CN117158522A - Daylily drink for improving sleep and preparation method thereof - Google Patents
Daylily drink for improving sleep and preparation method thereof Download PDFInfo
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Abstract
本发明涉及饮品技术领域,尤其涉及一种改善睡眠的黄花菜饮品及其制备方法,其中,改善睡眠的黄花菜饮品由以下重量份的原料组成:黄花菜50‑100份、鞣花酸0.1‑1份、槲皮素0.5‑2份、合欢皮4‑8份、百合18‑24份、茯苓10‑16份、酸枣仁12‑20份、芝麻1‑10份、核桃1‑10份、奇异果20‑40份、香蕉40‑80份、樱桃30‑60份、蜂蜜粉9‑25份、奶粉7‑22份;本发明以黄花菜作为卵磷脂提取的原材料,同时添加与卵磷脂协同改善睡眠的原料,制出一种改善睡眠的黄花菜饮品,具有镇静安眠、缓解疲劳、保护血管的功效,且具有多种风味,适合不同人群,同时用量合理,无成瘾性,不添加任何食品添加剂和防腐剂,健康无害。
The invention relates to the technical field of beverages, and in particular to a daylily drink for improving sleep and a preparation method thereof. The daylily drink for improving sleep consists of the following raw materials by weight: 50-100 parts of daylily and 0.1-100 parts of ellagic acid. 1 part, quercetin 0.5-2 parts, Albizia Julibrissin peel 4-8 parts, lily 18-24 parts, Poria 10-16 parts, jujube kernel 12-20 parts, sesame seeds 1-10 parts, walnuts 1-10 parts, kiwi 20-40 parts of fruits, 40-80 parts of bananas, 30-60 parts of cherries, 9-25 parts of honey powder, and 7-22 parts of milk powder; the present invention uses day lily as the raw material for lecithin extraction, and at the same time adds lecithin to synergistically improve Use the raw materials of sleep to make a daylily drink that improves sleep. It has the effects of calming sleep, relieving fatigue, and protecting blood vessels. It has a variety of flavors and is suitable for different people. At the same time, the dosage is reasonable, non-addictive, and does not add any food. Additives and preservatives, harmless to health.
Description
技术领域Technical field
本发明涉及饮品技术领域,尤其涉及一种改善睡眠的黄花菜饮品及其制备方法。The present invention relates to the technical field of beverages, and in particular, to a daylily beverage for improving sleep and a preparation method thereof.
背景技术Background technique
黄花菜是一种特色经济作物,依靠人工采摘收获,每年约有10%的已开花或残次的黄花菜被废弃,造成巨大的资源浪费。卵磷脂被誉为与蛋白质、维生素并列的“第三营养素”,可被人类的脑部所吸收,可以促进睡眠、缓解焦虑,同时可减少血液中胆固醇的含量,具有保护血管的功效,卵磷脂用量合理可改善睡眠且不会成瘾,从黄花菜中提取卵磷脂可节约成本、避免资源浪费,具有广阔的市场前景;卵磷脂的提取需要采用有机溶剂,造成有机溶剂的残留,残留量超过一定限度对人体有害,对提取到的卵磷脂进行低温超滤,即利用卵磷脂分子体积大于有机溶剂的原理,在低温、高压状态下使得分子体积较小的有机溶剂通过滤网,而留下分子体积较大的卵磷脂,去除有机化学溶剂残留;目前卵磷脂产品多为卵磷脂软胶囊,有效成分含量低,并且添加了较多食品添加剂,卵磷脂颗粒是卵磷脂经喷雾干燥所得,纯度高,吸收率高,不需要添加任何食品添加剂,食用方法多样,可添加在饮品和食物中或者直接服用;鞣花酸和槲皮素与卵磷脂具有相互协同和促进的作用,二者具有抗氧化效果,可防止卵磷脂的氧化,同时具有延长睡眠时间、提高睡眠质量的作用;芝麻、核桃富含维生素E,可防止卵磷脂氧化,并促进卵磷脂的吸收利用;茯苓含有茯苓多糖、茯苓酸等,具有抗疲劳、安神的效果,百合主要含有秋水仙碱等生物碱成分,具有良好的营养滋补功效,同时富含B族维生素,可提升睡眠质量、减少抑郁,合欢皮含有的皂苷有镇静的安神作用,酸枣仁中含有丰富的黄酮类化合物和有机酸等活性成分,这些成分均可与卵磷脂协同发挥安神、催眠的作用;奶粉、奇异果、香蕉、樱桃、蜂蜜等含有的营养物质同样具有改善睡眠的功效,同时可增加风味,有利于肠胃健康,通过喷雾干燥制得粉末更易保存,不易变质。Daylily is a special economic crop that relies on manual picking. About 10% of flowered or defective daylilies are discarded every year, resulting in a huge waste of resources. Lecithin is known as the "third nutrient" alongside protein and vitamins. It can be absorbed by the human brain and can promote sleep and relieve anxiety. It can also reduce the content of cholesterol in the blood and has the effect of protecting blood vessels. Lecithin Reasonable dosage can improve sleep without becoming addictive. Extracting lecithin from daylilies can save costs and avoid waste of resources, and has broad market prospects. The extraction of lecithin requires the use of organic solvents, resulting in residual organic solvents. The residual amount exceeds It is harmful to the human body to a certain extent. The extracted lecithin is subjected to low-temperature ultrafiltration, which uses the principle that the molecular volume of lecithin is larger than that of organic solvents, allowing organic solvents with smaller molecular volumes to pass through the filter at low temperature and high pressure, leaving behind Lecithin with a larger molecular volume removes organic chemical solvent residues; currently, lecithin products are mostly lecithin soft capsules with low content of active ingredients and more food additives added. Lecithin particles are obtained by spray drying of lecithin. The purity High, high absorption rate, no need to add any food additives, various ways of consumption, can be added to drinks and food or taken directly; ellagic acid, quercetin and lecithin have synergistic and promoting effects, and both have anti- The oxidation effect can prevent the oxidation of lecithin, while also having the effect of prolonging sleep time and improving sleep quality; sesame seeds and walnuts are rich in vitamin E, which can prevent the oxidation of lecithin and promote the absorption and utilization of lecithin; Poria cocos contains Poria polysaccharide, Poria cocos Acid, etc., has anti-fatigue and soothing effects. Lily mainly contains alkaloids such as colchicine, which has good nutritional nourishing effects. It is also rich in B vitamins, which can improve sleep quality and reduce depression. The saponins contained in Albizia Julibrissin peel are Calming and soothing effect, jujube kernels are rich in active ingredients such as flavonoids and organic acids. These ingredients can cooperate with lecithin to exert soothing and hypnotic effects; milk powder, kiwi fruit, bananas, cherries, honey, etc. contain nutrients The substance also has the effect of improving sleep, and can also increase flavor and be beneficial to gastrointestinal health. The powder prepared by spray drying is easier to preserve and less likely to deteriorate.
