CN115024765A - Ultraviolet light source type endoscope for in-vivo minimally invasive in-situ gelling, curing type injection mechanism thereof and in-situ gelling method - Google Patents
Ultraviolet light source type endoscope for in-vivo minimally invasive in-situ gelling, curing type injection mechanism thereof and in-situ gelling method Download PDFInfo
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- A61B17/00491—Surgical glue applicators
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- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/00234—Surgical instruments, devices or methods, e.g. tourniquets for minimally invasive surgery
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/34—Trocars; Puncturing needles
- A61B17/3478—Endoscopic needles, e.g. for infusion
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- A—HUMAN NECESSITIES
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- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/00491—Surgical glue applicators
- A61B2017/005—Surgical glue applicators hardenable using external energy source, e.g. laser, ultrasound
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Abstract
The ultraviolet light source type endoscope device for the minimally invasive in-situ gelling in vivo is provided with an injector for loading photosensitive hydrogel and placing the photosensitive hydrogel at an action point and a light guide part for conducting ultraviolet rays to the action point, wherein the light guide part is assembled on an injection needle of the injector. The light guide part is movably sleeved on the outer surface of the injection needle, and the length of the light guide part is smaller than that of the injection needle. The light guide part is provided with a sleeve and optical fibers, the optical fibers are located inside the sleeve, and the optical fibers are distributed on the periphery of the injection needle. The ultraviolet light source type minimally invasive endoscope integrates the injection operation and the real-time light curing function, so that the complicated and redundant operation that the light source needs to be re-placed for curing after materials are placed in a surgical operation is avoided, and the ultraviolet light source type minimally invasive endoscope has the characteristics of simple structure and simplicity and convenience in operation.
Description
Technical Field
The invention relates to the technical field of clinical medical instruments, in particular to an ultraviolet light source type endoscope for in-vivo minimally invasive in-situ gel forming, a curing type injection mechanism thereof and an in-situ gel forming method.
Background
At present, the biological material is widely applied to clinical disciplines such as four fields of orthopedics, cardiovascular and cerebrovascular, oral and ophthalmological and wound repair as an upstream material of a medical industry chain. Meanwhile, with the improvement of love consciousness and aesthetic consciousness, the minimally invasive surgery becomes an operation mode which is considered by medical care and patients in the field of surgical operations. Therefore, the implanted biomedical material conforming to the minimally invasive surgery becomes the product with the largest market share at present, and is widely applied to hemostasis, treatment and repair in the surgery. Among the medical biomaterials, hydrogels are the hot spot for the research and transformation of this class of materials.
Laparoscope is similar to electronic gastroscope, and is a medical instrument with a miniature camera, and laparoscopic surgery is a surgery performed by using laparoscope and related instruments. Wherein the laparoscopic stab card is a tool used in laparoscopic surgery. One end of the laparoscope poking card is inserted into the skin, the other end of the laparoscope poking card is exposed on the surface of the skin, a special channel is established by the laparoscope poking card, and surgical instruments such as slender surgical forceps, an electric hook, an ultrasonic knife, a lens of an endoscope and the like enter the abdominal cavity through the laparoscope poking card so as to perform surgical operation of cutting off a focus.
Because the photosensitive hydrogel needs ultraviolet light or infrared light excitation to be cured and crosslinked, in laparoscopic surgery, the injection device is usually firstly inserted into the laparoscopic stab card to inject the hydrogel into the focus position, the injection device is taken out of the laparoscopic stab card after injection is finished, and then the ultraviolet or infrared light source device is inserted into the laparoscopic stab card to perform crosslinking curing after the hydrogel in the focus position is irradiated. The operation is complicated and redundant, and the actual conversion of the photo-initiation hydrogel is greatly limited.
Therefore, aiming at the defects of the prior art, the ultraviolet light source type endoscope for in-vivo minimally invasive in-situ gel forming, the curing type injection mechanism and the in-situ gel forming method thereof, which have simple structure and simple and convenient operation, are provided to solve the defects of the prior art.
Disclosure of Invention
The ultraviolet light source type endoscope device for in-vivo minimally invasive in-situ gel formation is characterized by integrating injection operation and real-time photocuring functions, and being capable of irradiating, crosslinking and curing hydrogel in real time after the hydrogel is injected into a target position.
