CN115869233A - Whitening and anti-wrinkle essence and preparation method thereof - Google Patents
Whitening and anti-wrinkle essence and preparation method thereof Download PDFInfo
- Publication number
- CN115869233A CN115869233A CN202310027116.3A CN202310027116A CN115869233A CN 115869233 A CN115869233 A CN 115869233A CN 202310027116 A CN202310027116 A CN 202310027116A CN 115869233 A CN115869233 A CN 115869233A
- Authority
- CN
- China
- Prior art keywords
- extract
- whitening
- parts
- essence
- wrinkle
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 230000002087 whitening effect Effects 0.000 title claims abstract description 56
- 230000001153 anti-wrinkle effect Effects 0.000 title claims abstract description 47
- 238000002360 preparation method Methods 0.000 title claims abstract description 24
- 239000000284 extract Substances 0.000 claims abstract description 83
- 239000000203 mixture Substances 0.000 claims abstract description 72
- 229920002385 Sodium hyaluronate Polymers 0.000 claims abstract description 43
- 229940010747 sodium hyaluronate Drugs 0.000 claims abstract description 43
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 claims abstract description 43
- 240000005125 Myrtus communis Species 0.000 claims abstract description 25
- 235000013418 Myrtus communis Nutrition 0.000 claims abstract description 25
- 229940107117 verbena extract Drugs 0.000 claims abstract description 16
- 239000002994 raw material Substances 0.000 claims abstract description 15
- 241000244355 Ligusticum Species 0.000 claims abstract description 14
- 241000951473 Schizonepeta Species 0.000 claims abstract description 12
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 37
- 239000012071 phase Substances 0.000 claims description 31
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 29
- 238000003756 stirring Methods 0.000 claims description 23
- 239000003755 preservative agent Substances 0.000 claims description 16
- 230000002335 preservative effect Effects 0.000 claims description 16
- 238000001816 cooling Methods 0.000 claims description 15
- 235000011187 glycerol Nutrition 0.000 claims description 13
- 125000003118 aryl group Chemical group 0.000 claims description 12
- -1 alkyl glucoside Chemical class 0.000 claims description 9
- QCDWFXQBSFUVSP-UHFFFAOYSA-N 2-phenoxyethanol Chemical compound OCCOC1=CC=CC=C1 QCDWFXQBSFUVSP-UHFFFAOYSA-N 0.000 claims description 8
- 229920001577 copolymer Polymers 0.000 claims description 8
- 229960005323 phenoxyethanol Drugs 0.000 claims description 8
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 claims description 6
- WVDDGKGOMKODPV-UHFFFAOYSA-N Benzyl alcohol Chemical compound OCC1=CC=CC=C1 WVDDGKGOMKODPV-UHFFFAOYSA-N 0.000 claims description 6
- GPLRAVKSCUXZTP-UHFFFAOYSA-N diglycerol Chemical compound OCC(O)COCC(O)CO GPLRAVKSCUXZTP-UHFFFAOYSA-N 0.000 claims description 6
- 239000004205 dimethyl polysiloxane Substances 0.000 claims description 6
- 239000000787 lecithin Substances 0.000 claims description 6
- 235000010445 lecithin Nutrition 0.000 claims description 6
- 229940067606 lecithin Drugs 0.000 claims description 6
- 238000000034 method Methods 0.000 claims description 6
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 claims description 6
- 239000002562 thickening agent Substances 0.000 claims description 6
- 229920001285 xanthan gum Polymers 0.000 claims description 6
- 239000000230 xanthan gum Substances 0.000 claims description 6
- 229940082509 xanthan gum Drugs 0.000 claims description 6
- 235000010493 xanthan gum Nutrition 0.000 claims description 6
- ANZUDYZHSVGBRF-UHFFFAOYSA-N 3-ethylnonane-1,2,3-triol Chemical compound CCCCCCC(O)(CC)C(O)CO ANZUDYZHSVGBRF-UHFFFAOYSA-N 0.000 claims description 5
- 239000003921 oil Substances 0.000 claims description 5
- 240000007817 Olea europaea Species 0.000 claims description 4
- BQMNFPBUAQPINY-UHFFFAOYSA-N azane;2-methyl-2-(prop-2-enoylamino)propane-1-sulfonic acid Chemical compound [NH4+].[O-]S(=O)(=O)CC(C)(C)NC(=O)C=C BQMNFPBUAQPINY-UHFFFAOYSA-N 0.000 claims description 4
- 239000003995 emulsifying agent Substances 0.000 claims description 4
- 229930182478 glucoside Natural products 0.000 claims description 4
- 235000019198 oils Nutrition 0.000 claims description 4
- 229940049964 oleate Drugs 0.000 claims description 4
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 claims description 4
- 210000002966 serum Anatomy 0.000 claims description 4
- PRAKJMSDJKAYCZ-UHFFFAOYSA-N squalane Chemical compound CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 claims description 4
- NCZPCONIKBICGS-UHFFFAOYSA-N 3-(2-ethylhexoxy)propane-1,2-diol Chemical compound CCCCC(CC)COCC(O)CO NCZPCONIKBICGS-UHFFFAOYSA-N 0.000 claims description 3
- 229940105990 diglycerin Drugs 0.000 claims description 3
- 229940100524 ethylhexylglycerin Drugs 0.000 claims description 3
- JNYAEWCLZODPBN-JGWLITMVSA-N (2r,3r,4s)-2-[(1r)-1,2-dihydroxyethyl]oxolane-3,4-diol Chemical compound OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O JNYAEWCLZODPBN-JGWLITMVSA-N 0.000 claims description 2
- CHHHXKFHOYLYRE-UHFFFAOYSA-M 2,4-Hexadienoic acid, potassium salt (1:1), (2E,4E)- Chemical compound [K+].CC=CC=CC([O-])=O CHHHXKFHOYLYRE-UHFFFAOYSA-M 0.000 claims description 2
- RMTFNDVZYPHUEF-XZBKPIIZSA-N 3-O-methyl-D-glucose Chemical compound O=C[C@H](O)[C@@H](OC)[C@H](O)[C@H](O)CO RMTFNDVZYPHUEF-XZBKPIIZSA-N 0.000 claims description 2
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims description 2
- 241000130781 Arnebia Species 0.000 claims description 2
- 229920001202 Inulin Polymers 0.000 claims description 2
- 235000018330 Macadamia integrifolia Nutrition 0.000 claims description 2
- 240000000912 Macadamia tetraphylla Species 0.000 claims description 2
- 235000003800 Macadamia tetraphylla Nutrition 0.000 claims description 2
- 229920002125 Sokalan® Polymers 0.000 claims description 2
- 241001135917 Vitellaria paradoxa Species 0.000 claims description 2
- 235000018936 Vitellaria paradoxa Nutrition 0.000 claims description 2
- 239000008346 aqueous phase Substances 0.000 claims description 2
- 235000021302 avocado oil Nutrition 0.000 claims description 2
- 239000008163 avocado oil Substances 0.000 claims description 2
- 235000019445 benzyl alcohol Nutrition 0.000 claims description 2
- 229960001631 carbomer Drugs 0.000 claims description 2
- 239000003240 coconut oil Substances 0.000 claims description 2
- 235000019864 coconut oil Nutrition 0.000 claims description 2
- KPUWHANPEXNPJT-UHFFFAOYSA-N disiloxane Chemical class [SiH3]O[SiH3] KPUWHANPEXNPJT-UHFFFAOYSA-N 0.000 claims description 2
- CNRDTAOOANTPCG-UHFFFAOYSA-N dodecyl carbamate Chemical compound CCCCCCCCCCCCOC(N)=O CNRDTAOOANTPCG-UHFFFAOYSA-N 0.000 claims description 2
- 239000003974 emollient agent Substances 0.000 claims description 2
- 150000008131 glucosides Chemical class 0.000 claims description 2
- XJNUECKWDBNFJV-UHFFFAOYSA-N hexadecyl 2-ethylhexanoate Chemical compound CCCCCCCCCCCCCCCCOC(=O)C(CC)CCCC XJNUECKWDBNFJV-UHFFFAOYSA-N 0.000 claims description 2
- 229940029339 inulin Drugs 0.000 claims description 2
- JYJIGFIDKWBXDU-MNNPPOADSA-N inulin Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)OC[C@]1(OC[C@]2(OC[C@]3(OC[C@]4(OC[C@]5(OC[C@]6(OC[C@]7(OC[C@]8(OC[C@]9(OC[C@]%10(OC[C@]%11(OC[C@]%12(OC[C@]%13(OC[C@]%14(OC[C@]%15(OC[C@]%16(OC[C@]%17(OC[C@]%18(OC[C@]%19(OC[C@]%20(OC[C@]%21(OC[C@]%22(OC[C@]%23(OC[C@]%24(OC[C@]%25(OC[C@]%26(OC[C@]%27(OC[C@]%28(OC[C@]%29(OC[C@]%30(OC[C@]%31(OC[C@]%32(OC[C@]%33(OC[C@]%34(OC[C@]%35(OC[C@]%36(O[C@@H]%37[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O%37)O)[C@H]([C@H](O)[C@@H](CO)O%36)O)[C@H]([C@H](O)[C@@H](CO)O%35)O)[C@H]([C@H](O)[C@@H](CO)O%34)O)[C@H]([C@H](O)[C@@H](CO)O%33)O)[C@H]([C@H](O)[C@@H](CO)O%32)O)[C@H]([C@H](O)[C@@H](CO)O%31)O)[C@H]([C@H](O)[C@@H](CO)O%30)O)[C@H]([C@H](O)[C@@H](CO)O%29)O)[C@H]([C@H](O)[C@@H](CO)O%28)O)[C@H]([C@H](O)[C@@H](CO)O%27)O)[C@H]([C@H](O)[C@@H](CO)O%26)O)[C@H]([C@H](O)[C@@H](CO)O%25)O)[C@H]([C@H](O)[C@@H](CO)O%24)O)[C@H]([C@H](O)[C@@H](CO)O%23)O)[C@H]([C@H](O)[C@@H](CO)O%22)O)[C@H]([C@H](O)[C@@H](CO)O%21)O)[C@H]([C@H](O)[C@@H](CO)O%20)O)[C@H]([C@H](O)[C@@H](CO)O%19)O)[C@H]([C@H](O)[C@@H](CO)O%18)O)[C@H]([C@H](O)[C@@H](CO)O%17)O)[C@H]([C@H](O)[C@@H](CO)O%16)O)[C@H]([C@H](O)[C@@H](CO)O%15)O)[C@H]([C@H](O)[C@@H](CO)O%14)O)[C@H]([C@H](O)[C@@H](CO)O%13)O)[C@H]([C@H](O)[C@@H](CO)O%12)O)[C@H]([C@H](O)[C@@H](CO)O%11)O)[C@H]([C@H](O)[C@@H](CO)O%10)O)[C@H]([C@H](O)[C@@H](CO)O9)O)[C@H]([C@H](O)[C@@H](CO)O8)O)[C@H]([C@H](O)[C@@H](CO)O7)O)[C@H]([C@H](O)[C@@H](CO)O6)O)[C@H]([C@H](O)[C@@H](CO)O5)O)[C@H]([C@H](O)[C@@H](CO)O4)O)[C@H]([C@H](O)[C@@H](CO)O3)O)[C@H]([C@H](O)[C@@H](CO)O2)O)[C@@H](O)[C@H](O)[C@@H](CO)O1 JYJIGFIDKWBXDU-MNNPPOADSA-N 0.000 claims description 2
- 229940119170 jojoba wax Drugs 0.000 claims description 2
- 239000011259 mixed solution Substances 0.000 claims description 2
- JXTPJDDICSTXJX-UHFFFAOYSA-N n-Triacontane Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCC JXTPJDDICSTXJX-UHFFFAOYSA-N 0.000 claims description 2
- 239000010466 nut oil Substances 0.000 claims description 2
- 239000004006 olive oil Substances 0.000 claims description 2
- 235000008390 olive oil Nutrition 0.000 claims description 2
- 229920002401 polyacrylamide Polymers 0.000 claims description 2
- 229920001296 polysiloxane Polymers 0.000 claims description 2
- 235000010241 potassium sorbate Nutrition 0.000 claims description 2
- 239000004302 potassium sorbate Substances 0.000 claims description 2
- 229940069338 potassium sorbate Drugs 0.000 claims description 2
- 230000001105 regulatory effect Effects 0.000 claims description 2
- 229940057910 shea butter Drugs 0.000 claims description 2
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 claims description 2
- 235000010234 sodium benzoate Nutrition 0.000 claims description 2
- 239000004299 sodium benzoate Substances 0.000 claims description 2
- 229940032094 squalane Drugs 0.000 claims description 2
- 229960004217 benzyl alcohol Drugs 0.000 claims 1
- 229960003885 sodium benzoate Drugs 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 29
- 230000037303 wrinkles Effects 0.000 abstract description 23
- 102000003425 Tyrosinase Human genes 0.000 abstract description 19
- 108060008724 Tyrosinase Proteins 0.000 abstract description 19
- 239000002537 cosmetic Substances 0.000 abstract description 11
- 230000001976 improved effect Effects 0.000 abstract description 8
- 230000002195 synergetic effect Effects 0.000 abstract description 7
- 230000009286 beneficial effect Effects 0.000 abstract description 4
- 230000002401 inhibitory effect Effects 0.000 abstract description 4
- 239000002085 irritant Substances 0.000 abstract description 4
- 231100000021 irritant Toxicity 0.000 abstract description 4
- 239000000686 essence Substances 0.000 description 45
- 210000003491 skin Anatomy 0.000 description 41
- 230000000052 comparative effect Effects 0.000 description 38
- 238000012360 testing method Methods 0.000 description 19
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 description 14
- 239000000523 sample Substances 0.000 description 13
- 230000005764 inhibitory process Effects 0.000 description 12
- 239000000243 solution Substances 0.000 description 12
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 8
- 229920002674 hyaluronan Polymers 0.000 description 8
- 229960003160 hyaluronic acid Drugs 0.000 description 8
- 238000006243 chemical reaction Methods 0.000 description 6
- 230000031700 light absorption Effects 0.000 description 6
- WTDRDQBEARUVNC-LURJTMIESA-N L-DOPA Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C(O)=C1 WTDRDQBEARUVNC-LURJTMIESA-N 0.000 description 5
- 230000003020 moisturizing effect Effects 0.000 description 5
- 206010061218 Inflammation Diseases 0.000 description 4
- 244000106592 Magnolia alba Species 0.000 description 4
- 241001081203 Verbena Species 0.000 description 4
- 235000007212 Verbena X moechina Moldenke Nutrition 0.000 description 4
- 235000001594 Verbena polystachya Kunth Nutrition 0.000 description 4
- 235000007200 Verbena x perriana Moldenke Nutrition 0.000 description 4
- 235000002270 Verbena x stuprosa Moldenke Nutrition 0.000 description 4
- 238000002835 absorbance Methods 0.000 description 4
- 230000032683 aging Effects 0.000 description 4
- 230000001476 alcoholic effect Effects 0.000 description 4
- 238000006911 enzymatic reaction Methods 0.000 description 4
- 229940045761 evening primrose extract Drugs 0.000 description 4
- 235000008524 evening primrose extract Nutrition 0.000 description 4
- 238000002474 experimental method Methods 0.000 description 4
- 230000001815 facial effect Effects 0.000 description 4
- 230000009467 reduction Effects 0.000 description 4
- 150000003384 small molecules Chemical class 0.000 description 4
- 239000002904 solvent Substances 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- 239000004408 titanium dioxide Substances 0.000 description 4
- AHMIDUVKSGCHAU-UHFFFAOYSA-N Dopaquinone Natural products OC(=O)C(N)CC1=CC(=O)C(=O)C=C1 AHMIDUVKSGCHAU-UHFFFAOYSA-N 0.000 description 3
- 241000196324 Embryophyta Species 0.000 description 3
- AHMIDUVKSGCHAU-LURJTMIESA-N L-dopaquinone Chemical compound [O-]C(=O)[C@@H]([NH3+])CC1=CC(=O)C(=O)C=C1 AHMIDUVKSGCHAU-LURJTMIESA-N 0.000 description 3
- 241000244359 Ligusticum jeholense Species 0.000 description 3
- 206010067482 No adverse event Diseases 0.000 description 3
- 208000002193 Pain Diseases 0.000 description 3
- 230000003712 anti-aging effect Effects 0.000 description 3
- 230000008901 benefit Effects 0.000 description 3
- 239000008367 deionised water Substances 0.000 description 3
- 229910021641 deionized water Inorganic materials 0.000 description 3
- CBMPTFJVXNIWHP-UHFFFAOYSA-L disodium;hydrogen phosphate;2-hydroxypropane-1,2,3-tricarboxylic acid Chemical compound [Na+].[Na+].OP([O-])([O-])=O.OC(=O)CC(O)(C(O)=O)CC(O)=O CBMPTFJVXNIWHP-UHFFFAOYSA-L 0.000 description 3
- 238000011156 evaluation Methods 0.000 description 3
- 238000010438 heat treatment Methods 0.000 description 3
- 230000004054 inflammatory process Effects 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 230000036407 pain Effects 0.000 description 3
- 230000000144 pharmacologic effect Effects 0.000 description 3
- 229920001282 polysaccharide Polymers 0.000 description 3
- 239000005017 polysaccharide Substances 0.000 description 3
- 230000003405 preventing effect Effects 0.000 description 3
- 230000008439 repair process Effects 0.000 description 3
- 238000011160 research Methods 0.000 description 3
- 239000012488 sample solution Substances 0.000 description 3
- 241000894006 Bacteria Species 0.000 description 2
- 244000286838 Eclipta prostrata Species 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 241000244365 Ligusticum sinense Species 0.000 description 2
- XUMBMVFBXHLACL-UHFFFAOYSA-N Melanin Chemical compound O=C1C(=O)C(C2=CNC3=C(C(C(=O)C4=C32)=O)C)=C2C4=CNC2=C1C XUMBMVFBXHLACL-UHFFFAOYSA-N 0.000 description 2
- 206010030113 Oedema Diseases 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
- 208000003251 Pruritus Diseases 0.000 description 2
- 206010037660 Pyrexia Diseases 0.000 description 2
- 208000025865 Ulcer Diseases 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 2
- 239000003963 antioxidant agent Substances 0.000 description 2
- 239000000872 buffer Substances 0.000 description 2
- ZYGHJZDHTFUPRJ-UHFFFAOYSA-N coumarin Chemical compound C1=CC=C2OC(=O)C=CC2=C1 ZYGHJZDHTFUPRJ-UHFFFAOYSA-N 0.000 description 2
- ZSWFCLXCOIISFI-UHFFFAOYSA-N cyclopentadiene Chemical compound C1C=CC=C1 ZSWFCLXCOIISFI-UHFFFAOYSA-N 0.000 description 2
- 210000004207 dermis Anatomy 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 238000000605 extraction Methods 0.000 description 2
- 230000006870 function Effects 0.000 description 2
- 150000004676 glycans Chemical class 0.000 description 2
- 230000001965 increasing effect Effects 0.000 description 2
- 230000007803 itching Effects 0.000 description 2
- 150000002605 large molecules Chemical class 0.000 description 2
- 229920002521 macromolecule Polymers 0.000 description 2
- 201000004792 malaria Diseases 0.000 description 2
- 230000008099 melanin synthesis Effects 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- YLGYACDQVQQZSW-UHFFFAOYSA-N n,n-dimethylprop-2-enamide Chemical compound CN(C)C(=O)C=C YLGYACDQVQQZSW-UHFFFAOYSA-N 0.000 description 2
- 201000009240 nasopharyngitis Diseases 0.000 description 2
- 230000003647 oxidation Effects 0.000 description 2
- 238000007254 oxidation reaction Methods 0.000 description 2
- 230000001717 pathogenic effect Effects 0.000 description 2
- 150000008442 polyphenolic compounds Chemical class 0.000 description 2
- 235000013824 polyphenols Nutrition 0.000 description 2
- 230000001737 promoting effect Effects 0.000 description 2
- 150000003254 radicals Chemical class 0.000 description 2
- 231100000430 skin reaction Toxicity 0.000 description 2
- FWFUWXVFYKCSQA-UHFFFAOYSA-M sodium;2-methyl-2-(prop-2-enoylamino)propane-1-sulfonate Chemical compound [Na+].[O-]S(=O)(=O)CC(C)(C)NC(=O)C=C FWFUWXVFYKCSQA-UHFFFAOYSA-M 0.000 description 2
- 230000004936 stimulating effect Effects 0.000 description 2
- 229940104261 taurate Drugs 0.000 description 2
- XOAAWQZATWQOTB-UHFFFAOYSA-N taurine Chemical compound NCCS(O)(=O)=O XOAAWQZATWQOTB-UHFFFAOYSA-N 0.000 description 2
- 230000002936 tranquilizing effect Effects 0.000 description 2
- 231100000397 ulcer Toxicity 0.000 description 2
- OYHQOLUKZRVURQ-NTGFUMLPSA-N (9Z,12Z)-9,10,12,13-tetratritiooctadeca-9,12-dienoic acid Chemical compound C(CCCCCCC\C(=C(/C\C(=C(/CCCCC)\[3H])\[3H])\[3H])\[3H])(=O)O OYHQOLUKZRVURQ-NTGFUMLPSA-N 0.000 description 1
- IQVQXVFMNOFTMU-FLIBITNWSA-N (Z)-ligustilide Chemical compound C1CC=CC2=C1C(=C/CCC)/OC2=O IQVQXVFMNOFTMU-FLIBITNWSA-N 0.000 description 1
- 241001278836 Agrimonia pilosa Species 0.000 description 1
- 235000000641 Agrimonia pilosa Nutrition 0.000 description 1
- 241000208173 Apiaceae Species 0.000 description 1
- 208000006820 Arthralgia Diseases 0.000 description 1
- 241001106067 Atropa Species 0.000 description 1
- 238000012935 Averaging Methods 0.000 description 1
- 102000008186 Collagen Human genes 0.000 description 1
- 108010035532 Collagen Proteins 0.000 description 1
- 208000035473 Communicable disease Diseases 0.000 description 1
- 241000195493 Cryptophyta Species 0.000 description 1
- 208000005171 Dysmenorrhea Diseases 0.000 description 1
- 206010013935 Dysmenorrhoea Diseases 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- 206010019233 Headaches Diseases 0.000 description 1
- 206010023126 Jaundice Diseases 0.000 description 1
- WTDRDQBEARUVNC-UHFFFAOYSA-N L-Dopa Natural products OC(=O)C(N)CC1=CC=C(O)C(O)=C1 WTDRDQBEARUVNC-UHFFFAOYSA-N 0.000 description 1
- 229920002097 Lichenin Polymers 0.000 description 1
- 201000005505 Measles Diseases 0.000 description 1
- 239000004909 Moisturizer Substances 0.000 description 1
- 241000159443 Myrcia Species 0.000 description 1
- 241000219926 Myrtaceae Species 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 1
- 208000004880 Polyuria Diseases 0.000 description 1
- 206010040914 Skin reaction Diseases 0.000 description 1
- 208000005392 Spasm Diseases 0.000 description 1
- 241001073567 Verbenaceae Species 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- IQVQXVFMNOFTMU-DHZHZOJOSA-N Z-ligustilide Natural products C1CC=CC2=C1C(=C/CCC)\OC2=O IQVQXVFMNOFTMU-DHZHZOJOSA-N 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 1
- 230000036592 analgesia Effects 0.000 description 1
- 230000002155 anti-virotic effect Effects 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 235000019658 bitter taste Nutrition 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 238000005282 brightening Methods 0.000 description 1
- 239000007853 buffer solution Substances 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 230000004663 cell proliferation Effects 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 229920001436 collagen Polymers 0.000 description 1
- 229960000956 coumarin Drugs 0.000 description 1
- 235000001671 coumarin Nutrition 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 239000000287 crude extract Substances 0.000 description 1
- 239000007933 dermal patch Substances 0.000 description 1
- 230000004069 differentiation Effects 0.000 description 1
- 230000003467 diminishing effect Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 230000035619 diuresis Effects 0.000 description 1
- 208000001848 dysentery Diseases 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 210000001339 epidermal cell Anatomy 0.000 description 1
- 238000005562 fading Methods 0.000 description 1
- 229930003935 flavonoid Natural products 0.000 description 1
- 235000017173 flavonoids Nutrition 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 210000000232 gallbladder Anatomy 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 231100000869 headache Toxicity 0.000 description 1
- 230000036074 healthy skin Effects 0.000 description 1
- 230000002439 hemostatic effect Effects 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 229960004502 levodopa Drugs 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 230000001050 lubricating effect Effects 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 230000000873 masking effect Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000002175 menstrual effect Effects 0.000 description 1
- 230000001333 moisturizer Effects 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000012466 permeate Substances 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 230000035755 proliferation Effects 0.000 description 1
- 235000019633 pungent taste Nutrition 0.000 description 1
- 230000035484 reaction time Effects 0.000 description 1
- 230000002829 reductive effect Effects 0.000 description 1
- 230000008929 regeneration Effects 0.000 description 1
- 238000011069 regeneration method Methods 0.000 description 1
- 210000002345 respiratory system Anatomy 0.000 description 1
- 201000005404 rubella Diseases 0.000 description 1
- 238000011076 safety test Methods 0.000 description 1
- 238000009781 safety test method Methods 0.000 description 1
- 230000009759 skin aging Effects 0.000 description 1
- 230000008591 skin barrier function Effects 0.000 description 1
- 230000037394 skin elasticity Effects 0.000 description 1
- 206010040872 skin infection Diseases 0.000 description 1
- 230000035483 skin reaction Effects 0.000 description 1
- 150000003431 steroids Chemical class 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 230000031068 symbiosis, encompassing mutualism through parasitism Effects 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 230000001256 tonic effect Effects 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 230000008736 traumatic injury Effects 0.000 description 1
- 150000003648 triterpenes Chemical class 0.000 description 1
- 239000000341 volatile oil Substances 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 238000003809 water extraction Methods 0.000 description 1
Classifications
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Cosmetics (AREA)
Abstract
The invention discloses whitening and anti-wrinkle essence and a preparation method thereof, and relates to the technical field of whitening cosmetics. The whitening anti-wrinkle composition comprises the following raw materials in parts by weight: 0.001 to 0.1 portion of schizonepeta spike extract, 0.002 to 0.2 portion of lichen extract, 0.01 to 0.24 portion of verbena extract, 0.05 to 0.3 portion of myrtle leaf extract, 0.003 to 0.1 portion of Chinese ligusticum rhizome extract and 0.01 to 0.1 portion of sodium hyaluronate. According to the invention, the specific synergistic effect among the components is utilized, so that the wrinkle of the skin is greatly improved, and the wrinkle-resistant effect is obvious. The whitening and anti-wrinkle composition provided by the invention is beneficial to improving the skin smoothness of a user, and has an obvious whitening effect. The prepared essence has the obvious effect of inhibiting tyrosinase, is mild in quality, safe and non-irritant, and has an obvious anti-wrinkle effect and a whitening effect.
Description
Technical Field
The invention relates to the technical field of whitening cosmetics, and particularly relates to whitening and anti-wrinkle essence and a preparation method thereof.
Background
Currently, whitening is mostly performed by physical concealer treatment using cosmetics containing titanium dioxide. The titanium dioxide is added into a certain substrate and uniformly coated on the face, the high reflection of the titanium dioxide to light is utilized to improve the brightness of the skin, and meanwhile, the titanium dioxide also fills in wrinkles on the surface of the skin, so that the effect of covering the wrinkles of the skin is achieved. However, such physical masking does not solve the problems of dullness and increased wrinkles from the viewpoint of the skin itself, and does not effectively delay the aging process of the skin. In addition, a laser spot removing method is adopted by some people, the method is expensive, spots are blackened, inflammation or more spread occurs, and the mild spot-lightening and spot-removing effects cannot be achieved.
Patent application with patent publication number CN 110151617A discloses an extraction process of myrtle extracting solution and application thereof, and the obtained myrtle-containing anti-wrinkle essence has the characteristics of resisting wrinkles and preventing skin aging. However, the essence has no whitening effect.
In view of this, the invention is particularly proposed.
Disclosure of Invention
The invention aims to provide an essence capable of whitening skin and resisting wrinkles and a preparation method thereof, and provides the essence capable of whitening skin and resisting wrinkles.
The invention is realized by the following steps:
in a first aspect, the invention provides a whitening and anti-wrinkle composition, which comprises the following raw materials in parts by weight: 0.001 to 0.1 portion of schizonepeta spike extract, 0.002 to 0.2 portion of lichen extract, 0.01 to 0.24 portion of verbena extract, 0.05 to 0.3 portion of myrtle leaf extract, 0.003 to 0.1 portion of ligusticum Liaoning extract and 0.01 to 0.1 portion of sodium hyaluronate.
The composition comprises herba Schizonepetae extract, lichen extract, herba Verbenae extract, myrtle leaf extract, ligusticum jezoides extract and sodium hyaluronate, and has skin whitening and wrinkle removing effects. The specific synergistic effect among the components enables the wrinkles of the skin to be improved to a great extent, and the anti-wrinkle effect is obvious. The whitening and anti-wrinkle composition provided by the invention is beneficial to improving the skin smoothness of a user, and has an obvious whitening effect.
Wherein the herba Schizonepetae extract is obtained from water or alcoholic solution of dry herba Schizonepetae. Herba Schizonepetae, pungent in flavor, slightly warm, entering liver and lung channels, has effects of relieving exterior syndrome, dispelling pathogenic wind, promoting eruption, and eliminating sore, and can be used for treating common cold, headache, measles, rubella, and pyocutaneous disease; modern pharmacological research shows that schizonepeta spike has the functions of antipyresis, anti-inflammation, analgesia, itching relieving and antivirus.
In the present invention, the moss extract is derived from an aqueous or alcoholic solution extract of moss. Lichen is a complex formed by symbiosis of fungi and algae, and has a long history in China, and the main active ingredients of lichen are lichen polysaccharide, allopatric lichen polysaccharide, beta-lichen phenol and lichenin, and the lichen has various biological activities of moisturizing, improving skin elasticity, fading texture, improving skin darkness, resisting oxidation, resisting tumors, resisting viruses, resisting bacteria and the like.
In the present invention, the verbena extract is derived from an aqueous or alcoholic solution of verbena. Herba Verbenae, also known as Spiranthis Praecocis, herba Schizonepetae, and Agrimonia pilosa, is dried aerial part of herba Verbenae of Verbenaceae, and is grown for many years, and dried whole herb or whole herb with root is used as medicine, and has light smell and slightly bitter taste; the main functional components are triterpenes, steroids, flavonoid polysaccharide, verbena, and the like, and the medicine has the effects of clearing away heat and toxic materials, promoting blood circulation and stimulating the menstrual flow, inducing diuresis and reducing edema, and preventing malaria, and is used for treating cold and fever, jaundice, dysentery, dysmenorrhea, edema, malaria, traumatic injury, and the like. In skin care, the cream can regulate water-oil balance, so that pores are compacted, and then the skin is firmer; in addition, the verbena also has strong antioxidant and anti-aging effects, and researches show that the verbena has good B16 cell proliferation inhibition effect.
In the present invention, the myrtle leaf extract is derived from an aqueous or alcoholic solution of myrtle leaves. Myrtle, also known as cyclopentadiene and myrcia, is a evergreen shrub of myrtle of Myrtaceae, and has astringent, tranquilizing, hemostatic, and tonic effects; can be used for treating digestive tract, respiratory tract and various infectious diseases by oral administration, and can be used for treating various skin infections, ulcer, etc. by external application; the myrtle leaves contain more plant polyphenol substances, and the plant polyphenol substances are natural strong reducing substances and have the characteristics of being stronger than common antioxidants in the aspects of oxidation resistance and free radical removal.
In the invention, the Ligusticum jeholense extract is derived from the water or alcohol solution extract of Ligusticum jeholense. Ligusticum jezoides, also named family Ligusticum sinense, etc. is the dried rhizome and root of Ligusticum jezoides of Umbelliferae, and contains linoleic acid, ligustilide, and coumarin; has pungent taste and warm nature, has effects of dispelling pathogenic wind, dispelling cold, eliminating dampness, and relieving pain, and can be used for treating wind-cold type common cold, belladonna pain, and rheumatism arthralgia; modern pharmacological experiments prove that the ligusticum sinense has various pharmacological effects of resisting inflammation, easing pain, tranquilizing, relieving fever, relieving spasm, resisting ulcer, benefiting gallbladder, resisting bacteria and the like. It is commonly used in ancient medical books for whitening skin, lightening spots and brightening.
According to the invention, the sodium hyaluronate is composed of different molecular weights, and researches show that the sodium hyaluronate with different molecular weights has obvious physiological action difference, the sodium hyaluronate with large molecular weight has strong water locking capacity and has the effect of moisturizing the skin, and the sodium hyaluronate with small molecular weight can penetrate into the dermis of the skin to achieve deep water replenishing, even exert the effects of repairing cuticle forming cells, stimulating the regeneration of collagen and restoring and resisting aging. Hyaluronic acid with large and small molecular weights can synergistically enhance the moisturizing and anti-aging effects.
Sodium hyaluronate has several effects as follows: (1) moisture retention. The moisturizing effect is the most important effect of sodium hyaluronate in cosmetics, and compared with other moisturizers, the sodium hyaluronate has the highest moisture absorption capacity in a low-humidity environment and the lowest moisture absorption capacity in a high-humidity environment, and the unique property can meet the requirements of skin on the moisturizing effect of cosmetics in different seasons and different environmental humidities. (2) has nourishing effect. The sodium hyaluronate is a biological substance inherent in a human body, and is supplemented by exogenous sodium hyaluronate to human endogenous hyaluronic acid. (3) repairing and preventing effects. Sodium hyaluronate can promote proliferation and differentiation of epidermal cells, scavenge oxygen free radicals, and regenerate damaged skin. (4) lubricity and film-forming properties. After being coated on the skin, the sodium hyaluronate can form a layer of film on the surface of the skin, so that the skin can generate good smooth feeling and lubricating feeling, and the sodium hyaluronate plays a role in protecting the skin.
In the invention, the schizonepeta spike extract mainly has the functions of diminishing inflammation and relieving itching, and the schizonepeta spike extract and the hyaluronic acid are mixed and matched with at least one or two of other extracts (lichen extract, verbena extract, myrtle leaf extract and ligusticum Liaoning extract), so that the whitening, anti-aging, repairing and synergistic effects can be achieved.
In an alternative embodiment, the spica schizonepetae extract, the lichen extract, the verbena extract, the myrtle leaf extract and the ligusticum Liaoning extract are all in a transparent liquid state.
The above extracts include, but are not limited to, extracts obtained by water extraction, alcohol extraction, etc. Including but not limited to crude extracts, fine extracts.
In a preferred embodiment of the invention, the sodium hyaluronate comprises two sodium hyaluronate of different molecular weights: macromolecular sodium hyaluronate with the molecular weight of 200-500 ten thousand daltons and micromolecular sodium hyaluronate with the molecular weight of 500-1000 daltons, wherein the mass ratio of the macromolecular sodium hyaluronate to the micromolecular sodium hyaluronate is 1:1-5.
The large molecular hyaluronic acid and the small molecular hyaluronic acid are compounded, so that the large molecular hyaluronic acid can retain water and supplement water, and the small molecular hyaluronic acid can quickly permeate into a dermis layer to play the effects of repairing and resisting aging. The combination of the two greatly improves the skin barrier and repairs and resists aging.
The mass ratio of the macromolecular sodium hyaluronate to the micromolecular sodium hyaluronate is 1:1, or 1:2, or 1:3, or 1:4 or 1:5. The inventors found that continuing to increase the mass ratio of small molecules (beyond 1:5), the efficiency was not significant, and that small molecule hyaluronic acid was not cost effective with increasing ratio due to its higher price.
In a second aspect, the invention also provides a whitening and anti-wrinkle essence which comprises the following raw materials in parts by weight: 5.2 to 25 portions of water phase, 1 to 5 portions of the whitening and anti-wrinkle composition, 1 to 5 portions of skin moistening phase, 0.1 to 1 portion of preservative and 0.001 to 0.1 portion of aromatic (selected from natural essential oil and/or synthetic essence).
The essence provided by the invention has the obvious effect of inhibiting tyrosinase, is mild in quality, safe and non-irritant, and has an obvious anti-wrinkle effect and a whitening effect.
The whitening and anti-wrinkle essence comprises the following raw materials in parts by weight: 6 to 20 portions of water phase, 1 to 5 portions of the whitening and anti-wrinkle composition, 1 to 5 portions of skin moistening phase, 0.1 to 1 portion of preservative and 0.01 to 0.1 portion of aromatic.
In a preferred embodiment of the application of the present invention, the aqueous phase comprises the following raw materials in parts by weight: 1 to 2 parts of diglycerin, 1 to 10 parts of glycerol, 0.1 to 1 part of xanthan gum, 1 to 5 parts of emulsifier, 2 to 5 parts of fucooligosaccharide and 0.1 to 2 parts of thickener.
In a preferred embodiment of the present invention, the emulsifier is selected from at least one of lecithin, inulin lauryl carbamate, cetearyl olive oleate, sorbitan olive oleate, cetearyl glucoside, C12-20 alkyl glucoside and methyl glucose sesquistearate.
In a preferred embodiment of the invention, the thickener is at least one selected from the group consisting of ammonium acryloyldimethyltaurate/VP copolymer, carbomer and polyacrylamide.
In an alternative embodiment, the thickener is selected from the group consisting of ammonium acryloyl dimethyl taurate/VP copolymer.
In a preferred embodiment of the present invention, the emollient phase is selected from the group consisting of: one or more of shea butter, avocado oil, coconut oil, jojoba oil, macadamia nut oil, egg oil, arnebia oil, squalane, olive oil, silicone, and cetyl ethylhexanoate;
the siloxane is selected from water soluble polydimethylsiloxane.
In a preferred embodiment of the application of the invention, the preservative is selected from at least one of phenoxyethanol, ethylhexyl glycerol, potassium sorbate, sodium benzoate and benzyl alcohol;
in an alternative embodiment, the preservative is selected from phenoxyethanol and ethylhexylglycerin.
The whitening anti-wrinkle essence comprises the following raw materials in parts by weight: 1-2 parts of diglycerol, 1-10 parts of glycerol, 0.1-1 part of xanthan gum, 1-5 parts of lecithin, 2-5 parts of fucooligosaccharide and 0.1-2 parts of acryloyl dimethyl taurate/VP copolymer;
whitening and anti-wrinkle composition: 0.001 to 0.1 portion of schizonepeta spike extract, 0.002 to 0.2 portion of lichen extract, 0.01 to 0.24 portion of verbena extract, 0.05 to 0.3 portion of myrtle leaf extract, 0.003 to 0.1 portion of Chinese ligusticum rhizome extract and 0.01 to 0.1 portion of sodium hyaluronate;
and (3) a skin moistening phase: 1-5 parts of water-soluble polydimethylsiloxane;
0.1 to 1 portion of mixture of preservative phenoxyethanol and ethylhexyl glycerin and 0.001 to 0.1 portion of aromatic.
In a third aspect, the invention also provides a preparation method of the essence, which comprises the following steps:
adding the water phase into water, stirring and homogenizing, regulating the temperature of the mixed solution to 80-85 ℃, and preserving heat; then cooling to 50-55 ℃, adding the whitening and anti-wrinkle composition dispersed by glycerol, and continuously stirring uniformly; cooling to 40-45 ℃, adding the skin moistening phase, stirring, cooling to 38-40 ℃, adding the preservative and the aromatic, and stirring to obtain the essence.
Under the conditions, the whitening and anti-wrinkle essence can be quickly and simply prepared. The raw materials for preparing the essence are added and mixed in batches, and the preparation temperature is controlled, so that the obtained essence has the advantages of clear effect, safety, no adverse reaction, wrinkle resistance, repair and whitening.
In the preferred embodiment of the invention, the water phase is added into water with the temperature of 80-85 ℃, stirred and homogenized, and then the temperature is kept for 20-30 minutes.
The invention has the following beneficial effects:
the efficacy composition provided by the invention consists of schizonepeta spike extract, lichen extract, verbena extract, myrtle leaf extract, ligusticum Liaoning extract and sodium hyaluronate, and has whitening and anti-wrinkle effects. The specific synergistic effect among the components enables the wrinkles of the skin to be greatly improved, and the anti-wrinkle effect is obvious. The whitening and anti-wrinkle composition provided by the invention is beneficial to improving the skin smoothness of a user, and has an obvious whitening effect.
The prepared essence has the remarkable effect of inhibiting tyrosinase, is mild, safe and non-irritant in quality, and has the obvious effects of improving the anti-wrinkle effect and the whitening effect.
In addition, the preparation method of the essence is provided, and the essence with whitening and anti-wrinkle effects can be quickly and simply prepared by the preparation method. The raw materials for preparing the essence are added and mixed in batches, and the preparation temperature is controlled, so that the obtained essence has the advantages of clear effect, safety, no adverse reaction, wrinkle resistance, repair and whitening.
Detailed Description
In order to make the objects, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below. The examples, in which specific conditions are not specified, were conducted under conventional conditions or conditions recommended by the manufacturer. The reagents or instruments used are not indicated by the manufacturer, and are all conventional products available commercially.
The features and properties of the present invention are described in further detail below with reference to examples.
Example 1
The whitening and anti-wrinkle essence comprises the following components:
water phase: 1.5 parts of diglycerol, 7 parts of glycerol, 0.1 part of xanthan gum, 2 parts of lecithin, 2 parts of fucooligosaccharide and 0.9 part of acryloyl dimethyl taurate/VP copolymer;
whitening anti-wrinkle composition (efficacy composition): 0.01 part of schizonepeta spike extract, 0.06 part of lichen extract, 0.1 part of verbena extract, 0.16 part of myrtle leaf extract, 0.05 part of ligusticum Liaoning extract and 0.06 part of sodium hyaluronate (the mass ratio of 200-500 kilodalton macromolecular sodium hyaluronate to 500-1000 dalton micromolecular sodium hyaluronate is 1:2);
and (3) a skin moistening phase: 2.5 parts of water-soluble polydimethylsiloxane;
preservative: 0.8 part of a mixture of phenoxyethanol and ethylhexyl glycerol;
0.03 part of aromatic.
The preparation method comprises the following steps:
(1) Adding deionized water into a stirring pot, heating to 83 ℃, sequentially adding the raw materials of the water phase, stirring, homogenizing and then preserving heat for 20 minutes;
(2) Cooling to 55 deg.C, adding the effective composition dispersed with glycerol, and stirring;
(3) And cooling to 45 ℃, adding a skin moistening phase, stirring and cooling to 38 ℃, adding a preservative and an aromatic, and stirring for 30 minutes to obtain the whitening and anti-wrinkle essence liquid.
Example 2
The whitening and anti-wrinkle essence comprises the following components:
water phase: 2 parts of diglycerin, 3 parts of glycerol, 0.15 part of xanthan gum, 1.2 parts of lecithin, 2 parts of fucooligosaccharide and 0.5 part of acryloyl dimethyl ammonium taurate/VP copolymer;
whitening anti-wrinkle composition (efficacy composition): 0.018 parts of schizonepeta spike extract, 0.042 parts of lichen extract, 0.08 parts of verbena extract, 0.2 parts of myrtle leaf extract, 0.062 parts of ligusticum Liaoning extract and 0.03 parts of sodium hyaluronate (the mass ratio of 200-500 ten thousand daltons of macromolecular sodium hyaluronate to 500-1000 daltons of small molecular sodium hyaluronate is 1:1);
and (3) a skin moistening phase: 4.5 parts of water-soluble polydimethylsiloxane;
preservative: 0.6 part of a mixture of phenoxyethanol and ethylhexyl glycerol;
0.02 part of aromatic.
The preparation method comprises the following steps:
(1) Adding deionized water into a stirring pot, heating to 85 ℃, sequentially adding the raw materials of the water phase, stirring, homogenizing and then preserving heat for 20 minutes;
(2) Cooling to 50 deg.C, adding the effective composition dispersed with glycerol, and stirring;
(3) And cooling to 42 ℃, adding a skin moistening phase, stirring and cooling to 38 ℃, adding a preservative and an aromatic, and stirring for 30 minutes to obtain the whitening and anti-wrinkle essence.
Example 3
The whitening anti-wrinkle essence comprises the following components:
water phase: 1.6 parts of diglycerol, 3.8 parts of glycerol, 0.64 part of xanthan gum, 4 parts of lecithin, 5 parts of fucooligosaccharide and 1.6 parts of acryloyl dimethyl ammonium taurate/VP copolymer;
whitening anti-wrinkle composition (efficacy composition): 0.038 part of schizonepeta spike extract, 0.12 part of lichen extract, 0.16 part of verbena extract, 0.2 part of myrtle leaf extract, 0.048 part of ligusticum Liaoning extract and 0.05 part of sodium hyaluronate (the mass ratio of 200-500 million daltons of macromolecular sodium hyaluronate to 500-1000 daltons of small molecular sodium hyaluronate is 1:4);
and (3) a skin moistening phase: 4.0 parts of water-soluble polydimethylsiloxane;
preservative: 0.5 part of a mixture of phenoxyethanol and ethylhexyl glycerol;
0.08 part of aromatic.
The preparation method comprises the following steps:
(1) Adding deionized water into a stirring pot, heating to 80 ℃, sequentially adding the raw materials of the water phase, stirring, homogenizing and then preserving heat for 30 minutes;
(2) Cooling to 52 deg.C, adding the effective composition dispersed with glycerol, and stirring;
(3) And cooling to 42 ℃, adding a skin moistening phase, stirring and cooling to 39 ℃, adding a preservative and an aromatic, and stirring for 30 minutes to obtain the whitening and anti-wrinkle essence.
Comparative example 1
Compared with example 1, the only difference is that: the efficacy composition was replaced with the same amount of schizonepeta spike extract, and the composition and preparation method of the remaining essence were the same as in example 1.
Comparative example 2
Compared with example 1, the difference is only that: the efficacious composition was replaced with equal amounts of lichen extract and the composition and preparation of the remaining essences were the same as in example 1.
Comparative example 3
Compared with example 1, the difference is only that: the composition and preparation method of the other essences were the same as in example 1, except that the effective composition was replaced with the equivalent amount of verbena extract.
Comparative example 4
Compared with example 1, the only difference is that: the efficacy composition was replaced with an equal amount of myrtle leaf extract, and the composition and preparation method of the remaining essence were the same as in example 1.
Comparative example 5
Compared with example 1, the difference is only that: the effective composition was replaced with the equivalent amount of ligusticum Liaoning extract, and the composition and preparation method of the other essence were the same as in example 1.
Comparative example 6
Compared with example 1, the difference is only that: the efficacy composition was replaced with an equal amount of sodium hyaluronate (large molecule: small molecule = 1:2) and the composition and preparation of the remaining serum was the same as in example 1.
Comparative example 7
Compared with example 1, the only difference is that: only the myrtle leaf extract in the efficacy composition was replaced with the same amount of the alpine lupulus extract, and the composition of the remaining efficacy composition, the composition of the essence and the preparation method were the same as in example 1.
Comparative example 8
Compared with example 1, the difference is only that: only the verbena extract in the efficacy composition was replaced with the same amount of magnolia alba extract, and the composition, the composition of the essence and the preparation method of the remaining efficacy composition were the same as in example 1.
Comparative example 9
Compared with example 1, the difference is only that: only the lichen extract in the efficacy composition was replaced with the same amount of evening primrose extract, and the composition, the composition of the essence and the preparation method of the remaining efficacy composition were the same as in example 1.
Experimental example 1
Tyrosinase activity inhibition experiments were performed.
The principle is as follows: tyrosinase is a key enzyme in skin melanin biosynthesis, and acts on dopa to form dopaquinone, which spontaneously undergoes a series of reactions to finally form melanin. Tyrosinase can catalyze the conversion of dopa to dopaquinone in a phosphoric acid solution with pH 6.8, and the absorbance can be measured at 475nm of a spectrophotometer. The raw material with tyrosinase activity inhibition effect can reduce conversion of dopa into dopaquinone, so as to reduce light absorption value, and the inhibition effect of the cosmetic on tyrosinase activity is evaluated according to the change of the light absorption value. Further, the inhibitory effect of the cosmetic on skin melanin production was evaluated.
Preparation of test sample solution: 1mL of each of the essences of example 1, the blank control group and comparative examples 1 to 9 (see Table 1) was taken, diluted 1mL with a disodium hydrogenphosphate-citric acid buffer solution (pH 6.8), and mixed to prepare sample solutions.
TABLE 1 test groups
| Group of | Formulation(s) |
| Blank control group | The functional composition was replaced with an equal amount of glycerin, otherwise as in example 1 |
| Comparative example 1 | The effective composition was replaced with equal amount of herba Schizonepetae extract, as in example 1 |
| Comparative example 2 | Replacing the effective composition with equal amount of lichen extractThe same procedure as in example 1 was repeated |
| Comparative example 3 | The functional composition was replaced by an equal amount of verbena extract, otherwise the same as example 1 |
| Comparative example 4 | The efficacy composition was changed to equal amount of myrtle leaf extract, otherwise as in example 1 |
| Comparative example 5 | The effective composition is replaced by equal amount of Ligusticum jeholense extract, other examples are the same as example 1 |
| Comparative example 6 | The efficacy composition was changed to an equal amount of sodium hyaluronate (large molecule: small molecule = 1:2) and the other examples were the same as example 1 |
| Comparative example 7 | The extract of the leaf of myrtle of phase B was replaced by the same amount of the extract of the leaf of the plant of the same type as that of the leaf of the myrtle of phase B, and the same procedure as that of example 1 was repeated |
| Comparative example 8 | The phase B ingredient herba Verbenae extract is replaced by equal amount of Magnolia alba extract, otherwise the same as example 1 |
| Comparative example 9 | The moss extract of phase B is replaced by the same amount of evening primrose extract, otherwise the same as example 1 |
Use of 10mL test tubes to set up sample tubes (T), sample background (T) 0 ) Enzyme reaction tube (C) and solvent background (C) 0 ) Sample tube (T) and sample background (T) 0 ) In each case add1mL of sample solution, enzyme reaction tube (C) and solvent background (C) 0 ) Then 1mL of disodium hydrogen phosphate-citric acid buffer (see Table 2) was added.
0.5mL of tyrosinase solution (100 u/mL) and sample background (T) were added to each of the sample tube (T) and the enzyme reaction tube (C) 0 ) With background of solvent (C) 0 ) Replace with 0.5mL disodium hydrogen phosphate-citric acid buffer, mix the sample and tyrosinase well, put in 37 ℃ water bath and incubate for 10 minutes. 2mL of levodopa solution (1 mg/mL) was added to each tube in sequence, the reaction time was controlled to 5 minutes per tube, and each tube was immediately transferred to a cuvette and the absorbance was measured at 475 nm.
TABLE 2 sample charging meter
Tyrosinase inhibition rate calculation formula:
in the formula:
t-sample tube light absorption value, namely the light absorption value of the solution after the sample reacts with tyrosinase;
T 0 -sample background absorbance;
c, averaging the light absorption values of the enzyme reaction tube for 3 times, namely the light absorption value of the reaction of tyrosinase and dopa when no sample is added;
C 0 -background absorbance of solvent.
The results of the tyrosinase inhibition experiments are shown in table 3.
TABLE 3 tyrosinase inhibition experiment results
| Serial number | Group of | Inhibition ratio (%) |
| 1 | Example 1 | 72.2±3.54 |
| 2 | Blank control group | 10.5±4.16 |
| 3 | Comparative example 1 | 22.3±5.21 |
| 4 | Comparative example 2 | 35.6±4.83 |
| 5 | Comparative example 3 | 32.7±4.97 |
| 6 | Comparative example 4 | 28.8±3.94 |
| 7 | Comparative example 5 | 29.5±4.52 |
| 8 | Comparative example 6 | 40.1±5.12 |
| 9 | Comparative example 7 | 62.5±3.86 |
| 10 | Comparative example 8 | 58.6±4.37 |
| 11 | Comparative example 9 | 55.9±5.18 |
The results in table 3 show that the essence containing a single component in the same amount has a certain tyrosinase inhibition ability, but the inhibition effect on tyrosinase is not significant, and the inhibition effect on tyrosinase of the essence containing the composition is improved by more than 1 time, which indicates that the composition achieves a synergistic effect. In addition, the myrtle leaf extract, the verbena extract and the lichen extract in the efficacy composition are respectively replaced by the Tianshan eclipta extract, the magnolia alba extract and the evening primrose extract in equal amount, the inhibition effect on tyrosinase is not good as that of the example 1, and the synergy of the efficacy composition with the specific composition provided by the invention is better than that of other extracts.
Experimental example 2
And (5) safety test.
The safety test method comprises the following steps: 90 volunteers were selected, and the whitening and repairing essence liquids of examples 1 to 3 were tested according to the regulation of "human skin patch test" of technical safety standards for cosmetics (2015 edition) (30 in each example), and the skin reaction after 24 hours was observed by naked eyes, and the degree of reaction and the grade were shown in table 4.
TABLE 4 Patch test skin response rating Scale
The test results show that 90 volunteers also showed negative reactions. According to technical standards for cosmetic safety (2015), the evaluation criteria of the patch test of human body, and example 1 has no adverse reaction to human body. The whitening anti-wrinkle essence provided by the invention is mild in quality, safe and non-irritant.
Experimental example 3
And (5) an anti-wrinkle effect test.
Selecting 110 female volunteers with healthy skin, randomly dividing the facial wrinkles or fine lines into 11 groups of 10 persons each; the essences of example 1, blank control and comparative examples 1 to 9 were used, respectively. After 8 weeks of continuous use, the reduction degree of the wrinkle area, the number of wrinkles and the wrinkle depth of the face was evaluated by comparing the results at 0 week with the VISIA skin test apparatus, and the test results are shown in table 5.
Table 5 results of the effect test
| Serial number | Group of | Reduction of wrinkle area/%) | Reduction of number of wrinkles/%) | Reduction of wrinkle depth/%) |
| 1 | Example 1 | 28.0 | 26.5 | 23.1 |
| 2 | Blank control group | 5.2 | 3.8 | 2.5 |
| 3 | Comparative example 1 | 8.3 | 11.0 | 10.6 |
| 4 | Comparative example 2 | 11.6 | 12.3 | 9.1 |
| 5 | Comparative example 3 | 10.5 | 12.4 | 11.9 |
| 6 | Comparative example 4 | 14.3 | 12.5 | 11.6 |
| 7 | Comparative example 5 | 12.8 | 12.3 | 10.7 |
| 8 | Comparative example 6 | 14.8 | 12.9 | 13.4 |
| 9 | Comparative example 7 | 23.2 | 20.6 | 19.5 |
| 10 | Comparative example 8 | 25.8 | 21.3 | 19.8 |
| 11 | Comparative example 9 | 23.9 | 20.8 | 18.3 |
The results in table 5 show that the essence containing a single component in the same amount has a certain anti-wrinkle effect, and can reduce the area or degree of facial wrinkles of a volunteer, but the anti-wrinkle effect is not significant, and the anti-wrinkle effect of the essence containing the composition is significantly improved, which further indicates that the composition can achieve a synergistic effect in anti-wrinkle. The anti-wrinkle effect of the functional composition provided by the invention is inferior to that of the example 1 because the myrtle leaf extract, the verbena extract and the lichen extract in the functional composition are replaced by the Tianshan eclipta extract, the magnolia alba extract and the evening primrose extract correspondingly in equal amount, which shows that the synergistic effect of the functional composition provided by the invention is better than that of other extracts, and the anti-wrinkle effect is reduced because of the replacement of other extracts.
Experimental example 4
And (5) testing the whitening effect.
1) Test method
The volunteers are 40-50 years old, half of both males and females have obvious wrinkles or fine lines on the faces, voluntarily participate in the test, sign an informed consent before the test, cannot use any cosmetics 2 days before the test, and cannot use any cosmetics except for the test sample in the test process. After washing the face with warm water, the whitening and repairing essence of example 1 was applied to one face once in the morning and at night, and the test was conducted for 5 weeks. On the other half of the face, the serum of the blank control group (serum prepared by replacing the efficacy composition with an equivalent amount of glycerin only) was used.
2) Evaluation criteria
The test subjects evaluated their own skin changes.
3) Evaluation results
Through statistics, 90% of the testers evaluate that the facial skin of the testers is greatly improved, and particularly, the facial gloss of the testers is improved, the skin wrinkles are improved, the skin becomes smooth, and the whitening effect is obvious after the whitening and repairing essence is used.
The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention, and various modifications and changes may be made by those skilled in the art. Any modification, equivalent replacement, or improvement made within the spirit and principle of the present invention should be included in the protection scope of the present invention.
Claims (10)
1. The whitening and anti-wrinkle composition is characterized by comprising the following raw materials in parts by weight: 0.001 to 0.1 portion of schizonepeta spike extract, 0.002 to 0.2 portion of lichen extract, 0.01 to 0.24 portion of verbena extract, 0.05 to 0.3 portion of myrtle leaf extract, 0.003 to 0.1 portion of Chinese ligusticum rhizome extract and 0.01 to 0.1 portion of sodium hyaluronate.
2. The whitening and anti-wrinkle composition according to claim 1, wherein the sodium hyaluronate comprises two sodium hyaluronate of different molecular weights: macromolecular sodium hyaluronate with the molecular weight of 200-500 ten thousand daltons and micromolecular sodium hyaluronate with the molecular weight of 500-1000 daltons, wherein the mass ratio of the macromolecular sodium hyaluronate to the micromolecular sodium hyaluronate is 1:1-5.
3. The whitening anti-wrinkle essence is characterized by comprising the following raw materials in parts by weight: 5.2 to 25 parts of water phase, 1 to 5 parts of whitening and anti-wrinkle composition according to claim 1 or 2, 1 to 5 parts of skin moistening phase, 0.1 to 1 part of preservative and 0.001 to 0.1 part of aromatic.
4. The essence of claim 3, wherein the water phase comprises the following raw materials in parts by weight: 1 to 2 parts of diglycerin, 1 to 10 parts of glycerol, 0.1 to 1 part of xanthan gum, 1 to 5 parts of emulsifier, 2 to 5 parts of fucooligosaccharide and 0.1 to 2 parts of thickener.
5. The essence of claim 4, wherein the emulsifier is selected from at least one of lecithin, inulin lauryl carbamate, cetearyl olive oleate, sorbitan olive oleate, cetearyl glucoside, C12-20 alkyl glucoside, and methyl glucose sesquistearate.
6. The serum according to claim 4, characterized in that the thickener is selected from at least one of ammonium acryloyldimethyltaurate/VP copolymer, carbomer and polyacrylamide;
preferably, the thickener is selected from the group consisting of ammonium acryloyldimethyltaurate/VP copolymers.
7. The essence of claim 3, wherein the emollient phase is selected from the group consisting of: one or more of shea butter, avocado oil, coconut oil, jojoba oil, macadamia nut oil, egg oil, arnebia oil, squalane, olive oil, silicone, and cetyl ethylhexanoate;
the siloxane is selected from water-soluble polydimethylsiloxane.
8. The essence of claim 3, wherein the preservative is selected from at least one of phenoxyethanol, ethylhexyl glycerin, potassium sorbate, sodium benzoate, and benzyl alcohol;
preferably, the preservative is selected from phenoxyethanol and ethylhexyl glycerol.
9. The method for preparing the essence according to any one of claims 3 to 8, which comprises the following steps:
adding the water phase into water, stirring and homogenizing, regulating the temperature of the mixed solution to 80-85 ℃, and preserving heat; then cooling to 50-55 ℃, adding the whitening and anti-wrinkle composition dispersed by glycerol, and continuously stirring uniformly; cooling to 40-45 ℃, adding the skin moistening phase, stirring, cooling to 38-40 ℃, adding the preservative and the aromatic, and stirring to obtain the essence.
10. The preparation method of claim 9, wherein the aqueous phase is added to water at 80-85 ℃, stirred, homogenized and then kept for 20-30 minutes.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202310027116.3A CN115869233A (en) | 2023-01-09 | 2023-01-09 | Whitening and anti-wrinkle essence and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202310027116.3A CN115869233A (en) | 2023-01-09 | 2023-01-09 | Whitening and anti-wrinkle essence and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN115869233A true CN115869233A (en) | 2023-03-31 |
Family
ID=85758328
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202310027116.3A Pending CN115869233A (en) | 2023-01-09 | 2023-01-09 | Whitening and anti-wrinkle essence and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN115869233A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116270365A (en) * | 2023-04-28 | 2023-06-23 | 康博士日化集团有限公司 | Freckle-removing plant extract composition and preparation method and application thereof |
| CN117679350A (en) * | 2023-12-13 | 2024-03-12 | 诺德溯源(广州)生物科技有限公司 | Guaiac composition for removing acne marks and smoothing acne pits and application thereof |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109260089A (en) * | 2018-11-08 | 2019-01-25 | 陕西天士力植物药业有限责任公司 | A kind of ching-chieh volatile oil maintenance lotion and preparation method thereof |
| CN109662904A (en) * | 2019-02-14 | 2019-04-23 | 成都市葆姿健康管理有限公司 | It is a kind of to have effects that the skin care compositions of whitening antioxidation and its application and preparation method |
| CN110393689A (en) * | 2019-05-31 | 2019-11-01 | 广东盛美化妆品有限公司 | It is a kind of to have effects that anti-ageing essence composition and preparation method thereof |
| CN111419753A (en) * | 2020-04-28 | 2020-07-17 | 刘科勇 | Preservative-free whitening, freckle-removing and anti-aging ampoule essence and preparation method thereof |
| KR20220026801A (en) * | 2020-08-26 | 2022-03-07 | 한국콜마주식회사 | Cosmetic composition comprising mixed extract of verbena hybrida voss, cyclamen persicum mill. and saintpaulia ionantha h. wendl. for moisturizing the skin |
| CN115252531A (en) * | 2022-08-11 | 2022-11-01 | 睿博斯(北京)生物科技有限公司 | Anti-wrinkle essence and preparation method thereof |
-
2023
- 2023-01-09 CN CN202310027116.3A patent/CN115869233A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109260089A (en) * | 2018-11-08 | 2019-01-25 | 陕西天士力植物药业有限责任公司 | A kind of ching-chieh volatile oil maintenance lotion and preparation method thereof |
| CN109662904A (en) * | 2019-02-14 | 2019-04-23 | 成都市葆姿健康管理有限公司 | It is a kind of to have effects that the skin care compositions of whitening antioxidation and its application and preparation method |
| CN110393689A (en) * | 2019-05-31 | 2019-11-01 | 广东盛美化妆品有限公司 | It is a kind of to have effects that anti-ageing essence composition and preparation method thereof |
| CN111419753A (en) * | 2020-04-28 | 2020-07-17 | 刘科勇 | Preservative-free whitening, freckle-removing and anti-aging ampoule essence and preparation method thereof |
| KR20220026801A (en) * | 2020-08-26 | 2022-03-07 | 한국콜마주식회사 | Cosmetic composition comprising mixed extract of verbena hybrida voss, cyclamen persicum mill. and saintpaulia ionantha h. wendl. for moisturizing the skin |
| CN115252531A (en) * | 2022-08-11 | 2022-11-01 | 睿博斯(北京)生物科技有限公司 | Anti-wrinkle essence and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 孙佳明: ""辽藁本地上部分化学成分研究"", 《中药材》, vol. 34, no. 7, 31 July 2011 (2011-07-31), pages 1057 - 1058 * |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116270365A (en) * | 2023-04-28 | 2023-06-23 | 康博士日化集团有限公司 | Freckle-removing plant extract composition and preparation method and application thereof |
| CN116270365B (en) * | 2023-04-28 | 2024-06-07 | 康博士日化集团有限公司 | Freckle-removing plant extract composition and preparation method and application thereof |
| CN117679350A (en) * | 2023-12-13 | 2024-03-12 | 诺德溯源(广州)生物科技有限公司 | Guaiac composition for removing acne marks and smoothing acne pits and application thereof |
| CN117679350B (en) * | 2023-12-13 | 2024-06-07 | 诺德溯源(广州)生物科技有限公司 | Guaiac composition for removing acne marks and smoothing acne pits and application thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN109106677B (en) | Composition with whitening function and application thereof | |
| CN115869233A (en) | Whitening and anti-wrinkle essence and preparation method thereof | |
| EP3607997A1 (en) | Cosmetic composition comprising an extract of passion flower and edelweiss cells and uses | |
| KR101078888B1 (en) | A cosmetic composition comprising tissue cultured Echinaceae adventitious roots and an preparing method thereof | |
| KR20150030095A (en) | Composition for improving condition of hair and scalp containing Panax ginseng extract and Green tea extract | |
| KR20100087522A (en) | Body detergent composition for moisturizing or soothing the skin containing aloe barbadensis miller extract and althaea officinalis root extract | |
| KR20100006796A (en) | Anti-aging cosmetic composition comprising herb ferment extract | |
| CN114533618A (en) | Whitening and repairing composition and preparation method and application thereof | |
| KR101154772B1 (en) | Cosmetic composition containing the zizyphus jujuba fruit extract and walnut extract for moisturizing effect on the skin | |
| KR20230152511A (en) | Cosmetic composition in relieving skin for skin regenerating, Manufacturing method thereof, and Cosmetics containing the same | |
| JP5855949B2 (en) | Keratin production promoter, hair dye and nail polish | |
| KR101214344B1 (en) | Cosmetics composition containing fermented rice bran and licorice extract | |
| CN113143788A (en) | Multi-effect composition and face cream with moisturizing, repairing and relieving functions | |
| KR100537960B1 (en) | Skin anti-aging cosmetics composit containing oriental herb extract and extraction method of the same | |
| CN110755343A (en) | Emulsion for old people and preparation method thereof | |
| KR102504878B1 (en) | cosmetic composition having anti-inflammatory and skin soothing and effects and improvement of skin itching containing fermented extracts of Campsis grandiflora, Plum blossom, Quercus acuta THUNB | |
| KR102686879B1 (en) | Wrinkle and pore improvement composition containing retinol and collagen active ingredients and manufacturing method thereof | |
| KR102052517B1 (en) | Composition for improving condition of hair and scalp containing Panax ginseng polysaccharides and Green tea polysaccharides | |
| CN116459169B (en) | Anti-inflammatory moisturizing skin external composition and preparation method and application thereof | |
| KR102641319B1 (en) | Cosmetic composition having an effect of improving skin barrier and inflammation | |
| KR102063504B1 (en) | Composition for improving condition of hair and scalp containing polysaccharides extracted from Green tea and processed Panax ginseng | |
| KR20050098583A (en) | Cosmetic composition containing polygonatum officinale powder for skin hydrating | |
| KR100507292B1 (en) | A compositions containing Anthriscus sylvestris Hoffmann extract or Petroselinum sativum Miller extract for external application having effects of improving skin wrinkle | |
| KR20160068236A (en) | Composition for improving condition of hair and scalp containing panasenoside | |
| CN114191361A (en) | Freckle removing composition containing yeast fermentation extract and preparation method and application thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| CB03 | Change of inventor or designer information | ||
| CB03 | Change of inventor or designer information |
Inventor after: Chen Manli Inventor after: Zeng Yuanling Inventor after: Tan Zhibiao Inventor after: Wu Fengbi Inventor before: Chen Manli Inventor before: Zeng Yuanling Inventor before: Tan Zhibiao Inventor before: Wu Fengbi Inventor before: Jiang Yanfen Inventor before: Mo Yuanshan |