CN117067796B - Method and system for manufacturing radionuclide applicator, applicator and electronic equipment - Google Patents
Method and system for manufacturing radionuclide applicator, applicator and electronic equipment Download PDFInfo
- Publication number
- CN117067796B CN117067796B CN202311341265.3A CN202311341265A CN117067796B CN 117067796 B CN117067796 B CN 117067796B CN 202311341265 A CN202311341265 A CN 202311341265A CN 117067796 B CN117067796 B CN 117067796B
- Authority
- CN
- China
- Prior art keywords
- ink
- focus
- applicator
- data
- radionuclide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 238000004519 manufacturing process Methods 0.000 title claims abstract description 46
- 238000000034 method Methods 0.000 title claims abstract description 32
- 230000002285 radioactive effect Effects 0.000 claims abstract description 33
- 239000007788 liquid Substances 0.000 claims abstract description 30
- 229920003023 plastic Polymers 0.000 claims abstract description 20
- 239000004033 plastic Substances 0.000 claims abstract description 19
- 238000004806 packaging method and process Methods 0.000 claims abstract description 14
- 239000000758 substrate Substances 0.000 claims description 49
- 230000003902 lesion Effects 0.000 claims description 38
- 238000007639 printing Methods 0.000 claims description 21
- 238000007641 inkjet printing Methods 0.000 claims description 13
- 230000000694 effects Effects 0.000 claims description 10
- 238000004590 computer program Methods 0.000 claims description 8
- 238000003860 storage Methods 0.000 claims description 8
- 239000003550 marker Substances 0.000 claims description 4
- 239000000463 material Substances 0.000 abstract description 5
- 230000007547 defect Effects 0.000 abstract description 2
- 238000009826 distribution Methods 0.000 abstract description 2
- 238000010586 diagram Methods 0.000 description 8
- 238000004891 communication Methods 0.000 description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
- 238000005516 engineering process Methods 0.000 description 4
- 239000011734 sodium Substances 0.000 description 4
- 229920006378 biaxially oriented polypropylene Polymers 0.000 description 3
- 239000011127 biaxially oriented polypropylene Substances 0.000 description 3
- 238000010146 3D printing Methods 0.000 description 2
- 201000004624 Dermatitis Diseases 0.000 description 2
- OAICVXFJPJFONN-OUBTZVSYSA-N Phosphorus-32 Chemical compound [32P] OAICVXFJPJFONN-OUBTZVSYSA-N 0.000 description 2
- 239000004698 Polyethylene Substances 0.000 description 2
- 230000003287 optical effect Effects 0.000 description 2
- -1 polyethylene Polymers 0.000 description 2
- 229920000139 polyethylene terephthalate Polymers 0.000 description 2
- 239000005020 polyethylene terephthalate Substances 0.000 description 2
- 238000005303 weighing Methods 0.000 description 2
- 208000032544 Cicatrix Diseases 0.000 description 1
- 208000002260 Keloid Diseases 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000006978 adaptation Effects 0.000 description 1
- 238000007605 air drying Methods 0.000 description 1
- 208000010668 atopic eczema Diseases 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000001143 conditioned effect Effects 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 201000011066 hemangioma Diseases 0.000 description 1
- 230000001969 hypertrophic effect Effects 0.000 description 1
- 210000001117 keloid Anatomy 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 229940100688 oral solution Drugs 0.000 description 1
- 238000010422 painting Methods 0.000 description 1
- 229940097886 phosphorus 32 Drugs 0.000 description 1
- 229920006267 polyester film Polymers 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 231100000241 scar Toxicity 0.000 description 1
- 230000037387 scars Effects 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B41—PRINTING; LINING MACHINES; TYPEWRITERS; STAMPS
- B41M—PRINTING, DUPLICATING, MARKING, OR COPYING PROCESSES; COLOUR PRINTING
- B41M5/00—Duplicating or marking methods; Sheet materials for use therein
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N5/1001—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy using radiation sources introduced into or applied onto the body; brachytherapy
- A61N5/1028—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy using radiation sources introduced into or applied onto the body; brachytherapy using radiation sources applied onto the body
- A61N5/1029—Radioactive dressings
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B41—PRINTING; LINING MACHINES; TYPEWRITERS; STAMPS
- B41M—PRINTING, DUPLICATING, MARKING, OR COPYING PROCESSES; COLOUR PRINTING
- B41M3/00—Printing processes to produce particular kinds of printed work, e.g. patterns
- B41M3/06—Veined printings; Fluorescent printings; Stereoscopic images; Imitated patterns, e.g. tissues, textiles
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B41—PRINTING; LINING MACHINES; TYPEWRITERS; STAMPS
- B41M—PRINTING, DUPLICATING, MARKING, OR COPYING PROCESSES; COLOUR PRINTING
- B41M5/00—Duplicating or marking methods; Sheet materials for use therein
- B41M5/0023—Digital printing methods characterised by the inks used
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Pathology (AREA)
- Vascular Medicine (AREA)
- Textile Engineering (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Ink Jet (AREA)
Abstract
The invention relates to the technical field of medical equipment, and provides a method and a system for manufacturing a radionuclide applicator, the applicator and electronic equipment, wherein the method comprises the following steps: obtaining the graph data of the focus, wherein the graph data comprises the contour data of the focus and a reference mark corresponding to the contour; the graphic data is imported into an ink-jet printer, and a scale of the ink-jet printer is adjusted to be matched with the reference mark; based on the contour data, controlling an ink-jet printer to print the ink which contains the radioactive feed liquid and is preset according to the focus condition on the base material by ink-jet, so as to obtain a printed base material, and forming the radionuclide applicator after plastic packaging the printed base material. The invention is used for solving the defects that the manufacturing method of the radionuclide applicator is tedious and time-consuming and the distribution uniformity of the radioactive feed liquid on the applicator is not easy to ensure in the prior art.
