CN116351583A

CN116351583A - Centrifugal device and control method thereof

Info

Publication number: CN116351583A
Application number: CN202310298022.XA
Authority: CN
Inventors: 王小锐; 吴涛; 昌雄; 许腾; 李永军
Original assignee: Beijing Weiyuan Medical Laboratory Co ltd; Guangzhou Vision Gene Technology Co ltd; Guangzhou Weiyuan Intelligent Manufacturing Technology Co ltd; Guangzhou Weiyuan Medical Laboratory Co ltd; Guangzhou Weiyuan Medical Technology Co ltd; Nanjing Weiyuan Medical Laboratory Co ltd; Shenzhen Weiyuan Medical Technology Co ltd; Weiyuan Shenzhen Medical Research Center Co ltd; Guangzhou Weiyuan Medical Equipment Co ltd
Current assignee: Beijing Weiyuan Medical Laboratory Co ltd; Guangzhou Vision Gene Technology Co ltd; Guangzhou Weiyuan Intelligent Manufacturing Technology Co ltd; Guangzhou Weiyuan Medical Equipment Co ltd; Guangzhou Weiyuan Medical Laboratory Co ltd; Guangzhou Weiyuan Medical Technology Co ltd; Shenzhen Weiyuan Medical Technology Co ltd
Priority date: 2023-03-23
Filing date: 2023-03-23
Publication date: 2023-06-30

Abstract

The invention relates to a centrifugal device and a control method thereof, and belongs to the technical field of detection equipment. The centrifugal assembly comprises a bottom plate, a turntable, a motor, a supporting piece and a suspension, wherein the motor and the supporting piece are both fixed on the bottom plate, the turntable is connected with the output end of the motor, a positioning piece and a centrifugal tube cavity are arranged on the suspension, the suspension is hinged with the turntable and can rotate around the plane of the turntable, the suspension is provided with a centrifugal state position and a stop state position, when the suspension is positioned in the centrifugal state position, the cavity axis of the suspension is parallel to the plane of the turntable under the action of centrifugal force, and when the suspension is positioned in the stop state position, the cavity axis of the suspension is perpendicular to the plane of the turntable; and the positioning assembly comprises a positioning magnetic part, wherein the positioning magnetic part is fixed on the supporting part, and when the suspension is positioned in the stop state, the positioning magnetic part is opposite to and attracted with the positioning part. The centrifugal device has an accurate positioning function on the centrifugal station, is favorable for accurately grabbing samples by a subsequent program in an automatic process, and can be integrated into automatic equipment.

Description

Centrifugal device and control method thereof

Technical Field

The invention relates to the technical field of detection equipment, in particular to a centrifugal device and a control method thereof.

Background

With the rapid development of science and technology, laboratories such as biology, chemistry, environment, medicine research and development, foods, etc., and units such as hospitals, disease control, blood stations, etc. have requirements for molecular biological detection of biological samples, environmental samples, etc. In some specific biological experiments, it is necessary to centrifuge the original sample, or a dilution of the treated sample.

At present, the working flow of the conventional centrifuge during working is as follows: after the sample is manually placed, the sample solution is centrifuged by high-speed rotation under the output action of the motor.

In some special situations, especially when the automation equipment is integrated, the operation of the conventional centrifuge is inconvenient, mainly because the position of the conventional centrifuge after the centrifugation is finished and the position at which the conventional centrifuge starts to be put in are changed, that is, the stop position and the station before the start are misplaced, so that the follow-up procedure in the automation flow is difficult to grasp samples according to the position of the samples before the centrifugation, and the follow-up procedure is difficult to integrate into the automation equipment.

Disclosure of Invention

Based on this, it is necessary to provide a centrifugal device having an accurate positioning function for the centrifugal station, which is beneficial for the subsequent procedure in the automated process to be able to accurately grasp the sample, and which can be integrated into the automated equipment.

