract description 2
- 230000000694 effects Effects 0.000 abstract description 2
- 238000001704 evaporation Methods 0.000 abstract description 2
- 230000008020 evaporation Effects 0.000 abstract description 2
- 230000008821 health effect Effects 0.000 abstract description 2
- 239000008236 heating water Substances 0.000 abstract description 2
- 230000036039 immunity Effects 0.000 abstract description 2
- 230000003647 oxidation Effects 0.000 abstract description 2
- 238000007254 oxidation reaction Methods 0.000 abstract description 2
- 230000001954 sterilising effect Effects 0.000 abstract description 2
- 238000004659 sterilization and disinfection Methods 0.000 abstract description 2
- HIXDQWDOVZUNNA-UHFFFAOYSA-N 2-(3,4-dimethoxyphenyl)-5-hydroxy-7-methoxychromen-4-one Chemical compound C=1C(OC)=CC(O)=C(C(C=2)=O)C=1OC=2C1=CC=C(OC)C(OC)=C1 HIXDQWDOVZUNNA-UHFFFAOYSA-N 0.000 description 5
- -1 triterpene compound Chemical class 0.000 description 3
- 235000006708 antioxidants Nutrition 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- IAJILQKETJEXLJ-UHFFFAOYSA-N Galacturonsaeure Natural products O=CC(O)C(O)C(O)C(O)C(O)=O IAJILQKETJEXLJ-UHFFFAOYSA-N 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- GAMYVSCDDLXAQW-AOIWZFSPSA-N Thermopsosid Natural products O(C)c1c(O)ccc(C=2Oc3c(c(O)cc(O[C@H]4[C@H](O)[C@@H](O)[C@H](O)[C@H](CO)O4)c3)C(=O)C=2)c1 GAMYVSCDDLXAQW-AOIWZFSPSA-N 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- IAJILQKETJEXLJ-QTBDOELSSA-N aldehydo-D-glucuronic acid Chemical compound O=C[C@H](O)[C@@H](O)[C@H](O)[C@H](O)C(O)=O IAJILQKETJEXLJ-QTBDOELSSA-N 0.000 description 1
- 230000000259 anti-tumor effect Effects 0.000 description 1
- 235000015173 baked goods and baking mixes Nutrition 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229930003944 flavone Natural products 0.000 description 1
- 235000011949 flavones Nutrition 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 229940097043 glucuronic acid Drugs 0.000 description 1
- 235000013402 health food Nutrition 0.000 description 1
- 230000001900 immune effect Effects 0.000 description 1
- 229920002521 macromolecule Polymers 0.000 description 1
- 235000013622 meat product Nutrition 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- VHBFFQKBGNRLFZ-UHFFFAOYSA-N vitamin p Natural products O1C2=CC=CC=C2C(=O)C=C1C1=CC=CC=C1 VHBFFQKBGNRLFZ-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L3/00—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs
- A23L3/34—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs by treatment with chemicals
- A23L3/3454—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs by treatment with chemicals in the form of liquids or solids
- A23L3/3463—Organic compounds; Microorganisms; Enzymes
- A23L3/3472—Compounds of undetermined constitution obtained from animals or plants
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/115—Fatty acids or derivatives thereof; Fats or oils
- A23L33/12—Fatty acids or derivatives thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/125—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives containing carbohydrate syrups; containing sugars; containing sugar alcohols; containing starch hydrolysates
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L7/00—Cereal-derived products; Malt products; Preparation or treatment thereof
- A23L7/10—Cereal-derived products
- A23L7/198—Dry unshaped finely divided cereal products, not provided for in groups A23L7/117 - A23L7/196 and A23L29/00, e.g. meal, flour, powder, dried cereal creams or extracts
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
- A23P10/00—Shaping or working of foodstuffs characterised by the products
- A23P10/30—Encapsulation of particles, e.g. foodstuff additives
- A23P10/35—Encapsulation of particles, e.g. foodstuff additives with oils, lipids, monoglycerides or diglycerides
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Polymers & Plastics (AREA)
- Food Science & Technology (AREA)
- Nutrition Science (AREA)
- Mycology (AREA)
- Molecular Biology (AREA)
- Botany (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Medicines Containing Plant Substances (AREA)
- Cosmetics (AREA)
Abstract
The invention discloses a kind of processing methods of health-care flour, licorice polysaccharide is raised by the way that Radix Glycyrrhizae is carried out ultrasonic water, Radix Glycyrrhizae heating water raises antioxidant licoflavone, liposomal licorice polysaccharide is prepared using reverse evaporation simultaneously, keep it more easy to maintain, it is unlikely to deteriorate, extend the shelf-life of flour, licoflavone itself has anti-inflammatory sterilization and oxidation resistant effect, it is worked into flour with licorice polysaccharide liposome, improve the healthcare function of flour, with raising immunity, antiviral effect, but have the function of in the stretching and color for dough it is unfavorable, therefore, it is big that Radix Glycyrrhizae flour is suitable for dough resistance, ductility is small, the food processing that color is not required, the processing method of health-care flour provided by the invention is simple, it is easy to operate, it is at low cost, health properties are good, have a wide range of application, it is worthy to be popularized.
