CN116617106A - Protopanaxatriol saponin allergy-relieving repairing composition, and preparation method and application thereof - Google Patents
Protopanaxatriol saponin allergy-relieving repairing composition, and preparation method and application thereof Download PDFInfo
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- CN116617106A CN116617106A CN202310553576.XA CN202310553576A CN116617106A CN 116617106 A CN116617106 A CN 116617106A CN 202310553576 A CN202310553576 A CN 202310553576A CN 116617106 A CN116617106 A CN 116617106A
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- skin
- saponin
- protopanaxatriol
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- repairing
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- QYDYPVFESGNLHU-KHPPLWFESA-N methyl oleate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OC QYDYPVFESGNLHU-KHPPLWFESA-N 0.000 description 1
- 229940073769 methyl oleate Drugs 0.000 description 1
- ZSIAUFGUXNUGDI-UHFFFAOYSA-N n-hexyl alcohol Natural products CCCCCCO ZSIAUFGUXNUGDI-UHFFFAOYSA-N 0.000 description 1
- 231100000344 non-irritating Toxicity 0.000 description 1
- LLPWNQMSUYAGQI-UHFFFAOYSA-N notoginsenoside r1 Chemical compound C1CC(C2(CC(C3C(C)(C)C(O)CCC3(C)C2CC2O)OC3C(C(O)C(O)C(CO)O3)OC3C(C(O)C(O)CO3)O)C)(C)C2C1C(C)(CCC=C(C)C)OC1OC(CO)C(O)C(O)C1O LLPWNQMSUYAGQI-UHFFFAOYSA-N 0.000 description 1
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- 231100000719 pollutant Toxicity 0.000 description 1
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- 150000003077 polyols Chemical class 0.000 description 1
- 230000008569 process Effects 0.000 description 1
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- 229940057910 shea butter Drugs 0.000 description 1
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- 208000017520 skin disease Diseases 0.000 description 1
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- CCOQPGVQAWPUPE-KYZUINATSA-N trans4-tert-butylcyclohexan-1-ol Chemical compound CC(C)(C)[C@H]1CC[C@H](O)CC1 CCOQPGVQAWPUPE-KYZUINATSA-N 0.000 description 1
- 229940045136 urea Drugs 0.000 description 1
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- 230000029663 wound healing Effects 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/63—Steroids; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/42—Amides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
- A61K8/602—Glycosides, e.g. rutin
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/005—Preparations for sensitive skin
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
- A61K2800/30—Characterized by the absence of a particular group of ingredients
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
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- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
- A61K2800/78—Enzyme modulators, e.g. Enzyme agonists
- A61K2800/782—Enzyme inhibitors; Enzyme antagonists
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Abstract
The application relates to a protopanaxatriol saponin allergy-relieving repairing composition, which comprises the following components: 0.05-2 parts of protopanaxatriol saponin; 0.05-2 parts of dipotassium glycyrrhizinate; 0.1-5 parts of panthenol; 0.2-5 parts of xylitol-based glucoside (AQUAXYL); 30-70 parts of polyalcohol; 20-50 parts of water. The composition of the application does not add any preservative or solubilizer, has high safety, is mild and has no stimulation, is especially suitable for sensitive skin, can relieve and improve the stimulation state of the sensitive skin from various ways, and can repair the damaged skin barrier, thereby fundamentally solving the problem of skin allergy.
Description
Technical Field
The application relates to the technical field of skin care products, in particular to a protopanaxatriol saponin allergy-relieving repairing composition, a preparation method and application thereof.
Background
Modern life is continuously accelerated, working pressure is high, diet is irregular, medical projects are transited, skin care is inappropriately carried out, environmental pollution such as PM2.5/PM10, sulfides, nitrogen oxides, ozone and other pollutants is carried out, human skin is influenced by internal and external bad factors, a series of inflammatory reactions are generated, the skin initially forms clinical symptoms such as redness, stinging, itching and the like, under repeated stimulation, the skin cuticle is further thinned, the skin barrier is damaged, skin sensitivity is accelerated, and a series of problems such as dryness, roughness, color spots, wrinkles and the like are caused to the skin.
Data from the consensus of Chinese sensitive skin diagnosis and treatment specialists show that 40% -56% of Asian women are sensitive muscles. The sensitive skin has damaged skin barrier, and under the influence of adverse factors, the secretion of inflammatory factors is easily stimulated, and the aggregation of the inflammatory factors can cause the symptoms of vasodilation, redness, stinging and itching. The skin care product is a main technical path of skin care products with sensitive muscle efficacy, can quickly relieve skin irritation, repair skin barrier and strengthen skin tolerance.
