CN115120392A

CN115120392A - Thickness-variable personalized titanium mesh and preparation method thereof

Info

Publication number: CN115120392A
Application number: CN202210859850.1A
Authority: CN
Inventors: 党晓兵; 许若谷; 张春雨; 陈贤帅; 杜如虚
Original assignee: Guangdong Zhongke Anchi Biotechnology Co ltd
Current assignee: Guangdong Zhongke Anchi Biotechnology Co ltd
Priority date: 2022-07-21
Filing date: 2022-07-21
Publication date: 2022-09-30
Also published as: WO2024016720A1

Abstract

The invention discloses a thickness-variable personalized titanium mesh and a preparation method thereof, wherein the thickness-variable personalized titanium mesh comprises the following steps: a first thickness region, a second thickness region, and a transition region; first through holes and second through holes which are uniformly arranged exist in the first thickness area, the second thickness area and the transition area, and the first through holes are larger than the second through holes; the first thickness area is connected with the second thickness area, the transition area is located at the connecting portion of the first thickness area and the second thickness area, and the inner surface and the outer surface of the transition area are in smooth transition with the inner surface and the outer surface of the first thickness area and the inner surface and the outer surface of the second thickness area respectively. The invention can ensure that the internal stress of the structure of the prepared personalized titanium net with variable thickness is uniform, so as to take the mechanical property of the personalized titanium net into account and the shaping capability in clinical use.

Description

Thickness-variable personalized titanium mesh and preparation method thereof

Technical Field

The invention relates to the technical field of oral medical equipment, in particular to a personalized titanium net with variable thickness and a preparation method thereof.

Background

Alveolar bone defect refers to insufficient bone mass caused by periodontal disease, apical disease, inflammatory destruction, tumor, tooth loss, congenital malformation and other reasons, which not only increases the implant implantation difficulty, but also affects the expected treatment effect. One method to effectively address the shortage of bone mass is guided bone regeneration surgery. The personalized titanium mesh is being gradually applied to guided bone regeneration surgery due to its good mechanical properties and biocompatibility.

In the prior art, the personalized titanium mesh adopts a fully digital flow design, the edge of the titanium mesh is tightly attached to the surface of the alveolar bone, the in-place stability is better ensured, the risks of soft tissue exposure and the like are reduced, and the personalized titanium mesh has obvious clinical application value for repairing complex alveolar bone defects. However, the thickness of the titanium mesh prepared in the prior art is uniform, after the titanium mesh is implanted into an alveolar bone, the stress in the titanium mesh structure is not uniform, and the mechanical property of the titanium mesh with smaller thickness is poorer; the titanium mesh with larger thickness has poorer shaping capability in clinical use, so that the titanium mesh can not be completely suitable for clinical application of different patients.

Therefore, there is a need for a personalized titanium mesh and a preparation method thereof, which can ensure that the stress in the titanium mesh structure is uniform, so as to take the mechanical properties of the titanium mesh and the shaping ability in clinical use into account.

Disclosure of Invention

The invention provides a variable-thickness personalized titanium mesh and a preparation method thereof, and aims to solve the technical problem that the uniform stress in the titanium mesh structure cannot be ensured in the prior art, so that the mechanical property and the shaping capability in clinical use cannot be considered at the same time.

In order to solve the above technical problem, an embodiment of the present invention provides a variable thickness personalized titanium mesh, including: a first thickness region, a second thickness region, and a transition region; first through holes and second through holes which are uniformly arranged exist in the first thickness area, the second thickness area and the transition area, and the first through holes are larger than the second through holes;

the first thickness area is connected with the second thickness area, the transition area is located at the connecting portion of the first thickness area and the second thickness area, and the inner surface and the outer surface of the transition area are in smooth transition with the inner surface and the outer surface of the first thickness area and the inner surface and the outer surface of the second thickness area respectively.

Compared with the titanium mesh disclosed in the prior art, the personalized titanium mesh with the variable thickness can realize the optimized design of the thickness of the whole structure, the personalized titanium mesh with the variable thickness is designed to have larger thickness in a region with larger stress and smaller thickness in a region with smaller stress through the design of different thickness regions, so that the personalized titanium mesh can be uniformly stressed in the structure after being implanted into an alveolar bone, the mechanical property of the titanium mesh and the shaping capacity in clinical use are considered, and the essential capacity of the personalized titanium mesh in practical clinical application is improved.

