CN114306923A - Shaftless magnetic suspension ventricle auxiliary device - Google Patents
Shaftless magnetic suspension ventricle auxiliary device Download PDFInfo
- Publication number
- CN114306923A CN114306923A CN202111419543.3A CN202111419543A CN114306923A CN 114306923 A CN114306923 A CN 114306923A CN 202111419543 A CN202111419543 A CN 202111419543A CN 114306923 A CN114306923 A CN 114306923A
- Authority
- CN
- China
- Prior art keywords
- mounting groove
- stator casing
- rotor
- assist device
- ventricular assist
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000725 suspension Substances 0.000 title claims abstract description 20
- 229910000976 Electrical steel Inorganic materials 0.000 claims abstract description 14
- 238000004804 winding Methods 0.000 claims abstract description 14
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical group [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims abstract description 13
- 230000002861 ventricular Effects 0.000 claims description 18
- 238000005339 levitation Methods 0.000 claims 5
- 208000007536 Thrombosis Diseases 0.000 abstract description 8
- 206010018910 Haemolysis Diseases 0.000 abstract description 3
- 238000005299 abrasion Methods 0.000 abstract description 3
- 238000010438 heat treatment Methods 0.000 abstract description 3
- 230000008588 hemolysis Effects 0.000 abstract description 3
- 210000004369 blood Anatomy 0.000 description 15
- 239000008280 blood Substances 0.000 description 15
- 239000002473 artificial blood Substances 0.000 description 7
- 210000004204 blood vessel Anatomy 0.000 description 7
- 210000000709 aorta Anatomy 0.000 description 6
- BGPVFRJUHWVFKM-UHFFFAOYSA-N N1=C2C=CC=CC2=[N+]([O-])C1(CC1)CCC21N=C1C=CC=CC1=[N+]2[O-] Chemical compound N1=C2C=CC=CC2=[N+]([O-])C1(CC1)CCC21N=C1C=CC=CC1=[N+]2[O-] BGPVFRJUHWVFKM-UHFFFAOYSA-N 0.000 description 4
- 239000000306 component Substances 0.000 description 3
- 230000015572 biosynthetic process Effects 0.000 description 2
- 230000017531 blood circulation Effects 0.000 description 2
- 230000023555 blood coagulation Effects 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 230000006870 function Effects 0.000 description 2
- 238000010008 shearing Methods 0.000 description 2
- 230000002792 vascular Effects 0.000 description 2
- 208000005189 Embolism Diseases 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 239000012503 blood component Substances 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 230000004087 circulation Effects 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 210000003743 erythrocyte Anatomy 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 230000004217 heart function Effects 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 230000010412 perfusion Effects 0.000 description 1
- 238000005086 pumping Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 239000010979 ruby Substances 0.000 description 1
- 229910001750 ruby Inorganic materials 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
Images
Landscapes
- External Artificial Organs (AREA)
Abstract
The invention discloses a shaftless magnetic suspension ventricle auxiliary device which comprises an annular stator casing, wherein the upper port and the lower port of the stator casing are connected with pipelines; the inner side of the stator casing is provided with an inner mounting groove, the outer side of the stator casing is provided with an outer mounting groove, the inner mounting groove and the outer mounting groove correspond in position, and a mounting hole is formed between the inner mounting groove and the outer mounting groove; an annular rotor permanent magnet is arranged in the inner mounting groove, a rotor iron core ring is arranged on the inner ring of the rotor permanent magnet, and a plurality of blades are arranged on the inner side of the rotor iron core ring; an annular mounting piece is mounted in the outer mounting groove, a silicon steel sheet is arranged on the inner side of the mounting piece and located in the mounting hole, and two groups of winding coils are arranged on the silicon steel sheet; the invention avoids the flow field dead zone of the mechanical bearing, has no heating and mechanical abrasion, and reduces the risks of equipment thrombosis, hemolysis and mechanical failure to the minimum.
Description
Technical Field
The invention relates to a shaftless magnetic suspension ventricular assist device, which is an auxiliary circulating device for replacing a ventricle to do work.
Background
A ventricular assist device is a mechanical assist device for the heart that provides support to the circulation when the heart function fails to meet the perfusion requirements of the system. The main component of the ventricular assist device is a mechanical pump which can replace the blood pumping function of the heart, so that the function of the failing heart can be recovered. At present, the types of ventricular assist devices mainly comprise a pulsating diaphragm pump, a mechanical or magnetic suspension bearing centrifugal pump and a mechanical bearing axial flow pump. Among them, the axial flow pump (such as heart rate 2) is the most implanted ventricular assist device at present, and its structure includes: 1. a stator containing coil windings capable of releasing a periodically rotating magnetic field; 2. the rotor is internally provided with a permanent magnet, the surface of the rotor is embedded with a blade similar to an Archimedes spiral line, the blade is vertical to the surface of the rotor, and when the rotor rotates, blood can be driven to flow towards the long axis direction of the pump; 3. and the ruby bearing is used as a mechanical support for the rotation of the rotor. During the use of the conventional mechanical bearing axial flow ventricular assist device, the thrombus generated at the bearing causes the embolism of important organs of a patient and mechanical failure, which are main problems limiting the safety of equipment. The conventional improvement of the axial flow ventricular assist device is to optimize a flow field by improving the shape design of blades or change the material of a bearing to increase the blood compatibility, but the fundamental problem cannot be solved.
The magnetic suspension centrifugal pump is a ventricular assist mode with the best blood compatibility at present, a pump inlet is vertical to a rotor plane, a pump outlet is on the same horizontal plane with the rotor plane, the inlet and the outlet are vertical to each other in spatial position, blades are generally embedded on the rotor plane, the blood flow direction is changed by 90 degrees after blood enters a pump cavity, and then the blood is pumped out through the outlet. Therefore, the blood components are repeatedly acted by the shearing force of the blades after entering the pump cavity, and researches show that the blood coagulation components in the blood are damaged by the repeated shearing force action, and complications such as digestive tract outlet and the like can be caused for a long time. In addition, the rotor is in the shape of a flat cylinder, only the circular upper surface is embedded with the impeller, other surfaces are smooth planes, a dead zone which does not flow is formed between the rotor and the pump shell, and once the dead zone is formed, thrombus is formed.
For example, the ventricular assist pump disclosed in patent document No. CN210904322U, which has no hub and adopts a two-stage front and rear guide vane structure, reduces the flow dead zone around the guide vanes by improving the guide vanes, thereby reducing the probability of thrombus formation around and reducing wear, but the bearing still has a problem that thrombus formation cannot be fundamentally stopped.
As disclosed in patent publication No. CN107281567A, this auxiliary pump also adopts a mechanical bearing design and inserts the plate on the central shaft of the rotor, but still cannot completely avoid dead space at the bearing, and there is a great risk of thrombosis.
Disclosure of Invention
The invention aims to solve the technical problem of providing a shaftless magnetic suspension ventricle auxiliary device, which avoids the flow field dead zone of the conventional mechanical bearing and the magnetic suspension centrifugal pump.
In order to solve the technical problem, the shaftless magnetic suspension ventricle auxiliary device comprises an annular stator casing, wherein the upper port and the lower port of the stator casing are connected with pipelines such as artificial blood vessels. The inner side of the stator casing is provided with an inner mounting groove, the outer side of the stator casing is provided with an outer mounting groove, the inner mounting groove and the outer mounting groove correspond in position, and a mounting hole is formed between the inner mounting groove and the outer mounting groove; an annular rotor permanent magnet is arranged in the inner mounting groove, a rotor iron core ring is arranged on the inner ring of the rotor permanent magnet, and a plurality of blades are arranged on the inner side of the rotor iron core ring; install the annular installed part in the outer mounting groove, the installed part inboard is provided with the silicon steel sheet, the silicon steel sheet is located the mounting hole, be provided with two sets of winding coils on the silicon steel sheet.
The shaftless magnetic suspension ventricular assist device consists of a magnetic suspension shaftless pump and an artificial blood vessel, wherein the artificial blood vessel is connected with the shaftless pump in advance, and when the shaftless magnetic suspension ventricular assist device is used, the artificial blood vessel can be connected to an aorta from the apex of the heart or directly replaces a section of ascending aorta. Two sets of windings which are respectively and independently controlled are wound on the silicon steel sheet of the stator, one set of windings controls the suspension of the rotor, the other set of windings controls the rotation of the rotor, and the two sets of windings can realize mutual noninterference and cooperative work through suspension force decoupling.
The interior mounting groove is the arc, rotor permanent magnet outer lane is the arc that corresponds with interior mounting groove. Further, stator casing inboard is provided with arc boss, lower arc boss, it is located interior mounting groove top edge to go up the arc boss, arc boss is located interior mounting groove bottom edge down, go up arc boss surface, interior mounting groove face, arc boss surface constitution continuous crooked curved surface down.
Preferably, the outer surface of the stator casing is cambered.
Specifically, the number of the mounting holes is six. The stator casing is hollow.
The rotor of the invention consists of a rotor permanent magnet, a rotor iron core ring and an integrated blade, wherein the blade is embedded at the inner side of the rotor iron core ring. Blood is mainly driven through the cavity channel in the rotor iron core ring, and due to the pressure difference between the inside of the rotor iron core ring and the bearing gap, a part of blood can rapidly pass through the gap of the stator and the rotor to form a channel which continuously washes the bearing gap, so that red blood cells and blood coagulation components are prevented from being deposited in the bearing gap. In addition, because the bearing clearance is extremely small, the flow speed is high, and no backflow is formed, the whole flow field is very smooth, the contact time of blood in the stator shell is extremely short, and no dead zone or backflow exists. The application of the magnetic suspension technology avoids the flow field dead zone of the mechanical bearing, no heating and no mechanical abrasion are generated, and the risks of equipment thrombosis, hemolysis and mechanical failure are reduced to the minimum. With blade, rotor, blood runner integrated design, do not have the appearance of any "axle" in the whole pump, simple structure, the contact time of blood and blade is extremely short, has reduced the risk of blood destruction, and rotor and stator shell design are curved surface streamline, have avoided the blind spot in the pump equally too.
