CN114668012B - Sterilization composition containing picolinamide and tebuconazole and application thereof - Google Patents
Sterilization composition containing picolinamide and tebuconazole and application thereof Download PDFInfo
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- CN114668012B CN114668012B CN202210320001.9A CN202210320001A CN114668012B CN 114668012 B CN114668012 B CN 114668012B CN 202210320001 A CN202210320001 A CN 202210320001A CN 114668012 B CN114668012 B CN 114668012B
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- tebuconazole
- picolinamide
- pesticide
- bactericidal
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- 239000005839 Tebuconazole Substances 0.000 title claims abstract description 100
- PXMNMQRDXWABCY-UHFFFAOYSA-N 1-(4-chlorophenyl)-4,4-dimethyl-3-(1H-1,2,4-triazol-1-ylmethyl)pentan-3-ol Chemical compound C1=NC=NN1CC(O)(C(C)(C)C)CCC1=CC=C(Cl)C=C1 PXMNMQRDXWABCY-UHFFFAOYSA-N 0.000 title claims abstract description 97
- IBBMAWULFFBRKK-UHFFFAOYSA-N picolinamide Chemical compound NC(=O)C1=CC=CC=N1 IBBMAWULFFBRKK-UHFFFAOYSA-N 0.000 title claims abstract description 83
- 239000000203 mixture Substances 0.000 title claims abstract description 40
- 230000001954 sterilising effect Effects 0.000 title claims description 8
- 238000004659 sterilization and disinfection Methods 0.000 title claims description 8
- 230000000844 anti-bacterial effect Effects 0.000 claims abstract description 46
- 239000000575 pesticide Substances 0.000 claims abstract description 25
- 240000008042 Zea mays Species 0.000 claims abstract description 18
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 claims abstract description 18
- 235000002017 Zea mays subsp mays Nutrition 0.000 claims abstract description 18
- 235000005822 corn Nutrition 0.000 claims abstract description 18
- 238000002360 preparation method Methods 0.000 claims abstract description 15
- 240000008067 Cucumis sativus Species 0.000 claims description 19
- 235000010799 Cucumis sativus var sativus Nutrition 0.000 claims description 19
- 241000233679 Peronosporaceae Species 0.000 claims description 18
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- 238000000576 coating method Methods 0.000 claims description 3
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- 230000000855 fungicidal effect Effects 0.000 claims description 3
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- 239000003899 bactericide agent Substances 0.000 description 9
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- 241000221785 Erysiphales Species 0.000 description 6
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- FFXNQICQXPTWGP-UHFFFAOYSA-N 2-methyl-1,2-dihydropyridine Chemical compound CC1NC=CC=C1 FFXNQICQXPTWGP-UHFFFAOYSA-N 0.000 description 3
- 241000196324 Embryophyta Species 0.000 description 3
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 3
- 206010039509 Scab Diseases 0.000 description 3
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 3
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- YDEXUEFDPVHGHE-GGMCWBHBSA-L disodium;(2r)-3-(2-hydroxy-3-methoxyphenyl)-2-[2-methoxy-4-(3-sulfonatopropyl)phenoxy]propane-1-sulfonate Chemical compound [Na+].[Na+].COC1=CC=CC(C[C@H](CS([O-])(=O)=O)OC=2C(=CC(CCCS([O-])(=O)=O)=CC=2)OC)=C1O YDEXUEFDPVHGHE-GGMCWBHBSA-L 0.000 description 3
- NVVZQXQBYZPMLJ-UHFFFAOYSA-N formaldehyde;naphthalene-1-sulfonic acid Chemical compound O=C.C1=CC=C2C(S(=O)(=O)O)=CC=CC2=C1 NVVZQXQBYZPMLJ-UHFFFAOYSA-N 0.000 description 3
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 3
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- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 description 3
- 230000001018 virulence Effects 0.000 description 3
- 235000017060 Arachis glabrata Nutrition 0.000 description 2
- 235000010777 Arachis hypogaea Nutrition 0.000 description 2
- 235000018262 Arachis monticola Nutrition 0.000 description 2
- 241001465180 Botrytis Species 0.000 description 2
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
- XDTMQSROBMDMFD-UHFFFAOYSA-N Cyclohexane Chemical compound C1CCCCC1 XDTMQSROBMDMFD-UHFFFAOYSA-N 0.000 description 2
- 208000035240 Disease Resistance Diseases 0.000 description 2
- CTQNGGLPUBDAKN-UHFFFAOYSA-N O-Xylene Chemical compound CC1=CC=CC=C1C CTQNGGLPUBDAKN-UHFFFAOYSA-N 0.000 description 2
- 239000002202 Polyethylene glycol Substances 0.000 description 2
- 241001281805 Pseudoperonospora cubensis Species 0.000 description 2
- 235000014443 Pyrus communis Nutrition 0.000 description 2
- 241001533598 Septoria Species 0.000 description 2
