CN114344134A - Nasal obstruction prevention and treatment device combining endogenous nitric oxide and exogenous nitric oxide and using method thereof - Google Patents
Nasal obstruction prevention and treatment device combining endogenous nitric oxide and exogenous nitric oxide and using method thereof Download PDFInfo
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- CN114344134A CN114344134A CN202111658258.7A CN202111658258A CN114344134A CN 114344134 A CN114344134 A CN 114344134A CN 202111658258 A CN202111658258 A CN 202111658258A CN 114344134 A CN114344134 A CN 114344134A
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Abstract
The invention provides a nasal obstruction prevention and treatment device combining endogenous nitric oxide and exogenous nitric oxide and a using method thereof, wherein the nasal obstruction prevention and treatment device comprises a shell with a breathing port, and an NO generation module and a sound wave vibration module are arranged in the shell; the NO generation module comprises a light source and an NO generation chip, the NO generation chip is excited to generate NO gas after being irradiated by the light source, and the patient inhales the NO gas and then carries out nasal obstruction treatment from an external source; the sound waves generated by the sound wave vibration module vibrate the nose of the patient, and nasal obstruction treatment is performed from an internal source. The invention comprehensively treats the problem of the nasal obstruction by inputting NO from an external source and vibrating sound waves from an internal source, adaptively adjusts the release speed of NO and the release concentration of NO by adjusting the illumination time, the wavelength of a light source and the illumination intensity, and adaptively adjusts the frequency, the waveform and the like of the vibrating sound waves by the sound wave vibration module so as to realize the internal and external source combined treatment of the nasal obstruction and achieve the optimal effects of treatment and defense.
Description
Technical Field
The invention belongs to the technical field of medical equipment, and relates to a nasal obstruction prevention and treatment device combining endogenous nitric oxide and exogenous nitric oxide and a using method thereof.
Background
Nasal obstruction is the sensation of blocked nasal cavity with poor ventilation or poor ventilation. Nasal obstruction is one of the common symptoms of nasal cavity, and the main causes of nasal obstruction include rhinitis, sinusitis, inflammation of nasal mucosa, and the like.
Rhinitis refers to inflammation of nasal mucosa, manifested as congestion or edema, which often causes symptoms such as nasal obstruction, watery nasal discharge, and nasal itching. The treatment mode of rhinitis causing nasal obstruction in patients is related to the type of rhinitis, and because different types of rhinitis cause nasal obstruction to different degrees, and the related treatment methods are different, the common conditions include: (1) acute rhinitis: typical symptoms caused by viral or bacterial infection of the upper respiratory tract include nasal obstruction, sneezing, headache, hyposmia, and watery nasal discharge, i.e. clear or sticky nasal discharge. The treatment mainly comprises nasal spray hormone and decongestant, and Chinese patent medicine and antiviral medicine for treating rhinitis by systemic oral administration; (2) chronic rhinitis: for chronic simple rhinitis, patients can use drug therapy, including decongestants, nasal spray hormones; aiming at chronic hypertrophic rhinitis, a patient can use a medicament for treatment, and if the treatment is ineffective, a surgical treatment method can be adopted, such as inferior turbinate partial excision, low-temperature plasma radio frequency ablation and laser operation, so as to relieve nasal obstruction symptoms; allergic rhinitis needs to be treated by allergen, and patients can be treated by nasal spray hormone and antiallergic oral drugs.
The nasal obstruction caused by nasosinusitis is a clinical manifestation caused by that the nasal mucosa is stimulated by inflammation, so that the nasal mucosa is swollen, and the nasal cavity becomes narrow.
CN113368357A discloses breathe nasal plug formula treatment device for internal medicine, including oxygen therapy mechanism, fixed establishment and coupling mechanism, fixed establishment sets up in oxygen therapy mechanism, and coupling mechanism sets up in oxygen therapy mechanism bottom, and oxygen therapy mechanism includes two-way screwed pipe and oxygen therapy pipe, and oxygen therapy pipe is provided with two altogether, and every oxygen therapy pipe surface is close to one end edge and all overlaps and is equipped with the connecting pipe, and every connecting pipe top is close to central department and all slides and inlay and be equipped with the air duct. In this scheme, pass the oxygen therapy pipe behind the patient's ear, be connected with two fixed blocks through fixture block and draw-in groove firmly simultaneously and remove regulation fixed block position, and then effectively insert inside back in patient's nostril as the air duct, remove the fixed block position, and then make equipment can stabilize and wear at patient's face, can outwards take out the locating lever according to patient's in-service use condition simultaneously, and then through rotatory back shaft, can make the back shaft drive the supporting wheel to the connecting pipe inside or to the outside air duct that removes of connecting pipe.