The invention discloses a centrifugal device, comprising:

the centrifugal assembly comprises a bottom plate, a turntable, a motor, a supporting piece and a suspension, wherein the motor and the supporting piece are both fixed on the bottom plate, the turntable is connected with the output end of the motor and is rotatably fixed on the supporting piece, the suspension is provided with a positioning piece and a tube cavity for placing a centrifugal tube, the suspension is hinged with the turntable and can rotate around the plane of the turntable to enable the suspension to have a centrifugal state position and a stop state position, when the suspension is positioned in the centrifugal state position, the tube cavity axis of the suspension is parallel to the plane of the turntable, and when the suspension is positioned in the stop state position, the tube cavity axis of the suspension is perpendicular to the plane of the turntable; and

the positioning assembly comprises a positioning magnetic piece, wherein the positioning magnetic piece is fixed on the supporting piece, and when the suspension is positioned in the stop state position, the positioning magnetic piece is opposite to the positioning piece and attracts the positioning piece.

The inventor finds that in the prior research and development process, in the conventional centrifugal equipment, after the high-speed centrifugation of the motor is completed, the motor is powered off, but in fact, the mechanical structure is gradually stopped, and the process is an open-loop and uncontrolled process, so that the station of the centrifugal machine cannot accurately position and stop. However, in the automatic equipment, if the accurate position of the station of the equipment cannot be determined, equipment failure is caused, that is, the conventional centrifugal equipment is difficult to apply to the fully automatic equipment.

According to the centrifugal device, the suspension for placing the centrifugal tube is hinged with the turntable, centrifugal force and self gravity of the suspension are ingeniously utilized, the suspension naturally sags in a static state, and the suspension is attracted by magnetic force to fix the position, so that accurate positioning is realized; when in a centrifugal state, the motor is used for outputting power, so that the suspension is rotated and is parallel to the turntable under the action of centrifugal force, and the suspension is far away from the positioning magnetic piece, namely, the positioning attractive force is relieved, and the normal centrifugal flow without interference is realized.

The centrifugal device is exquisite and compact in design, simple and low-cost component equipment is utilized, the purpose of stopping automatic positioning of the centrifugal device is skillfully realized on the premise that the volume of the centrifugal device is not increased, and the centrifugal device can accurately position the equipment station and can be applied to full-automatic equipment.

In one embodiment, the positioning member is disposed at the bottom of the suspension, the positioning magnetic member is fixed on the supporting member through a mounting plate, and the mounting plate is disposed below the suspension. The locating piece is arranged at the bottom of the suspension, the suspension naturally sags and the distance between the positions of the locating piece when the suspension is parallel to the turntable is large, and the suspension is favorably switched between different state positions.

In one embodiment, the positioning assembly further comprises an adjusting plate, a vertical fixing piece and a horizontal fixing piece, the adjusting plate is provided with a vertical installation strip and a horizontal installation strip, the vertical installation strip is provided with a strip-shaped vertical adjusting hole, the horizontal installation strip is provided with a strip-shaped horizontal adjusting hole, the vertical fixing piece penetrates through the vertical adjusting hole to fix the adjusting plate on the supporting piece, and the horizontal fixing piece penetrates through the horizontal adjusting hole to fix the mounting plate on the adjusting plate.

Because of certain difference of magnetic field force of the magnets, the stability effect of installation of corresponding stations of different suspensions on the turntable is consistent; the adjustable plate is provided with a vertical adjusting hole and a horizontal adjusting hole with adjusting function, which are used for adjusting the horizontal position and the height of the positioning magnetic piece, thereby ensuring the stability and the consistency of the centrifugal device.

And the design of adjusting plate makes the adjusting plate can adjust for support piece's vertical position and horizontal position to make the position of fixing a position magnetic part on the mounting panel can adjust, thereby adjust the stop position of final suspension, realize better location effect.

In one embodiment, the number of the suspensions is at least 4, the suspensions are arranged along the circumference of the turntable, and the positioning assemblies are at least two groups and are symmetrically arranged along the circumferential axis of the turntable. It can be understood that the more the number of the positioning components is, the better the positioning effect is, but the more complicated the equipment structure is, and according to the above arrangement, the better positioning effect can be realized.

