CN110075016A - Skin-whitening composition containing thick leaf Schisandra chinens P.E - Google Patents
Skin-whitening composition containing thick leaf Schisandra chinens P.E Download PDFInfo
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- CN110075016A CN110075016A CN201910263225.9A CN201910263225A CN110075016A CN 110075016 A CN110075016 A CN 110075016A CN 201910263225 A CN201910263225 A CN 201910263225A CN 110075016 A CN110075016 A CN 110075016A
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- skin
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- leaf schisandra
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/79—Schisandraceae (Schisandra family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/005—Preparations for sensitive skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
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- Dermatology (AREA)
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- Alternative & Traditional Medicine (AREA)
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Abstract
The invention discloses contain skin-whitening composition of the thick leaf Schisandra chinens P.E as effective component.
Description
Technical field
The present invention relates to the skin-whitening compositions containing thick leaf Schisandra chinens P.E.
Background technique
The colour of skin of people is determined by many factors, such as generates the work of the melanocyte (melanocyte) of melanin pigment
Property, vascular distribution, skin thickness or whether containing just like the pigment that can be exemplified as carotenoid and bilirubin etc..Wherein, pass through
It can be exemplified as the effect of a variety of enzymes of tyrosinase, generate the formation degree of the black pigment melanin in melanocyte,
It is one of the most important factor for determining the colour of skin.
Although melanin present in skin protects the important function of human body under playing the ultraviolet light the effects of, excessive
In the presence of, it is known that its can not only cause as freckle, color spot, mole, senile plaque Skin pigmentation, also act as promotion
Skin aging, induce cutaneum carcinoma factor effect.
In order to treat or mitigate melanin excessively generate caused by Skin pigmentation, although used can be exemplified as it is anti-bad
Hematic acid, kojic acid, arbutin, quinhydrones or their derivative known performance skin whitening effects many kinds of substance, but they are not
Perfect skin whitening effects can be shown, and skin irritatin is strong, use is restricted.
Summary of the invention
Technical problems to be solved
The purpose of the present invention is to provide a kind of compositions with brilliant skin whitening effects.In addition, the purpose of the present invention
It is to provide a kind of cosmetic composition with brilliant skin whitening effects.
Technical solution
The present invention provides the skin-whitening composition for containing thick leaf Schisandra chinens P.E as effective component from an angle.
The present invention provides the skin-whitening use for containing thick leaf Schisandra chinens P.E as effective component from another angle
Cosmetic composition.
Beneficial effect
Composition in the present invention contains thick leaf Schisandra chinens P.E as effective component, can pass through inhibition melanin production performance
Brilliant skin whitening effects out, small to the irritation of skin, sensitive skin person also can freely use.
Detailed description of the invention
Fig. 1 show the chart for illustrating the melanin production rejection ability of thick leaf Schisandra chinens P.E.
Specific embodiment
In description of the invention signified " skin ", it is meant that the tissue of covering animal body surface, being not only includes covering surface
The tissue of the body surfaces such as portion or body further includes the concept of the broad sense of scalp and hair.In addition, in description of the invention, " sensibility
Skin " may be defined as it is low to the repellence of outside stimulus, be easy by outside stimulus cause as shouting pain, red heat, scorching hot, itch,
It is special that the reason of skin of flush, drying, inflammation etc. abnormal response, above-mentioned sensitive, can be enumerated as geneogenous skin
The misuse of property, family history, medical history, cosmetics etc. and abuse, living environment or pressure etc..
" extract ", will no matter being extracting method, Extraction solvent, extract component or extract form in description of the invention
By the concept for extracting the broad sense that the substance that natural goods ingredient obtains is included entirely within.
The present invention provides the skin-whitening group for containing thick leaf Schisandra chinens P.E as effective component from an angle
Close object.Thick leaf Schisandra chinens P.E is able to suppress melanin production, therefore can have outstanding skin containing its composition
Whitening effect.Specifically, the composition based on an angle of the invention has by containing thick leaf Schisandra chinens P.E conduct
Ingredient is imitated, the brightness and uniformity of the whole colour of skin can be improved, be able to suppress pigment over-deposit.In addition, thick leaf Schisandra chinensis is extracted
Object is shown to skin almost non-stimulated low irritant, even therefore include its composition sensitive skin person also can from
By using.It can be seen that having the shortcomings that the outstanding of the i.e. high skin irritation of one of Traditional skin whitening material can be improved
Effect.
The thick leaf Schisandra chinensis (Kadsura coccinea (Lem.) A.C.Smith) of an angle according to the present invention is sometimes
Also known as " black tiger ".An angle according to the present invention, thick leaf Schisandra chinens P.E include but is not limited to thick leaf Schisandra chinensis
Leaf, stem, root, flower, fruits and seeds extract.Another angle according to the present invention, thick leaf Schisandra chinens P.E include with
One of selection is above in group composed by the mixture of water, organic solvent and water and organic solvent mentions thick leaf Schisandra chinensis
Extract is obtained, specifically, including hot water extract or the alcohol extracting thing of thick leaf Schisandra chinensis of thick leaf Schisandra chinensis.Described
Organic solvent includes but is not limited to alcohol, acetone, hexane, ether, ethyl acetate, diethyl ether, group composed by methyl ethyl ketone and chloroform
It is more than one of middle selection.The alcohol includes C1~C5 lower alcohol, C1~C5 lower alcohol include but is not limited to methanol, ethyl alcohol,
In group composed by isopropanol, normal propyl alcohol, n-butanol and isobutanol more than one of selection.
The composition of an angle according to the present invention, the total weight based on composition can contain 0.001 to 80 weight
Measure %, specially 0.01 to 50 weight %, the more specifically thick leaf Schisandra chinens P.E of 0.1 to 10 weight %.Comprising described
Weight % in the case where, be not only suitable for skin whitening effects required for showing the present invention, and can meet simultaneously
The stability and safety of composition are also suitable comprising the range from the point of view of cost performance.
The present invention provides the cosmetic composition for containing thick leaf Schisandra chinens P.E as effective component from an angle.
The cosmetic composition can show skin whitening effects, specifically, can improve or prevent freckle, color spot, mole,
The Skin pigmentation of senile plaque and other such as skin blemishes.Especially the cosmetic composition is reduced to skin
Irritation, therefore can not be limited by the skin type of user and carry out using skin type described in including sensibility skin
Skin or dry skin.
Cosmetic composition in the present invention may be provided as the whole dosage forms for being suitble to local use.For example, can be provided that
The emulsion obtained in oily phase of emulsion, Aqueous dispersions obtained in water phase is mutually dispersed in for solution, oil, suspension, solid, is coagulated
The dosage form of glue, powder, paste, foam (foam) or aerosol composition.The composition of above-mentioned dosage form can pass through corresponding field
Commonsense method is prepared.
Cosmetic composition in the present invention in addition to the materials noted above, in the range of not influencing main effect, with comprising
The other ingredients for playing castering action to main effect are preferred.Specifically, may include the cosmetics group being able to ascend in the present invention
Close kojic acid, arbutin or the ascorbic acid derivates of the skin whitening effects of object.In addition, the cosmetic composition in the present invention is also
It may include moisturizer, softening agent, surfactant, ultraviolet absorbing agent, preservative, fungicide, antioxidant, pH adjusting
Agent, organic and inorganic pigment, fragrance, freshener or antiperspirant.The use level of the ingredient is not influencing the purpose of the present invention
And in the range of effect, 0.01 can be can be on the basis of composition total weight by technical staff's unrestricted choice, use level
To 5 weight %, 0.01 to 3 weight % specifically can be.
The present invention provides the pharmaceutical compositions for containing thick leaf Schisandra chinens P.E as effective component from an angle.Institute
The pharmaceutical compositions stated can show skin whitening effects, specifically, can improve or treat such as freckle, color spot, mole, old
Year spot and other Skin pigmentations such as skin blemishes.
Based on the pharmaceutical compositions of an angle of the invention, can be administered orally, rectally, local administration, warp
The modes such as skin administration, intravenous injection, intramuscular injection, intraperitoneal injection, subcutaneous injection are administered.
Dosage form for oral administration can be but not limited to tablet, pill, soft capsule and hard capsule, granule, powder,
Fine granule, liquor, suspension or globule.These dosage forms in addition to effective component can also comprising diluent (such as: lactose, Portugal
Grape sugar, sucrose, mannitol, sorbierite, cellulose or glycine), lubricant (such as: silica, talcum, stearic acid or poly- second two
Alcohol) or adhesive (such as: aluminium-magnesium silicate, gelatinized corn starch, gelatin, tragacanth, methylcellulose, sodium carboxymethylcellulose or poly- second
Alkene pyrrolones).It can according to circumstances include the pharmacies additives such as disintegrating agent, absorbent, colorant, flavouring agent or sweetener.
Preparation for non-oral administration can be but not limited to injection, drops, lotion, ointment, gel, creme, mix
Suspension, emulsion, suppository, patch or spray.
The effective component of pharmaceutical compositions based on an angle of the invention, may age according to administration object, property
Not, weight, pathological state and its severity, administration route or according to the judgement of prescriber and it is different.Based on the above-mentioned factor
The determination of usage amount, in the level of technical staff, being administered daily dosage can be but not limited to, and be exemplified as 0.1mg/kg/
Day was to 100mg/kg/, more specifically 5mg/kg/ to 50mg/kg/.
The present invention provides the food compositions for containing thick leaf Schisandra chinens P.E as effective component from an angle.Institute
The food compositions stated include hobby food compositions or health food composition.Another angle according to the present invention contains
Thick leaf Schisandra chinens P.E can show skin whitening effects as the food compositions of effective component, specifically, can
Improve or prevent the Skin pigmentation such as freckle, color spot, mole, senile plaque and other such as skin blemishes.
The dosage form of the food compositions is not particularly limited, can be made into as tablet, granule, pulvis, such as beverage
The dosage forms such as liquid, caramel candy, gel, stick.In addition to effective component, technical staff is not difficult to select the food compositions of various dosage forms
It selects suitable dosage form or is cooperated according to the ingredient for using purpose to select the field usually used, made simultaneously with other raw materials
In the case where, it can cause to promote effect.
The determination of the dosage of the effective component, in the level of technical staff, the usage amount based on the above-mentioned factor
Determination, in the level of technical staff, being administered daily dosage can be but not limited to, and be exemplified as 0.1mg/kg/ days extremely
It 5000mg/kg/ days, more specifically 50mg/kg/ to 500mg/kg/, can be according to the age of administration object, health status, simultaneously
Send out many factors such as disease and different.
It is exemplified below embodiment and experimental example, composition and effect of the invention are specifically described.However, providing these
Embodiment and experimental example are intended to help to understand the present invention, and scope of the invention and range are not limited by it.
The preparation of [embodiment] thickness leaf Schisandra chinens P.E
Thick leaf Schisandra chinens P.E is prepared by commonly used approach in the industry using thick leaf Schisandra chinensis.Specifically, to thick leaf
Schisandra chinensis 1kg is cleaned, and is shredded after 24 hours dry at 60 DEG C.It is small that about 1 is extracted at 70 to 75 DEG C using 95% ethyl alcohol
When, it repeats to extract 3 times.It filters later, obtains thick leaf Schisandra chinens P.E 113g.
The evaluation of [experimental example 1] melanin production inhibitory effect
The melanin production inhibitory effect for evaluating thick leaf Schisandra chinens P.E, using the thick leaf Schisandra chinens P.E in embodiment into
The following experiment of row.
Mouse melanin cell (Murine melanoma) (Melan-a) is inoculated into the RPMI640 containing FBS first
Or in same above bathmic culture medium, with every well 1 × 105It is a to be seeded on 12-well culture plate, later
In 5%CO2, cultivated under the conditions of 37 DEG C, until cell fusion (confluent) is to the bottom well about 80%.It is gone after culture
Except culture medium, the arbutin for diluting the thick leaf Schisandra chinens P.E and 0.5,1 and 2mM that there are 1,5 and 10 μ g/ml respectively is replaced with
Culture medium, later in 5%CO2, cultivate 7 at 37 DEG C.The concentration range of the sample is determined by toxicity test.It eliminates
The cell of culture medium is cleaned using PBS, is handled later using trypsase, and cell is recycled.Recycle obtained cell
With 5,000~10,000rpm centrifugal treating 10 minutes, supernatant is removed, agglomerate (pellet) is obtained.Obtained cell mass exists
It is dry at 60 DEG C, 1M NaOH 100 μ l or cell lysis buffer solution (cell lysis containing 10%DMSO are added later
Buffer), intracellular melanin is obtained in 60 DEG C of thermostats.Microplate reader (microplate reader) is utilized at 490nm
Collection liquid is measured, the amount of protein is found out using coomassie brilliant blue, finds out the melanin in a certain number of cells later
The amount of amount or the melanin in a certain number of protein.
Compare the thick leaf Schisandra chinensis of each concentration of the control group of untreated samples and the melanin production activity of arbutin
(%) is as shown in following table and Fig. 1.
[table 1]
As mentioned the results show that thick leaf Schisandra chinens P.E has melanin production inhibitory effect, effect is better than traditional
It is known as the arbutin of skin-whitening substance.By the above results it is found that the composition energy containing thick leaf Schisandra chinens P.E
Enough inhibit melanin production, there are outstanding skin whitening effects.
[experimental example 2] skin irritatin degree evaluation
The skin irritatin degree for evaluating thick leaf Schisandra chinens P.E, with traditional kojic acid for being known as skin-whitening substance
(kojic acid) is compared, and is tested as follows.
It selects to generation shouting pain, fervid sensitive subject 15 is stimulated, by kojic acid (purchased from YM chemistry) and in fact
It applies thick each 0.5ml of leaf Schisandra chinens P.E in example and is coated in face left and right at random, with 3.0 points be full according to shouting pain and fervid degree
Point, 0.1 point evaluated for unit.Evaluation criterion and evaluation result are as follows.
[table 2]
| Kojic acid | Thick leaf Schisandra chinens P.E | |
| Shouting pain | 0.85 | 0.35 |
| It is fervid | 0.50 | 0.55 |
| It is average | 0.68 | 0.45 |
0~0.4: completely or nearly imperceptible stimulation
0.5~1.0: feeling faint stimulation
1.1~2.0: feeling the stimulation of O-level
2.1~3.0: feeling serious stimulation
Shown in result as mentioned, the position for being coated with kojic acid can feel shouting pain and red heat, be coated with thick leaf Schisandra chinensis on the contrary and mention
The position of object is taken to hardly feel shouting pain and red heat.That is, thick leaf Schisandra chinens P.E and existing known skin-whitening substance
Kojic acid is different, is nearly free from stimulation to skin, thus be also free in sensitive using.
Combination dosage form example based on an angle of the invention is described as follows, it can also be used in other a variety of doses
Type, and the present invention is not limited.
[dosage form example 1] lotion
The composition recorded in following table prepares lotion according to usual way.
[table 3]
[dosage form example 2] creme
The composition recorded in following table prepares creme according to usual way.
[table 4]
| Ingredient | Content (weight %) |
| Thick leaf Schisandra chinens P.E | 1.0 |
| Polyethylene glycol stearate | 2.0 |
| Glycerin monostearate | 5.0 |
| Cetanol | 4.0 |
| Squalene | 3.0 |
| 2 ethyl hexanoic acid glyceryl ester | 6.0 |
| Glycosyl sphingolipid | 1.0 |
| 1,3 butylene glycol | 7.0 |
| Purified water | Surplus |
[dosage form example 3] soft capsule
By thick leaf Schisandra chinens P.E 100mg, extract of soybean 50mg, soybean oil 180mg, red ginseng extract 50mg, palm oil
2mg, palm fixed oil 8mg, yellow wax 4mg and lecithin 6mg mixing, prepare soft capsule according to usual way.
[dosage form example 4] tablet
By thick leaf Schisandra chinens P.E 100mg, extract of soybean 50mg, glucose 100mg, red ginseng extract 50mg, starch
96mg and magnesium stearate 4mg mixing, after addition ethyl alcohol forms particle, dry tabletting forms tablet.
[dosage form example 5] healthy beverage
Thick leaf Schisandra chinens P.E ... ... ... ..1000 ㎎
1000 ㎎ of citric acid ... ... ... ... ...
Oligosaccharides ... ... ... ... ... ..100g
Taurine ... ... ... ... ... 1g
Purified water ... ... ... ... ... surplus
Mentioned component is mixed according to common healthy beverage preparation method, later agitating and heating about 1 hour at about 85 DEG C, it
Afterwards by filter sterilizing solution obtained.
Claims (7)
1. purposes of the thick leaf Schisandra chinens P.E in preparation composition for whitening skin.
2. purposes according to claim 1, which is characterized in that the thickness leaf Schisandra chinens P.E accounts for the composition weight
0.001wt% to 80wt%.
3. purposes according to claim 1, which is characterized in that the thickness leaf Schisandra chinens P.E is the C1 of thick leaf Schisandra chinensis
To the rudimentary alcohol extracting thing of C5.
4. purposes according to claim 1, which is characterized in that the composition inhibition generates black in Skin Cell
Element.
5. according to claim 1 to the purposes described in any one of claim 4, which is characterized in that the composition is makeup
Product composition.
6. purposes according to claim 5, which is characterized in that the composition is used for sensitive.
7. purposes according to claim 6, which is characterized in that the composition is used for the skin sensitive to kojic acid.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910263225.9A CN110075016A (en) | 2011-11-29 | 2011-11-29 | Skin-whitening composition containing thick leaf Schisandra chinens P.E |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910263225.9A CN110075016A (en) | 2011-11-29 | 2011-11-29 | Skin-whitening composition containing thick leaf Schisandra chinens P.E |
| CN2011103864539A CN103126945A (en) | 2011-11-29 | 2011-11-29 | Skin whitening composition containing thick-leaf Chinese magnolivine fruit extract powder |
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| Application Number | Title | Priority Date | Filing Date |
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| CN2011103864539A Division CN103126945A (en) | 2011-11-29 | 2011-11-29 | Skin whitening composition containing thick-leaf Chinese magnolivine fruit extract powder |
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| CN110075016A true CN110075016A (en) | 2019-08-02 |
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| CN201910263225.9A Pending CN110075016A (en) | 2011-11-29 | 2011-11-29 | Skin-whitening composition containing thick leaf Schisandra chinens P.E |
| CN2011103864539A Pending CN103126945A (en) | 2011-11-29 | 2011-11-29 | Skin whitening composition containing thick-leaf Chinese magnolivine fruit extract powder |
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| KR (1) | KR101957847B1 (en) |
| CN (2) | CN110075016A (en) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103860436B (en) * | 2014-03-06 | 2017-01-11 | 集安五味堂生物科技有限公司 | Cosmetic composition containing schisandra chinensis extract and nourishing whitening cream |
| CN103830152B (en) * | 2014-03-14 | 2015-10-28 | 集安五味堂生物科技有限公司 | There is cosmetic composition and the essence of whitening function |
| CN107049852A (en) * | 2017-02-16 | 2017-08-18 | 广东华夏友美生物科技有限公司 | A kind of cosmetics of whitening spot-removing are prepared and its applied |
| CN111603518B (en) * | 2020-06-28 | 2021-12-31 | 中南林业科技大学 | Application of black tiger extract and macleaya cordata extract in preparation of whitening or blood sugar reducing medicines |
| CN111568836A (en) * | 2020-07-08 | 2020-08-25 | 贵州省山地资源研究所 | Application of fructus Cannabis in preparing whitening skin care product and its preparation method |
| CN114042020A (en) * | 2021-10-09 | 2022-02-15 | 湖南医药学院 | Black tiger mask essence and preparation method and application thereof |
| KR102426674B1 (en) | 2021-10-14 | 2022-07-29 | 최용학 | Kadsura coccinea liquid tea and Manufacturing method thereof |
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| CN1104088A (en) * | 1994-09-02 | 1995-06-28 | 符少聪 | Freckle-eliminating medicine |
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| US5747006A (en) * | 1997-05-14 | 1998-05-05 | Amway Corporation | Skin whitener composition containing acerola cherry fermentate |
| US5980904A (en) * | 1998-11-18 | 1999-11-09 | Amway Corporation | Skin whitening composition containing bearberry extract and a reducing agent |
| JP2004244326A (en) * | 2003-02-12 | 2004-09-02 | Ichimaru Pharcos Co Ltd | Bleaching agent and bleaching cosmetic |
| KR100531686B1 (en) | 2003-04-29 | 2005-11-28 | 학교법인 영남학원 | Cosmetic composition comprising the extract of Machilus Thunbergii for skin whitening |
| KR20100042086A (en) * | 2008-10-15 | 2010-04-23 | 인하대학교 산학협력단 | Composition for whitening containing extract of cortex cinnamomi cassiae |
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-
2012
- 2012-11-26 KR KR1020120134179A patent/KR101957847B1/en active IP Right Grant
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| Publication number | Publication date |
|---|---|
| CN103126945A (en) | 2013-06-05 |
| KR101957847B1 (en) | 2019-03-15 |
| KR20130060130A (en) | 2013-06-07 |
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