CN114129497a provides a composition with anti-allergic, soothing and skin-repairing effects and its use. The composition comprises the following components in parts by mass: 0.55-3 parts of candida melissa/glucose/rapeseed methyl oleate fermentation product, 0.006-0.08 parts of yarrow extract, 0.8-3 parts of gentian extract and 0.2-3 parts of oat kernel extract. The composition of the application can improve the stability of skin feel, grease and active substances, increase the affinity and absorbability of skin, and has excellent effects of resisting oxidation, resisting sensitization, resisting inflammation, repairing skin and the like.
CN113116782B discloses an anti-allergic repair composition, a preparation method and application thereof. The anti-allergy repair composition comprises the following components in parts by mass: 0.31-0.49 parts of skin conditioner; 0.27-0.39 parts of antioxidant; 0.04-0.06 parts of omega 6 ceramide; biological sugar gum-1.04-0.06 parts; the antioxidant comprises at least Olibanum extract; the preparation method comprises the following steps: adding skin conditioner, antioxidant, omega 6 ceramide and biological glycon-1 into a container, and stirring to obtain the antiallergic repairing composition. The composition can be added into cosmetic water, cream, facial mask and essence, has the effects of better repairing skin redness and itching, promotes cell repair, greatly improves skin redness and itching, and has the advantages of removing red blood streaks, repairing skin barriers and removing acnes.
CN112569151a discloses an anti-allergic repair barrier composition, a preparation method and application thereof. The anti-sensitization repair barrier composition comprises the following components in percentage by weight: 0.1 to 20 percent of oligopeptide-1; 0.1-50% of centella asiatica extract; 0.1 to 30 percent of phoenix single-cluster tea volatile oil; 0.1 to 20 percent of trans-4-tertiary butyl cyclohexanol; 0.1 to 20 percent of ceramide 2 liposome; 0.1 to 10 percent of low molecular weight sodium hyaluronate; 0.1 to 10 percent of high molecular weight sodium hyaluronate; urea 0.1-10%; and the balance of deionized water. Oligopeptide-1, herba Centellae extract, phoenix single tea volatile oil, trans-4-tert-butyl hexanol, ceramide 2, sodium hyaluronate, urea, etc., can relieve skin sensitivity, repair skin barrier, and resist inflammation.
The formation and pathogenesis of sensitive skin are complex, and the development of the existing sensitive muscle crowd nursing products mainly selects anti-inflammatory efficacy components to block inflammation, can only relieve the basic problem of sensitive skin, and can not deeply repair and improve damaged skin. The multifunctional components with complementary action mechanisms are selected for compounding, so that the allergic skin can be relaxed and repaired from deep layers. Moreover, because the skin of sensitive people is fragile, the formula and raw materials of the skin care product are as mild as possible, and the use of antiseptics, pigments and other irritating raw materials is reduced.
Disclosure of Invention
The application aims to solve the problems and provide a protopanaxatriol saponin allergy-relieving repairing composition, a preparation method and application thereof. The protopanaxatriol saponin allergy-relieving repair composition provided by the application has the advantages of synergistic interaction, capability of effectively relieving skin stinging, relieving and improving skin irritation state, capability of repairing skin barrier, mildness, safety and no irritation to human body.
The aim of the application is achieved by the following technical scheme:
a protopanaxatriol saponin allergy-relieving repairing composition comprises the following components:
wherein the protopanaxatriol saponin comprises at least one of protopanaxatriol saponin prepared from radix Ginseng or stem and leaf, radix Panacis Quinquefolii or stem and leaf, and radix Notoginseng.
Preferably, the polyol is at least one selected from butanediol, propylene glycol, glycerol, pentanediol and hexanediol.
Preferably, the composition consists of the following components:
further preferably, the composition consists of the following components:
preferably, the preparation method of the protopanaxatriol saponin sensitivity-relieving repairing composition comprises the following steps of: mixing panaxatriol saponin, dipotassium glycyrrhizinate, panthenol, xylitol-based glucoside (AQUAXYL), polyalcohol and water under stirring at 30-60deg.C, and filtering to obtain protopanaxatriol saponin allergy relieving composition.
The application of the protopanaxatriol saponin allergy relieving and repairing composition in preparing skin care cosmetics is that the skin care composition is used for preparing cosmetics or skin care products, and comprises emulsion, cream, smoothing toner, mask and spray.
The cosmetic contains protopanaxatriol saponin with weight percentage of 3-10wt%.