In one embodiment, the positioning magnetic member and the positioning member are both magnets. It can be appreciated that the positioning magnetic member and the positioning member are made of magnetic materials capable of attracting each other, and the positioning magnetic member and the positioning member have the advantages of simplicity and stability according to the arrangement.

In one embodiment, the centrifugal assembly further comprises a mounting base fixed to the underside of the turntable, and the suspension is hinged to the mounting base.

In one embodiment, the positioning assembly further comprises a sensor fixed to the support member and a detection plate fixed to the turntable and movable with rotation of the turntable, the detection plate being positioned at the sensor detection position when the suspension is in the stopped state position, triggering the sensor to generate the positioning signal. Through the arrangement, the positioning model can be timely fed back to the automatic equipment control system.

In one embodiment, the number of the detecting pieces is consistent with the number of the suspensions, and the sensor is one; the supporting piece comprises a supporting plate vertically fixed on the bottom plate and a fixing plate horizontally fixed on the supporting plate, and the motor is fixed on the fixing plate; the centrifugal assembly further comprises a connecting plate, and the rotary disc is connected with the output end of the motor through the connecting plate. It can be appreciated that the number of sensors and detecting pieces can be flexibly set according to specific requirements, and one sensor is adopted to collect suspension stop position signals.

The invention also discloses a control method of the centrifugal device, which comprises the following steps:

and (3) a centrifugation procedure: the motor is controlled to start, the turntable rotates under the drive of the motor to drive the suspension to rotate and deviate from the stop state, and under the action of centrifugal force, the suspension is parallel to the turntable and is in the centrifugal state;

automatic positioning: and the motor is controlled to be closed, the turntable stops rotating, the suspension naturally sags under the action of gravity, the pipe cavity axis of the suspension is perpendicular to the plane of the turntable, and the positioning magnetic piece and the positioning piece generate suction force so that the suspension moves to the stop state position.

In one embodiment, a centrifugal device with a sensor and a detecting sheet is adopted, and after the automatic positioning step, a signal triggering step is further included, wherein the signal triggering step is as follows: and the suspension moves under the action of suction to drive the turntable to rotate, and when the suspension moves to the stop state position, the detection sheet triggers the sensor to generate a positioning signal.

Compared with the prior art, the invention has the following beneficial effects:

according to the centrifugal device, the suspension for placing the centrifugal tube is hinged with the turntable, centrifugal force and self gravity of the suspension are ingeniously utilized, the suspension naturally sags in a static state, and the suspension is attracted by magnetic force to fix the position, so that accurate positioning is realized; when in a centrifugal state, the motor is used for outputting power, so that the suspension is rotated and is parallel to the turntable under the action of centrifugal force, and the suspension is far away from the positioning magnetic piece, namely, the positioning attractive force is relieved, and the normal centrifugal flow without interference is realized. The centrifugal device utilizes simple low-cost element equipment, skillfully realizes the purpose of stopping automatic positioning of the centrifugal device on the premise of not increasing the volume of the centrifugal equipment, ensures that the centrifugal device can accurately position equipment stations, can be applied to full-automatic equipment, and improves the accuracy and efficiency of the equipment.

Drawings

FIG. 1 is an isometric view of a centrifuge apparatus in an example embodiment;

FIG. 2 is a schematic diagram of the axial structure of a centrifugal apparatus (stop state position) according to an embodiment;

FIG. 3 is a schematic view of the shaft side structure of the centrifugal apparatus (centrifugal status bit) in the embodiment;

FIG. 4 is a schematic top view of a centrifugal apparatus according to an embodiment;

fig. 5 is a schematic view showing a horizontal sectional structure of a centrifugal apparatus in the embodiment.

Wherein: 110. a bottom plate; 120. a turntable; 130. a motor; 141. a support plate; 142. a fixing plate; 150. a connecting plate; 160. a suspension; 161. a positioning piece; 162. a lumen; 170. a mounting base; 210. positioning the magnetic piece; 220. a mounting plate; 230. an adjustment plate; 231. a vertical adjustment hole; 240. a vertical fixing piece; 250. a sensor; 260. a detection sheet; 300. centrifuge tube.

Detailed Description

In order that the invention may be readily understood, a more complete description of the invention will be rendered by reference to the appended drawings. Preferred embodiments of the present invention are shown in the drawings. This invention may, however, be embodied in many different forms and should not be construed as limited to the embodiments set forth herein. Rather, these embodiments are provided so that this disclosure will be thorough and complete.

It will be understood that when an element is referred to as being "fixed to" another element, it can be directly on the other element or intervening elements may also be present. When an element is referred to as being "connected" to another element, it can be directly connected to the other element or intervening elements may also be present.

Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. The terminology used herein in the description of the invention is for the purpose of describing particular embodiments only and is not intended to be limiting of the invention. The term "and/or" as used herein includes any and all combinations of one or more of the associated listed items.

Examples

The invention discloses a centrifugal device, as shown in fig. 1-5, comprising: a centrifuge assembly and a positioning assembly.

The centrifugal assembly comprises a bottom plate 110, a rotary plate 120, a motor 130, a supporting member, a connecting plate 150 and a suspension 160, wherein the motor 130 and the supporting member are both fixed on the bottom plate 110, the rotary plate 120 is connected with an output end (output shaft) of the motor 130 through the connecting plate 150 and is rotatably fixed on the supporting member, namely, the motor 130 provides rotary centrifugal driving force for the rotary plate 120.

Specifically, the supporting member includes a supporting plate 141 vertically fixed to the base plate 110 and a fixing plate 142 horizontally fixed to the supporting plate 141, and the motor 130 is fixed to the fixing plate 142; the hanger 160 is provided with a positioning member 161 and a lumen 162 for placing a centrifuge tube. In this embodiment, the centrifugal assembly further includes a mounting base 170, where the mounting base 170 is fixed on the lower side of the turntable 120, the suspension 160 is hinged to the mounting base 170 and can rotate around the plane of the turntable 120 to enable the suspension 160 to have a centrifugal state position (fig. 2) and a stop state position (fig. 3), when the suspension 160 is in the centrifugal state position, the axis of the tube cavity 162 of the suspension 160 is parallel to the plane of the turntable 120, and when the suspension 160 is in the stop state position, the axis of the tube cavity 162 of the suspension 160 is perpendicular to the plane of the turntable 120.

The positioning assembly includes a positioning magnetic member 210 and a mounting plate 220, wherein the positioning magnetic member 210 is fixed on the supporting member, specifically, on the supporting plate 141, and when the suspension 160 is in the stop state, the positioning magnetic member 210 is opposite to and attracts the positioning member 161.

In this embodiment, the positioning member 161 is disposed at the bottom of the suspension 160, the positioning magnetic member 210 is fixed on the supporting member by a mounting plate 220, and the mounting plate 220 is disposed below the suspension 160. Specifically, the positioning assembly further includes an adjusting plate 230, a vertical fixing member 240 and a horizontal fixing member, the adjusting plate 230 is provided with a vertical installation bar and a horizontal installation bar, a bar-shaped vertical adjustment hole 231 is provided on the vertical installation bar, a bar-shaped horizontal adjustment hole is provided on the horizontal installation bar, the vertical fixing member 240 passes through the vertical adjustment hole 231 to fix the adjusting plate 230 on the supporting member, and the horizontal fixing member passes through the horizontal adjustment hole to fix the mounting plate 220 on the adjusting plate 230.

It will be appreciated that the relative positions of the positioning member 161 and the positioning magnetic member 210 can be designed according to the specific positions of other elements, and only the positioning magnetic member 210 needs to be fixed. The positioning member 161 is disposed at the bottom of the suspension 160, the positioning magnetic member 210 is mounted below the suspension 160 through the mounting plate 220, the suspension 160 naturally sags and the distance between the positions of the positioning member 161 is larger when the positioning member is parallel to the turntable 120, which is beneficial to the switching of the suspension 160 between different states.

