CN114452026B - An enamel caries detection system based on terahertz spectroscopy imaging - Google Patents
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Abstract
Description
技术领域Technical field
本发明涉及太赫兹谱学成像技术,尤其涉及一种基于太赫兹谱学成像技术的釉质龋检测系统。The present invention relates to terahertz spectroscopy imaging technology, and in particular to an enamel caries detection system based on terahertz spectroscopy imaging technology.
背景技术Background technique
根据2017年发布的《第四次全国口腔疾病流行病学调查报告》的调查结果,近年来我国自儿童至老年人,恒牙患龋率呈快速上升态势。龋病(dental caries)是指在细菌等多种因素作用下,导致牙体硬组织无机物脱矿、有机物分解,进而形成慢性进行性破坏为主要改变的慢性感染性疾病。According to the findings of the "Fourth National Oral Disease Epidemiological Survey Report" released in 2017, the caries rate in permanent teeth has been rising rapidly in my country from children to the elderly in recent years. Dental caries refers to a chronic infectious disease in which the inorganic matter of the dental hard tissue is demineralized and the organic matter is decomposed under the action of bacteria and other factors, resulting in chronic progressive destruction as the main change.
目前,临床对于龋齿的检测方法主要采用视诊、X射线诊断、CT、激光荧光诊断等。其中,视诊通过肉眼直接观察牙齿有无破损、颜色改变等情况,但常在出现龋洞后才能得出诊断。X射线诊断使用X射线照射牙齿进行二维透射成像,可诊断不易发现的隐匿性龋、邻面龋等,但X射线穿过人体时会产生一定的生物学效应,尽管口腔X射线检测的放射剂量很低,孕妇和儿童仍应尽量避免接触。口腔CT可重建牙齿的三维形貌,与X光牙片相比可更加详细的诊断,但仅适用于较大的或已形成龋病的检测,难以对早期龋齿进行检测,且同样存在电离辐射的放射性危害问题。激光荧光检测侧重于定性分析,检测时受牙齿表面分布均匀性变化影响大,且不能对邻面龋进行检测。At present, the clinical detection methods for dental caries mainly use visual inspection, X-ray diagnosis, CT, laser fluorescence diagnosis, etc. Among them, visual inspection directly observes whether the teeth are damaged or changed color with the naked eye, but the diagnosis can only be made after cavities appear. X-ray diagnosis uses X-rays to irradiate teeth for two-dimensional transmission imaging, which can diagnose occult caries, proximal caries, etc. that are difficult to find. However, X-rays will produce certain biological effects when they pass through the human body. Although the radiation of oral X-ray detection The dose is very low, and pregnant women and children should still try to avoid exposure. Oral CT can reconstruct the three-dimensional morphology of teeth and can provide a more detailed diagnosis compared with dental X-rays. However, it is only suitable for the detection of larger or already formed caries. It is difficult to detect early caries and also contains ionizing radiation. of radioactive hazards. Laser fluorescence detection focuses on qualitative analysis, which is greatly affected by changes in the distribution uniformity of the tooth surface, and cannot detect proximal caries.
由上可知,现有的检测方法难以对早期龋、隐蔽龋进行安全、准确、精准地检测识别。It can be seen from the above that existing detection methods are difficult to detect and identify early caries and hidden caries safely, accurately and accurately.
发明内容Contents of the invention
针对现有技术中的缺陷,本发明提出了一种基于太赫兹谱学成像的釉质龋检测系统,该检测系统利用龋病组织和健康组织对于太赫兹时域透射和反射信号的响应差异,在成像中形成对比度,进而实现釉质龋的早期筛查。In view of the deficiencies in the prior art, the present invention proposes an enamel caries detection system based on terahertz spectroscopy imaging. The detection system utilizes the difference in response of caries tissue and healthy tissue to terahertz time domain transmission and reflection signals. Contrast is created in imaging, enabling early screening of enamel caries.
本发明的具体技术方案如下:The specific technical solutions of the present invention are as follows:
一种基于太赫兹谱学成像的釉质龋检测系统,包括:飞秒激光产生及传导单元、太赫兹发射天线、第一偏振太赫兹探测天线、第二偏振太赫兹探测天线、天线控制单元、同步单元、距离探测与控制单元、光谱信号处理单元、成像重构单元和显示单元;其中,An enamel caries detection system based on terahertz spectroscopy imaging, including: femtosecond laser generation and conduction unit, terahertz transmitting antenna, first polarized terahertz detection antenna, second polarized terahertz detection antenna, antenna control unit, synchronization unit, distance detection and control unit, spectral signal processing unit, imaging reconstruction unit and display unit; among which,
飞秒激光产生及传导单元:用于产生线偏振太赫兹脉冲光;Femtosecond laser generation and transmission unit: used to generate linearly polarized terahertz pulse light;
太赫兹发射天线:用于对被检测牙齿发射线偏振太赫兹脉冲光;Terahertz transmitting antenna: used to emit linearly polarized terahertz pulse light to the tooth being detected;
第一偏振太赫兹探测天线:用于探测透过被检测牙齿的太赫兹脉冲光;First polarized terahertz detection antenna: used to detect terahertz pulse light that passes through the tooth being detected;
第二偏振太赫兹探测天线:用于探测自被检测牙齿反射的太赫兹脉冲光;Second polarization terahertz detection antenna: used to detect terahertz pulse light reflected from the tooth being detected;
天线控制单元:用于旋转控制太赫兹发射天线、第一偏振太赫兹探测天线和第二偏振太赫兹探测天线的方位角,以发射和探测不同线偏振方向的太赫兹脉冲光;Antenna control unit: used to rotate and control the azimuth angles of the terahertz transmitting antenna, the first polarized terahertz detection antenna and the second polarized terahertz detection antenna to emit and detect terahertz pulse light in different linear polarization directions;
同步单元:用于在旋转时保持太赫兹发射天线、第一偏振太赫兹探测天线和第二偏振太赫兹探测天线的旋转方位角相同;Synchronization unit: used to maintain the same rotation azimuth angle of the terahertz transmitting antenna, the first polarized terahertz detection antenna and the second polarized terahertz detection antenna during rotation;
距离探测与控制单元:用于获取太赫兹发射天线、第一偏振太赫兹探测天线和第二偏振太赫兹探测天线至被检测牙齿表面的距离,防止发生碰撞,并计算被检测牙齿的厚度;Distance detection and control unit: used to obtain the distance from the terahertz transmitting antenna, the first polarized terahertz detection antenna and the second polarized terahertz detection antenna to the surface of the detected tooth, prevent collision, and calculate the thickness of the detected tooth;
光谱信号处理单元:用于处理第一偏振太赫兹探测天线和第二偏振太赫兹探测天线探测所得的太赫兹时域光谱信号;Spectral signal processing unit: used to process the terahertz time domain spectrum signals detected by the first polarized terahertz detection antenna and the second polarized terahertz detection antenna;
成像重构单元:依据光谱信号处理单元处理所得的数据,生成被检测牙齿透射和反射的多种成像数据;Imaging reconstruction unit: Based on the data processed by the spectral signal processing unit, it generates a variety of imaging data of transmission and reflection of the detected teeth;
显示单元:用于将成像重构单元重构的成像数据进行外部显示。Display unit: used for external display of the imaging data reconstructed by the imaging reconstruction unit.
优选的,所述光谱信号处理单元处理数据的方法包括:计算峰峰值、快速傅里叶变换、计算飞行时间、计算折射率和方位角各向异性程度分析。Preferably, the method for processing data by the spectral signal processing unit includes: calculating peak-to-peak values, fast Fourier transform, calculating time of flight, calculating refractive index and analyzing the degree of azimuthal anisotropy.
优选的,所述方位角各向异性程度分析为:在同一个检测位置,以一个固定角度进行同步步进旋转太赫兹发射天线、第一偏振太赫兹探测天线和第二偏振太赫兹探测天线的方位角,产生和探测不同方向的线偏振太赫兹脉冲光,记录每个方位角下的时域信号;旋转一周后,统计每个方位角下太赫兹脉冲的峰峰值,计算所有方位角中最大峰峰值和最小峰峰值的比,视为第一各向异性程度,计算所有方位角中最大峰峰值和与最大峰峰值对应方位角相正交角度的峰峰值的比,视为第二各向异性程度,计算每个方位角下最大折射率和最小折射率的比,视为第三各向异性程度。Preferably, the analysis of the degree of azimuth anisotropy is: at the same detection position, the terahertz transmitting antenna, the first polarized terahertz detection antenna and the second polarized terahertz detection antenna are synchronously rotated at a fixed angle. Azimuth angle, generate and detect linearly polarized terahertz pulse light in different directions, record the time domain signal at each azimuth angle; after one rotation, count the peak-to-peak value of the terahertz pulse at each azimuth angle, and calculate the maximum among all azimuth angles The ratio of the peak-to-peak value to the minimum peak-to-peak value is regarded as the first degree of anisotropy. The ratio of the maximum peak-to-peak value in all azimuth angles to the peak-to-peak value at an angle orthogonal to the azimuth angle corresponding to the maximum peak-peak value is calculated and regarded as the second degree of anisotropy. For the degree of anisotropy, calculate the ratio of the maximum refractive index to the minimum refractive index at each azimuth angle, which is regarded as the third degree of anisotropy.
优选的,所述成像重构单元生成成像数据的方法包括:峰峰值成像、飞行时间层析成像、折射率成像、频域幅值成像、频域相位成像和方位角各向异性程度成像。Preferably, the method for generating imaging data by the imaging reconstruction unit includes: peak-to-peak imaging, time-of-flight tomography, refractive index imaging, frequency domain amplitude imaging, frequency domain phase imaging and azimuthal anisotropy degree imaging.
优选的,所述方位角各向异性程度成像为:第一各项异性程度成像将第一各向异性程度作为该位置成像像素的数值大小,第二各项异性程度成像将第二各向异性程度作为该位置成像像素的数值大小,第三各向异性程度成像将第三各向异性程度作为该位置成像像素的数值大小。Preferably, the azimuthal anisotropy degree imaging is as follows: the first anisotropy degree imaging uses the first anisotropy degree as the numerical size of the imaging pixel at the position, and the second anisotropy degree imaging uses the second anisotropy degree The degree is used as the numerical size of the imaging pixel at this position, and the third degree of anisotropy imaging uses the third degree of anisotropy as the numerical size of the imaging pixel at this position.
相比于现有技术,本发明具有以下有益效果:Compared with the prior art, the present invention has the following beneficial effects:
1.本发明的检测系统使用太赫兹波进行检测,太赫兹波相比于会产生电离辐射的X射线,光子能量更低,在1THz时仅约为4.1meV,不会对生物组织产生有害的电离辐射,非常适用于活体生物组织检测。而相比于可见光和红外光,太赫兹波的穿透性更强,适用于牙齿表面以下的龋病表征。1. The detection system of the present invention uses terahertz waves for detection. Compared with X-rays that produce ionizing radiation, terahertz waves have lower photon energy, only about 4.1meV at 1THz, and will not cause harmful effects on biological tissues. Ionizing radiation is very suitable for detection of living biological tissue. Compared with visible light and infrared light, terahertz waves are more penetrating and are suitable for characterization of caries below the tooth surface.
2.本发明的检测系统集成了太赫兹波透射信号和反射信号。龋病位置的透射信号相较于健康位置处具有明显的衰减,且可通过计算折射率来辨别牙釉质和牙本质;反射信号可以利用时间延迟进行飞行时间层析,且可进行傅里叶变换进行频谱成像,实现三维重构。2. The detection system of the present invention integrates terahertz wave transmission signals and reflection signals. The transmission signal at the carious location has a significant attenuation compared to the healthy location, and the refractive index can be calculated to identify enamel and dentin; the reflection signal can be time-delayed for time-of-flight tomography, and Fourier transform can be performed Perform spectrum imaging to achieve three-dimensional reconstruction.
3.本发明的检测系统通过控制单元和同步单元实现发射天线和探测天线的方位角同步旋转,即保持牙齿不动的情况下,调整太赫兹激励源的偏振方向,引入偏振角度依赖测量。健康的牙釉质在受到不同偏振方向的太赫兹波辐射时,会产生明显的角度依赖现象,而对于龋病的牙釉质,这种现象则会明显减弱,利用这一特征参数进行精细化检测,提高了检测效果的准确性。3. The detection system of the present invention realizes synchronous rotation of the azimuth angles of the transmitting antenna and the detection antenna through the control unit and the synchronization unit, that is, while keeping the teeth stationary, the polarization direction of the terahertz excitation source is adjusted and polarization angle-dependent measurement is introduced. When healthy tooth enamel is radiated by terahertz waves with different polarization directions, it will produce an obvious angle-dependent phenomenon. However, for carious tooth enamel, this phenomenon will be significantly weakened. This characteristic parameter can be used for refined detection. Improved the accuracy of detection results.
附图说明Description of the drawings
为了更清楚地说明本发明具体实施方式或现有技术中的技术方案,下面将对具体实施方式或现有技术描述中所需要使用的附图作简单地介绍,显而易见地,下面描述中的附图是本发明的实施过程和细节,对于本领域普通技术人员来讲,在不付出创造性劳动的前提下,还可以根据这些附图获得其他的附图。In order to more clearly explain the specific embodiments of the present invention or the technical solutions in the prior art, the accompanying drawings that need to be used in the description of the specific embodiments or the prior art will be briefly introduced below. Obviously, the drawings in the following description The drawings illustrate the implementation process and details of the present invention. For those of ordinary skill in the art, other drawings can be obtained based on these drawings without exerting creative efforts.
图1是本发明的基于太赫兹谱学成像的釉质龋检测系统的示意图;Figure 1 is a schematic diagram of the enamel caries detection system based on terahertz spectroscopy imaging of the present invention;
图2是应用本发明的检测系统进行龋齿检测的流程图;Figure 2 is a flow chart of applying the detection system of the present invention to detect dental caries;
附图标号说明:Explanation of reference numbers:
1-基于太赫兹谱学成像的釉质龋检测系统,2-太赫兹发射天线,3-第一偏振太赫兹探测天线,4-第二偏振太赫兹探测天线,5-天线控制单元,6-同步单元,7-距离探测与控制单元,8-光谱信号处理单元,9-成像重构单元,10-显示单元,11-飞秒激光产生及传导单元。1-Enamel caries detection system based on terahertz spectroscopy imaging, 2-terahertz transmitting antenna, 3-first polarization terahertz detection antenna, 4-second polarization terahertz detection antenna, 5-antenna control unit, 6-synchronization Unit, 7-distance detection and control unit, 8-spectral signal processing unit, 9-imaging reconstruction unit, 10-display unit, 11-femtosecond laser generation and conduction unit.
具体实施方式Detailed ways
为了能够更清楚地理解本发明的上述目的、特征和优点,下面结合附图和具体实施方式对本发明进行进一步的详细描述。需要说明的是,在不冲突的情况下,本发明的实施例及实施例中的特征可以相互组合。In order to more clearly understand the above objects, features and advantages of the present invention, the present invention will be described in further detail below in conjunction with the accompanying drawings and specific embodiments. It should be noted that, as long as there is no conflict, the embodiments of the present invention and the features in the embodiments can be combined with each other.
在下面的描述中阐述了很多具体细节以便于充分理解本发明,但是,本发明还可以采用其他不同于在此描述的其他方式来实施,因此,本发明的保护范围并不受下面公开的具体实施例的限制。Many specific details are set forth in the following description in order to fully understand the present invention. However, the present invention can also be implemented in other ways different from those described here. Therefore, the protection scope of the present invention is not limited by the specific details disclosed below. Limitations of Examples.
为了方便理解本发明的上述技术方案,以下通过具体实施例对本发明的上述技术方案进行详细说明。In order to facilitate understanding of the above technical solutions of the present invention, the above technical solutions of the present invention will be described in detail below through specific embodiments.
如图1所示,本发明的太赫兹谱学成像釉质龋检测系统1包括:飞秒激光产生及传导单元11、太赫兹发射天线2、第一偏振太赫兹探测天线3、第二偏振太赫兹探测天线4、天线控制单元5、同步单元6、距离探测与控制单元7、光谱信号处理单元8、成像重构单元9和显示单元10。As shown in Figure 1, the terahertz spectroscopy imaging enamel caries detection system 1 of the present invention includes: femtosecond laser generation and transmission unit 11, terahertz transmitting antenna 2, first polarized terahertz detection antenna 3, second polarized terahertz Detection antenna 4, antenna control unit 5, synchronization unit 6, distance detection and control unit 7, spectral signal processing unit 8, imaging reconstruction unit 9 and display unit 10.
所述同步单元6安装在第一电路板上,光谱信号处理单元8安装在第二电路板上,所述距离探测与控制单元7安装在第三电路板上,所述飞秒激光产生及传导单元11安装在第四电路板上,所述第一电路板、第二电路板、第三电路板和第四电路板与主电路板相连。The synchronization unit 6 is installed on the first circuit board, the spectral signal processing unit 8 is installed on the second circuit board, the distance detection and control unit 7 is installed on the third circuit board, the femtosecond laser generates and conducts The unit 11 is mounted on a fourth circuit board, said first, second, third and fourth circuit boards being connected to the main circuit board.
飞秒激光产生及传导单元11:用于产生线偏振太赫兹脉冲光。Femtosecond laser generation and transmission unit 11: used to generate linearly polarized terahertz pulse light.
太赫兹发射天线2:用于对被检测牙齿发射线偏振太赫兹脉冲光。Terahertz transmitting antenna 2: used to emit linearly polarized terahertz pulse light to the tooth being detected.
第一偏振太赫兹探测天线3:用于探测透过被检测牙齿的太赫兹脉冲光。The first polarized terahertz detection antenna 3 is used to detect the terahertz pulse light that passes through the tooth to be detected.
第二偏振太赫兹探测天线4:用于探测自被检测牙齿反射的太赫兹脉冲光。The second polarized terahertz detection antenna 4 is used to detect the terahertz pulse light reflected from the tooth to be detected.
天线控制单元5:用于旋转控制太赫兹发射天线、第一偏振太赫兹探测天线和第二偏振太赫兹探测天线的方位角,以发射和探测不同线偏振方向的太赫兹脉冲光。Antenna control unit 5: used to rotate and control the azimuth angles of the terahertz transmitting antenna, the first polarized terahertz detection antenna and the second polarized terahertz detection antenna to emit and detect terahertz pulse light in different linear polarization directions.
在另一个实施例中,天线控制单位5还包括驱动器和步进电机。In another embodiment, the antenna control unit 5 also includes a driver and a stepper motor.
同步单元6:用于在旋转时保持太赫兹发射天线、第一偏振太赫兹探测天线和第二偏振太赫兹探测天线的旋转方位角相同。Synchronization unit 6: used to maintain the same rotation azimuth angle of the terahertz transmitting antenna, the first polarized terahertz detection antenna and the second polarized terahertz detection antenna during rotation.
距离探测与控制单元7:用于获取太赫兹发射天线、第一偏振太赫兹探测天线和第二偏振太赫兹探测天线至被检测牙齿表面的距离,防止发生碰撞,并计算被检测牙齿的厚度。Distance detection and control unit 7: used to obtain the distance from the terahertz transmitting antenna, the first polarized terahertz detection antenna and the second polarized terahertz detection antenna to the surface of the detected tooth, prevent collision, and calculate the thickness of the detected tooth.
在另一个实施例中,距离探测与控制单元7包括距离探测子单元和距离控制子单元,距离探测子单元探测发射天线和探测天线距离牙齿表面的距离和牙体厚度,距离控制子单元根据距离探测子单元收集的信息保持发射天线和探测天线至牙齿表面的距离恒定。In another embodiment, the distance detection and control unit 7 includes a distance detection subunit and a distance control subunit. The distance detection subunit detects the distance between the transmitting antenna and the detection antenna from the tooth surface and the tooth thickness. The distance control subunit detects the distance according to the distance. The information collected by the detection subunit keeps the distance of the transmitting antenna and the detection antenna constant from the tooth surface.
在另一个实施例中,距离探测与控制单元7所用传感器为激光或者超声传感器。In another embodiment, the sensor used by the distance detection and control unit 7 is a laser or ultrasonic sensor.
光谱信号处理单元8:用于处理第一偏振太赫兹探测天线和第二偏振太赫兹探测天线探测所得的太赫兹时域光谱信号。Spectral signal processing unit 8: used to process the terahertz time domain spectrum signals detected by the first polarized terahertz detection antenna and the second polarized terahertz detection antenna.
在另一个实施例中,所述光谱信号处理单元8处理数据的方法包括:计算峰峰值、快速傅里叶变换、计算飞行时间、计算折射率和方位角各向异性程度分析。In another embodiment, the method for processing data by the spectral signal processing unit 8 includes: calculating peak-to-peak values, fast Fourier transform, calculating time of flight, calculating refractive index, and analyzing the degree of azimuthal anisotropy.
在另一个实施例中,所述方位角各向异性程度分析为:在同一个检测位置,以一个固定角度进行同步步进旋转太赫兹发射天线、第一偏振太赫兹探测天线和第二偏振太赫兹探测天线的方位角,产生和探测不同方向的线偏振太赫兹脉冲光,记录每个方位角下的时域信号;旋转一周后,统计每个方位角下太赫兹脉冲的峰峰值,计算所有方位角中最大峰峰值和最小峰峰值的比,视为第一各向异性程度,计算所有方位角中最大峰峰值和与最大峰峰值对应方位角相正交角度的峰峰值的比,视为第二各向异性程度,计算每个方位角下最大折射率和最小折射率的比,视为第三各向异性程度。In another embodiment, the analysis of the degree of azimuthal anisotropy is as follows: at the same detection position, the terahertz transmitting antenna, the first polarized terahertz detection antenna and the second polarized terahertz detection antenna are synchronously rotated at a fixed angle. Hertz detects the azimuth angle of the antenna, generates and detects linearly polarized terahertz pulse light in different directions, and records the time domain signal at each azimuth angle; after one rotation, the peak-to-peak value of the terahertz pulse at each azimuth angle is counted, and all The ratio of the maximum peak-to-peak value and the minimum peak-to-peak value in the azimuth angle is regarded as the first degree of anisotropy. The ratio of the maximum peak-to-peak value in all azimuth angles to the peak-to-peak value at an angle orthogonal to the azimuth angle corresponding to the maximum peak-peak value is calculated, and is regarded as the first degree of anisotropy. For the second degree of anisotropy, the ratio of the maximum refractive index to the minimum refractive index at each azimuth angle is calculated, which is regarded as the third degree of anisotropy.
成像重构单元9:依据光谱信号处理单元处理所得的数据,生成被检测牙齿透射和反射多种成像数据。Imaging reconstruction unit 9: generates various imaging data of transmission and reflection of the detected tooth based on the data processed by the spectral signal processing unit.
在另一个实施例中,所述成像重构单元9生成成像数据的方法包括:峰峰值成像、飞行时间层析成像、折射率成像、频域幅值成像、频域相位成像和方位角各向异性程度成像。In another embodiment, the method for generating imaging data by the imaging reconstruction unit 9 includes: peak-to-peak imaging, time-of-flight tomography, refractive index imaging, frequency domain amplitude imaging, frequency domain phase imaging and azimuth angle imaging. Imaging of degrees of heterosexuality.
在另一个实施例中,所述方位角各向异性程度成像为:第一各项异性程度成像将第一各向异性程度作为该位置成像像素的数值大小,第二各项异性程度成像将第二各向异性程度作为该位置成像像素的数值大小,第三各向异性程度成像将第三各向异性程度作为该位置成像像素的数值大小。In another embodiment, the azimuthal anisotropy degree imaging is: the first anisotropy degree imaging uses the first anisotropy degree as the numerical size of the imaging pixel at the position, and the second anisotropy degree imaging uses the The second degree of anisotropy is used as the numerical size of the imaging pixel at this position, and the third degree of anisotropy is used as the numerical size of the imaging pixel at this position.
显示单元10:用于将成像重构单元重构的成像数据进行外部显示。Display unit 10: used to externally display the imaging data reconstructed by the imaging reconstruction unit.
采用本发明的检测系统可以实现对釉质龋的早期筛查,现提供一种检测方法如下:Early screening of enamel caries can be achieved using the detection system of the present invention. A detection method is now provided as follows:
第一步:打开检测系统,扫描患者牙齿的太赫兹透射时域信息。患龋位置的牙齿组织孔隙尺寸与太赫兹波的波长具有相似的尺度,因此会造成更强的太赫兹波散射,透射信号表现为更大的衰减,进行透射信号峰峰值成像作为表征龋病区域轮廓的重要基础。牙釉质和牙本质在太赫兹波段的折射率存在明显的差异,利用透射时域信号计算折射率进行折射率成像可以表征牙釉质和牙本质的轮廓。Step 1: Turn on the detection system and scan the terahertz transmission time domain information of the patient’s teeth. The size of the pores in the dental tissue at the site of caries is similar to the wavelength of the terahertz wave, so it will cause stronger terahertz wave scattering, and the transmission signal will show greater attenuation. Peak-to-peak imaging of the transmission signal is used to characterize the caries area. An important basis for contouring. There are obvious differences in the refractive index of enamel and dentin in the terahertz band. Using transmission time domain signals to calculate the refractive index for refractive index imaging can characterize the contours of enamel and dentin.
太赫兹透射成像:Terahertz transmission imaging:
对于待检测的患牙,扫描整颗牙齿的颊面,采集所有扫描位置的透射时域信号。使用透射信号首先区分不同的牙齿组织分布范围(主要是区分牙釉质和牙本质),再对关心的牙釉质区域做透射成像,找到釉质龋阴影。For the tooth to be detected, scan the buccal surface of the entire tooth and collect the transmission time domain signals at all scanning positions. Use transmission signals to first distinguish the distribution ranges of different tooth tissues (mainly to distinguish between enamel and dentin), and then perform transmission imaging on the enamel area of concern to find the shadow of enamel caries.
(1)折射率成像(1)Refractive index imaging
由于牙釉质和牙本质的组成成分含量不同,在时域透射信号中表现为折射率的不同,可按下式计算:Due to the different content of components of enamel and dentin, the difference in refractive index appears in the time domain transmission signal, which can be calculated as follows:
式中,ω为角频率;c为光在真空中的速度;d为牙齿厚度;为牙齿信号与参考信号的延迟时间。依据折射率的不同来区分牙釉质和牙本质的分布范围。In the formula, ω is the angular frequency; c is the speed of light in vacuum; d is the tooth thickness; is the delay time between the tooth signal and the reference signal. The distribution range of enamel and dentin is distinguished based on the difference in refractive index.
(2)透射强度成像(2) Transmission intensity imaging
对于牙釉质的区域,龋病位置与健康位置相比较,透射信号表现为强衰减,在时域透射成像中,表现为阴影暗斑,并依此初步诊断所测牙齿中是否存在早期釉质龋。For the enamel area, compared with the healthy location, the transmission signal shows strong attenuation, and in time-domain transmission imaging, it appears as a shadow dark spot, and based on this, a preliminary diagnosis is made of whether there is early enamel caries in the measured tooth.
第二步:在第一步中进行透射扫描时,同步采集反射信号,进行反射时域峰峰值成像。当牙齿内部的特征结构深度改变时,反射信号的时间延迟发生改变,利用该原理可以对反射信号分析,进行飞行时间层析成像。对反射时域信号进行傅里叶变换得到频域信号,以频率作为第三个维度进行三维成像。Step 2: During the transmission scan in the first step, the reflection signal is collected simultaneously and peak-to-peak imaging in the reflection time domain is performed. When the depth of the characteristic structure inside the tooth changes, the time delay of the reflected signal changes. This principle can be used to analyze the reflected signal and perform time-of-flight tomography. Fourier transform is performed on the reflected time domain signal to obtain the frequency domain signal, and three-dimensional imaging is performed using frequency as the third dimension.
太赫兹反射成像:Terahertz reflection imaging:
透射信号和反射信号一一对应,在重构的图像中,透射图像和反射图像的像素位置也一一对应。使用反射信号进行太赫兹飞行时间层析和频谱成像,得到牙齿内部的分层和深度信息,并进行三维重构。除了对牙齿颊面进行反射成像外,还可对咬合面进行单独的反射成像。The transmission signal and the reflection signal have a one-to-one correspondence, and in the reconstructed image, the pixel positions of the transmission image and the reflection image also have a one-to-one correspondence. Use reflected signals to perform terahertz time-of-flight tomography and spectrum imaging to obtain layering and depth information inside the teeth, and perform three-dimensional reconstruction. In addition to reflection imaging of the buccal surface of the tooth, a separate reflection imaging of the occlusal surface can be performed.
(1)反射强度成像。(1) Reflection intensity imaging.
太赫兹脉冲入射到空气/牙齿的分界面时,一部分太赫兹脉冲会透过界面,一部分会从分界面反射,还有一部分会在分界面沿不同的方向散射。龋病位置的组织孔隙尺寸与太赫兹波的波长具有相似的尺度,因此会造成更强的太赫兹波散射,反射信号相较健康位置更弱,以暗斑的形式表现在图像中。When a terahertz pulse is incident on the air/tooth interface, part of the terahertz pulse will pass through the interface, part of it will be reflected from the interface, and part of it will scatter in different directions at the interface. The size of the tissue pores at the caries site has a similar scale to the wavelength of the terahertz wave, so it will cause stronger scattering of the terahertz wave, and the reflected signal will be weaker than that at the healthy site, which will appear in the image as dark spots.
(2)太赫兹飞行时间层析。(2) Terahertz time-of-flight chromatography.
太赫兹脉冲除在空气/牙齿的分界面发生第一次反射外,若在牙齿内部的不同深度还存在其他分界面,也会发生反射。牙齿内部具有牙釉质、牙本质、牙髓等分层结构,采用飞行时间层析根据不同的反射脉冲时延,结合不同组织的折射率,可以得到牙齿内部个分层结构的深度信息,进行三维结构重建。特别的,如果釉质中存在龋病,则在健康釉质/龋病釉质和龋病釉质/健康釉质之间也会存在分界面,太赫兹脉冲会在这样的分界面处发生反射,并在三维成像中表现出来,由此可检测埋藏在健康釉质下层的龋病,并可确定其深度。In addition to the first reflection at the air/tooth interface, the terahertz pulse will also be reflected if there are other interfaces at different depths inside the tooth. The interior of the tooth has layered structures such as enamel, dentin, and pulp. Time-of-flight tomography can be used to obtain the depth information of each layered structure inside the tooth based on different reflection pulse delays and the refractive index of different tissues, and perform three-dimensional Structural reconstruction. In particular, if there is caries in the enamel, there will also be an interface between the healthy enamel/caries enamel and the carious enamel/healthy enamel. The terahertz pulse will be reflected at such an interface and be imaged in three dimensions. It manifests itself in the enamel, allowing the detection of caries buried beneath healthy enamel and determining its depth.
(3)反射频谱成像。(3) Reflection spectrum imaging.
对测得的反射信号进行傅里叶变换,将时域信号变换为频域信号。取不同频率的信号进行成像,可以提取不同频率下的响应值,由此实现三维重构。Fourier transform is performed on the measured reflection signal to transform the time domain signal into a frequency domain signal. By taking signals of different frequencies for imaging, the response values at different frequencies can be extracted, thereby achieving three-dimensional reconstruction.
第三步:对于经前两步检测得到的疑似龋病区域进行进一步的检测,天线控制单元和同步单元控制发射天线和探测天线的方位角同步旋转,即保持牙齿不动的情况下,调整太赫兹脉冲光的偏振方向,龋病位置的牙齿内部结构被破坏,对不同偏振方向的太赫兹波响应的各向异性发生变化,对健康位置可产生明显对比,进行方位角各向异性程度成像,进一步明确患龋组织的轮廓范围。与前两步的检测结果进行多源数据融合,提高诊断的准确性。Step 3: For further detection of the suspected caries area detected in the first two steps, the antenna control unit and the synchronization unit control the azimuth angles of the transmitting antenna and the detection antenna to rotate synchronously, that is, while keeping the teeth stationary, adjust too much. Due to the polarization direction of the Hertz pulse light, the internal structure of the tooth at the carious location is destroyed, and the anisotropy of the response to the terahertz waves in different polarization directions changes. It can produce significant contrast to the healthy location, and the degree of azimuthal anisotropy is imaged. Further clarify the outline of carious tissue. Multi-source data fusion is performed with the detection results of the first two steps to improve the accuracy of diagnosis.
太赫兹偏振角度依赖成像:Terahertz polarization angle-dependent imaging:
在前两步执行完毕后,较为严重的釉质龋会被有效地检出。对于部分初期的、尚不严重的龋病,图像的对比度较弱,被归类为疑似龋齿。采用太赫兹偏振角度依赖测量来进行更精细的测量,提高早期釉质龋筛查的准确性。After the first two steps are completed, more serious enamel caries will be effectively detected. For some early-stage caries that are not yet serious, the contrast of the image is weak and are classified as suspected caries. Using terahertz polarization angle-dependent measurements to make more refined measurements improves the accuracy of early enamel caries screening.
(1)釉质的各向异性检测。(1) Detection of anisotropy of enamel.
改变入射太赫兹波的偏振方向,固定间隔步长,做太赫兹脉冲的透射和反射各向异性测量。在每个测量位置都可以绘制出角度依赖图像,牙釉质若发生龋病,内部组织被破坏,角度依赖图形呈现出不规则的各向异性,可作为存在龋病的诊断指标。Change the polarization direction of the incident terahertz wave, fix the interval step size, and measure the transmission and reflection anisotropy of the terahertz pulse. An angle-dependent image can be drawn at each measurement position. If caries occurs in the enamel, the internal tissue will be destroyed, and the angle-dependent image will show irregular anisotropy, which can be used as a diagnostic indicator of the presence of caries.
(2)各向异性程度成像。(2) Anisotropic degree imaging.
利用在不同位置测得的第一各向异性程度、第二各向异性程度和第三各向异性程度作为像素值进行成像。龋病形成后,各向异性程度会出现下降,在图像中呈现暗斑。Imaging is performed using the first degree of anisotropy, the second degree of anisotropy and the third degree of anisotropy measured at different positions as pixel values. After caries develops, the degree of anisotropy decreases and dark spots appear in the image.
(3)釉质的太赫兹偏振角度依赖成像。(3) Terahertz polarization angle-dependent imaging of enamel.
以入射太赫兹波的偏振角度作为第三个维度,进行三维成像。若牙釉质范围内存在暗斑,且在不同偏振角度成像时,暗斑与周围健康釉质的对比度呈现不规律变化,可作为存在龋病的诊断指标。Three-dimensional imaging is performed using the polarization angle of the incident terahertz wave as the third dimension. If there are dark spots within the enamel, and the contrast between the dark spots and the surrounding healthy enamel changes irregularly when imaging at different polarization angles, it can be used as a diagnostic indicator of the presence of caries.
本发明提出的基于太赫兹谱学成像的釉质龋检测系统,利用太赫兹波较强的穿透性、非电离辐射特性、对龋病组织的敏感性以及龋病组织和健康组织的高对比度响应差异特性,实现了现有技术中难以做到的,对位置隐蔽、难以检测的早期釉质龋进行非电离辐射、准确、精准、直观地检测。对于初步诊断发生龋齿的位置及其周边组织,通过偏振太赫兹光对待检位置进行各向异性检测的手段,利用龋病组织和健康组织对不同偏振方向的太赫兹光激励下的各向异性响应的显著差异,结合透射式谱学成像和反射式谱学成像两种模式,在两个平移方向与频率三个维度的基础上,引入与入射太赫兹光偏振方向依赖的各向异性维度,进一步提高患龋的位置、大小和形状等的检测精度,降低误检和漏检的可能性。The enamel caries detection system based on terahertz spectroscopy imaging proposed by the present invention utilizes the strong penetrability of terahertz waves, non-ionizing radiation characteristics, sensitivity to caries tissue, and high contrast response of caries tissue and healthy tissue. The differential characteristics enable the accurate, precise and intuitive detection of early enamel caries that are hidden and difficult to detect using non-ionizing radiation, which is difficult to achieve in the existing technology. For the preliminary diagnosis of the location of dental caries and its surrounding tissue, polarized terahertz light is used to conduct anisotropic detection of the location to be examined, and the anisotropic response of the carious tissue and healthy tissue to the excitation of terahertz light with different polarization directions is used The significant difference is that by combining the two modes of transmission spectroscopy imaging and reflection spectroscopy imaging, based on the two translation directions and the three dimensions of frequency, anisotropic dimensions that are dependent on the polarization direction of the incident terahertz light are introduced to further Improve the detection accuracy of the location, size and shape of caries, and reduce the possibility of false detection and missed detection.
以上所述之实施例仅为本发明的较佳实施例,并非对本发明做任何形式上的限制。任何熟悉本领域的技术人员,在不脱离本发明技术方案范围情况下,利用上述揭示的技术内容对本发明技术方案作出更多可能的变动和润饰,或修改均为本发明的等效实施例。故凡未脱离本发明技术方案的内容,依据本发明之思路所作的等同等效变化,均应涵盖于本发明的保护范围。The embodiments described above are only preferred embodiments of the present invention and do not limit the present invention in any form. Any person familiar with the art can make more possible changes and modifications to the technical solution of the present invention using the technical content disclosed above without departing from the scope of the technical solution of the present invention, or modifications are all equivalent embodiments of the present invention. Therefore, any equivalent changes made based on the ideas of the present invention that do not deviate from the content of the technical solution of the present invention shall be covered by the protection scope of the present invention.
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