The protopanaxatriol saponin comprises protopanaxatriol saponin prepared from radix Ginseng, stems and leaves, radix Panacis Quinquefolii, stems and leaves, and radix Notoginseng. The preparation process comprises the following steps: one of ginseng root or stem leaf, american ginseng root or stem leaf and notoginseng root is treated through D101 type or AB8 macroporous adsorption resin column, eluting with 8-10 times of water to colorless, eluting with 3-5 times of 25-45% alcohol, collecting the eluent, and concentrating to obtain protopanaxatriol saponin. Wherein the original panaxatriol saponin prepared from radix Ginseng, stems and leaves, and radix Panacis Quinquefolii contains ginsenoside Re and Rg1; the protopanaxatriol saponin prepared from Notoginseng radix root mainly contains ginsenoside Re, rg1 and R1. The protopanaxatriol saponin has the functions of inhibiting the expression of TARC/CCL17 induced by TNFa/IFN-g, inhibiting the increase of a large amount of DAG and the release of histamine by a phosphatidylcholine-PLD system, and has remarkable anti-inflammatory and anti-allergic effects. In addition, the protopanaxatriol saponin has a protective effect on skin fibroblast injury caused by ultraviolet rays, and can promote skin fibroblast proliferation and collagen secretion, thereby having an anti-aging effect.
Dipotassium glycyrrhizinate (purchased from maifu biological products limited company in Zhang Jiang Baoqu, kong) can reduce the secretion level of inflammatory factors, reduce inflammatory reaction, relieve skin discomfort reaction by reducing the blood vessel endothelial growth factor secretion level and down regulating the expression of capsaicin receptor and cyclooxygenase mRNA, reduce the release of granulocytes, promote the proliferation of fibroblasts and quickly repair damaged skin.
Xylitol-based glucoside AQUAXYL (available from SEPPIC S.A.) is a 100% natural saccharide complex with good moisture-retaining and skin barrier-enhancing capabilities. Xylitol glucoside not only directly shows the moisturizing function, but also has the function of assisting in promoting synthesis of ceramide, which is a key component for playing the skin barrier function.
Panthenol (commercially available) is a deep penetrating humectant, and can stimulate the growth of epidermal cells, and is easily absorbed and penetrated into the horny layer on the skin surface. Panthenol is commonly used for moisturizing, but he can also help wound healing, reduce skin irritation, significantly improve skin barrier function, promote epidermal regeneration by enhancing epidermal differentiation and lipid synthesis.
Compared with the prior art, the application has the following beneficial effects:
the application mainly starts from four aspects of regulating water circulation, resisting inflammation and allergy and repairing skin barrier, small molecular panthenol and xylitol-based glucoside permeate epidermis stratum corneum, prevent dehydration, promote water circulation, protect skin barrier, and dipotassium glycyrrhizinate and original panaxatriol saponin have obvious effects of resisting inflammation, resisting allergy, easing pain, resisting oxidation and repairing skin. The composition fully plays roles of soothing and repairing through synergistic effect, and has remarkable effects of calming, soothing and repairing skin; no preservative, pigment, solubilizer and the like are added, so that the application of the active substances is convenient, the skin-friendly emulsion is mild and non-irritating, and the skin-friendly emulsion is friendly to sensitive skin.
Detailed Description
The following description of the technical solutions in the embodiments of the present application will be clear and complete, and it is obvious that the described embodiments are only some embodiments of the present application, but not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the application without making any inventive effort, are intended to be within the scope of the application.
Examples and comparative examples
Examples 1-7 and comparative examples 1-4 provide a protopanaxatriol saponin sensitivity-soothing and repairing composition and a preparation method thereof, wherein each component and content of the sensitivity-soothing and repairing composition are shown in table 1. The preparation method of the comfort and repair composition comprises the following steps:
one of ginseng root or stem leaf, american ginseng root or stem leaf and notoginseng root is treated through D101 type or AB8 macroporous adsorption resin column, eluting with 8-10 times of water until colorless, eluting with 3-5 times of column volume of 25% -45% alcohol, collecting eluent, concentrating to obtain thin extract, and adding dipotassium glycyrrhizinate, panthenol, xylitol-based glucoside (AQUAXYL), butanediol and rest water successively to obtain the final product.
TABLE 1 mixture ratio of Shumin composition (mass percent)
Example 4
This example is substantially identical to the allergy-relieving and repairing composition of example 1 in that the total saponin extract of ginseng stem and leaf is used for preparing protopanaxatriol saponin in example 1, and the total saponin extract of ginseng root is used for preparing protopanaxatriol saponin in this example.
Example 5
The present example is substantially the same as the allergy-relieving and repairing composition of example 1, except that the protopanaxatriol saponin is prepared by using the total saponin extract of the stems and leaves of American ginseng in this example.
Example 6
This example is substantially identical to the allergy-relieving and repairing composition of example 1 and its preparation method, except that the extract of total saponins of American ginseng root is used for preparing protopanaxatriol saponin.
Example 7
This example is substantially identical to the allergy-relieving and repairing composition of example 1, except that the extract of Panax notoginseng root total saponins is used to prepare protopanaxatriol saponins.
Antiallergic efficacy detection
Taking RBL-2H3 cells in a logarithmic growth phase, inoculating the RBL-2H3 cells into a 24-well plate, growing for 48 hours, discarding a cell culture solution, adding a culture medium containing the comfort maintenance composition in the example or the comparative example, setting the culture medium as a treatment group, adding a PBS solution as a blank pair, culturing for 12 hours, adding C48/80, continuously incubating for 1 hour, stopping the reaction in an ice bath for 10 minutes, staining placental blue, and calculating the degranulation rate of the cells.
TABLE 2 detection results of cell degranulation rate
As can be seen from the results in Table 2, the cell degranulation rate of the examples 1-7 with the addition of the protopanaxatriol saponins prepared from different sources is obviously reduced compared with that of the blank group, which indicates that the protopanaxatriol saponins prepared from different sources have better anti-sensitization effect. The cell degranulation rates of comparative examples 1-4 are all improved compared with those of examples 1-7, and the anti-allergic effects of examples 1-7 are stronger than those of comparative examples 1-4, which shows that the combination of protopanaxatriol saponin, dipotassium glycyrrhizinate, panthenol and xylitol-based glucoside (AQUAXYL) has a synergistic effect in anti-allergic aspect, and the composition lacking any active ingredient can reduce the anti-allergic capability of the composition.
Application examples and application comparative examples
Since examples 1 to 7 were superior in anti-sensitization, example 1 was selected for comparison of application effects with comparative examples 1 to 4. The above prepared allergy-relieving repairing composition, example 1 and comparative examples 1-4, were added as raw material components to an essential emulsion, and the specific formulation proportions (weight percentage) are as follows: 5% of protopanaxatriol saponin sensitivity-relieving repairing composition, 4% of butanediol, 1000.5% of oliem, 1% of butter fruit, 3% of caprylic/capric triglyceride, 2% of squalane, 0.15% of carbomer U, 0.2% of arginine, 0.05% of EDTA disodium, 0.4% of 1, 2-hexanediol, 0.4% of p-hydroxyacetophenone and the balance of water.
The preparation method of the allergy-relieving repair essence emulsion comprises the following steps:
(1) Adding carbomer U21, butanediol, EDTA disodium and water into a stirring pot, stirring and heating to 80-85 ℃, and continuously stirring to completely and uniformly mix the materials;
(2) Adding oliem 1000, shea butter, caprylic/capric triglyceride and squalane into an oil pot, stirring and heating to 80-85 ℃ to ensure that the oil phase is completely and uniformly mixed;
(3) Adding the mixed solution B into the mixed solution A, homogenizing and stirring, and adjusting the pH of the material by using an arginine water solution when the temperature is reduced to 60-65 ℃; stirring continuously, and adding p-hydroxyacetophenone, 1,2 hexanediol, and protopanaxatriol saponin sensitivity-relieving composition sequentially when the temperature is reduced to below 50deg.C.
Various embodimentsThe effect of the allergy-relieving repair essence emulsion prepared by the comparative example is verified as follows:
randomly selecting skin health, no skin disease allergy history, and meeting the volunteer selection standard population of the subjects, wherein each sample is 10 people; age distribution: between 18 and 60 years of age. The subjects cleaned their faces with dry paper towels and were sitting still in a laboratory at a temperature of 21±1 ℃ for 30min at 50% ±10% rh; lactic acid stinging test, namely cleaning the face of a subject by using dry paper towel, dripping 50ul of 10% lactic acid on single-layer filter paper with the diameter of 0.8cm, placing the filter paper on the nasal and labial sulcus of the subject, inquiring the stinging sensation of the subject and observing skin reaction at 30s, 2.5min and 5min respectively, and grading from 0 to 3 according to no, light, medium and severe stinging, wherein the total fraction of the lactic acid stinging test is more than or equal to 3, and the positive lactic acid stinging reaction can be selected. And (5) collecting skin basic value data of the subject, namely measuring relevant indexes of the observed part of the subject by using an experiment technician operation Mexameter, colorimeter, tewameter, corneomete.
Table 3 application example efficacy evaluation results
As can be seen from table 3, the improvement of the percutaneous water loss TEWL value, the skin heme Erythema value, the skin color a value, and the lactic acid stinging score was more remarkable in application example 1 than in application comparative examples 1 to 4. The protopanaxatriol saponin, dipotassium glycyrrhizinate, panthenol and xylitol-based glucoside (AQUAXYL) are mutually matched, and have synergistic effect in the aspects of comfort and repair.
Application examples and comparative examples safety test
Human skin patch test: the selected area is not more than 50mm 2 A1 mm deep plaque tester places the test object into the plaque tester chamber with an amount of about 0.020g-0.025g emulsion. When the test substance is a cosmetic product original substance, the control hole is blank (without any substance), and when the test substance is a diluted cosmetic, the diluent of the cosmetic is used in the control hole. Applying the patch test with the test substance to the test site of the subject with hypoallergenic tapeLasting for 24 hours; skin reactions were observed at 0.5h (after the disappearance of the indentations) and recorded at 24h, 48h, respectively.
TABLE 4 skin response grading Standard for skin seal Patch test
TABLE 5 human safety test results
| Sample numbering | 0.5h | 24h | 48h | Results |
| Example 1 | 0 | 0 | 0 | No positive reaction was observed in 30 persons at 1-4 level |
| Comparative example 1 | 0 | 0 | 0 | No positive reaction was observed in 30 persons at 1-4 level |
| Comparative example 2 | 0 | 0 | 0 | No positive reaction was observed in 30 persons at 1-4 level |
| Comparative example 3 | 0 | 0 | 0 | No positive reaction was observed in 30 persons at 1-4 level |
| Comparative example 4 | 0 | 0 | 0 | No positive reaction was observed in 30 persons at 1-4 level |
From the results of table 5, it is understood that the essence emulsions prepared in application example 1 and comparative examples 1 to 4 passed the safety test of human body patches. The composition of the application has high safety, mildness and no stimulation by adding butanediol without adding any preservative or solubilizer, and is convenient for practical operation and application in the process of producing cosmetics.
The previous description of the embodiments is provided to facilitate a person of ordinary skill in the art in order to make and use the present application. It will be apparent to those skilled in the art that various modifications can be readily made to these embodiments and the generic principles described herein may be applied to other embodiments without the use of the inventive faculty. Therefore, the present application is not limited to the above-described embodiments, and those skilled in the art, based on the present disclosure, should make improvements and modifications without departing from the scope of the present application.
Claims (7)
1. The protopanaxatriol saponin allergy-relieving repairing composition is characterized by comprising the following components:
2. a protopanaxatriol saponin sensitivity-relieving and repairing composition according to claim 1, wherein said protopanaxatriol saponin comprises at least one protopanaxatriol saponin prepared from ginseng root or stem, american ginseng root or stem and leaf, or notoginseng root.
3. The protopanaxatriol saponin-sensitivity-restoring composition according to claim 1, wherein the polyalcohol is at least one selected from the group consisting of butanediol, propanediol, glycerol, pentanediol, and hexanediol.
4. The protopanaxatriol saponin-sensitivity-relieving and repairing composition according to claim 1, wherein the composition comprises the following components:
5. a method for preparing a protopanaxatriol saponin sensitivity-enhancing repair composition according to any one of claims 1-4, comprising the steps of:
mixing protopanaxatriol saponin, dipotassium glycyrrhizinate, panthenol, xylitol-based glucoside, polyalcohol and water under stirring at 30-60deg.C, and filtering to obtain protopanaxatriol saponin composition for repairing skin.
6. Use of a protopanaxatriol saponin sensitivity-soothing and repairing composition according to any one of claims 1-4 for the preparation of a sensitivity-soothing and repairing cosmetic, wherein the sensitivity-soothing and repairing composition is used for the preparation of a cosmetic or skin care product, including emulsions, creams, lotions, masks, sprays.
7. The use according to claim 6, wherein the cosmetic protopanaxatriol saponin-sensitive repair composition is added in an amount of 3-10wt%.
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN117323270A (en) * | 2023-11-29 | 2024-01-02 | 江西康一参生物科技有限公司 | Anti-inflammatory multifunctional ginseng composition and application thereof |
-
2023
- 2023-05-17 CN CN202310553576.XA patent/CN116617106A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN117323270A (en) * | 2023-11-29 | 2024-01-02 | 江西康一参生物科技有限公司 | Anti-inflammatory multifunctional ginseng composition and application thereof |
| CN117323270B (en) * | 2023-11-29 | 2024-03-19 | 江西康一参生物科技有限公司 | Anti-inflammatory multifunctional ginseng composition and application thereof |
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