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CN117530775B - Magnetic control intervention control method and system based on artificial intelligence and CT - Google Patents

Magnetic control intervention control method and system based on artificial intelligence and CT Download PDF

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CN117530775B
CN117530775B CN202410028563.5A CN202410028563A CN117530775B CN 117530775 B CN117530775 B CN 117530775B CN 202410028563 A CN202410028563 A CN 202410028563A CN 117530775 B CN117530775 B CN 117530775B
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张进祥
陈标
马冰清
蔡丞俊
吕新宇
程星
高翾
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Union Hospital Tongji Medical College Huazhong University of Science and Technology
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Abstract

The invention relates to the technical field of intelligent medical treatment, in particular to a magnetic control intervention control method and system based on artificial intelligence and CT, comprising the following steps: obtaining a blood vessel shape-changing calibration image through an artificial intelligent recognition model; obtaining a three-dimensional model of the blood vessel shape by a three-dimensional reconstruction technology; performing virtual construction of a digital twin platform by using a Gaussian-Kelvin projection method to obtain a blood vessel shape-shifting digital twin platform comprising a virtual magnetic intervention guide wire and a virtual blood vessel shape-shifting three-dimensional model; based on the vessel shape-moving digital twin platform, a virtual magnetic control intervention path of a virtual magnetic intervention guide wire is built in real time in a virtual vessel shape-moving three-dimensional model. The invention ensures that the virtual space and the physical space are synchronous in real time, the magnetic control intervention guide wire can obtain the intervention path update which is suitable for the real structure of the blood vessel in real time from the virtual space of the digital twin platform, and the planning of the intervention path and the magnetic control of the intervention running are separated, so that the mutual occupation of resources is avoided.

Description

一种基于人工智能和CT的磁控介入控制方法及系统A magnetic control intervention control method and system based on artificial intelligence and CT

技术领域Technical Field

本发明涉及智能医疗技术领域,具体涉及一种基于人工智能和CT的磁控介入控制方法。The present invention relates to the field of intelligent medical technology, and in particular to a magnetically controlled intervention control method based on artificial intelligence and CT.

背景技术Background technique

目前的医疗环境下,磁导航技术正越来越多的应用于医疗实践中。在现有的技术中,磁导航技术已被应用于介入手术。例如:在心脏介入手术中,磁导航技术能够实现在使用计算机界面控制磁场,并在DSA引导下进行穿刺导丝和导管的引导和定位,这种技术使得精细介入操作的精准性得到极大的提升,同时还可大大减少了患者和医务人员在手术过程中受到的辐射剂量。In the current medical environment, magnetic navigation technology is increasingly being used in medical practice. Among existing technologies, magnetic navigation technology has been applied to interventional surgery. For example, in cardiac interventional surgery, magnetic navigation technology can control the magnetic field using a computer interface, and guide and position the puncture guidewire and catheter under the guidance of DSA. This technology greatly improves the accuracy of delicate interventional operations, and can also greatly reduce the radiation dose received by patients and medical staff during surgery.

目前,现有的介入手术路径通常用一些简单的三维环境或者真实世界中不存在的虚拟环境来测试路径规划算法的效果,而真实环境中的血管形状结构是复杂多样的,在简单的三维环境或者真实世界不存在的虚拟环境中开发测试的路径规划算法难以满足磁性介入导丝的实际行进需求,影响介入治疗效果。此外,磁性导航仪的机载计算机的计算和存储资源是有限的,因此,磁性导航仪无法实时适应血管真实情况的变化,难以实现在边控制磁性介入导丝介入行进同时,边进行实时路径规划更新,相互资源的挤占,会影响磁控介入的精准性和安全性。At present, the existing interventional surgical paths usually use some simple three-dimensional environments or virtual environments that do not exist in the real world to test the effect of the path planning algorithm. However, the shape and structure of blood vessels in the real environment are complex and diverse. The path planning algorithm developed and tested in a simple three-dimensional environment or a virtual environment that does not exist in the real world is difficult to meet the actual travel requirements of the magnetic interventional guidewire, affecting the effect of interventional treatment. In addition, the computing and storage resources of the onboard computer of the magnetic navigator are limited. Therefore, the magnetic navigator cannot adapt to the changes in the actual situation of the blood vessels in real time. It is difficult to achieve real-time path planning updates while controlling the interventional travel of the magnetic interventional guidewire. The crowding out of each other's resources will affect the accuracy and safety of magnetic control intervention.

发明内容Summary of the invention

本发明的目的在于提供一种基于人工智能和CT的磁控介入控制方法及系统,以解决现有技术中尚未实现的由计算机全程控制磁控介入过程,实现在边控制磁性介入导丝介入行进同时,边进行实时路径规划更新,同时避免了计算机程序相互资源的挤占,影响磁控介入的精准性和安全性的技术问题。本发明不仅可以实现更加精准的介入手术操作,还能够极大减少介入医务人员的放射接触的技术效果。The purpose of the present invention is to provide a magnetic control intervention control method and system based on artificial intelligence and CT, so as to solve the problem that the magnetic control intervention process is fully controlled by a computer, which has not been realized in the prior art, and to realize real-time path planning and updating while controlling the magnetic intervention guide wire intervention, while avoiding the technical problem that the computer programs occupy each other's resources and affect the accuracy and safety of magnetic control intervention. The present invention can not only realize more accurate interventional surgical operations, but also greatly reduce the technical effect of radiation exposure of interventional medical personnel.

为解决上述技术问题,本发明具体提供下述技术方案:In order to solve the above technical problems, the present invention specifically provides the following technical solutions:

一种基于人工智能和CT的磁控介入控制方法,包括以下步骤:A magnetic control intervention control method based on artificial intelligence and CT, comprising the following steps:

获取血管造影CT图像;Acquire angiographic CT images;

血管走形的标定:通过人工智能识别模型,在血管造影CT图像中对表征血管的图像像素依据血管走形进行标定处理,得到血管走形标定图像;Calibration of blood vessel shape: Through the artificial intelligence recognition model, the image pixels representing the blood vessels in the angiography CT image are calibrated according to the blood vessel shape to obtain the blood vessel shape calibration image;

重建血管走形三维模型:通过三维重建技术,基于血管走形标定图像进行三维空间的物理重建,得到血管走形三维模型;Reconstructing the 3D model of blood vessel shape: Using the 3D reconstruction technology, the 3D space is physically reconstructed based on the vascular shape calibration image to obtain the 3D model of blood vessel shape;

构建血管走形数字孪生平台:利用高斯-克吕格投影法,依据磁性介入导丝和所述血管走形三维模型进行数字孪生平台的虚拟搭建,得到包含虚拟磁性介入导丝、虚拟血管走形三维模型的血管走形数字孪生平台;Constructing a digital twin platform for vascular shape: using the Gauss-Krüger projection method, a digital twin platform is virtually constructed based on the magnetic interventional guidewire and the vascular shape three-dimensional model, to obtain a vascular shape digital twin platform including a virtual magnetic interventional guidewire and a virtual vascular shape three-dimensional model;

基于血管走形数字孪生平台,利用DSA系统在虚拟血管走形三维模型中实时搭建虚拟磁性介入导丝的虚拟磁控介入路径;Based on the vascular shape digital twin platform, the DSA system is used to build a virtual magnetic intervention path of the virtual magnetic intervention guidewire in real time in the virtual vascular shape 3D model;

血管走形数字孪生平台将虚拟磁控介入路径实时反馈至磁导航仪器,由磁导航仪器实时控制磁性介入导丝依据虚拟磁控介入路径进行实时介入移动。The digital twin platform of vascular shape feeds back the virtual magnetically controlled interventional path to the magnetic navigation instrument in real time, and the magnetic navigation instrument controls the magnetic interventional guidewire in real time to perform real-time interventional movement according to the virtual magnetically controlled interventional path.

作为本发明的一种优选方案,对血管走形标定图像的标定方法包括:As a preferred solution of the present invention, a method for calibrating a blood vessel shape calibration image includes:

随机选取多个血管造影CT图像作为样本图像;A plurality of angiography CT images are randomly selected as sample images;

在样本图像中标记出表征血管的图像像素作为目标像素;Marking image pixels representing blood vessels in the sample image as target pixels;

将样本图像作为YOLO V3神经网络的输入项,将所述目标像素作为YOLO V3神经网络的输出项,利用YOLO V3神经网络对YOLO V3神经网络的输入项和YOLO V3神经网络的输出项进行映射学习,得到所述人工智能识别模型;Using the sample image as an input item of the YOLO V3 neural network, using the target pixel as an output item of the YOLO V3 neural network, and using the YOLO V3 neural network to perform mapping learning on the input item of the YOLO V3 neural network and the output item of the YOLO V3 neural network to obtain the artificial intelligence recognition model;

利用所述人工智能模型在每个血管造影CT图像中识别出表征血管的图像像素,并利用B样条曲线平滑法对表征血管的图像像素进行平滑链接,得到表征血管走形的标定线条;The artificial intelligence model is used to identify image pixels representing blood vessels in each angiography CT image, and the image pixels representing blood vessels are smoothly linked using a B-spline curve smoothing method to obtain calibration lines representing the shape of the blood vessels;

将具有所述标定线条的血管造影CT图像作为所述血管走形标定图像。The angiography CT image with the calibration lines is used as the blood vessel shape calibration image.

作为本发明的一种优选方案,对血管走形三维模型的重建是利用三维重建技术3DMax实现,并且利用三维重建技术3DMax在血管走形三维模型上标记出磁控介入起点和磁控介入终点。As a preferred solution of the present invention, the reconstruction of the three-dimensional model of the blood vessel shape is achieved using the three-dimensional reconstruction technology 3DMax, and the three-dimensional reconstruction technology 3DMax is used to mark the starting point and the end point of the magnetically controlled intervention on the three-dimensional model of the blood vessel shape.

作为本发明的一种优选方案,对血管走形数字孪生平台进行搭建的方法包括:As a preferred solution of the present invention, a method for building a blood vessel shape digital twin platform includes:

利用Unity3D开发数字孪生平台,并在数字孪生平台中加载显示所述磁性介入导丝、血管走形三维模型得到所述虚拟磁性介入导丝、虚拟血管走形三维模型;Developing a digital twin platform using Unity3D, and loading and displaying the magnetic interventional guidewire and the three-dimensional model of blood vessel shape in the digital twin platform to obtain the virtual magnetic interventional guidewire and the virtual three-dimensional model of blood vessel shape;

利用高斯-克吕格投影法将磁性介入导丝的物理坐标映射到数字孪生平台中虚拟磁性介入导丝的虚拟坐标上,将血管走形三维模型的物理坐标映射到数字孪生平台中虚拟血管走形三维模型的虚拟坐标上;The Gauss-Krüger projection method is used to map the physical coordinates of the magnetic interventional guidewire to the virtual coordinates of the virtual magnetic interventional guidewire in the digital twin platform, and the physical coordinates of the 3D model of vascular shape are mapped to the virtual coordinates of the 3D model of virtual vascular shape in the digital twin platform;

在磁性介入物理导丝和虚拟磁性介入导丝间建立用于数据交互的交互通道;An interactive channel for data interaction is established between the physical magnetic intervention guidewire and the virtual magnetic intervention guidewire;

搭建完成所述血管走形数字孪生平台。The blood vessel shape digital twin platform has been built.