睡眠对身体健康的影响十分重大,失眠或睡眠质量差会造成疲倦、注意力不集中、记忆障碍等后果。目前多采用服用安眠药的方法来治疗失眠,但药物的成瘾性和安全性都对人体健康造成新的伤害,如何充分利用资源,开发一种人体无害、有效改善睡眠、适于饮用的饮品是亟需解决的技术问题。Sleep has a very significant impact on physical health. Insomnia or poor sleep quality can cause fatigue, inattention, memory impairment and other consequences. At present, sleeping pills are mostly used to treat insomnia. However, the addiction and safety of the drugs cause new harm to human health. How to make full use of resources to develop a drink that is harmless to the human body, effective in improving sleep, and suitable for drinking. It is a technical problem that needs to be solved urgently.
发明内容Contents of the invention
有鉴于此,本发明自开花或残次的黄花菜中提取精卵磷脂,制成卵磷脂颗粒,卵磷脂具有促进睡眠、缓解焦虑,减少血液中胆固醇含量的功效。此外,本发明的一种改善睡眠的黄花菜饮品还添加了鞣花酸、槲皮素以及富含维生素E的芝麻、核桃,可以防止卵磷脂氧化失活,同时可与卵磷脂协同作用,更好的发挥改善睡眠的效果;本发明还添加了百合、茯苓、合欢皮、酸枣仁等含有改善睡眠成分的材料以及奇异果、香蕉、樱桃等改善风味的材料,并通过喷雾干燥法加工成粉末,有效延长了保质期。本发明的目的在于提出一种改善睡眠的黄花菜饮品及其制备方法,以得到一种能改善睡眠、不添加防腐剂和食品添加剂、安全健康的饮品。In view of this, the present invention extracts refined lecithin from flowering or defective daylilies to prepare lecithin particles. Lecithin has the effects of promoting sleep, relieving anxiety, and reducing cholesterol content in the blood. In addition, the daylily drink of the present invention for improving sleep also adds ellagic acid, quercetin and sesame seeds and walnuts rich in vitamin E, which can prevent the oxidative inactivation of lecithin, and can synergize with lecithin to make it more The invention also adds materials containing sleep-improving ingredients such as lily, poria, albizia bark, and jujube kernels, as well as flavor-improving materials such as kiwi, banana, and cherry, and is processed into powder by spray drying. , effectively extending the shelf life. The object of the present invention is to propose a daylily drink for improving sleep and a preparation method thereof, so as to obtain a safe and healthy drink that can improve sleep, does not add preservatives and food additives.
基于上述目的,本发明提供了一种改善睡眠的黄花菜饮品,包括以下重量份的原料:黄花菜50-100份、鞣花酸0.1-1份、槲皮素0.5-2份、合欢皮4-8份、百合18-24份、茯苓10-16份、酸枣仁12-20份、芝麻1-10份、核桃1-10份、奇异果20-40份、香蕉40-80份、樱桃30-60份、蜂蜜粉9-25份、奶粉7-22份。Based on the above purpose, the present invention provides a daylily drink for improving sleep, including the following raw materials in parts by weight: 50-100 parts of daylily, 0.1-1 part of ellagic acid, 0.5-2 parts of quercetin, and 4 parts of Albizia Julibrissin. -8 parts, 18-24 parts of lily, 10-16 parts of Poria, 12-20 parts of jujube kernels, 1-10 parts of sesame, 1-10 parts of walnuts, 20-40 parts of kiwi, 40-80 parts of banana, 30 parts of cherries -60 parts, honey powder 9-25 parts, milk powder 7-22 parts.
进一步的,所述黄花菜粉为已开花或残次的黄花菜经冻干研磨后制得。Furthermore, the daylily powder is prepared by freeze-drying and grinding flowered or defective daylilies.
进一步的,所述一种改善睡眠的黄花菜饮品的制备方法包括以下步骤:自黄花菜中提取精卵磷脂并进行喷雾干燥;将合欢皮、百合、茯苓、酸枣仁,制得草药粉;将奇异果、香蕉、樱桃分别制得奇异果粉、香蕉粉、樱桃粉。Further, the preparation method of a daylily drink for improving sleep includes the following steps: extracting sperm lecithin from daylily and spray drying; preparing herbal powder from Albizia Julibrissin peel, lily, Poria cocos and Ziziphus jujuba kernel; Kiwi fruit, banana and cherry are used to prepare kiwi fruit powder, banana powder and cherry powder respectively.
进一步的,所述自黄花菜中提取精卵磷脂并进行喷雾干燥包括以下步骤:Further, the extraction of sperm lecithin from daylily and spray drying includes the following steps:
(1) 将黄花菜冷冻干燥并研磨成粉,制成黄花菜粉;(1) Freeze-dry daylily and grind it into powder to make daylily powder;
(2) 将黄花菜粉加入丙酮中浸泡1-1.5小时,每隔15-20min搅拌混匀一次,浸泡结束后过滤,得到滤渣I;(2) Add day lily powder to acetone and soak for 1-1.5 hours, stir and mix every 15-20 minutes, filter after soaking to obtain filter residue I;
(3) 采用80-95%的乙醇溶液对步骤(2)所得滤渣I进行浸提,提取1-1.5 h,提取温度40-60°C, 提取后用旋转蒸发器,于80~90°C下蒸发掉乙醇,得到粗卵磷脂;(3) Use 80-95% ethanol solution to extract the filter residue I obtained in step (2) for 1-1.5 h at an extraction temperature of 40-60°C. After extraction, use a rotary evaporator to remove the residue at 80-90°C. The ethanol is evaporated to obtain crude lecithin;
(4) 取步骤(3)所得粗卵磷脂用无水乙醇溶解,加入氯化锌,室温搅拌0.5-1h,再经过低温超滤,得到精卵磷脂;(4) Dissolve the crude lecithin obtained in step (3) with absolute ethanol, add zinc chloride, stir at room temperature for 0.5-1h, and then undergo low-temperature ultrafiltration to obtain refined lecithin;
(5) 将步骤(4)所得精卵磷脂经喷雾干燥制成卵磷脂颗粒。(5) The sperm lecithin obtained in step (4) is spray-dried to prepare lecithin particles.
进一步的,步骤(2)所述黄花菜粉和丙酮的用量比为1g:10mL,浸泡时间优选为1.5小时。Further, the dosage ratio of day lily powder and acetone described in step (2) is 1g:10mL, and the soaking time is preferably 1.5 hours.
进一步的,步骤(2)所述80-95%乙醇溶液优选为85%,与滤渣的用量比为1g:12mL,提取时间优选为1h,提取温度优选为50°C。Further, the 80-95% ethanol solution in step (2) is preferably 85%, the dosage ratio to the filter residue is 1g:12mL, the extraction time is preferably 1h, and the extraction temperature is preferably 50°C.
进一步的,步骤(3)所述粗卵磷脂与无水乙醇的用量比为1g:10mL,氯化锌与卵磷脂用量比为1g:10g,低温超滤条件为4°C,100-120Mpa。Further, the dosage ratio of crude lecithin to absolute ethanol in step (3) is 1g:10mL, the dosage ratio of zinc chloride to lecithin is 1g:10g, and the low-temperature ultrafiltration conditions are 4°C, 100-120Mpa.
进一步的,草药粉的制备包括以下步骤:Further, the preparation of herbal powder includes the following steps:
(a) 将合欢皮、百合、茯苓、酸枣仁,加入水中煮沸,冷却后过滤,得到滤渣II和滤液I;(a) Add Albizia Julibrissin peel, lily, Poria cocos and Ziziphus jujube kernels to water and boil, cool and then filter to obtain filter residue II and filtrate I;
(b) 将步骤(a)所得滤渣II再次加水煮沸,冷却后过滤,得到滤液II;(b) Add water to boil the filter residue II obtained in step (a) again, cool and filter to obtain filtrate II;
(c) 合并滤液I和滤液II,采用喷雾干燥机干燥成草药粉(10-300微米)。(c) Combine filtrate I and filtrate II and dry them into herbal powder (10-300 microns) using a spray dryer.
进一步的,芝麻粉、核桃粉、奇异果粉、香蕉粉、樱桃粉的制备主要包括以下步骤:Further, the preparation of sesame powder, walnut powder, kiwi powder, banana powder, and cherry powder mainly includes the following steps:
S1. 将芝麻、核桃烘干后研磨成粉末状,制得芝麻粉和核桃粉;S1. Dry sesame and walnuts and grind them into powder to prepare sesame powder and walnut powder;
S2. 分别将奇异果、香蕉、樱桃通过榨汁机榨成奇异果汁、香蕉汁、樱桃汁;S2. Squeeze kiwi, banana, and cherry into kiwi juice, banana juice, and cherry juice through a juicer respectively;
S3. 分别将奇异果汁、香蕉汁、樱桃汁,通过喷雾干燥制成奇异果粉、香蕉粉、樱桃粉。S3. Make kiwi fruit powder, banana powder and cherry powder by spray drying kiwi juice, banana juice and cherry juice respectively.
进一步的,所得卵磷脂颗粒、草药粉、鞣花酸、槲皮素、芝麻粉、核桃粉、奇异果粉、香蕉粉、樱桃粉,添加奶粉、蜂蜜粉搅拌混匀,用量比为10g:3g:0.2g:0.5g:2g:2g:2g:4g:3g:8g:6g;奇异果粉、香蕉粉、樱桃粉,需添加其中一种,即得本发明一种改善睡眠的黄花菜饮品。Further, the obtained lecithin particles, herbal powder, ellagic acid, quercetin, sesame powder, walnut powder, kiwi powder, banana powder, cherry powder were added to milk powder and honey powder and stirred evenly. The dosage ratio was 10g:3g: 0.2g:0.5g:2g:2g:2g:4g:3g:8g:6g; kiwi fruit powder, banana powder, cherry powder, one of them needs to be added to obtain a daylily drink for improving sleep of the present invention.
进一步的,所述一种改善睡眠的黄花菜饮品,可用水冲调直接饮用,具有不同风味。Furthermore, the daylily drink for improving sleep can be mixed with water and drunk directly, and has different flavors.
与现有技术相比,本发明具有以下有益效果:Compared with the prior art, the present invention has the following beneficial effects:
(1) 本发明采用已经开花或者是残次的黄花菜作为原材料,节约了经济成本,对有限的资源进行了充分的利用,避免了资源浪费,本发明利用卵磷脂可溶于有机溶剂的特性,通过丙酮和乙醇两种有机溶剂对黄花菜中的卵磷脂进行抽提,得到粗卵磷脂,再通过无水乙醇以及氯化锌,对所得粗卵磷脂进行精提,得到精卵磷脂,通过低温超滤,将小分子体积的物质过滤,得到较为纯净的精卵磷脂,减少了化学溶剂的残留,更加的安全。(1) The present invention uses daylilies that have bloomed or are defective as raw materials, which saves economic costs, makes full use of limited resources, and avoids waste of resources. The present invention utilizes the characteristic of lecithin being soluble in organic solvents. , extract the lecithin in daylily through two organic solvents, acetone and ethanol, to obtain crude lecithin, and then refine the obtained crude lecithin through absolute ethanol and zinc chloride to obtain sperm lecithin. Low-temperature ultrafiltration filters small molecular volume substances to obtain purer sperm lecithin, which reduces the residue of chemical solvents and is safer.
(2) 本发明采用喷雾干燥法制得卵磷脂颗粒,相较于市面上所占比例较多的卵磷脂软胶囊,卵磷脂颗粒有效成分含量更高,因此人体吸收率高,并且不需要添加任何食品添加剂,更加的健康安全,食用方法多样,可添加在饮品和食物中或者直接服用。(2) The present invention uses a spray drying method to prepare lecithin granules. Compared with lecithin soft capsules, which account for a larger proportion on the market, the lecithin granules have a higher content of active ingredients, so the human body absorption rate is high, and there is no need to add any Food additives are healthier and safer and can be consumed in various ways. They can be added to drinks and food or taken directly.
(3) 本发明添加防止卵磷脂氧化的鞣花酸和槲皮素,以及富含维生素E的芝麻和核桃,可防止卵磷脂氧化并促进卵磷脂吸收利用,鞣花酸、槲皮素、维生素E均可与卵磷脂产生协同作用,产生比单独使用更好的效果,有效的改善睡眠;本发明还添加了合欢皮、百合、茯苓、酸枣仁等含有镇静安神、促进睡眠成分的材料,与卵磷脂等物质协同作用,更好的发挥改善睡眠的效果。(3) The present invention adds ellagic acid and quercetin that prevent lecithin from oxidizing, as well as sesame seeds and walnuts that are rich in vitamin E, which can prevent lecithin from oxidizing and promote the absorption and utilization of lecithin. Ellagic acid, quercetin, vitamins E can have a synergistic effect with lecithin, producing better effects than used alone, and effectively improving sleep; the present invention also adds materials containing calming, soothing and sleep-promoting ingredients such as albizia bark, lily, poria, jujube kernel, etc. Lecithin and other substances work synergistically to better exert the effect of improving sleep.
(4) 本发明采用喷雾干燥法,将原料加工成微米级超细粉末,经喷雾干燥后的原料含水量极低,不易变质,在不添加任何食品添加剂和防腐剂的情况下有效的延长了保质期,喷雾干燥法获得的微米级超细粉末,便于携带,并且水溶性好,可用水直接冲调饮用。(4) The present invention uses the spray drying method to process the raw materials into micron-level ultra-fine powder. The spray-dried raw materials have extremely low moisture content and are not easy to deteriorate. They can effectively extend the life span without adding any food additives and preservatives. Shelf life: The micron-level ultra-fine powder obtained by spray drying is easy to carry and has good water solubility, and can be directly mixed with water for drinking.
(5) 本发明一种改善睡眠的黄花菜饮品,添加的蜂蜜粉、奶粉、奇异果、香蕉、樱桃,均具备一定的助眠效果,同时有利于肠道健康,赋予饮品不同的风味。与治疗失眠常用的安眠药品相比,具有良好的改善睡眠效果,对人体无害,无成瘾性,还能够提高健康状况,并且风味独特,适合儿童、老人等不同人群饮用。(5) The present invention is a daylily drink for improving sleep. The added honey powder, milk powder, kiwi fruit, banana, and cherry all have certain sleep-aiding effects, are beneficial to intestinal health, and give the drink different flavors. Compared with sleeping drugs commonly used to treat insomnia, it has a good sleep-improving effect, is harmless to the human body, has no addiction, and can also improve health conditions. It has a unique flavor and is suitable for drinking by children, the elderly and other different groups of people.
附图说明Description of drawings
为了更清楚地说明本发明或现有技术中的技术方案,下面将对实施例或现有技术描述中所需要使用的附图作简单地介绍,显而易见地,下面描述中的附图仅仅是本发明,对于本领域普通技术人员来讲,在不付出创造性劳动的前提下,还可以根据这些附图获得其他的附图。In order to more clearly illustrate the present invention or the technical solutions in the prior art, the drawings needed to be used in the description of the embodiments or the prior art will be briefly introduced below. Obviously, the drawings in the following description are only for the purpose of explaining the present invention or the technical solutions in the prior art. For those of ordinary skill in the art, other drawings can be obtained based on these drawings without any creative effort.
图1为本发明卵磷脂颗粒制备方法流程图;Figure 1 is a flow chart of the lecithin granule preparation method of the present invention;
图2为本发明草药粉的制备方法流程图。Figure 2 is a flow chart of the preparation method of herbal medicine powder of the present invention.
具体实施方式Detailed ways
为使本发明的目的、技术方案和优点更加清楚明白,以下结合具体实施例,对本发明进一步详细说明,但本发明并不仅限于以下的实施例。In order to make the purpose, technical solutions and advantages of the present invention more clear, the present invention will be further described in detail below with reference to specific examples, but the present invention is not limited to the following examples.
需要说明的是,无特殊说明外,本发明中涉及到的化学试剂均通过商业渠道购买。It should be noted that, unless otherwise specified, the chemical reagents involved in the present invention were purchased through commercial channels.
实施例1:本发明提供了一种改善睡眠的黄花菜饮品及其制备方法。Example 1: The present invention provides a daylily drink for improving sleep and a preparation method thereof.
所述一种改善睡眠的黄花菜饮品包括以下质量份的组分:The daylily drink for improving sleep includes the following components by mass:
黄花菜100份、鞣花酸0.2份、槲皮素0.5份、合欢皮8份、百合24份、茯苓16份、酸枣仁20份、芝麻10份、核桃10份、奇异果40份、香蕉80份、樱桃60份、蜂蜜粉25份、奶粉22份;100 parts of daylily, 0.2 parts of ellagic acid, 0.5 parts of quercetin, 8 parts of Albizia bark, 24 parts of lily, 16 parts of Poria, 20 parts of jujube kernels, 10 parts of sesame seeds, 10 parts of walnuts, 40 parts of kiwi fruit, 80 parts of banana parts, 60 parts of cherries, 25 parts of honey powder, 22 parts of milk powder;
所述一种改善睡眠的黄花菜饮品的制备方法主要包括以下步骤:The preparation method of the daylily drink for improving sleep mainly includes the following steps:
1. 从黄花菜中提取精卵磷脂并进行喷雾干燥:1. Extract sperm lecithin from daylily and spray-dry:
(1) 将100 g黄花菜冷冻干燥并研磨成粉,制成黄花菜粉;(1) Freeze-dry 100 g of daylily and grind it into powder to make daylily powder;
(2) 将35 g黄花菜粉加入350 mL的丙酮中浸泡1.5小时,每隔15 min搅拌混匀一次,浸泡结束后过滤,得到滤渣I;(2) Add 35 g of day lily powder to 350 mL of acetone and soak for 1.5 hours, stir and mix every 15 minutes, filter after soaking to obtain filter residue I;
(3) 采用420 mL的85%的乙醇溶液对步骤(2)所得滤渣I进行浸提,提取1.5 h,提取温度50°C, 提取后用旋转蒸发器,于90°C下蒸发掉乙醇,得到粗卵磷脂;(3) Use 420 mL of 85% ethanol solution to extract the filter residue I obtained in step (2) for 1.5 h at an extraction temperature of 50°C. After extraction, use a rotary evaporator to evaporate the ethanol at 90°C. Obtain crude lecithin;
(4) 取步骤(3)所得粗卵磷脂用350 mL无水乙醇溶解,加入3.5 g氯化锌,室温搅拌1h,再经过低温超滤,得到精卵磷脂;(4) Dissolve the crude lecithin obtained in step (3) with 350 mL of absolute ethanol, add 3.5 g of zinc chloride, stir at room temperature for 1 hour, and then undergo low-temperature ultrafiltration to obtain sperm lecithin;
(5) 将步骤(4)所得精卵磷脂经喷雾干燥制成卵磷脂颗粒。(5) The sperm lecithin obtained in step (4) is spray-dried to prepare lecithin particles.
2. 草药粉的制备:2. Preparation of herbal powder:
(a)将8 g合欢皮、24 g百合、16 g茯苓、20 g酸枣仁,加入水中煮沸,冷却后过滤,得到滤渣II和滤液I;(a) Add 8 g of Albizia Julibrissin peel, 24 g of Lily, 16 g of Poria cocos, and 20 g of Ziziphus jujuba kernel into water, boil, cool and then filter to obtain filter residue II and filtrate I;
(b) 将步骤(a)所得滤渣II再次加水煮沸,冷却后过滤,得到滤液II;(b) Add water to boil the filter residue II obtained in step (a) again, cool and filter to obtain filtrate II;
(c) 合并滤液I和滤液II,采用喷雾干燥机干燥成草药粉(10-300微米)。(c) Combine filtrate I and filtrate II and dry them into herbal powder (10-300 microns) using a spray dryer.
3. 奇异果粉、核桃粉、芝麻粉的制备:3. Preparation of kiwi fruit powder, walnut powder and sesame powder:
S1. 将芝麻、核桃烘干后研磨成粉末,得到芝麻粉和核桃粉;S1. Dry sesame and walnuts and grind them into powder to obtain sesame powder and walnut powder;
S2. 将奇异果通过榨汁机榨成奇异果汁;S2. Squeeze the kiwi fruit into kiwi juice through a juicer;
S3. 将奇异果汁通过喷雾干燥制成奇异果粉。S3. Make kiwi fruit powder by spray drying kiwi juice.
4. 将卵磷脂颗粒10 g、鞣花酸0.2 g、槲皮素0.5 g、核桃粉1 g、芝麻粉1 g、草药粉3 g、奇异果粉2 g、奶粉8 g、蜂蜜粉6 g搅拌混匀,即得本发明一种改善睡眠的黄花菜饮品。4. Stir 10 g lecithin particles, 0.2 g ellagic acid, 0.5 g quercetin, 1 g walnut powder, 1 g sesame powder, 3 g herbal powder, 2 g kiwi powder, 8 g milk powder, and 6 g honey powder. Mix well to obtain a daylily drink for improving sleep of the present invention.
实施例2:本发明提供了一种改善睡眠的黄花菜饮品及其制备方法。Example 2: The present invention provides a daylily drink for improving sleep and a preparation method thereof.
所述一种改善睡眠的黄花菜饮品包括以下质量份的组分:The daylily drink for improving sleep includes the following components by mass:
黄花菜100份、鞣花酸0.2份、槲皮素0.5份、合欢皮8份、百合24份、茯苓16份、酸枣仁20份、芝麻10份、核桃10份、奇异果40份、香蕉80份、樱桃60份、蜂蜜粉10份、奶粉12份;100 parts of daylily, 0.2 parts of ellagic acid, 0.5 parts of quercetin, 8 parts of Albizia bark, 24 parts of lily, 16 parts of Poria, 20 parts of jujube kernels, 10 parts of sesame seeds, 10 parts of walnuts, 40 parts of kiwi fruit, 80 parts of banana 60 parts of cherries, 10 parts of honey powder, 12 parts of milk powder;
所述一种改善睡眠的黄花菜饮品的制备方法主要包括以下步骤:The preparation method of the daylily drink for improving sleep mainly includes the following steps:
1. 从黄花菜中提取精卵磷脂并进行喷雾干燥:1. Extract sperm lecithin from daylily and spray-dry:
(1) 将100 g黄花菜冷冻干燥并研磨成粉,制成黄花菜粉;(1) Freeze-dry 100 g of daylily and grind it into powder to make daylily powder;
(2) 将35 g黄花菜粉加入350 mL的丙酮中浸泡1.5小时,每隔15 min搅拌混匀一次,浸泡结束后过滤,得到滤渣I;(2) Add 35 g of day lily powder to 350 mL of acetone and soak for 1.5 hours, stir and mix every 15 minutes, filter after soaking to obtain filter residue I;
(3) 采用420 mL的85%的乙醇溶液对步骤(2)所得滤渣I进行浸提,提取1.5 h,提取温度60°C, 提取后用旋转蒸发器,于90°C下蒸发掉乙醇,得到粗卵磷脂;(3) Use 420 mL of 85% ethanol solution to extract the filter residue I obtained in step (2) for 1.5 h at an extraction temperature of 60°C. After extraction, use a rotary evaporator to evaporate the ethanol at 90°C. Obtain crude lecithin;
(4) 取步骤(3)所得粗卵磷脂用350 mL无水乙醇溶解,加入3.5 g氯化锌,室温搅拌0.5 h,再经过低温超滤,得到精卵磷脂;(4) Dissolve the crude lecithin obtained in step (3) with 350 mL of absolute ethanol, add 3.5 g of zinc chloride, stir at room temperature for 0.5 h, and then undergo low-temperature ultrafiltration to obtain sperm lecithin;
(5) 将步骤(4)所得精卵磷脂经喷雾干燥制成卵磷脂颗粒。(5) The sperm lecithin obtained in step (4) is spray-dried to prepare lecithin particles.
2. 草药粉的制备:2. Preparation of herbal powder:
(a) 将8 g合欢皮、24 g百合、16 g茯苓、20 g酸枣仁,加入水中煮沸,冷却后过滤,得到滤渣II和滤液I;(a) Add 8 g of Albizia Julibrissin peel, 24 g of Lily, 16 g of Poria cocos, and 20 g of Ziziphus jujuba kernel into water and boil, cool and then filter to obtain filter residue II and filtrate I;
(b) 将步骤(a)所得滤渣II再次加水煮沸,冷却后过滤,得到滤液II;(b) Add water to boil the filter residue II obtained in step (a) again, cool and filter to obtain filtrate II;
(c) 合并滤液I和滤液II,采用喷雾干燥机干燥成草药粉(10-300微米)。(c) Combine filtrate I and filtrate II and dry them into herbal powder (10-300 microns) using a spray dryer.
3. 香蕉粉、核桃粉、芝麻粉的制备:3. Preparation of banana powder, walnut powder and sesame powder:
S1. 将芝麻、核桃烘干后研磨成粉末,得到芝麻粉和核桃粉;S1. Dry sesame and walnuts and grind them into powder to obtain sesame powder and walnut powder;
S2. 将香蕉通过榨汁机榨成香蕉汁;S2. Squeeze the bananas into banana juice through a juicer;
S3. 将香蕉汁通过喷雾干燥制成香蕉粉。S3. Make banana powder by spray drying banana juice.
4. 将卵磷脂颗粒10 g、鞣花酸0.2 g、槲皮素0.5 g、核桃粉1 g、芝麻粉1 g、草药粉3 g、香蕉粉4 g、奶粉8 g、蜂蜜粉6 g搅拌混匀,即得本发明一种改善睡眠的黄花菜饮品。4. Stir 10 g lecithin particles, 0.2 g ellagic acid, 0.5 g quercetin, 1 g walnut powder, 1 g sesame powder, 3 g herbal powder, 4 g banana powder, 8 g milk powder, and 6 g honey powder. Mix well to obtain a daylily drink for improving sleep of the present invention.
实施例3:本发明提供了一种改善睡眠的黄花菜饮品及其制备方法。Example 3: The present invention provides a daylily drink for improving sleep and a preparation method thereof.
所述一种改善睡眠的黄花菜饮品包括以下质量份的组分:The daylily drink for improving sleep includes the following components by mass:
黄花菜100份、鞣花酸0.2份、槲皮素0.5份、合欢皮8份、百合24份、茯苓16份、酸枣仁20份、芝麻10份、核桃10份、奇异果40份、香蕉80份、樱桃60份、蜂蜜粉25份、奶粉22份;100 parts of daylily, 0.2 parts of ellagic acid, 0.5 parts of quercetin, 8 parts of Albizia bark, 24 parts of lily, 16 parts of Poria, 20 parts of jujube kernels, 10 parts of sesame seeds, 10 parts of walnuts, 40 parts of kiwi fruit, 80 parts of banana parts, 60 parts of cherries, 25 parts of honey powder, 22 parts of milk powder;
所述一种改善睡眠的黄花菜饮品的制备方法主要包括以下步骤:The preparation method of the daylily drink for improving sleep mainly includes the following steps:
1. 从黄花菜中提取精卵磷脂并进行喷雾干燥:1. Extract sperm lecithin from daylily and spray-dry:
(1) 将100 kg黄花菜冷冻干燥并研磨成粉,制成黄花菜粉;(1) Freeze-dry 100 kg of daylily and grind it into powder to make daylily powder;
(2) 将35 kg黄花菜粉加入350 mL的丙酮中浸泡1.5小时,每隔15 min搅拌混匀一次,浸泡结束后过滤,得到滤渣I;(2) Add 35 kg of day lily powder into 350 mL of acetone and soak for 1.5 hours, stir and mix every 15 minutes, filter after soaking to obtain filter residue I;
(3) 采用420 L的85%的乙醇溶液对步骤(2)所得滤渣I进行浸提,提取1.5 h,提取温度50°C, 提取后用旋转蒸发器,于90°C下蒸发掉乙醇,得到粗卵磷脂;(3) Use 420 L of 85% ethanol solution to extract the filter residue I obtained in step (2) for 1.5 h at an extraction temperature of 50°C. After extraction, use a rotary evaporator to evaporate the ethanol at 90°C. Obtain crude lecithin;
(4) 取步骤(3)所得粗卵磷脂用350 L无水乙醇溶解,加入3.5 kg氯化锌,室温搅拌1h,再经过低温超滤,得到精卵磷脂;(4) Dissolve the crude lecithin obtained in step (3) with 350 L of absolute ethanol, add 3.5 kg of zinc chloride, stir at room temperature for 1 hour, and then undergo low-temperature ultrafiltration to obtain sperm lecithin;
(5) 将步骤(4)所得精卵磷脂经喷雾干燥制成卵磷脂颗粒。(5) The sperm lecithin obtained in step (4) is spray-dried to prepare lecithin particles.
2. 草药粉的制备:2. Preparation of herbal powder:
(a) 将8 kg合欢皮、24 kg百合、16 kg茯苓、20 kg酸枣仁,加入水中煮沸,冷却后过滤,得到滤渣II和滤液I;(a) Add 8 kg of Albizia Julibrissin peel, 24 kg of Lily, 16 kg of Poria cocos, and 20 kg of Ziziphus jujube kernels into water, boil, cool and then filter to obtain filter residue II and filtrate I;
(b) 将步骤(a)所得滤渣II再次加水煮沸,冷却后过滤,得到滤液II;(b) Add water to boil the filter residue II obtained in step (a) again, cool and filter to obtain filtrate II;
(c) 合并滤液I和滤液II,采用喷雾干燥机干燥成草药粉(10-300微米)。(c) Combine filtrate I and filtrate II and dry them into herbal powder (10-300 microns) using a spray dryer.
3. 奇异果粉、核桃粉、芝麻粉的制备:3. Preparation of kiwi fruit powder, walnut powder and sesame powder:
S1. 将芝麻、核桃烘干后研磨成粉末,得到芝麻粉和核桃粉;S1. Dry sesame and walnuts and grind them into powder to obtain sesame powder and walnut powder;
S2. 将奇异果通过榨汁机榨成奇异果汁;S2. Squeeze the kiwi fruit into kiwi juice through a juicer;
S3. 将奇异果汁通过喷雾干燥制成奇异果粉。S3. Make kiwi fruit powder by spray drying kiwi juice.
4. 将卵磷脂颗粒10 kg、鞣花酸0.2 kg、槲皮素0.5 kg、核桃粉1 kg、芝麻粉1 kg、草药粉3 kg、奇异果粉2 kg、奶粉8 kg、蜂蜜粉6 kg搅拌混匀,即得本发明一种改善睡眠的黄花菜饮品。4. Stir 10 kg of lecithin granules, 0.2 kg of ellagic acid, 0.5 kg of quercetin, 1 kg of walnut powder, 1 kg of sesame powder, 3 kg of herbal powder, 2 kg of kiwi powder, 8 kg of milk powder, and 6 kg of honey powder. Mix well to obtain a daylily drink for improving sleep of the present invention.
实施例4:本发明提供了一种改善睡眠的黄花菜饮品及其制备方法。Example 4: The present invention provides a daylily drink for improving sleep and a preparation method thereof.
所述一种改善睡眠的黄花菜饮品包括以下质量份的组分:The daylily drink for improving sleep includes the following components by mass:
黄花菜100份、鞣花酸0.2份、槲皮素0.5份、合欢皮8份、百合24份、茯苓16份、酸枣仁20份、芝麻10份、核桃10份、奇异果40份、香蕉80份、樱桃60份、蜂蜜粉7份、奶粉9份;100 parts of daylily, 0.2 parts of ellagic acid, 0.5 parts of quercetin, 8 parts of Albizia bark, 24 parts of lily, 16 parts of Poria, 20 parts of jujube kernels, 10 parts of sesame seeds, 10 parts of walnuts, 40 parts of kiwi fruit, 80 parts of banana 60 parts of cherries, 7 parts of honey powder, 9 parts of milk powder;
所述一种改善睡眠的黄花菜饮品的制备方法主要包括以下步骤:The preparation method of the daylily drink for improving sleep mainly includes the following steps:
1. 从黄花菜中提取精卵磷脂并进行喷雾干燥:1. Extract sperm lecithin from daylily and spray-dry:
(1) 将100 kg黄花菜冷冻干燥并研磨成粉,制成黄花菜粉;(1) Freeze-dry 100 kg of daylily and grind it into powder to make daylily powder;
(2) 将35 kg黄花菜粉加入350 mL的丙酮中浸泡1.5小时,每隔15 min搅拌混匀一次,浸泡结束后过滤,得到滤渣I;(2) Add 35 kg of day lily powder into 350 mL of acetone and soak for 1.5 hours, stir and mix every 15 minutes, filter after soaking to obtain filter residue I;
(3) 采用420 L的85%的乙醇溶液对步骤(2)所得滤渣I进行浸提,提取1.5 h,提取温度50°C, 提取后用旋转蒸发器,于90°C下蒸发掉乙醇,得到粗卵磷脂;(3) Use 420 L of 85% ethanol solution to extract the filter residue I obtained in step (2) for 1.5 h at an extraction temperature of 50°C. After extraction, use a rotary evaporator to evaporate the ethanol at 90°C. Obtain crude lecithin;
(4) 取步骤(3)所得粗卵磷脂用350 L无水乙醇溶解,加入3.5 kg氯化锌,室温搅拌1h,再经过低温超滤,得到精卵磷脂;(4) Dissolve the crude lecithin obtained in step (3) with 350 L of absolute ethanol, add 3.5 kg of zinc chloride, stir at room temperature for 1 hour, and then undergo low-temperature ultrafiltration to obtain sperm lecithin;
(5) 将步骤(4)所得精卵磷脂经喷雾干燥制成卵磷脂颗粒。(5) The sperm lecithin obtained in step (4) is spray-dried to prepare lecithin particles.
2. 草药粉的制备:2. Preparation of herbal powder:
(a) 将8 kg合欢皮、24 kg百合、16 kg茯苓、20 kg酸枣仁,加入水中煮沸,冷却后过滤,得到滤渣II和滤液I;(a) Add 8 kg of Albizia Julibrissin peel, 24 kg of Lily, 16 kg of Poria cocos, and 20 kg of Ziziphus jujube kernels into water, boil, cool and then filter to obtain filter residue II and filtrate I;
(b) 将步骤(a)所得滤渣II再次加水煮沸,冷却后过滤,得到滤液II;(b) Add water to boil the filter residue II obtained in step (a) again, cool and filter to obtain filtrate II;
(c) 合并滤液I和滤液II,采用喷雾干燥机干燥成草药粉(10-300微米)。(c) Combine filtrate I and filtrate II and dry them into herbal powder (10-300 microns) using a spray dryer.
3. 樱桃粉、核桃粉、芝麻粉的制备:3. Preparation of cherry powder, walnut powder and sesame powder:
S1. 将芝麻、核桃烘干后研磨成粉末,得到芝麻粉和核桃粉;S1. Dry sesame and walnuts and grind them into powder to obtain sesame powder and walnut powder;
S2. 将樱桃通过榨汁机榨成樱桃汁;S2. Squeeze the cherries into cherry juice through a juicer;
S3. 将樱桃汁通过喷雾干燥制成樱桃粉。S3. Make cherry powder by spray drying cherry juice.
4. 将卵磷脂颗粒10 kg、鞣花酸0.2 kg、槲皮素0.5 kg、核桃粉1 kg、芝麻粉1 kg、草药粉3 kg、樱桃粉3 kg、奶粉8 kg、蜂蜜粉6 kg搅拌混匀,即得本发明一种改善睡眠的黄花菜饮品。4. Stir 10 kg of lecithin granules, 0.2 kg of ellagic acid, 0.5 kg of quercetin, 1 kg of walnut powder, 1 kg of sesame powder, 3 kg of herbal powder, 3 kg of cherry powder, 8 kg of milk powder, and 6 kg of honey powder. Mix well to obtain a daylily drink for improving sleep of the present invention.
对比例1与实施例1相同,区别在于未添加蜂蜜粉和奇异果;Comparative Example 1 is the same as Example 1, except that honey powder and kiwi fruit are not added;
对比例2与实施例2相同,区别在于未添加鞣花酸和槲皮素;Comparative Example 2 is the same as Example 2, except that ellagic acid and quercetin are not added;
对比例3与实施例3相同,区别在于将奇异果榨汁代替了对奇异果进行喷雾干燥得到的微米级超细粉末。Comparative Example 3 is the same as Example 3, except that the kiwi fruit juice is squeezed instead of the micron-sized ultra-fine powder obtained by spray drying the kiwi fruit.
一、产品感官效果1. Product sensory effects
以实施1-4的一种改善睡眠的黄花菜饮品进行感官效果评定,并以对比例1为对照。对实施例1-4的一种改善睡眠的黄花菜饮品进行品尝。选取10 名品尝专家,采用不记名打分的方式进行。对风味、甜度、酸度、幼滑度、口感、整体感觉5 项指标进行打分,满分为10分,分数越高,表示效果越好,对品尝结果进行统计分析,结果如下:A sleep-improving daylily drink according to Implementations 1-4 was used for sensory effect evaluation, and Comparative Example 1 was used as a control. Taste a daylily drink for improving sleep in Examples 1-4. 10 tasting experts were selected and scored anonymously. Score the five indicators of flavor, sweetness, acidity, smoothness, mouthfeel, and overall feeling. The full score is 10 points. The higher the score, the better the effect. Statistical analysis of the tasting results, the results are as follows:
表1 一种改善睡眠的黄花菜饮品感官效果评定结果Table 1 Evaluation results of sensory effects of a daylily drink that improves sleep
以上数据显示,实例1-4比对比例1的一种改善睡眠的黄花菜饮品,在风味、甜度、口感、整体感觉上有较大优势。The above data shows that Examples 1-4 have greater advantages in flavor, sweetness, mouthfeel, and overall feeling than the sleep-improving daylily drink of Comparative Example 1.
二、产品改善睡眠作用2. Product’s effect on improving sleep
本发明一种改善睡眠的黄花菜饮品,人体推荐剂量为每日80 g/75 kg,其改善睡眠的作用主要由精卵磷脂引起。以实施例1-4的一种改善睡眠的黄花菜饮品的为例,通过动物试验评估改善睡眠作用,以对比例2为对照。The present invention is a daylily drink for improving sleep. The recommended dose for the human body is 80 g/75 kg per day. Its sleep-improving effect is mainly caused by sperm lecithin. Taking the sleep-improving daylily drink of Examples 1-4 as an example, the sleep-improving effect was evaluated through animal experiments, and Comparative Example 2 was used as a control.
1、动物来源:昆明种小白鼠,体重18~22克,清洁级动物。实验动物饲养室温度22±2℃,相对湿度50~70%,动物饲养料,由苏杭实验动物科技发展公司提供。1. Animal source: Kunming white mice, weighing 18~22 grams, clean grade animals. The temperature of the experimental animal breeding room is 22±2°C, and the relative humidity is 50~70%. The animal feeding materials are provided by Suhang Experimental Animal Science and Technology Development Company.
2、剂量设计:分别取10 g实例1-4及对比例2的样品,溶于100 mL水中。2. Dosage design: Take 10 g of samples from Examples 1-4 and Comparative Example 2 respectively, and dissolve them in 100 mL of water.
3、给样途径:灌胃,灌胃容积为0.2 mL/20g。3. Sample administration route: intragastric administration, the intragastric volume is 0.2 mL/20g.
4、实验方法和结果:4. Experimental methods and results:
4.1 实施例1-4及对比例2对小鼠自主活动影响的实验研究4.1 Experimental study on the effects of Examples 1-4 and Comparative Example 2 on the autonomous activities of mice
本方法通过直接观察动物自主活动的自动计数法得以实现。实验原理是将一束光线照射到对侧的光电管上,小鼠在活动记录仪的实验箱中活动时遮断光线一次,就引起电流改变一次,经过放大装置,使电脉冲驱使继电器启动,记数器记录一个数值。于第30天天给药60 min后,采用小鼠自主活动仪记录小鼠放入箱适应1min后,记录10 min内的站立次数和活动次数。重复上次实验3次,取平均值。比较给药组、空白组及阳性对照组小鼠自主活动数。This method is realized by an automatic counting method that directly observes the autonomous activities of animals. The principle of the experiment is to shine a beam of light onto the photoelectric tube on the opposite side. When the mouse moves in the experimental box of the actigraph, the light is interrupted once, which causes the current to change once. After passing through the amplification device, the electrical pulse drives the relay to start, and the recording The counter records a value. On the 30th day after daily administration for 60 minutes, a mouse autonomic activity meter was used to record the number of times the mice stood and moved within 10 minutes after they were placed in the box to adapt for 1 minute. Repeat the last experiment 3 times and take the average value. Compare the number of spontaneous activities of mice in the administration group, blank group and positive control group.