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- 239000007798 antifreeze agent Substances 0.000 description 2
- 239000006229 carbon black Substances 0.000 description 2
- 235000013339 cereals Nutrition 0.000 description 2
- ATZHVIVDMUCBEY-HOTGVXAUSA-N florylpicoxamid Chemical compound C(C)(=O)OC=1C(=NC=CC=1OC)C(=O)N[C@H](C(=O)O[C@H](C(C1=CC=C(C=C1)F)C1=CC=C(C=C1)F)C)C ATZHVIVDMUCBEY-HOTGVXAUSA-N 0.000 description 2
- 230000009036 growth inhibition Effects 0.000 description 2
- JEIPFZHSYJVQDO-UHFFFAOYSA-N iron(III) oxide Inorganic materials O=[Fe]O[Fe]=O JEIPFZHSYJVQDO-UHFFFAOYSA-N 0.000 description 2
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- 229920000056 polyoxyethylene ether Polymers 0.000 description 2
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- 238000012545 processing Methods 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 239000002562 thickening agent Substances 0.000 description 2
- 239000008096 xylene Substances 0.000 description 2
- 239000005995 Aluminium silicate Substances 0.000 description 1
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- 206010059866 Drug resistance Diseases 0.000 description 1
- 102000015782 Electron Transport Complex III Human genes 0.000 description 1
- 108010024882 Electron Transport Complex III Proteins 0.000 description 1
- 235000007688 Lycopersicon esculentum Nutrition 0.000 description 1
- 239000006002 Pepper Substances 0.000 description 1
- 241001223281 Peronospora Species 0.000 description 1
- 241000233614 Phytophthora Species 0.000 description 1
- 235000016761 Piper aduncum Nutrition 0.000 description 1
- 235000017804 Piper guineense Nutrition 0.000 description 1
- 244000203593 Piper nigrum Species 0.000 description 1
- 235000008184 Piper nigrum Nutrition 0.000 description 1
- 239000005926 Pyridalyl Substances 0.000 description 1
- 241000221662 Sclerotinia Species 0.000 description 1
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 1
- 240000003768 Solanum lycopersicum Species 0.000 description 1
- 235000009754 Vitis X bourquina Nutrition 0.000 description 1
- 235000012333 Vitis X labruscana Nutrition 0.000 description 1
- 240000006365 Vitis vinifera Species 0.000 description 1
- 235000014787 Vitis vinifera Nutrition 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- 235000012211 aluminium silicate Nutrition 0.000 description 1
- BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 description 1
- 229910052921 ammonium sulfate Inorganic materials 0.000 description 1
- 235000011130 ammonium sulphate Nutrition 0.000 description 1
- 230000003042 antagnostic effect Effects 0.000 description 1
- 230000002528 anti-freeze Effects 0.000 description 1
- 229910000019 calcium carbonate Inorganic materials 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000009833 condensation Methods 0.000 description 1
- 230000005494 condensation Effects 0.000 description 1
- 238000012258 culturing Methods 0.000 description 1
- 239000013530 defoamer Substances 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000008686 ergosterol biosynthesis Effects 0.000 description 1
- 150000002191 fatty alcohols Chemical class 0.000 description 1
- 239000000417 fungicide Substances 0.000 description 1
- 238000009775 high-speed stirring Methods 0.000 description 1
- 238000005286 illumination Methods 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 230000002262 irrigation Effects 0.000 description 1
- 238000003973 irrigation Methods 0.000 description 1
- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 239000002609 medium Substances 0.000 description 1
- 230000002438 mitochondrial effect Effects 0.000 description 1
- URXNVXOMQQCBHS-UHFFFAOYSA-N naphthalene;sodium Chemical compound [Na].C1=CC=CC2=CC=CC=C21 URXNVXOMQQCBHS-UHFFFAOYSA-N 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 238000003672 processing method Methods 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- MVILWLLYYQVYNH-UHFFFAOYSA-N pyridine-2-carboxamide Chemical compound NC(=O)C1=CC=CC=N1.NC(=O)C1=CC=CC=N1 MVILWLLYYQVYNH-UHFFFAOYSA-N 0.000 description 1
- 230000000241 respiratory effect Effects 0.000 description 1
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- 230000001225 therapeutic effect Effects 0.000 description 1
- 150000003852 triazoles Chemical group 0.000 description 1
- 239000000230 xanthan gum Substances 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
- 229940082509 xanthan gum Drugs 0.000 description 1
- 235000010493 xanthan gum Nutrition 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/64—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with three nitrogen atoms as the only ring hetero atoms
- A01N43/647—Triazoles; Hydrogenated triazoles
- A01N43/653—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/34—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom
- A01N43/40—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom six-membered rings
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Agronomy & Crop Science (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention discloses a bactericidal composition containing picolinamide and tebuconazole and application thereof, and belongs to the technical field of pesticide compounding. The weight ratio of the picolinamide to the tebuconazole in the bactericidal composition containing the picolinamide to the tebuconazole is 20:1-1:30; preferably, the weight ratio of the picolinamide to the tebuconazole is 2:1-1:5; more preferably, the weight ratio of the picolinamide to the tebuconazole is 1:1-1:2. The effective active components of the bactericidal composition disclosed by the invention, namely the picolinamide and the tebuconazole, have obvious synergistic effect, and the synergistic effect is expressed by reduced application amount, wider disease control spectrum and quicker and more durable bactericidal effect. The pesticide preparation prepared from the plant extract can be used for preventing and treating diseases of vegetables, fruit trees, corns, peanuts and wheat caused by pathogenic bacteria.
Description
Technical Field
The invention belongs to the technical field of pesticide compounding, and particularly relates to a bactericidal composition containing picolinamide and tebuconazole and application thereof.
Background
In recent years, with the change of cultivation and cultivation system, the occurrence degree of crop diseases is increased year by year, and the crop yield and quality are seriously affected. The disease has stronger concealment at the initial stage of occurrence, has smaller influence on the crop yield, is not easy to find, but has stronger infectivity and outbreak, and can be rapidly spread and spread in a short period once the temperature and humidity are proper, so that the crop yield loss caused by the disease is very serious. Chemical sterilization is the most economical and effective means in disease control, and the application of bactericides for disease control has extremely important significance in recovering crop yield loss and improving commodity and quality of agricultural products.
In the process of applying bactericides to control crop diseases, the chemical bactericides with single variety or single action mode are continuously used for a long time in high dosage, so that the problems of crop disease resistance, resistance evolution and the like are easily caused. The reasonable compounding or blending of the bactericide compound has the advantages of expanding disease control spectrum, improving control effect, delaying occurrence and development of disease resistance and drug resistance and the like, and is one of the most effective methods for solving the problems.
Disclosure of Invention
The invention aims to provide a bactericidal composition containing picolinamide and tebuconazole and application thereof in preparation of bactericidal pesticides.
In order to achieve the above purpose, the invention adopts the following technical scheme:
the bactericidal composition containing the picolinamide and the tebuconazole comprises the picolinamide and the tebuconazole, wherein the weight ratio of the picolinamide to the tebuconazole is 20:1-1:30; preferably, the weight ratio of the picolinamide to the tebuconazole is 2:1-1:5; more preferably, the weight ratio of the picolinamide to the tebuconazole is 1:1-1:2.
The application of the bactericidal composition containing the picolinamide and the tebuconazole in preparing bactericidal pesticides.
A bactericidal pesticide, comprising picolinamide and tebuconazole, wherein the weight ratio of picolinamide to tebuconazole is 20:1-1:30; preferably, the weight ratio of the picolinamide to the tebuconazole is 2:1-1:5; more preferably, the weight ratio of the picolinamide to the tebuconazole is 1:1-1:2.
The mass percentage of the picolinamide and the tebuconazole in the bactericidal pesticide accounts for 1-95 percent of the total pesticide, and is preferably 10-80 percent; besides the active ingredients, the bactericidal pesticide also comprises conventional auxiliary agents of the pesticide, wherein the conventional auxiliary agents comprise carriers, dispersing agents, wetting agents, fillers, emulsifying agents, thickening agents, antifreeze agents, solvents and the like which are prepared into different formulations.
The specific formulation of the bactericidal pesticide is one of emulsifiable concentrate, suspending agent, microemulsion, suspending agent, aqueous emulsion, dispersible oil suspending agent, wettable powder, water dispersible granule and suspension seed coating.
The bactericidal composition can be diluted by a user before use or used directly. The preparation can be prepared by common processing method, namely, mixing the active substance with liquid solvent or solid carrier, and adding one or more surfactants such as dispersing agent, stabilizer, wetting agent, adhesive, defoamer, etc.
The bactericidal pesticide is applied to prevention and treatment of diseases of vegetables, fruit trees, corn, peanuts and wheat caused by pathogenic bacteria; wherein the vegetable diseases are tomato anthracnose, gray mold, cucumber powdery mildew, downy mildew, pepper anthracnose and phytophthora root rot; the corn diseases are head smut, rust disease, curvularia leaf spot, large spot disease and small spot disease; the wheat disease is powdery mildew; the peanut disease is leaf spot; the fruit tree diseases are apple alternaria leaf spot, pear scab and grape gray mold.
The bactericidal composition can be applied to leaves, rhizomes and seed parts of plants to be treated, especially to the parts which are harmful to the growth of crops and are affected by bacteria or are easy to be affected by the bacteria by spraying, root irrigation, seed coating and seed dressing. The experimental study shows that the effective active components of the bactericidal composition disclosed by the invention, namely the picolinamide and the tebuconazole, have obvious synergistic effect. The synergistic effect is represented by reduced application amount, wider disease control spectrum, faster and longer sterilization effect.
The technical scheme of the invention has the advantages that:
picolinamide (floryl picoxamid) is a second generation new Picolinamide (Picolinamide) fungicide developed by codihua, under the trade name Adavelt, which acts on the Qi site of the pathogenic mitochondrial respiratory cytochrome bc1 complex, the Qi inhibitor (QiIs). The picolinamide has a wider control spectrum, can be used for controlling powdery mildew, anthracnose, scab and other diseases caused by pathogenic bacteria such as Septoria (Septoria spp.), botrytis (Botrytis spp.), alternaria (Alternaria spp.), and sclerotinia spp, and has a wide application prospect.
Tebuconazole is triazole bactericide with systemic, protective, therapeutic and eradicating activities developed by Bayer company, and the action mechanism of the bactericide is to inhibit ergosterol biosynthesis, can be quickly absorbed by a plant growth-promoting part and mainly transferred to the top, has bactericidal activity, and can promote crop growth, so that the root system of the crop is developed, the leaf color is dark green, the plant is strong, and the effective tillering is increased, thereby improving the yield. The tebuconazole can be used for preventing and treating powdery mildew, rust disease, head smut, alternaria leaf spot and other diseases of cereal, corn, peanut, fruit tree, vegetable and other crops.
(1) The bactericidal composition is an environment-friendly bactericide, is easy to degrade in the environment, and is safe for both the stubble crops and the succeeding crop.
(2) The bactericidal composition has the characteristics of low cost, convenient use and easy popularization, and has great economic and social benefits.
(3) Compared with the prior art, the bactericidal composition can prevent and remove vegetable and grain crop diseases such as cucumber downy mildew, powdery mildew, corn curvularia leaf spot, wheat powdery mildew and the like, and fruit tree diseases such as apple alternaria leaf spot, pear scab and the like.
Detailed Description
The terms used in the present invention generally have meanings commonly understood by those of ordinary skill in the art unless otherwise indicated.
The invention will be described in further detail below in connection with specific embodiments and with reference to the data. The following examples are intended to illustrate the invention and are not intended to limit the scope of the invention in any way.
Example 1
The bactericidal composition containing the picolinamide and the tebuconazole, wherein the weight ratio of the picolinamide to the tebuconazole is 1:30.
Example 2
The bactericidal composition containing the picolinamide and the tebuconazole, wherein the weight ratio of the picolinamide to the tebuconazole is 1:20.
Example 3
The bactericidal composition containing the picolinamide and the tebuconazole, wherein the weight ratio of the picolinamide to the tebuconazole is 1:10.
Example 4
The bactericidal composition containing the picolinamide and the tebuconazole, wherein the weight ratio of the picolinamide to the tebuconazole is 1:5.
Example 5
The bactericidal composition containing the picolinamide and the tebuconazole, wherein the weight ratio of the picolinamide to the tebuconazole is 1:2.
Example 6
The bactericidal composition containing the picolinamide and the tebuconazole, wherein the weight ratio of the picolinamide to the tebuconazole is 1:1.
Example 7
The bactericidal composition containing the picolinamide and the tebuconazole, wherein the weight ratio of the picolinamide to the tebuconazole is 2:1.
Example 8
The bactericidal composition containing the picolinamide and the tebuconazole, wherein the weight ratio of the picolinamide to the tebuconazole is 5:1.
Example 9
The bactericidal composition containing the picolinamide and the tebuconazole, wherein the weight ratio of the picolinamide to the tebuconazole is 10:1.
Example 10
The bactericidal composition containing the picolinamide and the tebuconazole, wherein the weight ratio of the picolinamide to the tebuconazole is 20:1.
Researches on prevention and treatment effect of picolinamide and tebuconazole on cucumber downy mildew (indoor toxicity measurement)
Taking cucumber downy mildew (Pseudoperonospora cubensis) as an example, the virulence of picolinamide, tebuconazole and mixed formulations thereof is determined by adopting a (FAO) leaf disc floating method, and the specific method is as follows:
test agent-pyridine bacteria amide original drug and tebuconazole original drug. Dissolving picolinamide and tebuconazole in acetone, preparing 10000 μg/mL mother liquor, adding emulsifier Tween-80 with volume fraction of 0.2%, and storing in refrigerator at 4deg.C.
Single dose toxicity determination method:
the test agents (including pyridine fungus amide and tebuconazole) are prepared into 5-7 concentration gradients, and are respectively poured into culture dishes with the diameter of 9cm, 20mL of each dish is used as a control, and Tween-80 water solution without the agents is used as a control. Fresh cucumber leaves were collected and punched with a punch to form leaf discs 1.5cm in diameter. The back of the leaf disc floats upwards in the culture dishes of the liquid medicines with different concentrations, 5 sheets/dish are repeated for 4 dishes per concentration. 10 mu L of 1X 10 is connected with the center point of each leaf disk 4 ～1×10 5 Individual sporangia/mL suspensions. Then placing the mixture into an illumination incubator with the light-dark ratio of 16:8 at the temperature of 18-20 ℃ for culturing, and investigating the illness state after 7 d. Disease stages are classified according to the percentage of spore-producing area to the whole leaf disc area: grade 0, no disease; 1 grade 1-5%; 3 stages: 6% -10%; 5 stages: 11% -25%; 7 stages: 26% -50%; stage 9: > 50%. The disease index and the prevention and treatment effect are calculated as follows:
determination of combined toxicity of the mixture:
on the basis of single-dose toxicity measurement, picolinamide and tebuconazole are mixed into 10 proportions according to the weight ratio of 1:30, 1:20, 1:10, 1:5, 1:2, 1:1, 2:1, 5:1, 10:1 and 20:1 respectively; tests are carried out according to the liquid medicine diluted into 5-7 series concentrations according to different proportions, the control effect of the mixed medicine on the cucumber downy mildew (Pseudoperonospora cubensis) is determined, and each treatment is repeated for 4 times. The concentration EC in the effective inhibition of the mixed medicament on the pathogenic bacteria is obtained by linear regression analysis between the control effect rate value of the pathogenic bacteria and the medicament concentration logarithmic value 50 Values and CTC values.
Number of testsThe EC of each agent was calculated by statistical analysis from Microsoft Excel 2003, DPS17.10 data processing platforms 50 Value, 95% confidence limit. And calculating the co-toxicity coefficient of the mixed agent by using a grand cloud Peel method (1960), and evaluating the synergistic effect of the mixed agent according to the co-toxicity coefficient.
The inhibition of each agent was calculated according to the following formula:
toxicity index ti= (standard agent EC 50 Test agent EC 50 )×100
Actual toxicity index ati= (standard agent EC 50/formulation EC 50 )×100
Theoretical toxicity index of the mixture tti=ti×pa of the single agent a+ti×pb of the single agent B (PA and PB are the percentage of active ingredients in the mixture, respectively)
Co-toxicity coefficient CTC = actual toxicity index of the compound ATI/theoretical toxicity index of the compound TTI x 100
Judging the synergy: CTC is more than or equal to 120, and has synergistic effect; CTC is 80 < 120, which is additive; CTC is less than or equal to 80, and is antagonistic.
The results are shown in tables 1 and 2.
Results of toxicity measurement of the 12 Agents against Peronospora Cucumidis
TABLE 2 determination of virulence of Pyridinecarboxamide and tebuconazole in different ratios for cucumber downy mildew
As can be seen from tables 1 and 2, the picolinamide, the tebuconazole and the mixed preparation thereof have good control effect on cucumber downy mildew, wherein when the ratio of the picolinamide to the tebuconazole is between 1:1 and 1:5, the co-toxicity coefficient of the picolinamide to the pathogenic bacteria to be tested is more than 120, which shows that the two bactericides have good synergistic effect under the ratio, and especially the synergistic effect is more remarkable when the ratio is between 1:1 and 1:2.
Researches on prevention and treatment effect of pyridine fungus amide and tebuconazole on corn curvularia leaf spot disease (indoor toxicity measurement)
Taking Curvularia lunata (Curvularia lunata) as an example, the virulence of pyridine fungus amide, tebuconazole and mixed preparations thereof is measured by a hypha growth rate method, and the specific method is as follows:
test agent-pyridine bacteria amide original drug and tebuconazole original drug. Dissolving picolinamide and tebuconazole in acetone, preparing 10000 μg/mL mother liquor, adding emulsifier Tween-80 with volume fraction of 0.2%, and storing in refrigerator at 4deg.C.
Single dose toxicity determination method:
the pathogenic bacteria are pre-cultured on PDA culture medium at 26 deg.C for 5d, bacterial cake is taken by a puncher with diameter of 5mm on the same circumference near the edge of the bacterial colony, inoculated on culture medium plates containing different medicament (including pyridine bacteria amide and tebuconazole) concentrations, one for each dish is cultured in a constant temperature cabinet at 26 deg.C for 6d, the growth diameter of each treated bacterial colony is measured by a crisscross method, and the treatment is repeated for 4 times with clear water as a control. The radial linear growth of the colony is measured, and the inhibition rate of the medicament to the colony growth is determined. By linear regression analysis between the hypha growth inhibition value and the agent concentration log value, the effective inhibitory intermediate concentration (EC) of each agent on the strain was found 50 Values).
Determination of combined toxicity of the mixture:
on the basis of single-dose toxicity measurement, picolinamide and tebuconazole are mixed into 10 proportions according to the weight ratio of 1:30, 1:20, 1:10, 1:5, 1:2, 1:1, 2:1, 5:1, 10:1 and 20:1 respectively; preparing 5-7 series concentration PDA culture media containing medicine according to different ratios, and determining the inhibition rate of the medicine to colony growth. Each treatment was repeated 4 times. Obtaining the mixed medicament by linear regression analysis between the hypha growth inhibition value and the medicament concentration logarithmic valueEffective inhibition of strains at moderate concentrations of EC 50 Values and CTC values, PDA medium without agent was used as control.
The test data are statistically analyzed by Microsoft Excel 2003 and DPS17.10 data processing working platform to calculate EC of each medicament 50 Value, 95% confidence limit. And calculating the co-toxicity coefficient of the mixed agent by using a grand cloud Peel method (1960), and evaluating the synergistic effect of the mixed agent according to the co-toxicity coefficient.
The results are shown in tables 3 and 4.
Table 3 2 results of toxicity measurement of the agents against Curvularia lunata
TABLE 4 toxicity determination results of Pyridinium amide and Tebuconazole in different ratios for Curvularia lunata
As can be seen from tables 3 and 4, the picolinamide, the tebuconazole and the mixed preparation thereof can effectively inhibit the hypha growth of the corn curvularia leaf spot, wherein when the ratio of the picolinamide to the tebuconazole is between 1:5 and 2:1, the co-toxicity coefficients of the picolinamide to the pathogenic bacteria to be tested are above 120, which indicates that the two bactericides have good synergistic effect under the ratio, and especially the synergistic effect is more remarkable when the ratio is between 1:1 and 1:2.
Example 11
24% pyridine fungus amide tebuconazole wettable powder comprises the following components in percentage by weight:
12% of picolinide, 12% of tebuconazole, 2% of sodium alkyl naphthalene sulfonate formaldehyde condensate (dispersing agent), 3% of sodium lignin sulfonate (dispersing agent), 3% of sodium dodecyl sulfate (wetting agent), 20% of white carbon black (filler) and 100% of kaolin (filler).
The preparation method comprises the following steps: the active ingredients, various auxiliary agents and fillers are fully and uniformly mixed according to a proportion, and the mixture is crushed by a superfine crusher to prepare 24% pyridine fungus amide tebuconazole wettable powder.
The embodiment is applied to preventing and controlling cucumber downy mildew and corn curvularia leaf spot, enters the initial stage of disease, is sprayed with water at different concentrations, and is continuously applied for 2 times every 7 days. The control effect is shown in the following table 5.
Table 5 field effects of different formulations of picolinamide and tebuconazole for controlling cucumber downy mildew and corn curvularia leaf spot
As can be seen from Table 5, the synergistic effect of the picolinamide and the tebuconazole is obvious after the picolinamide and the tebuconazole are mixed, the control effect on two diseases is obviously better than that of a single agent, and the dosage of the effective components is obviously reduced.
Example 12
24% of picolinamide tebuconazole suspending agent comprises the following components in percentage by weight:
8% of picolinide, 16% of tebuconazole, 5% of alkyl naphthalene sodium sulfonate formaldehyde condensate (dispersing agent), 3% of castor oil polyoxyethylene ether (emulsifying agent), 5% of fatty alcohol polyoxyethylene ether (emulsifying agent), 3% of methylene dinaphthyl sodium sulfonate (wetting agent), 2% of xanthan gum (thickening agent), 4% of glycerol (antifreeze agent) and the balance of water to 100%.
The preparation method comprises the following steps: the active ingredients, various auxiliary agents and water are fully and uniformly mixed according to a proportion, and are put into a sand mill to be ground to the particle size of 5 mu m, thus obtaining the 24% pyridine fungus amide tebuconazole suspending agent.
The embodiment is applied to preventing and controlling cucumber downy mildew and corn curvularia leaf spot, enters the initial stage of disease, is sprayed with water at different concentrations, and is continuously applied for 2 times every 7 days. The control effect is shown in Table 6 below.
Surface 6 field effect of Pyridinamide and Tebuconazole different preparations for preventing and treating cucumber downy mildew and corn curvularia leaf spot
As can be seen from Table 6, the synergistic effect of the picolinamide and the tebuconazole is obvious after the picolinamide and the tebuconazole are mixed, the control effect on two diseases is obviously better than that of a single agent, and the dosage of the effective components is obviously reduced.
Example 13
24% pyridalyl tebuconazole emulsifiable concentrate comprises the following components in percentage by weight:
8% of picolinamide, 16% of tebuconazole, 25% of cyclohexane (solvent), 3% of pesticide emulsion No. 600 (commercial emulsifier), 5% of castor oil polyethylene glycol condensation (emulsifier), 4% of glycerol (antifreeze) and the balance of xylene to 100%.
The preparation method comprises the following steps: and (3) fully mixing the active ingredients, various auxiliary agents and xylene according to a proportion, adding the mixture into a mixing kettle, and uniformly stirring to obtain 24% pyridalyl-tebuconazole missible oil.
The embodiment is applied to preventing and controlling cucumber downy mildew and corn curvularia leaf spot, enters the initial stage of disease, is sprayed with water at different concentrations, and is continuously applied for 2 times every 7 days. The control effect is shown in Table 7 below.
Table 7 field effects of different formulations of picolinamide and tebuconazole for controlling cucumber downy mildew and corn curvularia leaf spot
As can be seen from Table 7, the synergistic effect of the picolinamide and the tebuconazole is obvious after the picolinamide and the tebuconazole are mixed, the control effect on two diseases is obviously better than that of a single agent, and the dosage of the effective components is obviously reduced.
Example 14
24% pyridine fungus amide tebuconazole aqueous emulsion comprises the following components in percentage by weight:
8% of picolinamide, 16% of tebuconazole, 20% of cyclohexane (solvent), 3% of pesticide emulsion No. 600 (emulsifier), 5% of castor oil polyethylene glycol condensate (emulsifier), 5% of sodium alkyl naphthalene sulfonate formaldehyde condensate (dispersing agent) and the balance of water to 100%.
The preparation method comprises the following steps: the active ingredients and the auxiliary agents are fully mixed according to a certain proportion, so that the active ingredients and the auxiliary agents are dissolved into a uniform oil phase, and the oil phase and the water phase are mixed under high-speed stirring to obtain 24% pyridine fungus amide tebuconazole aqueous emulsion.
The embodiment is applied to preventing and controlling cucumber downy mildew and corn curvularia leaf spot, enters the initial stage of disease, is sprayed with water at different concentrations, and is continuously applied for 2 times every 7 days. The control effect is shown in the following table 8.
Surface 8 field effect of different preparations of picolinamide and tebuconazole for preventing and treating cucumber downy mildew and corn curvularia leaf spot
As can be seen from Table 8, the synergistic effect of the picolinamide and the tebuconazole is obvious after the picolinamide and the tebuconazole are mixed, the control effect on two diseases is obviously better than that of a single agent, and the dosage of the effective components is obviously reduced.
Example 15
24% pyridalyl-tebuconazole water dispersible granule comprises the following components in percentage by weight:
12% of picolinide, 12% of tebuconazole, 5% of alkyl naphthalene sulfonate formaldehyde condensate (dispersing agent), 5% of sodium lignin sulfonate (dispersing agent), 2% of methylene dinaphthyl sulfonate sodium (wetting agent), 3% of ammonium sulfate (disintegrating agent), 30% of white carbon black (filler) and 100% of calcium carbonate (filler).
The preparation method comprises the following steps: the active ingredients, sodium alkyl naphthalene sulfonate formaldehyde condensate, wetting agent, disintegrating agent and filler are fully mixed according to a proportion, crushed to a particle size of 5 mu m by a jet mill to obtain mother powder, and the mother powder and sodium lignin sulfonate are fully mixed, granulated, dried and sieved to obtain 24% pyridine fungus amide tebuconazole water dispersible granules.
The embodiment is applied to preventing and controlling cucumber downy mildew and corn curvularia leaf spot, enters the initial stage of disease, is sprayed with water at different concentrations, and is continuously applied for 2 times every 7 days. The control effect is shown in Table 9 below.
Surface 9 field effect of Pyridinamide and Tebuconazole different preparations for preventing and treating cucumber downy mildew and corn curvularia leaf spot
As can be seen from Table 9, the synergistic effect of the picolinamide and the tebuconazole is obvious after the picolinamide and the tebuconazole are mixed, the control effect on two diseases is obviously better than that of a single agent, and the dosage of the effective components is obviously reduced.
The above description is only a preferred embodiment of the present invention, and is not intended to limit the invention in any way, and any person skilled in the art may make modifications or alterations to the disclosed technical content to the equivalent embodiments. However, any simple modification, equivalent variation and variation of the above embodiments according to the technical substance of the present invention still fall within the protection scope of the technical solution of the present invention.
Claims (7)
1. The bactericidal composition containing the picolinamide and the tebuconazole is characterized by comprising the picolinamide and the tebuconazole, wherein the weight ratio of the picolinamide to the tebuconazole is 1:1-1:2.
2. The use of the fungicidal composition containing picolinamide and tebuconazole according to claim 1 in the preparation of fungicidal pesticides.
3. The bactericidal pesticide is characterized by comprising picolinamide and tebuconazole, wherein the weight ratio of picolinamide to tebuconazole is 1:1-1:2.
4. A bactericidal pesticide according to claim 3, wherein the mass percentage of picolinamide and tebuconazole in the bactericidal pesticide is 1-95% of the total pesticide.
5. The sterilization pesticide according to claim 4, wherein the mass percentage of the picolinamide and the tebuconazole in the sterilization pesticide accounts for 10-80% of the total pesticide.
6. The sterilization pesticide according to claim 5, wherein the sterilization pesticide is one of emulsifiable concentrate, suspending agent, microemulsion, suspoemulsion, aqueous emulsion, dispersible oil suspending agent, wettable powder, water dispersible granule and suspension seed coating.
7. The use of the bactericidal pesticide of claim 6 for preventing and controlling cucumber downy mildew and corn curvularia leaf spot.
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| CN112584704A (en) * | 2018-08-08 | 2021-03-30 | 巴斯夫欧洲公司 | Use of derivatives of fungicidally active compound I and mixtures thereof in methods of seed application and treatment |
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| CN113163762A (en) * | 2018-09-27 | 2021-07-23 | 0903608Bc有限公司 | Synergistic pesticidal compositions for delivery of pesticidal active ingredients and methods thereof |
| JP2019048845A (en) * | 2018-11-07 | 2019-03-28 | 住友化学株式会社 | Composition containing heterocyclic compound |
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