CN114397348A - Full-automatic all-in-one of liquid-transfering electrophoresis - Google Patents
Full-automatic all-in-one of liquid-transfering electrophoresis Download PDFInfo
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- CN114397348A CN114397348A CN202111620436.7A CN202111620436A CN114397348A CN 114397348 A CN114397348 A CN 114397348A CN 202111620436 A CN202111620436 A CN 202111620436A CN 114397348 A CN114397348 A CN 114397348A
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- 238000001962 electrophoresis Methods 0.000 title claims abstract description 102
- 239000007788 liquid Substances 0.000 claims abstract description 58
- 239000003153 chemical reaction reagent Substances 0.000 claims abstract description 47
- 238000005520 cutting process Methods 0.000 claims abstract description 39
- 238000004140 cleaning Methods 0.000 claims abstract description 25
- 239000003292 glue Substances 0.000 claims abstract description 16
- 238000001514 detection method Methods 0.000 claims abstract description 13
- 238000004458 analytical method Methods 0.000 claims abstract description 9
- 239000002390 adhesive tape Substances 0.000 claims abstract description 7
- 238000011084 recovery Methods 0.000 claims abstract description 7
- 230000002572 peristaltic effect Effects 0.000 claims description 18
- 239000002699 waste material Substances 0.000 claims description 13
- 238000012546 transfer Methods 0.000 claims description 8
- 230000007246 mechanism Effects 0.000 claims description 6
- 239000007921 spray Substances 0.000 claims description 4
- 238000007599 discharging Methods 0.000 claims description 2
- 239000002912 waste gas Substances 0.000 claims description 2
- 238000005507 spraying Methods 0.000 claims 1
- 239000000499 gel Substances 0.000 abstract description 18
- 238000012360 testing method Methods 0.000 abstract description 6
- 238000000246 agarose gel electrophoresis Methods 0.000 abstract description 5
- 210000003128 head Anatomy 0.000 description 15
- 239000003550 marker Substances 0.000 description 6
- 230000003760 hair shine Effects 0.000 description 5
- 238000000034 method Methods 0.000 description 5
- 239000003795 chemical substances by application Substances 0.000 description 3
- 238000011160 research Methods 0.000 description 3
- 229920000936 Agarose Polymers 0.000 description 2
- 239000012634 fragment Substances 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 150000007523 nucleic acids Chemical class 0.000 description 2
- 102000039446 nucleic acids Human genes 0.000 description 2
- 108020004707 nucleic acids Proteins 0.000 description 2
- 108010076804 DNA Restriction Enzymes Proteins 0.000 description 1
- 238000012270 DNA recombination Methods 0.000 description 1
- 238000012300 Sequence Analysis Methods 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000009585 enzyme analysis Methods 0.000 description 1
- 238000001976 enzyme digestion Methods 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 238000001502 gel electrophoresis Methods 0.000 description 1
- 238000010353 genetic engineering Methods 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000013507 mapping Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 239000002773 nucleotide Substances 0.000 description 1
- 125000003729 nucleotide group Chemical group 0.000 description 1
- 229920002401 polyacrylamide Polymers 0.000 description 1
- 238000002264 polyacrylamide gel electrophoresis Methods 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 238000005086 pumping Methods 0.000 description 1
- 230000003252 repetitive effect Effects 0.000 description 1
- 108091008146 restriction endonucleases Proteins 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 238000012795 verification Methods 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/416—Systems
- G01N27/447—Systems using electrophoresis
- G01N27/44704—Details; Accessories
- G01N27/44717—Arrangements for investigating the separated zones, e.g. localising zones
- G01N27/44721—Arrangements for investigating the separated zones, e.g. localising zones by optical means
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/28—Electrolytic cell components
- G01N27/30—Electrodes, e.g. test electrodes; Half-cells
- G01N27/38—Cleaning of electrodes
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Physics & Mathematics (AREA)
- Electrochemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
The invention discloses a full-automatic integrated machine for pipetting electrophoresis, which comprises a rack, wherein an accommodating space is formed in the rack; the electrophoresis device is arranged in the accommodating space; the rubber plate is arranged in the electrophoresis device and is provided with rubber holes; the test kit is arranged on one side of the electrophoresis device, and is provided with an indicator cavity, a reagent cavity and a reagent cavity to be detected; the output box is arranged in the accommodating space, and a plurality of adhesive tape cavities are formed in the output box; the glue cutting assembly and the liquid transferring assembly can move in the three-axis direction above the accommodating space through the three-axis moving module; the CCD detection system is used for photographing the mixed reagent and the indicator after electrophoresis and controlling the gel cutting assembly to cut the mixed reagent into strips; the invention is used for completing full-automatic sample adding, analysis, electrophoresis, gel cutting recovery and cleaning of high-flux agarose gel electrophoresis, avoids the problems that manual sample application is easy to fatigue and the position of a hole is easy to be misplaced, does not need ultraviolet irradiation for gel cutting, can prevent harm to operators, improves the accuracy and improves the working efficiency.