Description
Technical Field
The present invention relates to the field of medical devices, and more particularly to a method, system, applicator and electronic device for manufacturing a radionuclide applicator.
Background
The radionuclide applicator is a planar source with different shape areas, which is used as a radioactive source for application treatment, is called an applicator or an application source for short, and has definite curative effects on keloids, hypertrophic scars, hemangiomas, dermatitis eczema, superficial tumors and the like.
At present, a radioactive feed liquid (such as phosphorus-32 feed liquid) is generally dripped on a substrate sheared according to the shape and size of a focus of a patient, and then the substrate is dried and packaged into a radionuclide applicator.
Disclosure of Invention
The invention provides a method, a system, an applicator and electronic equipment for manufacturing a radionuclide applicator, which are used for solving the defects that the method for manufacturing the radionuclide applicator is tedious and time-consuming and the distribution uniformity of radioactive liquid on the applicator is not easy to ensure in the prior art.
The present invention provides a method of making a radionuclide applicator comprising:
obtaining the graph data of a focus, wherein the graph data comprises contour data of the focus and a reference mark corresponding to the contour;
importing the graphic data into an inkjet printer, and adjusting a scale of the inkjet printer to be matched with the reference mark;
controlling the ink-jet printer to jet ink containing radioactive feed liquid preset according to the focus state on a substrate based on the contour data to obtain a printed substrate;
wherein the printed substrate is plastic encapsulated to form the radionuclide applicator.
According to the method of manufacturing a radionuclide applicator of the present invention, the acquiring the graphic data of the focus includes:
acquiring a first target image, wherein the first target image is an image acquired after the reference mark is arranged on any side of the focus;
and extracting an image of the reference mark and the contour data of the focus from the first target image as the graphic data.
According to the method of manufacturing a radionuclide applicator of the present invention, the acquiring the graphic data of the focus includes:
acquiring a second target image, wherein the second target image is an image acquired after the reference mark is arranged on any side of the shape of the focus of rubbing;
and extracting an image of the reference mark and the contour data of the focus from the second target image as the graphic data.
According to the method of manufacturing a radionuclide applicator of the present invention, the ink containing the radionuclide liquid is preset according to the condition of the focus, and the method includes:
acquiring a unit ink jet amount of the ink jet printer;
determining a charge of the radioactive feed liquid in ink of the inkjet printer based on the activity requirement of the radionuclide applicator corresponding to the condition of the lesion and the unit inkjet amount.
According to the method of manufacturing a radionuclide applicator of the present invention, the obtaining a unit ink ejection amount of the ink jet printer includes:
acquiring the weight of blank paper;
controlling the ink-jet printer to print an image of a unit area on the blank paper to obtain printing paper;
acquiring the weight of the printing paper;
the unit ink ejection amount of the ink jet printer is determined based on the weight of the blank sheet and the weight of the print sheet.
The present invention also provides a system for making a radionuclide applicator, comprising:
fiducial markers for use as a dimensional reference for lesions;
the image acquisition equipment is used for acquiring the graph data of the focus, wherein the graph data comprises the contour data of the focus and the reference mark corresponding to the contour;
an inkjet printer for inkjet printing ink on a substrate based on the imported profile data;
the processing terminal is used for acquiring the graph data of the focus, importing the graph data into the inkjet printer, adjusting the scale of the inkjet printer to be matched with the reference mark, and controlling the inkjet printer to jet ink containing radioactive feed liquid preset according to the condition of the focus on a substrate based on the contour data to obtain a printed substrate;
wherein the printed substrate is plastic encapsulated to form the radionuclide applicator.
The system for making a radionuclide applicator according to the invention further comprises: plastic packaging equipment;
the plastic packaging device is used for plastic packaging the printing substrate to obtain the radionuclide applicator.
The present invention also provides a radionuclide applicator manufactured using the method of manufacturing a radionuclide applicator as described above or the system for manufacturing a radionuclide applicator as described above.
The invention also provides an electronic device comprising a memory, a processor and a computer program stored on the memory and executable on the processor, the processor implementing a method of making a radionuclide applicator as described above when executing the program.
The present invention also provides a non-transitory computer readable storage medium having stored thereon a computer program which when executed by a processor implements a method of making a radionuclide applicator as described above.
