CN114848779A - Tablet suitable for old people bone fracture and preparation method thereof - Google Patents
Tablet suitable for old people bone fracture and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a tablet suitable for senile bone fracture and a preparation method thereof, and the tablet is prepared from a first formula, a second formula, a third formula and a fourth formula, wherein the first formula is prepared from the following raw materials: radix Codonopsis, radix Angelicae sinensis, rhizoma Ligustici Chuanxiong, fructus Chaenomelis, Carthami flos, semen Persicae, pericarpium Citri Reticulatae viride, radix Paeoniae Rubra, Notoginseng radix, Eupolyphaga Seu Steleophaga, pollen Typhae, and herba Lycopi; the second formula is prepared from the following raw materials: sargentgloryvine stem, common cephalanoplos herb, corydalis tuber, salvia miltiorrhiza, akebia stem, tree peony bark and radix rehmanniae; the third prescription is prepared from the following raw materials: flos Rosae chinensis, semen Vaccariae, herba Leonuri, Achyranthis radix, rhizoma Polygoni Paleachi, lignum sappan, and Curcuma rhizome; the composition IV is prepared from the following raw materials in proportion: zaocys, Oletum Trogopterori, rhizoma Sparganii, Hirudo, cortex Acanthopanacis, Curcumae rhizoma, radix astragali, and Atractylodis rhizoma. The invention analyzes the pharmacological characteristics of the traditional Chinese medicine raw materials, integrates the physical function characteristics of the elderly, has scientific compatibility, fully exerts the pharmacological characteristics of the components, retains the pharmacological activity of the components for promoting blood circulation, removing blood stasis, expelling wind, removing cold, relieving swelling, easing pain and strengthening tendons and bones, can be directly orally taken, and is convenient to use.
Description
Technical Field
The invention relates to the technical field of traditional Chinese medicines, in particular to a tablet suitable for senile bone fracture and a preparation method thereof.
Background
Bone fracture diseases are clinical multiple diseases, and bone fractures are divided into soft tissue lacerations, dislocation, fractures and the like, wherein the most common diseases are fractures. Fracture is mainly caused by continuous separation or interruption of integrity and continuity of bones, and has the main symptoms of local deformation, abnormal movement of limbs and the like, bone rubbing sound audible when moving the limbs, severe pain of wounds, local swelling, soft tissue contusion, massive bleeding and the like. The aged also has a series of anatomical and physiological changes due to physiological aging, and the motor system can cause fracture and acute and chronic bone injury due to the decline of body functions and the reduction of strain capacity. With age, the body's ability to repair declines, and the resulting sequelae also increase. On the other hand, aging causes changes of body structure functions, and the changes cause changes of pharmacokinetics for the elderly, namely, changes of drug absorption, distribution, metabolism and excretion, and accordingly, the action strength and duration of the drug, even the action property of the drug can be changed to a certain extent, so that the incidence rate of adverse reactions is increased after the drug is taken by the elderly.
At present, the western medicine treatment of fracture mainly comprises a manual reduction and external fixation method, splint bandage fixation and continuous traction are used, plaster is used for fixation outside an affected part, infusion or oral antibacterial and anti-inflammatory medicines are matched, the healing capacity of the body is mainly relied on, even the internal fixation is needed to be reduced by surgical incision, and patients feel more pain in the healing process.
The traditional Chinese medicine has a long history of orthopedics and traumatology, and accumulates abundant experience in the aspect of fracture treatment. The "Nei Jing" (internal classic) records: "Qi impairment pain, form impairment and swelling". Fracture damages qi and blood, which causes blood circulation to flow through channels and blood vessels, and blood stasis, resulting in abnormal circulation of qi and blood, and pain due to swelling. The records of "the book of dialectical records of various diseases": "blood stasis can not be removed in case of blood inactivation, and blood stasis can not be connected". So it can promote blood circulation to disperse blood clots, reduce swelling and stop pain, and reunite bones and muscles.
At present, most of the traditional Chinese medicines for treating bone injuries sold in the market, which have the functions of promoting blood circulation to remove blood stasis, expelling wind and removing cold, relieving swelling and pain and strengthening tendons and bones, are plaster, and the plaster is externally applied to the bone injury to promote local blood circulation and improve the nutrition of surrounding tissues, so that the absorption of liquid in the bone is promoted, and the aims of relieving pain, diminishing inflammation, sterilizing and promoting the growth of the bone to heal are fulfilled. However, the plaster needs to be applied on the surface layer of the skin of a patient, is not easy to apply for a long time, is easy to increase the skin burden, causes skin inflammation, and especially cannot be applied by the plaster when the skin surface is damaged and ulcerated. The oral preparation is convenient and quick to take, high in effective utilization rate of medicines and wide in clinical application, but the existing oral preparation specially used for bone fracture is few in types, and the curative effect is not obvious particularly for old patients due to the problems of individual difference of patients, poor medicine absorption and the like in practical application.
Disclosure of Invention
The invention aims to provide a safe and effective pure traditional Chinese medicine preparation, which can effectively relieve the pain of patients with bone fracture, shorten the healing time and is a tablet suitable for old people bone fracture and a preparation method thereof.
The invention adopts the following technical scheme to realize the purpose, and the tablet suitable for the aged bone fracture is prepared from a first formula, a second formula, a third formula and a fourth formula, wherein the first formula is prepared from the following raw materials in proportion: 200-300 parts of codonopsis pilosula, 150-250 parts of angelica sinensis, 150-200 parts of ligusticum wallichii, 100-200 parts of pawpaw, 30-50 parts of safflower, 150-200 parts of peach kernel, 150-200 parts of green tangerine orange peel, 150-250 parts of red peony root, 100-150 parts of pseudo-ginseng, 30-50 parts of ground beetle, 150-200 parts of pollen typhae and 150-200 parts of herba lycopi; the second formula is prepared from the following raw materials in parts by weight: 150-200 parts of sargentgloryvine stem, 100-150 parts of common cephalanoplos herb, 150-250 parts of corydalis ambigua, 150-200 parts of salvia miltiorrhiza, 150-200 parts of akebia stem, 150-250 parts of tree peony bark and 150-200 parts of radix rehmanniae recen; the third formula is prepared from the following raw materials in proportion: 150-200 parts of China rose, 150-250 parts of cowherb seed, 100-150 parts of motherwort, 150-250 parts of achyranthes root, 30-60 parts of rhizoma polygoni paleacei, 100-150 parts of sappan wood and 80-120 parts of turmeric; the formula IV is prepared from the following raw materials in parts by weight: 50-100 parts of zaocys dhumnade, 100-150 parts of trogopterus dung, 100-150 parts of sambucus chinensis, 20-30 parts of leech, 100-200 parts of cortex acanthopanacis, 80-130 parts of curcuma zedoary, 100-150 parts of astragalus membranaceus and 100-150 parts of bighead atractylodes rhizome.