Description
Technical Field
The invention relates to the field of biological analysis and biomedical research, in particular to a full-automatic integrated machine for liquid transfer electrophoresis.
Background
Since agarose and polyacrylamide gel have been introduced into nucleic acid research, gel electrophoresis techniques for separating DNA by relative molecular mass have been developed as an important experimental means for analyzing and identifying DNA molecules. Agarose or polyacrylamide gel electrophoresis is one of the nuclear techniques of genetic manipulation, which can be used to isolate, identify and purify DNA fragments. The technology is simple and rapid in operation, and has become the technical basis of a plurality of general molecular biology research methods, such as DNA recombination, DNA nucleotide sequence analysis, DNA restriction enzyme analysis, restriction enzyme mapping and the like.
The existing steps of sample adding, electrophoresis, analysis, gel cutting and the like of the DNA molecules are all manually carried out in a single-step operation process, so that the operation is complex, time and labor are consumed, related errors can be caused by human factors, the whole working efficiency is low, and the actual use requirements cannot be met.
Disclosure of Invention
The invention aims to overcome the defects of the prior art and provide a full-automatic integrated machine for liquid transfer electrophoresis, which can automatically complete the full-automatic sample adding, analysis, electrophoresis, gel cutting recovery and cleaning of high-throughput agarose gel electrophoresis, improve the accuracy and have high production efficiency.
In order to achieve the purpose, the invention adopts the technical scheme that: the utility model provides a move liquid electrophoresis full-automatic all-in-one, includes:
the rack is internally provided with an accommodating space;
the electrophoresis device is arranged in the accommodating space;
the rubber plate is arranged in the electrophoresis device and provided with a plurality of rubber holes;
the detection kit is arranged on one side of the electrophoresis device, and is provided with an indicator cavity, a reagent cavity and a reagent cavity for accommodating an indicator, a reagent and a reagent to be detected;
the output box is arranged in the accommodating space, and a plurality of adhesive tape cavities for accommodating the adhesive tapes are formed in the output box;
the glue cutting assembly and the glue transferring assembly can move in the three-axis direction above the accommodating space through the three-axis moving module;
the CCD detection system is used for photographing the mixed reagent and the indicator after electrophoresis and controlling the gel cutting assembly to cut the mixed reagent into strips;
the liquid transfer assembly is used for mixing a reagent and a reagent to be detected, dispensing the mixed reagent into the glue hole, and dispensing the indicator into the glue hole; and the rubber cutting assembly is used for cutting rubber strips in the mixed reagent according to the detection result of the CCD detection system and then conveying the cut rubber strips into the rubber strip cavity.
Furthermore, the electrophoresis device comprises an electrophoresis tank, an electrophoresis liquid bin, a peristaltic pump, a waste liquid tank and an electrophoresis controller for controlling the electrophoresis tank; the electrophoresis tank is communicated with the electrophoresis liquid bin; the peristaltic pump is used for conveying the electrophoresis liquid in the electrophoresis liquid bin into the electrophoresis tank or discharging the electrophoresis liquid in the electrophoresis tank to the waste liquid bin.
