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CN115211557A - Hangover-alleviating and liver-protecting composition and preparation method of tablet containing same - Google Patents

Hangover-alleviating and liver-protecting composition and preparation method of tablet containing same Download PDF

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Publication number
CN115211557A
CN115211557A CN202210869308.4A CN202210869308A CN115211557A CN 115211557 A CN115211557 A CN 115211557A CN 202210869308 A CN202210869308 A CN 202210869308A CN 115211557 A CN115211557 A CN 115211557A
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liver
protecting
powder
relieving alcoholism
composition
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刘杰
王志伟
胡坤鹏
王誉臻
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Shangshi Wuxi Food Technology Development Co ltd
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Shangshi Wuxi Food Technology Development Co ltd
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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L13/00—Meat products; Meat meal; Preparation or treatment thereof
    • A23L13/20—Meat products; Meat meal; Preparation or treatment thereof from offal, e.g. rinds, skins, marrow, tripes, feet, ears or snouts
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L13/00—Meat products; Meat meal; Preparation or treatment thereof
    • A23L13/50—Poultry products, e.g. poultry sausages
    • A23L13/52—Comminuted, emulsified or processed products; Pastes; Reformed or compressed products from poultry meat
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L19/00—Products from fruits or vegetables; Preparation or treatment thereof
    • A23L19/10—Products from fruits or vegetables; Preparation or treatment thereof of tuberous or like starch containing root crops
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L27/00—Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
    • A23L27/30—Artificial sweetening agents
    • A23L27/33—Artificial sweetening agents containing sugars or derivatives
    • A23L27/34—Sugar alcohols
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
    • A23P10/00—Shaping or working of foodstuffs characterised by the products
    • A23P10/20—Agglomerating; Granulating; Tabletting
    • A23P10/28—Tabletting; Making food bars by compression of a dry powdered mixture
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/57—Birds; Materials from birds, e.g. eggs, feathers, egg white, egg yolk or endothelium corneum gigeriae galli
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/488—Pueraria (kudzu)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

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Abstract

The invention provides a composition for relieving alcoholism and protecting liver, which has the health care functions of calming liver and benefiting gallbladder, clearing away heat and toxic materials, and improving eyesight and sobering up, has good effects of relieving alcoholism and protecting liver, low production cost and high economic applicability, and comprises 30-40 parts by weight of unitary wood powder and auxiliary materials, wherein the auxiliary materials comprise kudzuvine root powder and sweetening agents; the invention also provides a preparation method of the tablet for relieving alcoholism and protecting liver, which is characterized in that the tablet for relieving alcoholism and protecting liver is prepared by mixing the unitary wood powder and the auxiliary materials, tabletting and coating.

Description

Hangover-alleviating and liver-protecting composition and preparation method of tablet containing same
Technical Field
The invention belongs to the technical field of health-care functional foods, particularly relates to the technical field of anti-alcoholism and liver-protecting products, and particularly relates to an anti-alcoholism and liver-protecting composition and a preparation method of a tablet containing the same.
Background
Because alcohol can generate a plurality of substances which are not beneficial to human health in the metabolic process of a human body, such as generation of acetaldehyde with carcinogenic effect, free radicals capable of causing lipid, DNA and protein peroxidation and the like, although moderate drinking can activate blood circulation, remove obstruction in channels, dispel cold, eliminate fatigue and stress and the like, and is beneficial to human health, excessive drinking or alcoholism is one of main causes of death in the global scope, for example, acute large-amount drinking can cause adverse symptoms such as nausea, vomiting, hypomnesis, inattention and the like, and long-term drinking can cause mental disorder, alcoholic fatty liver, alcoholic hepatitis, liver cirrhosis and other diseases, so in order to reduce the occurrence of drunkenness events, reduce loss caused by drunkenness and ensure physical and mental health and social safety of drinkers, it is necessary to develop foods, medicines and other liver-protecting and alcohol-dispelling products with alcohol dispelling effects.
The existing sobering-up and liver-protecting products are mostly prepared from plant Chinese medicinal materials such as kudzuvine root, hovenia dulcis thunb or turmeric, the sobering-up and liver-protecting effects are general, the pharmacological effects of the sobering-up and liver-protecting products are dose-dependent, the natural bear gall powder of animal Chinese medicinal materials is taken as the main raw material, although the sobering-up and liver-protecting effects of the sobering-up and liver-protecting products are better, the wild resources are limited, the production cost is higher, the batch production and the application are difficult, the economic applicability is poor, and in order to protect wild animals and realize sustainable development, the natural bear gall powder is not suitable to be used in a large amount.
Disclosure of Invention
Aiming at the defects of common effects, high production cost and poor economic applicability of the existing product for relieving alcoholism and protecting liver, the invention provides a composition for relieving alcoholism and protecting liver, which has good effects on relieving alcoholism and protecting liver, low production cost and high economic applicability, and the invention also provides a preparation method of the composition for relieving alcoholism and protecting liver.
The invention adopts the following technical scheme: the method is characterized in that: the edible fungus powder comprises 30-40 parts by weight of unitary wood powder and auxiliary materials, wherein the auxiliary materials comprise radix puerariae powder and a sweetening agent.
It is further characterized in that:
the kudzu root powder is 20-10 parts by weight;
the sweetening agent accounts for 50 parts by weight;
the sweetener is erythritol.
A preparation method of a tablet for relieving alcoholism and protecting liver is characterized by comprising the following steps: and mixing the unitary wood powder and the auxiliary materials, tabletting and coating to obtain the hangover-alleviating and liver-protecting tablet.
The invention has the beneficial effects that: the unitary wood powder is prepared by taking poultry liver gall as a raw material, contains protein, vitamins, taurochenodeoxycholic acid and tauroursodeoxycholic acid, has similar chemical components with bear gall powder, and has the effect of dispelling the effects of the bear gall powder.
Drawings
FIG. 1 is HPLC chromatogram of natural fel Ursi powder.
Fig. 2 is HPLC chromatogram of unitary wood powder.
Detailed Description
Example 1
According to the weight parts, 30 parts of unitary wood powder, 20 parts of kudzu root powder and 50 parts of sweetener, wherein the sweetener is erythritol; mixing fructus Caricae powder, radix Puerariae powder and sweetener, tabletting, and coating to obtain the tablet for relieving hangover and protecting liver.
Example 2
According to the weight parts, 35 parts of unitary wood powder, 15 parts of kudzu root powder and 50 parts of sweetener, wherein the sweetener is erythritol; mixing the fructus Caricae powder, radix Puerariae powder 2 and sweetener, tabletting, and coating to obtain the tablet for relieving hangover and protecting liver.
Example 3
40 parts of unitary wood powder, 10 parts of kudzu root powder and 50 parts of sweetening agent by weight, wherein the sweetening agent is erythritol; mixing the fructus Caricae powder, radix Puerariae powder 2 and sweetener, tabletting, and coating to obtain the tablet for relieving hangover and protecting liver.
The unitary wood powder is prepared by taking the liver and gall of birds as raw materials, is mainly used as a seasoning at present, is produced by Shandong white feather food Co., ltd, is mainly prepared by the liver and gall of chickens, and is golden yellow crystal-shaped particles; the unitary wood powder contains protein, vitamins, taurochenodeoxycholic acid and tauroursodeoxycholic acid, and is similar to the chemical components of bear gall powder, and modern medical research proves that the bear gall powder can inhibit the absorption of ethanol, accelerate the oxidation of ethanol in vivo and is beneficial to metabolism, so that the unitary wood powder has the function of dispelling the effects of alcohol, and the bear gall powder can reduce the damage of liver cells and relieve the toxic effect of bile acid, so that the unitary wood powder has the effect of protecting the liver.
As shown in fig. 1, fig. 2 and table one, the unitary wood powder has chromatographic peaks similar to natural bear gall powder with retention time of tauroursodeoxycholic acid (TUDCA) and tauroursodeoxycholic acid (TCDCA) determined by HPLC chromatography of banze bio-pharmaceuticals, that is, the unitary wood powder has effective components of tauroursodeoxycholic acid and tauroursodeoxycholic acid for relieving alcoholism and protecting liver equivalent to natural bear gall powder.
Wherein, the chromatograph used for HPLC chromatogram determination is Agilent 1200 and a digital-to-analog converter Agilent 35900E, and the chromatographic Column is water Xbridge R-C18 Column with the inner diameter of 4.6mm, the length of 150.0mm and the particle size of 5 μm; the maximum pressure is 400.0 bar, the maximum temperature is 60.0 ℃, the pH value range is 2.0-9.0, acetonitrile solution is taken as a mobile phase A,0.3 percent formic acid solution is taken as a mobile phase B for gradient elution, and the gradient elution is detected and measured by an evaporative light scattering detector.