Preferably, the thickness of the titanium mesh in the first thickness area is 0.3mm, and the thickness of the titanium mesh in the second thickness area is 0.2 mm.

It can be understood that through the design of different thickness areas, the greater thickness is designed in the first thickness area with the greater stress, and the smaller thickness is designed in the second thickness area with the smaller stress, so that after the implant is implanted into the alveolar bone, the stress of the inside of the structure at different stress positions is uniform, and the mechanical property of the titanium mesh and the shaping capacity in the clinical use are considered.

Accordingly, the present invention also provides a method for preparing a variable thickness personalized titanium mesh, for preparing a variable thickness personalized titanium mesh as described in any one of the above, comprising:

constructing an initial titanium mesh model;

carrying out finite element analysis on the initial titanium mesh model, and dividing a structural stress area of the initial titanium mesh model according to the result of the finite element analysis to obtain a first thickness area and a second thickness area of the initial titanium mesh model;

generating a transition region at the intersection of the first thickness region and the second thickness region, thereby obtaining a personalized titanium mesh model;

and preparing the personalized titanium mesh model to obtain the personalized titanium mesh with variable thickness.

It can be understood that the invention can give consideration to the mechanical property and the structural characteristic of the titanium mesh by introducing the mechanical simulation analysis into the design process of the titanium mesh, and by the optimized design of the whole structure thickness, the invention designs a larger thickness in the area with larger stress and a smaller thickness in the area with smaller stress, so that the personalized titanium mesh can be uniformly stressed in the structure after being implanted into the alveolar bone, and the invention gives consideration to the mechanical property of the titanium mesh and the shaping capability in clinical use, thereby improving the essential capability of the personalized titanium mesh in practical clinical application, simultaneously ensuring the structural integrity of the personalized titanium mesh in the transition area between the areas with different thicknesses, and improving the preparation accuracy and efficiency of the titanium mesh by the whole preparation method.

As a preferred scheme, the constructing of the initial titanium mesh model specifically comprises:

acquiring an alveolar bone CT image of a patient, and constructing an alveolar bone model of the patient according to the alveolar bone CT image;

and constructing an initial titanium mesh model fitting and adapting to the alveolar bone model.

It can be understood that the alveolar bone model of the patient is constructed by acquiring the alveolar bone CT image of the patient, so that an initial titanium mesh model fitting with the alveolar bone model is constructed, the integral structure of the constructed initial titanium mesh model can be fitted with the alveolar bone model, the structural accuracy of the personalized titanium mesh constructed subsequently by the initial titanium mesh model is improved, and the condition that the stress of the integral titanium mesh is changed due to the fact that the existing constructed titanium mesh still needs to be subjected to large-angle and large-range shaping in clinical use is avoided.

As a preferred scheme, the finite element analysis is performed on the initial titanium mesh model, and specifically includes:

importing the initial titanium mesh model into finite element analysis software, and performing geometric cleaning and geometric feature simplification on the initial titanium mesh model;

and carrying out meshing on the initial titanium mesh model after geometric cleaning and geometric feature simplification, and carrying out mechanical analysis and solving on the initial titanium mesh model after meshing after determining the positions of bone screw holes and setting boundary constraint conditions and load conditions, thereby completing finite element analysis on the initial titanium mesh model.

It can be understood that the initial titanium mesh model is guided into finite element analysis software, then geometric cleaning and geometric feature simplification are carried out, the structural accuracy of the whole initial titanium mesh model is improved, through grid division, mechanical analysis and solution are carried out after the positions of the bone screw holes are determined and boundary constraint conditions and load conditions are set, and the accuracy of results obtained through finite element analysis is improved.

Preferably, after the obtaining of the first thickness region and the second thickness region of the initial titanium mesh model, the method further includes:

and carrying out a shell treatment on the first thickness area and the second thickness area.

