CN110037257A - A kind of formula and preparation method of immunological regulation and enhancing physical strength - Google Patents
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- CN110037257A CN110037257A CN201910252557.7A CN201910252557A CN110037257A CN 110037257 A CN110037257 A CN 110037257A CN 201910252557 A CN201910252557 A CN 201910252557A CN 110037257 A CN110037257 A CN 110037257A
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Abstract
It include following weight raw material: bovine colostrum 0.5-5g, avenabeta glucosan 0.5-5g, albumin Gly-His-Lys 0.5-5g, Acerola cherry fruit powder 0.01-0.5g, chitosan oligosaccharide 0.01-0.3g, nutrient yeast powder 0.001-0.01g, bird's nest Gly-His-Lys 0.001-0.01g, haematococcus pluvialis powder 0.001-0.01g, broccoli seed water extract 0.01-0.3g, Guarana extract 0.01-0.5g in every bag of 5g formula the invention discloses the formula and preparation method of a kind of immunological regulation and enhancing physical strength.The present invention is using several pure natural animals and plants as raw material, through reasonable compatibility, scientific matching forms, long-term consumption product of the present invention adjustable intestinal flora strengthen immunity, improves body energy, builds up health, eliminates fatigue, delays senescence, beautifying face and moistering lotion, and without side-effects, the wide application of the crowd of safety.
Description
Technical field
The present invention relates to food technology field, in particular to a kind of immunological regulation and formula and the preparation side for enhancing physical strength
Method.
Background technique
Modern medical science discovery, being immunized is the factor for having substantial connection with aging, and immunocyte decline is aging
One of most important reason.Some special cells of body immune system can will invade intracorporal bacterium, virus and decline in vivo
Old dead cell, the cell being mutated and the substance for causing allergy, are wholly swallowed and are eliminated, to maintain
The stabilization of vivo environment keeps body health.But body's immunity began to decline at 30 years old or so, and this variation is quiet
So, slowly, be continued for.In addition, the allegro life style of modern, overworked to also result under autoimmunity
Drop.
The body of hypoimmunity is easy to infected or cancer stricken；Immunity is extraordinary also to generate insalubrious knot
Fruit, such as cause allergic reaction, autoimmune disease.A variety of causes prevents immune system from normally playing protective effect, herein
In the case of, easily incur the infection such as bacterium, virus, fungi, therefore it is exactly liable to illness that hypoimmunity, which most directly shows,.Cause
Frequent illness has aggravated the consumption of body, so generally having a delicate constitution, malnutritive, apathetic, fatigue and weak, appetite
The performance such as reduction, sleep disturbance, it is sick, having an injection to take medicine has become homely food.It is sick every time to be lot more time to restore,
And usually recurrent exerbation.It if things go on like this will lead to physical and intellectual depauperation, also easily induce major disease.
Bright according to one global sex inventory of the World Health Organization, the people of global true health only accounts for 5%, diagnoses ill people
Also 20% is only accounted for, 75% people is in sub-health state, especially white collar and the middle-aged and the old, and inferior health proportion is higher.
Hypoimmunity, sleep disturbance are the most important forms of expression of inferior health, serious to reduce people's lives quality, therefore develop one
The healthy food of kind strengthen immunity has huge market prospects.
Summary of the invention
In view of the deficiencies of the prior art, the purpose of the present invention is to provide a kind of immunological regulation and enhancing physical strength formula,
Adjustable intestinal flora strengthen immunity, improves body energy, builds up health, eliminates fatigue, delays senescence, beautifying face and moistering lotion,
And without side-effects, the wide application of the crowd of safety.
In order to achieve the above object, the technical solution of the present invention is as follows:
The formula of a kind of immunological regulation and enhancing physical strength includes following weight raw material: bovine colostrum in every bag of 5g formula
0.5-5g, avenabeta glucosan 0.5-5g, albumin Gly-His-Lys 0.5-5g, Acerola cherry fruit powder 0.01-0.5g, chitosan oligosaccharide 0.01-
0.3g, nutrient yeast powder 0.001-0.01g, bird's nest Gly-His-Lys 0.001-0.01g, haematococcus pluvialis powder 0.001-0.01g, broccoli
Seed water extract 0.01-0.3g, Guarana extract 0.01-0.5g.
It preferably, include following weight raw material in every bag of 5g formula: bovine colostrum 1-5g, avenabeta glucosan 1-5g, white
Protein peptide powder 1-5g, Acerola cherry fruit powder 0.05-0.5g, chitosan oligosaccharide 0.05-0.3g, nutrient yeast powder 0.005-0.01g, bird's nest
Gly-His-Lys 0.005-0.01g, haematococcus pluvialis powder 0.005-0.01g, broccoli seed water extract 0.1-0.3g, Guarana extract
0.05-0.5g。
It preferably, include following weight raw material: bovine colostrum 2g, avenabeta glucosan 1.5g, white egg in every bag of 5g formula
The raw red ball of white Gly-His-Lys 1g, Acerola cherry fruit powder 0.1g, chitosan oligosaccharide 0.17g, nutrient yeast powder 0.01g, bird's nest Gly-His-Lys 0.01g, rain
Algae powder 0.01g, broccoli seed water extract 0.1g, Guarana extract 0.1g.
Preferably, the bovine colostrum preparation method the following steps are included:
(1) it chooses the endocrine milk of 2-3d from milk cow farrows and is stored at -3-0 DEG C, obtain ox
Colostrum, it is spare；
(2) colostrum in step (1) is added in the sodium chloride solution that concentration is 5-10%, is sufficiently stirred, then exists
20-30min is centrifuged under conditions of being 4200-4600n/min in revolving speed, removes the fatty and middle layer containing lactose of upper layer
Solution obtains object containing albumen precipitation；
(3) object containing albumen precipitation in step (2) is dissolved in distilled water, with 0.1mol/L hydrochloric acid solution adjust pH to
Then 20-30min is centrifuged in 4-5 under the conditions of revolving speed is 3500-4000n/min, collect supernatant, then use
0.1mol/L sodium hydroxide solution adjusts pH to 6.9-7.1, obtains pretreated bovine colostrum；
(4) pretreated bovine colostrum in step (3) is subjected to pasteurization disinfection at 60-65 DEG C, then in turn through
Cooling is concentrated, and freeze-drying obtains bovine colostrum.
Preferably, the avenabeta glucosan preparation method the following steps are included:
(1) dry oat bran is ground into 60-80 mesh, then extracting pressure is 10-30MPa, extraction temperature is
40-55 DEG C, extraction flow be 3000-4000L/h under conditions of carry out supercritical carbon dioxide extracting 1-4h, remove oat bran
In grease, obtain De-fatted oat bran skin, it is spare；
(2) by the De-fatted oat bran skin in step (1) by solid-liquid ratio 1:10-30 be added deionized water, be added amylase into
Row enzymatic hydrolysis, amylase additive amount are 0.5-2.5%, and hydrolysis temperature is 70-90 DEG C, enzymolysis time 0.5-2.5h, and enzymatic hydrolysis pH is
5-7.5；It adds carbohydrase to be digested, carbohydrase additive amount is 1-4%, and hydrolysis temperature is 60-80 DEG C, enzymolysis time 1-
1.5h, enzymatic hydrolysis pH are 4-6, obtain enzymolysis liquid, spare；
(4) pH of the enzymolysis liquid in step (3) is adjusted to 8.5-10.5, and is 30-90 DEG C in Extracting temperature, when extraction
Between to extract 1-3 times under conditions of 0.5-1.5h, the pH of solution is then adjusted to 3.5-5.5, and be warming up to 85-95 DEG C, added
Hot 1-3h, finally precipitating stands 10-24h, and supernatant is collected in centrifuge separation；
(5) supernatant into step (4) is added protease and is digested, and the additive amount of protease is 2-7%, enzymatic hydrolysis temperature
Degree is 50-70 DEG C, time 2-5h, pH 4-8；Then the chitosan of 0.1-2%, the sodium alginate of 1-4% are successively added, is filled
Divide and stir evenly, and stand 5-10h, separate supernatant, collect suspension, then be centrifuged, collects supernatant, it is spraying to do
It is dry, obtain avenabeta glucosan.
