CN114376940A - Amino acid ice crystal shower gel and preparation method thereof - Google Patents
Amino acid ice crystal shower gel and preparation method thereof Download PDFInfo
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- CN114376940A CN114376940A CN202210156049.0A CN202210156049A CN114376940A CN 114376940 A CN114376940 A CN 114376940A CN 202210156049 A CN202210156049 A CN 202210156049A CN 114376940 A CN114376940 A CN 114376940A
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- amino acid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/736—Chitin; Chitosan; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
- A61K8/447—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof containing sulfur
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/10—Washing or bathing preparations
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- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Cosmetics (AREA)
Abstract
The invention relates to amino acid ice crystal shower gel which comprises the following components in parts by weight: 10-20 parts of anionic surfactant, 10-20 parts of zwitterionic surfactant, 5-10 parts of amino acid, 6-8 parts of acrylate copolymer, 0.5-1.5 parts of liquid alkali, 6-8 parts of modified hydroxypropyl chitosan, an auxiliary agent and water. The modified hydroxypropyl chitosan is chemically modified on the basis of hydroxypropyl chitosan, so that amino acid groups are connected to the hydroxypropyl chitosan. The modified hydroxypropyl chitosan has strong water absorption and moisture retention capacity, promotes the dissolution of amino acid components, and improves the performance of the product. The amino acid ice crystal shower gel provided by the invention has an obvious improvement effect on skin water content.
Description
Technical Field
The invention relates to the technical field of daily chemical products, and particularly relates to amino acid ice crystal shower gel and a preparation method thereof.
Background
The amino acid is a basic composition unit of protein and an important composition part of a human body, and sufficient amino acid not only can ensure the requirement of the human body on the protein, but also can be converted into other nutrient substances such as saccharides, fat and the like, so that the requirement of the human body on other nutrients is met, and the amino acid plays an important role in maintaining the normal health of the human body.
Meanwhile, amino acid also has important influence on skin, and the amino acid can enhance the immune function of the skin, adjust the moisture and the pH value in the skin and balance surface grease. The amino acid can improve the anti-allergy capability of sensitive skin, and can generate a chelation reaction with divalent metal ions in the skin to prevent excessive divalent metal ions from generating a crosslinking effect with collagen in the skin, so that enough collagen fibers and elastic fibers are maintained, the skin is kept smooth, fine and elastic, and wrinkles are prevented from being generated. Amino acids also have the function of enhancing the lymphatic system, which can improve the skin's anti-allergic ability and metabolize aging cells in the body, so amino acids are essential substances for skin health.
Therefore, many manufacturers apply amino acids to personal care products, such as shampoo, bath lotion, etc., to achieve the effects of keeping skin moist and smooth, promoting cell regeneration and metabolism, and resisting aging and wrinkling. And moreover, the proper amount of the amino acid is added, so that the product has an ice crystal effect, and the added value of the product is further improved.
However, due to the influence of temperature change or storage time, the amino acid ice crystal bath cream product is easy to have the phenomena of agglomeration, bottom sinking and non-uniformity, so that the amino acid is difficult to be fully dissolved and cannot be absorbed by the skin in actual use, and the surfactant in the bath cream can wash away most of grease and cutin on the surface of the skin, so that the skin becomes drier, even wrinkles and cracks easily, the skin health is damaged, the moisturizing and moistening effects of the product are greatly reduced, and the experience of consumers is greatly reduced.
Therefore, the development of a novel amino acid ice crystal shower gel capable of effectively improving the moisturizing effect of the product is urgently needed to solve the defects existing in the product and meet the use requirements of consumers.
Disclosure of Invention
The invention aims to provide amino acid ice crystal shower gel aiming at the defects of the prior art. The amino acid ice crystal shower gel contains the humectant, so that the moisturizing effect of the shower gel is enhanced. It is worth mentioning that the humectant is prepared by chemically modifying hydroxypropyl chitosan on the basis of the hydroxypropyl chitosan, so that amino acid groups are connected to the hydroxypropyl chitosan. The modified hydroxypropyl chitosan is used as a biological macromolecule, has strong water absorption and moisture retention capacity, and improves the water retention performance of the product; in addition, the amino acid group has certain polarity, is similar to the amino acid structure, is favorable for solubilizing the amino acid group, and further improves the performance of the product.
The invention aims to provide an amino acid ice crystal shower gel which comprises the following components in parts by weight:
auxiliary agent
Water;
wherein, the modified hydroxypropyl chitosan has the following structural general formula:
wherein, R is1Is an amino acid group;
and n is an integer.