Preferably, the first formula of the invention is prepared from the following raw materials in parts by weight: 200 parts of codonopsis pilosula; 150 parts of angelica; 150 parts of ligusticum wallichii; 100 parts of pawpaw; 30 parts of safflower; 150 parts of peach kernel; 150 parts of green tangerine peel; 150 parts of red paeony root; 100 parts of pseudo-ginseng; 30 parts of ground beetle; 150 parts of cattail pollen; 150 parts of herba lycopi; the second formula is used for promoting blood circulation, cooling blood and relieving pain and is prepared from the following raw materials in parts by weight: 150 parts of sargentgloryvine stem; 100 parts of common cephalanoplos herb; 150 parts of rhizoma corydalis; 150 parts of salvia miltiorrhiza; 150 parts of akebia stem; 150 parts of moutan bark; 150 parts of dried rehmannia root; the third prescription is used for promoting blood circulation, removing blood stasis and reducing swelling and is prepared from the following raw materials in parts by weight: 150 parts of Chinese rose; 150 parts of cowherb seed; 100 parts of motherwort; 150 parts of achyranthes bidentata; 30 parts of rhizoma polygoni paleacei; 100 parts of sappan wood; 100 parts of turmeric; the formula IV is used for breaking blood and removing stasis, and stimulating the menstrual flow and relieving swelling, and is prepared from the following raw materials in parts by weight: 50 parts of zaocys dhumnade; 100 parts of trogopterus dung; 100 parts of three shuttles; 20 parts of leech; 100 parts of cortex acanthopanacis; 100 parts of curcuma zedoary; 100 parts of astragalus; 100 parts of bighead atractylodes rhizome.
A preparation method of a tablet suitable for senile bone fracture comprises the following steps:
the method comprises the steps of weighing raw materials of a first composition, a second composition, a third composition and a fourth composition according to the ratio requirements, crushing and pulverizing, uniformly mixing the raw materials of the compositions, sieving, fumigating and disinfecting to obtain four groups of dry powder, and storing at constant temperature for later use;
mixing four groups of dry powder obtained in the step uniformly, sieving, and removing filter residues which cannot be sieved to obtain powder which is dry, loose and uniform in color;
tabletting the raw material powder obtained in the step II to obtain the flaky tablet;
and step four, packaging and sterilizing the flaky tablets obtained in the step three to obtain finished tablets.
The sieve used for sieving in the steps of the invention is a No. 6 medicine sieve.
The fumigating and disinfecting in the steps of the invention is to fumigate the aconite leaves and the folium artemisiae argyi for 40-60 minutes.
The sieve used for sieving in the step of the invention is a No. 7 sieve.
The four components used in the invention have the following raw materials and pharmacology:
the formula I is as follows:
the radix Codonopsis is dried root of radix Codonopsis belonging to the family of cumic. Collected in autumn, washed and dried in the sun. Processing: removing impurities, cleaning, moistening, cutting, and drying. Nature and taste: sweet and neutral, has the functions of tonifying qi and spleen. Can be used for treating palpitation, asthenia, anorexia, and loose stool.
Radix Angelicae sinensis is the dry root of Angelica sinensis (oliv.) Diels of Umbelliferae, collected in late autumn, removed fibrous root and silt, bundled into small bundles after water is slightly evaporated, put on shed, and smoked slowly with firework. Processing: removing impurities from radix Angelicae sinensis, cleaning, moistening, slicing, and sun drying or low temperature drying. Property and taste: sweet, pungent and warm. The functions and indications are as follows: enriching blood, promoting blood circulation, regulating menstruation and relieving pain, and can be used for treating anemia, irregular menstruation, amenorrhea, dysmenorrhea and metrorrhagia, postpartum abdominal pain, blood deficiency constipation, traumatic injury, blood stasis pyocutaneous disease.
Rhizoma Ligustici Chuanxiong is dried rhizome of Umbelliferae plant rhizoma Ligustici Chuanxiong. In summer, when the node disc on the stem is prominent and is purple, the stem is dug, silt is removed, and the stem is dried after being dried and then fibril roots are removed. Processing: removing impurities, separating, soaking, cleaning, moistening, slicing, and drying. Nature and taste: pungent, slightly bitter and warm. The functional indications are as follows: promoting blood circulation and dredging channels, dispelling pathogenic wind and relieving pain, and can be used for treating headache, chest and hypochondriac pain, amenorrhea and abdominal pain, rheumatalgia, and traumatic injury.
The fructus Chaenomelis is dried or cooked fruit of Chaenomeles speciosa (sweet) nakai or fructus Chaenomelis (sweet) nakai of Rosa plants. The former is commonly called "wrinkled pawpaw", and the latter is commonly called "smooth-skinned pawpaw". Picking in summer and autumn when the fruit is green and yellow, scalding the wrinkled pawpaw in boiling water until the outer skin is grey white, longitudinally cutting the wrinkled pawpaw into two halves, drying the split pawpaw, longitudinally cutting the wrinkled pawpaw into two or four halves, scalding in boiling water, and drying the pawpaw. Processing: cleaning, moistening or steaming, slicing, and drying in the sun. Nature and taste: acid and warm. The functions and indications are as follows: relaxing muscles and tendons, resolving dampness, and regulating stomach function. Can be used for treating gastrocnemius spasm, abdominal pain due to vomiting and diarrhea, and rheumatic arthralgia.
The Carthami flos is dried flower of Carthamus Tinctorius of Compositae. Collected in the shade or dried in the sun when the flowers turn yellow and red in summer. Processing: the thin column head of the corolla cylinder is long and cylindrical, and the top end is slightly forked. The texture is soft. Slightly fragrant smell and slightly bitter taste. The color is red-yellow, bright-colored and soft. Nature and taste: pungent and warm. The functions and indications are as follows: promoting blood circulation, dissipating blood stasis, and dredging meridians. Can be used for treating amenorrhea, dysmenorrhea, lochiorrhea, abdominal lump, and traumatic injury.
The semen Persicae is dry mature seed of Prunus persica or Prunus davidiana of Rosaceae. Harvesting mature fruits or collecting kernels in summer and autumn, removing pulp and nucleocapsid, taking out seeds, and drying in the sun. Processing: removing impurities, boiling in boiling water until the skin is slightly wrinkled, taking out, rinsing in cold water, peeling, and sun drying. Nature and taste: bitter, sweet and neutral. The functions and indications are as follows: promote blood circulation, dispel stasis, moisten intestines. Can be used for treating amenorrhea, dysmenorrhea, abdominal lump, traumatic injury, intestinal dryness, and constipation.
The pericarpium Citri Reticulatae viride is the outer pericarp of dried young fruit or immature fruit of Citrus reticulata Blanco of Rutaceae. Picking immature fruits or collecting fallen young fruits in spring end, summer and autumn, and drying in the sun for small people, which is called as "Green Tangerine Peel"; on the larger side, the outer peel is cut into four petals, which are called "Sihua Qing Pi", and dried in the sun after removing the inner pulp. Processing: removing impurities from pericarpium Citri Reticulatae viride, cleaning, moistening, slicing or shredding, and sun drying. Parching pericarpium Citri Reticulatae viride with vinegar to slight yellow. Nature and taste: bitter, pungent and warm. The functions and indications are as follows: break qi, dissipate nodulation. Can be used for treating chest and hypochondrium distending pain, food stagnation, abdominal pain, mastitis, and hernia.
The radix Paeoniae Rubra is dried root of Ranunculaceae plant radix Paeoniae, radix Paeoniae alba or radix Paeoniae Rubra. Collected in spring and autumn, removed rhizome, fibrous root and silt, and dried in the sun. Processing: removing impurities, separating into strips, cleaning, moistening, slicing, and drying. Nature and taste: bitter and slightly cold. The functions and indications are as follows: dispel blood stasis, clear blood heat. Can be used for treating chest and hypochondrium pain, abdominal pain, conjunctival congestion, dysmenorrhea, amenorrhea, hematemesis, epistaxis, carbuncle, swelling, and traumatic injury.
Notoginseng radix is dried root of Notoginseng radix of Araliaceae. Digging before blossom in autumn, cleaning, removing rootlet, fibrous root and stem base, and drying. Processing: notoginseng radix powder is prepared by cleaning Notoginseng radix, drying, and grinding into fine powder. Cooking Notoginseng radix powder, collecting clean Notoginseng radix, crushing, dividing into small pieces, frying with edible oil until the surface turns brown yellow, taking out, and grinding into fine powder. Nature and taste: sweet, slightly bitter and warm. The functions and indications are as follows: raw product: disperse blood stasis, stop bleeding, resolve swelling and alleviate pain. Can be used for treating hemoptysis, hematemesis, thoracico-abdominal pain, metrorrhagia, traumatic injury, swelling and pain, and traumatic hemorrhage. Cooked food: to replenish and regulate blood. Can be used for treating blood loss and anemia.
The Eupolyphaga Seu Steleophaga is female dry body of Eupolyphaga Seu Steleophaga or Eupolyphaga Seu Steleophaga. Catching in summer and autumn, scalding in boiling water, and sun drying or oven drying. Nature and taste: salty and cold; has little toxicity. The functions and indications are as follows: to break blood stasis and continue the muscles and bones. Can be used for treating fracture of tendons and bones, abdominal lump, amenorrhea, blood stasis, and abdominal pain.
The pollen Typhae is dried pollen of Typha angustifolia, Typha orientalis or plants of the same genus of Typhaceae. And (4) screening pollen. Processing: breaking the lumps. Parching pollen Typhae with charcoal to brown. Nature and taste: sweet and neutral. The functional indications are as follows: stop bleeding, dispel stasis. Can be used for hemoptysis, hematemesis, and hematuria; metrorrhagia and metrostaxis, stabbing pain in the abdomen, bleeding due to trauma.
Herba Lycopi is dry aerial part of Pachyrhizus Erosi seedling of Labiatae. Collected in summer and autumn when the stem and leaf are flourishing, and dried in the sun. Processing: removing impurities, washing, moistening, cutting, and drying. Nature and taste: bitter and pungent with mild warm nature. The functions and indications are as follows: promoting blood circulation, removing blood stasis, inducing diuresis and relieving edema. Can be used for treating menoxenia, amenorrhea, edema, and puerperal abdominal pain due to blood stasis.
And the formula II comprises:
caulis Sargentodoxae is dry caulis Sargentodoxae of Lardizabalaceae. Collected in autumn and winter, removed lateral branches, cut off and dried. Processing: removing impurities, cleaning, moistening, slicing, and drying. Nature and taste: sweet and neutral. The functional indications are as follows: diminish inflammation, dispel wind and activate blood. Can be used for treating appendicitis, numbness of limbs, and soreness.
Herba Cephalanoploris is dry aerial part of Cephalanoploris or Cephalanoploris with leaf-cutting effect. Harvesting in summer and autumn, removing impurities, and sun drying. Processing: removing impurities from herba Cephalanoploris, cleaning, slightly moistening, cutting, and drying. Charring herba Cephalanoploris, and parching to dark brown. Nature and taste: sweet and cool. The functions and indications are as follows: cool blood, stop bleeding, dispel stasis. Can be used for treating nasal obstruction due to epistaxis, hematuria, and metrorrhagia; it is used externally to treat traumatic hemorrhage.
Rhizoma corydalis is dried tuber of corydalis tuber of Papaveraceae. Collected in early summer when stem and leaf withered, removed fibrous root, cleaned, boiled in boiling water until no white heart appears, taken out and dried in the sun. Processing: rhizoma corydalis: removing impurities, cleaning, drying, and mashing. Nature and taste: bitter, slightly pungent and warm. The functions and indications are as follows: promoting blood circulation, activating qi-flowing, and relieving pain. Can be used for treating chest pain, hypochondrium pain, abdominal pain, traumatic injury, pain due to blood stasis, dysmenorrhea, and puerperal abdominal pain.
The Saviae Miltiorrhizae radix is dried root and rhizome of Salvia miltiorrhiza Bunge of Labiatae. Collected in spring and autumn, removed of silt and dried. Processing: removing impurities and residual stem, cleaning, moistening, slicing, and drying. Property and taste: bitter and slightly cold. The functions and indications are as follows: dispel stasis, alleviate pain, promote blood circulation and regulate menstruation. Can be used for treating menoxenia, amenorrhea, ectopic pregnancy, hepatosplenomegaly, angina pectoris, vexation, insomnia, pyocutaneous disease, and toxic swelling.
Caulis Akebiae is dry rattan of caulis Akebiae or hydrangea vine of Ranunculaceae. Collected in spring and autumn, the rough skin is removed, and the mixture is dried in the sun, or the mixture is cut into slices while being fresh and dried in the sun. Processing: if not, slightly processed, moistened, sliced and dried in the sun. Nature and taste: bland, slightly bitter and slightly cold. The functional indications are as follows: clearing heat and promoting urination, and promoting blood circulation, and can be used for treating edema, dysuria, urinary tract infection, and joint pain.
Cortex moutan is dried root bark of Paeonia suffruticosa Andr. Digging root in autumn, removing fine root, peeling root bark, and sun drying. Processing: quickly cleaning, moistening, slicing, and drying in the sun. Nature and taste: bitter, pungent and slightly cold. The functions and indications are as follows: clear blood heat and dissipate blood stasis. Can be used for treating pyretic macula, rash, hematemesis, epistaxis, hectic fever, dysmenorrhea, amenorrhea, and carbuncle.
Radix rehmanniae is fresh or dried root tuber of rehmannia glutinosa Libosch of Scrophulariaceae. Collected in autumn, removed the reed heads and fibrous roots, washed, and the fresh one is called as "fresh rehmannia root"; fresh rehmannia root is slowly baked to about eight dry ingredients, and then kneaded into a mass, which is called as 'rehmannia root'. Processing: removing impurities from radix rehmanniae, cleaning, moistening, slicing, and drying. Charring the root of rehmannia: parching radix rehmanniae tablet with parching charcoal until it foams and swells. Prepared rehmannia root: collecting clean radix rehmanniae, soaking in yellow wine , taking out, sun drying until the mucus on the outer skin is slightly dry, slicing, and sun drying. 100kg of radix rehmanniae is treated with 50kg of yellow wine. (2) Steaming clean radix rehmanniae to black, taking out, sun drying to about eighty percent dry, slicing, and sun drying. Nature and taste: fresh rehmannia root, radix rehmanniae is sweet and cold. Radix rehmanniae: sweet and cold in nature. Prepared rehmannia root: sweet, slightly bitter and warm. The functions and indications are as follows: fresh rehmannia root: clear heat, cool blood and promote fluid production. Can be used for treating excessive heat in febrile disease, dysphoria, thirst, macula, eruption, hematemesis, epistaxis, hematuria, and sore throat. Radix rehmanniae: to nourish yin, clear heat, cool blood and stop bleeding. Can be used for treating fever dysphoria, macula, eruption, yin deficiency, low grade fever, diabetes, hematemesis, epistaxis, hematuria, and metrorrhagia. Prepared rehmannia root, radix rehmanniae Praeparata has the effects of nourishing yin and enriching blood. Can be used for treating yin deficiency, blood deficiency, blurred vision, tinnitus, soreness of waist and knees, diabetes, spermatorrhea, amenorrhea, metrorrhagia, and metrostaxis.
The formula III is as follows:
the flos Rosae chinensis is dried flower of Rosa chinensis of Rosaceae. All the flowers can be collected all the year round, and the flowers are picked when the flowers are slightly bloomed, and dried in the shade or at low temperature. Processing: drying flos Rosae chinensis in the shade or at low temperature. The whole, purple red and fragrant smell is preferred. Nature and taste: sweet and warm. The functions and indications are as follows: promoting blood circulation to regulate menstruation. Can be used for treating menoxenia and dysmenorrhea.
The semen Vaccariae is dried mature seed of Vaccaria segetalis (L.) Garcke of Caryophyllaceae. Collecting plants when fruits are mature and fruit peel is not cracked in summer, drying in the sun, seeding, removing impurities, and drying in the sun. The characteristics are as follows: the product is spherical and has a diameter of about 2 mm. The surface is black, a few of the surfaces are reddish brown and have slight luster, fine granular protrusions are arranged, and one side of each surface is provided with a 1-dent longitudinal groove. Hard, white endosperm can be seen after breaking open, the embryo is bent into rings, 2 cotyledons are not smelly, and the taste is slightly astringent and bitter. Preferably, the grains are full and black. Processing: removing impurities, and parching until most of them are bloomed to white flower. Nature and taste: bitter and neutral. The functions and indications are as follows: promoting blood circulation and dredging channels, promoting lactation and relieving swelling, and can be used for treating galactostasis, amenorrhea due to blood stasis, and carbuncle and swelling.
Herba Leonuri is dry aerial part of herba Leonuri of Labiatae. Harvesting stems and leaves of the second season when the flowers are flourishing, and sun-drying or cutting and sun-drying. Processing: removing impurities, quickly cleaning, moistening, cutting, and drying. Nature and taste: bitter, pungent and slightly cold. The functional indications are as follows: promoting blood circulation to regulate menstruation, inducing diuresis to alleviate edema. Can be used for treating menoxenia and dysmenorrhea. Amenorrhea, persistent lochiorrhea, edema due to acute nephritis.
Achyranthis radix is dried root of Achyranthis radix of Amaranthaceae. Digging when stem and leaf wither in winter, removing fibrous root and silt, bundling into small bundle, drying to dry wrinkle, fumigating with sulfur for 2 times, cutting top end, and drying in the sun. Processing: removing impurities, cleaning, moistening, removing residual rhizoma Phragmitis, cutting into segments, and sun drying. Nature and taste: bitter, sour and neutral. The functions and indications are as follows: tonify liver and kidney, strengthen tendons and bones, promote blood circulation and lower blood pressure. Can be used for treating soreness of waist and knees, spasm of lower limbs, amenorrhea, and hypertension.
Rhizoma Polygoni Paleachi is dried rhizome of rhizoma Polygoni Paleachi of Polygonaceae. Collected in autumn, removed fibrous root and muddy water, and dried. Processing: removing impurities, slightly soaking, cleaning, moistening, slicing, and sun drying. Nature and taste: bitter, astringent and slightly warm. The functions and indications are as follows: removing blood stasis, regulating menstruation, stopping bleeding, and promoting digestion. Can be used for treating traumatic injury, amenorrhea due to blood stasis, dyspepsia, and gastralgia; it is used externally to treat traumatic hemorrhage.
Lignum sappan is dried heartwood of lignum sappan of Leguminosae. When the harvesting is more than autumn harvesting, white sapwood is removed and dried. Processing: the pieces are cut into pieces according to the length of about 3 cm. Nature and taste: sweet, salty and neutral. The functions and indications are as follows: promote blood circulation to remove blood stasis, relieve swelling and alleviate pain. Can be used for treating chest and abdominal pain, amenorrhea, puerperal blood stasis and distending pain, and traumatic hematoma.
The Curcuma rhizome is dried rhizome of Curcuma rhizome of Zingiberaceae. Collected in winter when stem and leaf withered, cleaned, boiled or steamed until the core is penetrated, dried in the sun, and the fibrous root is removed. Processing: removing impurities, slightly soaking, cleaning, moistening, slicing, and sun drying. Nature and taste: pungent, bitter and warm. Functions and indications: break blood, move qi and alleviate pain. Can be used for treating stabbing pain in chest and hypochondrium, amenorrhea, abdominal lump, traumatic injury, swelling and pain, and carbuncle.
The formula is four:
zaocys, also known as black-striped snake and black snake, is dried body of Zaocys dhumnades of Colubridae with viscera removed. Collecting more than in summer and autumn, cutting open abdomen or peeling skin of snake, removing viscera, making into disc, and drying. Dispel wind, unblock collaterals, stop convulsions. Nature and taste: sweet and neutral. Can be used for treating rheumatism, numbness, spasm, facial distortion, hemiplegia, convulsion, tetanus, leprosy, scabies, and lymphoid tuberculosis.
Trogopterus dung is dry feces of compound-tooth squirrel of the family Trogopterus. Collected all the year round, removed impurities and dried in the sun. It is divided into "Lingzhi block" and "Lingzhi rice" according to the difference of appearance. Processing: trogopterus dung: removing impurities, and smashing into small pieces. Vinegar trogopterus dung: parching Oletum Trogopterori with vinegar to slightly dry. Nature and taste: bitter and warm. The functions and indications are as follows: promoting blood circulation, removing blood stasis and relieving pain. Can be used for treating chest pain, abdominal pain, dysmenorrhea, amenorrhea, and puerperal pain due to blood stasis. Traumatic injury, snake and insect bite.
The three-shuttle is a dried tuber of black-shuttle plant. Processing: and (3) removing impurities, soaking, moistening, slicing and drying. Nature and taste: bitter and neutral. The functions and indications are as follows: break blood, move qi, remove food retention, alleviate pain, and can be used for abdominal pain, abdominal mass, and hepatosplenomegaly.
The Hirudo is dried body of Whitmania pigra Whitman, Whitmania acranulata Whitman or Hirudo Whitmania pigra Whitman of Hirudinidae. Catching in summer and autumn, scalding with boiling water, and sun drying or drying at low temperature. Processing: cleaning Hirudo, cutting into pieces, and drying. And (3) leech preparation: parching Hirudo with pulvis Talci by scalding until it is slightly swollen. Nature and taste: salty, bitter and neutral; is toxic. The functions and indications are as follows: to break blood stasis and dredge meridians. Can be used for treating abdominal lump and amenorrhea due to blood stasis.
Cortex Acanthopanacis is the dried root bark of Acanthopanax gracilistylus W.W.W.W.Chen of Araliaceae. Root control in summer and autumn, and sun drying. Processing: removing impurities, cleaning, moistening, cutting, and drying in the sun. Nature and taste: pungent, bitter and warm. The functions and indications are as follows: dispel wind-damp, strengthen tendons and bones, and tonify qi. Can be used for treating wind-cold-dampness, joint pain, limb spasm, weakness of waist and knee, infantile withdrawal, and asthenia.
The Curcumae rhizoma is dried rhizome of Curcuma zedoaria Roscoe, Curcuma aromatica Salisb or Curcuma kwangsiensis Salisb of Zingiberaceae. Collecting stems and leaves after withering in winter, cleaning, steaming or decocting until they are thoroughly transparent, drying, and removing fibrous root and impurities. Processing: zedoary turmeric: removing impurities, soaking, cleaning, moistening, slicing, and drying. Vinegar processed curcuma zedoary: soaking clean Curcumae rhizoma in vinegar by decocting with vinegar, decocting until the vinegar is thoroughly soaked, taking out, slightly drying, slicing, and drying. Nature and taste: bitter, pungent and warm. The functions and indications are as follows: move qi and break blood stasis, remove food retention and alleviate pain. Can be used for treating abdominal lump, stagnation, distending pain, amenorrhea due to blood stasis, and traumatic injury.
Radix astragali is dried root of Leguminosae plant such as Hemerocallis citrina baroni, Hemerocallis citrina baroni or Hemerocallis polybracteata. The former two are called "Huangqi", the latter are called "papua", collected in spring and autumn, removed the roots and heads, and dried in the sun. Processing: removing impurities from radix astragali, cleaning, moistening, slicing, and sun drying. Honey radix astragali is prepared by taking HUANGHUA tablet, parching with dense water to yellow according to dense charcoal method, and cleaning without sticking to hand. Nature and taste: sweet and warm. The functions and indications are as follows: tonify qi, strengthen superficies, induce diuresis, expel toxin, expel pus and promote tissue regeneration. Shortness of breath, palpitation, collapse, spontaneous sweating, edema due to asthenia, chronic nephritis, chronic diarrhea, unhealed sore, etc.
Atractylodis rhizoma is dried rhizome of Atractylodes macrocephala Koidz of Compositae. In winter, the lower leaves are withered and yellow, and the upper leaves are picked and dug when becoming brittle, and then the silt is removed, dried or dried in the sun, and the fibrous roots are removed. Processing: white atractylodes rhizome: removing impurities, cleaning, moistening, slicing, and drying. Frying the bighead atractylodes rhizome: parching Atractylodis rhizoma tablet with bran until color turns dark. Nature and taste: sweet, bitter and warm. The functions and indications are as follows: strengthen spleen and dry dampness. Can be used for treating spleen deficiency, anorexia, abdominal distention, diarrhea, phlegm retention, vertigo, edema, and threatened abortion.
The invention analyzes the pharmacological characteristics of the traditional Chinese medicine raw materials, integrates the characteristics of the decline of the body functions, the reduction of the strain capacity, the increase of acute and chronic injuries, the reduction of the repair capacity and the increase of sequelae of the old people, carries out scientific compatibility, gives full play to the pharmacological characteristics of each component, adopts the processing technology of extrusion tabletting and fully retains the pharmacological activity of each component for promoting blood circulation to remove blood stasis, expelling wind and removing cold, relieving swelling and pain and strengthening tendons and bones.
By adopting the technical scheme, the invention better realizes the purpose of the invention, adopts pure traditional Chinese medicine products as raw materials, has reasonable formula and combined medicines, can promote blood circulation to remove blood stasis, relieve swelling and pain, can be directly orally taken when patients suffer from bone fracture, and is convenient and fast to use. The invention adopts natural aconite leaf and argy wormwood leaf to fumigate and disinfect the raw material components, changes the manufacturing method of sulfur fumigation commonly used in the industry, and is safer and healthier.
Detailed Description
The present invention will be further described with reference to the following examples.
