CN1158258A - Qinyun wound externally used medicine - Google Patents

Abstract

An external-use drug for treating burn, scald, bed sore and knife wound is prepared through boiling sesame oil, addition of Chinese angelica root, slowly decocting until Chinese angelica root becomes scorched slightly, taking scorched Chinese angelica root out and grinding it, dissolving beeswax in boiled sesame oil, shaping, cooling to 40 deg.C, and mixing with borneol, metronidazole powder, spiramycin powder and lidocaine powder to obtain said drug A; or mixing with scorched Chinese angelica root powder and hyoscine to obtain said drug B.

Description

Qin Yun wound medicine for external use

The present invention relates to a kind of medical Qin Yun wound medicine for external use for the treatment of wound.

Existing surgery clinically, postoperative wound infection, burn, decubital ulcer, chilblain and other skin traumas are general adopts clear skin ulcer, stitching; Local use that ethacridine, new gill go out, hydrogen peroxide or some antibiotic water preparation dressing external.To non-infective wound surface, adopt the external application of aseptic vaseline gauze, the healing of giving free rein to.Because traumatic infection, blood circulation is not good enough that healing is delayed, even the disunion of several years several months causes patient's press, even becomes main causes of death.In the surgery of Chinese medicine field, multiple granulation promoting ointment is arranged since its protect from infection or anti-infectious function a little less than, curative effect is not good enough, uses few in the doctor trained in Western medicine surgical field.Cut crust skin-grafting therapy for burn at present, cicatrix is had resectional therapy, but on the wound healing problem, if local blood fortune is bad, traumatic infection all can cause the healing delay situation.

The object of the present invention is to provide a kind of diffusion that can effectively protect from infection or infect for infective wound surface or non-infective wound surface, promptly improve the wound surface blood circulation, remove slough, impel tissue repair, the medical Qin Yun wound medicine for external use that impels various wound faces to heal as early as possible.

Another name Radix Angelicae Sinensis or cloud that the traditional Chinese medical science so-called " Qin Yun " is Radix Angelicae Sinensis are returned, and respectively get a word and form.

The present invention has adopted that Chinese medicine is invigorated blood circulation, pain relieving, expelling the stasis for the new, impel the advantage of tissue repair to add reliable infection outward again, relieve the pain, improve the microcirculatory western medicine composition of tissue local, adjust its composition according to the different phase of wound clinically again, make the Qin Yun sliver, the passive situation of press to change the disunion of a specified duration of the present contaminated wound of doctor trained in Western medicine surgery.It selects for use Chinese medicine angelica, Cera Flava, Oleum Sesami (Oleum sesami), Borneolum Syntheticum to be batching, adds Western medicine scopolamine, metronidazole, lignocaine, spiramycin, and the bitter tepor of its Radix Angelicae Sinensis (old body) property is nontoxic, is used to invigorate blood circulation, enriches blood, moisturizes, regulating menstruation.After Radix Angelicae Sinensis process Oleum Sesami soaks and fries in shallow oil, Radix Angelicae Sinensis has anastalsis to tissue local to its oil preparation with frying in shallow oil afterwards, make skin surrounding tissue vasodilation hyperemia, promote the epithelial tissue growth, the Radix Angelicae Sinensis in vitro tests has inhibitory action to various pathogens such as typhoid fever, dysentery bacterium, staphylococcus etc.Cera Flava is an excipient.But rhagades of the skin, profit sheath skin are put on flesh, subside a swelling, mended to the Oleum Sesami granulation promoting, and suppress the growth of antibacterial.The Borneolum Syntheticum heat clearing away.And Western medicine scopolamine blood vessel dilating, microcirculation improvement; Lignocaine belongs to anesthetics, makes the local woanded surface pain relief; Metronidazole infects effectively anaerobic bacillus(cillus anaerobicus), and spiramycin is effective to the microbial various infection of G (+), is applicable to wound, burn and skin infection.The method of its making is earlier Oleum Sesami to be fried boiling, tableted Radix Angelicae Sinensis is added oil cauldron, to little Jiao of Radix Angelicae Sinensis, then burnt Radix Angelicae Sinensis is pulled out with at a simmer, again burnt Radix Angelicae Sinensis is made the powder smalls, with 600 mesh sieve sieving for standby, again Cera Flava is melted in the Oleum Sesami that boils figuration, former dose of shape, when treating about 40 ℃ of the cool back of former dosage form oil, add Borneolum Syntheticum, metronidazole powder, spiramycin powder, lignocaine powder, it is stirred make the I type, wait to solidify the back dress and close.The part by weight of its each batching is an Oleum Sesami: Radix Angelicae Sinensis: Cera Flava: Borneolum Syntheticum: metronidazole: spiramycin: lignocaine=500: 200: 150: 10: 4: 4: 2.The medicine of method acquisition is applicable to the initial stage of burn, decubital ulcer thus.Infecting serious wound surface, hemorrhoid infection and suppurative otitis media tympanum repairs.When about 40 ℃ of the cool back of former dosage form oil.Add burnt Radix Angelicae Sinensis powder, scopolamine, stir and make the II type, wait to solidify back dress box, the weight ratio of its each batching is an Oleum Sesami: Radix Angelicae Sinensis: Cera Flava: scopolamine=500: 200: 150: 0.8.Be applicable to the healing phase of burn, the reparation of the decubital ulcer of infection basic controlling, wound surface, traumatic perforation of tympanic membrane also is applicable to the healing of chilblain, anal fissure, cicatrix and non-infectious wound or wound surface.

The invention has the advantages that it gets its traditional Chinese medical science unguentum blood circulation promoting and blood stasis dispelling, the advantage that granulation promoting is put on flesh.Get the reliable infection pharmacological properties of its Western medicine, effectively impel wound healing.Zoopery proves: external application Qin Yun is than matched group healing ahead of time, and diversity is remarkable.Clinical trial certificate: it strengthens the local organization blood circulation, and the cytophagous activity of excitation is quickened necrotic tissue cleaning.It has the wound surface of promotion surface texture, hypodermic hypertrophy, healing acceleration, and effectively prevention infection and anti-infectious function overcome the not good shortcoming of other Chinese medicine unguentum anti-infectious functions.Tangible prevention is arranged or alleviate cicatrization, the healing of its wound surface belongs to no crust healing.Also have resisting age of skin and skin care effect.Pharmacological action reliably has extensively suitable disease, as treats various burns, scald and chemical burn, makes depth of burn alleviate, dwindle to greatest extent damaged area, healing acceleration.For the obstinate decubital ulcer, in treatment, shown clear superiority.The healing postoperative wound surface not good to blood fortune, than general processing method healing 2-4 week in advance, natural law 7 ± 1.5 days on average heals.For hemorrhoid, anal fissure, the perforation of ear drum, The treatment of disunion wound surface for a long time of swollen back is better than similar Chinese medicine or Western medicine dosage form.Suppress cicatrization.The softening cicatrix of treatment reduces cicatrization to dark II ° to greatest extent with III ° of burn, keeps normal physiological function.The skin-grafting wound is used this medicine, can make its survival rate height, the flap growth is fast.Also can be made into sliver. I type or II type are put into square plate in right amount, the sliver for preparing is lain in the square plate, autoclave sterilization gets final product the medicine immersion sliver of fusing.But I or II type have been evenly coated on the flexible nonirritant adhesive tape, and the time spent is attached on the wound surface, is suitable for little wounds such as knife injury, scratch, and skin care effect is arranged simultaneously, as former dose 50 gram added cream base matter softener sg 200 grams, perfuming a little.Be suitable for skin care, crease-resistant, antifreeze, make the skin exquisiteness tender and lovely.Putting skin during use on the skin rubs repeatedly to wipe unguentum is gone in the skin.

To I °-II ° (shallow) burn 46 examples, cure 100% clinically, curative day is 6.5 ± 2.5 days.Dark II °-III ° (small size～middle area) burn 32 examples, cure rate 100%.Curative day 24 ± 6.5 days.One routine male l8 year, the paper mill workman is strong * *, fall into the two burn of lower limb l8% in alkali pond accidentally.Wherein dark II ° 8%, III ° of burn 10%.Remove general transfusion, outside infection was handled, situation was cleaned wound surface with normal saline, and III ° of wound surface is that greyish white bag, pain are not obvious, II ° of violent, red and swollen, the ulceration of wound pain.It is thick to use the I type to be coated with wound surface 1mm, reuse I type make the external application of ointment sliver after 10～20 minutes pain alleviate substantially, 72 hours sloughs begin dissolving and are similar to the purulent secretion sheet and come off, two all necrotic tissue cleanings finish, use Qin Yun II type instead, the shallow II ° of existing healing of burn.Dark II ° and III ° of wound surface granulation tissue growth, epidermis and remaining epidermis rapid spread healed in 35 days substantially on every side, healing back skin rubefaction, slight cicatrix area 5.5%, heel continues the external Qin and removes the II type, and firmly smear repeatedly with popliteal nest place all has, make its medicine go into skin, every day 1 time, cicatrix is softening after half a year, and limb function is normal.Treatment decubital ulcer 24 examples 32 places, wound surface size 4～98cm ², I phases 6 example, the II phase 10 examples, 12 places, average cure time 2l ± 5.5, above 8 examples, 14 places (decubital ulcer that has reaches the flesh layer deeply) of III phase day, III phase and above decubital ulcer of III phase (large tracts of land) can delay the 1-2 month.One routine women is because of fracture bed sacrum portion and the formation of buttocks many places decubital ulcer, and III reaches the flesh layer more than the phase deeply, and ethacridine dressing was changed dressings 6 months, and area still is 98cm ², deep tissue is the atrophy surrounding skin and is to skin ulcer face volume shape in the wrong, and the wound surface drying has hemorrhage.Use Qin Yun II type, changed dressings once in per two days, no crust healing in 2 months.For postoperative infection, or the blood fortune wound of disunion for a long time not, 20 examples are all passed through (antibiotic or Chinese medicine unguentum) the still disunion of changing dressings in 2-3 week.Use the Qin Fang external instead, healing accounts for all healings in 80%, 10 day in the week.

The present invention is further described with implementation column below:

The present invention selects Chinese crude drug Radix Angelicae Sinensis (returning body) for use, Cera Flava, pure Oleum sesami, Borneolum Syntheticum and Western medicine east gelsemium henbane are salty, metronidazole, lignocaine, spiramycin is batching, Oleum Sesami is fried boiling in pot, again tableted Radix Angelicae Sinensis (returning body) is added oil cauldron, with at a simmer to little Jiao of Radix Angelicae Sinensis, then burnt Radix Angelicae Sinensis is pulled out, again burnt Radix Angelicae Sinensis is made the thin foam of powder, through with 600 mesh sieve sieving for standby, again Cera Flava is dissolved that figuration becomes former dosage form in the Oleum Sesami that boils, when treating about 40 ℃ of the cool back of former dosage form oil, add Borneolum Syntheticum, metronidazole powder, the spiramycin powder, the lignocaine powder, it is stirred makes I type medicament, and part by weight of each batching of its I type medicament is an Oleum Sesami: Radix Angelicae Sinensis: Cera Flava: Borneolum Syntheticum: metronidazole: spiramycin: lignocaine=500: 200: 150: 10: 4: 4: 2.When about 40 ℃ of the cool back of former dosage form oil, add burnt Radix Angelicae Sinensis powder, scopolamine powder in former dosage form oil in addition, stir and make II type medicament, part by weight of its each batching is an Oleum Sesami: Radix Angelicae Sinensis: Cera Flava: scopolamine=500: 200: 150: 0.8.Clinically 1, II type medicament is used, and can produce positive therapeutic to various wounds.

Claims (1)

1. A kind of Qin Yun wound medicine for external use that is used for the treatment of wound, it selects the Chinese crude drug Radix Angelicae Sinensis for use, Cera Flava, Oleum Sesami, Borneolum Syntheticum and Western medicine scopolamine, metronidazole, lignocaine, spiramycin is batching, it is characterized in that earlier Oleum Sesami being fried boiling, again Radix Angelicae Sinensis is added oil cauldron, with at a simmer to little Jiao of Radix Angelicae Sinensis, then burnt Radix Angelicae Sinensis is pulled out, again burnt Radix Angelicae Sinensis is made the thin foam of powder, through with 600 mesh sieve sieving for standby, again Cera Flava is dissolved that figuration becomes former dosage form in the Oleum Sesami that boils, when treating about 40 ℃ of the cool back of former dosage form oil, add Borneolum Syntheticum, metronidazole powder, the spiramycin powder, the lignocaine powder, it is stirred make I type medicament, the part by weight of its each batching is an Oleum Sesami: return: Cera Flava: Borneolum Syntheticum: metronidazole: spiramycin: lignocaine=500: 200: 150: 10: 4: 4: 2, in addition, when about 40 ℃ of the cool back of former dosage form oil, in former dosage form oil, add burnt Radix Angelicae Sinensis powder, scopolamine, stir and make II type medicament, the part by weight of its each batching is an Oleum Sesami: Radix Angelicae Sinensis: Cera Flava: scopolamine=500: 200: 150: 0.8.