Preferably, the chitosan oligosaccharide preparation method the following steps are included:
(1) dry shrimp and crab shells are ground into 80-120 mesh, the dilute hydrochloric acid that 4-8 times of weight of shrimp and crab shells powder is added is taken off
Calcium, the concentration of dilute hydrochloric acid are 1.5-5%, and filtering leaves and takes solid powder, obtains decalcification shrimp and crab shells powder；
(2) deionized water of its 3-6 times of weight is added into the decalcification shrimp and crab shells powder in step (1), is thoroughly mixed
Uniformly, then the pH of solution is adjusted as 3-6.5, be heated to that enzyme preparation is added at 36-58 DEG C, keep the temperature to be reacted, then
Heat up boiling, obtains mixed solution；
(3) mixed solution in step (2) is separated by solid-liquid separation, is decolourized, be spray-dried, obtain chitosan oligosaccharide.
Preferably, the enzyme preparation in the step (2) for deacetylase and is selected from cellulase, hemicellulase, bacteriolyze
Mixture composed by one of enzyme, chitinase, protease, chitosan enzyme, lipase and glucolase or a variety of enzymes；Institute
State the 45-55% that deacetylase accounts for enzyme preparation；The additional amount of the enzyme preparation be the decalcification shrimp and crab shells powder total weight very much
One of to 1 percent.
Preferably, the bird's nest peptide preparation method the following steps are included:
(1) it after cleaning up bird's nest with deionized water, is air-dried at 35-40 DEG C, is ground into 60-120 mesh, then use gas
Stream comminuting method is crushed to particle diameter at 4-12 μm, obtains thin bird's nest powder, and deionized water then is added according to solid-liquid ratio 1:5-10,
Mixing speed stirs 20-30min under conditions of being 120-150r/min, obtains bird's nest mixing slurry；
(2) the bird's nest mixing slurry in step (1) is placed in nanometer wet process disintegrator and crushes, emulsifies 30-60min, it is described
Bird's nest mixing slurry passes through the comprehensive functions such as multiple shear surface intensive shears, shock, grinding and hole in nanometer wet process disintegrator,
Particle diameter is crushed between 30-120nm, it is then dry under conditions of 40-50 DEG C, obtain pie bird's nest；
(3) the pie bird's nest in step (2) grinding 1-2h in grinder is placed in move back to ultrafine crusher depth powder
The diameter range of particle is broken in 30-180nm, obtains ultra-fine bird's nest powder, deionized water then is added according to solid-liquid ratio 1:10-15 and stirs
It mixes uniformly, then is placed in progress ultrasonic water bath concussion in water-bath tank, water bath time 3-5h, temperature is 70-90 DEG C, obtains ultra-fine swallow
Nest mixed liquor；
(4) the ultra-fine bird's nest mixed liquor in step (3) is subjected to centrifugal ultrafiltration with the ultrafiltration membrane of 7000-8000 dalton,
It is chromatographed again with sephadex column, collects absorption peak component at 300nm, be then freeze-dried, obtain bird's nest Gly-His-Lys.
Inventive formulation can be prepared into commonly edible dosage form, for example, powder according to the conventional formulation technologies of this field
Agent, liquid, paste etc..
The groups such as excipient, preservative, sweetener can also be added when edible dosage form is made in inventive formulation as needed
Point.
Inventive formulation is preferably prepared to pulvis.
The present invention also provides the preparation methods of a kind of immunological regulation and the formula of enhancing physical strength: by bovine colostrum, oat
Beta glucan, albumin Gly-His-Lys, Acerola cherry fruit powder, chitosan oligosaccharide, nutrient yeast powder, bird's nest Gly-His-Lys, haematococcus pluvialis powder, west are blue
Flower seed water extract, Guarana extract are sufficiently mixed uniformly pack.
It is as follows the effect of main component in inventive formulation:
Bovine colostrum: colostrum is milk secreted in 72 hours after healthy cow farrows, and is exempted from containing precious activity
The nutritions such as epidemic disease globulin and milk calcium matter abundant, protein, various trace elements are known as " king that 21 century is immunized ".
Compared with normal cream, content content has dramatically different, and serum colostrum protein content is higher, and fat and sugar content is lower, iron content
It is 10-17 times of common milk, vitamin D and A are respectively 3 times and 10 times of common milk.Colostrum contain panimmunity because
Son, such as active immune globulin, lactoferrin, lactoperoxidase, lysozyme, most important one substance are active immnes
Globulin, content are 10 times or more in often newborn.Immunoglobulin containing five seed types in colostrum, respectively IgA,
IgD, IgE, IgM, IgG, wherein the content of IgG accounts for 80% or more, and characteristic is than other four kinds of stabilizations, is most important function
It can property substance.Numerous studies and clinical test prove that IgG has immunoloregulation function in colostrum, more efficiently can prevent and change
Kind disease, enhances disease resistance, is able to suppress multiple pathogenic microorganisms.Furthermore there are also some other functions for colostrum, such as promote
Growth and development and raising IQ, build up health, improve movenent performance, eliminate fatigue, delay senescence, adjust intestinal flora etc..
Avenabeta glucosan: cereals nutrient is abundant, compared with wheat, rice, seeding corn and other crops, the protein of oat, no
The nutritive indexes such as saturated fatty acid, vitamin, mineral matter element rank among the best, thus oat is full price battalion best in cereal
Support one of food.Oat is generally acknowledged health food again, and oat product is confirmed as health care by United States Food and Drag Administration and is eaten
Product.It is existing studies have shown that avenabeta glucosan be oat play health-care effect critical function composition.Avenabeta glucosan is
A kind of D type glucose polymer formed with (1 → 3) of mixing, (1 → 4)-β-glucosides key connection.Avenabeta glucosan is dropping
The effect of low density lipoprotein cholesterol content in low blood, prevention cardiovascular disease aspect, is especially pronounced；It can also subtract simultaneously
Few absorption of the human body to glucose, delays the hydrolysis of starch, reduces postprandial blood glucose level.In addition, avenabeta glucosan is to pre-
It is anti-and improve heart disease caused by coronary sclerosis, inhibitor against colon carcinoma cells, improve the immunity of the human body, prevent and obesity controlling etc.
All play an important role；Avenabeta glucosan also has prevention and treatment diabetes, promotes proliferation of intestinal probiotics, prevents intestines
The effects of tract disease, strengthen immunity.
Albumin Gly-His-Lys: ovalbumin peptide derives from ovalbumin mother liquor, is extracted using modern biotechnology through digestion
Biologically active micromolecule polypeptide, can directly be absorbed by enteron aisle, bioavailability is high, possesses more functions, more
Be conducive to absorption of human body, the advantage for having its irreplaceable in terms of nutrition and health care.Ovalbumin peptide contains the 20 of needed by human body
The required and nonessential amino acid of kind, can supplement various amino acid needed for body, while itself and human serum albumins ratio of components
Example is closely similar, can replace plasma albumin, maintains plasma colloid osmotic pressure and assists the transhipment of internal many kinds of substance.White egg
White peptide is as small molecular protein peptide,, can be without due to smaller molecular weight while retaining ovalbumin nutritive value
Digestion is directly absorbed by the body, and quickly supplements needed by human body nutrition.Experiment shows: albumin polypeptide has body's immunity
Humidification.Therefore supplement albumin polypeptide can promote the functional rehabilitation of immuning tissue, improve body resistance against diseases.To it is juvenile,
Children and the old invasion for resisting virus and bacterium, enhancing disease resistance is very favorable.Ovalbumin peptide also has enhancing intestines
The breeding of road profitable strain promotes food amplifying nucleic acid in enteron aisle to absorb and more in the distribution of the vitals such as thymus gland, liver etc.
Kind regulatory function.
Acerola cherry fruit powder: studies have shown that in the plant planted at present, Vitamin C content highest in acerola concentrate, often
Victoria C content is up to 1000 milligrams or more in 100 grams of fruits, is approximately 35 times of lemon, and 17 times of strawberry, also than being considered vitamin C pole
High guava is 11 times high, is qualified " king of vitamin C ", while also containing members such as dimension A, dimension B1, dimension B2, iron, calcium
Element, wherein the citrin contained can help ascorbic absorption.The main Wheat Protein of ascorbic physiological function, rush
It absorbed into the synthesis of connective tissue formation, removing toxic substances, promotion neurotransmitter and carnitine, promotion iron, raising immune function, reduce and move
Arteries and veins hardening prevents and controls inflammation.