It can be understood that the first thickness area and the second thickness area are subjected to enclosification treatment, so that the first thickness area and the second thickness area of the initial titanium mesh model can better conform to the structure of practical clinical application, the personalized titanium mesh prepared subsequently can be accurately attached to the alveolar bone of a human body, and foreign body sensation is reduced.

As a preferred scheme, a transition region is generated at the intersection of the first thickness region and the second thickness region, so as to obtain a personalized titanium mesh model, specifically:

determining a transition region generated at the intersection of the first thickness region and the second thickness region according to the results of the finite element analysis;

and performing surface smoothing treatment on the transition area to obtain a personalized titanium mesh model.

It can be understood that the transition region generated at the intersection of the first thickness region and the second thickness region is determined through the result of finite element analysis, so that the stress borne by the transition region between the first thickness region and the second thickness region can be ensured to have higher structural strength, the situation that the structure is easily broken due to the fact that the stress strength of the transition region is not high is avoided, and meanwhile, the surface of the transition region is subjected to smooth processing, so that the overall personalized titanium mesh structure enables a patient to reduce the occurrence of foreign body sensation in practical clinical application.

Preferably, after the obtaining of the personalized titanium mesh model, the method further includes:

and carrying out structural fairing treatment on the surface mutation area of the personalized titanium mesh model.

It can be understood that the surface mutation area of the personalized titanium mesh model is subjected to structural fairing treatment, so that the personalized titanium mesh prepared subsequently can have higher structural strength, and the personalized titanium mesh can be better attached to and adapted to alveolar bones of patients in practical clinical application, and foreign body sensation is reduced.

As a preferred scheme, the preparation of the personalized titanium mesh model to obtain the personalized titanium mesh with variable thickness specifically comprises the following steps:

and preparing the personalized titanium net model by an additive manufacturing technology, and performing stress relief annealing, support removal and surface treatment on the prepared personalized titanium net to obtain the personalized titanium net with variable thickness.

It can be understood that the personalized titanium mesh model is prepared by an additive manufacturing technology, and the prepared personalized titanium mesh is subjected to stress relief annealing, support removal and surface treatment, so that the prepared personalized titanium mesh with the variable thickness has higher material strength and structural strength, meets the actual application requirement, and simultaneously ensures uniform stress inside the structure so as to take the mechanical property of the personalized titanium mesh into account and the shaping capacity in clinical use.

Drawings

FIG. 1: the structure of the personalized titanium mesh with variable thickness provided by the embodiment of the invention is shown schematically;

FIG. 2: the embodiment of the invention provides a flow chart of steps of a method for preparing a personalized titanium mesh with variable thickness.

Detailed Description

The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be obtained by a person skilled in the art without inventive step based on the embodiments of the present invention, are within the scope of protection of the present invention.

Example one

Referring to fig. 1, a thickness-variable personalized titanium mesh provided by an embodiment of the present invention includes: a first thickness region 001, a second thickness region 002, and a transition region 003; first through holes 004 and second through holes 005 which are uniformly arranged exist in the first thickness area 001, the second thickness area 002 and the transition area 003, and the first through holes 004 are larger than the second through holes 005.

The first thickness region 001 and the second thickness region 002 are connected, the transition region 003 is located at the connection position of the first thickness region 001 and the second thickness region 002, and the inner and outer surfaces of the transition region 003 are smoothly transited to the inner and outer surfaces of the first thickness region 001 and the inner and outer surfaces of the second thickness region 002, respectively.

In this embodiment, a portion of the second through hole 005 may be used as a bone screw fixing hole to fix the personalized titanium mesh to the alveolar bone. Further, the material selected from the personalized titanium mesh includes, but is not limited to, pure titanium, titanium alloy, etc. which have good biocompatibility and can avoid the immune system reaction of the human body.

In a preferred embodiment of the present invention, the thickness of the titanium mesh in the first thickness region 001 is 0.3mm, and the thickness of the titanium mesh in the second thickness region 002 is 0.2 mm.

It can be understood that through the design of the thickness regions of different, the great thickness of the regional 001 design of the first thickness that the atress is great, the less thickness of the regional 002 design of the second thickness that the atress is less, guaranteed implant alveolar bone after, the atress of the inside different stress departments of structure is even, compromise the mechanical properties of titanium net and the moulding ability when clinical use.

