CN115957150A

CN115957150A - Anti-wrinkle and tightening composition containing adenosine and application thereof

Info

Publication number: CN115957150A
Application number: CN202211305646.1A
Authority: CN
Inventors: 初海隆
Original assignee: Austin Biotechnology Co ltd
Current assignee: Austin Biotechnology Co ltd
Priority date: 2022-10-24
Filing date: 2022-10-24
Publication date: 2023-04-14

Abstract

The invention discloses an anti-wrinkle firming composition containing adenosine and application thereof, wherein the adenosine can increase the production of dermal fibroblast protein, reduce skin relaxation and improve color tone, and the anti-wrinkle effect can be enhanced by compounding thiotaurine; the glucosaminoglycans have a certain inhibiting effect on the activity of collagenase, so that the skin tightening effect is achieved, the instant effect is better when the glucosaminoglycans are used alone, but the anti-wrinkle effect is better when the glucosaminoglycans are compounded with the thiotaurine and the adenosine. When the three components are combined to form the anti-wrinkle and firming composition, the anti-wrinkle and firming composition has a very remarkable anti-wrinkle and firming effect on skin, is mild and non-irritant, can be used as an active ingredient for resisting wrinkle and firming, and is applied to cosmetics.

Description

Anti-wrinkle and tightening composition containing adenosine and application thereof

Technical Field

The invention relates to the field of cosmetics, in particular to an anti-wrinkle firming composition containing adenosine, thiotaurine and glucosamino and application thereof in anti-wrinkle firming.

Background

The formation of wrinkles in the skin is often manifested by a decrease in skin elasticity, an increase in skin roughness, a decrease in moisturizing intensity, and the like. The anti-wrinkle effect substances in the market mainly comprise A alcohol, peptides and the like, have certain irritation and are low in cost performance. The anti-wrinkle firming composition has obvious effects of firming skin, fading wrinkles and resisting oxidation. Among them, adenosine, an endogenous nucleoside distributed throughout human cells, is composed of ribose (ribofuranose) and a part of adenine, plays an important role in biochemistry, and can increase the production of dermal fibroblast protein, reduce skin relaxation and improve color tone. The thiotaurine has a certain oxidation resistance, and the glucosaminoglycans have a certain inhibition effect on the activities of collagenase and CO adenosine-2, so that the effects of resisting wrinkles and reducing wrinkles are achieved.

Disclosure of Invention

Aiming at the defects of the prior art, the anti-wrinkle firming composition has obvious effects of firming skin, smoothing wrinkles and resisting oxidation. Among them, adenosine, an endogenous nucleoside distributed throughout human cells, is composed of ribose (ribofuranose) and a part of adenine, plays an important role in biochemistry, and can increase the production of dermal fibroblast protein, reduce skin relaxation and improve color tone. The thiotaurine has a certain oxidation resistance, the glucosaminoglycan has a certain inhibition effect on activities of collagenase and CO adenosine-2, so that the anti-wrinkle effect is achieved, and the anti-wrinkle effect is remarkable when the anti-wrinkle firming composition aqueous solution prepared by combining the thiotaurine, the glucosaminoglycan and the glucosaminoglycan is used in cosmetics.

Specifically, the invention provides an anti-wrinkle firming composition containing adenosine, thiotaurine and glucosamino and application thereof in anti-wrinkle firming.

Preferably, the adenosine is from a commercial raw material producer and can be used as long as the structural and functional purity is substantially consistent. It can promote the generation of collagen protein and reduce skin wrinkles.

The invention also provides a preparation method of the anti-wrinkle firming composition containing adenosine, thiotaurine and glucosamino, which comprises the following steps:

step S1, providing adenosine, thiotaurine and glucosaminodextran;

and S2, mixing the adenosine, the thiotaurine and the glucosaminoglucan to obtain the anti-wrinkle and anti-tightening composition.

Preferably, the anti-wrinkle firming cosmetic comprises 1-15% of a firming, anti-wrinkle firming composition.

Preferably, the tightening anti-wrinkle cosmetic comprises 2-12% of a tightening anti-wrinkle tightening composition.

Preferably, the anti-wrinkle firming cosmetic is an anti-wrinkle firming mask and an anti-wrinkle firming cream.

The invention also provides application of the anti-wrinkle firming composition containing adenosine, thiotaurine and glucosamino in preparing cosmetics for resisting wrinkles and firming.

Preferably, the anti-wrinkle and tightening composition is mild and non-irritant, can be used as an anti-wrinkle and tightening active component, and can be applied to various cosmetics.

Drawings

In order to more clearly illustrate the embodiments or technical solutions of the present invention, the drawings used in the embodiments or technical solutions of the prior art will be briefly described below, it is obvious that the drawings in the following description are only some embodiments of the present invention, and for those skilled in the art, other drawings can be obtained according to the structures shown in the drawings without creative efforts.

Fig. 1 is a flow chart illustrating a method for preparing an anti-wrinkle tightening composition according to an embodiment of the present invention.

Fig. 2 is a test result of anti-wrinkle after 1 month for a tester who applies the anti-wrinkle cream of example six to the left eye according to the present invention.

Fig. 3 is a test result of anti-wrinkle after 1 month for a tester who applies the anti-wrinkle cream of example seven to the right eye of the present invention.

Fig. 4 is a test result of anti-wrinkle after 1 month for a tester applying the anti-wrinkle cream of example seven to the left eye of the present invention.

Fig. 5 is a test result of anti-wrinkle after 1 month for a tester who applies the anti-wrinkle cream of example eight to the left eye according to the present invention.

Fig. 6 is a test result of anti-wrinkle after ten months for a tester applying the anti-wrinkle cream of example nine to the left eye according to the present invention.

Fig. 7 is a wrinkle resistance test result of a tester who applied the wrinkle resistant cream of example nine to the left eye after 1 month according to the present invention.

Fig. 8 is a wrinkle resistance test result after 1 month for testers of the wrinkle resistant milk of example nine of the left eye application of the present invention.

Fig. 9 is a wrinkle resistance test result of a tester applying the wrinkle resistant cream of example ten to the left eye of the present invention after 1 month.

The implementation, functional features and advantages of the present invention will be further described with reference to the accompanying drawings.

Detailed Description

The technical solutions in the embodiments of the present invention will be described clearly and completely below, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

In addition, the descriptions related to "first", "second", etc. in the present invention are for descriptive purposes only and are not to be construed as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defined as "first" or "second" may explicitly or implicitly include at least one such feature. In addition, technical solutions between the embodiments may be combined with each other, but must be based on the realization of the technical solutions by a person skilled in the art, and when the technical solutions are contradictory to each other or cannot be realized, such a combination should not be considered to exist, and is not within the protection scope of the present invention.

Referring to fig. 1, the present invention provides a method for preparing an anti-wrinkle and anti-firming composition, comprising the following steps:

step S1, providing adenosine, thiotaurine, glucosaminodextran and deionized water;

and S2, mixing the adenosine, the thiotaurine, the glucosaminoglucan and the deionized water to obtain the anti-wrinkle and anti-tightening composition.

In some embodiments, in the anti-wrinkle and anti-firming composition, the adenosine is 0.0001-30% by mass, the thiotaurine is 0.0001-20% by mass, the glycosaminoglycans is 0.0001-30% by mass, and the deionized water is 20-99.9997% by mass.

In some embodiments, in the anti-wrinkle and anti-compact composition, the adenosine is 0.1-20% by mass, the thiotaurine is 0.1-15% by mass, the glycosaminoglycans is 0.1-20% by mass, and the deionized water is 55-99.7% by mass.

The adenosine has effects of tightening skin, increasing skin elasticity, removing wrinkle, and resisting oxidation.

The thiotaurine is an antioxidant and can protect cells in a human body.

The glucosaminoglycans have a certain anti-wrinkle effect.

Adenosine is an endogenous nucleoside that is distributed throughout human cells. Adenosine is the basic dorsal bone of the human phosphate energy system (e.g., ADP and ATP). Many cellular respiratory responses, including mitochondrial energy, depend on it, and it is not only an energy carrier, but also a signaling molecule that can increase production of dermal fibroblast proteins.

The thiotaurine has the effects of safety, no toxicity, oxidation resistance and the like.

In the technical scheme of the invention, the preparation method of the anti-wrinkle and anti-firming composition comprises the following steps: providing adenosine, thiotaurine, and glycosaminoglycans; and mixing the adenosine, the thiotaurine and the glucosaminoglucan to obtain the anti-wrinkle and firming composition. In the anti-wrinkle firming composition, adenosine and thiotaurine have extremely strong functions of firming skin, reducing fine wrinkles and resisting oxidation; the adenosine, the thiotaurine and the glucosaminoglycan are used in combination, so that the anti-wrinkle firming composition can better realize the effects of firming skin, reducing fine wrinkles and resisting oxidation. Moreover, the anti-wrinkle firming composition is mild and non-irritant, can be used as an anti-wrinkle active component, and can be applied to various cosmetics.

The invention also provides an anti-wrinkle firming composition which contains adenosine, thiotaurine and glucosaminoglycan.

In some embodiments, in the anti-wrinkle and anti-firming composition, the adenosine is 0.1 to 20% by mass, the thiotaurine is 0.1 to 15% by mass, the glycosaminoglycans is 0.1 to 20% by mass, and the deionized water is 55 to 99.7% by mass.

The adenosine has effects of tightening skin, increasing skin elasticity, and eliminating wrinkle.

The thiotaurine is a natural antioxidant and can protect cells in a human body.

The glycosaminoglycans have excellent anti-wrinkle effects.

The thiotaurine has the effects of natural safety, no toxicity, oxidation resistance and the like.

In the technical scheme of the invention, the anti-wrinkle firming composition contains adenosine, thiotaurine and glucosaminoglycan. The adenosine and the thiotaurine have extremely strong functions of tightening skin, reducing fine wrinkles and resisting oxidation; glucosaminoglycans have excellent anti-wrinkle effects. The adenosine, the thiotaurine and the glucosaminoglycan are used in combination, so that the anti-wrinkle firming composition can better realize the effects of firming skin, reducing fine wrinkles and resisting oxidation. Moreover, the anti-wrinkle firming composition is mild and non-irritant, can be used as an anti-wrinkle active component, and can be applied to various cosmetics.

The invention also provides a cosmetic which comprises at least one of a humectant, a thickening agent, an emulsifier, a preservative, essence and a neutralizer, and also comprises the anti-wrinkle firming composition and water, wherein the anti-wrinkle firming composition accounts for 0.1-10% by mass in the cosmetic.

In some embodiments, the anti-wrinkle and tightening composition is 1-15% by mass.

Since the cosmetic adopts all technical solutions of all the embodiments, the cosmetic at least has all the beneficial effects brought by the technical solutions of the embodiments, and details are not repeated herein.

Preferably, the anti-wrinkle cosmetic is an anti-wrinkle mask, an anti-wrinkle essence, an anti-wrinkle cream or an anti-wrinkle cream.

In some embodiments, the humectant is at least one of glycerin, propylene glycol, malonic acid, ammonium acryloyldimethyltaurate/VP copolymer, and butylene glycol.

In some embodiments, the thickener is at least one of carbomer, hydroxyethyl cellulose, acrylic/C10-30 alkanol acrylate crosspolymer, and xanthan gum.

In some embodiments, the emulsifier is at least one of steareth-2, polyglyceryl fatty acid ester, isononyl isononanoate, C14-22 alcohol/C12-20 alkyl glucoside, cetearyl alcohol, cetearyl glucoside, shea butter, dimethicone, and polysorbate-60.

In some embodiments, the preservative is at least one of p-hydroxyacetophenone, 1, 2-hexanediol, methylparaben, propylparaben, ethylhexylglycerin, and phenoxyethanol.

In some embodiments, the neutralizing agent is at least one of disodium edetate, arginine, and triethanolamine.

In some embodiments, the fragrance is lanolin and/or hydrogenated castor oil.

In some embodiments, the humectant is present in the cosmetic in an amount of 2 to 10% by weight.

In some embodiments, the content of the thickener in the cosmetic is 0.1 to 0.5% by mass.

In some embodiments, the content of the emulsifier in the cosmetic is 2 to 12% by mass.

In some embodiments, the preservative is contained in the cosmetic in an amount of 0.2 to 1% by mass.

In some embodiments, the content of the neutralizer in the cosmetic is 0.01 to 0.1% by mass.

In some embodiments, the essence is contained in the cosmetic in an amount of 0.005-0.5% by mass.

In some embodiments, the cosmetic further comprises water/butylene glycol/purslane extract in an amount of 0.5-1% by weight, so as to prevent skin from drying and aging, remove free radicals, and increase skin comfort.

It can be understood that the method for preparing the cosmetics is a preparation method of the cosmetics commonly used in the field, and the details are not repeated herein.

Example one

And (3) preparing thiotaurine and deionized water into an anti-wrinkle firming composition aqueous solution according to a ratio of 1.

Example two

The anti-wrinkle firming composition is an aqueous solution prepared from adenosine and deionized water in a ratio of 1.

EXAMPLE III

Thiotaurine, adenosine and deionized water were formulated into an aqueous anti-wrinkle firming composition solution at 1.

Example four

The glycosaminoglycans and deionized water were formulated into an aqueous anti-wrinkle firming composition solution at 1

EXAMPLE five

Thiotaurine, adenosine and glucosaminoglycan and deionized water were formulated into an anti-wrinkle firming composition in water at a ratio of 1

EXAMPLE six

Providing a phase A, a phase B, a phase C, a phase D, and a phase E, wherein the phase A comprises water, an ammonium acryloyldimethyl taurate/VP copolymer, and butylene glycol; the phase B comprises C14-22 alcohol/C12-20 alkyl glucoside, cetearyl alcohol/cetearyl glucoside, shea butter, isononyl isononanoate, and polydimethylsiloxane; the phase C is the anti-wrinkle and anti-tightening composition of the first embodiment; the phase D comprises 1, 2-hexanediol and phenoxyethanol/ethylhexyl glycerin; the phase E comprises water/butylene glycol/purslane extract;

adding the phase A into an emulsifying pot, homogenizing for 3min, heating to 85 ℃, and stirring until the phase A is completely dissolved to obtain a phase A solution;

adding the phase B into an oil phase pot, stirring and heating to 85 ℃, and stirring until the phase B is completely dissolved to obtain a phase B solution;

adding the phase A solution into the phase B solution, stirring for 5min, homogenizing for 3min, keeping the temperature for 15min, adding the phase C, and stirring to obtain a mixed solution;

and adding the phase D and the phase E into the mixed solution, uniformly stirring, cooling to below 45 ℃, filtering by using a 150-mesh filter screen, and discharging to obtain the anti-wrinkle milk of the first embodiment. The anti-wrinkle milk in the first embodiment comprises, by mass, 83.55% of water, 0.4% of ammonium acryloyldimethyltaurate/VP copolymer, 2% of butylene glycol, 2% of C14-22 alcohol/C12-20 alkyl glucoside, 0.8% of cetearyl alcohol/cetearyl glucoside, 5% of shea butter, 3% of isononyl isononanoate, 1% of polydimethylsiloxane, 5% of an anti-wrinkle firming composition (the anti-wrinkle milk contains 0.5% of thiotaurine by mass), 0.5% of 1, 2-hexanediol, 0.25% of phenoxyethanol/ethylhexyl glycerin by mass, and 1% of water/butylene glycol/purslane extract.

EXAMPLE seven

Providing a phase A, a phase B, a phase C, a phase D, and a phase E, wherein the phase A comprises water, an ammonium acryloyldimethyl taurate/VP copolymer, and butanediol; the phase B comprises C14-22 alcohol/C12-20 alkyl glucoside, cetearyl alcohol/cetearyl glucoside, shea butter, isononyl isononanoate, and polydimethylsiloxane; the phase C is the anti-wrinkle and anti-firming composition of example two; the phase D comprises 1, 2-hexanediol and phenoxyethanol/ethylhexyl glycerin; the phase E comprises water/butylene glycol/purslane extract;

and adding the phase D and the phase E into the mixed solution, uniformly stirring, cooling to below 45 ℃, filtering by using a 150-mesh filter sieve, and discharging to obtain the anti-wrinkle milk of the second embodiment. The anti-wrinkle milk of the second embodiment comprises, by mass, 83.55% of water, 0.4% of ammonium acryloyldimethyltaurate/VP copolymer, 2% of butylene glycol, 2% of C14-22 alcohol/C12-20 alkyl glucoside, 0.8% of cetearyl alcohol/cetearyl glucoside, 5% of shea butter, 3% of isononyl isononanoate, 1% of polydimethylsiloxane, 5% of an anti-wrinkle firming composition (0.5% of adenosine in the anti-wrinkle milk), 0.5% of 1, 2-hexanediol, 0.25% of phenoxyethanol/ethylhexyl glycerol, and 1% of water/butylene glycol/purslane extract.

Example eight

Providing a phase A, a phase B, a phase C, a phase D, and a phase E, wherein the phase A comprises water, an ammonium acryloyldimethyl taurate/VP copolymer, and butylene glycol; the phase B comprises C14-22 alcohol/C12-20 alkyl glucoside, cetearyl alcohol/cetearyl glucoside, shea butter, isononyl isononanoate, and polydimethylsiloxane; the phase C is the anti-wrinkle and anti-firming composition of example three; the phase D comprises 1, 2-hexanediol and phenoxyethanol/ethylhexyl glycerin; the phase E comprises water/butylene glycol/purslane extract;

and adding the D phase and the E phase into the mixed solution, uniformly stirring, cooling to below 45 ℃, filtering by using a 150-mesh filter screen, and discharging to obtain the anti-wrinkle milk of the third embodiment. The anti-wrinkle milk of the third embodiment comprises, by mass, 83.05% of water, 0.4% of ammonium acryloyldimethyltaurate/VP copolymer, 2% of butylene glycol, 2% of C14-22 alcohol/C12-20 alkyl glucoside, 0.8% of cetearyl alcohol/cetearyl glucoside, 5% of shea butter, 3% of isononyl isononanoate, 1% of polydimethylsiloxane, 5% of an anti-wrinkle firming composition (in the anti-wrinkle milk, the adenosine is 0.5% by mass, the thiotaurine is 0.5% by mass), 0.5% of 1, 2-hexanediol, 0.25% of ethanol/ethylhexylglycerin, and 1% of water/butylene glycol/purslane extract.

Example nine

Providing a phase A, a phase B, a phase C, a phase D, and a phase E, wherein the phase A comprises water, an ammonium acryloyldimethyl taurate/VP copolymer, and butanediol; the phase B comprises C14-22 alcohol/C12-20 alkyl glucoside, cetearyl alcohol/cetearyl glucoside, shea butter, isononyl isononanoate, and polydimethylsiloxane; the phase C is the anti-wrinkle and anti-tightening composition of the example search; the phase D comprises 1, 2-hexanediol and phenoxyethanol/ethylhexyl glycerin; the phase E comprises water/butylene glycol/purslane extract;

and adding the phase D and the phase E into the mixed solution, uniformly stirring, cooling to below 45 ℃, filtering by using a 150-mesh filter screen, and discharging to obtain the anti-wrinkle milk of the fourth embodiment. The anti-wrinkle milk of the fourth embodiment contains, by mass, 83.55% of water, 0.4% of ammonium acryloyldimethyltaurate/VP copolymer, 2% of butylene glycol, 2% of C14-22 alcohol/C12-20 alkyl glucoside, 0.8% of cetearyl alcohol/cetearyl glucoside, 5% of shea butter, 3% of isononyl isononanoate, 1% of polydimethylsiloxane, 5% of an anti-wrinkle firming composition (in the anti-wrinkle milk, the content of glucosaminoglycan is 0.5%, 0.5% of 1, 2-hexanediol, 0.25% of phenoxyethanol/ethylhexyl glycerin, and 1% of water/butylene glycol/purslane extract.

Example ten

Providing a phase A, a phase B, a phase C, a phase D, and a phase E, wherein the phase A comprises water, an ammonium acryloyldimethyl taurate/VP copolymer, and butanediol; the phase B comprises C14-22 alcohol/C12-20 alkyl glucoside, cetearyl alcohol/cetearyl glucoside, shea butter, isononyl isononanoate, and polydimethylsiloxane; the phase C is the anti-wrinkle and anti-firmness composition of example five; the phase D comprises 1, 2-hexanediol and phenoxyethanol/ethylhexyl glycerin; the phase E comprises water/butylene glycol/purslane extract;

and adding the phase D and the phase E into the mixed solution, uniformly stirring, cooling to below 45 ℃, filtering by using a 150-mesh filter sieve, and discharging to obtain the anti-wrinkle milk prepared in the fifth embodiment. The anti-wrinkle milk of the fifth embodiment comprises, by mass, 82.55% of water, 0.4% of ammonium acryloyldimethyltaurate/VP copolymer, 2% of butylene glycol, 2% of C14-22 alcohol/C12-20 alkyl glucoside, 0.8% of cetearyl alcohol/cetearyl glucoside, 5% of shea butter, 3% of isononyl isononanoate, 1% of polydimethylsiloxane, 5% of an anti-wrinkle firming composition (in the anti-wrinkle milk, the adenosine is 0.5% by mass, the thiotaurine is 0.5% by mass, the glycosaminoglycans is 0.5% by mass), 0.5% of 1, 2-hexanediol, 0.25% of phenoxyethanol/ethylhexylglycerin, and 1% of water/butylene glycol extract.

20 cleaned face test subjects were randomly selected, and after resting for 15 minutes at a fixed position, eye wrinkle values were measured with a skin tester and recorded. The anti-wrinkle milks of example six were applied to the left eye and the anti-wrinkle milks of example seven were applied to the right eye of each test person for one month. After cleaning the face and eyes, the wrinkle values of the eyes were measured with a skin tester and the condition was recorded.

Referring to fig. 2-3, the right eye wrinkle reduction value of trial example seven is significantly greater than the left eye wrinkle reduction value of trial example six. This shows that the monotherapy using thiotaurine has no obvious anti-wrinkle effect, and the monotherapy using adenosine has certain anti-wrinkle effect.

20 cleaned face testers were randomly selected, and after resting for 15 minutes in a fixed position, eye wrinkle values were measured with a skin tester and recorded. The anti-wrinkle cream of example seven was applied to the left eye and the anti-wrinkle cream of example eight was applied to the right eye of each test person for one month. After cleaning the face and eyes, the wrinkle values of the eyes were measured with a skin tester and the condition was recorded.

Referring to fig. 4-5, the right eye wrinkle reduction value of trial example eight is significantly greater than the left eye wrinkle reduction value of trial example seven. The result shows that the thiotaurine is compounded with the adenosine, and the anti-wrinkle effect of the adenosine is more obvious due to the thiotaurine.

20 cleaned face test subjects were randomly selected, and after resting for 15 minutes at a fixed position, eye wrinkle values were measured with a skin tester and recorded. The immediate effect was photographed ten minutes after each test person's left eye was applied with the anti-wrinkle cream of example nine, and the right eye was applied with the anti-wrinkle cream of example nine for a month. After cleaning the face and eyes, the wrinkle values of the eyes were measured with a skin tester and the condition was recorded.

Referring to fig. 6 to 7, the right-eye wrinkle reduction value of trial example eight is not much different from the left-eye wrinkle reduction value of trial example seven. This indicates that the anti-wrinkle effect of glycosaminoglycans is immediate and does not add up over a long period of use.

20 cleaned face testers were randomly selected, and after resting for 15 minutes in a fixed position, eye wrinkle values were measured with a skin tester and recorded. The anti-wrinkle cream of example nine was applied to the left eye and the anti-wrinkle cream of example ten was applied to the right eye of each test person for one month. After cleaning the face and eyes, the wrinkle values of the eyes were measured with a skin tester and the condition was recorded.

Referring to fig. 8-9, the right eye wrinkle reduction value of trial example ten is significantly greater than the left eye wrinkle reduction value of trial example nine. This indicates that the anti-wrinkle effect is significantly increased when thiotaurine, adenosine and glycosaminoglycans are used in combination.

Claims

1. A preparation method of an anti-wrinkle firming composition comprises the following steps:

providing adenosine, thiotaurine and glycosaminoglycans; and mixing the adenosine, the thiotaurine and the glucosaminoglycan to obtain the anti-wrinkle firming composition.

2. The anti-wrinkle firming composition is characterized in that thiotaurine has a general anti-wrinkle effect, but can enhance the capability of adenosine in promoting fibroblast protein production by compounding with adenosine, so that the anti-wrinkle effect is enhanced.

3. The anti-wrinkle firming composition is characterized in that glucosaminoglycans have immediate anti-wrinkle ability, and the anti-wrinkle effect of the compound adenosine and thiotaurine has additive effect when the compound adenosine and thiotaurine are used.

4. An anti-wrinkle firming composition characterized by an enhanced anti-wrinkle effect in combination with adenosine, thiotaurine and glycosaminoglycans.

5. The method for preparing the anti-wrinkle and anti-firmness composition according to claim 1, wherein the anti-wrinkle and anti-firmness composition comprises 0.0001 to 30 percent by mass of adenosine, 0.0001 to 20 percent by mass of thiotaurine, 0.0001 to 30 percent by mass of glycosaminoglycans and 20 to 99.9997 percent by mass of deionized water.

6. The method for preparing the anti-wrinkle and anti-firmness composition according to claim 1, wherein in the anti-wrinkle and anti-firmness composition, the adenosine is 0.1-20% by mass, the thiotaurine is 0.1-15% by mass, the glycosaminoglycans is 0.1-20% by mass, and the deionized water is 55-99.7% by mass.

7. A cosmetic comprising at least one of a moisturizing agent, a thickening agent, an emulsifying agent, a preservative, an essence and a neutralizing agent, wherein the cosmetic further comprises the anti-wrinkle and tightening composition as claimed in any one of claims 2 to 3 and water, and the anti-wrinkle and tightening composition is contained in the cosmetic in an amount of 0.1 to 20% by mass.

8. The cosmetic according to claim 7, wherein the anti-wrinkle and anti-firmness composition is contained in an amount of 1 to 15% by mass.