Chitosan oligosaccharide: chitosan oligosaccharide is β -1-4 Glucosamine oligomer (degree of polymerization 2-20), can be mentioned from the raw materials such as shrimp and crab shells
Degradation is taken to obtain.Chitosan oligosaccharide is unique a large amount of existing alkaline polysaccharides in natural sugar, other than there is the property of similar chitosan,
It also has viscosity low, and good water solubility, molecular weight is small, is easy the advantages that being absorbed and utilized and is degradable, bioactivity and functionality
Matter is all more extensive compared with chitosan.Research shows that chitosan oligosaccharide is very good bioactive substance, has and adjust blood pressure and blood lipoid, resists
Oxidation, it is anti-infective, intestinal flora is adjusted, the various biologicals activity such as immune and antitumor is enhanced.
Nutrient yeast powder: nutritious yeast is a kind of natural nutrient source, has low fat, spy low in calories, low cholesterol
Point, the full nutrition substance containing needed by human body.18 kinds of amino acid in nutritious yeast, having 9 kinds is essential amino acid, energy
Essential amino acid and good protein are enough supplemented, has the effects that slow down musculature degeneration；Beta glucan in nutritious yeast
Equal dietary fibers promote enteron aisle digestion, relax bowel and defecation, toxin-expelling and face nourishing；Nutritious yeast also contains complete VB race, mineral of good quality.
Nutritious yeast also has the effects that beautifying face and moistering lotion, strengthen immunity, improves body energy, promotes brain development.
Bird's nest Gly-His-Lys: bird's nest peptide molecular weight is small, and activity is high, and penetration power is strong, is easy to be absorbed by the body, and be human body cell group
Required exogeneous small molecule peptide is knitted, each function of human body can be preferably adjusted.Bird's nest peptide can significantly reduce skin
Melanin increases skin hydroxyl dried meat amino acid and moisture, and the epidermal growth factor (EGF) contained in bird's nest peptide can promote epidermal tissue
Growth, the division of the various kinds of cell such as epithelial cell, horn cell, fibroblast, it is thin to accelerate skin metabolism, enhancing epidermis
Extracellular matrix components make epidermal cell become full, restore younger state, can also promote collagen growth ability, repair
The collagen elastomer of aging fracture, the sallow situation of the person that significantly improves insufficiency of vital energy and blood dry skin, aging.Swallow in bird's nest peptide
Nest acid can increase absorption of the enteron aisle to vitamin and mineral, obtain the nutrition in other raw materials of the invention more fully sharp
With, additionally it is possible to it improves passive protective physical fitness, improve memory and intelligence, reduce injury of the insufficiency of vital energy and blood to body and brain.
Haematococcus pluvialis powder: haematococcus pluvialis makes frond take on a red color because can largely accumulate astaxanthin (ASTA), therefore named red
Ball algae or haematococcus pluvialis.Astaxanthin in haematococcus pluvialis is one of strongest natural in the world, can be effectively clear
Except intracellular free radical, enhance cytothesis ability, maintain organism balance and reduce the accumulation of senile cell, protects from inside to outside
Cell and DNA health are protected, to protect skin health, promotes hair growth, anti-aging alleviates sports fatigue, invigorates.It
Antioxidant activity be more than existing antioxidant.Its ability for removing free radical is: ascorbic 6000 times；Vitamin E
1000 times；800 times of Co-Q10；Nitric oxide production 1800 times；3100 times of natto；700 times of anthocyanidin；Beta carotene
100 times of effect；10 times of lycopene；200 times of lutein；320 times of tea polyphenols.Astaxanthin tool in haematococcus pluvialis
There are many physiological function, such as in inoxidizability, antitumor, pre- anti-cancer, strengthen immunity, improve eyesight and safeguard nervous centralis
System, it is anti-infective, protect the skin from damage, prevention of arterial hardening, beautifying face and moistering lotion etc. have certain effect.
Guarana: it is perennial that Guarana (Classification system: Paullinia cupana var.sorbilis) belongs to Sapindaceae
Woody climber originates in Brazilian Amazon basin tropical rain forest, has and refreshes the mind, control appetite, alleviate abdominal pain and other effects.Melon
The natural caffeine that Rana is contained exists with the polyphenols of plant inherence itself with complex form, can be mild and lasting
Ground stimulation nerve, thus edible Guarana is more healthy to human body.In addition, Guarana also contain abundant glucose, amino acid,
Fatty acid decomposes to the form for becoming energy in cytoplasm, helps to refresh oneself.
Broccoli seed: in broccoli seed, 90% glucosinolate is glucose sulforaphane
(glucophanin, abbreviation GRA).It is prevalent in due to ESP albumen in the broccoli seed of each kind, GRA is in west
The conversion ratio that sulforaphane (sulforaphane, abbreviation SFA) is converted after the enzymatic hydrolysis of cymbidium seed itself is 10%-
40%, the conversion ratio for being converted into sulforaphane nitrile (sulforaphane nitrile, abbreviation SFN) is 50%-80%.SFA is not
With any cytotoxicity, it is able to suppress the shape of the cancer cells such as lung cancer, cancer of the esophagus, colon cancer, breast cancer, liver cancer and colorectal cancer
At the level of raising tissue glutathione, inducing cell synthesizes II type detoxication enzyme.
Compared with prior art, the invention has the following beneficial effects:
(1) present invention is using several pure natural animals and plants as raw material, and through reasonable compatibility, scientific matching is formed, and has enhancing people
The multi-efficiencies such as body immunity make human body get well state.Wherein, chitosan oligosaccharide and haematococcus pluvialis powder can effectively remove body
Interior free radical improves oxidation resistance, the harmful substances such as discharge toxin, heavy metal；Nutrient yeast powder repairs damaged cell, provides
Nutrition needed for cell enhances cytothesis repair ability；Guarana extract, which has, to refresh the mind, controls appetite, effect of weight reducing；
Broccoli seed water extract improves the level of tissue glutathione, inhibits the formation of cancer cell；Bird's nest Gly-His-Lys can promote cell
Free radical is removed in metabolism, adjusts the effect of body immunity and cell viability；Bovine colostrum, albumin Gly-His-Lys and oat
Beta glucan adjusts intestinal flora, and strengthen immunity improves disease resistance.
(2) the bird's nest Gly-His-Lys in inventive formulation and albumin Gly-His-Lys molecular weight are small, and activity is high, the strong Gly-His-Lys of penetration power,
It is more easier to be absorbed by the body, and is exogeneous small molecule peptide necessary to human cell tissue, can preferably adjusts human body
Each function.
(3) it also added Acerola cherry fruit powder in inventive formulation, can not only be body replenishing vitamins C, additionally it is possible to
Adjusting makes product sweet and sour taste, and mouthfeel is more preferably.Long-term consumption product of the present invention adjustable intestinal flora, mentions strengthen immunity
High body energy builds up health, eliminates fatigue, delays senescence, beautifying face and moistering lotion, and without side-effects, the wide application of the crowd of safety.
Specific embodiment
Specific embodiments of the present invention will be further explained below.It should be noted that for these implementations
The explanation of mode is used to help understand the present invention, but and does not constitute a limitation of the invention.In addition, invention described below
Technical characteristic involved in each embodiment can be combined with each other as long as they do not conflict with each other.
Embodiment 1
The formula of a kind of immunological regulation and enhancing physical strength includes following weight raw material in every bag of 5g formula: bovine colostrum 2g,
Avenabeta glucosan 1.5g, albumin Gly-His-Lys 1g, Acerola cherry fruit powder 0.1g, chitosan oligosaccharide 0.17g, nutrient yeast powder 0.01g, swallow
Nest Gly-His-Lys 0.01g, haematococcus pluvialis powder 0.01g, broccoli seed water extract 0.1g, Guarana extract 0.1g；Preparation method
For said components are sufficiently mixed uniformly pack.