作为本发明的一种优选方案,利用高斯-克吕格投影法对磁性介入导丝和血管走形三维模型的物理坐标进行坐标映射的方法包括:As a preferred solution of the present invention, a method for mapping the physical coordinates of the magnetic interventional guidewire and the three-dimensional model of the vascular shape by using the Gauss-Krüger projection method includes:

从血管走形三维模型中选取若干个第一控制点并记录其三维坐标,接着在真实环境中找到所选取的若干个第一控制点对应观测点的位置并记录其经纬度坐标,再将各所述观测点记录的包含高度信息的经纬度坐标通过高斯-克吕格投影正解公式投影转换为笛卡尔坐标系中的三维坐标;Selecting a plurality of first control points from the three-dimensional model of the blood vessel shape and recording their three-dimensional coordinates, then finding the positions of the observation points corresponding to the selected first control points in the real environment and recording their longitude and latitude coordinates, and then converting the longitude and latitude coordinates containing the height information recorded by each of the observation points into three-dimensional coordinates in the Cartesian coordinate system through the Gauss-Krüger projection forward solution formula;

根据若干个第一控制点的三维坐标与对应观测点经纬度坐标投影转换后的三维坐标,利用最小二乘法估计血管走形三维模型中心点从经纬度坐标投影转换到笛卡尔坐标系原点的坐标系偏差;According to the three-dimensional coordinates of the first control points and the three-dimensional coordinates after the projection transformation of the longitude and latitude coordinates of the corresponding observation points, the least square method is used to estimate the coordinate system deviation of the center point of the three-dimensional model of blood vessel shape from the projection transformation of the longitude and latitude coordinates to the origin of the Cartesian coordinate system;

血管走形三维模型所在的物理空间中每个模型点的经纬度坐标通过高斯-克吕格投影正解公式投影转换后的三维坐标与坐标系偏差相加后得到虚拟血管走形三维模型所在的虚拟空间中对应点在笛卡尔坐标系下的三维坐标;The latitude and longitude coordinates of each model point in the physical space where the three-dimensional model of blood vessel shape is located are projected and transformed by the Gauss-Krüger projection forward solution formula, and then the three-dimensional coordinates of the corresponding point in the virtual space where the three-dimensional model of virtual blood vessel shape is located are added to the coordinate system deviation to obtain the three-dimensional coordinates of the corresponding point in the virtual space where the three-dimensional model of virtual blood vessel shape is located in the Cartesian coordinate system;

通过虚拟血管走形三维模型所在的虚拟空间中每个模型点在笛卡尔坐标系下的三维坐标减去坐标系偏差后,再通过高斯-克吕格投影反解公式投影转换后得到血管走形三维模型所在的物理空间中对应点的经纬度坐标的数学关联,实现将血管走形三维模型的物理坐标映射至数字孪生平台中虚拟血管走形三维模型的虚拟坐标上;The three-dimensional coordinates of each model point in the virtual space where the virtual vascular shape three-dimensional model is located are deducted from the coordinate system deviation, and then the mathematical association of the longitude and latitude coordinates of the corresponding point in the physical space where the vascular shape three-dimensional model is located is obtained after projection transformation using the Gauss-Krüger projection inverse formula, so as to map the physical coordinates of the vascular shape three-dimensional model to the virtual coordinates of the virtual vascular shape three-dimensional model in the digital twin platform;

从磁性介入导丝中选取若干个第二控制点并记录其三维坐标,接着在真实环境中找到所选取的若干个第二控制点对应观测点的位置并记录其经纬度坐标,再将各所述观测点记录的包含高度信息的经纬度坐标通过高斯-克吕格投影正解公式投影转换为笛卡尔坐标系中的三维坐标;Selecting a number of second control points from the magnetic interventional guidewire and recording their three-dimensional coordinates, then finding the positions of the observation points corresponding to the selected second control points in the real environment and recording their longitude and latitude coordinates, and then converting the longitude and latitude coordinates containing the height information recorded at each observation point into three-dimensional coordinates in the Cartesian coordinate system through the Gauss-Krüger projection forward solution formula;

根据若干个第二控制点的三维坐标与对应观测点经纬度坐标投影转换后的三维坐标,利用最小二乘法估计磁性介入导丝中心点从经纬度坐标投影转换到笛卡尔坐标系原点的坐标系偏差;According to the three-dimensional coordinates of the plurality of second control points and the three-dimensional coordinates after the projection transformation of the longitude and latitude coordinates of the corresponding observation points, the coordinate system deviation of the center point of the magnetic interventional guide wire from the projection transformation of the longitude and latitude coordinates to the origin of the Cartesian coordinate system is estimated by using the least squares method;

磁性介入导丝所在的物理空间中每个模型点的经纬度坐标通过高斯-克吕格投影正解公式投影转换后的三维坐标与坐标系偏差相加后得到虚拟磁性介入导丝所在的虚拟空间中对应点在笛卡尔坐标系下的三维坐标;The latitude and longitude coordinates of each model point in the physical space where the magnetic interventional guidewire is located are projected and transformed by the Gauss-Krüger projection forward solution formula, and then the three-dimensional coordinates of the corresponding point in the virtual space where the virtual magnetic interventional guidewire is located are added to the coordinate system deviation to obtain the three-dimensional coordinates of the corresponding point in the Cartesian coordinate system;

通过磁性介入导丝所在的虚拟空间中每个模型点在笛卡尔坐标系下的三维坐标减去坐标系偏差后,再通过高斯-克吕格投影反解公式投影转换后得到磁性介入导丝所在的物理空间中对应点的经纬度坐标的数学关联,实现将磁性介入导丝的物理坐标映射至数字孪生平台中虚拟磁性介入导丝的虚拟坐标上。By subtracting the coordinate system deviation from the three-dimensional coordinates of each model point in the Cartesian coordinate system in the virtual space where the magnetic interventional guidewire is located, and then projecting and transforming through the Gauss-Krüger projection inverse formula, the mathematical association of the longitude and latitude coordinates of the corresponding point in the physical space where the magnetic interventional guidewire is located is obtained, thereby mapping the physical coordinates of the magnetic interventional guidewire to the virtual coordinates of the virtual magnetic interventional guidewire in the digital twin platform.

作为本发明的一种优选方案,对虚拟磁控介入路径进行实时搭建的方法包括:As a preferred solution of the present invention, a method for real-time construction of a virtual magnetic control intervention path includes:

血管走形数字孪生平台,基于虚拟血管走形三维模型,利用路径规划算法在磁控介入起点和磁控介入终点规划出磁控介入基础虚拟路径;The vascular shape digital twin platform, based on the virtual vascular shape 3D model, uses the path planning algorithm to plan the basic virtual path of magnetically controlled intervention at the starting point and end point of magnetically controlled intervention;

血管走形数字孪生平台将磁控介入基础虚拟路径通过交互通道实时反馈至磁导航仪器,由磁导航仪器实时控制磁性介入导丝依据磁控介入基础虚拟路径进行实时介入移动;The blood vessel shape digital twin platform feeds back the magnetic control intervention basic virtual path to the magnetic navigation instrument in real time through the interactive channel, and the magnetic navigation instrument controls the magnetic intervention guide wire to perform real-time intervention movement according to the magnetic control intervention basic virtual path.

通过DSA系统,在磁控介入导丝沿磁控介入基础虚拟路径进行实时介入移动过程中,获取磁控介入导丝的实时物理坐标,并获取磁控介入导丝所处实时物理坐标处的实时DSA图像,同时将实时DSA图像和实时物理坐标通过交互通道传输至血管走形数字孪生平台;Through the DSA system, when the magnetically controlled interventional guidewire is moving in real time along the magnetically controlled interventional basic virtual path, the real-time physical coordinates of the magnetically controlled interventional guidewire are obtained, and the real-time DSA image at the real-time physical coordinates of the magnetically controlled interventional guidewire is obtained. At the same time, the real-time DSA image and the real-time physical coordinates are transmitted to the vascular shape digital twin platform through the interactive channel.

血管走形数字孪生平台根据实时物理坐标,在所述虚拟血管走形三维模型中,获取实时物理坐标对应的虚拟坐标处的血管造影CT图像,标记为先验CT图像;The blood vessel shape digital twin platform obtains, according to the real-time physical coordinates, in the virtual blood vessel shape three-dimensional model, an angiography CT image at the virtual coordinates corresponding to the real-time physical coordinates, and marks it as a priori CT image;

血管走形数字孪生平台利用孪生神经网络,基于实时DSA图像以及先验CT图像进行路径规划适用性实时检测,得到路径规划适用性;The blood vessel shape digital twin platform uses twin neural networks to perform real-time detection of path planning suitability based on real-time DSA images and prior CT images to obtain path planning suitability;

血管走形数字孪生平台根据路径规划适用性,在虚拟血管走形三维模型进行更新位点的识别,得到虚拟血管走形三维模型中的更新位点;The blood vessel shape digital twin platform identifies the update location in the virtual blood vessel shape three-dimensional model according to the path planning applicability, and obtains the update location in the virtual blood vessel shape three-dimensional model;

在虚拟血管走形三维模型中的更新位点处,利用所述更新位点处对应的实时DSA图像对虚拟血管走形三维模型进行更新;At an update position in the virtual vascular shape three-dimensional model, the virtual vascular shape three-dimensional model is updated using a real-time DSA image corresponding to the update position;

血管走形数字孪生平台,基于更新后的虚拟血管走形三维模型,利用路径规划算法在更新位点和磁控介入终点规划出磁控介入更新虚拟路径;The vascular shape digital twin platform plans a virtual path for magnetically controlled intervention update at the update site and the end point of magnetically controlled intervention based on the updated virtual vascular shape 3D model using a path planning algorithm.