The invention provides a method, a system, an applicator and an electronic device for manufacturing a radionuclide applicator, which are used for acquiring graph data of a focus, wherein the graph data comprises contour data and a reference mark corresponding to the contour; the graphic data is imported into an ink-jet printer, and a scale of the ink-jet printer is adjusted to be matched with the reference mark; based on the contour data, controlling the ink-jet printer to print the ink containing the radioactive feed liquid preset according to the focus condition on the substrate by ink-jet, thereby obtaining the printing substrate corresponding to the focus, and forming the radionuclide applicator after plastic packaging the printing substrate. The obtained profile data of the focus and the figure data of the reference mark corresponding to the profile can provide accurate basis for manufacturing the radionuclide applicator corresponding to the focus in shape and size, and then the radionuclide applicator highly attached to the focus in shape and size can be realized by combining an ink jet printing technology.
Drawings
In order to more clearly illustrate the invention or the technical solutions of the prior art, the following description will briefly explain the drawings used in the embodiments or the description of the prior art, and it is obvious that the drawings in the following description are some embodiments of the invention, and other drawings can be obtained according to the drawings without inventive effort for a person skilled in the art.
FIG. 1 is a flow chart of a method of making a radionuclide applicator provided by the present invention;
FIG. 2 is a schematic diagram of an example of a first target image provided by the present invention;
FIG. 3 is a schematic diagram of an example of graphics data provided by the present invention;
FIG. 4 is a schematic diagram of an example of a second target image provided by the present invention;
FIG. 5 is a diagram of a comparison of an ink jet printed radionuclide applicator with a corresponding lesion provided in an embodiment of the invention;
FIG. 6 is a schematic diagram of a system for manufacturing a radionuclide applicator, according to an embodiment of the invention;
fig. 7 is a schematic structural diagram of an electronic device provided by the present invention.
Detailed Description
For the purpose of making the objects, technical solutions and advantages of the present invention more apparent, the technical solutions of the present invention will be clearly and completely described below with reference to the accompanying drawings, and it is apparent that the described embodiments are some embodiments of the present invention, not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention.
It can be appreciated that the current method for manufacturing a radionuclide applicator suitable for the shape of a lesion of a patient generally drops the prepared radioactive feed liquid on a substrate such as filter paper cut according to the shape and size of the lesion of the patient, and then the radionuclide applicator is obtained after drying and plastic packaging.
In view of the above-mentioned drawbacks, there is also a method for manufacturing an applicator using a 3D printing technique, in which a three-dimensional image of a lesion is scanned, and then a prepared radioactive feed liquid is printed on a substrate according to the three-dimensional image by using the 3D printing technique.
Inkjet printing is a technique that enables the ejection of ink droplets to a receiver to form an image. Since the ink droplets are very fine and closely adjacent, a continuous image is visually seen. In essence, inkjet printing is a technique based on the formation of a planar layer of liquid.
The nuclide carrier for preparing the radionuclide applicator, e.g. phosphorus 32 P]Radioactive component Na in acid sodium salt oral solution 2 H 32 PO 4 Salts which are readily water soluble and which have a solubility in water of 175.9. 175.9 g/100 mL (25 ℃), i.e. a maximum of 1.759g of molecules per ml of water, and radioactive Na 2 H 32 PO 4 The specific activity of (2) is 2.4X10 15 Bq/g, i.e. maximum soluble in water of about 4.2X10 s per ml 15 Radioactivity of Bq 32 P. Thus, by passing Na 2 H 32 PO 4 Is dissolved inIn water, is sufficient to meet the activity requirements of preparing the radionuclide applicator.
Further, inkjet printing is a technique that can eject ink droplets onto a receptor to form an image, and has the advantages of rapidness, good uniformity, low cost, and the like.
Based on the above, the embodiment of the invention provides a method for manufacturing a radionuclide applicator based on an ink-jet printing technology, so as to improve the manufacturing efficiency and quality of the radionuclide applicator and reduce the manufacturing cost.
A method of making a radionuclide applicator according to the invention, which can be performed by software and/or hardware in an electronic device such as a computer, tablet, mobile phone, etc., is described below with reference to fig. 1 to 5, as shown in fig. 1, and comprises the steps of:
101. and acquiring the graph data of the focus, wherein the graph data comprises the contour data of the focus and a reference mark corresponding to the contour.
In this embodiment, the acquired graphic data of the lesion may be acquired in various manners, for example: the image of the focus scanned by the scanning device and the reference mark can be obtained, or the image of the focus shot and the reference mark can be obtained by a mobile phone, a camera and the like.
102. The graphic data is imported into the ink-jet printer, and the scale of the ink-jet printer is adjusted to be matched with the reference mark.
In this embodiment, the reference mark is used to calibrate the scale of the ink-jet printer when the ink-jet printer is used to print the radionuclide applicator that is adapted to the shape and size of the lesion, and thus, the reference mark may be a ruler, vernier caliper, or the like with standard scale placed around the lesion, so as to calibrate the ink-jet printer as a scale, thereby printing the radionuclide applicator that is highly adapted to the shape and size of the lesion.
