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CN118104672A - Synergistic compound binary composition of two active components and application thereof - Google Patents

Synergistic compound binary composition of two active components and application thereof Download PDF

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Publication number
CN118104672A
CN118104672A CN202211520879.3A CN202211520879A CN118104672A CN 118104672 A CN118104672 A CN 118104672A CN 202211520879 A CN202211520879 A CN 202211520879A CN 118104672 A CN118104672 A CN 118104672A
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China
Prior art keywords
component
composition
species
flonicamid
active components
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CN202211520879.3A
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Chinese (zh)
Inventor
刘少武
张俊龙
范晓溪
呼健洋
徐靖博
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Jiangsu Youjia Plant Protection Co ltd
Jiangsu Yangnong Chemical Co Ltd
Shenyang Sinochem Agrochemicals R&D Co Ltd
Original Assignee
Jiangsu Youjia Plant Protection Co ltd
Jiangsu Yangnong Chemical Co Ltd
Shenyang Sinochem Agrochemicals R&D Co Ltd
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Application filed by Jiangsu Youjia Plant Protection Co ltd, Jiangsu Yangnong Chemical Co Ltd, Shenyang Sinochem Agrochemicals R&D Co Ltd filed Critical Jiangsu Youjia Plant Protection Co ltd
Priority to CN202211520879.3A priority Critical patent/CN118104672A/en
Priority to PCT/CN2023/128516 priority patent/WO2024114260A1/en
Publication of CN118104672A publication Critical patent/CN118104672A/en
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/02—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms
    • A01N43/24—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with two or more hetero atoms
    • A01N43/26—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with two or more hetero atoms five-membered rings
    • A01N43/28—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with two or more hetero atoms five-membered rings with two hetero atoms in positions 1,3
    • A01N43/30—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with two or more hetero atoms five-membered rings with two hetero atoms in positions 1,3 with two oxygen atoms in positions 1,3, condensed with a carbocyclic ring
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/34—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom
    • A01N43/40—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom six-membered rings
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
    • A01N43/54—1,3-Diazines; Hydrogenated 1,3-diazines
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/64—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with three nitrogen atoms as the only ring hetero atoms
    • A01N43/707—1,2,3- or 1,2,4-triazines; Hydrogenated 1,2,3- or 1,2,4-triazines
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N53/00—Biocides, pest repellants or attractants, or plant growth regulators containing cyclopropane carboxylic acids or derivatives thereof
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01P—BIOCIDAL, PEST REPELLANT, PEST ATTRACTANT OR PLANT GROWTH REGULATORY ACTIVITY OF CHEMICAL COMPOUNDS OR PREPARATIONS
    • A01P7/00—Arthropodicides
    • A01P7/02—Acaricides
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01P—BIOCIDAL, PEST REPELLANT, PEST ATTRACTANT OR PLANT GROWTH REGULATORY ACTIVITY OF CHEMICAL COMPOUNDS OR PREPARATIONS
    • A01P7/00—Arthropodicides
    • A01P7/04—Insecticides

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  • Life Sciences & Earth Sciences (AREA)
  • Plant Pathology (AREA)
  • Environmental Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Pest Control & Pesticides (AREA)
  • Health & Medical Sciences (AREA)
  • Agronomy & Crop Science (AREA)
  • Dentistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Chemical & Material Sciences (AREA)
  • Insects & Arthropods (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

The invention belongs to the field of pesticides, and relates to a synergistic compound composition containing two active components. Contains A, B two active components, wherein the component A is selected from the following structural compounds, and the component B is selected from pymetrozine, flonicamid (flonicamid), propiconazole (afidopyropen), pyriproxyfen, praziquantel (pyrifluquinazon), trifluoro-pyrim (triflumizopyrim) and fluhexafon, benzpyrimoxan, tyclopyrazoflor; the weight part ratio of the two active components of the component A, B is 1:50 to 50:1, a step of; the composition has obvious synergistic effect and can be used for preventing and controlling various pests.

Description

Synergistic compound binary composition of two active components and application thereof
Technical Field
The invention belongs to the field of pesticides, and relates to a synergistic compound binary composition of two active components and application thereof.
Background
The chemical pesticide is used as an important guarantee for stable yield and high harvest of crops, and plays an irreplaceable role in pest control.
The pesticides such as pymetrozine, flonicamid (flonicamid), propiconazole (afidopyropen), praziquantel (pyrifluquinazon) and the like are insecticidal products which have blocking effects on the oral needles of piercing-sucking pests, so that the pests stop eating immediately and finally starve and kill the pests. The pesticide has good control effect on piercing-sucking mouthparts pests of various crops, has contact killing effect on the pests, and has systemic activity.
Trifluoro-pyrimidyl belongs to a novel pyrimidine compound, is a novel intermediate ion pesticide, acts on the nicotinic acetylcholine receptor (nAChR) of insects, but has a mechanism of action different from that of the neonicotinoid pesticide, and the trifluoro-pyrimidyl is combined with the n-site on the nAChR through competition, inhibits the combined site, reduces nerve impulse of the insects or blocks nerve transmission, finally influences physiological behaviors such as feeding, reproduction and the like of the insects, and causes death.
However, continuous high dose administration of a single chemical agent over a long period of time is likely to cause a series of problems such as residue of the agent and environmental pollution. The reasonable chemical agent compounding or compounding has the positive characteristics of expanding the insecticidal spectrum, improving the control effect, prolonging the application period, reducing the dosage, reducing the phytotoxicity, reducing the residue, delaying the occurrence and development of the drug resistance of pests, and the like.
The Chinese patent CN112457288 discloses a piperic acid derivative and application thereof, wherein the compound I-72 has contact killing and stomach poisoning activities and good conduction activities, and can be used for preventing and controlling various pests such as lepidoptera, hemiptera, thysanoptera, coleoptera and the like. The structural formula of the compound is as follows:
The compounding of different varieties of components can produce some unexpected technical effects, and is also one of effective methods for preventing and controlling resistant pests. However, no report on a compound I-72 and ingestion-retarding pesticide compound exists so far.
Disclosure of Invention
The invention aims to provide a synergistic compound binary composition of two active components and application thereof.
The technical scheme adopted by the invention for realizing the purposes is as follows:
A synergistic compound binary composition of two active components comprises A, B two active components, wherein component A is selected from compounds (namely, compounds I-72) with the following structures, and component B is selected from insect ingestion retarding insecticides; the weight part ratio of the two active components of the component A, B is 1:50 to 50:1, a step of; wherein, the structural formula of the component A compound is as follows:
The component B is selected from insect ingestion retarding pesticides: b1 pymetrozine, B2 flonicamid (flonicamid), B3 ditetracycline (afidopyropen), B4 pyripyropene, B5 praziquanzon (pyrifluquinazon), B6 trifluorobenzene pyrimidine (triflumezopyrrom), B7 fluhexafon, B8 benzpyrimoxan, B9 tyclopyrazoflor.
Preferably, in the composition, component A is selected from the compounds represented by the above structural formula; the component B is selected from B1 pymetrozine, B2 flonicamid (flonicamid), B3 dipropylene glycol (afidopyropen), B4 pyriproxyfen, B5 praziquanzon, B6 trifluorobenzene pyrimidine (triflumizopyrim), B7fluhexafon and B8 benzpyrimoxan, B9 tyclopyrazoflor;
the weight part ratio of the two active components of the component A, B is 1:20 to 20:1.
Further preferably, in the composition, component a is selected from the compounds represented by the above structural formula; the component B is selected from B1 pymetrozine, B2 flonicamid (flonicamid), B3 dipropionate (afidopyropen), B5 praziquantel (pyrifluquinazon) and B6 trifluoro-benzene pyrimidine (triflumezopyrrom);
the weight part ratio of the two active components of the component A, B is 1:10 to 10:1.
Use of a composition for the manufacture of a pesticide for controlling pests on fruit trees, vegetables, ornamental plants, tea, cotton, cereal crops, shrubs, broad-leaved trees, evergreen trees or urban hygiene pests.
The use of the composition for preventing or controlling lepidoptera, hemiptera, homoptera, coleoptera, diptera, thysanoptera, acarina pests and their larvae and eggs.
The synergistic compound composition of the invention has obvious synergistic effect when being used for controlling pests on fruit trees, vegetables, ornamental plants, tea, cotton, cereal crops, shrubs, broad-leaved trees and evergreen trees or urban sanitary pests. The indoor biological activity measurement results show that the compound I-72 is mixed with pymetrozine, flonicamid, hydroprene, praziquantel and trifluoperazine to improve the control effect, reduce the dosage and enlarge the insecticidal spectrum. For example, when compound I-72 is combined with pymetrozine, flonicamid, propiconazole, praziquantel in 1:10 to 10:1, the activity of targets such as cotton aphids, peach aphids, brown planthoppers, corn borers, thrips and bemisia tabaci can be greatly improved when the targets are mixed within the proportion range; a large number of experiments show that after the compound I-72 is mixed with the 5 pesticides, the compound has obvious synergistic trend along with the increase of the compound amount, and the application of the compound in the field is facilitated. Therefore, the two active component synergistic compound composition can be used for preparing pesticide medicines.
The synergistic compound composition can be used for preventing and controlling pests, underground pests or urban sanitary pests on fruit trees, vegetables, ornamental plants, tea, cotton, cereal crops, shrubs, broad-leaved trees, evergreen trees and the like; can be used for preventing and controlling sucking mouthparts pests on various crops, such as plant hoppers, white flies, aphids, thrips, leafhoppers, stinkbugs, spider mites, striped rice borers, corn borers, plutella xylostella, armyworms, leaf miners, cotton bollworms, asparagus caterpillars, termites and other pests and urban sanitary pests.
In particular, the synergistic formulated compositions of the present invention are particularly useful for controlling hemipteran pests, a non-exhaustive list of which includes, but is not limited to: lygus lucorum (Acrosternum hilare), lygus lucorum (GREEN STINK bug), lygus lucorum (Blissus leucopterus), lygus lucorum (branch bug), lygus lucorum (Blissus leucopterus), lygus lucorum, tropical bed bugs (Blissus leucopterus), tropical bed bugs, temperature zone bugs (Blissus leucopterus), bed bugs, lygus lucorum (Blissus leucopterus), stinkbug (Blissus leucopterus), black cotton-wing red domains (Blissus leucopterus), cotton bugs, blissus leucopterus, cereal bugs (Blissus leucopterus), brown stinkbug (euchistus her) in the new tropical region, brown stinkbug (Blissus leucopterus), brown stinkbug, lygus lucorum (Blissus leucopterus), lygus lucorum, blissus leucopterus spp stinkbug, lygus grandis (Blissus leucopterus), lygus species (Lygus spp.), lygus lucorum (Blissus leucopterus), lygus westerni, lygus syriacus (Blissus leucopterus), lygus longus (Blissus leucopterus), lygus lucorum, south green stinkbug, lygus plant species (Blissus leucopterus spp.), lygus lucorum, lygus calium (Blissus leucopterus), lygus personatus (Blissus leucopterus), blissus leucopterus, lygus quadricarinus (Blissus leucopterus), lygus lucorum, lygus cowberry (Blissus leucopterus), avocado net stinkbug (Blissus leucopterus), lygus lucorum (Blissus leucopterus), and stinkbug species (Blissus leucopterus spp.) Blood sucking trypanosoma and stinkbug (bloodsucking conenose bugs/kissing bugs).
In particular, the synergistic formulated composition of the present invention is particularly useful for controlling homopteran pests (aphids, scale insects, whiteflies, planthoppers, leafhoppers), a non-exhaustive list of which include, but are not limited to: pea aphid (Acrythosiphon pisum), pea aphid, aphid species (Adelges spp.), cabbage whitefly (Aleurodes proletella), cabbage whitefly, spiral whitefly (Aleurodicus disperses), soft white fly (Aleurothrixus floccosus), Bemisia tabaci, leptospira species (Aluacaspis spp.), amrasca bigutella bigutella, paecilomyces species (Aphrophora spp.), leafhoppers, peptospira citrifolia (Aonidiella aurantii), peptospira citrifolia, aphis gossypii (Aphis spp.), aphis gossypii, aphis apple (Aphis pomi), aphis apple, aphis solani (Aulacorthum solani), Digitalis aphid, bemisia spp, bemisia tabaci Bemisia argentifolii, bemisia tabaci, mylabris gracilis Brachycolus noxius Russian aphid, asparagus aphid (Brachycorynella asparagi), asparagus aphid, rice flour scale insect (Brevennia rehi), cabbage aphid (Brevicoryne brassicae), cabbage aphid, Scale insects of the genus Lepidium (Ceroplastes spp.), red mealybugs (Ceroplastes rubens), red mealybugs (Chionaspis spp.), scale insects of the genus Lepidium (Chrysomphalus spp.), scale insects of the genus Phpidium scale insects of the genus lecanii (Coccus spp.), psyllium (DYSAPHIS PLANTAGINEA), apple pink inferior aphid, leafhoppers of the genus leafhopper (Empoasca spp.), and, Aphis citricola (Eriosoma lanigerum), aphis citricola, eriophorus prandis (Icerya purchasi), aphis citricola, phaeda citrifolia (Idioscopus nitidulus), phaeda citrifolia, laodelphax striatellus (Laodelphax striatellus), phaeda citrifolia, pedalus species (Lepidosaphes spp.), alasprinus species (Macrosiphum spp.), aphis potato aphid (Macrosiphum euphorbiae), Potato aphid, wheat long tube aphid (Macrosiphum granarium), british wheat aphid, rose long tube aphid (Macrosiphum rosae), rose aphid, emerald green leaf hopper (Macrosteles quadrilineatus), aster leaf hopper raspberry foam cicada (MAHANARVA FRIMBIOLATA), wheat clear net aphid (Metopolophium dirhodum), rose wheat long tube aphid, stinkbug (Mictis longicornis), peach aphid (Myzus persicae), Leafhoppers of the species Equidae, eichhornia (Nephotettix spp.), eichhornia (Nephotettix cinctipes), eichhornia crassipes, oryza sativa (NILAPARVATA LUGENS), brown planthoppers, pithecellon (Parlatoria pergandii), pithecellon (Parlatoria ziziphi), ukappaphycus, corn planthoppers (Peregrinus maidis), corn wing planthoppers, eichhornia longicosa (Philaenus spp.), the aphids of the species Leptosphaeria (Phylloxera vitifoliae), leptosphaeria (Physokermes piceae), leptosphaeria (Cryptosporidium) and Leptosphaeria (Planococcus spp.), leptosphaeria (Pseudococcus spp.), leptosphaeria (Pseudococcus brevipes), leptosphaeria (Pinus) and Leptosphaeria (Quadraspidiotus perniciosus), leptosphaeria sanguinea and Leptosphaeria (Rhapalosiphum spp.), Corn She Ya (Rhapalosiphummaida), corn aphid, cereal Gu Yiguan aphid (Rhapalosiphum padi), cereal aphid, scale insect of the genus Erinaceus species (SAISSETIA spp.), olive black scale insect (SAISSETIA OLEAE), black scale insect, wheat binary aphid (Schizaphis graminum), green aphid, wheat long tube aphid (Sitobion avena), UK wheat aphid, white back rice (Sogatella furcifera), white back planthopper, white back plant hopper, Aphids of the species Aphis (Therioaphis spp.), scale insects of the species Tortoise (Toumeyella spp.), aphids of the species Aphis (Toxoptera spp.), whiteflies of the species Bemisia (Trialeurodes spp.), white fly (Trialeurodes vaporariorum), white fly (Trialeurodes abutiloneus), white fly (Bemisia) of the greenhouse, scale insects of the species Tortoise (Unaspis spp.), white fly (Succinum) of the species Tortoise (Unaspis spp.), Leptospha (Unaspis yanonensis), apocyni Veneti, and Zulia entreriana.