4.2 实施例1-4及对比例2对小鼠睡眠时间实验研究4.2 Experimental study on sleep time of mice in Examples 1-4 and Comparative Example 2
在戊巴比妥钠催眠基础上,小鼠睡眠时间是否延长,若睡眠时间延长,则表明本发明一种改善睡眠的黄花菜饮品具有改善睡眠的作用。于第31天给药60min后,各组小鼠均腹腔注射戊巴比妥钠50mg/kg,睡眠以翻正反射消失为指标,以动物背向下姿势保持30s以上者,判断为翻正反射消失,并观察记录翻正反射消失至觉醒的时间作为持续睡眠时间。On the basis of sodium pentobarbital hypnosis, whether the sleep time of mice is prolonged? If the sleep time is prolonged, it indicates that the sleep-improving daylily drink of the present invention has the effect of improving sleep. Sixty minutes after administration on the 31st day, mice in each group were intraperitoneally injected with 50 mg/kg sodium pentobarbital. The disappearance of the righting reflex during sleep was used as an indicator. If the animal maintained the back-down posture for more than 30 s, it was judged to be a righting reflex. disappear, and observe and record the time from the disappearance of the righting reflex to awakening as the duration of sleep.
表2 对小鼠自主活动的影响Table 2 Effects on autonomous activities of mice
表2的结果显示,实例1-4组小鼠活动次数和站立次数较对比例2减少,表明本发明一种改善睡眠的黄花菜饮品有镇静作用。The results in Table 2 show that the number of activities and standing times of the mice in the Examples 1-4 group was reduced compared with Comparative Example 2, indicating that the sleep-improving daylily drink of the present invention has a sedative effect.
表3 小鼠的持续睡眠时间Table 3 Continuous sleep time of mice
试验结果表明:样品能明显延长小鼠睡眠时间,说明本发明的一种改善睡眠的黄花菜饮品可以有效的改善睡眠质量。The test results show that the sample can significantly extend the sleep time of mice, indicating that the sleep-improving daylily drink of the present invention can effectively improve sleep quality.
三、保质期测试3. Shelf life test
以实施1-4的一种改善睡眠的黄花菜饮品进行保质期测试,并以对比例3为对照。将实例1-4和对比例三所制得的一种改善睡眠的黄花菜饮品置于25°C恒温培养箱内,7 d后观察是否变质。结果显示实例1-4外观和口味无变化,对比例3出现分层现象,发生变质,表明本发明可在不添加食品添加剂和防腐剂的情况下延长保质期,更加健康安全。A daylily drink for improving sleep according to Implementations 1-4 was used for a shelf life test, and Comparative Example 3 was used as a control. A sleep-improving daylily drink prepared in Examples 1-4 and Comparative Example 3 was placed in a 25°C constant temperature incubator and observed after 7 days to see whether it deteriorated. The results showed that the appearance and taste of Examples 1-4 did not change, while Comparative Example 3 showed delamination and deterioration, indicating that the present invention can extend the shelf life without adding food additives and preservatives, making it healthier and safer.
所属领域的普通技术人员应当理解:以上任何实施例的讨论仅为示例性的,并非旨在暗示本发明的范围(包括权利要求)被限于这些例子;在本发明的思路下,以上实施例或者不同实施例中的技术特征之间也可以进行组合,步骤可以以任意顺序实现,并存在如上所述的本发明的不同方面的许多其它变化,为了简明它们没有在细节中提供。Those of ordinary skill in the art should understand that the discussion of any above embodiments is only illustrative, and is not intended to imply that the scope of the present invention (including the claims) is limited to these examples; under the spirit of the present invention, the above embodiments or Combinations between technical features in different embodiments are also possible, steps can be implemented in any order, and there are many other variations of different aspects of the invention as described above, which are not provided in detail for the sake of brevity.
本发明旨在涵盖落入所附权利要求的宽泛范围之内的所有这样的替换、修改和变型。因此,凡在本发明的精神和原则之内,所做的任何省略、修改、等同替换、改进等,均应包含在本发明的保护范围之内。The invention is intended to cover all such alternatives, modifications and variations falling within the broad scope of the appended claims. Therefore, any omissions, modifications, equivalent substitutions, improvements, etc. made within the spirit and principles of the present invention shall be included in the protection scope of the present invention.
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Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102228250A (en) * | 2011-07-08 | 2011-11-02 | 北京工商大学 | Functional food for sleep improvement and preparation method thereof |
CN104069335A (en) * | 2014-07-17 | 2014-10-01 | 江苏东博生物医药有限公司 | Medicine composition capable of improving sleep quality and preparation method of medicine composition as well as application of medicine composition |
KR20160077727A (en) * | 2014-12-24 | 2016-07-04 | 강원대학교산학협력단 | Composition comprising the combined extract of Zizyphus jujuba MILLl and Polyporus cocos for the treatment and prevention of anxiety or insomnia |
CN111838671A (en) * | 2019-04-28 | 2020-10-30 | 天赋能健康产业集团股份有限公司 | Enriched nutrient cereal diet with sleep improving effect and preparation method thereof |
CN112314819A (en) * | 2020-10-30 | 2021-02-05 | 成都致耀医药科技有限公司 | Plant beverage for improving sleep and preparation method thereof |
CN115736252A (en) * | 2022-11-25 | 2023-03-07 | 广州欣盛通健康管理科技有限公司 | Composition for improving sleep and soothing nerves and application of composition in food |
-
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- 2023-08-29 CN CN202311091200.8A patent/CN117158522A/en active Pending
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102228250A (en) * | 2011-07-08 | 2011-11-02 | 北京工商大学 | Functional food for sleep improvement and preparation method thereof |
CN104069335A (en) * | 2014-07-17 | 2014-10-01 | 江苏东博生物医药有限公司 | Medicine composition capable of improving sleep quality and preparation method of medicine composition as well as application of medicine composition |
KR20160077727A (en) * | 2014-12-24 | 2016-07-04 | 강원대학교산학협력단 | Composition comprising the combined extract of Zizyphus jujuba MILLl and Polyporus cocos for the treatment and prevention of anxiety or insomnia |
CN111838671A (en) * | 2019-04-28 | 2020-10-30 | 天赋能健康产业集团股份有限公司 | Enriched nutrient cereal diet with sleep improving effect and preparation method thereof |
CN112314819A (en) * | 2020-10-30 | 2021-02-05 | 成都致耀医药科技有限公司 | Plant beverage for improving sleep and preparation method thereof |
CN115736252A (en) * | 2022-11-25 | 2023-03-07 | 广州欣盛通健康管理科技有限公司 | Composition for improving sleep and soothing nerves and application of composition in food |
Non-Patent Citations (1)
Title |
---|
杨大伟;钟菊英;: "黄花菜粗卵磷脂提取工艺研究", 食品工业科技, no. 01, 25 January 2008 (2008-01-25), pages 204 - 206 * |
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