The embodiment of the invention has the following effects:

compared with the titanium mesh disclosed by the prior art, the thickness-variable personalized titanium mesh disclosed by the invention can realize the optimized design of the thickness of the whole structure, the personalized titanium mesh is designed to have larger thickness in the area with larger stress and smaller thickness in the area with smaller stress through the design of different thickness areas, so that the personalized titanium mesh can be uniformly stressed in the structure after being implanted into the alveolar bone, the mechanical property of the titanium mesh and the shaping capacity in clinical use are taken into consideration, and the substantial capability of the personalized titanium mesh in practical clinical application is improved.

Example two

Accordingly, referring to fig. 2, the present invention further provides a method for manufacturing a variable thickness personalized titanium mesh, which is used for manufacturing the variable thickness personalized titanium mesh according to the first embodiment, and includes the following steps S101 to S104:

s101: and constructing an initial titanium mesh model.

acquiring an alveolar bone CT image of a patient, and constructing an alveolar bone model of the patient according to the alveolar bone CT image; and constructing an initial titanium mesh model which is fit with the alveolar bone model.

It should be noted that, according to the alveolar bone defect condition, the personalized titanium mesh with uniform thickness is designed, the profile structure of the titanium mesh should meet the clinical requirement, and the defective alveolar bone region is completely covered by the outer contour.

S102: and carrying out finite element analysis on the initial titanium mesh model, and dividing a structural stress area of the initial titanium mesh model according to the result of the finite element analysis to obtain a first thickness area and a second thickness area of the initial titanium mesh model.

As a preferred scheme, the finite element analysis is performed on the initial titanium mesh model, specifically:

importing the initial titanium mesh model into finite element analysis software, and performing geometric cleaning and geometric feature simplification on the initial titanium mesh model; and carrying out meshing on the initial titanium mesh model after geometric cleaning and geometric feature simplification, and carrying out mechanical analysis and solving on the initial titanium mesh model after meshing after determining the positions of bone screw holes and setting boundary constraint conditions and load conditions, thereby completing finite element analysis on the initial titanium mesh model.

It should be noted that finite element analysis software including but not limited to Ansys, Abaqus, LMS-Samtech, Algor, Femap/NX nanostran, hyper works, COMSOL Multiphysics, FEPG, etc. introduces the initial titanium mesh model into the finite element analysis software and performs appropriate geometric cleaning and geometric feature simplification on the structural model. And selecting proper body units for grid division, wherein the unit division model mainly comprises hexahedron units. And setting materials for the finite element model, and assigning the material-related attributes to the finite element units. Selecting a proper bone nail hole position and setting boundary constraint conditions by combining clinical information; and setting a load condition in the stressed area. And setting a solving model as static analysis. And leading the initial titanium mesh model into a solver to be solved, and performing mechanical analysis, thereby completing finite element analysis of the initial titanium mesh model.

S103: and generating a transition region at the intersection of the first thickness region and the second thickness region, thereby obtaining a personalized titanium mesh model.

and carrying out encapsidation treatment on the first thickness area and the second thickness area.

It should be noted that a larger thickness value is set for the corresponding portion of the first thickness region, and the encapsidation process is performed; and setting a smaller thickness value for the corresponding part of the second thickness area, and carrying out the encapsidation treatment.

It can be understood that the first thickness area and the second thickness area are subjected to shell treatment, so that the first thickness area and the second thickness area of the initial titanium mesh model can better conform to the structure of practical clinical application, the personalized titanium mesh prepared subsequently can be accurately attached to the alveolar bone of a human body, and foreign body sensation is reduced.

S104: and preparing the personalized titanium net model to obtain the personalized titanium net with variable thickness.

determining a transition region generated at the intersection of the first thickness region and the second thickness region according to the results of the finite element analysis; and performing surface smoothing treatment on the transition area to obtain a personalized titanium mesh model.

It should be noted that the region where the first thickness region intersects with the second thickness region, i.e., the region where the thickness has an abrupt change, is divided into transition regions. Further, the area is subjected to smoothing treatment, particularly the part with the thickness suddenly changed, and surface smoothing treatment is carried out, so that the thicknesses of the first thickness area and the second thickness area are gradually changed in a transition mode.

The personalized titanium mesh model is locally trimmed, and the surface mutation region is subjected to structural fairing treatment, so that the model design of the personalized titanium mesh with variable thickness is completed.

The titanium mesh is processed and manufactured by using an additive manufacturing technology, the selected material can be pure titanium or titanium alloy powder, and the selected processing method can be a laser-based powder bed melting process. And after the additive manufacturing is finished, post-processing the titanium mesh by processes such as stress annealing, support removal, surface treatment and the like.

The embodiment of the invention has the following effects:

according to the embodiment of the invention, mechanical simulation analysis is introduced into the design process of the titanium mesh, the mechanical property and the structural characteristic of the titanium mesh can be considered, the larger thickness is designed in the area with larger stress and the smaller thickness is designed in the area with smaller stress through the optimized design of the thickness of the whole structure, so that the personalized titanium mesh can be uniformly stressed in the structure after being implanted into the alveolar bone, the mechanical property and the shaping capacity of the titanium mesh during clinical use are considered, the essential capacity of the personalized titanium mesh in practical clinical application is improved, meanwhile, the structural integrity of the personalized titanium mesh is ensured in the transition area between areas with different thicknesses, and the preparation accuracy and efficiency of the titanium mesh are improved by the integral preparation method.

The above-mentioned embodiments are provided to further explain the objects, technical solutions and advantages of the present invention in detail, and it should be understood that the above-mentioned embodiments are only examples of the present invention and are not intended to limit the scope of the present invention. It should be understood that any modifications, equivalents, improvements and the like, which come within the spirit and principle of the invention, may occur to those skilled in the art and are intended to be included within the scope of the invention.

Claims

1. A variable thickness personalized titanium mesh, comprising: a first thickness region, a second thickness region, and a transition region; first through holes and second through holes which are uniformly arranged exist in the first thickness area, the second thickness area and the transition area, and the first through holes are larger than the second through holes;

the first thickness area is connected with the second thickness area, the transition area is located at the connecting position of the first thickness area and the second thickness area, and the inner surface and the outer surface of the transition area are in smooth transition with the inner surface and the outer surface of the first thickness area and the inner surface and the outer surface of the second thickness area respectively.

2. The personalized titanium web of variable thickness according to claim 1, wherein the thickness of the titanium web in the first thickness zone is 0.3mm and the thickness of the titanium web in the second thickness zone is 0.2 mm.

3. A method for producing a personalized titanium web of variable thickness, for producing a personalized titanium web of variable thickness according to claims 1-2, comprising:

constructing an initial titanium mesh model;

and preparing the personalized titanium net model to obtain the personalized titanium net with variable thickness.

4. The method for preparing a personalized titanium mesh with variable thickness according to claim 3, wherein the constructing of the initial titanium mesh model is specifically:

and constructing an initial titanium mesh model which is fit with the alveolar bone model.

5. A method for the production of a personalized titanium mesh of variable thickness according to claim 3, characterized in that said initial titanium mesh model is subjected to finite element analysis, in particular:

and carrying out meshing on the initial titanium mesh model after geometric cleaning and geometric feature simplification, and carrying out mechanical analysis and solution on the initial titanium mesh model after meshing after determining the position of the bone screw hole and setting boundary constraint conditions and load conditions, thereby completing finite element analysis on the initial titanium mesh model.

6. The method of claim 3, further comprising, after said obtaining the first thickness region and the second thickness region of the initial titanium mesh model:

7. The method for preparing the personalized titanium mesh with the variable thickness according to claim 3, wherein a transition region is generated at the intersection of the first thickness region and the second thickness region, so as to obtain a personalized titanium mesh model, and the method comprises the following steps:

8. The method of claim 7, further comprising, after said obtaining a personalized titanium mesh model:

9. The method for preparing the personalized titanium mesh with the variable thickness according to claim 3, wherein the personalized titanium mesh model is prepared to obtain the personalized titanium mesh with the variable thickness, and the method comprises the following specific steps: