CN1101856A - Chinese medicine spray for curing burn and scald - Google Patents
Chinese medicine spray for curing burn and scald Download PDFInfo
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- CN1101856A CN1101856A CN 93119409 CN93119409A CN1101856A CN 1101856 A CN1101856 A CN 1101856A CN 93119409 CN93119409 CN 93119409 CN 93119409 A CN93119409 A CN 93119409A CN 1101856 A CN1101856 A CN 1101856A
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Abstract
This Chinese medicinal spray for different levels of great-area burn and scald is prepared with 11 Chinese medicinal components such as catechu, rehmannia root, rhubarb, lucid ligustrum leaf, etc. through extraction with alcohol. By spraying it onto wound, the wound will quickly healed without scar. It features no need of analgesic or anesthetic, no hypersensitivity, and low cost.
Description
The present invention relates to a kind of medicine, specifically a kind of Chinese medicine for the treatment of burn scalds and can spray.
Burn is a kind of common traumatic illness, and the large tracts of land burn will endanger patient's health even life.Burn in therapeutic process wound pain, to infect long-pending dense, tissue necrosis, scar healing etc. be to quite feel a thorny difficult problem in clinical.CN 1072856A, 92112302.7 disclosed burn sprays are to filter and get with skin and flesh, Herba Houttuyniae, Radix Et Rhizoma Rhei, Cortex Phellodendri, Borneolum Syntheticum, Rhizoma Polygoni Cuspidati, Venenum Bufonis, Galla Chinensis etc. in the mixed liquid dipping Chinese scholartree of ethanol and Pulp Citrulli juice.CN 1072595A, 91106861.9 disclosed liquid for curing scald and burn are to be that raw material processes with mannitol or glycerol, boric acid, chitosan.CN 1070569A, the 91109074.6 disclosed smart lixiviating solution with the immersion Fructus Gardeniae that recover from injury soak rice, and same potassium permanganate, Borneolum Syntheticum, Moschus after the rice dried and crushed are mixed and get.The disclosed Wound healing paste of CN 1071839A, 91108217A is processed and is got with the same zinc sulfadiazine in Pericarpium Musae sterilization back, Borneolum Syntheticum.The summary that comrade Song Hongqi delivers " the Chinese medicine recent developments of burn " system introduction 53 doctor positions obtained encouraging success aspect the Chinese traditional treatment burn, the medicine that relates to has 108 kinds, that dosage form has is diffusing, cream, tincture, oil, be coated with wash, six kinds of films etc.The 22nd of " Chinese medicine information " the 2nd phase of nineteen ninety.
At present, domestic clinical main use silver sulfadiazine needs a large amount of gauze soaks, need wrap up medication to large-area burns especially, and workload is big, and ventilative poor, patient is uncomfortable, and easy infection.To other general ointment such as JINGWANHONG RUANGAO, moistening ointment etc., only suitable small size, light degree patient, and patient's pain is unbearably when changing dressings.The burn that Beijing pharmaceutical factory of traditional Chinese medicine produces is to be the aerosol of main component with the Galla Chinensis only, and is easy to use, can alleviate patient's misery, but this medicine points out on description, need follow the doctor's advice when wound surface breakage or eschar burn are used.
The objective of the invention is provides a kind of I degree, light degree, deep of both being applicable to for burn is clinical, is applicable to the medicine of III degree large tracts of land burn again.Good effect in therapeutic process, patient's misery is few.Both can be used for hospital, also can be used for individual family.
The present invention is on the various prescriptions of broad research (proved recipe, secret recipe, prescription etc.) basis, employed 100 Chinese medicine medicines are analyzed, select Chinese prescription for use according to Chinese medicine and pharmacy compatibility theory and clinical experience, use alcohol extraction then, the extract of gained promptly is the sprayable medicinal liquid of controlling of executing.
Described Chinese medicine has following ten simply:
(1) Borneolum Syntheticum, (2) catechu, (3) Radix Angelicae Sinensis, (4) Pseudobulbus Bletillae (Rhizoma Bletillae), (5) Radix Rehmanniae, (6) Cortex Albiziae, (7) Radix Sanguisorbae, (8) Radix Et Rhizoma Rhei, (9) Cortex Phellodendri, (10) Radix Scutellariae, (11) Folium Ligustri Lucidi.
More than ten simply during Chinese prescription, as long as (11) the flavor Folium Ligustri Lucidi is no less than the 40%(percentage by weight, down with), the extract of gained (being medicinal liquid) just has the clinical effectiveness of treatment burn.
For ease of control of quality in the industrial processes, unified specification should be defined as the consumption of each flavor, and each flavor can be in following ratio prescription:
(1) Borneolum Syntheticum: 0.5~1.0%
(2) catechu: 1.0~5.0%
(3) Radix Angelicae Sinensis: 1.0~5.0%
(4) Pseudobulbus Bletillae (Rhizoma Bletillae): 1.0~5.0%
(5) Radix Rehmanniae: 1.0~5.0%
(6) Cortex Albiziae: 3.0~10.0%
(7) Radix Sanguisorbae: 3.0~10.0%
(8) Radix Et Rhizoma Rhei: 5.0~15.0%
(9) Cortex Phellodendri: 5.0~15.0%
(10) Radix Scutellariae: 5.0~15.0%
(11) Folium Ligustri Lucidi: 40~60%
In brief, each 5~15%, (11) flavor 40~60% of each 3~10%, the (8) to (10) three flavor of each 1~5%, (6), (7) two flavor of (1) flavor 0.5~1%, the (2) to (5) four flavors.
Broken slightly pure behind each prescription of distinguishing the flavor of, more carefully help extraction certainly, be unfavorable for filtering but cross detailed rules and regulations.Ethanol with 95% or aquiferous ethanol extraction.Extract available traditional infusion method, this method helps energy savings, but long taking more than seven days of time also can only need to reflux about 4 hours in the backflow of distillating still internal heating.Extraction finishes after-filtration, ethanol with 95% or aquiferous ethanol washing filtering residue, and resulting filtrate promptly is to can be used for clinical medicinal liquid.
As making solvent with 95% ethanol, though it is clinical that gained filtrate can be directly used in, but because concentration of alcohol height, wound surface zest to breakage is big, the patient has violent pain, so should add distilled water in filtrate, the control concentration of alcohol is about 40-60%, the medicinal liquid that makes so just directly in the fill spray bottle for clinical use.
Raw material of the present invention is easy to get, technology is simple, pollution-free, cheap, both be applicable to hospital, be applicable to family again, but main advantage is the following aspects that clinical course embodies:
1, anti-infectious function: do not have bacterial growth behind the wound surface spray medicine, laboratory test has tangible killing action to staphylococcus and bacillus pyocyaneus etc.
2, wound surface becomes the crust situation: II-III degree wound surface spray medicine is promptly formed thin film after 24~48 hours, after 3~5 days crust, generally spray medicine and can discontinue medication in 5~7 days.The crust softness has elasticity preferably, and electron microscopic observation has micropore on the crust, thereby good permeability, and no detritus oozes out under the crust, can protect wound surface preferably.
3, wound healing situation:
Light degree: medication 5~7 days, wound healing, crust came off automatically in 10~15 days, no cicatrix.
Dark II degree: medication 7 days, wound healing, 15~20 days decrustation.
III degree wound surface generally needs repeatedly surgery skin grafting.Early stage state of an illness shakiness should not be performed the operation, and is poor because of the too early molten crust surgical effect of wound surface again when stable disease, produces sepsis or septicemia sometimes.And use the present invention, the soft crust that wound surface forms on the one hand can infection, can protect wound surface insoluble crust for three weeks on the other hand, and this has just won the time for operation.There are three routine patients all to cut the crust skin grafting later on, all succeed at 20 days.
4, to the reaction of pain: when spraying medicine for the first time, have one to cross property acupuncture pain, continue 20 seconds, but all need not with analgesic or anesthetis, spray medicine 4~5 times later on again spray promptly do not have sense of discomfort, and the pain that itself causes of burning is had mitigation.
5, body reaction after the medication: body temperature generally below 38.5 degree, does not have irritated reaction after the medication, and patient liver, renal function are normal.