Example 1:
the tablet is prepared from a first formula, a second formula, a third formula and a fourth formula, wherein the first formula is used for removing blood stasis, stopping bleeding, relieving swelling and pain and is prepared from the following raw materials in parts by weight: 200 parts of codonopsis pilosula; 150 parts of angelica; 150 parts of ligusticum wallichii; 100 parts of pawpaw; 30 parts of safflower; 150 parts of peach kernel; 150 parts of green tangerine peel; 150 parts of red paeony root; 100 parts of pseudo-ginseng; 30 parts of ground beetle; 150 parts of cattail pollen; 150 parts of herba lycopi; the second prescription is used for promoting blood circulation, cooling blood and relieving pain and is prepared from the following raw materials in parts by weight: 150 parts of sargentgloryvine stem; 100 parts of common cephalanoplos herb; 150 parts of rhizoma corydalis; 150 parts of salvia miltiorrhiza; 150 parts of akebia stem; 150 parts of moutan bark; 150 parts of dried rehmannia root; the third prescription is used for promoting blood circulation, removing blood stasis and reducing swelling and is prepared from the following raw materials in parts by weight: 150 parts of Chinese rose; 150 parts of cowherb seed; 100 parts of motherwort; 150 parts of achyranthes bidentata; 30 parts of rhizoma polygoni paleacei; 100 parts of sappan wood; 100 parts of turmeric; the formula IV is used for breaking blood and removing stasis, and stimulating the menstrual flow and relieving swelling, and is prepared from the following raw materials in parts by weight: 50 parts of zaocys dhumnade; 100 parts of trogopterus dung; 100 parts of three shuttles; 20 parts of leech; 100 parts of cortex acanthopanacis; 100 parts of curcuma zedoary; 100 parts of astragalus; 100 parts of bighead atractylodes rhizome.
A preparation method of a tablet suitable for senile bone fracture comprises the following steps:
the method comprises the steps of weighing raw materials of a first composition, a second composition, a third composition and a fourth composition according to the ratio requirements, crushing and pulverizing, uniformly mixing the raw materials of the compositions, sieving, fumigating and disinfecting to obtain four groups of dry powder, and storing at constant temperature for later use;
mixing four groups of dry powder obtained in the step uniformly, sieving, and removing filter residues which cannot be sieved to obtain powder which is dry, loose and uniform in color;
tabletting the raw material powder obtained in the step II, wherein each tablet is 0.35g, and then obtaining the flaky tablet;
and fourthly, packaging the flaky tablets obtained in the step three by using plastic bottles, and sterilizing 260 tablets in each bottle to obtain finished tablets.
The sieve used for sieving in the step is a No. 6 medicine sieve.
The fumigating and sterilizing step is to use the aconite leaves and the folium artemisiae argyi to fumigate and sterilize for 40-60 minutes at 120 ℃.
The sieve used for sieving in the step II is a No. 7 sieve.
Example 2:
the tablet is prepared from a first formula, a second formula, a third formula and a fourth formula, wherein the first formula is prepared from the following raw materials in parts by weight: 200 parts of codonopsis pilosula; 150 parts of angelica; 150 parts of ligusticum wallichii; 100 parts of pawpaw; 30 parts of safflower; 150 parts of peach kernel; 150 parts of green tangerine peel; 150 parts of red paeony root; 100 parts of pseudo-ginseng; 30 parts of ground beetle; 150 parts of cattail pollen; 150 parts of herba lycopi; the second formula is used for promoting blood circulation, cooling blood and relieving pain and is prepared from the following raw materials in parts by weight: 150 parts of sargentgloryvine stem; 100 parts of common cephalanoplos herb; 150 parts of rhizoma corydalis; 150 parts of salvia miltiorrhiza; 150 parts of akebia stem; 150 parts of moutan bark; 150 parts of dried rehmannia root; the third prescription is used for promoting blood circulation, removing blood stasis and reducing swelling and is prepared from the following raw materials in parts by weight: 150 parts of Chinese rose; 150 parts of cowherb seed; 100 parts of motherwort; 150 parts of achyranthes bidentata; 30 parts of rhizoma polygoni paleacei; 100 parts of sappan wood; 100 parts of turmeric; the formula IV is used for breaking blood and removing stasis, and stimulating the menstrual flow and relieving swelling, and is prepared from the following raw materials in parts by weight: 50 parts of zaocys dhumnade; 100 parts of trogopterus dung; 100 parts of three shuttles; 20 parts of leech; 100 parts of cortex acanthopanacis; 100 parts of curcuma zedoary; 100 parts of astragalus; 100 parts of bighead atractylodes rhizome.
The same as in example 1.
Example 3:
the tablet is prepared from a first formula, a second formula, a third formula and a fourth formula, wherein the first formula is prepared from the following raw materials in parts by weight: 300 parts of codonopsis pilosula; 250 parts of Chinese angelica; 200 parts of ligusticum wallichii; 200 parts of pawpaw; 50 parts of safflower; 200 parts of peach kernel; 200 parts of green tangerine peel; 250 parts of red peony root; 150 parts of pseudo-ginseng; 50 parts of ground beetle; 200 parts of cattail pollen; 200 parts of herba lycopi; the second formula is used for promoting blood circulation, cooling blood and relieving pain and is prepared from the following raw materials in parts by weight: 200 parts of sargentgloryvine stem; 150 parts of common cephalanoplos herb; 250 parts of rhizoma corydalis; 200 parts of salvia miltiorrhiza; 200 parts of akebia stem; 250 parts of tree peony bark; 200 parts of dried rehmannia root; the third prescription is used for promoting blood circulation, removing blood stasis and reducing swelling and is prepared from the following raw materials in parts by weight: 200 parts of Chinese rose; 250 parts of cowherb seed; 150 parts of motherwort; 250 parts of achyranthes bidentata; 60 parts of rhizoma polygoni paleacei; 150 parts of sappan wood; 150 parts of turmeric; the formula IV is used for breaking blood and removing stasis, and stimulating the menstrual flow and relieving swelling, and is prepared from the following raw materials in parts by weight: 100 parts of zaocys dhumnade; 150 parts of trogopterus dung; 150 parts of three shuttles; 30 parts of leech; 200 parts of cortex acanthopanacis; 130 parts of curcuma zedoary; 150 parts of astragalus; 150 parts of bighead atractylodes rhizome.
The same as in example 1.
Clinical trial
Experimental example 1
Selecting 800 old bone fracture patients, selecting the finished product tablets prepared in the embodiment 1 to carry out clinical experimental research, wherein the age bracket of the old people in China is (1) 110 old patients in the early stage of the old people in 110 cases, wherein 50 male patients and 60 female patients are selected from the 800 patients; (2) 200 cases of 60-75 years old patients in total, wherein 80 cases of male patients and 120 cases of female patients are included; (3) 490 patients of 76-85 years old age, 200 male and 290 female. 800 patients were classified according to trauma, including: 480 cases of soft tissue injuries, 180 cases of double ankle fractures and 140 cases of joint dislocation and subluxation. Patient trauma description: wherein the soft tissue injury site includes: wounds of four limbs, two lower limbs, the waist and the back and the like; the double ankle fracture comprises: fracture of medial malleolus and lateral malleolus, dislocation of joint, dislocation of hip joint; the joint dislocation and subluxation are knee joint dislocation and subluxation.
The medicine is taken according to the trauma classification of patients, and the average medicine is calculated, wherein the medicine is taken for 90 days for soft tissue injury, 110 days for double ankle fracture, and 88 days for joint dislocation or subluxation. The medicine is used for patients with double ankle fracture and joint dislocation after manual reduction.
After the medicine is taken, the function recovery condition of the patient is observed and analyzed, and the medicine taking effect is evaluated according to the function recovery evaluation standard, wherein the evaluation standard comprises a good effect and a poor effect, and the evaluation standard comprises the following steps: (1) good: firstly, local swelling disappears, and no red swelling tenderness exists; the fracture alignment of the X-ray film is good, the callus grows well, and fracture lines basically disappear; the joints move freely and can walk normally; (2) difference: firstly, the local part is slightly red and swollen and tenderness; the fracture alignment on the X-ray film is good, the callus grows slowly, and the fracture line is visible; the joints move and have pain when walking.
TABLE 1 Observation and analysis of curative effects of bone fracture diseases in elderly
The results of the patient taking the medicine are tracked, and the detailed results are shown in table 1 according to the function recovery evaluation criteria, wherein the results show that (1) the good cases of 480 patients with soft tissue injury comprise 475 cases, 98.9 percent of the patients, and the poor cases comprise 5 cases, 1.1 percent of the patients; (2) among 180 cases of double ankle fracture, 175 cases of fracture are good, accounting for 97.2 percent, and 5 cases of fracture are poor, accounting for 2.8 percent; (3) among 140 patients with joint dislocation, 128 patients with joint dislocation are good, accounting for 91.4%, and 12 patients with joint dislocation account for 8.6%. From the above data, it is known that the overall functional recovery rate is 97.25% and the difference is 2.75% among 800 patients, showing that taking the traditional Chinese medicine tablet of the present invention has an excellent healing effect on bone injuries of elderly patients.
TABLE 2 analysis of age groups of bone fracture diseases of the elderly and effective rate of treatment
Further analysis, the treatment effect was analyzed and evaluated according to the age groups of the middle aged and elderly people with 800 patients, and the treatment effect was classified into significant effect (significant effect), effective effect and ineffective effect according to the effect after administration, which is detailed in table 2. As can be seen from table 2, (1) among 110 patients in the early stage of the elderly, 102 patients had significant effect, accounting for 92.7%; 5 effective cases account for 4.6 percent; invalid 3 cases account for 2.7 percent; (2) 185 patients in 200 patients in the old age period have obvious effect; the proportion is 92.5 percent, the effective proportion is 10 cases, and the proportion is 5 percent; 5 cases of invalidity, 2.5 percent of occupation; (3) among 490 cases in the elderly, 400 cases with obvious effect account for 81.63%; 80 effective cases account for 16.33 percent; the effective 10 cases account for 2.0 percent; (4) in 800 patients, 687 cases of significant effect, 85.87% of the proportion, 95 cases of effect, 11.88% of the proportion and 18 cases of no effect, 2.25% of the proportion.
The experimental results show that the old has weakened metabolism and low organ function of the whole body, and the old can hurt the functions of qi, blood and organs better than the young after the trauma. Due to traumatic blood loss, pain and irritation, limited activity, its hemodynamics, and the functions of heart, lung and kidney must be affected. In the book of Ming Dynasty Xue' Zheng Liang Feng Liang, the injury of qi and blood to the inside, incoherence of ying and wei and incoherence of zang-fu organs, the local bone injury has been explained.
Test example 2
656 patients with soft tissue injuries, double ankle fractures and joint dislocation and subluxation of old people with the age of 60-80 years are selected, and the finished product medicine prepared in the embodiment 3 is selected to carry out clinical experimental research. Adopting random distribution principle, dividing into 328 cases of test group and control group, wherein 222 cases of soft tissue injury, 58 cases of double ankle fracture, 48 cases of joint dislocation and subluxation, and using medicine after manual reduction. The test group takes the finished product tablets prepared in the embodiment 3 of the invention 3 tablets each time, 3 times a day, 1 month is a treatment course, and 2-3 months are continued; the control group takes compound Saviae Miltiorrhizae radix tablet 3 tablets each time, 3 times daily, 1 month as a treatment course, 2-3 months continuously.
According to the condition after the medicine is taken by a case, the patient is evaluated, and the evaluation indexes comprise: (1) local swelling and tenderness do not exist; (2) x-ray films showed fuzzy fracture lines with continuous callus passage; (3) the joint movement is good, and the local part has no red swelling and tenderness; (4) the fracture and the joint dislocation have no abnormal change after 6 months of follow-up; (5) the function is recovered, swelling and tenderness do not exist at a plurality of soft tissue injury positions of a patient, and the movement and the healthy side of the ankle joint and each dislocation joint are the same or basically the same. The curative conditions of patients are evaluated as excellent, good and poor respectively by integrating the effect of each index.
TABLE 3 clinical experimental study of the Chinese medicinal tablet for treating senile bone injury and the compound Danshen tablet
The treatment effect evaluation indexes are used for evaluating and recording the medication effect of patients, the details are shown in table 3, and the results show that in 328 patients in 222 patients with soft tissue injury treatment of the patients: 211 cases are superior, 5 cases are good, and 6 cases are poor, and of 58 cases with double ankle fracture, 48 cases are superior, 8 cases are good, and 2 cases are poor; of 48 patients with joint dislocation and subluxation, the superior case is 45, the good case is 2 and the poor case is 1; in 328 patients in the control group, the soft tissue injuries are superior 186 cases, superior 24 cases and inferior 12 cases; 40 cases, 12 cases and 6 cases of double ankle fracture, 48 cases of joint dislocation and subluxation, 38 cases and 5 cases of joint dislocation and poor fracture.
As can be seen from Table 3, in test group 328 of the present invention: 319 cases are cured, wherein 304 cases account for 92.68% in the superior case, 15 cases account for 4.57% in the superior case, and 2.75% in the poor case; in control 328: 272 cases are cured, wherein 264 cases account for 80.49 percent, 41 cases account for 12.5 percent and 23 cases account for 7.01 percent. The test data show that the two different treatment schemes are compared, the cure rate of the treatment scheme of the test group is obviously higher than that of the control group, and the difference of the two groups of administration effects is obvious, which shows that the traditional Chinese medicine tablet of the invention has obvious effect on the healing of bone injuries such as soft tissue injury, double ankle fracture, joint dislocation and the like.
The invention analyzes the pharmacological characteristics of each raw material, carries out scientific compatibility according to the bone fracture diseases and the characteristics of the functions of the old, fully exerts the pharmacological characteristics of each component, adopts the processing technology of extrusion tablets, and fully retains the pharmacological activity of each component for promoting blood circulation, removing blood stasis, reducing swelling and relieving pain. Has obvious effect on healing bone injuries such as soft tissue injury, fracture, joint dislocation combined with soft tissue injury and the like. The medicine can be directly taken orally after bone injury of patients, and is convenient to use. The invention cancels the process mode of sulfur fumigation, utilizes two toxic medicinal materials of folium artemisiae argyi and radix aconiti szechenyiani and the special functions, plays a role in good disinfection and prevention of denaturation and vitamin pollution, protects the original physical properties of the traditional Chinese medicine tablet from being influenced, and is more beneficial to the clinical efficacy of the tablet.
Claims (6)
1. The tablet suitable for the bone fracture of the old is characterized by being prepared from a first formula, a second formula, a third formula and a fourth formula, wherein the first formula is prepared from the following raw materials in parts by weight: 200-300 parts of codonopsis pilosula, 150-250 parts of angelica sinensis, 150-200 parts of ligusticum wallichii, 100-200 parts of pawpaw, 30-50 parts of safflower, 150-200 parts of peach kernel, 150-200 parts of green tangerine orange peel, 150-250 parts of red peony root, 100-150 parts of pseudo-ginseng, 30-50 parts of ground beetle, 150-200 parts of pollen typhae and 150-200 parts of herba lycopi; the second formula is prepared from the following raw materials in parts by weight: 150-200 parts of sargentgloryvine stem, 100-150 parts of common cephalanoplos herb, 150-250 parts of corydalis ambigua, 150-200 parts of salvia miltiorrhiza, 150-200 parts of akebia stem, 150-250 parts of tree peony bark and 150-200 parts of radix rehmanniae recen; the third formula is prepared from the following raw materials in proportion: 150-200 parts of China rose, 150-250 parts of cowherb seed, 100-150 parts of motherwort, 150-250 parts of achyranthes root, 30-60 parts of rhizoma polygoni paleacei, 100-150 parts of sappan wood and 80-120 parts of turmeric; the formula IV is prepared from the following raw materials in parts by weight: 50-100 parts of zaocys dhumnade, 100-150 parts of trogopterus dung, 100-150 parts of sambucus chinensis, 20-30 parts of leech, 100-200 parts of cortex acanthopanacis, 80-130 parts of curcuma zedoary, 100-150 parts of astragalus membranaceus and 100-150 parts of bighead atractylodes rhizome.
2. The tablet suitable for senile bone fracture according to claim 1, wherein the first formula is prepared from the following raw materials in parts by weight: the first formula is prepared from the following raw materials in parts by weight: 200 parts of codonopsis pilosula; 150 parts of angelica; 150 parts of ligusticum wallichii; 100 parts of pawpaw; 30 parts of safflower; 150 parts of peach kernel; 150 parts of green tangerine peel; 150 parts of red paeony root; 100 parts of pseudo-ginseng; 30 parts of ground beetle; 150 parts of cattail pollen; 150 parts of herba lycopi; the second formula is used for promoting blood circulation, cooling blood and relieving pain and is prepared from the following raw materials in parts by weight: 150 parts of sargentgloryvine stem; 100 parts of common cephalanoplos herb; 150 parts of rhizoma corydalis; 150 parts of salvia miltiorrhiza; 150 parts of akebia stem; 150 parts of moutan bark; 150 parts of dried rehmannia root; the third prescription is used for promoting blood circulation, removing blood stasis and reducing swelling and is prepared from the following raw materials in parts by weight: 150 parts of Chinese rose; 150 parts of cowherb seed; 100 parts of motherwort; 150 parts of achyranthes bidentata; 30 parts of rhizoma polygoni paleacei; 100 parts of sappan wood; 100 parts of turmeric; the formula IV is used for breaking blood and removing stasis, and stimulating the menstrual flow and relieving swelling, and is prepared from the following raw materials in parts by weight: 50 parts of zaocys dhumnade; 100 parts of trogopterus dung; 100 parts of three shuttles; 20 parts of leech; 100 parts of cortex acanthopanacis; 100 parts of curcuma zedoary; 100 parts of astragalus; 100 parts of bighead atractylodes rhizome.
3. A preparation method of a tablet suitable for senile bone fracture is characterized by comprising the following steps:
the method comprises the steps of weighing raw materials of a first composition, a second composition, a third composition and a fourth composition according to the ratio requirements, crushing and pulverizing, uniformly mixing the raw materials of the compositions, sieving, fumigating and disinfecting to obtain four groups of dry powder, and storing at constant temperature for later use;
mixing four groups of dry powder obtained in the step uniformly, sieving, and removing filter residues which cannot be sieved to obtain powder which is dry, loose and uniform in color;
tabletting the raw material powder obtained in the step II to obtain a flaky tablet;
and step four, packaging and sterilizing the flaky tablets obtained in the step three to obtain finished tablets.
4. The method for preparing a tablet suitable for senile bone fracture according to claim 3, characterized in that the sieve used for sieving in the step is a No. 6 medicine sieve.
5. The preparation method of the tablet suitable for the senile bone fracture according to claim 3, characterized in that fumigation in the step is carried out by fumigating aconite leaves and folium artemisiae argyi for 40-60 minutes.
6. The method for preparing the tablet suitable for the bone fracture of the elderly as claimed in claim 3, wherein the sieve used for sieving in the step II is No. 7 sieve.
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106983839A (en) * | 2017-04-01 | 2017-07-28 | 梁风岐 | A kind of medicine of swelling and pain relieving promoting blood circulation and removing blood stasis and application thereof |
| CN107854614A (en) * | 2017-12-04 | 2018-03-30 | 曹建中 | It is a kind of to be used to treat powder of soft tissue injury and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106983839A (en) * | 2017-04-01 | 2017-07-28 | 梁风岐 | A kind of medicine of swelling and pain relieving promoting blood circulation and removing blood stasis and application thereof |
| CN107854614A (en) * | 2017-12-04 | 2018-03-30 | 曹建中 | It is a kind of to be used to treat powder of soft tissue injury and preparation method thereof |
Non-Patent Citations (1)
| Title |
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| 余林涛: "血府逐瘀活血汤加减治疗软组织损伤60例" * |
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