Further, the rubber plate is arranged in the electrophoresis tank through a tray; the rubber plate is provided with a plurality of rows of rubber holes, and the number of the rubber holes in each row is twenty-three.
Furthermore, one side of the kit is provided with a suction head consumable box, a gel cutting head box and a waste material box.
Further, the CCD detection system comprises a CCD camera assembly, an illuminating lamp and a control system; the CCD camera shooting assembly is arranged above the electrophoresis tank; the irradiation lamp is arranged below the electrophoresis tank; after the indicator and the mixed reagent in the rubber hole are irradiated by the irradiation lamp, the indicator and the mixed reagent are shot by the CCD camera shooting assembly and then sent to the control system for analysis, and the control system drives the rubber cutting assembly to cut the mixed reagent in the rubber hole at the corresponding position.
The cleaning mechanism comprises a transverse moving module, a plurality of nozzles capable of transversely moving are arranged on the transverse moving module, and a spray liquid recovery box is arranged below the nozzles; a cleaning liquid bin communicated with the peristaltic pump is communicated with the nozzle; and the cleaning liquid bin is driven by the peristaltic pump to deliver cleaning liquid to the nozzle and then spray the cleaning liquid.
Due to the application of the technical scheme, compared with the prior art, the invention has the following advantages:
the automatic all-in-one machine before liquid transfer electrophoresis is used for completing full-automatic sample adding, analysis, electrophoresis, gel cutting recovery and cleaning of high-flux agarose gel electrophoresis, avoids the problems that manual sample application is easy to fatigue and hole sites are easy to point and misplace, gel cutting does not need ultraviolet irradiation, can prevent harm to operators, can also automatically judge the size of a strip to replace naked eyes for comparison and judgment, improves accuracy, improves working efficiency and has high popularization value.
Drawings
The technical scheme of the invention is further explained by combining the accompanying drawings as follows:
FIG. 1 is a schematic perspective view of the present invention;
FIG. 2 is an enlarged view of portion A of FIG. 1;
FIG. 3 is a schematic structural view of the present invention with the electrophoresis controller, peristaltic pump, electrophoresis tank and cleaning tank omitted;
FIG. 4 is a schematic structural diagram of the electrophoresis apparatus, the cleaning mechanism, the peristaltic pump, the electrophoresis liquid chamber and the cleaning liquid chamber;
wherein: frame 1, electrophoresis apparatus 2, offset plate 3, test agent box 4, output box 5, move liquid subassembly 6, cut gluey subassembly 7, CCD detecting system 8, wiper mechanism 9, electrophoresis tank 20, electrophoresis controller 21, electrophoresis liquid storehouse 22, peristaltic pump 23, gluey hole 30, tray 31, waste material box 50, suction head consumptive material box 60, cut gluey head box 70, nozzle 90, abandonment liquid storehouse 91, spray liquid and retrieve box 92, sideslip module 93, cleaning fluid storehouse 94.
Detailed Description
The invention is described in further detail below with reference to the figures and the embodiments. It should be understood that the specific embodiments described herein are merely illustrative of the invention and are not to be construed as limiting the invention.
Referring to fig. 1-4, a pipetting electrophoresis full-automatic all-in-one machine according to an embodiment of the present invention includes a frame 1, an electrophoresis apparatus 2, a gel plate 3, a test agent box 4, an output box 5, a pipetting assembly 6, a gel cutting assembly 7, and a CCD detection system 8; the housing 1 has a receiving space for the above components.