Thus, in one embodiment of the invention, obtaining graphical data for a lesion includes:
a first target image is acquired, the first target image being an image acquired after placement of fiducial markers on either side of the lesion.
An image of the fiducial marker and the contour data of the lesion is extracted from the first target image as graphics data.
In this embodiment, the first target image may be obtained by acquiring a two-dimensional image of the fiducial markers disposed on either side of the lesion acquired by a scanning device or a camera device such as a cell phone, camera, or the like.
The focus is positioned on the skin of a patient, and the acquired image comprising the reference mark and the focus also comprises human skin, so that contour data of the reference mark and the focus are scratched out of the first target image, and the adaptation degree of the printed shape and the focus when the ink-jet printing is influenced by the color of the skin can be avoided.
Further, in order to improve the contrast between the contour of the lesion and the skin in the acquired image containing the contour data of the lesion, a two-dimensional image acquired after painting the lesion may be acquired.
In a specific embodiment, taking the reference mark as a ruler as an example, the acquired first target image may be as shown in fig. 2, and the image of the ruler and the focus extracted from fig. 2, that is, the graphic data is as shown in fig. 3, and after the scale of the inkjet printer is calibrated based on the scale of the ruler included in fig. 3, the graphic matching the shape and the size of the focus in fig. 2 may be printed by using the inkjet printer.
Further, the acquired graphical data of the lesion may be collected in a variety of ways. In another embodiment of the present invention, obtaining graphical data for a lesion includes:
acquiring a second target image, wherein the second target image is an image acquired after a reference mark is arranged on any side of the shape of a focus of rubbing;
and extracting images of the reference mark and the contour data of the focus from the second target image as graphic data.
In this embodiment, the second target image may be an image taken together with the reference mark after the focus is colored, the focus is covered with a transparent plastic material, the focus is subjected to rubbing, and then the material after the shape of the focus is rubbed is tiled.
In a specific embodiment, taking the reference mark as a ruler as an example, the acquired second target image may be as shown in fig. 4, and then the image of the ruler and the focus extracted in fig. 4, that is, the graphic data, is also as shown in fig. 3, and after the scale of the inkjet printer is calibrated based on the scale of the ruler included in fig. 3, the graphic matching the shape and the size of the focus in fig. 4 may be printed by using the inkjet printer.
103. Controlling an ink-jet printer to print the ink containing the radioactive feed liquid preset according to the focus state on a substrate based on the contour data, so as to obtain a printed substrate;
wherein the printed substrate is molded to form the radionuclide applicator.
In this embodiment, by introducing the profile data into an inkjet printer and then controlling the inkjet printer to inkjet print the ink containing the radioactive liquid on a substrate such as filter paper, a printed substrate having a shape highly adapted to the shape and size of a lesion as shown in fig. 5 and containing thereon a nuclide carrier for treating the lesion can be printed. The radionuclide applicator can be obtained after subsequent plastic packaging of the printed substrate.
In particular, the radionuclide applicators made using the methods provided by embodiments of the present invention, the adapted radionuclides include radionuclides capable of generating beta rays, such as 24 Na、 32 P、 38 Cl、 40 K、 41 Ar、 42 K、 76 As、 86 Ru、 89 Sr、 90 Sr、 90 Y、 106 Ru、 106 Rh、 166 Ho、 177 Lu、 188 Re、 210 Tl, etc., or radionuclides capable of emitting low-energy gamma rays, e.g. 131 I、 125 I、 103 Pd, etc.
Further, the ink in the ink-jet printer needs to be an ink containing a radioactive liquid adapted to the condition of the lesion.
Thus, in one embodiment of the invention, a method of obtaining an ink pre-conditioned with a radioactive feed according to the condition of the lesion is specifically described, namely:
first, a unit ink ejection amount of an ink jet printer is acquired.
Wherein, the unit ink jet amount of the ink jet printer can be determined by the method provided in the following examples, namely:
firstly, acquiring the weight of blank paper, wherein the weight X of the blank paper 0 The weight data obtained by weighing the blank sheet with an analytical balance may be used.
And then printing an image of a unit area on the blank paper based on the ink-jet printer to obtain the printing paper. The unit area may be preset, for example: square of 1cm×1cm, circular with radius of 1cm, etc. After that, the inkjet printer is controlled to print out an image of a unit area on a blank sheet by setting the picture mode, for example, to be full black.
Thereafter, the weight of the printing paper is acquired. Wherein the weight X of the printing paper 1 The weight data obtained by weighing the printing paper with an analytical balance may also be used.
Finally, a unit ink ejection amount of the ink jet printer is determined based on the weight of the blank sheet and the weight of the print sheet. Wherein, (X 1 -X 0 ) I.e., the amount of ink that is required by the ink jet printer to print an image per unit area, i.e., the unit amount of ink ejection.
Thus, after the unit ink jet amount of the ink jet printer is obtained, the amount of the radioactive liquid to be charged in the ink of the ink jet printer can be determined based on the activity requirement of the radionuclide applicator corresponding to the condition of the lesion and the unit ink jet amount.