Description
Technical field
The present invention relates to food processing technology field more particularly to a kind of processing methods of health-care flour.
Background technique
Radix Glycyrrhizae is herbaceos perennial, belongs to pulse family, is a kind of dual-purpose of drug and food resource.Physiologically active ingredient master in Radix Glycyrrhizae
There are triterpene compound, flavone compound and licorice polysaccharide class compound three categories.Licorice polysaccharide class compound is mainly
The organic macromolecule polysaccharide of glucose and glucuronic acid composition, licorice polysaccharide have immunological regulation, antitumor, antiviral work
With there is important application value in ordinary food and health food.The antioxygen object of Radix Glycyrrhizae can be applied as antioxidant
Into food such as oil product, meat products, bakery product, dilated foods.Radix Glycyrrhizae antioxygen object has the quality of flour and dough
Important influence, but it is seldom to be added to the report in flour for Radix Glycyrrhizae on the market at present, therefore, the present invention provides a kind of sweet
The processing method of careless health-care flour, to obtain new type of health flour.
Summary of the invention
The object of the invention is to remedy the disadvantages of known techniques, provides a kind of processing method of health-care flour.
The present invention is achieved by the following technical solutions:
A kind of processing method of health-care flour, comprising the following specific steps
(1) Radix Glycyrrhizae is put into medicinal herb grinder and is crushed, crossed 60 meshes, then smashed Radix Glycyrrhizae is added in beaker, then plus
Enter the 9-11 times of distilled water measured, the ultrasonic extraction 30-40min at 35 DEG C of water bath condition is filtered, and is added 9-11 times in filter residue and is measured
Distilled water, after repeating ultrasonic extraction 1 time, merge 2 extracting solutions, be concentrated under reduced pressure on Rotary Evaporators, will after room temperature is cooling
Concentrate is centrifuged 5min with 5000r/min, after discarding contamination precipitation, 95% ethanol solution of 4 times of amounts is slowly added, and constantly
Licorice polysaccharide is precipitated sufficiently in stirring, after standing for 24 hours, is centrifuged 5min again, and obtained licorice polysaccharide precipitating is washed with dehydrated alcohol
It is dry at 60 DEG C after washing 2-3 times；
(2) Radix Glycyrrhizae is put into medicinal herb grinder and is crushed, cross 60 meshes, the ethyl alcohol that smashed Radix Glycyrrhizae is then added to 95% is molten
In liquid, precipitating is washed 1 time with 95% ethanol solution, is repeated by the heating extraction 3-5h at 60-70 DEG C of water-bath, cooling, filtering
It extracts primary, merges extracting solution twice, after concentration plus elutriation goes out to precipitate, and obtains licoflavone using filter, vacuum drying and mentions
Take object；
(3) soybean lecithin, cholesterol and Tween 80 are mixed and is dissolved in the mixed solution of chloroform and ether, ultrasound keeps it sufficiently molten
Solution, is slowly added to the licorice polysaccharide solution for being 4.17mg/mL with the diluted concentration of phosphate buffer, the ultrasonic shape in ice-water bath
It at stable emulsion, is then evaporated under reduced pressure at 46 DEG C to colloidal state is formed, phosphate buffer is added and continues to rotate 10min, most
It is placed in ultrasonic cell disrupte machine and handles 16-20min, intensity 40% opens 2.5s, stops 2.5s, squeezes in 0.45 μm of miillpore filter
Filter 23 time, 0.22 μm filtering with microporous membrane 3 times, obtain licorice polysaccharide liposome solutions；
(4) licoflavone of the licorice polysaccharide liposome solutions prepared in step (3) and step (2) preparation is added in flour,
It stirs and evenly mixs, then handles 45-50min at 105 DEG C in air dry oven, after treatment cooled to room temperature uses
It is stored after ventilating plastic bag packaging at the place of being protected from light no more than 25 DEG C.