The radix Puerariae powder is prepared from radix Puerariae which is dried root of Pueraria lobata Ohwi of Pueraria of Leguminosae, and modern medical research proves that radix Puerariae is not only nutritious, but also contains isoflavone effective components such as daidzin and puerarin, and has effects of protecting liver and relieving alcoholic intoxication.
Erythritol is a low-calorie sweetener, is about one tenth of the calorific value of sucrose, has a cool feeling, has a relative sweetness of 0.65, can be used as a diluent of a high-sweetness sweetener, is suitable for foods needing sucrose taste, does not cause dental caries, is not degraded by enzyme, does not participate in sugar metabolism and blood sugar change, can be discharged from blood to urine only through kidney (easily absorbed by small intestine), and is beneficial to diabetics; erythritol is not fermented in colon, and gastrointestinal discomfort can be avoided.
Table one: HPLC chromatographic peak value of unitary wood powder and bear gall powder
Figure 532467DEST_PATH_IMAGE001
Therefore, the anti-alcoholism and liver-protecting composition provided by the invention takes the animal anti-alcoholism and liver-protecting active ingredient common vegetable seed powder as a main component, and the plant anti-alcoholism and liver-protecting active ingredient kudzu root powder and the low-calorie sweetening agent erythritol as auxiliary components, so that the anti-alcoholism and liver-protecting composition is good in anti-alcoholism and liver-protecting effect, low in production cost, high in economic applicability, and suitable for special crowds, such as diabetic patients and gastrointestinal tract discomfort people.
The unitary wood powder and the auxiliary materials are mixed, and then tabletting and coating are carried out to prepare the hangover-alleviating and liver-protecting tabletting which is convenient to package, carry and eat, preferably, all components of the hangover-alleviating and liver-protecting composition are fully and uniformly mixed, so that the mutual auxiliary exertion of animal performance of the unitary wood powder and plant hangover-alleviating and liver-protecting effect of the kudzuvine root powder is facilitated, the good taste effect of the sweetening agent is achieved, the preparation of the tabletting preparation is facilitated, and the tabletting quality is improved.
The anti-alcoholism and liver-protection tablets are obtained by mixing, tabletting and coating three anti-alcoholism and liver-protection compositions with different proportions, and the content of active ingredients is shown in the table II, wherein the content of taurochenodeoxycholic acid is more than 60mg/g, and the content of tauroursodeoxycholic acid is more than 40 mg/g;
a second table: tauroursodeoxycholic acid and taurochenodeoxycholic acid contents
Figure DEST_PATH_IMAGE002
Animal experiments prove that compared with pure plant pueraria powder serving as a control group and an alcoholic liver model group, the animal unitary wood powder serving as an effective component for relieving or neutralizing the effect of alcohol and protecting the liver, the plant pueraria powder serving as an effective component for relieving or neutralizing the effect of alcohol and protecting the liver and low-calorie sweetener erythritol are used as auxiliary materials, so that the tablet for relieving or neutralizing the effect of alcohol and protecting the liver has better effects of calming the liver, benefiting gallbladder, clearing away heat and toxic materials and improving eyesight and relieving or neutralizing the effect of alcohol.
1. Experimental Material
1.1 Experimental materials
Examples 1, 2 and 3 of the anti-hangover and hepatoprotective tablet; kudzu root powder; a 52 ° red star Erguotou manufactured by Beijing Red Star GmbH; an ethanol content test kit produced by Heifeier Biotechnology Ltd; nanjing creates an Alcohol Dehydrogenase (ADH) activity detection kit and an acetaldehyde dehydrogenase (ALDH) activity detection kit of a bioengineering institute.
1.2 Laboratory animal
Mice, SPF-grade Kunming, weight 20-25 g/mouse.
2. Experimental methods
2.1 Drunkenness preliminary experiment
The method comprises the following steps of randomly dividing 30 mice into three groups, wherein each group of male and female is 5, the three groups are adaptively raised for one week, after fasting for 12 hours, respectively performing intragastric administration of 0.12mL/10g, 0.15mL/10g and 0.18mL/10g on 52-degree Erguotou, and after the mice are drunk, turning over the normal reflex disappearance time till normal activity is recovered to be sobering time, wherein the results are shown in the table III, wherein the sobering time is not calculated because 3 mice die after the 0.18mL/10g of alcoholism is performed, and the limit alcoholism amount of the mice in the alcohol-relieving and liver-protecting experiment is determined to be 0.15mL/10g, namely the weight of the mice per 10g of intragastric administration of 0.15mL of 52-degree Hongxing Erguo.
A third table: results of drunkenness experiments
Figure 14656DEST_PATH_IMAGE003
2.2 Experiment for relieving or neutralizing the effect of alcohol and protecting liver
50 mice were randomly divided into five groups of 10 mice each, and each group had 5 mice each, namely, an alcoholic liver model control group, a pueraria root powder control group, an example 1 group, an example 2 group and an example 3 group.
Five groups are adaptively raised for one week, wherein the alcoholic liver model control group is not pretreated, the gavage dosage of the pueraria root powder control group, the example 1 group, the example 2 group and the example 3 group is 10mg/10g, after 30min, each group of mice is gavaged with a dose of 0.15mL/10g for two-pan with 52 degrees of Hongxing, the sobering time of each group of mice is observed and recorded, and the results are shown in the table four.
Table four: results of drunkenness experiments
Figure DEST_PATH_IMAGE004
Then blood is taken from abdominal aorta of the mouse, the concentration of ethanol in the serum of the mouse is detected by an ethanol content test box, the liver of the mouse is taken out after the mouse is killed, and the activities of the liver tissue ADH and the ALDH are detected by an ethanol dehydrogenase (ADH) activity detection kit and an acetaldehyde dehydrogenase (ALDH) activity detection kit, and the result is shown in the fifth table.
Table five: experimental results for relieving or neutralizing the effect of alcohol and protecting liver
Figure 591131DEST_PATH_IMAGE005
The fourth table shows that the liver-protecting tabletting can obviously reduce the ethanol concentration in the serum of the mouse in terms of the ethanol concentration of the serum of the drunk mouse and the activities of alcohol metabolizing enzymes ADH and ALDH, and simultaneously, the activities of Alcohol Dehydrogenase (ADH) and acetaldehyde dehydrogenase (ALDH) which are main components of an alcohol dehydrogenase ethanol oxidation system for metabolizing alcohol in the liver are increased, so that the liver-protecting tabletting has good liver-protecting and alcohol-dispelling effects.

Claims (5)

1. The composition for relieving alcoholism and protecting liver is characterized by comprising the following components: the edible fungus powder comprises 30-40 parts by weight of unitary wood powder and auxiliary materials, wherein the auxiliary materials comprise radix puerariae powder and a sweetening agent.
2. The composition for relieving alcoholism and protecting liver according to claim 1, wherein: the kudzu root powder is 20-10 parts by weight.
3. The composition for relieving alcoholism and protecting liver according to claim 1, wherein: the sweetening agent accounts for 50 parts by weight.
4. The composition for relieving alcoholism and protecting liver according to claim 1, wherein: the sweetener is erythritol.
5. A process for preparing a tablet comprising the anti-hangover and hepatoprotective composition of any of claims 1 to 4, wherein: and mixing the unitary wood powder and the auxiliary materials, tabletting and coating to obtain the hangover-alleviating and liver-protecting tablet.
CN202210869308.4A 2022-07-23 2022-07-23 Hangover-alleviating and liver-protecting composition and preparation method of tablet containing same Pending CN115211557A (en)

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Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102524781A (en) * 2012-01-05 2012-07-04 北京同仁堂国际药业有限公司 Edible composition with alcoholism alleviation function and preparation method thereof
CN104223107A (en) * 2014-09-26 2014-12-24 洛阳华以生物工程有限公司 Healthcare product with liver-protecting, hangover-alleviating and toxin-eliminating functions
CN105998412A (en) * 2016-06-22 2016-10-12 武汉华士特工业生物技术开发有限公司 Antialcoholism formula and preparation method thereof
CN107412665A (en) * 2017-09-07 2017-12-01 张钰 It is a kind of that there is Chinese medicine composition for relieving the effect of alcohol, preventing and treating alcoholic liver injury and its preparation method and application
CN111642614A (en) * 2020-06-04 2020-09-11 舜朵(德州)医药科技有限公司 Anti-alcohol tabletted candy and preparation method thereof

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102524781A (en) * 2012-01-05 2012-07-04 北京同仁堂国际药业有限公司 Edible composition with alcoholism alleviation function and preparation method thereof
CN104223107A (en) * 2014-09-26 2014-12-24 洛阳华以生物工程有限公司 Healthcare product with liver-protecting, hangover-alleviating and toxin-eliminating functions
CN105998412A (en) * 2016-06-22 2016-10-12 武汉华士特工业生物技术开发有限公司 Antialcoholism formula and preparation method thereof
CN107412665A (en) * 2017-09-07 2017-12-01 张钰 It is a kind of that there is Chinese medicine composition for relieving the effect of alcohol, preventing and treating alcoholic liver injury and its preparation method and application
CN111642614A (en) * 2020-06-04 2020-09-11 舜朵(德州)医药科技有限公司 Anti-alcohol tabletted candy and preparation method thereof

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