Referring to fig. 1 and 4, the electrophoresis apparatus 2 includes an electrophoresis tank 20 disposed in the accommodating space and a power controller 21 disposed outside the rack 1, the power controller 21 controls electrophoresis of the electrophoresis liquid in the electrophoresis tank 20, one end of the electrophoresis tank 20 is connected to a peristaltic pump 23 and an electrophoresis liquid bin 22, the peristaltic pump 23 pumps the electrophoresis liquid in the electrophoresis liquid bin 22 into the electrophoresis tank 20, and covers the rubber plate 3 in the electrophoresis tank 20; after electrophoresis is finished, the peristaltic pump 23 discharges the electrophoresis liquid in the electrophoresis tank 20 to the corresponding waste gas liquid tank 91.
The rubber plate 3 has a plurality of rows of rubber holes 30, each of which is twenty-three, wherein the rubber plate 3 is disposed inside the electrophoresis tank 20 by a support plate 31.
Referring to fig. 2, a test reagent box 4 and a suction head consumable box 60 are arranged on the left and right sides of the electrophoresis apparatus 2, the test reagent box 4 is provided with an indicator cavity for containing an indicator, a reagent and a reagent to be detected, a reagent cavity and a plurality of columns of reagent cavities to be detected, the indicator in the embodiment is a marker strip indicator, wherein each marker strip indicator can position eight strips of mixed reagent at most; a plurality of suction heads are arranged in the suction head consumable box 60, and the liquid transferring assembly 6 performs related liquid transferring work after the suction heads in the suction head consumable box 60 are adsorbed.
Two rubber cutting head boxes 70 are arranged on one side of the suction head consumable box 60 and are used for performing related operations after the rubber cutting head components 7 absorb the rubber cutting heads.
The output cassette 5 is disposed on one side of the test agent cassette 4, and has a plurality of tape chambers for accommodating the tapes in the output cassette 5.
In addition, a waste material box 50 is provided at one side of the output box 5 for collecting waste suction heads and waste cutting tips.
The pipetting assembly 6 and the gel cutting assembly 7 can correspondingly move in X, Y and Z-axis directions in the accommodating space of the rack 1 through the three-axis moving module, so that the suction of the suction head and the gel cutting head and the action of pipetting and gel cutting are facilitated.
Specifically, the liquid-moving assembly is used for conveying the reagent in the reagent cavity to the position of the reagent cavity to be detected to be mixed with the reagent to be detected, dispensing the mixed reagent into the glue hole, and simultaneously dispensing the marker strip indicator into the glue hole; the gel cutting assembly is used for cutting the mixed reagent subjected to electrophoresis by the electrophoresis device.
The cleaning mechanism 9 comprises a transverse moving module 93, four nozzles 90 capable of synchronously and transversely moving are arranged on the transverse moving module 93, and cleaning liquid remained after the nozzles 90 are sprayed is recycled below the nozzles 90; one side of the nozzle 90 is provided with a cleaning liquid bin 94 communicated with the peristaltic pump 23; in operation, the cleaning solution chamber 94 is driven by the peristaltic pump 23 to deliver cleaning solution to the nozzle 90 and then to the electrophoresis tank 220 for cleaning.
The specific work flow is as follows:
one, glue dispensing
1. The liquid transfer assembly is quickly provided with a suction head from a suction head consumable box through the triaxial transverse moving module;
2. the liquid transferring assembly sucks the reagent in the kit and then mixes the reagent into the reagent to be detected, the mixed volume is 20-30ul, the liquid transferring assembly transfers the uniformly mixed mixture into the glue hole for glue dispensing, and 80 samples are sequentially completed;
3. before the sample application of the liquid-transfering component, the peristaltic pump can be used for pumping electrophoresis liquid into the electrophoresis tank, and covering the rubber plate, and the sample can be added under the liquid surface.
4. And after dispensing, the suction head in the liquid transferring assembly is withdrawn into a waste box.
5. And the pipetting assembly is used for mounting the pipette tips from the pipette tip consumable material box again.
6 pipetting assembly into kit Maker strip indicator into designated glue well in electrophoresis tank (1 st, 10 th, 19 th column of each row, one Maker strip indicator locating eight samples at most)
And 7, after the Marker points, the pipetting assembly withdraws the suction head into the waste box.
Cutting and cleaning the strip
1. An external electrophoresis controller controls the electrophoresis liquid in the electrophoresis tank to carry out electrophoresis of 40 Min-1H; simultaneously, the rubber cutting assembly moves to a rubber cutting head box through a three-axis moving module to be provided with a rubber cutting head;
2. after electrophoresis is finished, the peristaltic pump discharges the electrophoresis liquid in the electrophoresis tank to a waste liquid barrel;
3, the CCD detection system starts to identify the Marker, cuts out corresponding strips according to the Marker value, and generates a report of corresponding data to the control system;
4. the rubber cutting assembly puts the cut strips into the accommodating holes of the output box;
5. and finally, the rubber cutting assembly retreats the rubber cutting head into a waste material box.
6. The washing mechanism washes the electrophoresis tank.
The method can be used for enzyme digestion verification, fragment separation and recovery, supercoiled proportion improvement, high-throughput nucleic acid content judgment through strip brightness and the like.
The automatic all-in-one machine before liquid transfer electrophoresis is used for completing full-automatic sample adding, analysis, electrophoresis, gel cutting recovery and cleaning of high-flux agarose gel electrophoresis, avoids the problems that manual sample application is easy to fatigue and hole sites are easy to point and misplace, gel cutting does not need ultraviolet irradiation, can prevent harm to operators, can also automatically judge the size of a strip instead of human eyes for comparison and judgment, improves accuracy, improves working efficiency and has high popularization value.
The above is only a specific application example of the present invention, and the protection scope of the present invention is not limited in any way. All the technical solutions formed by equivalent transformation or equivalent replacement fall within the protection scope of the present invention.
Claims (6)
1. The utility model provides a move liquid electrophoresis full-automatic all-in-one which characterized in that includes:
the rack is internally provided with an accommodating space;
the electrophoresis device is arranged in the accommodating space;
the rubber plate is arranged in the electrophoresis device and provided with a plurality of rubber holes;
the detection kit is arranged on one side of the electrophoresis device, and is provided with an indicator cavity, a reagent cavity and a reagent cavity for accommodating an indicator, a reagent and a reagent to be detected;
the output box is arranged in the accommodating space, and a plurality of adhesive tape cavities for accommodating the adhesive tapes are formed in the output box;
the glue cutting assembly and the glue transferring assembly can move in the three-axis direction above the accommodating space through the three-axis moving module;
the CCD detection system is used for photographing the mixed reagent and the indicator after electrophoresis and controlling the gel cutting assembly to cut the mixed reagent into strips;
the liquid transfer assembly is used for mixing a reagent and a reagent to be detected, dispensing the mixed reagent into the glue hole, and dispensing the indicator into the glue hole; and the rubber cutting assembly is used for cutting rubber strips in the mixed reagent according to the detection result of the CCD detection system and then conveying the cut rubber strips into the rubber strip cavity.
2. The pipette electrophoresis fully automated all-in-one machine of claim 1, wherein: the electrophoresis device comprises an electrophoresis tank, an electrophoresis liquid bin, a peristaltic pump, a waste liquid tank and an electrophoresis controller for controlling the electrophoresis tank; the electrophoresis tank is communicated with the electrophoresis liquid bin; the peristaltic pump is used for conveying the electrophoresis liquid in the electrophoresis liquid bin into the electrophoresis tank, or discharging the electrophoresis liquid in the electrophoresis tank to the waste gas liquid tank.
3. The pipette electrophoresis fully automated all-in-one machine of claim 1, wherein: the rubber plate is arranged in the electrophoresis tank through a tray; the rubber plate is provided with a plurality of rows of rubber holes, and the number of the rubber holes in each row is twenty-three.
4. The pipette electrophoresis fully automated all-in-one machine of claim 1, wherein: one side of the kit is provided with a suction head consumable box, a gel cutting head box and a waste material box.
5. The pipette electrophoresis fully automated all-in-one machine of claim 1, wherein: the CCD detection system comprises a CCD camera shooting assembly, an illuminating lamp and a control system; the CCD camera shooting assembly is arranged above the electrophoresis tank; the irradiation lamp is arranged below the electrophoresis tank; after the indicator and the mixed reagent in the rubber hole are irradiated by the irradiation lamp, the indicator and the mixed reagent are shot by the CCD camera shooting assembly and then sent to the control system for analysis, and the control system drives the rubber cutting assembly to cut the mixed reagent in the rubber hole at the corresponding position.
6. The pipette electrophoresis fully automated all-in-one machine of claim 1, wherein: the cleaning mechanism comprises a transverse moving module, a plurality of nozzles capable of transversely moving are arranged on the transverse moving module, and a spraying liquid recovery box is arranged below the nozzles; a cleaning liquid bin communicated with the peristaltic pump is communicated with the nozzle; and the cleaning liquid bin is driven by the peristaltic pump to deliver cleaning liquid to the nozzle and then spray the cleaning liquid.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202111620436.7A CN114397348A (en) | 2021-12-28 | 2021-12-28 | Full-automatic all-in-one of liquid-transfering electrophoresis |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202111620436.7A CN114397348A (en) | 2021-12-28 | 2021-12-28 | Full-automatic all-in-one of liquid-transfering electrophoresis |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN114397348A true CN114397348A (en) | 2022-04-26 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202111620436.7A Pending CN114397348A (en) | 2021-12-28 | 2021-12-28 | Full-automatic all-in-one of liquid-transfering electrophoresis |
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Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1242076A (en) * | 1996-11-29 | 2000-01-19 | 牛津糖科学(英国)有限公司 | Gel, method and apparatus for biomolecule identification and characterization |
| CN206089656U (en) * | 2016-10-08 | 2017-04-12 | 郑州伊美诺生物技术有限公司 | Platform is surely glued to real -time observation of nucleic acid electrophoresis |
| CN109628554A (en) * | 2018-11-16 | 2019-04-16 | 上海爪鸽医药科技有限公司 | A kind of nucleic acid gel extraction automatic method based on image recognition |
| CN112904033A (en) * | 2021-03-29 | 2021-06-04 | 水熊健康科技(南通)有限公司 | Full-automatic high-throughput single-cell immunoblotting instrument device |
| CN214637845U (en) * | 2021-03-02 | 2021-11-09 | 温州领纳电子有限公司 | Trace automatic control point gum machine with self-cleaning mechanism |
| CN215297236U (en) * | 2021-06-11 | 2021-12-24 | 青岛奇点生物有限公司 | Automatic change point and glue electrophoresis gel cutter |
-
2021
- 2021-12-28 CN CN202111620436.7A patent/CN114397348A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1242076A (en) * | 1996-11-29 | 2000-01-19 | 牛津糖科学(英国)有限公司 | Gel, method and apparatus for biomolecule identification and characterization |
| CN206089656U (en) * | 2016-10-08 | 2017-04-12 | 郑州伊美诺生物技术有限公司 | Platform is surely glued to real -time observation of nucleic acid electrophoresis |
| CN109628554A (en) * | 2018-11-16 | 2019-04-16 | 上海爪鸽医药科技有限公司 | A kind of nucleic acid gel extraction automatic method based on image recognition |
| CN214637845U (en) * | 2021-03-02 | 2021-11-09 | 温州领纳电子有限公司 | Trace automatic control point gum machine with self-cleaning mechanism |
| CN112904033A (en) * | 2021-03-29 | 2021-06-04 | 水熊健康科技(南通)有限公司 | Full-automatic high-throughput single-cell immunoblotting instrument device |
| CN215297236U (en) * | 2021-06-11 | 2021-12-24 | 青岛奇点生物有限公司 | Automatic change point and glue electrophoresis gel cutter |
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