The modified hydroxypropyl chitosan can form linear chain polycation after being dissolved, has good film forming property, can effectively absorb moisture in the environment, can also be adsorbed on keratin and lipid, continuously acts on the inner layer of the skin, is combined with free water, reduces the evaporation capacity of the skin, and has good moisturizing performance; the modified hydroxypropyl chitosan is a biological macromolecule, and a large amount of free amino and hydroxypropyl exist in the modified hydroxypropyl chitosan, so that the modified hydroxypropyl chitosan has good solubility and biocompatibility, can be filled in dry cracks on the surface of skin and acts with ceramide in a surface sebum membrane layer to generate a chitosan glycolipid membrane layer, and is finally integrated with the epidermis to achieve the effects of moistening and caring the skin.
Further, the amino acid is selected from one or more of aspartic acid, leucine, methionine, glutamic acid, glycine, histidine, asparagine and glutamine.
Further, the anionic surfactant is selected from one or more of AOS, AES, MES and AEC.
Further, the zwitterionic surfactant is selected from one or more of amino acid type surfactant, amine oxide type surfactant, betaine type surfactant and imidazoline type surfactant.
Further, said R1One or more selected from the group consisting of a tryptophan group, a methionine group, a threonine group, a valine group, a lysine group, a histidine group, a leucine group, an isoleucine group, an alanine group, a phenylalanine group, a cystine group, a cysteine group, an arginine group, a glycine group, a serine group, a tyrosine group, a glutamic acid group, an aspartic acid group, a proline group, a hydroxyproline group, a citrulline group, an ornithine group.
Further, the auxiliary agent is selected from one or more of preservative, essence, EDTA disodium and citric acid.
The invention also aims to provide a preparation method of the amino acid ice crystal shower gel, which comprises a preparation method of modified hydroxypropyl chitosan, wherein the preparation method of the modified hydroxypropyl chitosan comprises the following steps:
s1, adding amino acid into MES buffer solution containing NHS and EDC, and reacting to obtain mixed solution 1;
s2, adding the mixed solution 1 into MES buffer solution containing hydroxypropyl chitosan, and reacting to obtain a mixed solution 2;
and S3, adjusting the pH value of the mixed solution 2, and dialyzing to obtain the modified hydroxypropyl chitosan.
Further, in step S1, the molar ratio of the amino acid, NHS and EDC is (1-2):4: 4.
Further, in step S2, the reaction time is 24-30 h.
Further, in step S3, the pH value is 8-9.
Compared with the prior art, the invention has the following beneficial effects:
the invention discloses amino acid ice crystal shower gel, which takes modified hydroxypropyl chitosan as a humectant, on one hand, the modified hydroxypropyl chitosan has strong affinity with skin cells, high solubility and good water absorption and moisture retention performances, improves the moisture retention effect of the amino acid ice crystal shower gel, and ensures the health of skin; on the other hand, the modified hydroxypropyl chitosan contains amino acid groups, has certain polarity, is beneficial to dissolving amino acid components in the shower gel, effectively avoids the phenomena of amino acid agglomeration and caking, ensures that ice crystals are stably suspended in the formula composition, does not have the condition of flocculence or sinking, and promotes the absorption of the amino acid ice crystals by skin.
Detailed Description
In order to more clearly illustrate the technical solution of the present invention, the following examples are given, but the present invention is not limited thereto.
The experimental methods used in the following examples are all conventional methods unless otherwise specified; reagents, materials and the like used in the following examples are commercially available unless otherwise specified.
The anionic surfactant in the embodiment of the invention is MES 30 lauryl polyether succinate disodium produced by Shihuasha company and AES lauryl alcohol ether sulfate sodium produced by Zanyu company.
The zwitterionic surfactants in the examples of this invention were SUR LMA 30 sodium lauroyl methylaminopropionate from Shihuasha and CAPB 35 cocamidopropyl betaine from Hede.
The acrylate copolymer in the examples of the present invention was SF-1 produced by Hede corporation.
The preservative in the embodiment of the invention is 9010 produced by Shumei company.
Hydroxypropyl chitosan in the embodiment of the invention is purchased from east Xin biotechnology limited company in Jingmen city, and has a molecular weight of about 12 ten thousand.
The dialysis bag in the embodiment of the invention is a regenerated cellulose dialysis bag produced by Germany Bayer.
The sodium hyaluronate in the comparative example of the invention is sodium hyaluronate produced by Huaxi Furazida biological medicine Limited.
The modified hydroxypropyl chitosan in the embodiment of the invention is synthesized by the inventor, and the structure of the modified hydroxypropyl chitosan is as follows:
wherein, R is1Is a methionine group.