The object of the invention is achieved by the following technical measures.
The ultraviolet light source type endoscope device for in-vivo minimally invasive in-situ gelling is provided with a curing type injection mechanism, wherein the curing type injection mechanism is provided with an injector for loading photosensitive hydrogel and placing the photosensitive hydrogel at an action point and a light guide part for conducting ultraviolet rays to the action point, the light guide part is sleeved on an injection needle of the injector, and the light guide part and the injection needle extend into a laparoscope poking card.
Specifically, the light guide part is movably sleeved on the outer surface of the injection needle, and the length of the light guide part is smaller than that of the injection needle.
Specifically, the length of the light guide portion is defined as a, the length of the injection needle is defined as B, and B — a is 2cm to 5 cm.
Specifically, the light guide part is provided with a sleeve and optical fibers, the optical fibers are located inside the sleeve, and the optical fibers are distributed on the periphery of the injection needle.
Specifically, the side wall of the inlet end of the sleeve is provided with an optical fiber connecting hole, and the axis of the optical fiber connecting hole is perpendicular to the axis of the sleeve.
Specifically, one end of the optical fiber enters the inside of the sleeve from the optical fiber connecting hole and is flush with the insertion end of the optical fiber sleeve, and the other end of the thin optical fiber is connected with an external ultraviolet light source.
Specifically, the optical fibers are arranged on the periphery of the injection needle in an annular and equidistant mode.
Specifically, the optical fiber is encapsulated with a black rubber layer.
Specifically, the number of the optical fibers is 3-10, and the diameter of the optical fibers is 0.5-1 mm.
Specifically, the thickness of the black rubber layer ranges from 100 μm to 200 μm.
Another object of the present invention is to provide a solidified injection mechanism, which avoids the disadvantages of the prior art, and the light guide portion and the injection needle of the solidified injection mechanism are both tubular structures, and the light guide portion is sleeved on the injection needle to form a concentric structure, which can save space, and facilitate the simultaneous completion of two operations, i.e., drug injection and photo-solidification, in a narrow laparoscope trocar.
The object of the invention is achieved by the following technical measures.
Provides a curing type injection mechanism which is assembled in the ultraviolet light source type endoscope device for in-vivo minimally invasive in-situ gelling.
Specifically, the light guide part and the injection needle of the curing type injection mechanism integrally extend into the laparoscope poking card.
The invention also aims to avoid the defects of the prior art and provide the in-situ gel forming method, the in-vivo minimally invasive in-situ gel forming is carried out by adopting the ultraviolet light source type endoscope device, the hydrogel can be immediately cured by illumination after being injected, the operation time can be saved, and the curing efficiency of the hydrogel can be improved.
The object of the invention is achieved by the following technical measures.
Providing an in-situ gelling method, which is carried out by adopting the ultraviolet light source type endoscope device for in-vivo minimally invasive in-situ gelling, and comprises the following specific steps:
s1, connecting the curing type injection mechanism with an external ultraviolet light source through an optical fiber of the light guide part;
s2, integrally extending the light guide part and the injection needle of the solidified injection mechanism into the laparoscope poking card to reach the upper part of the target position;
s3, the injection needle of the solidified injection mechanism extends out of the insertion end of the light guide part sleeve to reach the target position, and simultaneously pushes the push rod of the injector to inject the hydrogel in the needle cylinder to the target position;
s4, after the hydrogel is injected by the injection needle, the hydrogel is withdrawn from the target position into the sleeve of the light guide part or the light guide part is completely withdrawn;
s5, immediately starting an external ultraviolet light source after the step S4 is completed, and irradiating the photosensitive hydrogel at the target position by the ultraviolet light source through an optical fiber to enable the photosensitive hydrogel to be crosslinked and cured at the target position to form the gel.
The ultraviolet light source type endoscope device for in-vivo minimally invasive in-situ gelatinization is provided with a curing type injection mechanism, the curing type injection mechanism is provided with an injector for loading photosensitive hydrogel and placing the photosensitive hydrogel at an action point and a light guide part for conducting ultraviolet rays to the action point, the light guide part is sleeved on an injection needle of the injector, and the light guide part and the injection needle extend into a laparoscope poking card. The ultraviolet light source type minimally invasive endoscope integrates the injection operation and the real-time photocuring function, and can perform light irradiation crosslinking curing on hydrogel in real time after the hydrogel is injected at a target position by using the device, so that the tedious and redundant operation that the light source is required to be re-placed for curing after materials are placed in a surgical operation is avoided, and the ultraviolet light source type minimally invasive endoscope has the characteristics of simple structure and simplicity and convenience in operation. Meanwhile, the ultraviolet light source type endoscope device for in-vivo minimally invasive in-situ gel forming is adopted to carry out in-situ gel forming, so that the operation time can be saved and the curing efficiency of hydrogel can be improved.
Drawings
The invention is further illustrated by means of the attached drawings, the content of which is not in any way limiting.
Fig. 1 is a schematic structural view of a solid injection mechanism in embodiment 1 of the present invention.
Fig. 2 is a schematic view of the assembly of the sheath, optical fiber and injection needle in example 3 of the present invention.
Fig. 3 is a schematic structural view of a light guide portion in example 4 of the present invention.
Fig. 4 is a schematic structural view of an optical fiber having a black rubber layer in embodiment 7 of the present invention.
Fig. 5 is a schematic view of the structure of the needle-projecting sheath according to embodiment 9 of the present invention.
In fig. 1 to 5, there are included:
A light guide part 200, a sleeve 210, an optical fiber 220, a black rubber layer 221, an optical fiber connection hole 230,
An external ultraviolet light source 300.
Detailed Description
The invention is further illustrated by the following examples.
Example 1.
An ultraviolet light source type endoscope device for in-vivo minimally invasive in-situ gel formation is provided with a curing type injection mechanism, as shown in figure 1, the curing type injection mechanism is provided with an injector 100 for loading photosensitive hydrogel and placing the photosensitive hydrogel at an action point and a light guide part 200 for conducting ultraviolet rays to the action point, the light guide part is sleeved on an injection needle 110 of the injector 100, and the light guide part 200 and the injection needle 110 extend into a laparoscope poking card.
The injector 100 is a hand-held injector, and is provided with a push rod 130, a syringe 120 and an injection needle 110, in this embodiment, hydrogel is loaded in the syringe 120, and the hydrogel in the syringe 120 can be pushed out from the injection needle 110 by the push rod 130 to be injected to a target position.
The hydrogel is a very excellent photoresponse functional material. Due to the chemical and physical diversity and photoresponse capability of the hydrogel, the photoresponse hydrogel becomes an ideal choice in multiple fields of biological materials, medicine, soft robots and the like. After the photosensitive hydrogel is irradiated by ultraviolet rays, a crosslinking reaction occurs, and the liquid state is converted into the solid state.
The light guide part 200 can transmit light to a lesion site (i.e., an action point) to cause a curing and crosslinking reaction of the photosensitive hydrogel injected into the lesion site.
According to the ultraviolet light source type cavity mirror device, the light guide part 200 is arranged on the injection needle 110 of the injector 100, after the photosensitive hydrogel is injected to the target position through the injector 100, the photosensitive hydrogel can be immediately solidified through the light guide part 200, and the injector 100 does not need to be taken out again and then inserted into an external light source for solidification.
Example 2.
An ultraviolet light source type endoscope device for in-vivo minimally invasive in-situ gel formation is shown in figure 1, and the other structures are the same as those in embodiment 1, except that: the light guide 200 is movably mounted on the outer surface of the injection needle 110, and the length of the light guide 200 is smaller than the length of the injection needle 110.
The light guide unit 200 is movably mounted on the outer surface of the injection needle 110, so that the light guide unit 200 and the injection needle 110 can be kept in the same direction at any time, and the light guide unit 200 does not need to be aligned after the photosensitive hydrogel is injected into the injection needle 110.
Due to the relative movement between the light guide 200 and the injection needle 110 and the fact that the length of the injection needle 110 is greater than that of the light guide 200, the distance between the needle tip of the injection needle 110 and the insertion end of the light guide 200 can be controlled.
At the target site, the catheter portion is illuminated over the hydrogel to solidify the hydrogel, but the injection needle 110 is required to inject the hydrogel directly to the target site. In practice, the light guide 200 is first inserted to the upper side of the target position via laparoscope, and since the injection needle 110 is movable in the light guide 200 and has a length greater than that of the light guide 200, the injection needle 110 can extend out of the light guide 200 to inject the hydrogel into the target position, and after the injection, the injection needle 110 is retracted to be flush with the light guide 200 or completely withdrawn from the light guide 200.
Compared with embodiment 1, the ultraviolet light source type endoscope device for in vivo minimally invasive in-situ gel formation of the embodiment can facilitate the delivery of the light-sensitive hydrogel by the injection needle 110, and does not affect the work of the light guide part 200.
Example 3.
An ultraviolet light source type endoscope device for in-vivo minimally invasive in-situ gel forming is shown in figure 2, and the other structures are the same as those in embodiment 2, except that: the light guide 200 is provided with a sleeve 210 and optical fibers 220, the optical fibers 220 are located inside the sleeve 210, and the optical fibers 220 are distributed on the outer circumference of the injection needle 110.
The concentric tube structure formed by the light guide 200 and the injection needle 110 has high structural stability. The optical fiber 220 is disposed inside the sleeve 210, and has a better protection effect on the optical fiber 220. Meanwhile, the sleeve 210 integrates the injection function and the light conduction function, has high space utilization rate and is very suitable for being used in a laparoscope poking card with narrow space.
The optical fiber 220 has the excellent performances of small diameter, light weight, chemical corrosion resistance, electromagnetic interference resistance and the like, and can be used as a communication medium and an optical fiber 220 sensor. In the medical field, particularly in the field of minimally invasive surgery, the optical fiber 220 is commonly used in medical endoscopic devices because of the thin, flexible, and bendable nature of the optical fiber 220 to any degree. In the present application, the optical fiber 220 is used to conduct light to illuminate the photosensitive hydrogel at the target site.
Compared with the embodiment 1, the ultraviolet light source type endoscope device for in-vivo minimally invasive in-situ gelling of the embodiment has higher stability, safety and space utilization rate.
Example 4.
An ultraviolet light source type endoscope device for in-vivo minimally invasive in-situ gel forming is shown in fig. 3, and the other structures are the same as those in embodiment 3, except that: the side wall of the entrance end of the ferrule 210 is provided with a fiber connection hole 230, and the axis of the fiber connection hole 230 and the axis of the ferrule 210 are perpendicular to each other.
The fiber connection hole 230 is formed in the sidewall of the entrance end of the cannula 210 so as not to block the insertion and extraction of the injection needle 110 into and out of the cannula 210. The axis of the optical fiber connection hole 230 and the axis of the ferrule 210 are perpendicular to each other, so that the loss of the optical fiber 220 to the optical energy conduction can be reduced.
Compared with the embodiment 1, the ultraviolet light source type endoscope device for in-vivo minimally invasive in-situ gelling can synchronously perform photosensitive hydrogel injection and light conduction, and improve the operation efficiency. The axis of the optical fiber connection hole 230 and the axis of the sleeve 210 are perpendicular to each other, so that the loss of the optical fiber 220 to the optical energy conduction is reduced, and the optical transmission efficiency is ensured.
Example 5.
An ultraviolet light source type endoscope device for in-vivo minimally invasive in-situ gel forming is shown in fig. 3, and the other structures are the same as those in embodiment 4, except that: one end of the optical fiber 220 enters the inside of the ferrule 210 from the optical fiber connection hole 230 and is flush with the insertion end of the ferrule 210, and the other end of the optical fiber 220 is connected with the external ultraviolet light source 300. The external ultraviolet light source 300 is an OmniCure series ultraviolet curing system.
The OmniCure series ultraviolet curing system has the characteristics of high controllability, high reliability and high-intensity irradiance.
The external ultraviolet light source 300 emits ultraviolet light (250-300 nm) with a certain wavelength, and the ultraviolet light is transmitted through the optical fiber 220 and irradiates on the photosensitive hydrogel of the lesion part to cause polymerization reaction, so that solid-state conversion is completed.
The end of the optical fiber 220 is flush with the insertion end of the ferrule 210 for optimal light transmission. When the end of the optical fiber 220 is inside the ferrule 210, the light transmitted by the light is blocked by the wall of the ferrule 210 to form a light beam, and the light beam forms a circular light spot with a small area at the target position. When the end of the optical fiber 220 is outside the ferrule 210, the end of the optical fiber 220 is easily worn out because it is not protected by the ferrule 210, and simultaneously, due to the thin and flexible characteristics of the optical fiber 220, the direction of the end of the optical fiber 220 is easily scattered, resulting in the scattering of the direction of light, and reducing the illumination intensity as a whole.
Compared with embodiment 1, this embodiment has higher radiation efficiency because the optical fiber 220 is connected to the OmniCure series ultraviolet curing system, and the end of the optical fiber 220 is flush with the insertion end of the fish tube 210.
Example 6.
An ultraviolet light source type endoscope device for in-vivo minimally invasive in-situ gel forming is shown in fig. 2, and the other structures are the same as those in embodiment 5, except that: the optical fibers 220 are arranged in a ring shape at equal intervals on the outer circumference of the injection needle 110.
The optical fibers 220 are arranged in a ring shape at equal intervals on the outer circumference of the injection needle 110, so that the irradiation of light on the photosensitive hydrogel is more uniform.
Compared with the embodiment 1, the ultraviolet light source type endoscope device for in-vivo minimally invasive in-situ gel formation has higher crosslinking and curing efficiency on the photosensitive hydrogel because the optical fibers 220 are arranged in a ring shape at equal intervals.
Example 7.
An ultraviolet light source type endoscope device for in-vivo minimally invasive in-situ gel formation is shown in fig. 4, and the other structures are the same as those in embodiment 6, except that: the optical fiber 220 is encapsulated with a black rubber layer 221, and the thickness range of the black rubber layer 221 is 150 um.
The black rubber layer 221 provides mechanical protection and isolation for the optical fiber 220 to reduce the transmission loss of ultraviolet light energy.
It should be noted that the thickness of the black rubber layer 221 encapsulated by the optical fiber 220 is not limited to 150um in this embodiment, but may be selected from 100 μm to 200 μm as needed, and specifically may be flexibly selected according to the diameter of the sleeve 210, the diameter of the injection needle 110, or the crosslinking and curing efficiency of the photosensitive hydrogel.
Compared with embodiment 1, the ultraviolet light source type endoscope device for minimally invasive in-vivo in-situ gel formation in the embodiment can reduce the energy loss of ultraviolet light transmitted in the optical fiber 220, so that the curing efficiency of the photosensitive hydrogel is higher.
Example 8.
The other structures of the ultraviolet light source type endoscope device for in-vivo minimally invasive in-situ gelling are the same as those in embodiment 7, and the difference is that: the number of fibers 220 is 5; the diameter of the optical fiber 220 is 0.8 mm; the diameter of the injection needle 110 is 1.5 mm; the sleeve 210 is 4mm in diameter.
It should be noted that the number of the optical fibers 220 is not limited to 5 in this embodiment, and 3 to 10 optical fibers may be selected according to the requirement, and specifically, the number may be flexibly selected according to the curing efficiency of the photosensitive hydrogel or the size of the space of the sleeve 210.
It should be noted that the diameter of the optical fiber 220 is not limited to 0.8mm in this embodiment, but may be selected from 0.5mm to 1mm as needed, and specifically, may be flexibly selected according to the curing efficiency of the photosensitive hydrogel or the size of the space of the sleeve 210.
It should be noted that the diameter of the injection needle 110 is not limited to 1.5mm in this embodiment, but may be selected from 1mm to 2mm as required, and specifically, may be flexibly selected according to the diameter of the laparoscopic trocar, the diameter of the cannula 210, or the amount of the photosensitive hydrogel at the target site.
It should be noted that the diameter of the cannula 210 is not limited to 4cm in the embodiment, but may also be selected from 3mm to 5mm as required, and specifically, may be flexibly selected according to the size of the laparoscopic trocar space or the diameter of the injection needle 110.
The ultraviolet light source type minimally invasive endoscope integrates injection operation and real-time light curing functions, all operations can be completed in a single hole, so that complicated and redundant operations of placing materials in a surgical operation and then placing a light source again for curing are avoided, and the ultraviolet light source type minimally invasive endoscope has the characteristics of simple structure and simplicity and convenience in operation.
Example 9.
An ultraviolet light source type endoscope device for in-vivo minimally invasive in-situ gel formation is shown in fig. 5, and the other structures are the same as those in the embodiment 8, and the difference is that: the length of light guide 200 was defined as a, the length of injection needle 110 was defined as B, and B — a was 3.5 cm.
The length of the injection needle 110 is 15cm, the length of the cannula 210 is 7.5cm, and the length of the optical fiber 220 is 75 cm.
It should be noted that the size of B-a is not limited to 3.5cm in this embodiment, but may be selected from 2mm to 5mm as needed, and specifically, may be flexibly selected according to the distance from the insertion end of the cannula 210 to the photosensitive hydrogel.
It should be noted that the length of the injection needle 110 is not limited to 15cm in the present embodiment, but may be selected from 10cm to 20cm as needed, specifically, may be flexibly selected according to the depth of the target site and the length of the cannula 210.
It should be noted that the length of the cannula 210 is not limited to 5cm in this embodiment, but may be selected from 5cm to 10cm as needed, and specifically may be flexibly selected according to the depth of the target location.
It should be noted that the length of the optical fiber 220 is not limited to 75cm in this embodiment, but may be selected from 50cm to 100cm as needed, and specifically, the length of the sleeve 210 may be flexibly selected.
The ultraviolet light source type minimally invasive endoscope integrates injection operation and real-time light curing functions, all operations can be completed in a single hole, so that complicated and redundant operations of placing materials in a surgical operation and then placing a light source again for curing are avoided, and the ultraviolet light source type minimally invasive endoscope has the characteristics of simple structure and simplicity and convenience in operation.
Example 10.
A curing type injection mechanism, which is assembled in the ultraviolet light source type endoscope device for in-vivo minimally invasive in-situ gelling of embodiments 1 to 9, in particular, a light guide part and an injection needle of the curing type injection mechanism integrally extend into a laparoscope poking card.
This solidification formula injection mechanism's light guide part and syringe needle are the tubular structure, and light guide part cover forms the concentric circles structure on locating the syringe needle, and this structure can save space, conveniently accomplishes two kinds of operation operations of medicine injection and photocuring simultaneously in narrow and small peritoneoscope stabs the card.
Example 11.
An in-situ gelling method using the uv light source type endoscopic device for in-vivo minimally invasive in-situ gelling according to examples 1 to 9.
The in-situ gel forming method comprises the following steps:
s1, connecting the curing type injection mechanism with an external ultraviolet light source through an optical fiber of the light guide part;
s2, integrally extending the light guide part and the injection needle of the solidified injection mechanism into the laparoscope poking card to reach the upper part of the target position;
s3, the injection needle of the solidified injection mechanism extends out of the insertion end of the light guide part sleeve to reach the target position, and simultaneously pushes the push rod of the injector to inject the hydrogel in the needle cylinder to the target position;
s4, after the hydrogel is injected by the injection needle, the hydrogel is withdrawn from the target position into the sleeve of the light guide part or the light guide part is completely withdrawn;
s5, immediately starting an external ultraviolet light source after the step S4 is completed, and irradiating the photosensitive hydrogel at the target position by the ultraviolet light source through an optical fiber to enable the photosensitive hydrogel to be crosslinked and cured at the target position to form the gel.
According to the in-situ gelling method, the ultraviolet light source type endoscope device for in-vivo minimally invasive in-situ gelling is used, the hydrogel can be immediately subjected to illumination curing after being injected, the operation time can be saved, and the curing efficiency of the hydrogel can be improved.
Finally, it should be noted that the above embodiments are only used for illustrating the technical solutions of the present invention and not for limiting the protection scope of the present invention, and although the present invention is described in detail with reference to the preferred embodiments, it should be understood by those skilled in the art that modifications or equivalent substitutions can be made on the technical solutions of the present invention without departing from the spirit and scope of the technical solutions of the present invention.
Claims (10)
1. An ultraviolet light source type endoscope device for in-vivo minimally invasive in-situ gel formation is characterized in that a curing type injection mechanism is arranged;
the curing type injection mechanism is provided with an injector for loading the photosensitive hydrogel and placing the photosensitive hydrogel at an action point and a light guide part for transmitting ultraviolet rays to the action point;
the light guide part is sleeved on an injection needle of the injector;
the light guide part and the injection needle integrally extend into the laparoscope poking card.
2. The ultraviolet light source type endoscope device for in vivo minimally invasive in-situ gel formation according to claim 1, wherein the light guide part is movably sleeved on the outer surface of the injection needle, and the length of the light guide part is smaller than that of the injection needle.
3. The ultraviolet light source type endoscope device for in vivo minimally invasive in-situ gel formation according to claim 2, wherein the length of the light guide part is defined as A, the length of the injection needle is defined as B, and B-A is 2 cm-5 cm.
4. The ultraviolet light source type endoscope device for in vivo minimally invasive in-situ gelation according to any one of claims 1 to 3, wherein the light guide part is provided with a sleeve and optical fibers, the optical fibers are positioned inside the sleeve, and the optical fibers are distributed on the periphery of the injection needle.
5. The ultraviolet light source type endoscope device for in vivo minimally invasive in-situ gel formation according to claim 4, wherein the side wall of the inlet end of the sleeve is provided with an optical fiber connecting hole; the axis of the optical fiber connecting hole is perpendicular to the axis of the sleeve.
6. The ultraviolet light source type endoscope device for in-vivo minimally invasive in-situ gelation according to claim 5, wherein one end of the optical fiber enters the inside of the sleeve from the optical fiber connecting hole and is flush with the insertion end of the optical fiber sleeve, and the other end of the optical fiber is connected with an external ultraviolet light source.
7. The ultraviolet light source type endoscope device for in vivo minimally invasive in-situ gel formation according to claim 6, wherein the optical fibers are annularly and equidistantly arranged on the periphery of the injection needle.
8. The ultraviolet light source type endoscope device for in vivo minimally invasive in-situ gelation according to claim 7, wherein the outer surface of the optical fiber is encapsulated with a black rubber layer, and the thickness of the black rubber layer ranges from 100 μm to 200 μm;
the number of the optical fibers is 3-10;
the diameter range of the optical fiber is 0.5 mm-1 mm.
9. The utility model provides a solidification formula injection mechanism for assemble in chamber mirror device, its characterized in that: the curing injection mechanism in the ultraviolet light source type cavity mirror device for in vivo minimally invasive in-situ gel formation according to any one of claims 1 to 8.
10. An in-situ gel forming method, which is carried out by the ultraviolet light source type endoscope device for in-vivo minimally invasive in-situ gel forming according to any one of claims 1 to 8, and the in-situ gel forming comprises the following specific steps:
s1, connecting the curing type injection mechanism with an external ultraviolet light source through an optical fiber of the light guide part;
s2, integrally extending the light guide part and the injection needle of the solidified injection mechanism into the laparoscope poking card to reach the upper part of the target position;
s3, the injection needle of the solidified injection mechanism extends out of the insertion end of the light guide part sleeve to reach the target position, and simultaneously pushes the push rod of the injector to inject the hydrogel in the needle cylinder to the target position;
s4, after the hydrogel is injected by the injection needle, the hydrogel is withdrawn from the target position into the sleeve of the light guide part or the light guide part is completely withdrawn;
s5, immediately starting an external ultraviolet light source after the step S4 is completed, and irradiating the photosensitive hydrogel at the target position by the ultraviolet light source through an optical fiber to enable the photosensitive hydrogel to be crosslinked and cured at the target position to form the gel.
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| CN202210680804.5A CN115024765A (en) | 2022-06-16 | 2022-06-16 | Ultraviolet light source type endoscope for in-vivo minimally invasive in-situ gelling, curing type injection mechanism thereof and in-situ gelling method |
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| CN202210680804.5A CN115024765A (en) | 2022-06-16 | 2022-06-16 | Ultraviolet light source type endoscope for in-vivo minimally invasive in-situ gelling, curing type injection mechanism thereof and in-situ gelling method |
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| CN202210680804.5A Pending CN115024765A (en) | 2022-06-16 | 2022-06-16 | Ultraviolet light source type endoscope for in-vivo minimally invasive in-situ gelling, curing type injection mechanism thereof and in-situ gelling method |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN117797362A (en) * | 2024-01-10 | 2024-04-02 | 北京大学口腔医学院 | Photosensitive therapeutic device and assembling method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN117797362A (en) * | 2024-01-10 | 2024-04-02 | 北京大学口腔医学院 | Photosensitive therapeutic device and assembling method thereof |
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