CN115337442A - A kind of medical adhesive glue and its preparation method and application - Google Patents

Abstract

The invention provides a medical adhesive, a preparation method and application thereof. The raw materials for the preparation of the medical adhesive include the following components in parts by weight: 6-50 parts of acrylate polyethylene glycol, 0.2-35 parts of acrylic compound, 0.001-1 part of crosslinking agent and alkaline buffer 0.1‑3 servings. First, mix acrylate polyethylene glycol, acrylic compound, crosslinking agent, initiator and water to obtain mixed solution A; mix the thickener and water to obtain mixed solution B; then mix solutions A and B, After the pH of the mixed solution is adjusted to be between 6-7 by an alkaline buffer, a cross-linking reaction is performed to obtain the medical adhesive. The medical adhesive has high adhesion strength, good fit, good biocompatibility and degradability, and can be used for wound hemostasis, visceral and soft tissue wound sealing and plugging, fibrous annulus fracture Drug carrier for repair or tissue engineering.

Description

A kind of medical adhesive glue and its preparation method and application

technical field

The invention belongs to the technical field of biomedical materials, and in particular relates to a medical adhesive and its preparation method and application.

Background technique

Surgical sutures or skin staplers are commonly used in clinical medicine to connect ruptured tissues to restore the normal structure and function of the body. The use of traditional staplers is complicated and time-consuming, and the suture material is likely to cause local tissue ischemia due to tight incision suturing, resulting in inflammation of surrounding tissues, nodular hyperplasia, or postoperative scars. With the rapid development of the economy and the promotion of medical and health services, patients' demand for surgical services and the appearance of postoperative wounds continues to increase. In recent years, the research and development and industrialization of biomedical adhesives have developed rapidly. The medical adhesive can quickly solidify to form a film and be tightly inlaid with the wound surface, which can firmly maintain the apposition state of the wound, reduce the bleeding and infection chance of the wound, and have the functions of controlling bleeding, closing the wound and inhibiting scar hyperplasia.

CN103585671A discloses a cyanoacrylate medical adhesive. The cyanoacrylate adhesive includes the following components in mass percentage: cyanoacrylate 80-95%, citric acid ester 2-10%, formaldehyde inhibitor 2-8%, hydroquinone 0.1- 0.5% and sulfur dioxide stabilizer 0.1-1.0%; the preparation method of the cyanoacrylate medical adhesive is: accurately weigh cyanoacrylate and citrate according to the mass ratio and mix them, add formaldehyde inhibitor and p-benzene After the diphenol is fully stirred, a sulfur dioxide stabilizer is added to prepare the cyanoacrylate medical glue. Although the adhesive prepared by this technical scheme has good bonding strength, its biocompatibility is poor.

CN111876104A discloses a medical adhesive and its preparation process. The medical adhesive includes the following components in parts by weight: 56 parts of α-cyanoacrylate, 0.1 part of sulfur dioxide, 20 parts of water-based polyurethane, 0.5 part of aloe extract, 1 part of polysaccharide compound, aminated carboxymethyl 0.2 parts of chitosan, 1 part of sodium citrate, 1 part of rosin, 0.2 parts of hydroquinone, 1 part of polyethylene glycol, 20 parts of deionized water, catalyst, dehydrating agent and plasticizer. In this technical solution, the components for preparing the medical adhesive are relatively complicated, the process steps for preparing the adhesive are cumbersome, and the prepared adhesive has poor mechanical strength.

With the development of science and technology, viscous hydrogels that feel similar to biological soft tissues represent an innovative class of biomedical sealants. Because of their ability to promote wound healing and tissue regeneration, they have been widely developed in both basic research and clinical applications. For example, CN110484184A discloses a hydrogel adhesive and its preparation method and application. The hydrogel adhesive includes A component and B component, the molar ratio of the hydroxyl amino group in A component to the aldehyde group in B component is 1:1; The buffer solution of ethylene glycol block polymer; B component is the buffer solution containing four-arm polyethylene glycol, gelatin and polydopamine of alkyne end-capping; The preparation method comprises the following steps: (1) the sulfhydryl end-capping The polyethylene glycol block polymer is added to the buffer, and heated under an inert atmosphere until it is completely dissolved to obtain component A; (2) Dissolve dopamine in the buffer, adjust the pH to 11.0, and stir at room temperature for 2-3 hours to make Dopamine is polymerized to form polydopamine, adjust the pH to 7-8, add alkyne-terminated four-arm polyethylene glycol and gelatin, and stir evenly at room temperature to obtain component B; The molar ratio with the aldehyde group is 1:1, and the hydrogel adhesive is obtained. In this technical solution, the steps for preparing the mercapto-terminated polyethylene glycol block polymer are relatively complicated, which makes the method for preparing the hydrogel adhesive complicated and cumbersome, and is not suitable for industrial production.