CN213724479U discloses rhinitis appearance that facilitates use in rhinitis appearance technical field, including nasal obstruction module and control module, one side swing joint of nasal obstruction module has a plurality of swing joint rings, the treatment head can be dismantled to fixedly connected with on the swing joint ring, can dismantle and be equipped with the optical fiber in the treatment head, fixed mounting has miniature power in the nasal obstruction module, one side fixed mounting that miniature power is close to swing joint ring has the information receiving module, one side fixed mounting that miniature power was kept away from to the information receiving module has heating module, one side fixed mounting that information receiving module was kept away from to the heating module has treatment light source, treatment light source is close to one side fixed mounting that can dismantle the treatment head has ultraviolet isolator, first groove that charges has been seted up to nasal obstruction module one side, first groove and miniature power electric connection charge.
CN205127034U discloses internal medicine suction therapy device, which comprises a host computer, be equipped with the air purification appearance at the host computer upside, be equipped with the humidifier on the air purification appearance, be equipped with the release hole on the humidifier, the air purification appearance right side is equipped with control switch, the thermometer right side is equipped with room temperature inductor, room temperature inductor right side is equipped with into nasal gas treater, it is equipped with medicine storage pipe to go into nasal gas treater upside, medicine storage pipe upside is equipped with the injection entry, medicine storage pipe front side is equipped with gaseous change over switch, it is equipped with shift knob to go into nasal gas treater front side.
In summary, conventional nasal congestion treatments provide only partial and/or temporary relief and sometimes have adverse side effects; the sound shock treatment can open the nasal sinus mouth to release NO in a short time, but neglects the prevention work that the nasal sinus is easily infected by bacteria, viruses and the like.
Disclosure of Invention
Aiming at the defects of the prior art, the invention aims to provide a nasal obstruction prevention and treatment device combining endogenous nitric oxide and exogenous nitric oxide and a using method thereof, the invention comprehensively treats the problem of nasal obstruction by inputting NO from an external source and vibrating sound waves from the endogenous source, can help to recover and enhance mucociliary function after NO gas enters a nasal cavity, enhances the defense capability to chronic colonizing pathogens, reduces or even prevents the continuation of diseases, the NO release speed and the NO release concentration are adaptively adjusted by adjusting the illumination time, the light source wavelength and the illumination intensity, thereby being capable of pertinently providing corresponding NO gas treatment for different people of different ages, sexes and symptoms, in addition, the frequency, the waveform and the like of the vibration sound waves are adaptively adjusted by matching with the sound wave vibration module, so that endogenous treatment of the nasal obstruction is realized, and the optimal treatment and defense effects are achieved.
In order to achieve the purpose, the invention adopts the following technical scheme:
in a first aspect, the present invention provides a nasal obstruction control device that combines endogenous and exogenous nitric oxide, the nasal obstruction control device comprising a housing having a breathing orifice that, in use, covers a patient's nose;
the NO generation module and the sound wave vibration module are arranged in the shell; the NO generation module comprises a light source and an NO generation chip, the NO generation chip is excited to generate NO gas after being irradiated by the light source, and the patient inhales the NO gas and then carries out nasal obstruction treatment from an external source; the sound waves generated by the sound wave vibration module vibrate the nose of the patient, and nasal obstruction treatment is performed from an internal source.
The nasal obstruction treatment device comprehensively treats the problem of nasal obstruction by inputting NO from an external source and carrying out sound wave vibration from an internal source, can help to recover and enhance mucociliary function after NO gas enters a nasal cavity, enhances the defense capability to chronic colonized pathogens, reduces or even prevents the continuation of diseases, and carries out adaptive adjustment on the release speed of NO and the release concentration of NO by adjusting illumination time, light source wavelength and illumination intensity, so that corresponding NO gas treatment can be provided for different people of different ages, sexes and symptoms.
As a preferable technical solution of the present invention, the nasal obstruction control device includes a nasal inhalation mode and a nasal exhalation mode.
Preferably, a one-way inhalation valve and a one-way exhalation valve are arranged on the casing.
Preferably, in the nasal inhalation mode, the one-way inhalation valve is opened, and simultaneously the one-way exhalation valve is closed, and air in the external environment enters the shell through the one-way inhalation valve to supply oxygen to the patient.
Preferably, in the nasal exhalation mode, the one-way inhalation valve is closed while the one-way exhalation valve is open, and the gas exhaled by the patient is discharged through the one-way exhalation valve.
Preferably, the one-way inhalation valve and the one-way exhalation valve are located on the casing close to the breathing port, the one-way inhalation valve and the one-way exhalation valve are arranged oppositely, and when the one-way inhalation valve is used, the one-way inhalation valve is located below, and the one-way exhalation valve is located above.
Preferably, the breathing hole is provided with a breathing mask, and when the mask is used, the nose of a patient is covered by the breathing mask.
As a preferred technical scheme of the invention, the exogenous nitric oxide treatment is carried out by the light source and the NO generating chip in the nasal inhalation mode.
Preferably, the light source includes a blue light, a green light, and a blue light.
Preferably, the emission wavelength range of the Bao blue lamp is 450-455 nm, such as 450nm, 451nm, 452nm, 453nm, 454nm or 455nm, but not limited to the values listed, and other values not listed in the range are also applicable.
Preferably, the green light has an emission wavelength in the range of 570-575 nm, such as 570nm, 571nm, 572nm, 573nm, 574nm or 575nm, but not limited to the values listed, and other values not listed in the range of values are equally applicable.
Preferably, the blue light has an emission wavelength in the range of 460 to 470nm, such as 460nm, 461nm, 462nm, 463nm, 464nm, 465nm, 466nm, 467nm, 468nm, 469nm or 470nm, but not limited to the recited values, and other values not recited in the range of values are also applicable.
It should be noted that the light source provided by the present invention is preferably a spherical light source, and the adoption of the spherical light source can ensure the uniform dispersion of the light wave to the maximum extent, so that the effective release rate of the NO generation chip is the highest. The NO generation chip is respectively irradiated by three light sources with different light-emitting wavelengths, and the concentration and the release rate of NO which is excited and released by the NO generation chip under different wavelengths are different; specifically, the method comprises the following steps: after the Bao blue lamp irradiates the NO generation chip within the wavelength range of 450-455, the NO can be rapidly released within a short time to reach higher NO concentration, the NO release rate is 0.84ug/min, and the NO release concentration can reach 0.98ppm at most. After the green lamp irradiates the NO generation chip within the wavelength range of 570-575 nm, the antibacterial chip can be ensured to slowly release NO, the concentration is gradually increased, the NO release rate is 0.21ug/min, and the NO release concentration can reach 0.25ppm at most. After the blue lamp irradiates the NO generation chip within the wavelength range of 460-470 nm, the NO release rate is 0.20ug/min, and the maximum NO release concentration can reach 0.23 ppm.
Preferably, a power supply electrically connected with the light source is further arranged inside the casing, and the power supply is used for supplying power to the light source.
Preferably, the light source is connected to the power supply through a constant current source chip, the constant current source chip is used for controlling the current flowing through the power supply, and the illumination intensity emitted by the light source is changed by adjusting the current.
The invention adopts a special constant current source chip to control the current of the light source, can obtain stable driving current and ensure the stable release of NO; the invention adjusts the input current of the light source through the constant current source chip, and further controls the illumination intensity of the light source, so as to achieve the purpose of controlling the release rate and the release concentration of NO. Specifically, on the premise of a certain wavelength range, when the current intensity is within a range of 200mA, the NO release rate reaches 2.14ug/min, and the NO release concentration reaches 2.50 ppm.
In a preferred embodiment of the present invention, the thickness of the NO generation chip is 0.185 to 0.385mm, and may be, for example, 0.185mm, 0.235mm, 0.285mm, 0.335mm or 0.385mm, but the thickness is not limited to the above-mentioned values, and other values not listed in the above-mentioned range are also applicable.
Under the same conditions (the light irradiation time, the light source wavelength, and the light irradiation intensity are constant), the thicker the functional layer thickness of the NO generation chip is, the higher the concentration of NO to be released. Thus, the following two schemes can be selected:
(1) the thickness of the chip is increased, the NO directly generates the chip, but the thickness of the effective functional layer is not increased in equal proportion;
(2) the number of chips is increased, the thickness of a single functional layer is ensured, and the NO release concentration is greatly increased.
Preferably, a plurality of layers of NO generating chips are arranged in the shell.
Preferably, the NO generation chip comprises a substrate and a functional layer loaded on the surface of the substrate, wherein the functional layer comprises NO donor material.
Preferably, the NO donor material includes any one of sodium nitrosoiron hydride, S-nitroso-N-acetylpenicillamine, S-nitrosoglutathione, an azoenamelodiol series compound, or an azoenamelodiol-supported polymer, or a combination of at least two thereof.
As a preferable technical scheme of the invention, in the nasal exhalation mode, the acoustic vibration module is used for carrying out endogenous treatment on the nasal obstruction.
Preferably, the sound wave vibration module comprises a sound wave generator, a power amplifier and a loudspeaker which are electrically connected in sequence, and sound waves generated by the sound wave generator are amplified by the power amplifier and then are output by the loudspeaker to vibrate.
Preferably, the power amplifier is electrically connected to the power supply, and the power supply is used for supplying power to the power amplifier.
As a preferred technical scheme of the present invention, a controller is further disposed in the housing, the controller is electrically connected to the constant current source chip and the power amplifier, and the controller independently controls the illumination intensity of the light source and the amplification factor of the power amplifier through the constant current source chip and the power amplifier.
Preferably, the controller is further electrically connected to the sound wave generator, and the controller is configured to control a sound wave waveform and a sound wave frequency emitted by the sound wave generator.
In a second aspect, the present invention provides a method of using the nasal obstruction control device of the first aspect, the method of using comprising:
after the NO generating chip is irradiated by the light source, the NO generating chip is excited to generate NO gas, and the patient inhales the NO gas and then carries out nasal obstruction treatment from an external source; the sound waves generated by the sound wave vibration module vibrate the nose of the patient, and the nasal obstruction treatment is performed from the inner source.
As a preferable technical scheme, the using method specifically comprises a nasal expiration mode and a nasal inspiration mode.
Preferably, in the nasal expiration mode, the sound wave generator is started, sound waves are amplified and then emitted by the loudspeaker to vibrate, the controller controls the sound wave waveform, the sound wave frequency and the sound wave amplification factor generated by the sound wave generator, the patient keeps an expiration state, and the nasal obstruction is subjected to endogenous therapy under the vibration effect of the sound waves.
Preferably, in the nasal inhalation mode, the light source is started, the NO generation chip releases NO under the irradiation of the light source, the NO release concentration is controlled by adjusting the illumination time, the wavelength of the light source and the illumination intensity, the patient keeps the inhalation state and inhales NO gas, and the nasal obstruction is treated by the NO gas in an exogenous mode.
Preferably, during normal patient breathing, the nasal exhalation mode and the nasal inhalation mode alternate, alternating between endogenous and exogenous treatment of the nasal prongs.
As a preferable technical solution of the present invention, in the nasal exhalation mode, the acoustic waveform is a sine wave.
Preferably, the sound wave frequency is 108 to 148Hz, such as 108Hz, 110Hz, 115Hz, 120Hz, 125Hz, 130Hz, 135Hz, 140Hz, 145Hz or 148Hz, but not limited to the listed values, and other values not listed in the range of values are also applicable.
The generation process of the sound wave comprises the following steps:
the controller controls the sound generator to generate fundamental waves and adjusts the duty ratio, the fundamental waves are increased from 1% to 50% and then decreased to 1%, and sine waves are formed through simulation; then, after the sound wave is amplified by a power amplifier, a loudspeaker is driven to generate sound waves; preferably, the frequency of the fundamental wave is 30 Hz.
In a preferred embodiment of the present invention, the light irradiation time is 1 to 5min, for example, 1.0min, 1.5min, 2.0min, 2.5min, 3.0min, 3.5min, 4.0min, 4.5min or 5.0min in the nasal inhalation mode, but is not limited to the above-mentioned values, and other values not listed in the above-mentioned range are also applicable.
Preferably, the adjustment of the wavelength of the light sources is achieved by switching the light sources of different colors.
Preferably, the intensity of the light wave generated by the light source is controlled by the input current.
Preferably, the current is 50 to 500mA, and may be, for example, 50mA, 100mA, 150mA, 200mA, 250mA, 300mA, 350mA, 400mA, 450mA or 500mA, but is not limited to the recited values, and other values not recited within the range of values are also applicable.
Preferably, the NO gas is released at a concentration of 0.5 to 1.5ppm, for example 0.5ppm, 0.6ppm, 0.7ppm, 0.8ppm, 0.9ppm, 1.0ppm, 1.1ppm, 1.2ppm, 1.3ppm, 1.4ppm or 1.5ppm, but not limited to the recited values, and other values not recited in this range of values are equally applicable.
Compared with the prior art, the invention has the beneficial effects that:
the nasal obstruction treatment device comprehensively treats the problem of nasal obstruction by inputting NO from an external source and carrying out sound wave vibration from an internal source, can help to recover and enhance mucociliary function after NO gas enters a nasal cavity, enhances the defense capability to chronic colonized pathogens, reduces or even prevents the continuation of diseases, and carries out adaptive adjustment on the release speed of NO and the release concentration of NO by adjusting illumination time, light source wavelength and illumination intensity, so that corresponding NO gas treatment can be provided for different people of different ages, sexes and symptoms.
Drawings
Fig. 1 is a flowchart illustrating the operation of the nasal obstruction prevention device according to an embodiment of the present invention;
FIG. 2 is a graph showing NO emissions from a layer of antimicrobial chips illuminated by different light sources at 100mA current according to one embodiment of the present invention;
FIG. 3 is a graph showing the NO curve released by a Bao blue lamp irradiating a layer of antibacterial chip under different currents according to an embodiment of the present invention;
FIG. 4 is a graph showing NO curves emitted from a Bao blue lamp irradiating different numbers of antibacterial chips at a specific current according to an embodiment of the present invention;
FIG. 5 is a waveform diagram of a fundamental wave generated by an acoustic wave generator according to an embodiment of the present invention;
fig. 6 is a waveform diagram of a simulated sine wave according to an embodiment of the present invention.
Detailed Description
It is to be understood that in the description of the present invention, the terms "center", "longitudinal", "lateral", "up", "down", "front", "back", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", etc., indicate orientations or positional relationships based on those shown in the drawings, and are used only for convenience in describing the present invention and for simplicity in description, and do not indicate or imply that the device or element being referred to must have a particular orientation, be constructed and operated in a particular orientation, and thus, should not be taken as limiting the present invention. Furthermore, the terms "first", "second", etc. are used for descriptive purposes only and are not to be construed as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defined as "first," "second," etc. may explicitly or implicitly include one or more of that feature. In the description of the present invention, "a plurality" means two or more unless otherwise specified.
It should be noted that, in the description of the present invention, unless otherwise explicitly specified or limited, the terms "disposed," "connected" and "connected" are to be construed broadly, and may be, for example, fixedly connected, detachably connected, or integrally connected; can be mechanically or electrically connected; they may be connected directly or indirectly through intervening media, or they may be interconnected between two elements. The specific meaning of the above terms in the present invention can be understood by those of ordinary skill in the art through specific situations.
The technical solution of the present invention is further explained by the following embodiments.
In one embodiment, the present invention provides a nasal obstruction control device that combines endogenous and exogenous nitric oxide, the nasal obstruction control device comprising a housing having a breathing orifice that, in use, covers a patient's nose;
the NO generation module and the sound wave vibration module are arranged in the shell; the NO generation module comprises a light source and an NO generation chip, the NO generation chip is excited to generate NO gas after being irradiated by the light source, and the patient inhales the NO gas and then carries out nasal obstruction treatment from an external source; the sound waves generated by the sound wave vibration module vibrate the nose of the patient, and nasal obstruction treatment is performed from an internal source.
The nasal obstruction treatment device comprehensively treats the problem of nasal obstruction by inputting NO from an external source and carrying out sound wave vibration from an internal source, can help to recover and enhance mucociliary function after NO gas enters a nasal cavity, enhances the defense capability to chronic colonized pathogens, reduces or even prevents the continuation of diseases, and carries out adaptive adjustment on the release speed of NO and the release concentration of NO by adjusting illumination time, light source wavelength and illumination intensity, so that corresponding NO gas treatment can be provided for different people of different ages, sexes and symptoms.
Further, the nasal obstruction control device includes a nasal inhalation mode and a nasal exhalation mode.
Furthermore, a one-way inhalation valve and a one-way exhalation valve are arranged on the shell.
Further, in the nasal inhalation mode, the one-way inhalation valve is opened, and meanwhile, the one-way exhalation valve is closed, so that air in the external environment enters the shell through the one-way inhalation valve to supply oxygen to the patient.
Further, in the nasal expiration mode, the one-way inhalation valve is closed, and simultaneously the one-way exhalation valve is opened, and the gas exhaled by the patient is exhausted by the one-way exhalation valve.
Furthermore, the one-way inhalation valve and the one-way exhalation valve are positioned on the shell close to the breathing port, the one-way inhalation valve and the one-way exhalation valve are arranged oppositely, and when the one-way inhalation valve is used, the one-way inhalation valve is positioned below the one-way exhalation valve, and the one-way exhalation valve is positioned above the one-way exhalation valve.
Further, a breathing mask is arranged at the breathing hole, and when the mask is used, the nose of a patient is covered by the breathing mask.
Further, in the nasal inhalation mode, exogenous nitric oxide treatment is performed by the light source and the NO generation chip.
Further, the light source includes a blue light, a green light, and a blue light.
Furthermore, the light-emitting wavelength range of the Baolan lamp is 450-455 nm.
Furthermore, the light-emitting wavelength range of the green lamp is 570-575 nm.
Furthermore, the light-emitting wavelength range of the blue lamp is 460-470 nm.
It should be noted that the light source provided by the present invention is preferably a spherical light source, and the adoption of the spherical light source can ensure the uniform dispersion of the light wave to the maximum extent, so that the effective release rate of the NO generation chip is the highest. The NO generation chip is respectively irradiated by three light sources with different light-emitting wavelengths, and the concentration and the release rate of NO which is excited and released by the NO generation chip under different wavelengths are different; specifically, the method comprises the following steps: after the Bao blue lamp irradiates the NO generation chip within the wavelength range of 450-455, the NO can be rapidly released within a short time to reach higher NO concentration, the NO release rate is 0.84ug/min, and the NO release concentration can reach 0.98ppm at most. After the green lamp irradiates the NO generation chip within the wavelength range of 570-575 nm, the antibacterial chip can be ensured to slowly release NO, the concentration is gradually increased, the NO release rate is 0.21ug/min, and the NO release concentration can reach 0.25ppm at most. After the blue lamp irradiates the NO generation chip within the wavelength range of 460-470 nm, the NO release rate is 0.20ug/min, and the maximum NO release concentration can reach 0.23 ppm.
In order to study the influence of light sources with different wavelength ranges on NO release concentration, the invention screens a Bao blue lamp, a blue lamp and a green lamp to respectively illuminate an NO generation chip (single layer) under the condition of 100mA input current, wherein each lamp source illuminates for 1min, 2min, 3min, 4min and 5min, the NO release concentration under different illumination time is detected, and test data are summarized and then a curve chart shown in figure 2 is drawn. As can be seen from FIG. 2, the release rate of NO gas is fastest when the sapphire blue lamp irradiates, the concentration of generated NO reaches the peak value within 2min, and then the NO release concentration is reduced along with the extension of the irradiation time; the blue lamp and the green lamp have similar influence on the NO release rate and the NO release concentration, and when the blue lamp and the green lamp are adopted for irradiation, the NO is slowly released, and the NO release concentration is far lower than the NO release rate when the blue lamp and the green lamp are adopted for irradiation. Different release concentrations and release rates may be used for different nasal prong types.
Furthermore, a power supply electrically connected with the light source is further arranged inside the casing, and the power supply is used for supplying power to the light source.
Furthermore, the light source is connected to the power supply through a constant current source chip, the constant current source chip is used for controlling the current flowing through the power supply, and the illumination intensity emitted by the light source is changed by adjusting the current.
The invention adopts a special constant current source chip to control the current of the light source, can obtain stable driving current and ensure the stable release of NO; the invention adjusts the input current of the light source through the constant current source chip, and further controls the illumination intensity of the light source, so as to achieve the purpose of controlling the release rate and the release concentration of NO. Specifically, on the premise of a certain wavelength range, when the current intensity is within a range of 200mA, the NO release rate reaches 2.14ug/min, and the NO release concentration reaches 2.50 ppm.
In order to study the influence of the current magnitude on the NO release concentration, the invention adopts a Bao blue lamp as a light source, adjusts the magnitude of input current (100mA and 200mA), irradiates the same NO generation chip (single layer) and detects the NO release concentration, arranges 3 samples for each input current, and totally arranges 6 samples, which are respectively: the detection conditions of the sample A, the sample B and the sample C (input current is 100mA), and the sample D, the sample E and the sample F (input current is 200mA) are summarized in Table 1, the irradiation time of 6 samples is 1min, 1.5min, 2min, 2.5min and 3min, and the detected NO release concentrations are summarized and plotted in a graph as shown in FIG. 3. As can be seen from FIG. 3, the NO release concentration at 200mA current was high but the duration was short, reaching a peak concentration within 2min, but then rapidly decreasing within 1 min; while the NO release concentration under the current of 100mA is not high, the concentration peak value is far lower than that under the current of 200mA, but the NO concentration decays slowly.
Furthermore, the thickness of the NO generation chip is 0.185-0.385 mm.
Under the same conditions (the light irradiation time, the light source wavelength, and the light irradiation intensity are constant), the thicker the functional layer thickness of the NO generation chip is, the higher the concentration of NO to be released. Thus, the following two schemes can be selected:
(1) the thickness of the chip is increased, the NO directly generates the chip, but the thickness of the effective functional layer is not increased in equal proportion;
(2) the number of chips is increased, the thickness of a single functional layer is ensured, and the NO release concentration is greatly increased.
In order to study the influence of the number of layers on the NO release concentration, the invention adopts a Bao blue lamp as a light source, the input current uniformly adopts 200mA, the number of layers (single layer and double layer) of NO generating chips is adjusted, the NO release concentration is detected, 3 samples are arranged on the NO generating chips with each number of layers, and 6 samples are respectively: the detection conditions of the sample G, the sample H and the sample I (single-layer NO generating chip), and the sample J, the sample K and the sample L (double-layer NO generating chip) are summarized in table 1, the irradiation time of 6 samples is 1min, 1.5min, 2min, 2.5min and 3min, and the detected NO release concentrations are summarized and plotted in a graph as shown in fig. 4. As can be seen from FIG. 4, the NO release concentration of the double-layer NO generation chip is higher, and the concentration peak value is reached within 2 min; the single layer NO generating chip has a low NO emission concentration.
TABLE 1
Furthermore, a plurality of layers of NO generating chips are arranged in the shell.
Further, the NO generation chip comprises a substrate and a functional layer loaded on the surface of the substrate, wherein the functional layer comprises NO donor materials.
Further, the NO donor material includes any one of sodium nitrosoiron hydride, S-nitroso-N-acetylpenicillamine, S-nitrosoglutathione, an azoene diol series compound, or an azoene diol-supported polymer, or a combination of at least two thereof.
Further, in the nasal exhalation mode, the nasal plug is subjected to endogenous treatment through the sound wave vibration module.
Furthermore, the sound wave vibration module comprises a sound wave generator, a power amplifier and a loudspeaker which are electrically connected in sequence, and sound waves generated by the sound wave generator are output by the loudspeaker after the power of the sound waves is amplified by the power amplifier.
Further, the power amplifier is electrically connected to the power supply, and the power supply is used for supplying power to the power amplifier.
Furthermore, a controller is arranged in the casing, the controller is electrically connected with the constant current source chip and the power amplifier respectively, and the controller controls the illumination intensity of the light source and the amplification factor of the power amplifier respectively and independently through the constant current source chip and the power amplifier.
Furthermore, the controller is also electrically connected to the sound wave generator, and the controller is used for controlling the sound wave waveform and the sound wave frequency emitted by the sound wave generator.
In another embodiment, the present invention provides a method of using the nasal obstruction control device provided in the above embodiment, the method of using comprising:
after the NO generating chip is irradiated by the light source, the NO generating chip is excited to generate NO gas, and the patient inhales the NO gas and then carries out nasal obstruction treatment from an external source; the sound waves generated by the sound wave vibration module vibrate the nose of the patient, and the nasal obstruction treatment is performed from the inner source.
Further, as shown in fig. 1, the using method specifically comprises a nasal exhalation mode and a nasal inhalation mode.
Further, in a nasal expiration mode, the sound wave generator is started, sound waves are amplified and then sent out by the loudspeaker to vibrate, the controller controls the sound wave waveform, the sound wave frequency and the sound wave amplification factor generated by the sound wave generator, the patient keeps an expiration state, and the nasal plug is subjected to endogenous therapy under the vibration effect of the sound waves.
Further, in the nasal inhalation mode, the light source is started, the NO generation chip releases NO under the irradiation of the light source, the NO release concentration is controlled by adjusting the illumination time, the wavelength of the light source and the illumination intensity, the patient keeps the inhalation state and inhales NO gas, and the nasal obstruction is treated by the NO gas in an exogenous mode.
Further, during the normal breathing process of the patient, the nasal expiration mode and the nasal inspiration mode are alternately carried out, and endogenous therapy and exogenous therapy are alternately carried out on the nasal obstruction.
Further, in the nasal exhalation mode, the acoustic waveform is a sine wave.
Further, the frequency of the sound wave is 108-148 Hz.
The generation process of the sound wave comprises the following steps:
the controller controls the sound wave generator to generate fundamental waves (as shown in FIG. 5, the frequency of the fundamental waves is 30Hz) and adjusts the duty ratio, the fundamental waves are increased from 1% to 50% and then decreased from 1% to 1%, and sine waves are simulated (as shown in FIG. 6); then amplified by a power amplifier and drives a loudspeaker to generate sound waves.
Further, in a nasal inhalation mode, the illumination time is 1-5 min.
Further, the adjustment of the wavelength of the light source is realized by switching the light sources of different colors.
Further, the intensity of the light wave generated by the light source is controlled by the input current.
Further, the current is 50-500 mA.
Further, the release concentration of the NO gas is 0.5-1.5 ppm.
The applicant declares that the above description is only a specific embodiment of the present invention, but the scope of the present invention is not limited thereto, and it should be understood by those skilled in the art that any changes or substitutions that can be easily conceived by those skilled in the art within the technical scope of the present invention are within the scope and disclosure of the present invention.
Claims (10)
1. A nasal obstruction control device that combines endogenous and exogenous nitric oxide, wherein the nasal obstruction control device comprises a housing having a breathing orifice that, in use, covers a patient's nose;
the NO generation module and the sound wave vibration module are arranged in the shell; the NO generation module comprises a light source and an NO generation chip, the NO generation chip is excited to generate NO gas after being irradiated by the light source, and the patient inhales the NO gas and then carries out nasal obstruction treatment from an external source; the sound waves generated by the sound wave vibration module vibrate the nose of the patient, and nasal obstruction treatment is performed from an internal source.
2. The nasal obstruction control device of claim 1, wherein the nasal obstruction control device comprises a nasal inhalation mode and a nasal exhalation mode;
preferably, a one-way inhalation valve and a one-way exhalation valve are arranged on the casing;
preferably, in the nasal inhalation mode, the one-way inhalation valve is opened, and simultaneously the one-way exhalation valve is closed, so that air in the external environment enters the shell through the one-way inhalation valve to supply oxygen to the patient;
preferably, in the nasal expiration mode, the one-way inhalation valve is closed, the one-way exhalation valve is opened, and the gas exhaled by the patient is exhausted by the one-way exhalation valve;
preferably, the breathing hole is provided with a breathing mask, and when the mask is used, the nose of a patient is covered by the breathing mask.
3. The nasal obstruction control device according to claim 2, wherein in the nasal inhalation mode, exogenous nitric oxide therapy is performed by the light source and the NO generating chip;
preferably, the light source comprises a blue light, a green light and a blue light;
preferably, the emission wavelength range of the Baolan lamp is 450-455 nm;
preferably, the light-emitting wavelength range of the green lamp is 570-575 nm;
preferably, the light-emitting wavelength range of the blue lamp is 460-470 nm;
preferably, a power supply electrically connected with the light source is further arranged inside the casing, and the power supply is used for supplying power to the light source;
preferably, the light source is connected to the power supply through a constant current source chip, the constant current source chip is used for controlling the current flowing through the power supply, and the illumination intensity emitted by the light source is changed by adjusting the current.
4. The nasal obstruction control device according to claim 3, wherein the NO generating chip has a thickness of 0.185 to 0.385 mm;
preferably, a plurality of layers of NO generating chips are arranged in the shell;
preferably, the NO generation chip comprises a substrate and a functional layer loaded on the surface of the substrate, wherein the functional layer comprises NO donor materials;
preferably, the NO donor material includes any one of sodium nitrosoiron hydride, S-nitroso-N-acetylpenicillamine, S-nitrosoglutathione, an azoenamelodiol series compound, or an azoenamelodiol-supported polymer, or a combination of at least two thereof.
5. The nasal obstruction control device of claim 3, wherein in the nasal exhalation mode, the nasal obstruction is endogenously treated by the sonic vibration module;
preferably, the sound wave vibration module comprises a sound wave generator, a power amplifier and a loudspeaker which are electrically connected in sequence, and sound waves generated by the sound wave generator are amplified by the power amplifier and then are output by the loudspeaker;
preferably, the power amplifier is electrically connected to the power supply, and the power supply is used for supplying power to the power amplifier.
6. The device according to claim 3, wherein a controller is further arranged in the housing, the controller is electrically connected to the constant current source chip and the power amplifier, and the controller controls the illumination intensity of the light source and the amplification factor of the power amplifier independently through the constant current source chip and the power amplifier;
preferably, the controller is further electrically connected to the sound wave generator, and the controller is configured to control a sound wave waveform and a sound wave frequency emitted by the sound wave generator.
7. A method of using the nasal obstruction control device of any one of claims 1-6, wherein the method of use comprises:
after the NO generating chip is irradiated by the light source, the NO generating chip is excited to generate NO gas, and the patient inhales the NO gas and then carries out nasal obstruction treatment from an external source; the sound waves generated by the sound wave vibration module vibrate the nose of the patient, and the nasal obstruction treatment is performed from the inner source.
8. Use according to claim 7, in particular comprising a nasal exhalation mode and a nasal inhalation mode;
preferably, in the nasal expiration mode, the sound wave generator is started, sound waves are amplified and then sent out by the loudspeaker to vibrate, the controller controls the sound wave waveform, the sound wave frequency and the sound wave amplification factor generated by the sound wave generator, the patient keeps an expiration state, and the nasal plug is subjected to endogenous therapy under the vibration effect of the sound waves;
preferably, in the nasal inhalation mode, the light source is started, the NO generation chip releases NO under the irradiation of the light source, the NO release concentration is controlled by adjusting the illumination time, the wavelength of the light source and the illumination intensity, the patient keeps the inhalation state and inhales NO gas, and the nasal obstruction is treated by the NO gas;
preferably, during normal patient breathing, the nasal exhalation mode and the nasal inhalation mode alternate, alternating between endogenous and exogenous treatment of the nasal prongs.
9. Use according to claim 8, wherein in nasal exhalation mode, the sonic waveform is a sine wave;
preferably, the frequency of the sound wave is 108-148 Hz.
10. The use method according to claim 8, wherein in the nasal inhalation mode, the illumination time is 1-5 min;
preferably, the adjustment of the wavelength of the light source is achieved by switching light sources of different colors;
preferably, the intensity of the light wave generated by the light source is controlled by the input current;
preferably, the current is 50-500 mA;
preferably, the release concentration of the NO gas is 0.5-1.5 ppm.
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| US5839433A (en) * | 1993-10-12 | 1998-11-24 | Higenbottam; Timothy William | Nitric oxide treatment |
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| CN112203627A (en) * | 2019-05-07 | 2021-01-08 | 健康蜂鸣有限公司 | Therapeutic device for treating conditions associated with sinuses, nasal cavity, ears, nose and throat |
| US20210178106A1 (en) * | 2019-08-23 | 2021-06-17 | NOTA Laboratories, LLC | Nitric oxide generating systems for inhalation |
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| US5839433A (en) * | 1993-10-12 | 1998-11-24 | Higenbottam; Timothy William | Nitric oxide treatment |
| CN101198368A (en) * | 2005-04-14 | 2008-06-11 | 普尔莫诺克斯科技公司 | Nitric oxide decontamination of the upper respiratory tract |
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