A kind of processing method of health-care flour is concentrated under reduced pressure on Rotary Evaporators as described in step (1), wherein be concentrated
Volume is the 1/3 of original volume.
Smashed Radix Glycyrrhizae is added to 95% ethanol solution by a kind of processing method of health-care flour described in step (2)
In, it is measured wherein 95% ethanol solution additive amount is 25-30 times of Radix Glycyrrhizae weight.
A kind of processing method of health-care flour, the weight ratio of soybean lecithin described in step (3), cholesterol and Tween 80
For 80:5:1.
The volume ratio of a kind of processing method of health-care flour, chloroform described in step (3) and ether is 1:2.
A kind of processing method of health-care flour, soybean lecithin described in step (3), cholesterol and Tween 80 mixture
The solid-liquid ratio of weight and chloroform and ether mixed volume is 455mg:12mL.
A kind of processing method of health-care flour, licorice polysaccharide liposome solutions, licoflavone and face described in step (4)
The weight ratio of powder is 4-6:3-5:100.
The invention has the advantages that the present invention raises licorice polysaccharide by the way that Radix Glycyrrhizae is carried out ultrasonic water, Radix Glycyrrhizae heating water is mentioned
Antioxidant licoflavone is obtained, while preparing liposomal licorice polysaccharide using reverse evaporation, keeps it more easy to maintain, no
It is perishable, extend the shelf-life of flour, licoflavone itself has anti-inflammatory sterilization and oxidation resistant effect and licorice polysaccharide lipid
Body is worked into flour, improves the healthcare function of flour, has the function of improving immunity, antiviral, but for dough
Stretching and color on have the function of it is unfavorable, therefore, Radix Glycyrrhizae flour be suitable for dough resistance is big, ductility is small, to color not
The processing method of the food processing being required, health-care flour provided by the invention is simple, easy to operate, at low cost, health properties
It is good, have a wide range of application, is worthy to be popularized.
Specific embodiment
A kind of processing method of health-care flour, comprising the following specific steps
(1) Radix Glycyrrhizae is put into medicinal herb grinder and is crushed, crossed 60 meshes, then smashed Radix Glycyrrhizae is added in beaker, then plus
Entering the distilled water of 9 times of amounts, the ultrasonic extraction 30min at 35 DEG C of water bath condition is filtered, the distilled water of 9 times of amounts are added in filter residue,
After repeating ultrasonic extraction 1 time, merge 2 extracting solutions, the 1/3 of original volume is concentrated under reduced pressure on Rotary Evaporators, room temperature is cooling
Concentrate is centrifuged 5min with 5000r/min afterwards, after discarding contamination precipitation, 95% ethanol solution of 4 times of amounts is slowly added, and
Being stirred continuously is precipitated licorice polysaccharide sufficiently, after standing for 24 hours, is centrifuged 5min again, obtained licorice polysaccharide precipitating, with anhydrous second
It is dry at 60 DEG C after alcohol washs 2 times；
(2) Radix Glycyrrhizae is put into medicinal herb grinder and is crushed, cross 60 meshes, smashed Radix Glycyrrhizae is then added to the 95% of 25 times of amounts
Ethanol solution in, precipitating is washed 1 time with 95% ethanol solution, is weighed by the heating extraction 3h at 60 DEG C of water-bath, cooling, filtering
Multiple extraction once, merges extracting solution twice, and after concentration plus elutriation goes out to precipitate, and obtains licoflavone using filtering, being dried in vacuo
Extract；
(3) soybean lecithin, cholesterol and Tween 80 are mixed according to weight ratio 80:5:1 and is dissolved in chloroform and ether volume ratio for 1:2
Mixed solution in, ultrasound dissolves it sufficiently, wherein soybean lecithin, the weight of cholesterol and Tween 80 mixture and chloroform and
The solid-liquid ratio of ether mixed volume is 455mg:12mL, is slowly added to the diluted concentration of phosphate buffer be 4.17mg/mL
Licorice polysaccharide solution, stable emulsion is ultrasonically formed in ice-water bath, then at 46 DEG C be evaporated under reduced pressure to formed colloidal state, add
Entering phosphate buffer to continue to rotate 10min, is finally placed in ultrasonic cell disrupte machine and handles 16min, intensity 40% opens 2.5s,
Stop 2.5s, 0.45 μm of miillpore filter squeeze filter 23,0.22 μm filtering with microporous membrane 3 times, it is molten to obtain licorice polysaccharide liposome
Liquid；
(4) by the licoflavone of licorice polysaccharide liposome solutions and step (2) preparation prepared in step (3) according to weight ratio 4:
3:100 is added in flour, is stirred and evenly mixed, and then handles 45min at 105 DEG C in air dry oven, and after treatment is naturally cold
But it to room temperature, is stored after being packed using ventilating plastic bag at the place of being protected from light no more than 25 DEG C.