The preparation method of above-mentioned bovine colostrum the following steps are included:
(1) it chooses the endocrine milk of 2-3d from milk cow farrows and is stored at -3-0 DEG C, obtain ox
Colostrum, it is spare；
(2) colostrum in step (1) is added in the sodium chloride solution that concentration is 5-10%, is sufficiently stirred, then exists
20-30min is centrifuged under conditions of being 4200-4600n/min in revolving speed, removes the fatty and middle layer containing lactose of upper layer
Solution obtains object containing albumen precipitation；
(3) object containing albumen precipitation in step (2) is dissolved in distilled water, with 0.1mol/L hydrochloric acid solution adjust pH to
Then 20-30min is centrifuged in 4-5 under the conditions of revolving speed is 3500-4000n/min, collect supernatant, then use
0.1mol/L sodium hydroxide solution adjusts pH to 6.9-7.1, obtains pretreated bovine colostrum；
(4) pretreated bovine colostrum in step (3) is subjected to pasteurization disinfection at 60-65 DEG C, then in turn through
Cooling is concentrated, and freeze-drying obtains bovine colostrum.
The preparation method of above-mentioned avenabeta glucosan the following steps are included:
(1) dry oat bran is ground into 60-80 mesh, then extracting pressure is 10-30MPa, extraction temperature is
40-55 DEG C, extraction flow be 3000-4000L/h under conditions of carry out supercritical carbon dioxide extracting 1-4h, remove oat bran
In grease, obtain De-fatted oat bran skin, it is spare；
(2) by the De-fatted oat bran skin in step (1) by solid-liquid ratio 1:10-30 be added deionized water, be added amylase into
Row enzymatic hydrolysis, amylase additive amount are 0.5-2.5%, and hydrolysis temperature is 70-90 DEG C, enzymolysis time 0.5-2.5h, and enzymatic hydrolysis pH is
5-7.5；It adds carbohydrase to be digested, carbohydrase additive amount is 1-4%, and hydrolysis temperature is 60-80 DEG C, enzymolysis time 1-
1.5h, enzymatic hydrolysis pH are 4-6, obtain enzymolysis liquid, spare；
(4) pH of the enzymolysis liquid in step (3) is adjusted to 8.5-10.5, and is 30-90 DEG C in Extracting temperature, when extraction
Between to extract 1-3 times under conditions of 0.5-1.5h, the pH of solution is then adjusted to 3.5-5.5, and be warming up to 85-95 DEG C, added
Hot 1-3h, finally precipitating stands 10-24h, and supernatant is collected in centrifuge separation；
(5) supernatant into step (4) is added protease and is digested, and the additive amount of protease is 2-7%, enzymatic hydrolysis temperature
Degree is 50-70 DEG C, time 2-5h, pH 4-8；Then the chitosan of 0.1-2%, the sodium alginate of 1-4% are successively added, is filled
Divide and stir evenly, and stand 5-10h, separate supernatant, collect suspension, then be centrifuged, collects supernatant, it is spraying to do
It is dry, obtain avenabeta glucosan.
The preparation method of above-mentioned chitosan oligosaccharide the following steps are included:
(1) dry shrimp and crab shells are ground into 80-120 mesh, the dilute hydrochloric acid that 4-8 times of weight of shrimp and crab shells powder is added is taken off
Calcium, the concentration of dilute hydrochloric acid are 1.5-5%, and filtering leaves and takes solid powder, obtains decalcification shrimp and crab shells powder；
(2) deionized water of its 3-6 times of weight is added into the decalcification shrimp and crab shells powder in step (1), is thoroughly mixed
Uniformly, then the pH of solution is adjusted as 3-6.5, be heated to that enzyme preparation is added at 36-58 DEG C, keep the temperature to be reacted, then
Heat up boiling, obtains mixed solution；The enzyme preparation is deacetylase and be selected from cellulase, hemicellulase, lysozyme, several
Mixture composed by one of fourth matter enzyme, protease, chitosan enzyme, lipase and glucolase or a variety of enzymes；It is described de-
Acetyl enzyme accounts for the 45-55% of enzyme preparation；The additional amount of the enzyme preparation is a ten thousandth of the decalcification shrimp and crab shells powder total weight
To 1 percent；
(3) mixed solution in step (2) is separated by solid-liquid separation, is decolourized, be spray-dried, obtain chitosan oligosaccharide.
The preparation method of above-mentioned bird's nest peptide the following steps are included:
(1) it after cleaning up bird's nest with deionized water, is air-dried at 35-40 DEG C, is ground into 60-120 mesh, then use gas
Stream comminuting method is crushed to particle diameter at 4-12 μm, obtains thin bird's nest powder, and deionized water then is added according to solid-liquid ratio 1:5-10,
Mixing speed stirs 20-30min under conditions of being 120-150r/min, obtains bird's nest mixing slurry；
(2) the bird's nest mixing slurry in step (1) is placed in nanometer wet process disintegrator and crushes, emulsifies 30-60min, it is described
Bird's nest mixing slurry passes through the comprehensive functions such as multiple shear surface intensive shears, shock, grinding and hole in nanometer wet process disintegrator,
Particle diameter is crushed between 30-120nm, it is then dry under conditions of 40-50 DEG C, obtain pie bird's nest；
(3) the pie bird's nest in step (2) grinding 1-2h in grinder is placed in move back to ultrafine crusher depth powder
The diameter range of particle is broken in 30-180nm, obtains ultra-fine bird's nest powder, deionized water then is added according to solid-liquid ratio 1:10-15 and stirs
It mixes uniformly, then is placed in progress ultrasonic water bath concussion in water-bath tank, water bath time 3-5h, temperature is 70-90 DEG C, obtains ultra-fine swallow
Nest mixed liquor；
(4) the ultra-fine bird's nest mixed liquor in step (3) is subjected to centrifugal ultrafiltration with the ultrafiltration membrane of 7000-8000 dalton,
It is chromatographed again with sephadex column, collects absorption peak component at 300nm, be then freeze-dried, obtain bird's nest Gly-His-Lys.
Embodiment 2
The formula of a kind of immunological regulation and enhancing physical strength includes following weight raw material in every bag of 5g formula: bovine colostrum 1g,
Avenabeta glucosan 1.5g, albumin Gly-His-Lys 2g, Acerola cherry fruit powder 0.15g, chitosan oligosaccharide 0.17g, nutrient yeast powder 0.01g,
Bird's nest Gly-His-Lys 0.01g, haematococcus pluvialis powder 0.01g, broccoli seed water extract 0.1g, Guarana extract 0.05g；Preparation side
Method is that said components are sufficiently mixed uniformly pack.
The preparation method of above-mentioned bovine colostrum the following steps are included:
(1) it chooses the endocrine milk of 2-3d from milk cow farrows and is stored at -3-0 DEG C, obtain ox
Colostrum, it is spare；
(2) colostrum in step (1) is added in the sodium chloride solution that concentration is 5-10%, is sufficiently stirred, then exists
20-30min is centrifuged under conditions of being 4200-4600n/min in revolving speed, removes the fatty and middle layer containing lactose of upper layer
Solution obtains object containing albumen precipitation；
(3) object containing albumen precipitation in step (2) is dissolved in distilled water, with 0.1mol/L hydrochloric acid solution adjust pH to
Then 20-30min is centrifuged in 4-5 under the conditions of revolving speed is 3500-4000n/min, collect supernatant, then use
0.1mol/L sodium hydroxide solution adjusts pH to 6.9-7.1, obtains pretreated bovine colostrum；
(4) pretreated bovine colostrum in step (3) is subjected to pasteurization disinfection at 60-65 DEG C, then in turn through
Cooling is concentrated, and freeze-drying obtains bovine colostrum.