The synthesis steps of the modified hydroxypropyl chitosan are as follows:
s1, adding methionine into MES buffer solution (with MES concentration of 25mmol/L, pH of 4.5 and mol ratio of methionine, NHS and MES of 1:4:4) containing NHS and EDC, and reacting for 2h to obtain mixed solution 1;
s2, adding the mixed solution 1 into MES buffer solution containing hydroxypropyl chitosan (with the MES concentration of 25mmol/L, the pH value of 4.5 and the mass ratio of hydroxypropyl chitosan to methionine of 1:1 in the step S1), reacting for 24 hours, adding 25mg of hydroxylamine hydrochloride to terminate the reaction, and obtaining mixed solution 2;
s3, adjusting the pH value of the mixed solution 2 to 9 by using 32 wt% of liquid alkali, and filling the mixed solution into a dialysis bag for dialysis for 48 hours to obtain the modified hydroxypropyl chitosan with ideal molecular weight.
The ingredients and corresponding parts by mass of the amino acid ice crystal shower gel of examples 1-3 are shown in table 1.
TABLE 1 EXAMPLES 1-3 amino acid ice crystal bath lotion ingredients and parts by weight thereof
The preparation methods of examples 1 to 3 were all as follows: adding water, MES 30 and EDTA-disodium into the main stirring kettle in parts by weight, and stirring until the materials are completely dissolved; then heating to 80 ℃, adding AES, SUR LMA 30, CAPB 35 and amino acid, and uniformly stirring; then cooling to 70 ℃, adding SF-1, uniformly mixing, adding liquid alkali, and stirring for 30min until the mixture is transparent; and finally, cooling to 50 ℃, and adding 9010, essence and modified hydroxypropyl chitosan to obtain the amino acid ice crystal shower gel product.
A comparative example thereof was set based on example 1. The ingredients of the comparative examples are shown in table 2.
Table 2 components and parts by mass of amino acid ice crystal shower gel of comparative examples 1-3 and comparative examples 1-3
The preparation methods of comparative examples 1 to 3 are different from example 1 in that: the modified hydroxypropyl chitosan component was replaced or deleted accordingly, and the other steps were the same as in example 1.
Test example section
Test example 1 stability test
The test method comprises the following steps:
the stability tests were carried out on the amino acid ice crystal shower gels prepared in examples 1 to 3 and comparative examples 1 to 3, and the specific test methods were as follows:
high-temperature stability: and (3) taking 200ml of the shower gel, filling the shower gel into a transparent container, sealing, placing in an environment with the temperature of 40 +/-1 ℃, standing at constant temperature for 1 month, and observing the appearance of the shower gel.
Low-temperature stability: and (3) taking 200ml of the shower gel, filling the shower gel into a transparent container, sealing, placing in an environment with the temperature of 0 +/-2 ℃, standing at constant temperature for 1 month, and observing the appearance of the shower gel.
And (3) testing results:
TABLE 3 stability tests of examples 1-3 and comparative examples 1-3
As can be seen from Table 3, compared with the comparative examples, the high temperature stability of examples 1 to 3 of the present invention is good, no delamination or precipitation occurs, and the ice crystals are uniformly suspended in the product; and certain crystals are precipitated at low temperature, but the crystal precipitation is still obviously superior to that of comparative examples 1-3, so that the modified hydroxypropyl chitosan added in the invention has the function of stabilizing amino acid components in the formula.
Test example 2 moisturizing effect test
The test method comprises the following steps:
20 persons with abundant test experience in the experimental center were divided into four groups, 5 persons in each group, and the body wash prepared in example 1 and comparative examples 1-3 was tried on each group, each person evenly smeared 3g of the body wash on a 3cm x 3cm area of forearm skin, gently rubbed the skin for about 2min, then quickly rinsed with water, measured the skin water content of the upper skin area before use, after use for 0.5h and after use for 1h with an SD-g7 skin water and oil content tester manufactured by precision instruments factory in Shanghai, and the average value of each group of time periods was calculated.
And (3) testing results:
table 4 test results of moisturizing effect of body wash
As can be seen from table 4, the amino acid ice crystal shower gel prepared in example 1 of the present invention has strong moisture retention performance because it contains the modified hydroxypropyl chitosan component, which can effectively absorb moisture and adsorb on skin cells; meanwhile, the modified hydroxypropyl chitosan promotes the dissolution and absorption of amino acid components, so that the moisturizing capability is further improved, the water content of the skin is effectively improved, the skin can be kept for a long time, and the moisturizing effect of the modified hydroxypropyl chitosan is better than that of the comparative example 2 using the conventional moisturizing agent sodium hyaluronate. While comparative example 1 in which unmodified hydroxypropyl chitosan was added and comparative example 3 in which only the amino acid component was contained were significantly poor in moisturizing property to the skin and also poor in durability.
It will be evident to those skilled in the art that the invention is not limited to the details of the foregoing illustrative embodiments, and that the present invention may be embodied in other specific forms without departing from the spirit or essential attributes thereof. The present embodiments are therefore to be considered in all respects as illustrative and not restrictive, the scope of the invention being indicated by the appended claims rather than by the foregoing description, and all changes which come within the meaning and range of equivalency of the claims are therefore intended to be embraced therein.
Furthermore, it should be understood that although the present description refers to embodiments, not every embodiment may contain only a single embodiment, and such description is for clarity only, and those skilled in the art should integrate the description, and the embodiments may be combined as appropriate to form other embodiments understood by those skilled in the art.
Claims (10)
1. The amino acid ice crystal shower gel is characterized by comprising the following components in parts by weight:
auxiliary agent
Water;
wherein, the modified hydroxypropyl chitosan has the following structural general formula:
wherein, R is1Is an amino acid group and derivatives thereof;
and n is an integer.
2. The amino acid ice crystal shower gel of claim 1, wherein the amino acid is selected from one or more of aspartic acid, leucine, methionine, glutamic acid, glycine, histidine, asparagine, and glutamine.
3. The amino acid ice crystal shower gel of claim 1 wherein said anionic surfactant is selected from one or more of AOS, AES, MES, AEC.
4. The amino acid ice crystal shower gel of claim 1, wherein the zwitterionic surfactant is selected from one or more of an amino acid type surfactant, an amine oxide type surfactant, a betaine type surfactant, and an imidazoline type surfactant.
5. The amino acid ice crystal shower gel of claim 1, wherein R is1One or more selected from the group consisting of a tryptophan group, a methionine group, a threonine group, a valine group, a lysine group, a histidine group, a leucine group, an isoleucine group, an alanine group, a phenylalanine group, a cystine group, a cysteine group, an arginine group, a glycine group, a serine group, a tyrosine group, a glutamic acid group, an aspartic acid group, a proline group, a hydroxyproline group, a citrulline group, an ornithine group.
6. The amino acid ice crystal shower gel of claim 1, wherein the adjuvant is selected from one or more of preservatives, flavors, disodium EDTA, and citric acid.
7. The preparation method of the amino acid ice crystal shower gel as claimed in any one of claims 1 to 6, which comprises the preparation method of modified hydroxypropyl chitosan, wherein the preparation method of the modified hydroxypropyl chitosan comprises the following steps:
s1, adding amino acid into MES buffer solution containing NHS and EDC, and reacting to obtain mixed solution 1;
s2, adding the mixed solution 1 into MES buffer solution containing hydroxypropyl chitosan, and reacting to obtain a mixed solution 2;
and S3, adjusting the pH value of the mixed solution 2, and dialyzing to obtain the modified hydroxypropyl chitosan.
8. The method for preparing the amino acid ice crystal bath cream according to claim 7, wherein in step S1, the molar ratio of the amino acid, NHS and EDC is (1-2):4: 4.
9. The method for preparing the amino acid ice crystal bath cream according to claim 7, wherein in the step S2, the reaction time is 24-30 h.
10. The method for preparing an amino acid ice crystal bath cream according to claim 7, wherein the pH value is 8-9 in step S3.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN114948827A (en) * | 2022-05-09 | 2022-08-30 | 佛山嘿黑科技有限公司 | Selenium-rich rice washing water shampoo and preparation method thereof |
| CN115645316A (en) * | 2022-07-07 | 2023-01-31 | 全芯生物科技(澳门)有限公司 | Anti-hair loss shampoo containing rosemary |
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| CN104606071A (en) * | 2015-02-06 | 2015-05-13 | 深圳唯美度生物科技有限公司 | Facial cleanser for effectively preventing haze hazards |
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| CN114948827A (en) * | 2022-05-09 | 2022-08-30 | 佛山嘿黑科技有限公司 | Selenium-rich rice washing water shampoo and preparation method thereof |
| CN114948827B (en) * | 2022-05-09 | 2023-08-15 | 广州乐信生物科技有限公司 | Selenium-enriched rice washing liquid shampoo and preparation method thereof |
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| CN115645316B (en) * | 2022-07-07 | 2023-09-29 | 全芯生物科技(澳门)有限公司 | Anti-hair loss shampoo containing rosemary |
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