血管走形数字孪生平台将磁控介入更新虚拟路径通过交互通道实时反馈至磁导航仪器,由磁导航仪器实时控制磁性介入导丝依据磁控介入更新虚拟路径进行实时介入移动。The digital twin platform for vascular shape will feed back the updated virtual path of magnetically controlled intervention to the magnetic navigation instrument through the interactive channel in real time. The magnetic navigation instrument will then control the magnetic intervention guidewire to perform real-time intervention movement based on the updated virtual path of magnetically controlled intervention.

作为本发明的一种优选方案,对路径规划适用性的检测方法包括:As a preferred solution of the present invention, a method for detecting the applicability of path planning includes:

将所述实时DSA图像输入至孪生神经网络中第一个CNN网络结构中,由孪生神经网络中第一个CNN网络结构输出实时DSA图像中的血管特征;Inputting the real-time DSA image into the first CNN network structure in the twin neural network, and outputting the vascular features in the real-time DSA image by the first CNN network structure in the twin neural network;

将所述实时CT图像输入至孪生神经网络中第二个CNN网络结构中,由孪生神经网络中第二个CNN网络结构输出先验CT图像中的血管特征;Inputting the real-time CT image into the second CNN network structure in the twin neural network, and the second CNN network structure in the twin neural network outputs the vascular features in the prior CT image;

利用孪生神经网络的损失函数对路径规划适用性检测,所述路径规划适用性的表达式为:Match_goal=-(1-Loss)rlog(Loss);式中,Match_goal为路径规划适用性,Loss为孪生神经网络的损失函数,r为人工调控参数;The loss function of the twin neural network is used to detect the suitability of the path planning. The expression of the path planning suitability is: Match_goal=-(1-Loss) r log(Loss); where Match_goal is the suitability of the path planning, Loss is the loss function of the twin neural network, and r is the manual control parameter;

所述人工调控参数用于在虚拟血管走形三维模型的更新中加入人为意志;The artificial control parameters are used to add human will into the updating of the virtual vascular shape three-dimensional model;

其中,所述孪生神经网络的损失函数为:Loss=MSE(out1,out2);式中,Loss为损失函数,out1为孪生神经网络中第一个CNN网络结构的输出,out2为孪生神经网络中第二个CNN网络结构的输出,MSE为均方误差函数体,MSE(out1,out2)为out1和out2间的均方误差。Among them, the loss function of the twin neural network is: Loss=MSE(out1,out2); where Loss is the loss function, out1 is the output of the first CNN network structure in the twin neural network, out2 is the output of the second CNN network structure in the twin neural network, MSE is the mean square error function, and MSE(out1,out2) is the mean square error between out1 and out2.

作为本发明的一种优选方案,对虚拟血管走形三维模型中更新位点的识别方法包括:As a preferred solution of the present invention, a method for identifying update positions in a virtual vascular shape three-dimensional model includes:

将所述路径规划适用性与预设阈值进行比较,其中,The path planning suitability is compared with a preset threshold, wherein:

当所述路径规划适用性大于或等于预设阈值,则将先验CT图像对应的虚拟坐标标定为虚拟血管走形三维模型中更新位点;When the path planning applicability is greater than or equal to a preset threshold, the virtual coordinates corresponding to the prior CT image are calibrated as update positions in the virtual vascular shape three-dimensional model;

当所述路径规划适用性小于预设阈值,则将先验CT图像对应的虚拟坐标标定为虚拟血管走形三维模型中非更新位点。When the path planning applicability is less than a preset threshold, the virtual coordinates corresponding to the prior CT image are calibrated as non-updated locations in the virtual vascular shape three-dimensional model.

作为本发明的一种优选方案,利用所述更新位点处对应的实时DSA图像对虚拟血管走形三维模型的更新方法,包括:As a preferred solution of the present invention, a method for updating the virtual vascular shape three-dimensional model using the real-time DSA image corresponding to the update site includes:

将更新位点处对应的实时DSA图像的血管特征,替换虚拟血管走形三维模型中更新位点处对应的先验CT图像的血管特征,得到更新后的虚拟血管走形三维模型。The vascular features of the real-time DSA image corresponding to the updated position are used to replace the vascular features of the priori CT image corresponding to the updated position in the virtual vascular shape three-dimensional model to obtain an updated virtual vascular shape three-dimensional model.

作为本发明的一种优选方案,本发明提供了一种基于人工智能和CT的磁控介入控制系统,应用于所述的一种基于人工智能和CT的磁控介入控制方法,磁控介入控制系统包括:As a preferred solution of the present invention, the present invention provides a magnetic control intervention control system based on artificial intelligence and CT, which is applied to the magnetic control intervention control method based on artificial intelligence and CT. The magnetic control intervention control system includes:

图像采集单元,用于获取血管造影CT图像、DSA图像;An image acquisition unit, used for acquiring angiography CT images and DSA images;

图像处理单元,用于通过人工智能识别模型,在血管造影CT图像中对表征血管的图像像素依据血管走形进行标定处理,得到血管走形标定图像;An image processing unit is used to calibrate the image pixels representing the blood vessels in the angiography CT image according to the shape of the blood vessels through an artificial intelligence recognition model to obtain a calibrated image of the blood vessel shape;

三维重建单元,用于通过三维重建技术,基于血管走形标定图像进行三维空间的物理重建,得到血管走形三维模型;A three-dimensional reconstruction unit, used to perform physical reconstruction of the three-dimensional space based on the vascular shape calibration image by using the three-dimensional reconstruction technology to obtain a three-dimensional model of the vascular shape;

平台搭建单元,用于利用高斯-克吕格投影法,依据磁性介入导丝、血管走形三维模型进行数字孪生平台的虚拟搭建,得到包含虚拟磁性介入导丝、虚拟血管走形三维模型的血管走形数字孪生平台;The platform building unit is used to virtually build a digital twin platform based on the magnetic intervention guidewire and the three-dimensional model of the blood vessel shape by using the Gauss-Krüger projection method, so as to obtain a blood vessel shape digital twin platform including a virtual magnetic intervention guidewire and a virtual three-dimensional model of the blood vessel shape;

平台运行单元,连接DSA系统,用于基于血管走形数字孪生平台,利用DSA系统在虚拟血管走形三维模型中实时搭建虚拟磁性介入导丝的虚拟磁控介入路径;The platform operation unit is connected to the DSA system and is used to build a virtual magnetic intervention path of a virtual magnetic intervention guidewire in real time in a virtual vascular shape three-dimensional model based on the vascular shape digital twin platform using the DSA system;

磁控介入单元,包含磁导航仪器,用于接收血管走形数字孪生平台反馈的虚拟磁控介入路径,并实时控制磁性介入导丝依据虚拟磁控介入路径进行实时介入移动;The magnetically controlled intervention unit includes a magnetic navigation instrument, which is used to receive the virtual magnetically controlled intervention path fed back by the vascular shape digital twin platform, and to control the magnetic intervention guidewire to perform real-time intervention movement according to the virtual magnetically controlled intervention path;

其中,所述平台运行单元利用DSA系统在虚拟血管走形三维模型中实时搭建虚拟磁性介入导丝的虚拟磁控介入路径,包括:The platform operation unit uses the DSA system to build a virtual magnetic intervention path of a virtual magnetic intervention guidewire in real time in a virtual vascular shape three-dimensional model, including:

血管走形数字孪生平台,基于虚拟血管走形三维模型,利用路径规划算法在磁控介入起点和磁控介入终点规划出磁控介入基础虚拟路径;The vascular shape digital twin platform, based on the virtual vascular shape 3D model, uses the path planning algorithm to plan the basic virtual path of magnetically controlled intervention at the starting point and end point of magnetically controlled intervention;

血管走形数字孪生平台将磁控介入基础虚拟路径通过交互通道实时反馈至磁导航仪器,由磁导航仪器实时控制磁性介入导丝依据磁控介入基础虚拟路径进行实时介入移动;The blood vessel shape digital twin platform feeds back the magnetic control intervention basic virtual path to the magnetic navigation instrument in real time through the interactive channel, and the magnetic navigation instrument controls the magnetic intervention guide wire to perform real-time intervention movement according to the magnetic control intervention basic virtual path.

通过DSA系统,在磁控介入导丝沿磁控介入基础虚拟路径进行实时介入移动过程中,获取磁控介入导丝的实时物理坐标,并获取磁控介入导丝所处实时物理坐标处的实时DSA图像,同时将实时DSA图像和实时物理坐标通过交互通道传输至血管走形数字孪生平台;Through the DSA system, when the magnetically controlled interventional guidewire is moving in real time along the magnetically controlled interventional basic virtual path, the real-time physical coordinates of the magnetically controlled interventional guidewire are obtained, and the real-time DSA image at the real-time physical coordinates of the magnetically controlled interventional guidewire is obtained. At the same time, the real-time DSA image and the real-time physical coordinates are transmitted to the vascular shape digital twin platform through the interactive channel.

血管走形数字孪生平台根据实时物理坐标,在所述虚拟血管走形三维模型中,获取实时物理坐标对应的虚拟坐标处的血管造影CT图像,标记为先验CT图像;The blood vessel shape digital twin platform obtains, according to the real-time physical coordinates, in the virtual blood vessel shape three-dimensional model, an angiography CT image at the virtual coordinates corresponding to the real-time physical coordinates, and marks it as a priori CT image;

血管走形数字孪生平台利用孪生神经网络,基于实时DSA图像以及先验CT图像进行路径规划适用性实时检测,得到路径规划适用性;The blood vessel shape digital twin platform uses twin neural networks to perform real-time detection of path planning suitability based on real-time DSA images and prior CT images to obtain path planning suitability;

血管走形数字孪生平台根据路径规划适用性,在虚拟血管走形三维模型进行更新位点的识别,得到虚拟血管走形三维模型中的更新位点;The blood vessel shape digital twin platform identifies the update location in the virtual blood vessel shape three-dimensional model according to the path planning applicability, and obtains the update location in the virtual blood vessel shape three-dimensional model;

在虚拟血管走形三维模型中的更新位点处,利用所述更新位点处对应的实时DSA图像对虚拟血管走形三维模型进行更新;At an update position in the virtual vascular shape three-dimensional model, the virtual vascular shape three-dimensional model is updated using a real-time DSA image corresponding to the update position;

血管走形数字孪生平台,基于更新后的虚拟血管走形三维模型,利用路径规划算法在更新位点和磁控介入终点规划出磁控介入更新虚拟路径;The vascular shape digital twin platform plans a virtual path for magnetically controlled intervention update at the update site and the end point of magnetically controlled intervention based on the updated virtual vascular shape 3D model using a path planning algorithm.

血管走形数字孪生平台将磁控介入更新虚拟路径通过交互通道实时反馈至磁导航仪器,由磁导航仪器实时控制磁性介入导丝依据磁控介入更新虚拟路径进行实时介入移动。The digital twin platform for vascular shape will feed back the updated virtual path of magnetically controlled intervention to the magnetic navigation instrument through the interactive channel in real time. The magnetic navigation instrument will then control the magnetic intervention guidewire to perform real-time intervention movement based on the updated virtual path of magnetically controlled intervention.

本发明与现有技术相比较具有如下有益效果:Compared with the prior art, the present invention has the following beneficial effects:

本发明依据磁性介入导丝、血管走形三维模型进行数字孪生平台的虚拟搭建,得到包含虚拟磁性介入导丝、虚拟血管走形三维模型的血管走形数字孪生平台,使得磁控介入路径规划在开发测试阶段可以在贴近真实环境的虚拟空间中进行大量的测试,有效提升磁控介入导丝在真实环境中介入运动时的安全性,而且虚拟空间和物理空间的实时同步,让磁控介入导丝能够实时地从数字孪生平台的虚拟空间中获得实时适应血管真实结构的介入路径更新,将介入路径的规划和介入行进的磁控分开,避免相互挤占资源,有效减轻磁控导航仪机载计算机压力的同时也能提高磁控介入行进的效率,保障介入路径的规划准确性和安全性。The present invention virtually constructs a digital twin platform based on a magnetic interventional guidewire and a three-dimensional model of vascular shape, and obtains a vascular shape digital twin platform including a virtual magnetic interventional guidewire and a virtual three-dimensional model of vascular shape, so that a large number of tests can be carried out on the magnetically controlled interventional path planning in a virtual space close to the real environment during the development and testing phase, thereby effectively improving the safety of the magnetically controlled interventional guidewire during interventional movement in a real environment. Moreover, the real-time synchronization of the virtual space and the physical space enables the magnetically controlled interventional guidewire to obtain real-time interventional path updates that adapt to the real structure of the blood vessel from the virtual space of the digital twin platform in real time, separates the planning of the interventional path from the magnetic control of the interventional movement, avoids mutual crowding out of resources, effectively reduces the pressure on the onboard computer of the magnetically controlled navigator, and can also improve the efficiency of the magnetically controlled interventional movement, thereby ensuring the accuracy and safety of the planning of the interventional path.

附图说明BRIEF DESCRIPTION OF THE DRAWINGS

为了更清楚地说明本发明的实施方式或现有技术中的技术方案,下面将对实施方式或现有技术描述中所需要使用的附图作简单地介绍。显而易见地,下面描述中的附图仅仅是示例性的,对于本领域普通技术人员来讲,在不付出创造性劳动的前提下,还可以根据提供的附图引伸获得其它的实施附图。In order to more clearly illustrate the implementation of the present invention or the technical solution in the prior art, the following briefly introduces the drawings required for the implementation or the prior art description. Obviously, the drawings in the following description are only exemplary, and for ordinary technicians in this field, other implementation drawings can be derived from the provided drawings without creative work.

图1为本发明实施例提供的基于人工智能和CT的磁控介入控制方法流程图;FIG1 is a flow chart of a magnetic control intervention control method based on artificial intelligence and CT provided by an embodiment of the present invention;

图2为本发明实施例提供的控制系统框图;FIG2 is a block diagram of a control system provided by an embodiment of the present invention;

图3为本发明实施例提供的血管走形标定图像。FIG. 3 is a blood vessel shape calibration image provided by an embodiment of the present invention.

具体实施方式Detailed ways

下面将结合本发明实施例中的附图,对本发明实施例中的技术方案进行清楚、完整地描述,显然,所描述的实施例仅仅是本发明一部分实施例,而不是全部的实施例。基于本发明中的实施例,本领域普通技术人员在没有做出创造性劳动前提下所获得的所有其他实施例,都属于本发明保护的范围。The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

如图1所示,本发明提供了一种基于人工智能和CT的磁控介入控制方法,包括以下步骤:获取血管造影CT图像;As shown in FIG1 , the present invention provides a magnetic control intervention control method based on artificial intelligence and CT, comprising the following steps: acquiring angiographic CT images;

血管走形的标定:通过人工智能识别模型,在血管造影CT图像中对表征血管的图像像素依据血管走形进行标定处理,得到血管走形标定图像;Calibration of blood vessel shape: Through the artificial intelligence recognition model, the image pixels representing the blood vessels in the angiography CT image are calibrated according to the blood vessel shape to obtain the blood vessel shape calibration image;

重建血管走形三维模型:通过三维重建技术,基于血管走形标定图像进行三维空间的物理重建,得到血管走形三维模型;Reconstructing the 3D model of blood vessel shape: Using the 3D reconstruction technology, the 3D space is physically reconstructed based on the vascular shape calibration image to obtain the 3D model of blood vessel shape;

构建血管走形数字孪生平台:利用高斯-克吕格投影法,依据磁性介入导丝和血管走形三维模型进行数字孪生平台的虚拟搭建,得到包含虚拟磁性介入导丝、虚拟血管走形三维模型的血管走形数字孪生平台;Constructing a digital twin platform for vascular shape: Using the Gauss-Krüger projection method, a digital twin platform is virtually constructed based on the magnetic interventional guidewire and the vascular shape three-dimensional model, and a vascular shape digital twin platform including a virtual magnetic interventional guidewire and a virtual vascular shape three-dimensional model is obtained;

基于血管走形数字孪生平台,利用DSA系统在虚拟血管走形三维模型中实时搭建虚拟磁性介入导丝的虚拟磁控介入路径;Based on the vascular shape digital twin platform, the DSA system is used to build a virtual magnetic intervention path of the virtual magnetic intervention guidewire in real time in the virtual vascular shape 3D model;

血管走形数字孪生平台将虚拟磁控介入路径实时反馈至磁导航仪器,由磁导航仪器实时控制磁性介入导丝依据虚拟磁控介入路径进行实时介入移动。The digital twin platform of vascular shape feeds back the virtual magnetically controlled interventional path to the magnetic navigation instrument in real time, and the magnetic navigation instrument controls the magnetic interventional guidewire in real time to perform real-time interventional movement according to the virtual magnetically controlled interventional path.

本发明为了避免磁控介入控制方法中,介入路径的规划和介入行进的磁控这两个过程发生资源挤占,利用数字孪生技术搭建数字孪生平台进行介入路径的规划,使得磁控导航仪只需要依据数字孪生平台规划出的介入路径进行介入行进的磁控,有效减轻磁控导航仪机载计算机压力的同时也能提高磁控介入行进的效率。In order to avoid resource crowding out in the two processes of intervention path planning and interventional magnetic control in the magnetic control intervention control method, the present invention uses digital twin technology to build a digital twin platform to plan the intervention path, so that the magnetic control navigator only needs to perform magnetic control of the interventional movement according to the intervention path planned by the digital twin platform, which effectively reduces the pressure on the onboard computer of the magnetic control navigator and can also improve the efficiency of magnetic control intervention.

具体的,利用数字孪生平台进行介入路径的规划,使得磁控介入路径规划在开发测试阶段可以在贴近真实环境的虚拟空间中进行大量的测试,有效提升磁控介入导丝在真实环境中介入行进运动时的安全性。Specifically, the use of the digital twin platform for interventional path planning allows for a large number of tests to be conducted in a virtual space close to the real environment during the development and testing phase of the magnetically controlled interventional path planning, effectively improving the safety of the magnetically controlled interventional guidewire during interventional movement in a real environment.

进一步的,数字孪生平台的虚拟空间中血管虚拟模型与真实介入场景之间进行数据交互,交互呈现实时交互,数字孪生平台根据实时交互的信息,进行血管虚拟模型的自适应更新,从而实现介入路径的自适应更新,保障了介入发生过程中,介入路径根据真实血管形状、结构进行适应性匹配,实现介入路径的修正更新,提高了磁控介入的准确性。Furthermore, data is exchanged between the virtual model of blood vessels and the real intervention scene in the virtual space of the digital twin platform, and the interaction is presented in real time. The digital twin platform adaptively updates the virtual model of blood vessels based on the information of real-time interaction, thereby realizing adaptive update of the intervention path, ensuring that during the intervention process, the intervention path is adaptively matched according to the real blood vessel shape and structure, realizing the correction and update of the intervention path, and improving the accuracy of magnetic control intervention.

本发明为了构建规划介入路径的数字孪生平台,利用神经网络训练一个可以识别CT造影后血管走形的人工智能模型,实现造影后的血管识别精准化,为数字孪生平台介入路径规划提供数据基础,进一步保障了数字孪生平台介入路径规划对真实场景的适配性,即提高介入路径规划的准确性,具体如下:In order to build a digital twin platform for planning interventional pathways, the present invention uses a neural network to train an artificial intelligence model that can identify the shape of blood vessels after CT angiography, realizes accurate recognition of blood vessels after angiography, provides a data basis for interventional pathway planning on the digital twin platform, and further ensures the adaptability of interventional pathway planning on the digital twin platform to real scenarios, that is, improves the accuracy of interventional pathway planning, as follows:

如图3所示,对血管走形标定图像的标定方法包括:As shown in FIG3 , the calibration method for the blood vessel shape calibration image includes:

随机选取多个血管造影CT图像作为样本图像;A plurality of angiography CT images are randomly selected as sample images;

在样本图像中标记出表征血管的图像像素作为目标像素;Marking image pixels representing blood vessels in the sample image as target pixels;

将样本图像作为YOLO V3神经网络的输入项,将目标像素作为YOLO V3神经网络的输出项,利用YOLO V3神经网络对YOLO V3神经网络的输入项和YOLO V3神经网络的输出项进行映射学习,得到人工智能识别模型;The sample image is used as the input of the YOLO V3 neural network, the target pixel is used as the output of the YOLO V3 neural network, and the YOLO V3 neural network is used to map the input of the YOLO V3 neural network and the output of the YOLO V3 neural network to obtain an artificial intelligence recognition model;

利用人工智能模型在每个血管造影CT图像中识别出表征血管的图像像素,并利用B样条曲线平滑法对表征血管的图像像素进行平滑链接,得到表征血管走形的标定线条;The artificial intelligence model is used to identify the image pixels representing the blood vessels in each angiography CT image, and the image pixels representing the blood vessels are smoothly linked using the B-spline curve smoothing method to obtain the calibration lines representing the shape of the blood vessels;

将具有标定线条的血管造影CT图像作为血管走形标定图像,图3中黑色线条为血管走形。The angiography CT image with calibration lines is used as the vessel shape calibration image. The black lines in FIG3 represent the vessel shape.

本发明利用数字孪生技术搭建数字孪生平台,具体如下:The present invention uses digital twin technology to build a digital twin platform, as follows:

对血管走形三维模型的重建是利用三维重建技术3DMax实现,并且利用三维重建技术3DMax在血管走形三维模型上标记出磁控介入起点和磁控介入终点。The reconstruction of the three-dimensional model of the blood vessel shape is achieved by using the three-dimensional reconstruction technology 3DMax, and the three-dimensional reconstruction technology 3DMax is used to mark the starting point and the end point of the magnetically controlled intervention on the three-dimensional model of the blood vessel shape.

对血管走形数字孪生平台进行搭建的方法包括:Methods for building a digital twin platform for vascular shape include:

利用Unity3D开发数字孪生平台,并在数字孪生平台中加载显示磁性介入导丝、血管走形三维模型得到虚拟磁性介入导丝、虚拟血管走形三维模型;Use Unity3D to develop a digital twin platform, and load and display the magnetic interventional guidewire and the 3D model of blood vessel shape in the digital twin platform to obtain a virtual magnetic interventional guidewire and a virtual 3D model of blood vessel shape;

利用高斯-克吕格投影法将磁性介入导丝的物理坐标映射到数字孪生平台中虚拟磁性介入导丝的虚拟坐标上,将血管走形三维模型的物理坐标映射到数字孪生平台中虚拟血管走形三维模型的虚拟坐标上;The Gauss-Krüger projection method is used to map the physical coordinates of the magnetic interventional guidewire to the virtual coordinates of the virtual magnetic interventional guidewire in the digital twin platform, and the physical coordinates of the 3D model of vascular shape are mapped to the virtual coordinates of the 3D model of virtual vascular shape in the digital twin platform;

在磁性介入物理导丝和虚拟磁性介入导丝间建立用于数据交互的交互通道;An interactive channel for data interaction is established between the physical magnetic intervention guidewire and the virtual magnetic intervention guidewire;

搭建完成血管走形数字孪生平台。The digital twin platform for blood vessel shape has been completed.

利用高斯-克吕格投影法对磁性介入导丝和血管走形三维模型的物理坐标进行坐标映射的方法包括:The method of using the Gauss-Krüger projection method to coordinate map the physical coordinates of the magnetic interventional guidewire and the three-dimensional model of the vascular shape includes:

从血管走形三维模型中选取若干个第一控制点并记录其三维坐标,接着在真实环境中找到所选取的若干个第一控制点对应观测点的位置并记录其经纬度坐标,再将各观测点记录的包含高度信息的经纬度坐标通过高斯-克吕格投影正解公式投影转换为笛卡尔坐标系中的三维坐标;Selecting a number of first control points from the three-dimensional model of the blood vessel shape and recording their three-dimensional coordinates, then finding the positions of the observation points corresponding to the selected first control points in the real environment and recording their longitude and latitude coordinates, and then converting the longitude and latitude coordinates containing height information recorded at each observation point into three-dimensional coordinates in the Cartesian coordinate system through the Gauss-Krüger projection forward solution formula;

根据若干个第一控制点的三维坐标与对应观测点经纬度坐标投影转换后的三维坐标,利用最小二乘法估计血管走形三维模型中心点从经纬度坐标投影转换到笛卡尔坐标系原点的坐标系偏差;According to the three-dimensional coordinates of the first control points and the three-dimensional coordinates after the projection transformation of the longitude and latitude coordinates of the corresponding observation points, the least square method is used to estimate the coordinate system deviation of the center point of the three-dimensional model of blood vessel shape from the projection transformation of the longitude and latitude coordinates to the origin of the Cartesian coordinate system;

血管走形三维模型所在的物理空间中每个模型点的经纬度坐标通过高斯-克吕格投影正解公式投影转换后的三维坐标与坐标系偏差相加后得到虚拟血管走形三维模型所在的虚拟空间中对应点在笛卡尔坐标系下的三维坐标;The latitude and longitude coordinates of each model point in the physical space where the three-dimensional model of blood vessel shape is located are projected and transformed by the Gauss-Krüger projection forward solution formula, and then the three-dimensional coordinates of the corresponding point in the virtual space where the three-dimensional model of virtual blood vessel shape is located are added to the coordinate system deviation to obtain the three-dimensional coordinates of the corresponding point in the virtual space where the three-dimensional model of virtual blood vessel shape is located in the Cartesian coordinate system;

通过虚拟血管走形三维模型所在的虚拟空间中每个模型点在笛卡尔坐标系下的三维坐标减去坐标系偏差后,再通过高斯-克吕格投影反解公式投影转换后得到血管走形三维模型所在的物理空间中对应点的经纬度坐标的数学关联,实现将血管走形三维模型的物理坐标映射至数字孪生平台中虚拟血管走形三维模型的虚拟坐标上;The three-dimensional coordinates of each model point in the virtual space where the virtual vascular shape three-dimensional model is located are deducted from the coordinate system deviation, and then the mathematical association of the longitude and latitude coordinates of the corresponding point in the physical space where the vascular shape three-dimensional model is located is obtained after projection transformation using the Gauss-Krüger projection inverse formula, so as to map the physical coordinates of the vascular shape three-dimensional model to the virtual coordinates of the virtual vascular shape three-dimensional model in the digital twin platform;

从磁性介入导丝中选取若干个第二控制点并记录其三维坐标,接着在真实环境中找到所选取的若干个第二控制点对应观测点的位置并记录其经纬度坐标,再将各观测点记录的包含高度信息的经纬度坐标通过高斯-克吕格投影正解公式投影转换为笛卡尔坐标系中的三维坐标;Select a number of second control points from the magnetic interventional guidewire and record their three-dimensional coordinates, then find the positions of the observation points corresponding to the selected second control points in the real environment and record their longitude and latitude coordinates, and then convert the longitude and latitude coordinates containing height information recorded at each observation point into three-dimensional coordinates in the Cartesian coordinate system through the Gauss-Krüger projection forward solution formula;

根据若干个第二控制点的三维坐标与对应观测点经纬度坐标投影转换后的三维坐标,利用最小二乘法估计磁性介入导丝中心点从经纬度坐标投影转换到笛卡尔坐标系原点的坐标系偏差;According to the three-dimensional coordinates of the plurality of second control points and the three-dimensional coordinates after the projection transformation of the longitude and latitude coordinates of the corresponding observation points, the coordinate system deviation of the center point of the magnetic interventional guide wire from the projection transformation of the longitude and latitude coordinates to the origin of the Cartesian coordinate system is estimated by using the least squares method;

磁性介入导丝所在的物理空间中每个模型点的经纬度坐标通过高斯-克吕格投影正解公式投影转换后的三维坐标与坐标系偏差相加后得到虚拟磁性介入导丝所在的虚拟空间中对应点在笛卡尔坐标系下的三维坐标;The latitude and longitude coordinates of each model point in the physical space where the magnetic interventional guidewire is located are projected and transformed by the Gauss-Krüger projection forward solution formula, and then the three-dimensional coordinates of the corresponding point in the virtual space where the virtual magnetic interventional guidewire is located are added to the coordinate system deviation to obtain the three-dimensional coordinates of the corresponding point in the Cartesian coordinate system;

通过磁性介入导丝所在的虚拟空间中每个模型点在笛卡尔坐标系下的三维坐标减去坐标系偏差后,再通过高斯-克吕格投影反解公式投影转换后得到磁性介入导丝所在的物理空间中对应点的经纬度坐标的数学关联,实现将磁性介入导丝的物理坐标映射至数字孪生平台中虚拟磁性介入导丝的虚拟坐标上。By subtracting the coordinate system deviation from the three-dimensional coordinates of each model point in the Cartesian coordinate system in the virtual space where the magnetic interventional guidewire is located, and then projecting and transforming through the Gauss-Krüger projection inverse formula, the mathematical association of the longitude and latitude coordinates of the corresponding point in the physical space where the magnetic interventional guidewire is located is obtained, thereby mapping the physical coordinates of the magnetic interventional guidewire to the virtual coordinates of the virtual magnetic interventional guidewire in the digital twin platform.

本发明高斯-克吕格投影法使得数字孪生平台上的虚拟血管走形三维模型,从形状和坐标上进行同步,从而便于数字孪生平台与介入真实场景间数据交互,即实现虚拟空间和真实空间的同步映射,从而能够保障数字孪生平台上能够根据血管真实情况进行适应性修正,保障介入路径规划的准确性。The Gauss-Krüger projection method of the present invention synchronizes the virtual vascular shape three-dimensional model on the digital twin platform in terms of shape and coordinates, thereby facilitating data interaction between the digital twin platform and the real intervention scene, that is, realizing the synchronous mapping of virtual space and real space, thereby ensuring that the digital twin platform can perform adaptive corrections based on the actual situation of the blood vessels and ensure the accuracy of intervention path planning.

本发明中数字孪生平台的虚拟空间中血管虚拟模型与真实介入场景之间进行数据交互,交互呈现实时交互,数字孪生平台根据实时交互的信息,进行血管虚拟模型的自适应更新,从而实现介入路径的自适应更新,具体如下:In the present invention, data is exchanged between the vascular virtual model and the real intervention scene in the virtual space of the digital twin platform, and the interaction is presented in real time. The digital twin platform adaptively updates the vascular virtual model based on the information of the real-time interaction, thereby realizing the adaptive update of the intervention path, as follows:

对虚拟磁控介入路径进行实时搭建的方法包括:The method for real-time construction of a virtual magnetic control intervention path includes:

血管走形数字孪生平台,基于虚拟血管走形三维模型,利用路径规划算法在磁控介入起点和磁控介入终点规划出磁控介入基础虚拟路径;The vascular shape digital twin platform, based on the virtual vascular shape 3D model, uses the path planning algorithm to plan the basic virtual path of magnetically controlled intervention at the starting point and end point of magnetically controlled intervention;

血管走形数字孪生平台将磁控介入基础虚拟路径通过交互通道实时反馈至磁导航仪器,由磁导航仪器实时控制磁性介入导丝依据磁控介入基础虚拟路径进行实时介入移动;The blood vessel shape digital twin platform feeds back the magnetic control intervention basic virtual path to the magnetic navigation instrument in real time through the interactive channel, and the magnetic navigation instrument controls the magnetic intervention guide wire to perform real-time intervention movement according to the magnetic control intervention basic virtual path.

通过DSA系统,在磁控介入导丝沿磁控介入基础虚拟路径进行实时介入移动过程中,获取磁控介入导丝的实时物理坐标,并获取磁控介入导丝所处实时物理坐标处的实时DSA图像,同时将实时DSA图像和实时物理坐标通过交互通道传输至血管走形数字孪生平台;Through the DSA system, when the magnetically controlled interventional guidewire is moving in real time along the magnetically controlled interventional basic virtual path, the real-time physical coordinates of the magnetically controlled interventional guidewire are obtained, and the real-time DSA image at the real-time physical coordinates of the magnetically controlled interventional guidewire is obtained. At the same time, the real-time DSA image and the real-time physical coordinates are transmitted to the vascular shape digital twin platform through the interactive channel.

血管走形数字孪生平台根据实时物理坐标,在虚拟血管走形三维模型中,获取实时物理坐标对应的虚拟坐标处的血管造影CT图像,标记为先验CT图像;The blood vessel shape digital twin platform obtains the angiography CT image at the virtual coordinates corresponding to the real-time physical coordinates in the virtual blood vessel shape 3D model according to the real-time physical coordinates, and marks it as the prior CT image;

血管走形数字孪生平台利用孪生神经网络,基于实时DSA图像以及先验CT图像进行路径规划适用性实时检测,得到路径规划适用性;The blood vessel shape digital twin platform uses twin neural networks to perform real-time detection of path planning suitability based on real-time DSA images and prior CT images to obtain path planning suitability;

血管走形数字孪生平台根据路径规划适用性,在虚拟血管走形三维模型进行更新位点的识别,得到虚拟血管走形三维模型中的更新位点;The blood vessel shape digital twin platform identifies the update location in the virtual blood vessel shape three-dimensional model according to the path planning applicability, and obtains the update location in the virtual blood vessel shape three-dimensional model;

在虚拟血管走形三维模型中的更新位点处,利用更新位点处对应的实时DSA图像对虚拟血管走形三维模型进行更新;At an update position in the virtual vascular shape three-dimensional model, the virtual vascular shape three-dimensional model is updated using a real-time DSA image corresponding to the update position;

血管走形数字孪生平台,基于更新后的虚拟血管走形三维模型,利用路径规划算法在更新位点和磁控介入终点规划出磁控介入更新虚拟路径;The vascular shape digital twin platform plans a virtual path for magnetically controlled intervention update at the update site and the end point of magnetically controlled intervention based on the updated virtual vascular shape 3D model using a path planning algorithm.

血管走形数字孪生平台将磁控介入更新虚拟路径通过交互通道实时反馈至磁导航仪器,由磁导航仪器实时控制磁性介入导丝依据磁控介入更新虚拟路径进行实时介入移动。The digital twin platform for vascular shape will feed back the updated virtual path of magnetically controlled intervention to the magnetic navigation instrument through the interactive channel in real time. The magnetic navigation instrument will then control the magnetic intervention guidewire to perform real-time intervention movement based on the updated virtual path of magnetically controlled intervention.

对路径规划适用性的检测方法,包括:Methods for testing the suitability of path planning include:

将实时DSA图像输入至孪生神经网络中第一个CNN网络结构中,由孪生神经网络中第一个CNN网络结构输出实时DSA图像中的血管特征;The real-time DSA image is input into the first CNN network structure in the twin neural network, and the first CNN network structure in the twin neural network outputs the vascular features in the real-time DSA image;

将实时CT图像输入至孪生神经网络中第二个CNN网络结构中,由孪生神经网络中第二个CNN网络结构输出先验CT图像中的血管特征;The real-time CT image is input into the second CNN network structure in the twin neural network, and the second CNN network structure in the twin neural network outputs the vascular features in the prior CT image;

利用孪生神经网络的损失函数对路径规划适用性检测,路径规划适用性的表达式为:The loss function of the twin neural network is used to detect the suitability of path planning. The expression of path planning suitability is:

Match_goal=-(1-Loss)rlog(Loss);式中,Match_goal为路径规划适用性,Loss为孪生神经网络的损失函数,r为人工调控参数;Match_goal=-(1-Loss) r log(Loss); where Match_goal is the path planning suitability, Loss is the loss function of the twin neural network, and r is the manual control parameter;

人工调控参数用于在虚拟血管走形三维模型的更新中加入人为意志;The artificial control parameters are used to add human will into the updating of the virtual vascular shape three-dimensional model;

其中,孪生神经网络的损失函数为:Among them, the loss function of the twin neural network is:

Loss=MSE(out1,out2);式中,Loss为损失函数,out1为孪生神经网络中第一个CNN网络结构的输出,out2为孪生神经网络中第二个CNN网络结构的输出,MSE为均方误差函数体,MSE(out1,out2)为out1和out2间的均方误差。Loss=MSE(out1,out2); where Loss is the loss function, out1 is the output of the first CNN network structure in the twin neural network, out2 is the output of the second CNN network structure in the twin neural network, MSE is the mean square error function, and MSE(out1,out2) is the mean square error between out1 and out2.

本发明在沿规划出的介入路径进行介入行进时,会实时获取显示当前血管形状和结构的DSA图像,通过孪生神经网络对DSA图像和三维模型中显示此处血管形状和结构的CT图像中自适应分辨出当前介入路径是否适用当前血管介入,并根据适用性检测结果进行介入路径的重新规划,即进行介入路径的修正,保障介入准确性,利用实时DSA图像代表的实时数据和预先获知的CT图像代表的先验知识进行匹配,完成路径规划修正,实现的由计算机全程控制磁控介入过程,实现在边控制磁性介入导丝介入行进同时,边进行实时路径规划更新。因此,本发明实现了自适应的介入路径规划修正,增强介入路径的规划鲁棒性。When the present invention performs intervention along the planned intervention path, it will obtain a DSA image showing the current blood vessel shape and structure in real time, and adaptively distinguish whether the current intervention path is suitable for the current blood vessel intervention from the DSA image and the CT image showing the blood vessel shape and structure in the three-dimensional model through the twin neural network, and re-plan the intervention path according to the applicability detection result, that is, correct the intervention path, ensure the accuracy of the intervention, match the real-time data represented by the real-time DSA image with the prior knowledge represented by the pre-acquired CT image, complete the path planning correction, and realize the whole process of magnetic control intervention by computer, and realize the real-time path planning update while controlling the magnetic intervention guide wire intervention. Therefore, the present invention realizes adaptive intervention path planning correction and enhances the planning robustness of the intervention path.

具体的,本发明利用孪生神经网络识别出当前的血管形状和结构(血管特征)与虚拟血管走形三维模型中相同位置处的血管形状和结构存在不同,即实现了对血管形状和结构的变化检测,血管形状和结构发生变化或者之前虚拟血管走形三维模型中血管形状和结构构建的不准确,当前的介入路径并不适用,因此需要对介入路径进行修正/重规划,从而实现对介入路径的更新位点进行自适应识别,进而自适应修正介入路径,保证了磁控介入的实时准确性,维持整个介入过程中磁控介入的准确性。Specifically, the present invention utilizes a twin neural network to identify that the current vascular shape and structure (vascular features) are different from the vascular shape and structure at the same position in the virtual vascular trajectory three-dimensional model, thereby realizing the detection of changes in vascular shape and structure. If the vascular shape and structure change or the vascular shape and structure in the previous virtual vascular trajectory three-dimensional model are inaccurately constructed, the current interventional path is not applicable, and therefore the interventional path needs to be corrected/replanned, thereby realizing adaptive identification of the updated site of the interventional path, and then adaptively correcting the interventional path, thereby ensuring the real-time accuracy of magnetically controlled intervention and maintaining the accuracy of magnetically controlled intervention during the entire intervention process.

其中,本发明利用孪生神经网络的损失函数量化路径规划适用性,实现了损失函数越大,血管形状和结构相较虚拟血管走形三维模型中变化程度越高,使得路径规划适用性越低,损失函数越小,血管形状和结构相较虚拟血管走形三维模型中变化程度越低,使得路径规划适用性越高,符合真实情况,实现更新位点的自适应识别。Among them, the present invention uses the loss function of the twin neural network to quantify the applicability of path planning, and realizes that the larger the loss function, the higher the degree of change of the blood vessel shape and structure compared with the virtual blood vessel shape three-dimensional model, which makes the path planning applicability lower; the smaller the loss function, the lower the degree of change of the blood vessel shape and structure compared with the virtual blood vessel shape three-dimensional model, which makes the path planning applicability higher, which is in line with the actual situation and realizes adaptive identification of update sites.

而且还在路径规划适用性中添加人工调控参数,可以通过调节r来人为决定对介入路径进行重新规划,添加人为意志,在人为期望修正介入路径的情况下,可通过人为调控介入路径的修正,实现自适应控制和人工控制相结合,满足各种场景需要。在不需要人工调控时,可将r赋值为1,需要人工调控时,将r赋值为大于1且满足KPI大于预设阈值的值,具体根据实景应用场景决定。In addition, a manual control parameter is added to the path planning applicability. The intervention path can be replanned manually by adjusting r. In addition, when the intervention path is expected to be corrected manually, the intervention path can be corrected manually to achieve a combination of adaptive control and manual control to meet the needs of various scenarios. When manual control is not required, r can be assigned a value of 1. When manual control is required, r can be assigned a value greater than 1 and satisfying the KPI greater than the preset threshold, which is determined according to the actual application scenario.

对虚拟血管走形三维模型中更新位点的识别方法,包括:The method for identifying the update position in the virtual vascular shape three-dimensional model includes:

将路径规划适用性与预设阈值进行比较,其中,The path planning suitability is compared with a preset threshold, where

当路径规划适用性大于或等于预设阈值,则将先验CT图像对应的虚拟坐标标定为虚拟血管走形三维模型中更新位点;When the path planning applicability is greater than or equal to a preset threshold, the virtual coordinates corresponding to the prior CT image are calibrated as update positions in the virtual vascular shape three-dimensional model;

当路径规划适用性小于预设阈值,则将先验CT图像对应的虚拟坐标标定为虚拟血管走形三维模型中非更新位点。When the path planning applicability is less than a preset threshold, the virtual coordinates corresponding to the prior CT image are calibrated as non-updated locations in the virtual vascular shape three-dimensional model.

利用更新位点处对应的实时DSA图像对虚拟血管走形三维模型的更新方法,包括:The method for updating the virtual vascular shape three-dimensional model using the real-time DSA image corresponding to the update site includes:

将更新位点处对应的实时DSA图像的血管特征,替换虚拟血管走形三维模型中更新位点处对应的先验CT图像的血管特征,得到更新后的虚拟血管走形三维模型。The vascular features of the real-time DSA image corresponding to the updated position are used to replace the vascular features of the priori CT image corresponding to the updated position in the virtual vascular shape three-dimensional model to obtain an updated virtual vascular shape three-dimensional model.