The preparation method of above-mentioned avenabeta glucosan the following steps are included:
(1) dry oat bran is ground into 60-80 mesh, then extracting pressure is 10-30MPa, extraction temperature is
40-55 DEG C, extraction flow be 3000-4000L/h under conditions of carry out supercritical carbon dioxide extracting 1-4h, remove oat bran
In grease, obtain De-fatted oat bran skin, it is spare；
(2) by the De-fatted oat bran skin in step (1) by solid-liquid ratio 1:10-30 be added deionized water, be added amylase into
Row enzymatic hydrolysis, amylase additive amount are 0.5-2.5%, and hydrolysis temperature is 70-90 DEG C, enzymolysis time 0.5-2.5h, and enzymatic hydrolysis pH is
5-7.5；It adds carbohydrase to be digested, carbohydrase additive amount is 1-4%, and hydrolysis temperature is 60-80 DEG C, enzymolysis time 1-
1.5h, enzymatic hydrolysis pH are 4-6, obtain enzymolysis liquid, spare；
(4) pH of the enzymolysis liquid in step (3) is adjusted to 8.5-10.5, and is 30-90 DEG C in Extracting temperature, when extraction
Between to extract 1-3 times under conditions of 0.5-1.5h, the pH of solution is then adjusted to 3.5-5.5, and be warming up to 85-95 DEG C, added
Hot 1-3h, finally precipitating stands 10-24h, and supernatant is collected in centrifuge separation；
(5) supernatant into step (4) is added protease and is digested, and the additive amount of protease is 2-7%, enzymatic hydrolysis temperature
Degree is 50-70 DEG C, time 2-5h, pH 4-8；Then the chitosan of 0.1-2%, the sodium alginate of 1-4% are successively added, is filled
Divide and stir evenly, and stand 5-10h, separate supernatant, collect suspension, then be centrifuged, collects supernatant, it is spraying to do
It is dry, obtain avenabeta glucosan.
The preparation method of above-mentioned chitosan oligosaccharide the following steps are included:
(1) dry shrimp and crab shells are ground into 80-120 mesh, the dilute hydrochloric acid that 4-8 times of weight of shrimp and crab shells powder is added is taken off
Calcium, the concentration of dilute hydrochloric acid are 1.5-5%, and filtering leaves and takes solid powder, obtains decalcification shrimp and crab shells powder；
(2) deionized water of its 3-6 times of weight is added into the decalcification shrimp and crab shells powder in step (1), is thoroughly mixed
Uniformly, then the pH of solution is adjusted as 3-6.5, be heated to that enzyme preparation is added at 36-58 DEG C, keep the temperature to be reacted, then
Heat up boiling, obtains mixed solution；The enzyme preparation is deacetylase and be selected from cellulase, hemicellulase, lysozyme, several
Mixture composed by one of fourth matter enzyme, protease, chitosan enzyme, lipase and glucolase or a variety of enzymes；It is described de-
Acetyl enzyme accounts for the 45-55% of enzyme preparation；The additional amount of the enzyme preparation is a ten thousandth of the decalcification shrimp and crab shells powder total weight
To 1 percent；
(3) mixed solution in step (2) is separated by solid-liquid separation, is decolourized, be spray-dried, obtain chitosan oligosaccharide.
The preparation method of above-mentioned bird's nest peptide the following steps are included:
(1) it after cleaning up bird's nest with deionized water, is air-dried at 35-40 DEG C, is ground into 60-120 mesh, then use gas
Stream comminuting method is crushed to particle diameter at 4-12 μm, obtains thin bird's nest powder, and deionized water then is added according to solid-liquid ratio 1:5-10,
Mixing speed stirs 20-30min under conditions of being 120-150r/min, obtains bird's nest mixing slurry；
(2) the bird's nest mixing slurry in step (1) is placed in nanometer wet process disintegrator and crushes, emulsifies 30-60min, it is described
Bird's nest mixing slurry passes through the comprehensive functions such as multiple shear surface intensive shears, shock, grinding and hole in nanometer wet process disintegrator,
Particle diameter is crushed between 30-120nm, it is then dry under conditions of 40-50 DEG C, obtain pie bird's nest；
(3) the pie bird's nest in step (2) grinding 1-2h in grinder is placed in move back to ultrafine crusher depth powder
The diameter range of particle is broken in 30-180nm, obtains ultra-fine bird's nest powder, deionized water then is added according to solid-liquid ratio 1:10-15 and stirs
It mixes uniformly, then is placed in progress ultrasonic water bath concussion in water-bath tank, water bath time 3-5h, temperature is 70-90 DEG C, obtains ultra-fine swallow
Nest mixed liquor；
(4) the ultra-fine bird's nest mixed liquor in step (3) is subjected to centrifugal ultrafiltration with the ultrafiltration membrane of 7000-8000 dalton,
It is chromatographed again with sephadex column, collects absorption peak component at 300nm, be then freeze-dried, obtain bird's nest Gly-His-Lys.
Embodiment 3
The formula of a kind of immunological regulation and enhancing physical strength includes following weight raw material in every bag of 5g formula: bovine colostrum 3g,
Avenabeta glucosan 0.5g, albumin Gly-His-Lys 1g, Acerola cherry fruit powder 0.05g, chitosan oligosaccharide 0.17g, nutrient yeast powder 0.01g,
Bird's nest Gly-His-Lys 0.01g, haematococcus pluvialis powder 0.01g, broccoli seed water extract 0.1g, Guarana extract 0.15g；Preparation side
Method is that said components are sufficiently mixed uniformly pack.
The preparation method of above-mentioned bovine colostrum the following steps are included:
(1) it chooses the endocrine milk of 2-3d from milk cow farrows and is stored at -3-0 DEG C, obtain ox
Colostrum, it is spare；
(2) colostrum in step (1) is added in the sodium chloride solution that concentration is 5-10%, is sufficiently stirred, then exists
20-30min is centrifuged under conditions of being 4200-4600n/min in revolving speed, removes the fatty and middle layer containing lactose of upper layer
Solution obtains object containing albumen precipitation；
(3) object containing albumen precipitation in step (2) is dissolved in distilled water, with 0.1mol/L hydrochloric acid solution adjust pH to
Then 20-30min is centrifuged in 4-5 under the conditions of revolving speed is 3500-4000n/min, collect supernatant, then use
0.1mol/L sodium hydroxide solution adjusts pH to 6.9-7.1, obtains pretreated bovine colostrum；
(4) pretreated bovine colostrum in step (3) is subjected to pasteurization disinfection at 60-65 DEG C, then in turn through
Cooling is concentrated, and freeze-drying obtains bovine colostrum.
The preparation method of above-mentioned avenabeta glucosan the following steps are included:
(1) dry oat bran is ground into 60-80 mesh, then extracting pressure is 10-30MPa, extraction temperature is
40-55 DEG C, extraction flow be 3000-4000L/h under conditions of carry out supercritical carbon dioxide extracting 1-4h, remove oat bran
In grease, obtain De-fatted oat bran skin, it is spare；
(2) by the De-fatted oat bran skin in step (1) by solid-liquid ratio 1:10-30 be added deionized water, be added amylase into
Row enzymatic hydrolysis, amylase additive amount are 0.5-2.5%, and hydrolysis temperature is 70-90 DEG C, enzymolysis time 0.5-2.5h, and enzymatic hydrolysis pH is
5-7.5；It adds carbohydrase to be digested, carbohydrase additive amount is 1-4%, and hydrolysis temperature is 60-80 DEG C, enzymolysis time 1-
1.5h, enzymatic hydrolysis pH are 4-6, obtain enzymolysis liquid, spare；
(4) pH of the enzymolysis liquid in step (3) is adjusted to 8.5-10.5, and is 30-90 DEG C in Extracting temperature, when extraction
Between to extract 1-3 times under conditions of 0.5-1.5h, the pH of solution is then adjusted to 3.5-5.5, and be warming up to 85-95 DEG C, added
Hot 1-3h, finally precipitating stands 10-24h, and supernatant is collected in centrifuge separation；
(5) supernatant into step (4) is added protease and is digested, and the additive amount of protease is 2-7%, enzymatic hydrolysis temperature
Degree is 50-70 DEG C, time 2-5h, pH 4-8；Then the chitosan of 0.1-2%, the sodium alginate of 1-4% are successively added, is filled
Divide and stir evenly, and stand 5-10h, separate supernatant, collect suspension, then be centrifuged, collects supernatant, it is spraying to do
It is dry, obtain avenabeta glucosan.