In particular, the synergistic formulated compositions of the present invention are particularly useful for controlling thysanoptera pests (thrips), a non-exhaustive list of which includes, but is not limited to: tabaci Thrips (FRANKLINIELLA FUSCA), tabaci Thrips, frankliniella occidentalis (FRANKLINIELLA OCCIDENTALIS), frankliniella occidentalis (FRANKLINIELLA SHULTZEI), frankliniella occidentalis (FRANKLINIELLA WILLIAMSI), corn Thrips, frankliniella occidentalis (Heliothrips haemorrhaidalis), greenhouse Thrips, grape Thrips (Riphiphorothrips cruentatus), hard Thrips species (Scirtothrips spp.), citrus fruit hard Thrips (Scirtothrips citri), citrus Thrips, tea yellow Thrips (Scirtothrips dorsalis), tea yellow Thrips, ribbon Thrips (Taeniothrips rhopalantennalis) and Thrips species (threps spp.).
In particular, the synergistic formulated compositions of the present invention are particularly useful for controlling coleopteran (beetle) pests, a non-exhaustive list of which includes, but is not limited to: tripterygium species (Acanthoscelides spp.), elephantopus, green bean image (Acanthoscelides obtectus), soyabean image, white wax narrow-gilding (Agrilus planipennis), white wax tree borer, click beetle species (Agriotes spp.), iron wire worm, acromium nucifera (Anoplophora glabripennis), and white wax narrow-gilding (Agrilus planipennis), Asian longhornbeetles, hua species (Anthonomus spp.), weevils, mexico cotton bollworms (Anthonomus grandis), cotton bollworms, aphidius species (Aphidius spp.), rhizopus elongatus species (Apion spp.), weevils, saccharum species (Apogonia spp.), grubs, tortoise (Ataenius spretulus), grass beetles, beetles (Atomaria linearis), beetles, melon species (Aulacophora spp.), and other species, Beet weevil (Bothynoderes punctiventris), beet root weevil, brucea spp, pea weevil (Bruchus pisorum), pea weevil, cacoesia species tetrad weevil (Callosobruchus maculatus), cowpea weevil (Carpophilus hemipteras), dried fruit beetles, beet tortoise shell (CASSIDA VITTATA), cerosterna species, Cerotoma genus species, phyllanthus emblica (Cerotoma trifurcata), phyllanthus emblica, tortoise species (Ceutorhynchus spp.), cabbage seed tortoise (Ceutorhynchus assimilis), cabbage weevil, lilac daphne (Ceutorhynchus napi), cabbage weevil, tiepia species (Chaetocnema spp.), zodiac genus species (cologis spp.), soil beetles, trichlungus bougainvillea (Conoderus scalaris), Multiple spots of wide chest flammulina (Conoderus stigmosus), li Xiangbi (Conotrachelus nenuphar), conus, mossback (Cotinus nitidis), yellow chafer, asparagus negative mud worm (Crioceris asparagi), asparagus, rust red flat valley (Cryptolestes ferrugineus), rust flat valley (Cryptolestes pusillus), long angle flat valley (Cryptolestes pusillus), flat valley (Cryptolestes turcicus), turkish flat valley (Cryptolestes turcicus), Turkish Gu Jiachong, click beetle species (CTENICERA spp.), elephantopus species (Curculio spp.), square beetle species (Cyclocephala spp.), armyworm (Cylindrocpturus adspersus), sunflower stem weevil, fruit scissors She Xiangjia (Deporaus marginatus), mango leaf weevil, bark beetle (DERMESTES LARDARIUS), bark beetle (DERMESTES MACULATES), Beetle, beetle species (Diabrotica spp.) chrysolemid, ladybug (EPILACHNA VARIVESTIS), beetle, borer (Faustinus cubae), weevil (Hylobius pales), jatropha, fork leaf species (Hypera spp.), alfalfa She Xiangjia (Hypera postica), alfalfa leaf weevil, hyperdoes species, argan weevil, coffee cherry bark beetle (Hypothenemus hampei), beetle, and other species, Coffee berry beetles, bark beetles species (Ips spp.), sculptures beetles, tobacco beetles (Lasioderma serricorne), tobacco beetles, potato beetles (Leptinotarsa decemlineata), colorado potato beetles, tortoises (Liogenys fuscus), striped turtles (Liogenys suturalis), rice weevils (Lissorhoptrus oryzophilus), rice weevils, pinus species (Lyctus spp.), and combinations thereof, Wood beetle, flour beetle, maecolaspis joliveti, MEGASCELIS species, corn click beetle (Melanotus communis), vegetable flower beetle species (MELIGETHES spp.), rape flower beetle (MELIGETHES AENEUS), flower beetle, chinese chestnut branchia hornet (Melolontha melolontha), common European beetle, calf longhorn beetle (Oberea brevis), linear longhorn beetle (Oberea linearis), Coconut Rhinocerotis sinensis (Oryctes rhinoceros), jujube beetle, rhizopus macrophylla (Oryzaephilus mercator), rhizopus macrophylla (Oryzaephilus surinamensis), sawtooth Gu Jiachong, rhinocerotis species (Otiorhynchus spp.), nitidea nigricans (Oulema melanopus), gu She beetle, oryza sativa (Oulema oryzae), rhinoceros species (Pantomorus spp.), tochu species, tochu-tussilago species (Oryzaephilus surinamensis), The species of the genus Tortoise gill (Phyllophaga spp.), the species of the genus Tortoise of the genus July/July, the species of the genus Tortoise of the genus July (Phyllophaga cuyabana), the species of the genus Populus (Phyllotreta spp.), the species of the species Populus flavomarginata (Phyllotreta vittuta Fabr.), the species of the species Populus flavomarginata, the species Populus Huang Zhitiao, the species Populus Huang Xiatiao, the species Populus Huang Kuantiao, the species of the species Populus phyllanthus, the species of the species Populus apple (PHYNCHITES spp), the species Populus japonica (Popillia japonica), the species Populus japonica, The species of beetles (Prostephanus truncates), codling (Rhizopertha dominica), small Gu Changdu, root gill chafer species (Rhizotrogus spp.), chafer, cryptogenius species (Rhynchophorus spp.), codling species (Scolytus spp.), wood beetles, shenophorus species (coral beetles), rhizobia (Sitona lineatus), pisifera, elephantopus species (Sitophilus spp.), and, Cereal weevil, rice weevil (Sitophilus granaries), cereal weevil, rice weevil (Sitophilus oryzae), rice weevil, small bark beetle (Stegobium paniceum), beetle, anthropomorphic species (Tribolium spp.), flour weevil, red flour beetle (Triboliumcastaneum), hybrid flour beetle (Tribolium confusum), flour beetle, bark beetle (Trogoderma variabile), and other plant species, Warehouse beetles and greedy steps beetles (Zabrus tenebioides).
Particularly, the synergistic compound composition can be used for preventing and controlling pests such as two-spotted spider mites, tetranychus cinnabarinus, citrus leaf miners, citrus scale insects, fruit tree leaf miners, fruit tree borers, soybean borers, golden moth, tea geometrid, tea caterpillar, tea leafhoppers, pear psyllids, rice planthoppers, greenhouse white flies, liriomyza sativae, yellow striped flea beetles, chilo suppressalis, tryporyza incertulas, corn borers, pod borers, melon silk borers, rice weevils, cotton bollworms, red bollworms, aphids, soybean aphids, cabbage aphids, wheat aphids, cotton aphids, diamond back moths, armyworms, cabbage caterpillars, mosquitoes, flies, cockroaches, termites and the like or urban sanitary pests.
The synergistic compound composition can be applied to pests/mites and/or habitats thereof to be controlled in an effective dosage, so that the synergistic compound composition provided by the invention provides a method for controlling or preventing plant pests.
The active ingredients in the synergistic formulated composition of the present invention may be applied to the pests, plants and their habitat simultaneously (e.g. as a pre-formulated mixture or tank mix) or in a suitable order.
The invention has the advantages that: the binary composition obtained by compounding the compound I-72 with pymetrozine, flonicamid, hydroprene, praziquantel and trifluoperazine in a proper proportion has good synergistic effect, so that the control effect is improved, the dosage is reduced, and the insecticidal spectrum is enlarged. Specifically: 1. the two active components of the compound A, B have different action mechanisms, and can delay the generation of drug resistance of pests. 2. The insecticidal spectrum is enlarged, and the insecticidal composition can be used for preventing and controlling various pests on various crops such as fruit trees, vegetables, ornamental plants, tea, cotton and the like; 3. the pesticide consumption is reduced, the residual quantity of the pesticide on crops is reduced, and the environmental friendliness is enhanced. 4. A, B the two active components are compounded in a proper proportion range, so that the control effect on pests such as cotton aphids, brown planthoppers, huang Jima, peach aphids and the like is improved.
Detailed Description
The following examples are presented to illustrate the invention in detail to facilitate a further understanding of the invention. The active component A is selected from a compound I-72 (the content is 97% obtained by the preparation of the patent document of CN 112457288); the active component B and other raw materials are all commercial products, and the components are measured according to weight percent.
Example 1: compound I-72 and pymetrozine mixed indoor combined virulence determination test for green peach aphids
Test target: myzus persicae (Sulzer) Myzus persicae, sensitive strain raised indoors.
Preparing a liquid medicine: according to different test requirements, accurately weighing samples by using an electronic analytical balance, dissolving the raw materials with acetone, and diluting with 0.1% Tween 80 water according to the test design dose to obtain a series of liquid medicines with a certain concentration gradient.
The test method comprises the following steps: firstly, cabbage leaves with tidy and consistent green peach aphids are selected, the insect carrying capacity of each leaf is about 30-40, then the cabbage leaves are uniformly sprayed from low dose to high dose according to the test design, each leaf is 1.5mL, each treatment is repeated for 3 times, and a blank control is additionally arranged.
The treated test material is placed in an observation chamber, and the temperature, humidity and illumination of the observation chamber can be adjusted as required. After 48 hours, the death rate and the living worm number are investigated, the corrected death rate is calculated by abbott formula, the DPS data processing software is used for statistical analysis, the virulence regression equation, LC 50 value and 95% confidence limit of each tested single agent and each mixed proportion are obtained, the co-virulence coefficient of each proportion is calculated by Sun cloud Peel (Sun y-p) method, the mixed use effect is evaluated, and the test result is shown in Table 1.
The co-toxicity coefficient (CTC value) of the blend was calculated according to the following formula:
Wherein: the ATI-mixed agent actually measures the toxicity index; LC 50 of S-standard agent; LC 50 of M-mix.
TTI＝TIA×PA+TIB×PB
Wherein: TTI-mixed agent theoretical virulence index; TIA-A medicament toxicity index; the percentage of the PA-A agent in the mixture; TIB-B agent virulence index; the PB-B medicament comprises the following components in percentage by weight.
Wherein: CTC-co-toxicity coefficient; the ATI-mixed agent actually measures the toxicity index; TTI-blend theoretical virulence index.
Co-toxicity coefficient (CTC) of the combination agent: CTC is more than or equal to 120 and shows synergistic effect; 120< ctc <120 appears as additive; CTC.ltoreq.120 shows antagonism.
Table 1 results of indoor Combined toxicity determination of the pymetrozine pair by mixing Compounds I-72 and pymetrozine
Example 2: indoor combined toxicity test for cotton aphids by mixing compound I-72 with flonicamid
Test target: if Aphis gossypii (Aphis gossypii Glover) is the Aphis gossypii, the sensitive strain is raised indoors.
Preparing a liquid medicine: according to different test requirements, accurately weighing samples by using an electronic analytical balance, dissolving the raw materials with acetone, and diluting with 0.1% Tween 80 water according to the test design dose to obtain a series of liquid medicines with a certain concentration gradient.
The test method comprises the following steps: firstly, cotton leaves with tidy and consistent cotton aphids are selected, the insect carrying capacity of each leaf is about 30-40, then, the cotton leaves are uniformly sprayed according to the sequence from low dose to high dose according to the test design, each leaf is 1.5mL, each treatment is repeated for 3 times, and a blank control is additionally arranged.
The treated test material is placed in an observation chamber, and the temperature, humidity and illumination of the observation chamber can be adjusted as required. After 48 hours, the death rate and the living worm number are investigated, the corrected death rate are calculated by abbott formula, the DPS data processing software is used for statistical analysis, the virulence regression equation, the LC 50 value and the 95% confidence limit of each tested single agent and each mixed agent with different mixture ratio are obtained, the co-toxicity coefficient of each mixture ratio is calculated by Sun cloud Peel (Sun y-p) method, and the mixed effect is evaluated (same as in example 1), and the test result is shown in Table 2.
Table 2 results of measurement of indoor Combined toxicity of Compound I-72 and flonicamid to Aphis gossypii
Example 3: indoor combined toxicity test for brown planthoppers by mixing compound I-72 and trifluoro-pyrimidyl
Test target: sensitive strain raised indoors by brown planthoppers [ NILAPARVATA LUGENS (Stal) ] nymphs.
Preparing a liquid medicine: according to different test requirements, accurately weighing samples by using an electronic analytical balance, dissolving the raw materials with acetone, and diluting with 0.1% Tween 80 water according to the test design dose to obtain a series of liquid medicines with a certain concentration gradient.
The test method comprises the following steps: the activity of the brown planthopper nymphs was determined by spraying potted seedlings. Firstly, planting rice seedlings in a culture pot, uniformly spraying 2mL of rice plantlets from low dose to high dose according to a test design, then grafting the brown planthoppers nymphs with the same size on the rice seedlings, repeating for 3 times per treatment, and additionally setting a blank control.