如图2所示,本发明提供了一种基于人工智能和CT的磁控介入控制系统,其特征在于,应用于权利要求1-9任一项的一种基于人工智能和CT的磁控介入控制方法,磁控介入控制系统包括:As shown in FIG2 , the present invention provides a magnetic control intervention control system based on artificial intelligence and CT, characterized in that the magnetic control intervention control method based on artificial intelligence and CT applied to any one of claims 1 to 9, the magnetic control intervention control system comprises:

图像采集单元,用于获取血管造影CT图像、DSA图像;An image acquisition unit, used for acquiring angiography CT images and DSA images;

图像处理单元,用于通过人工智能识别模型,在血管造影CT图像中对表征血管的图像像素依据血管走形进行标定处理,得到血管走形标定图像;An image processing unit is used to calibrate the image pixels representing the blood vessels in the angiography CT image according to the shape of the blood vessels through an artificial intelligence recognition model to obtain a calibrated image of the blood vessel shape;

三维重建单元,用于通过三维重建技术,基于血管走形标定图像进行三维空间的物理重建,得到血管走形三维模型;A three-dimensional reconstruction unit, used to perform physical reconstruction of the three-dimensional space based on the vascular shape calibration image by using the three-dimensional reconstruction technology to obtain a three-dimensional model of the vascular shape;

平台搭建单元,用于利用高斯-克吕格投影法,依据磁性介入导丝、血管走形三维模型进行数字孪生平台的虚拟搭建,得到包含虚拟磁性介入导丝、虚拟血管走形三维模型的血管走形数字孪生平台;The platform building unit is used to virtually build a digital twin platform based on the magnetic intervention guidewire and the three-dimensional model of the blood vessel shape by using the Gauss-Krüger projection method, so as to obtain a blood vessel shape digital twin platform including a virtual magnetic intervention guidewire and a virtual three-dimensional model of the blood vessel shape;

平台运行单元,连接DSA系统,用于基于血管走形数字孪生平台,利用DSA系统在虚拟血管走形三维模型中实时搭建虚拟磁性介入导丝的虚拟磁控介入路径;The platform operation unit is connected to the DSA system and is used to build a virtual magnetic intervention path of a virtual magnetic intervention guidewire in real time in a virtual vascular shape three-dimensional model based on the vascular shape digital twin platform using the DSA system;

磁控介入单元,包含磁导航仪器,用于接收血管走形数字孪生平台反馈的虚拟磁控介入路径,并实时控制磁性介入导丝依据虚拟磁控介入路径进行实时介入移动。The magnetically controlled intervention unit includes a magnetic navigation instrument, which is used to receive the virtual magnetically controlled intervention path fed back by the digital twin platform of vascular shape, and to control the magnetic intervention guide wire in real time to perform real-time intervention movement according to the virtual magnetically controlled intervention path.

其中,平台运行单元利用DSA系统在虚拟血管走形三维模型中实时搭建虚拟磁性介入导丝的虚拟磁控介入路径,包括:The platform operation unit uses the DSA system to build a virtual magnetic intervention path for the virtual magnetic intervention guidewire in real time in the virtual 3D model of vascular shape, including:

血管走形数字孪生平台,基于虚拟血管走形三维模型,利用路径规划算法在磁控介入起点和磁控介入终点规划出磁控介入基础虚拟路径;The vascular shape digital twin platform, based on the virtual vascular shape 3D model, uses the path planning algorithm to plan the basic virtual path of magnetically controlled intervention at the starting point and end point of magnetically controlled intervention;

血管走形数字孪生平台将磁控介入基础虚拟路径通过交互通道实时反馈至磁导航仪器,由磁导航仪器实时控制磁性介入导丝依据磁控介入基础虚拟路径进行实时介入移动;The blood vessel shape digital twin platform feeds back the magnetic control intervention basic virtual path to the magnetic navigation instrument in real time through the interactive channel, and the magnetic navigation instrument controls the magnetic intervention guide wire to perform real-time intervention movement according to the magnetic control intervention basic virtual path.

通过DSA系统,在磁控介入导丝沿磁控介入基础虚拟路径进行实时介入移动过程中,获取磁控介入导丝的实时物理坐标,并获取磁控介入导丝所处实时物理坐标处的实时DSA图像,同时将实时DSA图像和实时物理坐标通过交互通道传输至血管走形数字孪生平台;Through the DSA system, when the magnetically controlled interventional guidewire is moving in real time along the magnetically controlled interventional basic virtual path, the real-time physical coordinates of the magnetically controlled interventional guidewire are obtained, and the real-time DSA image at the real-time physical coordinates of the magnetically controlled interventional guidewire is obtained. At the same time, the real-time DSA image and the real-time physical coordinates are transmitted to the vascular shape digital twin platform through the interactive channel.

血管走形数字孪生平台根据实时物理坐标,在虚拟血管走形三维模型中,获取实时物理坐标对应的虚拟坐标处的血管造影CT图像,标记为先验CT图像;The vascular shape digital twin platform obtains the angiography CT image at the virtual coordinates corresponding to the real-time physical coordinates in the virtual vascular shape 3D model according to the real-time physical coordinates, and marks it as the prior CT image;

血管走形数字孪生平台利用孪生神经网络,基于实时DSA图像以及先验CT图像进行路径规划适用性实时检测,得到路径规划适用性;The blood vessel shape digital twin platform uses twin neural networks to perform real-time detection of path planning suitability based on real-time DSA images and prior CT images to obtain path planning suitability;

血管走形数字孪生平台根据路径规划适用性,在虚拟血管走形三维模型进行更新位点的识别,得到虚拟血管走形三维模型中的更新位点;The blood vessel shape digital twin platform identifies the update location in the virtual blood vessel shape three-dimensional model according to the path planning applicability, and obtains the update location in the virtual blood vessel shape three-dimensional model;

在虚拟血管走形三维模型中的更新位点处,利用更新位点处对应的实时DSA图像对虚拟血管走形三维模型进行更新;At an update position in the virtual vascular shape three-dimensional model, the virtual vascular shape three-dimensional model is updated using a real-time DSA image corresponding to the update position;

血管走形数字孪生平台,基于更新后的虚拟血管走形三维模型,利用路径规划算法在更新位点和磁控介入终点规划出磁控介入更新虚拟路径;The vascular shape digital twin platform plans a virtual path for magnetically controlled intervention update at the update site and the end point of magnetically controlled intervention based on the updated virtual vascular shape 3D model using a path planning algorithm.

血管走形数字孪生平台将磁控介入更新虚拟路径通过交互通道实时反馈至磁导航仪器,由磁导航仪器实时控制磁性介入导丝依据磁控介入更新虚拟路径进行实时介入移动。The digital twin platform for vascular shape will feed back the updated virtual path of magnetically controlled intervention to the magnetic navigation instrument through the interactive channel in real time. The magnetic navigation instrument will then control the magnetic intervention guidewire to perform real-time intervention movement based on the updated virtual path of magnetically controlled intervention.

本发明依据磁性介入导丝、血管走形三维模型进行数字孪生平台的虚拟搭建,得到包含虚拟磁性介入导丝、虚拟血管走形三维模型的血管走形数字孪生平台,使得磁控介入路径规划在开发测试阶段可以在贴近真实环境的虚拟空间中进行大量的测试,有效提升磁控介入导丝在真实环境中介入运动时的安全性,而且虚拟空间和物理空间的实时同步,让磁控介入导丝能够实时地从数字孪生平台的虚拟空间中获得实时适应血管真实结构的介入路径更新,将介入路径的规划和介入行进的磁控分开,避免相互挤占资源,有效减轻磁控导航仪机载计算机压力的同时也能提高磁控介入行进的效率,保障介入路径的规划准确性和安全性。The present invention virtually constructs a digital twin platform based on a magnetic interventional guidewire and a three-dimensional model of vascular shape, and obtains a vascular shape digital twin platform including a virtual magnetic interventional guidewire and a virtual three-dimensional model of vascular shape, so that a large number of tests can be carried out on the magnetically controlled interventional path planning in a virtual space close to the real environment during the development and testing phase, thereby effectively improving the safety of the magnetically controlled interventional guidewire during interventional movement in a real environment. Moreover, the real-time synchronization of the virtual space and the physical space enables the magnetically controlled interventional guidewire to obtain real-time interventional path updates that adapt to the real structure of the blood vessel from the virtual space of the digital twin platform in real time, separates the planning of the interventional path from the magnetic control of the interventional movement, avoids mutual crowding out of resources, effectively reduces the pressure on the onboard computer of the magnetically controlled navigator, and can also improve the efficiency of the magnetically controlled interventional movement, thereby ensuring the accuracy and safety of the planning of the interventional path.

本发明不仅可以实现更加精准的介入手术操作,还能够极大减少介入医务人员的放射接触。The present invention can not only realize more precise interventional surgical operations, but also greatly reduce the radiation exposure of interventional medical personnel.

以上实施例仅为本申请的示例性实施例,不用于限制本申请,本申请的保护范围由权利要求书限定。本领域技术人员可以在本申请的实质和保护范围内,对本申请做出各种修改或等同替换,这种修改或等同替换也应视为落在本申请的保护范围内。The above embodiments are only exemplary embodiments of the present application and are not intended to limit the present application. The protection scope of the present application is defined by the claims. Those skilled in the art may make various modifications or equivalent substitutions to the present application within the essence and protection scope of the present application, and such modifications or equivalent substitutions shall also be deemed to fall within the protection scope of the present application.