In order to improve the wound repairing ability of the adhesive to the tissue and the later healing, the ideal medical adhesive must be able to achieve a close fit with the soft tissue. Therefore, how to provide a medical adhesive with both mechanical strength and bending deformation and a simple preparation process has become a technical problem to be solved urgently.

Contents of the invention

Aiming at the deficiencies of the prior art, the object of the present invention is to provide a medical adhesive and its preparation method and application. In the present invention, through the design of the raw material components of the medical adhesive adhesive, the prepared medical adhesive adhesive has higher adhesion strength, better fit, good biocompatibility and degradability, and can realize Wound sealing, etc.

For reaching this purpose, the present invention adopts following technical scheme:

In the first aspect, the present invention provides a medical adhesive, the raw materials for the preparation of the medical adhesive include the following components in parts by weight: 6-50 parts of acrylate polyethylene glycol, 0.2-35 parts of acrylic compound 0.001-1 part of cross-linking agent and 0.1-3 parts of alkaline buffer.

In the present invention, through the design of the raw material components of the medical adhesive glue, and further through the reaction between the acrylate polyethylene glycol, the acrylic compound and the crosslinking agent, a medical adhesive glue with a cross-network structure is prepared. , so that the prepared medical adhesive has high adhesive strength and mechanical strength, and has good biocompatibility and biodegradability.

In the present invention, the weight parts of the acrylate polyethylene glycol can be 6 parts, 10 parts, 15 parts, 20 parts, 25 parts, 30 parts, 35 parts, 40 parts, 45 parts or 50 parts.

The parts by weight of the acrylic compound can be 0.2 parts, 1 part, 2 parts, 5 parts, 8 parts, 10 parts, 15 parts, 17 parts, 20 parts, 22 parts, 25 parts, 27 parts, 30 parts, 33 or 35 etc.

The parts by weight of the crosslinking agent can be 0.001 part, 0.005 part, 0.01 part, 0.02 part, 0.05 part, 0.1 part, 0.2 part, 0.3 part, 0.4 part, 0.5 part, 0.6 part, 0.7 part, 0.8 part, 0.9 part or 1 part etc.

The parts by weight of the alkaline buffering agent can be 0.1 part, 0.2 part, 0.5 part, 0.7 part, 1 part, 1.2 part, 1.5 part, 1.8 part, 2 parts, 2.3 parts, 2.5 parts, 2.7 parts or 3 parts Wait.

The following are preferred technical solutions of the present invention, but not as limitations on the technical solutions provided by the present invention. Through the following preferred technical solutions, the purpose and beneficial effects of the present invention can be better realized.

As a preferred technical solution of the present invention, the acrylate polyethylene glycol is selected from polyethylene glycol methyl ether methacrylate, polyethylene glycol methacrylate, polyethylene glycol diacrylate, polyethylene glycol Any one or a combination of at least two of alcohol dimethacrylate or methoxy polyethylene glycol acrylate.

Preferably, the weight-average molecular weight of the acrylate polyethylene glycol is 300-2000, for example, 300, 400, 600, 800, 1000, 1200, 1400, 1600, 1800 or 2000.

Preferably, the acrylic compound is selected from any one or at least two compounds of acrylic acid, methacrylic acid or 2-ethylacrylic acid.

As a preferred technical solution of the present invention, the crosslinking agent is selected from polyethylene glycol diacrylate, N,N-methylenebisacrylamide, polyethylene glycol dimethacrylate or ethylene glycol dimethyl Any one or a combination of at least two of acrylates.

Preferably, the cross-linking agent has a weight average molecular weight of 300-2000, for example, 300, 400, 600, 800, 1000, 1200, 1400, 1600, 1800 or 2000.

Preferably, the alkaline buffer is selected from any one or a combination of at least two of sodium hydroxide, sodium bicarbonate or disodium hydrogen phosphate.

Preferably, the alkaline buffer is an alkaline buffer solution.

Preferably, the mass percentage of alkaline buffer in the alkaline buffer solution is 5-30%, for example, it can be 5%, 7%, 10%, 12%, 15%, 18%, 22%, 25%, 27%, or 30%, etc.

As a preferred technical solution of the present invention, the raw materials for the preparation of the medical adhesive also include 1-15 parts of thickener, such as 1 part, 2 parts, 3 parts, 4 parts, 5 parts, 6 parts, 7 parts parts, 8 parts, 9 parts, 10 parts, 11 parts, 12 parts, 13 parts, 14 parts or 15 parts etc.

Preferably, the thickener is selected from gelatin and/or sodium alginate.

As a preferred technical solution of the present invention, the raw materials for the preparation of the medical adhesive also include 0.001-1 part of initiator, such as 0.001 part, 0.005 part, 0.01 part, 0.02 part, 0.05 part, 0.07 part, 0.1 part , 0.2, 0.3, 0.4, 0.5, 0.6, 0.7, 0.8, 0.9 or 1 etc.

Preferably, the initiator is selected from thermal initiators or photoinitiators.

Preferably, the thermal initiator is selected from ammonium persulfate and/or potassium persulfate.

Preferably, the photoinitiator is selected from 2-hydroxyl-4-(2-hydroxyethoxy)-2-methylpropiophenone, 2-benzyl-2-dimethylamino-1-(4-methanol Any one or a combination of at least two of phenyline phenyl) butanone, azobisisobutimidazoline hydrochloride or azobisisobutimidazoline hydrochloride.

Preferably, the raw materials for the preparation of the medical adhesive also include 50-99 parts of water, such as 50 parts, 55 parts, 60 parts, 65 parts, 70 parts, 75 parts, 80 parts, 85 parts, 90 parts , 95 or 99 copies, etc.

In a second aspect, the present invention provides a method for preparing a medical adhesive as described in the first aspect, comprising the steps of:

(1) Mix acrylate polyethylene glycol, acrylic compound, crosslinking agent and water to obtain mixed solution A;

An optional thickener is mixed with water to obtain a mixed solution B;

(2) After mixing the mixed solution A, mixed solution B, alkaline buffer and initiator obtained in the step (1), carry out a crosslinking reaction to obtain the medical adhesive.

It should be noted that the use of the alkaline buffer can adjust the pH of the mixed solution described in step (2) to 6-7, which can be in direct contact with the skin, and in the present invention, it can also be used in step (2). ) after mixing, the mixture is transferred to a mold with a specific shape for cross-linking reaction, and a medical adhesive with a specific shape is prepared. In addition, in the embodiment, in order to clearly characterize the bonding performance of the adhesive, methylene blue (0.01-0.1 part) can be added to the mixed solution A for dyeing, so that the prepared adhesive appears blue.

As a preferred technical solution of the present invention, the mass percentage of the mixed solution A is 6-50%, such as 6%, 10%, 15%, 20%, 25%, 30%, 35%, 40% , 45% or 50% etc.

Preferably, the mass percentage of the mixed solution B is 5-30%, such as 5%, 7%, 10%, 12%, 15%, 18%, 20%, 22%, 25%, 27% % or 30% etc.

As a preferred technical solution of the present invention, the crosslinking reaction in step (2) is selected from thermal crosslinking reaction or photocrosslinking reaction.

It should be noted that if the initiator added in step (2) is a thermal initiator, then step (2) carries out thermal crosslinking reaction; if the crosslinking agent added in step (2) is a photoinitiator, then step ( 2) Carry out photocrosslinking reaction.

Preferably, the temperature of the thermal crosslinking reaction is 60-80°C, such as 60°C, 62°C, 64°C, 66°C, 68°C, 70°C, 72°C, 74°C, 76°C, 78°C or 80°C etc.

Preferably, the photocrosslinking reaction is carried out under ultraviolet light.

Preferably, the time of the cross-linking reaction is 0.5-60min, such as 0.5min, 1min, 2min, 5min, 7min, 10min, 12min, 15min, 18min, 20min, 23min, 25min, 27min, 30min, 40min, 50min or 60min etc.

Preferably, after the mixing in step (2), a post-processing step is also included.

Preferably, the post-treatment method is ultrasonic deoxygenation.

In the present invention, by performing the ultrasonic deoxygenation operation after the mixing described in step (2), the oxygen in the mixture can be removed to avoid the influence of the presence of oxygen on the subsequent crosslinking reaction. If the deoxygenation operation is not performed, the final prepared medical The gelling effect of the adhesive glue is poor, and even cannot be gelled.

As a preferred technical solution of the present invention, the preparation method specifically includes the following steps:

(1) uniformly mixing acrylate polyethylene glycol, acrylic compound, crosslinking agent and water to obtain a mixed solution A with a mass percentage of 6-50%;

Mix the optional thickener and water evenly to obtain B with a mass percent content of 5-30% mixed solution;

(2) Mix the mixed solution A, mixed solution B, buffer solution and initiator obtained in the step (1) uniformly, and carry out cross-linking after ultrasonic deoxygenation to obtain the medical adhesive.

In a third aspect, the present invention provides an application of the medical adhesive glue as described in the first aspect, the application includes that the medical adhesive glue is used as a wound hemostatic material, visceral and soft tissue wound sealing and plugging material, Repair materials for fibrous annulus rupture or drug carrier materials for tissue engineering.

Compared with the prior art, the present invention has the following beneficial effects:

In the present invention, through the design of the raw material components of the medical adhesive glue, the prepared medical adhesive glue not only has relatively high adhesion strength, but can instantly adhere to tissues, and its adhesion strength is 40-88N/m, and has better Excellent bending fit, can be closely attached to tissue joints, and has biocompatibility and biodegradability, has no toxic and side effects on organisms, and is suitable for wound hemostasis, visceral and soft tissue wound sealing and plugging, and fibrous annulus rupture Drug carrier for repair or tissue engineering.

Description of drawings

Fig. 1 is the physical figure that the medical adhesive glue that the embodiment 1 of the present invention makes carries out the adhesion fit test;

Fig. 2 is the physical picture of the flexible bending deformation test of the medical adhesive glue prepared in Example 4 of the present invention;

Fig. 3 is an actual picture of the adhesion test of the medical adhesive prepared in Example 5 of the present invention.

Detailed ways

The technical solutions of the present invention will be further described below in conjunction with the accompanying drawings and through specific implementation methods. It should be clear to those skilled in the art that the examples are only for helping to understand the present invention, and should not be regarded as specific limitations on the present invention.

Part raw material component source is as follows in following embodiment and comparative example:

Polyethylene glycol methyl ether methacrylate: Sigma-Aldrich;

Polyethylene glycol methacrylate: Hunan Huateng Pharmaceutical Co., Ltd.;

Polyethylene glycol diacrylate: Sigma-Aldrich;

Methoxy polyethylene glycol acrylate: Shanghai Sig Biotechnology Co., Ltd.;

Polyethylene glycol dimethacrylate: Sigma-Aldrich;

Gelatin: Sigma-Aldrich;

Sodium alginate: Shanghai McLean Biochemical Technology Co., Ltd.

Example 1

This embodiment provides a medical adhesive and its preparation method. The raw materials for its preparation include the following components in parts by weight: 29.8 parts of polyethylene glycol methyl ether methacrylate, 0.2 parts of acrylic acid, polyethylene glycol diacrylic acid 0.01 part of ester, 0.1 part of sodium hydroxide solution, 5 parts of gelatin, 0.05 part of ammonium persulfate, 0.01 part of methylene blue and 64 parts of water;

The mass percentage of the sodium hydroxide solution is 20%.

The preparation method of above-mentioned medical adhesive glue is as follows:

(1) Mix polyethylene glycol methyl ether methacrylate, acrylic acid, polyethylene glycol diacrylate, methylene blue and water evenly to obtain a mixed solution A with a mass percentage of 30%;

Mix the gelatin and water evenly to obtain a mixed solution B with a mass percentage of 5%;

(2) After mixing the mixed solution A, mixed solution B, sodium hydroxide solution and ammonium persulfate obtained in step (1) uniformly, after deoxygenation by ultrasonic waves, heat to 70°C for cross-linking reaction for 25 minutes to obtain the medical Adhesive glue.

Carry out the fit test on the medical adhesive glue prepared in this example, as shown in Figure 1, cut the medical adhesive glue provided in this example into a long strip of 8cm×1.5cm, and attach it to the On the steel ruler with a 120° angle, it can be seen from Figure 1 that the medical adhesive can be closely adhered to the steel ruler, indicating that its fit is good.

Example 2

This example provides a medical adhesive and its preparation method. The preparation raw materials include the following components in parts by weight: 6 parts of polyethylene glycol methacrylate, 35 parts of methacrylic acid, N,N-methylene 0.1 part of bisacrylamide, 0.1 part of alkaline buffer solution, 5 parts of sodium alginate, 0.01 part of 2-hydroxy-4-(2-hydroxyethoxy)-2-methylpropiophenone and 52 parts of water;

The alkaline buffer is composed of sodium hydroxide and disodium hydrogen phosphate in a mass ratio of 3:1, and the mass percentage of the alkaline buffer solution is 20%.

The preparation method of above-mentioned medical adhesive glue is as follows:

(1) Mix polyethylene glycol methacrylate, methacrylic acid, N,N-methylenebisacrylamide and water evenly to obtain a mixed solution A with a mass percentage of 45%;

Mix sodium alginate and water evenly to obtain a mixed solution B with a mass percentage of 10%;

(2) After the mixed solution A, mixed solution B, alkaline buffer solution and 2-hydroxyl-4-(2-hydroxyethoxy)-2-methyl propiophenone obtained in step (1) are mixed uniformly, After ultrasonic deoxygenation, under the irradiation of an ultraviolet mercury lamp with a power of 2000W, photocrosslinking was carried out for 1 min to obtain the medical adhesive.

Example 3

This embodiment provides a kind of medical adhesive glue and its preparation method, and its preparation raw material comprises the following components in parts by weight: 50 parts of methoxypolyethylene glycol acrylate, 5 parts of acrylic acid, polyethylene glycol dimethyl 0.01 part of acrylate, 3 parts of sodium bicarbonate solution, 3 parts of gelatin, 0.01 part of potassium persulfate and 42 parts of water;

The mass percentage of the sodium bicarbonate solution is 30%.

The preparation method of above-mentioned medical adhesive glue is as follows:

(1) Mix methoxypolyethylene glycol acrylate, acrylic acid, polyethylene glycol dimethacrylate and water evenly to obtain a mixed solution A with a mass percentage of 55%;

Mix the gelatin and water evenly to obtain a mixed solution B with a mass percentage of 15%;

(2) After mixing the mixed solution A, mixed solution B, sodium bicarbonate solution and potassium persulfate obtained in step (1) evenly, after deoxygenation by ultrasonic waves, heat to 65°C for 30 minutes for cross-linking reaction to obtain the medical Adhesive glue.

Example 4

This embodiment provides a medical adhesive and its preparation method. The raw materials for its preparation include the following components in parts by weight: 20 parts of methoxypolyethylene glycol acrylate, 10 parts of 2-ethylacrylic acid, N,N - 0.01 part of methylenebisacrylamide, 1 part of alkaline buffer solution, 15 parts of sodium alginate, 0.1 part of ammonium persulfate and 55 parts of water;

The alkaline buffer is composed of disodium hydrogen phosphate and sodium hydroxide with a mass ratio of 1:2, and the mass percentage of the alkaline buffer in the alkaline buffer solution is 15%.

The preparation method of above-mentioned medical adhesive glue is as follows:

(1) Mix methoxypolyethylene glycol acrylate, 2-ethylacrylic acid, N,N-methylenebisacrylamide and water evenly to obtain a mixed solution A with a mass percentage of 30%;

Mix sodium alginate and water evenly to obtain a mixed solution B with a mass percentage of 15%;

(2) After mixing the mixed solution A, mixed solution B, alkaline buffer solution and ammonium persulfate obtained in step (1) uniformly, after ultrasonic deoxygenation, heat to 70° C. for 30 minutes for cross-linking reaction to obtain the described Medical adhesive.

The medical adhesive prepared in this embodiment was tested for flexibility and bendability. As shown in Figure 2, the medical adhesive provided in this embodiment can be bent 360° to form a ring and maintain this stable shape, indicating that the medical adhesive has Excellent flexible bending deformation performance.

Example 5

This embodiment provides a medical adhesive and its preparation method. The raw materials for its preparation include the following components in parts by weight: 10 parts of polyethylene glycol methacrylate, 15 parts of acrylic acid, ethylene glycol dimethacrylate 0.05 parts, 0.3 parts of sodium hydroxide solution, 8 parts of gelatin, 0.05 parts of 2-benzyl-2-dimethylamino-1-(4-morpholine phenyl) butanone, 0.1 parts of methylene blue and 68 parts of water;

The mass percentage of the sodium hydroxide solution is 25%.

The preparation method of above-mentioned medical adhesive glue is as follows:

(1) uniformly mixing polyethylene glycol methacrylate, acrylic acid, ethylene glycol dimethacrylate and water to obtain a mixed solution with a mass percentage of 25%;

(2) After mixing the mixed solution obtained in step (1), sodium hydroxide solution and 2-benzyl-2-dimethylamino-1-(4-morpholine phenyl) butanone evenly, deoxygenate by ultrasonic Afterwards, under the irradiation of an ultraviolet mercury lamp with a power of 2000W, photocrosslinking was carried out for 2 minutes to obtain the medical adhesive.

Adhesion and fit test was carried out on the medical adhesive prepared in this example, as shown in Figure 3, the medical adhesive provided in this example can adhere tightly to the joints of the hand and follow the bending of the joints Adhesive fit is present, indicating that the medical adhesive has good adhesion and fit performance.

Example 6

This embodiment provides a medical adhesive and its preparation method. The only difference from Embodiment 1 is that the weight part of polyethylene glycol diacrylate is 0.001 part; other conditions are the same as Embodiment 1.

Example 7

This embodiment provides a medical adhesive and its preparation method. The only difference from Embodiment 1 is that the weight part of polyethylene glycol diacrylate is 1 part; other conditions are the same as Embodiment 1.

Comparative example 1

This comparative example provides a medical adhesive and its preparation method. The only difference from Example 1 is that the weight part of polyethylene glycol diacrylate is 1.2 parts; other conditions are the same as Example 1.

Comparative example 2

This comparative example provides a kind of medical adhesive glue and its preparation method. The difference from Example 1 is that the raw material components of the medical adhesive glue do not contain polyethylene glycol methyl ether methacrylate, acrylic acid The parts by weight are 30 parts; Other conditions are identical with embodiment 1.

Comparative example 3

This comparative example provides a kind of medical adhesive glue and preparation method thereof, and the difference with embodiment 1 is only, the raw material component of described medical adhesive glue does not contain acrylic acid, polyethylene glycol methyl ether methacrylate Parts by weight are 30 parts; Other conditions are the same as in Example 1.

The performance of the medical adhesive provided by the above-mentioned embodiment and comparative example is tested, and the test standard is as follows:

Adhesion Strength: Tested according to the T-Peel Test (ASTM D903) Adhesion Test Method for Testing the Peeling of Flexible Adhesives from Harder Substrates.

The test result of the medical adhesive glue performance that above-mentioned embodiment and comparative example provide are as shown in table 1:

Table 1

Example 1 Example 2 Example 3 Example 4 Example 5 Adhesion strength (N/m) 60 42 88 54 40 Example 6 Example 7 Comparative example 1 Comparative example 2 Comparative example 3 Adhesion strength (N/m) 48 40 30 28 35

It can be seen from Table 1 and Figures 1-3 that the medical adhesive prepared by the present invention has a high adhesive strength and can instantly adhere to tissues through the design of the raw material components of the medical adhesive. The adhesive strength is 40-88N/m, and has good bending fit, can closely fit tissue joints, has biocompatibility and biodegradability, has no toxic and side effects on organisms, and is suitable for wound hemostasis, internal organs and soft tissues Wound sealing and plugging, repair of annulus fibrosus rupture or drug carrier for tissue engineering.

Compared with Example 1, if the content of cross-linking agent in the preparation raw material of medical adhesive glue is too large (comparative example 1), then the adhesive strength of the medical adhesive glue prepared is as low as 30N/m; If the raw materials for the preparation of the adhesive do not contain acrylate-based polyethylene glycol (comparative example 2) or acrylic compounds (comparative example 3), the prepared adhesive strength is also low. It can be seen that the present application can prepare medical adhesives with higher adhesive strength by designing the raw material components and contents for the preparation of medical adhesives.

The applicant declares that the present invention illustrates the detailed process flow of the present invention through the above-mentioned examples, but the present invention is not limited to the above-mentioned detailed process flow, that is, it does not mean that the present invention must rely on the above-mentioned detailed process flow to be implemented. Those skilled in the art should understand that any improvement of the present invention, the equivalent replacement of each raw material of the product of the present invention, the addition of auxiliary components, the selection of specific methods, etc., all fall within the scope of protection and disclosure of the present invention.

Claims (10)

1. A medical adhesive, characterized in that, the raw materials for preparing the medical adhesive include the following components in parts by weight: 6-50 parts of acrylate polyethylene glycol, 0.2-35 parts of acrylic compound , 0.001-1 parts of cross-linking agent and 0.1-3 parts of alkaline buffer. 2. The medical adhesive according to claim 1, wherein the acrylic polyethylene glycol is selected from polyethylene glycol methyl ether methacrylate, polyethylene glycol methacrylate, polyethylene glycol Any one or a combination of at least two of ethylene glycol diacrylate, polyethylene glycol dimethacrylate or methoxypolyethylene glycol acrylate; Preferably, the weight average molecular weight of the acrylate polyethylene glycol is 300-2000; Preferably, the acrylic compound is selected from any one or at least two compounds of acrylic acid, methacrylic acid or 2-ethylacrylic acid. 3. The medical adhesive according to claim 1 or 2, wherein the crosslinking agent is selected from polyethylene glycol diacrylate, N, N-methylenebisacrylamide, polyethylene glycol Any one or a combination of dimethacrylate or ethylene glycol dimethacrylate; Preferably, the weight average molecular weight of the crosslinking agent is 300-2000; Preferably, the alkaline buffer is selected from any one or a combination of at least two of sodium hydroxide, sodium bicarbonate or disodium hydrogen phosphate; Preferably, the alkaline buffer is an alkaline buffer solution; Preferably, the mass percent content of the alkaline buffer in the alkaline buffer solution is 5-30%. 4. The medical adhesive according to any one of claims 1-3, characterized in that, the raw materials for preparing the medical adhesive also include 1-15 parts of thickener; Preferably, the thickener is selected from gelatin and/or sodium alginate. 5. The medical adhesive according to any one of claims 1-4, characterized in that 0.001-1 part of initiator is also included in the raw materials for preparing the medical adhesive; Preferably, the initiator is selected from a thermal initiator or a photoinitiator; Preferably, the thermal initiator is selected from ammonium persulfate and/or potassium persulfate; Preferably, the photoinitiator is selected from 2-hydroxyl-4-(2-hydroxyethoxy)-2-methylpropiophenone, 2-benzyl-2-dimethylamino-1-(4-methanol Any one or a combination of at least two of phenyline phenyl) butanone, azobisisobutyrazine hydrochloride or azobisisobutylimidazoline hydrochloride; Preferably, the raw materials for the preparation of the medical adhesive also include 50-99 parts of water. 6. a preparation method of the medical adhesive as claimed in any one of claims 1-5, is characterized in that, described preparation method comprises the steps: (1) Mix acrylate polyethylene glycol, acrylic compound, crosslinking agent and water to obtain mixed solution A; An optional thickener is mixed with water to obtain a mixed solution B; (2) After mixing the mixed solution A, mixed solution B, alkaline buffer and initiator obtained in the step (1), carry out a crosslinking reaction to obtain the medical adhesive. 7. The preparation method according to claim 6, characterized in that, the mass percentage of the mixed solution A is 6-50%; Preferably, the mass percentage of the mixed solution B is 5-30%. 8. The preparation method according to claim 6 or 7, characterized in that, the crosslinking reaction in step (2) is selected from thermal crosslinking reaction or photocrosslinking reaction; Preferably, the temperature of the thermal crosslinking reaction is 60-80°C; Preferably, the photocrosslinking reaction is a crosslinking reaction under ultraviolet light; Preferably, the time of the crosslinking reaction is 0.5-60min; Preferably, after the mixing described in step (2), the step of post-processing is also included; Preferably, the post-treatment method is ultrasonic deoxygenation. 9. according to the preparation method described in any one of claim 6-8, it is characterized in that, described preparation method specifically comprises the following steps: (1) uniformly mixing acrylate polyethylene glycol, acrylic compound, crosslinking agent and water to obtain a mixed solution A with a mass percentage of 6-50%; Mix the optional thickener and water evenly to obtain a mixed solution B with a mass percentage of 5-30%; (2) Mix the mixed solution A, mixed solution B, buffer solution and initiator obtained in the step (1) uniformly, and carry out cross-linking reaction after ultrasonic deoxygenation to obtain the medical adhesive. 10. a kind of application of medical adhesive glue as described in any one of claim 1-5, described application comprises that described medical adhesive glue is used as wound surface hemostatic material, viscera and soft tissue wound sealing and plugging material, Repair materials for fibrous annulus rupture or drug carrier materials for tissue engineering.

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