The embodiment of the invention:
With total amount 1000 grams is the example prescription:
1, get (1) flavor Borneolum Syntheticum 5 grams, (2) to (5) four taste tea, Radix Angelicae Sinensis, the Pseudobulbus Bletillae (Rhizoma Bletillae), each 50 gram of the Radix Rehmanniae, (6), (7) two flavor Cortex Albiziaes, each 30 gram of Radix Sanguisorbae, (8) to (10) three flavor Radix Et Rhizoma Rhei, Cortex Phellodendri, each 100 gram of Radix Scutellariae, (11) the flavor Folium Ligustri Lucidi 435 grams, broken slightly back mix homogeneously, place retort, soaked 10 days with the 2000 gram sealings of 95% ethanol, filter then, with distilled water wash filtering residue 2~3 times, obtain the pale brown color medicinal liquid of about 3000~4500ml (the medicinal liquid alcohol content is about 40~60%), can clinical use in the gas blowout bottle of packing into.
2, get (1) flavor 10 grams, each 50 gram of (2) to (5) four flavor, each 100 gram of (6), (7) two flavors, each 50 gram of (8) to (10) three flavor, (11) flavor 440 grams, operation is with embodiment 1.
3, get (1) flavor 10 grams, each 10 gram of (2) to (5) four flavor, each 50 gram of (6), (7) two flavors, each 150 gram of (8) to (10) three flavor, (11) flavor 400 grams, the soak with ethanol with 70%, other are operated with embodiment 1.
4, get (1) flavor 5 grams, each 25 gram of (2) to (5) four flavor, each 50 gram of (6), (7) two flavors, each 100 gram of (8) to (10) three flavor, (11) flavor 495 grams, the soak with ethanol with 75%, other are operated with embodiment 1.
5, get (1) flavor 7 grams, each 12 gram of (2) to (5) four flavor, each 40 gram of (6), (7) two flavors, each 100 gram of (8) to (10) three flavor, (11) flavor 565 grams, restrain in the 5000ml distilling flask with 95% ethanol 2000 and to reflux four hours, cooled and filtered, later operation is with embodiment 1.
6, get (1) flavor 6 grams, each 15 gram of (2) to (5) four flavor, each 80 gram of (6), (7) two flavors, each 120 gram of (8) to (10) three flavor, (11) flavor 414 grams, other are operated with embodiment 5.
7, get (1) flavor 5 grams, each 20 gram of (2) to (5) four flavor, each 50 gram of (6), (7) two flavors, each 80 gram of (8) to (10) three flavor, (11) flavor 575 grams, the alcohol extraction with 75%, operation is with embodiment 5.
8, get (1) flavor 10 grams, each 25 gram of (2) to (5) four flavor, each 70 gram of (6), (7) two flavors, each 50 gram of (8) to (10) three flavor, (11) flavor 600 grams, the alcohol extraction with 70%, operation is with embodiment 5.
The present invention is used for when clinical, the person of being admitted to hospital is adopted the complete directly sprinkling that exposes through the debridement of routine, sterilization back, sprayed once in per 2 hours during beginning, be kept to every day 4~5 times after 24~48 hours film forming, continue 3~5 days films of spray medicine and promptly become gentle crust of cooking a meal, can discontinue medication or intermittent use.
Claims (2)
1, a kind of Chinese medicine for the treatment of burn scalds and can spray, and with medicinal 95% ethanol or aquiferous ethanol extraction in behind the prescription and get, it is characterized in that:
A, described prescription by following ten simply Chinese medicine form:
(1) Borneolum Syntheticum, (2) catechu, (3) Radix Angelicae Sinensis, (4) Pseudobulbus Bletillae (Rhizoma Bletillae), (5) Radix Rehmanniae, (6) Cortex Albiziae, (7) Radix Sanguisorbae, (8) Radix Et Rhizoma Rhei, (9) Cortex Phellodendri, (10) Radix Scutellariae, (11) Folium Ligustri Lucidi;
(11) the flavor Folium Ligustri Lucidi is no less than 40% when B, prescription.
2, a kind of Chinese medicine for the treatment of burn according to claim 1 scalds and can spray, it is characterized in that: ten simply Chinese medicine in following ratio prescription: (1) flavor 0.5~1%, (2) to (5) four the flavor each 1~5%, (6), (7) two the flavor each 3~10%, each 5~15%, the (11) flavor 40~60% of (8) to (10) three flavor.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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CN 93119409 CN1101856A (en) | 1993-10-20 | 1993-10-20 | Chinese medicine spray for curing burn and scald |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
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CN 93119409 CN1101856A (en) | 1993-10-20 | 1993-10-20 | Chinese medicine spray for curing burn and scald |
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CN1101856A true CN1101856A (en) | 1995-04-26 |
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CN 93119409 Pending CN1101856A (en) | 1993-10-20 | 1993-10-20 | Chinese medicine spray for curing burn and scald |
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Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101912532A (en) * | 2010-08-30 | 2010-12-15 | 张树仁 | External traditional Chinese medicine preparation for treating burns, scalds and frostbite |
CN102727638A (en) * | 2012-06-18 | 2012-10-17 | 邝桂发 | Medicine used for treating burn and scald |
US8535735B2 (en) | 2002-03-01 | 2013-09-17 | Unigen, Inc. | Identification of free-B-ring flavonoids as potent COX-2 inhibitors |
US8568799B2 (en) | 2002-03-22 | 2013-10-29 | Unigen, Inc. | Isolation of a dual COX-2 and 5-lipoxygenase inhibitor from acacia |
US8652535B2 (en) | 2002-04-30 | 2014-02-18 | Unigen, Inc. | Formulation of a mixture of free-B-ring flavonoids and flavans for use in the prevention and treatment of cognitive decline and age-related memory impairments |
US8771761B2 (en) | 2006-10-12 | 2014-07-08 | Unigen, Inc. | Composition for treating atopic dermatitis comprising extracts of bamboo and scutellaria |
US9370544B2 (en) | 2002-04-30 | 2016-06-21 | Unigen, Inc. | Formulation of a mixture of free-B-ring flavonoids and flavans as a therapeutic agent |
US9622964B2 (en) | 2003-04-04 | 2017-04-18 | Unigen, Inc. | Formulation of dual cycloxygenase (COX) and lipoxygenase (LOX) inhibitors for mammal skin care |
-
1993
- 1993-10-20 CN CN 93119409 patent/CN1101856A/en active Pending
Cited By (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8535735B2 (en) | 2002-03-01 | 2013-09-17 | Unigen, Inc. | Identification of free-B-ring flavonoids as potent COX-2 inhibitors |
US9061039B2 (en) | 2002-03-01 | 2015-06-23 | Unigen, Inc. | Identification of Free-B-Ring flavonoids as potent COX-2 inhibitors |
US8568799B2 (en) | 2002-03-22 | 2013-10-29 | Unigen, Inc. | Isolation of a dual COX-2 and 5-lipoxygenase inhibitor from acacia |
US9168242B2 (en) | 2002-03-22 | 2015-10-27 | Unigen, Inc. | Isolation of a dual COX-2 and 5-lipdxygenase inhibitor from Acacia |
US8652535B2 (en) | 2002-04-30 | 2014-02-18 | Unigen, Inc. | Formulation of a mixture of free-B-ring flavonoids and flavans for use in the prevention and treatment of cognitive decline and age-related memory impairments |
US9370544B2 (en) | 2002-04-30 | 2016-06-21 | Unigen, Inc. | Formulation of a mixture of free-B-ring flavonoids and flavans as a therapeutic agent |
US9655940B2 (en) * | 2002-04-30 | 2017-05-23 | Unigen, Inc. | Formulation of a mixture of free-B-ring flavonoids and flavans as a therapeutic agent |
US9849152B2 (en) | 2002-04-30 | 2017-12-26 | Unigen, Inc. | Formulation of a mixture of Free-B-ring flavonoids and flavans as a therapeutic agent |
US9622964B2 (en) | 2003-04-04 | 2017-04-18 | Unigen, Inc. | Formulation of dual cycloxygenase (COX) and lipoxygenase (LOX) inhibitors for mammal skin care |
US8771761B2 (en) | 2006-10-12 | 2014-07-08 | Unigen, Inc. | Composition for treating atopic dermatitis comprising extracts of bamboo and scutellaria |
US9623068B2 (en) | 2006-10-12 | 2017-04-18 | Unigen, Inc. | Composition for treating atopic dermatitis comprising extracts of bamboo and scutellaria |
CN101912532A (en) * | 2010-08-30 | 2010-12-15 | 张树仁 | External traditional Chinese medicine preparation for treating burns, scalds and frostbite |
CN102727638A (en) * | 2012-06-18 | 2012-10-17 | 邝桂发 | Medicine used for treating burn and scald |
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