Claims (7)
1. a kind of processing method of health-care flour, which is characterized in that comprising the following specific steps
(1) Radix Glycyrrhizae is put into medicinal herb grinder and is crushed, crossed 60 meshes, then smashed Radix Glycyrrhizae is added in beaker, then plus
Enter the 9-11 times of distilled water measured, the ultrasonic extraction 30-40min at 35 DEG C of water bath condition is filtered, and is added 9-11 times in filter residue and is measured
Distilled water, after repeating ultrasonic extraction 1 time, merge 2 extracting solutions, be concentrated under reduced pressure on Rotary Evaporators, will after room temperature is cooling
Concentrate is centrifuged 5min with 5000r/min, after discarding contamination precipitation, 95% ethanol solution of 4 times of amounts is slowly added, and constantly
Licorice polysaccharide is precipitated sufficiently in stirring, after standing for 24 hours, is centrifuged 5min again, and obtained licorice polysaccharide precipitating is washed with dehydrated alcohol
It is dry at 60 DEG C after washing 2-3 times；
(2) Radix Glycyrrhizae is put into medicinal herb grinder and is crushed, cross 60 meshes, the ethyl alcohol that smashed Radix Glycyrrhizae is then added to 95% is molten
In liquid, precipitating is washed 1 time with 95% ethanol solution, is repeated by the heating extraction 3-5h at 60-70 DEG C of water-bath, cooling, filtering
It extracts primary, merges extracting solution twice, after concentration plus elutriation goes out to precipitate, and obtains licoflavone using filter, vacuum drying and mentions
Take object；
(3) soybean lecithin, cholesterol and Tween 80 are mixed and is dissolved in the mixed solution of chloroform and ether, ultrasound keeps it sufficiently molten
Solution, is slowly added to the licorice polysaccharide solution for being 4.17mg/mL with the diluted concentration of phosphate buffer, the ultrasonic shape in ice-water bath
It at stable emulsion, is then evaporated under reduced pressure at 46 DEG C to colloidal state is formed, phosphate buffer is added and continues to rotate 10min, most
It is placed in ultrasonic cell disrupte machine and handles 16-20min, intensity 40% opens 2.5s, stops 2.5s, squeezes in 0.45 μm of miillpore filter
Filter 23 time, 0.22 μm filtering with microporous membrane 3 times, obtain licorice polysaccharide liposome solutions；
(4) licoflavone of the licorice polysaccharide liposome solutions prepared in step (3) and step (2) preparation is added in flour,
It stirs and evenly mixs, then handles 45-50min at 105 DEG C in air dry oven, after treatment cooled to room temperature uses
It is stored after ventilating plastic bag packaging at the place of being protected from light no more than 25 DEG C.
2. a kind of processing method of health-care flour according to claim 1, which is characterized in that rotation as described in step (1)
Turn to be concentrated under reduced pressure on evaporimeter, wherein the volume being concentrated is the 1/3 of original volume.
3. a kind of processing method of health-care flour according to claim 1, which is characterized in that general described in step (2)
Smashed Radix Glycyrrhizae is added in 95% ethanol solution, measures wherein 95% ethanol solution additive amount is 25-30 times of Radix Glycyrrhizae weight.
4. a kind of processing method of health-care flour according to claim 1, which is characterized in that big described in step (3)
The weight ratio of Fabaceous Lecithin, cholesterol and Tween 80 is 80:5:1.
5. a kind of processing method of health-care flour according to claim 1, which is characterized in that chlorine described in step (3)
Imitative and ether volume ratio is 1:2.
6. a kind of processing method of health-care flour according to claim 1, which is characterized in that big described in step (3)
The weight and chloroform of Fabaceous Lecithin, cholesterol and Tween 80 mixture and the solid-liquid ratio of ether mixed volume are 455mg:12mL.
7. a kind of processing method of health-care flour according to claim 1, which is characterized in that sweet described in step (4)
The weight ratio of grass polysaccharide liposome solutions, licoflavone and flour is 4-6:3-5:100.
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