The treated test material is placed in an observation chamber, and the temperature, humidity and illumination of the observation chamber can be adjusted as required. After 72 hours, the death rate and the living worm number are investigated, the corrected death rate are calculated by abbott formula, the DPS data processing software is used for statistical analysis, the virulence regression equation, the LC 50 value and the 95% confidence limit of each tested single agent and each mixed agent with different mixture ratio are obtained, the co-toxicity coefficient of each mixture ratio is calculated by Sun cloud Peel (Sun y-p) method, and the mixed effect is evaluated (same as in example 1), and the test result is shown in Table 3.
TABLE 3 determination of indoor Combined toxicity of Compound I-72 and Triflubenine to Nilaparvata lugens
Example 4: indoor combined toxicity test for meadow by mixing compound I-72 with hydroprene
Test target: the nymphs of Lecanis aculeatus (Unaspis yanonensisKuwana).
Preparing a liquid medicine: according to different test requirements, accurately weighing samples by using an electronic analytical balance, dissolving the raw materials with acetone, and diluting with 0.1% Tween 80 water according to the test design dose to obtain a series of liquid medicines with a certain concentration gradient.
The test method comprises the following steps: the activity of the orange diaphorina fasciata nymphs is measured by an immersion method. Firstly, the collected citrus leaves carrying the nymphs of the diaphorina spinosa are treated according to the sequence from low dose to high dose of test design, the stems are moisturized by absorbent cotton after being dried, and then the citrus leaves are placed in a culture dish, and a blank control is additionally arranged every 3 times of treatment.
The treated test material is placed in an observation chamber, and the temperature, humidity and illumination of the observation chamber can be adjusted as required. The number of dead and alive insects was investigated after 120 hours. The corrected mortality was calculated using the abbott formula, statistical analysis was performed using DPS data processing software to determine the virulence regression equation, LC 50 value and 95% confidence limits for each individual agent tested and each blend of different formulations, and co-toxicity coefficients for each formulation were calculated using the grand cloud Pei (Sun y-p) method to evaluate the blend effect (same as in example 1), and the test results are shown in Table 4.
TABLE 4 determination of indoor Combined toxicity of Dipropisochlor and Compound I-72
Example 5: indoor combined toxicity test for Bemisia tabaci nymph by mixing compound I-72 with praziquantel (pyrifluquinazon)
Test target: bemisia tabaci (Bemisia tabaci) nymphs, sensitive lines raised indoors.
Preparing a liquid medicine: according to different test requirements, accurately weighing samples by using an electronic analytical balance, dissolving the raw materials with acetone, and diluting with 0.1% Tween 80 water according to the test design dose to obtain a series of liquid medicines with a certain concentration gradient.
The test method comprises the following steps: cotton leaves with tidy and consistent bemisia tabaci nymphs are firstly selected to be made into leaf discs, the carrier amount of each leaf disc is about 20, then the cotton leaves are uniformly sprayed according to the sequence from low dose to high dose according to the test design, each leaf is 1.5mL, each treatment is repeated for 3 times, and a blank control is additionally arranged.
The treated test material is placed in an observation chamber, and the temperature, humidity and illumination of the observation chamber can be adjusted as required. After 96 hours, the death rate and the living worm number are investigated, the corrected death rate are calculated by abbott formula, the DPS data processing software is used for statistical analysis, the virulence regression equation, the LC 50 value and the 95% confidence limit of each tested single agent and each mixed agent with different proportions are obtained, the co-toxicity coefficient of each proportion is calculated by Sun Yunpei (Sun y-p) method, and the mixed effect is evaluated (same as in example 1), and the test result is shown in table 5.
TABLE 5 determination of indoor combined toxicity of Compound I-72 and Praziquantel Azole to Bemisia tabaci nymphs
Example 6: indoor combined toxicity determination test for thrips by mixing compound I-72 with flonicamid
Test target: huang Jima (Thrips flavus Schrank) nymphs.
Preparing a liquid medicine: according to different test requirements, accurately weighing samples by using an electronic analytical balance, dissolving the raw materials with acetone, and diluting with 0.1% Tween 80 water according to the test design dose to obtain a series of liquid medicines with a certain concentration gradient.
The test method comprises the following steps: eggplant seedlings carrying thrips are firstly selected, the cardinal number is counted, the eggplant seedlings are uniformly sprayed according to the sequence from low dose to high dose according to the experimental design, each plant is 2mL, each treatment is repeated for 3 times, and a blank control is additionally arranged.
The treated test material is placed in an observation chamber, and the temperature, humidity and illumination of the observation chamber can be adjusted as required. After 48 hours, the death rate and the living worm number are investigated, the corrected death rate are calculated by abbott formula, the DPS data processing software is used for statistical analysis, the virulence regression equation, the LC 50 value and the 95% confidence limit of each tested single agent and each mixed agent with different mixture ratio are obtained, the co-toxicity coefficient of each mixture ratio is calculated by Sun cloud Peel (Sun y-p) method, and the mixed effect is evaluated (same as in example 1), and the test result is shown in Table 6.
Table 6 results of indoor Combined toxicity measurements on Fluopicolide by mixing Compound I-72 with flonicamid
Example 7: indoor combined toxicity test for corn borer by mixing compound I-72 with pymetrozine
Test target: corn borer (Ostrinia furnacnlis Guenee) 3-instar larvae.
Preparing a liquid medicine: according to different test requirements, accurately weighing samples by using an electronic analytical balance, dissolving the raw materials with acetone, and diluting with 0.1% Tween 80 water according to the test design dose to obtain a series of liquid medicines with a certain concentration gradient.
The test method comprises the following steps: firstly, selecting tender corns, immersing the tender corns in prepared liquid medicine for 10s according to the sequence from low dose to high dose of test design, naturally drying in the shade, placing the tender corns in a culture dish with the diameter of 9cm and placing filter paper in the culture dish, inoculating regular healthy test insects, repeating for 3 times every treatment for 10 heads, and additionally setting blank control.
The treated test material is placed in an observation chamber, and the temperature, humidity and illumination of the observation chamber can be adjusted as required. After 72 hours, the death rate and the living worm number are investigated, the corrected death rate are calculated by abbott formula, the DPS data processing software is used for statistical analysis, the virulence regression equation, the LC 50 value and the 95% confidence limit of each tested single agent and each mixed agent with different mixture ratio are obtained, the co-toxicity coefficient of each mixture ratio is calculated by Sun cloud Peel (Sun y-p) method, and the mixed effect is evaluated (same as in example 1), and the test result is shown in Table 7.
Table 7 results of indoor Combined toxicity measurements of corn borers by mixing Compound I-72 with pymetrozine
The above description of the embodiments is only for aiding in the understanding of the method of the present invention and its core ideas. It should be noted that it will be apparent to those skilled in the art that various modifications and adaptations of the invention can be made without departing from the principles of the invention and these modifications and adaptations are intended to be within the scope of the invention as defined in the following claims. According to the technical scheme, the synergistic compound composition has the advantages of improving the pesticide effect, expanding the insecticidal spectrum, reducing the pesticide consumption, reducing the residual quantity of the pesticide on crops, reducing the pollution to the environment, being safe to people and livestock, having good environmental compatibility and being difficult for pests to generate drug resistance. The composition can be applied to the control of various pests of various crops, and can be widely applied to the field of agriculture.

Claims (6)

1. A synergistic compound binary composition of two active components is characterized in that: the composition comprises A, B active components, wherein the component A is selected from compounds with the following structures, and the component B is selected from insect ingestion retarding pesticides; the weight part ratio of the two active components of the component A, B is 1:50 to 50:1, a step of; wherein, the structural formula of the component A compound is as follows:
2. The composition of claim 1, wherein: the component B is selected from insect ingestion retarding pesticides: b1 pymetrozine, B2 flonicamid (flonicamid), B3 ditetracycline (afidopyropen), B4 pyripyropene, B5 praziquanzon (pyrifluquinazon), B6 trifluorobenzene pyrimidine (triflumezopyrrom), B7 fluhexafon, B8 benzpyrimoxan, B9 tyclopyrazoflor.
3. Composition according to claim 1 or 2, characterized in that: in the composition, the component A is selected from compounds shown in the structural formula; the component B is selected from B1 pymetrozine, B2 flonicamid (flonicamid), B3 dipropylene glycol (afidopyropen), B4 pyriproxyfen, B5 praziquanzon, B6 trifluorobenzene pyrimidine (triflumizopyrim), B7 fluhexafon and B8 benzpyrimoxan, B9 tyclopyrazoflor;
the weight part ratio of the two active components of the component A, B is 1:20 to 20:1.
4. A composition according to claim 3, characterized in that: in the composition, the component A is selected from compounds shown in the structural formula; the component B is selected from B1 pymetrozine, B2 flonicamid (flonicamid), B3 dipropionate (afidopyropen), B5 praziquantel (pyrifluquinazon) and B6 trifluoro-benzene pyrimidine (triflumezopyrrom);
the weight part ratio of the two active components of the component A, B is 1:10 to 10:1.
5. Use of a composition according to claim 1, characterized in that: the composition is used for preparing pesticide medicines for preventing and controlling pests on fruit trees, vegetables, ornamental plants, tea, cotton, cereal crops, shrubs, broad-leaved trees and evergreen trees or urban sanitary pests.
6. Use of a composition according to claim 1, characterized in that: the use of the composition for preventing or controlling lepidoptera, hemiptera, homoptera, coleoptera, diptera, thysanoptera, acarina pests and their larvae and eggs.
CN202211520879.3A 2022-11-29 2022-11-29 Synergistic compound binary composition of two active components and application thereof Pending CN118104672A (en)

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Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112457288A (en) * 2019-09-06 2021-03-09 沈阳中化农药化工研发有限公司 Piperine acid derivative and application thereof

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112457288A (en) * 2019-09-06 2021-03-09 沈阳中化农药化工研发有限公司 Piperine acid derivative and application thereof

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