For example: for 100uCi/cm 2 The radionuclide applicator of (2) has a dosing activity per square centimeter of 100uCi, so that the total radioactive concentration of the ink is 100/(X) 1 -X 0 )uCi/g。
After the feeding amount is determined, adding the radioactive feed liquid into the ink, and uniformly mixing to obtain the ink containing the radioactive feed liquid preset according to the focus condition.
According to the method for manufacturing the radionuclide applicator, provided by the embodiment of the invention, the characteristics of low cost, high efficiency and good uniformity of ink-jet printing are fully utilized in the process of manufacturing the radionuclide applicator by applying the ink-jet printing technology to the radionuclide applicator, so that the manufacturing of the radionuclide applicator is simple and efficient, meanwhile, the ink layer of the manufactured radionuclide applicator can reach the micrometer level, has small thickness and is convenient to be attached to a focus, so that the comfort of a patient is improved, and further, in the process of ink-jet printing, the shape, the size and the height of the printed radionuclide applicator and the focus are adapted through the extracted reference mark and the contour data of the focus, and the treatment effect of the radionuclide applicator manufactured by the method for manufacturing the radionuclide applicator provided by the embodiment of the invention is further improved on the basis of the color change of the focus on the basis of ensuring the small thickness of the radionuclide applicator.
Based on the same general inventive concept, the present invention also protects a radionuclide applicator manufacturing system, the radionuclide applicator manufacturing system provided by the present invention is described below, and the radionuclide applicator manufacturing system described below and the radionuclide applicator manufacturing method described above can be referred to correspondingly with each other.
Fig. 6 is a schematic diagram of the construction of a radionuclide applicator manufacturing system provided by the present invention. As shown in fig. 6, includes: a fiducial mark 610, an image capture device 620, an inkjet printer 630, and a processing terminal 640; wherein,
fiducial markers 610 are used as a dimensional reference for lesions;
the image acquisition device 620 is configured to acquire graphic data of a lesion, where the graphic data includes contour data of the lesion and a reference mark corresponding to the contour;
the inkjet printer 630 is for inkjet printing ink on a substrate based on the imported profile data;
the processing terminal 640 is used for acquiring the graph data of the focus, importing the graph data into an inkjet printer, adjusting the scale of the inkjet printer to be matched with the reference mark, and controlling the inkjet printer to jet ink containing radioactive feed liquid preset according to the status of the focus on the substrate based on the contour data to obtain a printed substrate;
wherein the printed substrate is molded to form the radionuclide applicator.
In the embodiment, the image acquisition equipment acquires the image data of the focus, including the outline data and the reference mark corresponding to the outline, through the processing terminal; the graphic data is imported into an ink-jet printer, and a scale of the ink-jet printer is adjusted to be matched with the reference mark; based on the contour data, controlling the ink-jet printer to print the ink containing the radioactive feed liquid preset according to the focus condition on the substrate by ink-jet, thereby obtaining the printing substrate corresponding to the focus, and forming the radionuclide applicator after plastic packaging the printing substrate. The obtained profile data of the focus and the figure data of the reference mark corresponding to the profile can provide accurate basis for manufacturing the radionuclide applicator corresponding to the focus in shape and size, and then the radionuclide applicator highly attached to the focus in shape and size can be realized by combining an ink jet printing technology.
Based on the foregoing, the radionuclide applicator fabrication system further includes: plastic packaging equipment;
and the plastic packaging equipment is used for plastic packaging the printing substrate to obtain the radionuclide applicator.
In this embodiment, the printed substrate may be molded using plastic such as PE (polyethylene), PET (Polyethylene terephthalate, polyester film), BOPP (Biaxially Oriented Polypropylene, biaxially oriented polypropylene film), or the like.
It can be understood that before the printed substrate is molded, the ink on the printed substrate should be dried by air drying or baking, and then molded.
Optionally, the processing terminal 640 is specifically configured to:
acquiring a first target image, wherein the first target image is an image acquired after a reference mark is arranged on any side of a focus;
an image of the fiducial marker and the contour data of the lesion is extracted from the first target image as graphics data.
Optionally, the processing terminal 640 is specifically configured to:
acquiring a second target image, wherein the second target image is an image acquired after a reference mark is arranged on any side of the shape of a focus of rubbing;
and extracting images of the reference mark and the contour data of the focus from the second target image as graphic data.
Optionally, the processing terminal 640 is further specifically configured to:
acquiring a unit ink jet amount of an ink jet printer;
the amount of radioactive feed in the ink of the ink jet printer is determined based on the activity requirements of the radionuclide applicator corresponding to the condition of the lesion and the unit ink jet amount.
Optionally, the processing terminal 640 is further specifically configured to:
acquiring the weight of blank paper;
controlling an ink-jet printer to print an image of a unit area on blank paper to obtain printing paper;
acquiring the weight of printing paper;
the unit ink ejection amount of the ink jet printer is determined based on the weight of the blank sheet and the weight of the print sheet.
Fig. 7 illustrates a physical schematic diagram of an electronic device, as shown in fig. 7, which may include: processor 710, communication interface (Communications Interface) 720, memory 730, and communication bus 740, wherein processor 710, communication interface 720, memory 730 communicate with each other via communication bus 740. The processor 710 may invoke logic instructions in the memory 730 to perform a method of making a radionuclide applicator, the method comprising: obtaining the graph data of the focus, wherein the graph data comprises the contour data of the focus and a reference mark corresponding to the contour; the graphic data is imported into an ink-jet printer, and a scale of the ink-jet printer is adjusted to be matched with the reference mark; controlling an ink-jet printer to print the ink containing the radioactive feed liquid preset according to the focus state on a substrate based on the contour data, so as to obtain a printed substrate; wherein the printed substrate is molded to form the radionuclide applicator.
Further, the logic instructions in the memory 730 described above may be implemented in the form of software functional units and may be stored in a computer readable storage medium when sold or used as a stand alone product. Based on this understanding, the technical solution of the present invention may be embodied essentially or in a part contributing to the prior art or in a part of the technical solution, in the form of a software product stored in a storage medium, comprising several instructions for causing a computer device (which may be a personal computer, a server, a network device, etc.) to perform all or part of the steps of the method according to the embodiments of the present invention. And the aforementioned storage medium includes: a U-disk, a removable hard disk, a Read-Only Memory (ROM), a random access Memory (RAM, random Access Memory), a magnetic disk, or an optical disk, or other various media capable of storing program codes.
In another aspect, the invention also provides a computer program product comprising a computer program storable on a non-transitory computer readable storage medium, the computer program when executed by a processor being capable of performing the method of making a radionuclide applicator provided by the methods described above, the method comprising: obtaining the graph data of the focus, wherein the graph data comprises the contour data of the focus and a reference mark corresponding to the contour; the graphic data is imported into an ink-jet printer, and a scale of the ink-jet printer is adjusted to be matched with the reference mark; controlling an ink-jet printer to print the ink containing the radioactive feed liquid preset according to the focus state on a substrate based on the contour data, so as to obtain a printed substrate; wherein the printed substrate is molded to form the radionuclide applicator.
In yet another aspect, the present invention provides a non-transitory computer readable storage medium having stored thereon a computer program which when executed by a processor performs a method of fabricating a radionuclide applicator provided by the methods described above, the method comprising: obtaining the graph data of the focus, wherein the graph data comprises the contour data of the focus and a reference mark corresponding to the contour; the graphic data is imported into an ink-jet printer, and a scale of the ink-jet printer is adjusted to be matched with the reference mark; controlling an ink-jet printer to print the ink containing the radioactive feed liquid preset according to the focus state on a substrate based on the contour data, so as to obtain a printed substrate; wherein the printed substrate is molded to form the radionuclide applicator.
The apparatus embodiments described above are merely illustrative, wherein the elements illustrated as separate elements may or may not be physically separate, and the elements shown as elements may or may not be physical elements, may be located in one place, or may be distributed over a plurality of network elements. Some or all of the modules may be selected according to actual needs to achieve the purpose of the solution of this embodiment. Those of ordinary skill in the art will understand and implement the present invention without undue burden.
From the above description of the embodiments, it will be apparent to those skilled in the art that the embodiments may be implemented by means of software plus necessary general hardware platforms, or of course may be implemented by means of hardware. Based on this understanding, the foregoing technical solution may be embodied essentially or in a part contributing to the prior art in the form of a software product, which may be stored in a computer readable storage medium, such as ROM/RAM, a magnetic disk, an optical disk, etc., including several instructions for causing a computer device (which may be a personal computer, a server, or a network device, etc.) to execute the method described in the respective embodiments or some parts of the embodiments.
Finally, it should be noted that: the above embodiments are only for illustrating the technical solution of the present invention, and are not limiting; although the invention has been described in detail with reference to the foregoing embodiments, it will be understood by those of ordinary skill in the art that: the technical scheme described in the foregoing embodiments can be modified or some technical features thereof can be replaced by equivalents; such modifications and substitutions do not depart from the spirit and scope of the technical solutions of the embodiments of the present invention.
Claims (7)
1. A method of making a radionuclide applicator comprising:
obtaining the graph data of a focus, wherein the graph data comprises contour data of the focus and a reference mark corresponding to the contour;
the fiducial marks are used to calibrate the scale of the inkjet printer when the radionuclide applicator that fits the shape and size of the lesion is printed with the inkjet printer;
importing the graphic data into an inkjet printer, and adjusting a scale of the inkjet printer to be matched with the reference mark;
controlling the ink-jet printer to jet ink containing radioactive feed liquid preset according to the focus state on a substrate based on the contour data to obtain a printed substrate;
wherein the printed substrate is plastic encapsulated to form a radionuclide applicator;
wherein the obtaining the graphic data of the focus comprises:
acquiring a first target image, wherein the first target image is an image acquired after the reference mark is arranged on any side of the focus;
extracting an image of the fiducial marker and the contour data of the lesion from the first target image as the graphical data;
wherein, preconditioning the ink containing the radioactive feed liquid according to the condition of the focus comprises:
acquiring a unit ink jet amount of the ink jet printer;
determining a charge of the radioactive feed liquid in ink of the inkjet printer based on an activity requirement of the radionuclide applicator corresponding to a condition of the lesion and the unit inkjet amount;
the obtaining a unit ink jet amount of the ink jet printer includes:
acquiring the weight of blank paper;
controlling the ink-jet printer to print an image of a unit area on the blank paper to obtain printing paper;
acquiring the weight of the printing paper;
the unit ink ejection amount of the ink jet printer is determined based on the weight of the blank sheet and the weight of the print sheet.
2. The method of claim 1, wherein the acquiring the graphical data of the lesion comprises:
acquiring a second target image, wherein the second target image is an image acquired after the reference mark is arranged on any side of the shape of the focus of rubbing;
and extracting an image of the reference mark and the contour data of the focus from the second target image as the graphic data.
3. A system for making a radionuclide applicator, comprising:
fiducial markers for use as a dimensional reference for lesions;
the image acquisition equipment is used for acquiring the graph data of the focus, wherein the graph data comprises the contour data of the focus and the reference mark corresponding to the contour;
the fiducial marks are used to calibrate the scale of the inkjet printer when the radionuclide applicator that fits the shape and size of the lesion is printed with the inkjet printer;
collecting graphical data for a lesion, comprising:
acquiring a first target image, wherein the first target image is an image acquired after the reference mark is arranged on any side of the focus;
extracting an image of the fiducial marker and the contour data of the lesion from the first target image as the graphical data;
an inkjet printer for inkjet printing ink on a substrate based on the imported profile data;
the processing terminal is used for acquiring the graph data of the focus, importing the graph data into the inkjet printer, adjusting the scale of the inkjet printer to be matched with the reference mark, and controlling the inkjet printer to jet ink containing radioactive feed liquid preset according to the condition of the focus on a substrate based on the contour data to obtain a printed substrate;
presetting the ink containing the radioactive feed liquid according to the condition of the focus, wherein the ink comprises the following components:
acquiring a unit ink jet amount of the ink jet printer;
determining a charge of the radioactive feed liquid in ink of the inkjet printer based on an activity requirement of the radionuclide applicator corresponding to a condition of the lesion and the unit inkjet amount;
the obtaining a unit ink jet amount of the ink jet printer includes:
acquiring the weight of blank paper;
controlling the ink-jet printer to print an image of a unit area on the blank paper to obtain printing paper;
acquiring the weight of the printing paper;
determining the unit ink ejection amount of the ink jet printer based on the weight of the blank sheet and the weight of the print sheet;
wherein the printed substrate is plastic encapsulated to form the radionuclide applicator.
4. The radionuclide applicator manufacturing system according to claim 3, further comprising: plastic packaging equipment;
the plastic packaging device is used for plastic packaging the printing substrate to obtain the radionuclide applicator.
5. A radionuclide applicator manufactured using the method of manufacturing a radionuclide applicator according to any of claims 1 to 2 or the system of manufacturing a radionuclide applicator according to claim 3 or 4.
6. An electronic device comprising a memory, a processor and a computer program stored on the memory and executable on the processor, wherein the processor, when executing the program, implements a method of making a radionuclide applicator according to any of claims 1 to 2.
7. A non-transitory computer readable storage medium having stored thereon a computer program, which when executed by a processor, implements a method of fabricating a radionuclide applicator according to any of claims 1 to 2.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202311341265.3A CN117067796B (en) | 2023-10-17 | 2023-10-17 | Method and system for manufacturing radionuclide applicator, applicator and electronic equipment |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202311341265.3A CN117067796B (en) | 2023-10-17 | 2023-10-17 | Method and system for manufacturing radionuclide applicator, applicator and electronic equipment |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN117067796A CN117067796A (en) | 2023-11-17 |
| CN117067796B true CN117067796B (en) | 2024-01-16 |
Family
ID=88715690
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202311341265.3A Active CN117067796B (en) | 2023-10-17 | 2023-10-17 | Method and system for manufacturing radionuclide applicator, applicator and electronic equipment |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN117067796B (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN117724145B (en) * | 2024-02-07 | 2024-05-14 | 原子高科股份有限公司 | Method and device for acquiring activity of planar applicator, electronic equipment and storage medium |
| CN118512706A (en) * | 2024-05-24 | 2024-08-20 | 华中科技大学 | Manufacturing method of nuclide application patch for treatment |
Citations (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0730873A1 (en) * | 1995-03-07 | 1996-09-11 | Korea Atomic Energy Research Institute | A radioactive patch/film and process for preparation thereof |
| CN103026525A (en) * | 2010-07-26 | 2013-04-03 | 默克专利有限公司 | Nanocrystals in devices |
| CN106529429A (en) * | 2016-10-27 | 2017-03-22 | 中国计量大学 | Image recognition-based facial skin analysis system |
| CN110293684A (en) * | 2019-06-03 | 2019-10-01 | 深圳市科迈爱康科技有限公司 | Dressing Method of printing, apparatus and system based on three-dimensional printing technology |
| CN110339470A (en) * | 2019-07-03 | 2019-10-18 | 华中科技大学同济医学院附属协和医院 | A kind of applicator preparation method and system |
| CN111544605A (en) * | 2020-05-12 | 2020-08-18 | 太阳雨林（厦门）生物医药有限公司 | Carrier sheet for loading radioactive iodine 125 particles and preparation method thereof |
| CN111902165A (en) * | 2018-03-07 | 2020-11-06 | 马金-克利尔私人有限公司 | Local brachytherapy device and method of treating malignant cancer cells |
| CN112384195A (en) * | 2018-07-25 | 2021-02-19 | 凸版印刷株式会社 | Film for skin application and transfer sheet |
| CN115475323A (en) * | 2022-09-16 | 2022-12-16 | 武汉市中心医院 | Nuclide application based on 3D printing and preparation method |
| CN116650852A (en) * | 2023-08-01 | 2023-08-29 | 原子高科股份有限公司 | Radionuclide applicator based on 3D printing and preparation method thereof |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2002320088A1 (en) * | 2001-06-13 | 2002-12-23 | Marc G. Apple | Brachytherapy device and method |
-
2023
- 2023-10-17 CN CN202311341265.3A patent/CN117067796B/en active Active
Patent Citations (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0730873A1 (en) * | 1995-03-07 | 1996-09-11 | Korea Atomic Energy Research Institute | A radioactive patch/film and process for preparation thereof |
| CN103026525A (en) * | 2010-07-26 | 2013-04-03 | 默克专利有限公司 | Nanocrystals in devices |
| CN106529429A (en) * | 2016-10-27 | 2017-03-22 | 中国计量大学 | Image recognition-based facial skin analysis system |
| CN111902165A (en) * | 2018-03-07 | 2020-11-06 | 马金-克利尔私人有限公司 | Local brachytherapy device and method of treating malignant cancer cells |
| CN112384195A (en) * | 2018-07-25 | 2021-02-19 | 凸版印刷株式会社 | Film for skin application and transfer sheet |
| CN110293684A (en) * | 2019-06-03 | 2019-10-01 | 深圳市科迈爱康科技有限公司 | Dressing Method of printing, apparatus and system based on three-dimensional printing technology |
| CN110339470A (en) * | 2019-07-03 | 2019-10-18 | 华中科技大学同济医学院附属协和医院 | A kind of applicator preparation method and system |
| CN111544605A (en) * | 2020-05-12 | 2020-08-18 | 太阳雨林（厦门）生物医药有限公司 | Carrier sheet for loading radioactive iodine 125 particles and preparation method thereof |
| CN115475323A (en) * | 2022-09-16 | 2022-12-16 | 武汉市中心医院 | Nuclide application based on 3D printing and preparation method |
| CN116650852A (en) * | 2023-08-01 | 2023-08-29 | 原子高科股份有限公司 | Radionuclide applicator based on 3D printing and preparation method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN117067796A (en) | 2023-11-17 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN117067796B (en) | Method and system for manufacturing radionuclide applicator, applicator and electronic equipment | |
| US11872766B2 (en) | System and method for additive manufacturing of an object | |
| EP3274172B1 (en) | Method and system for in situ sintering of conductive ink | |
| US20110172517A1 (en) | Method for determining information used as the basis for calculating a radiotherapy treatment plan and combined magnetic resonance imaging/pet device | |
| DE102013218724B4 (en) | Systems and methods for ink-based digital printing using liquid dip development | |
| Gallivanone et al. | A fully automatic, threshold-based segmentation method for the estimation of the metabolic tumor volume from PET images: validation on 3D printed anthropomorphic oncological lesions | |
| Zhang et al. | Fabrication of an anthropomorphic heterogeneous mouse phantom for multimodality medical imaging | |
| CN103228213B (en) | For monitoring the method for dose of radiation | |
| CN115131376A (en) | Voxel combination method and related device | |
| CN116650852B (en) | Radionuclide applicator based on 3D printing and preparation method thereof | |
| CN110290833A (en) | For applying the model radiated, the method for making the model and the purposes of the model | |
| US8253120B2 (en) | Flood source with pigmentless active area and visible border | |
| CN104979523B (en) | Light sheet material manufacturing method, plate of battery manufacturing device with coating material | |
| EP3735932A1 (en) | Patient marker | |
| CN110339470A (en) | A kind of applicator preparation method and system | |
| CN107198833A (en) | The fast accurate image-forming assembly and method of proton CT system | |
| CN208881181U (en) | 3 D-printing device | |
| Soffientini et al. | A new zeolite PET phantom to test segmentation algorithms on heterogeneous activity distributions featured with ground‐truth contours | |
| JP2003532872A (en) | Radioactive flood source and method of manufacturing the same | |
| Ikejimba et al. | Hyperia: A novel methodology of developing anthropomorphic breast phantoms for X‐ray imaging modalities–Part I: Concept and initial findings | |
| KR20220034197A (en) | fair | |
| CN103353992B (en) | A kind of unmarked automatic positioning method of film | |
| CN101730372A (en) | Method and system for modulating bulb tube current | |
| CN202182947U (en) | Irradiation indicating card | |
| Liu et al. | Dose estimation of animal experiments at the THOR BNCT beam by NCTPlan and Xplan |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |