CN114502723A - 一种经修饰的免疫细胞及其用途 - Google Patents
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Abstract
提供了一种经修饰的免疫细胞，其包含嵌合抗原受体和/或其编码元件，或者包含T细胞受体和/或其编码元件，且该免疫细胞还包含：瘦素和/或其功能性片段；和/或，瘦素受体和/或其功能性片段，且与未经相应经修饰的免疫细胞相比，该免疫细胞中的瘦素受体和/或其功能性片段的表达量增加。此外，还提供一种经修饰的免疫细胞，其包含瘦素和/或其功能性片段，和/或，瘦素受体和/或其功能性片段，以及低密度脂蛋白受体相关蛋白或其片段。
Description
PCT国内申请，说明书已公开。
Claims (126)
- PCT国内申请，权利要求书已公开。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910917070 | 2019-09-26 | ||
| CN2019109170706 | 2019-09-26 | ||
| PCT/CN2020/117936 WO2021057932A1 (zh) | 2019-09-26 | 2020-09-25 | 一种经修饰的免疫细胞及其用途 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN114502723A true CN114502723A (zh) | 2022-05-13 |
| CN114502723B CN114502723B (zh) | 2024-09-13 |
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| CN202080067420.5A Active CN114502723B (zh) | 2019-09-26 | 2020-09-25 | 一种经修饰的免疫细胞及其用途 |
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| US (1) | US20220389076A1 (zh) |
| EP (1) | EP4036222A4 (zh) |
| JP (1) | JP2022549468A (zh) |
| CN (1) | CN114502723B (zh) |
| WO (1) | WO2021057932A1 (zh) |
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| JP2024517719A (ja) | 2021-04-27 | 2024-04-23 | オリセル セラピューティクス カンパニー リミテッド | Ｂｃｍａを標的としたキメラ型抗原受容体及びその応用 |
| CN115477704B (zh) * | 2021-06-16 | 2024-02-23 | 四川大学华西医院 | 一种基于lox1构建的嵌合抗原受体免疫细胞制备及其应用 |
Citations (5)
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| US20070172844A1 (en) * | 2005-09-28 | 2007-07-26 | University Of South Florida | Individualized cancer treatments |
| CN101627121A (zh) * | 2006-12-08 | 2010-01-13 | 奥斯瑞根公司 | 作为治疗干预的靶标的miRNA调控基因和路径 |
| US20100323383A1 (en) * | 2008-04-15 | 2010-12-23 | Nicolas Manel | Methods for in vitro differentiation of Th-17+cells |
| CN105683379A (zh) * | 2013-06-17 | 2016-06-15 | 布罗德研究所有限公司 | 用于对有丝分裂后细胞的疾病和障碍进行靶向和建模的系统、方法和组合物的递送、工程化和优化 |
| WO2017075537A1 (en) * | 2015-10-30 | 2017-05-04 | Aleta Biotherapeutics Inc. | Compositions and methods for treatment of cancer |
-
2020
- 2020-09-25 CN CN202080067420.5A patent/CN114502723B/zh active Active
- 2020-09-25 JP JP2022518931A patent/JP2022549468A/ja active Pending
- 2020-09-25 WO PCT/CN2020/117936 patent/WO2021057932A1/zh unknown
- 2020-09-25 US US17/764,128 patent/US20220389076A1/en active Pending
- 2020-09-25 EP EP20867583.5A patent/EP4036222A4/en active Pending
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| US20070172844A1 (en) * | 2005-09-28 | 2007-07-26 | University Of South Florida | Individualized cancer treatments |
| CN101627121A (zh) * | 2006-12-08 | 2010-01-13 | 奥斯瑞根公司 | 作为治疗干预的靶标的miRNA调控基因和路径 |
| US20100323383A1 (en) * | 2008-04-15 | 2010-12-23 | Nicolas Manel | Methods for in vitro differentiation of Th-17+cells |
| CN105683379A (zh) * | 2013-06-17 | 2016-06-15 | 布罗德研究所有限公司 | 用于对有丝分裂后细胞的疾病和障碍进行靶向和建模的系统、方法和组合物的递送、工程化和优化 |
| WO2017075537A1 (en) * | 2015-10-30 | 2017-05-04 | Aleta Biotherapeutics Inc. | Compositions and methods for treatment of cancer |
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Also Published As
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| JP2022549468A (ja) | 2022-11-25 |
| EP4036222A1 (en) | 2022-08-03 |
| CN114502723B (zh) | 2024-09-13 |
| WO2021057932A1 (zh) | 2021-04-01 |
| US20220389076A1 (en) | 2022-12-08 |
| EP4036222A4 (en) | 2023-10-25 |
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