For the positioning magnetic member 210 and the positioning member 161, in this embodiment, the positioning magnetic member 210 and the positioning member 161 are both magnets. It will be appreciated that the positioning magnetic member 210 and the positioning member 161 may be made of magnetic materials that can attract each other, and according to the above arrangement, there is an advantage of simplicity and reliability.

Because of certain difference of magnetic field force of the magnets, in order to ensure consistent stabilizing effect of installation of corresponding stations of different suspensions 160 on the turntable 120; the adjustable plate 230 is provided with a vertical adjustment hole 231 and a horizontal adjustment hole for adjusting the horizontal position and height of the positioning magnetic member 210, thereby ensuring the stability and consistency of the centrifugal device.

In addition, the design of the adjusting plate 230 enables the adjusting plate 230 to adjust the vertical position and the horizontal position of the supporting member, so that the position of the positioning magnetic member 210 fixed on the mounting plate 220 can be adjusted, and the stopping position of the final suspension 160 can be adjusted, thereby realizing a better positioning effect.

In this embodiment, the number of the suspensions 160 is 4 (a plurality of suspensions 160 may be provided according to experimental requirements and pairing requirements in centrifugal equipment, and used for accommodating a plurality of centrifugal tubes), the positioning assemblies are at least two groups and symmetrically arranged along the circumferential axis of the turntable 120. It can be understood that the more the number of the positioning components is, the better the positioning effect is, but the more complicated the equipment structure is, and according to the above arrangement, the better positioning effect can be realized.

In this embodiment, in order to implement automatic control of the automation device, the positioning assembly further includes a sensor 250 and four detecting pieces 260, where the sensor 250 is fixed on the support, the detecting pieces 260 are fixed on the turntable 120 and are respectively disposed at positions corresponding to the four suspensions 160, and the detecting pieces 260 can move along with rotation of the turntable 120, and when the suspensions 160 are in the stop state, the detecting pieces 260 are located at the detecting positions of the sensor 250, and trigger the sensor 250 to generate the positioning signal. Through the arrangement, the positioning model can be timely fed back to the automatic equipment control system.

The working flow and the control method of the centrifugal device are as follows:

1. centrifugation step

The motor 130 is controlled to start, the turntable 120 is driven by the motor 130 to rotate, the suspension 160 is driven to rotate and deviate from the stop state position, and the suspension 160 is parallel to the turntable under the action of centrifugal force and is in the centrifugal state position.

The method comprises the following steps:

1) In an automated process of the automated equipment, the robotic arm places the centrifuge tube 300 into the lumen 162 of the hanger bracket 160; because the positioning member 161 (magnet) with a positioning function is arranged at the bottom of the suspension 160, the positioning member 161 and the positioning magnetic member 210 interact with each other, and are subjected to attractive magnetic force, so that the positioning member is accurately positioned on a designated station, namely, a stop state is maintained, and the suspension 160 and the axis of the pipe cavity 162 thereof are maintained to be vertical to the horizontal plane.

2) After the centrifuge tube 300 is placed, the motor 130 is started, the motor 130 outputs, and the turntable 120 gradually starts to rotate.

3) In the process of driving the motor 130, the suspension 160 is driven by the turntable 120 to start to perform circular motion, and is released from the attraction of the positioning magnetic member 210 under the action of centrifugal force, so that the suspension is gradually converted into a state of being subjected to centrifugal force, and the motion state is horizontal, and then the sample is centrifuged under the high circular motion until the centrifugation is completed.

2. Automatic positioning

When the turntable 120 gradually stops rotating, the suspension 160 naturally sags under the action of gravity, the axis of the tube cavity 162 is perpendicular to the plane of the turntable 120, and the positioning magnetic member 210 and the positioning member 161 generate suction force through the N-S magnetic field, so that the suspension 160 moves to the stop state under the action of the magnet suction force, and the stop is fast and stable. The method comprises the following steps:

1) After the centrifugation is completed, the rotation speed of the motor 130 is gradually reduced until the motor is stopped in the logic control process, in the process, the suspension 160 is gradually restored to the vertical state, at this time, the suction force between the positioning magnetic member 210 and the positioning member 161 starts to act, the suspension 160 is attracted to be in the stop state, and the accurate positioning of the suspension 160 is completed under the logic control of the program.

3. Signal triggering

The suspension 160 moves to drive the turntable 120 to rotate, and when the suspension 160 moves to the stop state position, the detecting piece 260 triggers the sensor 250 to generate a positioning signal. The method comprises the following steps:

in the process of automatic positioning, the detecting piece 260 arranged at the bottom of the turntable 120 can pass through the groove of the sensor 250 in real time to complete the detection action, and is fed back to the automatic control system in real time.

The technical features of the above-described embodiments may be arbitrarily combined, and all possible combinations of the technical features in the above-described embodiments are not described for brevity of description, however, as long as there is no contradiction between the combinations of the technical features, they should be considered as the scope of the description.

The above examples illustrate only a few embodiments of the invention, which are described in detail and are not to be construed as limiting the scope of the invention. It should be noted that it will be apparent to those skilled in the art that several variations and modifications can be made without departing from the spirit of the invention, which are all within the scope of the invention. Accordingly, the scope of protection of the present invention is to be determined by the appended claims.

Claims

1. A centrifugal apparatus, comprising:

2. The centrifugal device according to claim 1, wherein the positioning member is provided at the bottom of the suspension, the positioning magnetic member is fixed to the supporting member by a mounting plate, and the mounting plate is provided below the suspension.

3. The centrifugal device of claim 1, wherein the positioning assembly further comprises an adjusting plate, a vertical fixing member and a horizontal fixing member, the adjusting plate is provided with a vertical mounting bar and a horizontal mounting bar, the vertical mounting bar is provided with a strip-shaped vertical adjusting hole, the horizontal mounting bar is provided with a strip-shaped horizontal adjusting hole, the vertical fixing member passes through the vertical adjusting hole to fix the adjusting plate on the supporting member, and the horizontal fixing member passes through the horizontal adjusting hole to fix the mounting plate on the adjusting plate.

4. The centrifugal apparatus according to claim 1, wherein the number of said suspensions is at least 4, and said positioning members are at least two, and are symmetrically arranged along the circumferential axis of said turntable.

5. The centrifuge of claim 1 wherein said positioning magnetic member and said positioning member are both magnets.

6. The centrifuge of claim 1 wherein said centrifuge assembly further comprises a mount secured to an underside of said turntable, said suspension being hinged to said mount.

7. The centrifuge of claim 1 wherein said positioning assembly further comprises a sensor secured to said support and a sensing tab secured to said turntable and movable with rotation of said turntable, said sensing tab being positioned at said sensor sensing location to trigger the sensor to generate a positioning signal when said suspension is in said off state.

8. The centrifugal device according to claim 7, wherein the number of the detecting pieces is identical to the number of the suspensions, and the sensor is one;

the supporting piece comprises a supporting plate vertically fixed on the bottom plate and a fixing plate horizontally fixed on the supporting plate, and the motor is fixed on the fixing plate;

the centrifugal assembly further comprises a connecting plate, and the rotary disc is connected with the output end of the motor through the connecting plate.

9. A control method of a centrifugal device according to any one of claims 1-8, comprising the steps of:

automatic positioning: the turntable stops rotating, the suspension naturally sags under the action of gravity, the axis of the pipe cavity of the suspension is perpendicular to the plane of the turntable, and the positioning magnetic piece and the positioning piece generate suction force to enable the suspension to move to the stop state.

10. The control method according to claim 9, characterized in that the centrifugal device according to claim 7 or 8 is employed, and that after the automatic positioning step, a signal triggering step is further included, the signal triggering step being: and the suspension moves under the action of suction to drive the turntable to rotate, and when the suspension moves to the stop state position, the detection sheet triggers the sensor to generate a positioning signal.