The preparation method of above-mentioned chitosan oligosaccharide the following steps are included:
(1) dry shrimp and crab shells are ground into 80-120 mesh, the dilute hydrochloric acid that 4-8 times of weight of shrimp and crab shells powder is added is taken off
Calcium, the concentration of dilute hydrochloric acid are 1.5-5%, and filtering leaves and takes solid powder, obtains decalcification shrimp and crab shells powder；
(2) deionized water of its 3-6 times of weight is added into the decalcification shrimp and crab shells powder in step (1), is thoroughly mixed
Uniformly, then the pH of solution is adjusted as 3-6.5, be heated to that enzyme preparation is added at 36-58 DEG C, keep the temperature to be reacted, then
Heat up boiling, obtains mixed solution；The enzyme preparation is deacetylase and be selected from cellulase, hemicellulase, lysozyme, several
Mixture composed by one of fourth matter enzyme, protease, chitosan enzyme, lipase and glucolase or a variety of enzymes；It is described de-
Acetyl enzyme accounts for the 45-55% of enzyme preparation；The additional amount of the enzyme preparation is a ten thousandth of the decalcification shrimp and crab shells powder total weight
To 1 percent；
(3) mixed solution in step (2) is separated by solid-liquid separation, is decolourized, be spray-dried, obtain chitosan oligosaccharide.
The preparation method of above-mentioned bird's nest peptide the following steps are included:
(1) it after cleaning up bird's nest with deionized water, is air-dried at 35-40 DEG C, is ground into 60-120 mesh, then use gas
Stream comminuting method is crushed to particle diameter at 4-12 μm, obtains thin bird's nest powder, and deionized water then is added according to solid-liquid ratio 1:5-10,
Mixing speed stirs 20-30min under conditions of being 120-150r/min, obtains bird's nest mixing slurry；
(2) the bird's nest mixing slurry in step (1) is placed in nanometer wet process disintegrator and crushes, emulsifies 30-60min, it is described
Bird's nest mixing slurry passes through the comprehensive functions such as multiple shear surface intensive shears, shock, grinding and hole in nanometer wet process disintegrator,
Particle diameter is crushed between 30-120nm, it is then dry under conditions of 40-50 DEG C, obtain pie bird's nest；
(3) the pie bird's nest in step (2) grinding 1-2h in grinder is placed in move back to ultrafine crusher depth powder
The diameter range of particle is broken in 30-180nm, obtains ultra-fine bird's nest powder, deionized water then is added according to solid-liquid ratio 1:10-15 and stirs
It mixes uniformly, then is placed in progress ultrasonic water bath concussion in water-bath tank, water bath time 3-5h, temperature is 70-90 DEG C, obtains ultra-fine swallow
Nest mixed liquor；
(4) the ultra-fine bird's nest mixed liquor in step (3) is subjected to centrifugal ultrafiltration with the ultrafiltration membrane of 7000-8000 dalton,
It is chromatographed again with sephadex column, collects absorption peak component at 300nm, be then freeze-dried, obtain bird's nest Gly-His-Lys.
Embodiment 4
The formula of a kind of immunological regulation and enhancing physical strength includes following weight raw material: bovine colostrum in every bag of 5g formula
0.5g, avenabeta glucosan 2g, albumin Gly-His-Lys 2g, Acerola cherry fruit powder 0.1g, chitosan oligosaccharide 0.17g, nutrient yeast powder
0.01g, bird's nest Gly-His-Lys 0.01g, haematococcus pluvialis powder 0.01g, broccoli seed water extract 0.1g, Guarana extract 0.1g；
Preparation method is that said components are sufficiently mixed uniformly pack.
The preparation method of above-mentioned bovine colostrum the following steps are included:
(1) it chooses the endocrine milk of 2-3d from milk cow farrows and is stored at -3-0 DEG C, obtain ox
Colostrum, it is spare；
(2) colostrum in step (1) is added in the sodium chloride solution that concentration is 5-10%, is sufficiently stirred, then exists
20-30min is centrifuged under conditions of being 4200-4600n/min in revolving speed, removes the fatty and middle layer containing lactose of upper layer
Solution obtains object containing albumen precipitation；
(3) object containing albumen precipitation in step (2) is dissolved in distilled water, with 0.1mol/L hydrochloric acid solution adjust pH to
Then 20-30min is centrifuged in 4-5 under the conditions of revolving speed is 3500-4000n/min, collect supernatant, then use
0.1mol/L sodium hydroxide solution adjusts pH to 6.9-7.1, obtains pretreated bovine colostrum；
(4) pretreated bovine colostrum in step (3) is subjected to pasteurization disinfection at 60-65 DEG C, then in turn through
Cooling is concentrated, and freeze-drying obtains bovine colostrum.
The preparation method of above-mentioned avenabeta glucosan the following steps are included:
(1) dry oat bran is ground into 60-80 mesh, then extracting pressure is 10-30MPa, extraction temperature is
40-55 DEG C, extraction flow be 3000-4000L/h under conditions of carry out supercritical carbon dioxide extracting 1-4h, remove oat bran
In grease, obtain De-fatted oat bran skin, it is spare；
(2) by the De-fatted oat bran skin in step (1) by solid-liquid ratio 1:10-30 be added deionized water, be added amylase into
Row enzymatic hydrolysis, amylase additive amount are 0.5-2.5%, and hydrolysis temperature is 70-90 DEG C, enzymolysis time 0.5-2.5h, and enzymatic hydrolysis pH is
5-7.5；It adds carbohydrase to be digested, carbohydrase additive amount is 1-4%, and hydrolysis temperature is 60-80 DEG C, enzymolysis time 1-
1.5h, enzymatic hydrolysis pH are 4-6, obtain enzymolysis liquid, spare；
(4) pH of the enzymolysis liquid in step (3) is adjusted to 8.5-10.5, and is 30-90 DEG C in Extracting temperature, when extraction
Between to extract 1-3 times under conditions of 0.5-1.5h, the pH of solution is then adjusted to 3.5-5.5, and be warming up to 85-95 DEG C, added
Hot 1-3h, finally precipitating stands 10-24h, and supernatant is collected in centrifuge separation；
(5) supernatant into step (4) is added protease and is digested, and the additive amount of protease is 2-7%, enzymatic hydrolysis temperature
Degree is 50-70 DEG C, time 2-5h, pH 4-8；Then the chitosan of 0.1-2%, the sodium alginate of 1-4% are successively added, is filled
Divide and stir evenly, and stand 5-10h, separate supernatant, collect suspension, then be centrifuged, collects supernatant, it is spraying to do
It is dry, obtain avenabeta glucosan.
The preparation method of above-mentioned chitosan oligosaccharide the following steps are included:
(1) dry shrimp and crab shells are ground into 80-120 mesh, the dilute hydrochloric acid that 4-8 times of weight of shrimp and crab shells powder is added is taken off
Calcium, the concentration of dilute hydrochloric acid are 1.5-5%, and filtering leaves and takes solid powder, obtains decalcification shrimp and crab shells powder；
(2) deionized water of its 3-6 times of weight is added into the decalcification shrimp and crab shells powder in step (1), is thoroughly mixed
Uniformly, then the pH of solution is adjusted as 3-6.5, be heated to that enzyme preparation is added at 36-58 DEG C, keep the temperature to be reacted, then
Heat up boiling, obtains mixed solution；The enzyme preparation is deacetylase and be selected from cellulase, hemicellulase, lysozyme, several
Mixture composed by one of fourth matter enzyme, protease, chitosan enzyme, lipase and glucolase or a variety of enzymes；It is described de-
Acetyl enzyme accounts for the 45-55% of enzyme preparation；The additional amount of the enzyme preparation is a ten thousandth of the decalcification shrimp and crab shells powder total weight
To 1 percent；
(3) mixed solution in step (2) is separated by solid-liquid separation, is decolourized, be spray-dried, obtain chitosan oligosaccharide.
The preparation method of above-mentioned bird's nest peptide the following steps are included:
(1) it after cleaning up bird's nest with deionized water, is air-dried at 35-40 DEG C, is ground into 60-120 mesh, then use gas
Stream comminuting method is crushed to particle diameter at 4-12 μm, obtains thin bird's nest powder, and deionized water then is added according to solid-liquid ratio 1:5-10,
Mixing speed stirs 20-30min under conditions of being 120-150r/min, obtains bird's nest mixing slurry；
(2) the bird's nest mixing slurry in step (1) is placed in nanometer wet process disintegrator and crushes, emulsifies 30-60min, it is described
Bird's nest mixing slurry passes through the comprehensive functions such as multiple shear surface intensive shears, shock, grinding and hole in nanometer wet process disintegrator,
Particle diameter is crushed between 30-120nm, it is then dry under conditions of 40-50 DEG C, obtain pie bird's nest；
(3) the pie bird's nest in step (2) grinding 1-2h in grinder is placed in move back to ultrafine crusher depth powder
The diameter range of particle is broken in 30-180nm, obtains ultra-fine bird's nest powder, deionized water then is added according to solid-liquid ratio 1:10-15 and stirs
It mixes uniformly, then is placed in progress ultrasonic water bath concussion in water-bath tank, water bath time 3-5h, temperature is 70-90 DEG C, obtains ultra-fine swallow
Nest mixed liquor；
(4) the ultra-fine bird's nest mixed liquor in step (3) is subjected to centrifugal ultrafiltration with the ultrafiltration membrane of 7000-8000 dalton,
It is chromatographed again with sephadex column, collects absorption peak component at 300nm, be then freeze-dried, obtain bird's nest Gly-His-Lys.
Embodiment 5
The formula of a kind of immunological regulation and enhancing physical strength includes following weight raw material in every bag of 5g formula: bovine colostrum 1g,
Avenabeta glucosan 2g, albumin Gly-His-Lys 1.5g, Acerola cherry fruit powder 0.1g, chitosan oligosaccharide 0.17g, nutrient yeast powder 0.01g, swallow
Nest Gly-His-Lys 0.01g, haematococcus pluvialis powder 0.01g, broccoli seed water extract 0.1g, Guarana extract 0.1g；Preparation method
For said components are sufficiently mixed uniformly pack.
The preparation method of above-mentioned bovine colostrum the following steps are included:
(1) it chooses the endocrine milk of 2-3d from milk cow farrows and is stored at -3-0 DEG C, obtain ox
Colostrum, it is spare；
(2) colostrum in step (1) is added in the sodium chloride solution that concentration is 5-10%, is sufficiently stirred, then exists
20-30min is centrifuged under conditions of being 4200-4600n/min in revolving speed, removes the fatty and middle layer containing lactose of upper layer
Solution obtains object containing albumen precipitation；
(3) object containing albumen precipitation in step (2) is dissolved in distilled water, with 0.1mol/L hydrochloric acid solution adjust pH to
Then 20-30min is centrifuged in 4-5 under the conditions of revolving speed is 3500-4000n/min, collect supernatant, then use
0.1mol/L sodium hydroxide solution adjusts pH to 6.9-7.1, obtains pretreated bovine colostrum；
(4) pretreated bovine colostrum in step (3) is subjected to pasteurization disinfection at 60-65 DEG C, then in turn through
Cooling is concentrated, and freeze-drying obtains bovine colostrum.
The preparation method of above-mentioned avenabeta glucosan the following steps are included:
(1) dry oat bran is ground into 60-80 mesh, then extracting pressure is 10-30MPa, extraction temperature is
40-55 DEG C, extraction flow be 3000-4000L/h under conditions of carry out supercritical carbon dioxide extracting 1-4h, remove oat bran
In grease, obtain De-fatted oat bran skin, it is spare；
(2) by the De-fatted oat bran skin in step (1) by solid-liquid ratio 1:10-30 be added deionized water, be added amylase into
Row enzymatic hydrolysis, amylase additive amount are 0.5-2.5%, and hydrolysis temperature is 70-90 DEG C, enzymolysis time 0.5-2.5h, and enzymatic hydrolysis pH is
5-7.5；It adds carbohydrase to be digested, carbohydrase additive amount is 1-4%, and hydrolysis temperature is 60-80 DEG C, enzymolysis time 1-
1.5h, enzymatic hydrolysis pH are 4-6, obtain enzymolysis liquid, spare；
(4) pH of the enzymolysis liquid in step (3) is adjusted to 8.5-10.5, and is 30-90 DEG C in Extracting temperature, when extraction
Between to extract 1-3 times under conditions of 0.5-1.5h, the pH of solution is then adjusted to 3.5-5.5, and be warming up to 85-95 DEG C, added
Hot 1-3h, finally precipitating stands 10-24h, and supernatant is collected in centrifuge separation；
(5) supernatant into step (4) is added protease and is digested, and the additive amount of protease is 2-7%, enzymatic hydrolysis temperature
Degree is 50-70 DEG C, time 2-5h, pH 4-8；Then the chitosan of 0.1-2%, the sodium alginate of 1-4% are successively added, is filled
Divide and stir evenly, and stand 5-10h, separate supernatant, collect suspension, then be centrifuged, collects supernatant, it is spraying to do
It is dry, obtain avenabeta glucosan.
The preparation method of above-mentioned chitosan oligosaccharide the following steps are included:
(1) dry shrimp and crab shells are ground into 80-120 mesh, the dilute hydrochloric acid that 4-8 times of weight of shrimp and crab shells powder is added is taken off
Calcium, the concentration of dilute hydrochloric acid are 1.5-5%, and filtering leaves and takes solid powder, obtains decalcification shrimp and crab shells powder；
(2) deionized water of its 3-6 times of weight is added into the decalcification shrimp and crab shells powder in step (1), is thoroughly mixed
Uniformly, then the pH of solution is adjusted as 3-6.5, be heated to that enzyme preparation is added at 36-58 DEG C, keep the temperature to be reacted, then
Heat up boiling, obtains mixed solution；The enzyme preparation is deacetylase and be selected from cellulase, hemicellulase, lysozyme, several
Mixture composed by one of fourth matter enzyme, protease, chitosan enzyme, lipase and glucolase or a variety of enzymes；It is described de-
Acetyl enzyme accounts for the 45-55% of enzyme preparation；The additional amount of the enzyme preparation is a ten thousandth of the decalcification shrimp and crab shells powder total weight
To 1 percent；
(3) mixed solution in step (2) is separated by solid-liquid separation, is decolourized, be spray-dried, obtain chitosan oligosaccharide.
The preparation method of above-mentioned bird's nest peptide the following steps are included:
(1) it after cleaning up bird's nest with deionized water, is air-dried at 35-40 DEG C, is ground into 60-120 mesh, then use gas
Stream comminuting method is crushed to particle diameter at 4-12 μm, obtains thin bird's nest powder, and deionized water then is added according to solid-liquid ratio 1:5-10,
Mixing speed stirs 20-30min under conditions of being 120-150r/min, obtains bird's nest mixing slurry；
(2) the bird's nest mixing slurry in step (1) is placed in nanometer wet process disintegrator and crushes, emulsifies 30-60min, it is described
Bird's nest mixing slurry passes through the comprehensive functions such as multiple shear surface intensive shears, shock, grinding and hole in nanometer wet process disintegrator,
Particle diameter is crushed between 30-120nm, it is then dry under conditions of 40-50 DEG C, obtain pie bird's nest；
(3) the pie bird's nest in step (2) grinding 1-2h in grinder is placed in move back to ultrafine crusher depth powder
The diameter range of particle is broken in 30-180nm, obtains ultra-fine bird's nest powder, deionized water then is added according to solid-liquid ratio 1:10-15 and stirs
It mixes uniformly, then is placed in progress ultrasonic water bath concussion in water-bath tank, water bath time 3-5h, temperature is 70-90 DEG C, obtains ultra-fine swallow
Nest mixed liquor；
(4) the ultra-fine bird's nest mixed liquor in step (3) is subjected to centrifugal ultrafiltration with the ultrafiltration membrane of 7000-8000 dalton,
It is chromatographed again with sephadex column, collects absorption peak component at 300nm, be then freeze-dried, obtain bird's nest Gly-His-Lys.
Above the embodiments of the present invention are described in detail, but the present invention is not limited to described embodiments.It is right
For those skilled in the art, in the case where not departing from the principle of the invention and spirit, these embodiments are carried out more
Kind change, modification, replacement and modification, still fall in protection scope of the present invention.
Claims (9)
1. the formula of a kind of immunological regulation and enhancing physical strength, it is characterised in that: include following weight raw material: ox in every bag of 5g formula
Colostrum powder 0.5-5g, avenabeta glucosan 0.5-5g, albumin Gly-His-Lys 0.5-5g, Acerola cherry fruit powder 0.01-0.5g, chitosan oligosaccharide
0.01-0.3g, nutrient yeast powder 0.001-0.01g, bird's nest Gly-His-Lys 0.001-0.01g, haematococcus pluvialis powder 0.001-0.01g,
Broccoli seed water extract 0.01-0.3g, Guarana extract 0.01-0.5g.
2. the formula of immunological regulation according to claim 1 and enhancing physical strength, it is characterised in that: include in every bag of 5g formula
Following weight raw material: bovine colostrum 1-5g, avenabeta glucosan 1-5g, albumin Gly-His-Lys 1-5g, Acerola cherry fruit powder 0.05-
0.5g, chitosan oligosaccharide 0.05-0.3g, nutrient yeast powder 0.005-0.01g, bird's nest Gly-His-Lys 0.005-0.01g, haematococcus pluvialis powder
0.005-0.01g, broccoli seed water extract 0.1-0.3g, Guarana extract 0.05-0.5g.
3. the formula of immunological regulation according to claim 2 and enhancing physical strength, it is characterised in that: include in every bag of 5g formula
Following weight raw material: bovine colostrum 2g, avenabeta glucosan 1.5g, albumin Gly-His-Lys 1g, Acerola cherry fruit powder 0.1g, chitosan oligosaccharide
0.17g, nutrient yeast powder 0.01g, bird's nest Gly-His-Lys 0.01g, haematococcus pluvialis powder 0.01g, broccoli seed water extract 0.1g, melon
Rana extract 0.1g.
4. the formula of immunological regulation according to claim 1-3 and enhancing physical strength, it is characterised in that: at the beginning of the ox
The preparation method of milk powder the following steps are included:
(1) it chooses the endocrine milk of 2-3d from milk cow farrows and is stored at -3-0 DEG C, obtain colostrum,
It is spare；
(2) colostrum in step (1) is added in the sodium chloride solution that concentration is 5-10%, is sufficiently stirred, then in revolving speed
For 20-30min is centrifuged under conditions of 4200-4600n/min, the fatty and middle layer molten containing lactose of upper layer is removed
Liquid obtains object containing albumen precipitation；
(3) object containing albumen precipitation in step (2) is dissolved in distilled water, adjusts pH to 4-5 with 0.1mol/L hydrochloric acid solution,
Then 20-30min is centrifuged under the conditions of revolving speed is 3500-4000n/min, collects supernatant, then use 0.1mol/L
Sodium hydroxide solution adjusts pH to 6.9-7.1, obtains pretreated bovine colostrum；
(4) pretreated bovine colostrum in step (3) is subjected to pasteurization disinfection at 60-65 DEG C, then in turn through cooling,
Concentration, freeze-drying, obtains bovine colostrum.
5. the formula of immunological regulation according to claim 1-3 and enhancing physical strength, it is characterised in that: the oat
The preparation method of beta glucan the following steps are included:
(1) dry oat bran is ground into 60-80 mesh, then extracting pressure be 10-30MPa, extraction temperature 40-55
DEG C, extraction flow be 3000-4000L/h under conditions of carry out supercritical carbon dioxide extracting 1-4h, remove oat bran in
Grease obtains De-fatted oat bran skin, spare；
(2) deionized water is added by solid-liquid ratio 1:10-30 in the De-fatted oat bran skin in step (1), amylase is added and carries out enzyme
Solution, amylase additive amount are 0.5-2.5%, and it is 5- that hydrolysis temperature, which is 70-90 DEG C, enzymolysis time 0.5-2.5h, enzymatic hydrolysis pH,
7.5；It adds carbohydrase to be digested, carbohydrase additive amount is 1-4%, and hydrolysis temperature is 60-80 DEG C, enzymolysis time 1-
1.5h, enzymatic hydrolysis pH are 4-6, obtain enzymolysis liquid, spare；
(4) pH of the enzymolysis liquid in step (3) is adjusted to 8.5-10.5, and is 30-90 DEG C in Extracting temperature, extraction time is
It is extracted under conditions of 0.5-1.5h 1-3 times, the pH of solution is then adjusted to 3.5-5.5, and be warming up to 85-95 DEG C, heat 1-
3h, finally precipitating stands 10-24h, and supernatant is collected in centrifuge separation；
(5) supernatant into step (4) is added protease and is digested, and the additive amount of protease is 2-7%, and hydrolysis temperature is
50-70 DEG C, time 2-5h, pH 4-8；Then the chitosan of 0.1-2%, the sodium alginate of 1-4% are successively added, is sufficiently stirred
It mixes uniformly, and stands 5-10h, separate supernatant, collect suspension, then be centrifuged, collect supernatant, be spray-dried,
Obtain avenabeta glucosan.
6. the formula of immunological regulation according to claim 1-3 and enhancing physical strength, it is characterised in that: the shell is few
Sugar preparation method the following steps are included:
(1) dry shrimp and crab shells are ground into 80-120 mesh, the dilute hydrochloric acid that 4-8 times of weight of shrimp and crab shells powder is added carries out decalcification, dilute
The concentration of hydrochloric acid is 1.5-5%, and filtering leaves and takes solid powder, obtains decalcification shrimp and crab shells powder；
(2) deionized water of its 3-6 times of weight is added into the decalcification shrimp and crab shells powder in step (1), is thoroughly mixed uniformly,
The pH for adjusting solution again is 3-6.5, is heated to that enzyme preparation is added at 36-58 DEG C, the temperature is kept to be reacted, and then heating is steamed
It boils, obtains mixed solution；
(3) mixed solution in step (2) is separated by solid-liquid separation, is decolourized, be spray-dried, obtain chitosan oligosaccharide.
7. the formula of immunological regulation according to claim 6 and enhancing physical strength, it is characterised in that: in the step (2)
Enzyme preparation is deacetylase and is selected from cellulase, hemicellulase, lysozyme, chitinase, protease, chitosan enzyme, rouge
Mixture composed by one of fat enzyme and glucolase or a variety of enzymes；The deacetylase accounts for the 45-55% of enzyme preparation；Institute
The additional amount for stating enzyme preparation is a ten thousandth of the decalcification shrimp and crab shells powder total weight to 1 percent.
8. the formula of immunological regulation according to claim 1-3 and enhancing physical strength, it is characterised in that: the bird's nest
The preparation method of peptide the following steps are included:
(1) it after cleaning up bird's nest with deionized water, is air-dried at 35-40 DEG C, is ground into 60-120 mesh, then use air-flow powder
Broken method is crushed to particle diameter at 4-12 μm, obtains thin bird's nest powder, and deionized water then is added according to solid-liquid ratio 1:5-10, is stirring
Speed stirs 20-30min under conditions of being 120-150r/min, obtains bird's nest mixing slurry；
(2) the bird's nest mixing slurry in step (1) is placed in nanometer wet process disintegrator and crushes, emulsifies 30-60min, the bird's nest
Mixing slurry, by comprehensive functions such as multiple shear surface intensive shears, shock, grinding and holes, crushes in nanometer wet process disintegrator
It is then dry under conditions of 40-50 DEG C to particle diameter between 30-120nm, obtain pie bird's nest；
(3) the pie bird's nest in step (2) is placed in grinder and grinds 1-2h and moves back to ultrafine crusher depth and be crushed to
The diameter range of particle obtains ultra-fine bird's nest powder in 30-180nm, and it is equal that deionized water stirring then is added according to solid-liquid ratio 1:10-15
It is even, then it is placed in progress ultrasonic water bath concussion in water-bath tank, water bath time 3-5h, temperature is 70-90 DEG C, and it is mixed to obtain ultra-fine bird's nest
Close liquid；
(4) the ultra-fine bird's nest mixed liquor in step (3) is subjected to centrifugal ultrafiltration with the ultrafiltration membrane of 7000-8000 dalton, then used
Sephadex column chromatography, collects absorption peak component at 300nm, is then freeze-dried, obtains bird's nest Gly-His-Lys.
9. a kind of preparation method of the formula of immunological regulation according to claim 1-3 and enhancing physical strength, special
Sign is: by bovine colostrum, avenabeta glucosan, albumin Gly-His-Lys, Acerola cherry fruit powder, chitosan oligosaccharide, nutrient yeast powder, bird's nest
Gly-His-Lys, haematococcus pluvialis powder, broccoli seed water extract, Guarana extract be sufficiently mixed uniformly pack.
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