Claims (5)

1. The utility model provides a magnetic control intervenes control system based on artificial intelligence and CT which characterized in that, magnetic control intervenes control system includes:
The image acquisition unit is used for acquiring angiography CT images and DSA images;
The image processing unit is used for calibrating image pixels representing blood vessels in the angiography CT image according to blood vessel shape variation through the artificial intelligent recognition model to obtain a blood vessel shape variation calibration image;
The three-dimensional reconstruction unit is used for carrying out physical reconstruction of a three-dimensional space based on the blood vessel shape-shifting calibration image by a three-dimensional reconstruction technology to obtain a blood vessel shape-shifting three-dimensional model;
The platform building unit is used for virtually building the digital twin platform according to the magnetic intervention guide wire and the blood vessel shape-shifting three-dimensional model by utilizing a Gaussian-Krueger projection method to obtain the blood vessel shape-shifting digital twin platform comprising the virtual magnetic intervention guide wire and the virtual blood vessel shape-shifting three-dimensional model;
The platform running unit is connected with the DSA system and is used for building a virtual magnetic control intervention path of the virtual magnetic intervention guide wire in a virtual blood vessel shape three-dimensional model in real time based on the blood vessel shape digital twin platform by utilizing the DSA system;
the magnetic control intervention unit comprises a magnetic navigation instrument, is used for receiving a virtual magnetic control intervention path fed back by the blood vessel shape-changing digital twin platform, and controls the magnetic intervention guide wire to perform real-time intervention movement according to the virtual magnetic control intervention path in real time;
the platform operation unit builds a virtual magnetic control intervention path of a virtual magnetic intervention guide wire in real time in a virtual blood vessel shape-changing three-dimensional model by using a DSA system, and the platform operation unit comprises:
The vessel shape-changing digital twin platform is based on a virtual vessel shape-changing three-dimensional model, and a magnetic control intervention basic virtual path is planned at a magnetic control intervention starting point and a magnetic control intervention ending point by utilizing a path planning algorithm;
The vessel shape-moving digital twin platform feeds back the magnetic control intervention basic virtual path to the magnetic navigation instrument in real time through the interaction channel, and the magnetic intervention guide wire is controlled by the magnetic navigation instrument in real time to perform real-time intervention movement according to the magnetic control intervention basic virtual path;
Acquiring real-time physical coordinates of the magnetic control intervention guide wire in the process of performing real-time intervention movement along a virtual path of a magnetic control intervention foundation by using a DSA system, acquiring a real-time DSA image of the magnetic control intervention guide wire at the real-time physical coordinates, and simultaneously transmitting the real-time DSA image and the real-time physical coordinates to a blood vessel shape-moving digital twin platform through an interactive channel;
According to the real-time physical coordinates, the vessel shape-changing digital twin platform acquires angiography CT images at virtual coordinates corresponding to the real-time physical coordinates in the virtual vessel shape-changing three-dimensional model, and marks the angiography CT images as priori CT images;
The vessel shape-shifting digital twin platform utilizes a twin neural network to carry out real-time detection on the suitability of path planning based on a real-time DSA image and a priori CT image, so as to obtain the suitability of path planning;
The vessel shape-moving digital twin platform carries out the identification of the update sites on the virtual vessel shape-moving three-dimensional model according to the path planning applicability, and the update sites in the virtual vessel shape-moving three-dimensional model are obtained;
at an update site in the virtual vessel shape three-dimensional model, updating the virtual vessel shape three-dimensional model by using a real-time DSA image corresponding to the update site;
the vessel shape-changing digital twin platform is used for planning a magnetic control intervention updating virtual path at an updating site and a magnetic control intervention terminal point by utilizing a path planning algorithm based on the updated virtual vessel shape-changing three-dimensional model;
the vessel shape-moving digital twin platform feeds the magnetic control intervention updating virtual path back to the magnetic navigation instrument in real time through the interaction channel, and the magnetic intervention guide wire is controlled by the magnetic navigation instrument in real time to perform real-time intervention movement according to the magnetic control intervention updating virtual path;
the method for detecting the applicability of the vessel shape-changing digital twin platform to path planning comprises the following steps:
Inputting the real-time DSA image into a first CNN network structure in the twin neural network, and outputting the vascular characteristics in the real-time DSA image by the first CNN network structure in the twin neural network;
inputting the real-time CT image into a second CNN network structure in the twin neural network, and outputting vessel characteristics in the prior CT image by the second CNN network structure in the twin neural network;
Detecting path planning applicability by using a loss function of a twin neural network, wherein the path planning applicability has the following expression: match_ goal = - (1-Loss) r log (Loss); in the formula, match_ goal is path planning applicability, loss is a Loss function of the twin neural network, and r is an artificial regulation parameter;
the artificial regulation parameters are used for adding artificial will in the updating of the virtual vessel shape-changing three-dimensional model;
Wherein, the loss function of the twin neural network is:
loss=mse (out 1, out 2); wherein Loss is a Loss function, out1 is the output of a first CNN network structure in the twin neural network, out2 is the output of a second CNN network structure in the twin neural network, MSE is a mean square error function body, and MSE (out 1, out 2) is the mean square error between out1 and out 2;
the method for identifying the update sites in the virtual vessel shape three-dimensional model by the vessel shape digital twin platform comprises the following steps:
comparing the path planning suitability with a preset threshold, wherein,
When the path planning applicability is greater than or equal to a preset threshold, calibrating virtual coordinates corresponding to the prior CT image as update sites in the virtual vessel shape three-dimensional model;
When the path planning applicability is smaller than a preset threshold, calibrating virtual coordinates corresponding to the prior CT image as non-updated sites in the virtual blood vessel walking three-dimensional model;
The method for updating the virtual blood vessel shape three-dimensional model by using the corresponding real-time DSA image at the updating site by the blood vessel shape digital twin platform comprises the following steps:
and replacing the blood vessel characteristics of the corresponding real-time DSA image at the update site with the blood vessel characteristics of the corresponding priori CT image at the update site in the virtual blood vessel shape three-dimensional model to obtain an updated virtual blood vessel shape three-dimensional model.
2. The magnetic control interventional control system based on artificial intelligence and CT according to claim 1, wherein the calibration method of the image processing unit for calibrating the blood vessel shape calibration image comprises the following steps:
randomly selecting a plurality of angiography CT images as sample images;
Marking image pixels representing blood vessels in the sample image as target pixels;
Taking the sample image as an input item of a YOLO V3 neural network, taking the target pixel as an output item of the YOLO V3 neural network, and carrying out mapping learning on the input item of the YOLO V3 neural network and the output item of the YOLO V3 neural network by utilizing the YOLO V3 neural network to obtain the artificial intelligent recognition model;
Identifying image pixels representing blood vessels in each angiography CT image by using the artificial intelligent model, and smoothly linking the image pixels representing the blood vessels by using a B-spline curve smoothing method to obtain calibration lines representing the shape of the blood vessels;
And taking the angiography CT image with the calibration lines as the blood vessel shape-changing calibration image.
3. The magnetic control intervention control system based on artificial intelligence and CT according to claim 1, wherein the three-dimensional reconstruction unit reconstructs the three-dimensional model of the blood vessel shape by using a three-dimensional reconstruction technology 3DMax, and marks a magnetic control intervention starting point and a magnetic control intervention ending point on the three-dimensional model of the blood vessel shape by using the three-dimensional reconstruction technology 3 DMax.
4. The magnetic control intervention control system based on artificial intelligence and CT as set forth in claim 1, wherein the method for constructing the vessel shape-changing digital twin platform by the platform construction unit comprises the following steps:
developing a digital twin platform by utilizing Unity3D, and loading and displaying the magnetic intervention guide wire and blood vessel shape-changing three-dimensional model in the digital twin platform to obtain the virtual magnetic intervention guide wire and virtual blood vessel shape-changing three-dimensional model;
mapping physical coordinates of the magnetic intervention guide wire to virtual coordinates of the virtual magnetic intervention guide wire in the digital twin platform by using a Gaussian-Kriging projection method, and mapping physical coordinates of the blood vessel shape-moving three-dimensional model to virtual coordinates of the virtual blood vessel shape-moving three-dimensional model in the digital twin platform;
establishing an interaction channel for data interaction between the magnetic intervention physical guide wire and the virtual magnetic intervention guide wire;
and constructing the vessel shape-changing digital twin platform.
5. The magnetic control intervention control system based on artificial intelligence and CT as set forth in claim 1, wherein the method for the platform construction unit to coordinate map physical coordinates of the magnetic intervention guide wire and the blood vessel shape three-dimensional model by using a Gauss-Gauss projection method comprises the following steps:
selecting a plurality of first control points from a blood vessel shape three-dimensional model, recording three-dimensional coordinates of the first control points, finding positions of the selected first control points corresponding to observation points in a real environment, recording longitude and latitude coordinates of the observation points, and converting the longitude and latitude coordinates containing height information recorded by each observation point into three-dimensional coordinates in a Cartesian coordinate system through Gauss-Krueger projection orthometric formula projection;
estimating coordinate system deviation of a blood vessel shape three-dimensional model center point from longitude and latitude coordinate projection conversion to a Cartesian coordinate system origin by using a least square method according to the three-dimensional coordinates of a plurality of first control points and the three-dimensional coordinates of the corresponding observation points after the longitude and latitude coordinate projection conversion;
the three-dimensional coordinates of each model point in the physical space where the three-dimensional model of the blood vessel is located are obtained by adding the three-dimensional coordinates obtained by projection conversion of the longitude and latitude coordinates of each model point in the physical space where the three-dimensional model of the blood vessel is located through a Gaussian-Kelvin projection orthometric formula and the deviations of the coordinate system, and the three-dimensional coordinates of the corresponding point in the virtual space where the three-dimensional model of the virtual blood vessel is located are obtained under the Cartesian coordinate system;
Subtracting the coordinate system deviation from the three-dimensional coordinates of each model point in the virtual space where the virtual vessel shape three-dimensional model is located under the Cartesian coordinate system, and obtaining mathematical correlation of longitude and latitude coordinates of corresponding points in the physical space where the vessel shape three-dimensional model is located through the projection conversion of a Gaussian-Kelvin projection inverse solution formula, so that the physical coordinates of the vessel shape three-dimensional model are mapped to the virtual coordinates of the virtual vessel shape three-dimensional model in the digital twin platform;
Selecting a plurality of second control points from the magnetic interventional guide wire, recording three-dimensional coordinates of the second control points, finding positions of the selected second control points corresponding to the observation points in a real environment, recording longitude and latitude coordinates of the observation points, and converting the longitude and latitude coordinates containing the height information recorded by each observation point into three-dimensional coordinates in a Cartesian coordinate system through Gauss-Krueger projection orthometric formula projection;
Estimating coordinate system deviation of the magnetic intervention guide wire center point from the longitude and latitude coordinate projection conversion to the origin of a Cartesian coordinate system by using a least square method according to the three-dimensional coordinates of the plurality of second control points and the three-dimensional coordinates of the corresponding observation points after the longitude and latitude coordinate projection conversion;
The three-dimensional coordinates of each model point in the physical space where the magnetic interventional guide wire is located are obtained by adding the three-dimensional coordinates obtained by projection conversion of the Gauss-Gauss projection orthometric formula and the deviations of the coordinate system, and the three-dimensional coordinates of the corresponding point in the virtual space where the virtual magnetic interventional guide wire is located are obtained under the Cartesian coordinate system;
After the coordinate system deviation is subtracted from the three-dimensional coordinate of each model point in the virtual space where the magnetic intervention guide wire is located under the Cartesian coordinate system, the mathematical correlation of the longitude and latitude coordinates of the corresponding point in the physical space where the magnetic intervention guide wire is located is obtained after the projection conversion of the Gaussian-Kelvin projection inverse solution formula, and the mapping of the physical coordinate of the magnetic intervention guide wire to the virtual coordinate of the virtual magnetic intervention guide wire in the digital twin platform is realized.
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