Drawings
The present invention will be described in further detail with reference to the accompanying drawings and specific embodiments.
FIG. 1 is an external view of the present invention.
Fig. 2 is an exploded view of the present invention.
Fig. 3 is a schematic view of a stator casing and the interior thereof.
Fig. 4 is a schematic view of a stator casing.
Fig. 5 is a schematic view of a rotor permanent magnet.
Fig. 6 is a schematic view of a rotor core ring.
Fig. 7 is a schematic view of the ring-shaped mounting member and the silicon steel sheet.
Fig. 8 is a schematic view of an artificial blood vessel connecting from the apex of the heart to the aorta.
Fig. 9 is a schematic view of an artificial blood vessel replacing a section of ascending aorta.
Detailed Description
As shown in fig. 1 and 2, the shaftless magnetic suspension ventricular assist device comprises an annular stator casing 1, the stator casing 1 is hollow, the outer surface of the stator casing 1 is arc-shaped, and the upper port and the lower port of the stator casing 1 are connected with an artificial blood vessel 2. The vascular prosthesis 2 is pre-connected to a shaftless pump (i.e. the stator housing 1) and in use, the vascular prosthesis 2 may be connected from the apex of the heart to the aorta (as shown in figure 8) or may directly replace a section of the ascending aorta (as shown in figure 9).
As shown in fig. 2, 3 and 4, the inner side of the stator casing 1 is provided with an inner mounting groove 9, the inner mounting groove 9 is arc-shaped, an annular rotor permanent magnet 5 (as shown in fig. 5) is mounted in the inner mounting groove 9, and the outer ring of the rotor permanent magnet 5 is arc-shaped corresponding to the inner mounting groove 9. A rotor iron core ring 6 (shown in fig. 6) is installed on the inner ring of the rotor permanent magnet 5, and a plurality of blades 7 are installed on the inner side of the rotor iron core ring 6. For avoiding the interior dead zone of pump, stator casing 1 inboard is provided with arc boss 12, lower arc boss 13, it is located interior mounting groove 9 top edge to go up arc boss 12, arc boss 13 is located interior mounting groove 9 bottom edge down, it constitutes continuous curved surface to go up arc boss 12 surface, interior mounting groove 9 trough surface, lower arc boss 13 surface, and the curved surface is streamlined promptly.
As shown in fig. 4, the outer side of the stator casing 1 has an outer mounting groove 10, the annular mounting member 3 is mounted in the outer mounting groove 10, as shown in fig. 7, six groups of silicon steel sheets 4 are arranged on the inner side of the mounting member 3, and two groups of winding coils 8 are arranged on the silicon steel sheets 4. Interior mounting groove 9, outer mounting groove 10 position correspond, interior mounting groove 9, have mounting hole 11 between the outer mounting groove 10, if mounting hole 11 is six, silicon steel sheet 4 is located mounting hole 11. Two sets of windings which are respectively and independently controlled are wound on a silicon steel sheet 4 of the stator, one set of windings controls the suspension of the rotor (namely the rotor permanent magnet 5, the rotor iron core ring 6 and the blades 7), the other set of windings controls the rotation of the rotor, and the two sets of windings can realize mutual noninterference and cooperative work through the decoupling of suspension force. The control of the energization of the windings belongs to the prior art and is not described in detail in the present invention.
Blood is mainly driven through a cavity channel inside the rotor core ring 6, a small part of blood flows through the gap of the stator and the rotor, the whole flow field is a complete flow field, and the contact time of the blood in the stator shell 1 is extremely short. The application of the magnetic suspension technology avoids the flow field dead zone of the mechanical bearing, no heating and no mechanical abrasion are generated, and the risks of equipment thrombosis, hemolysis and mechanical failure are reduced to the minimum.
The above embodiments do not limit the present invention in any way, and all technical solutions obtained by means of equivalent substitution or equivalent transformation fall within the protection scope of the present invention.
Claims (6)
1. The shaftless magnetic suspension ventricular assist device is characterized by comprising an annular stator casing, wherein the upper port and the lower port of the stator casing are connected with pipelines; the inner side of the stator casing is provided with an inner mounting groove, the outer side of the stator casing is provided with an outer mounting groove, the inner mounting groove and the outer mounting groove correspond in position, and a mounting hole is formed between the inner mounting groove and the outer mounting groove; an annular rotor permanent magnet is arranged in the inner mounting groove, a rotor iron core ring is arranged on the inner ring of the rotor permanent magnet, and a plurality of blades are arranged on the inner side of the rotor iron core ring; install the annular installed part in the outer mounting groove, the installed part inboard is provided with the silicon steel sheet, the silicon steel sheet is located the mounting hole, be provided with two sets of winding coils on the silicon steel sheet.
2. A shaftless magnetic levitation ventricular assist device as claimed in claim 1, wherein: the interior mounting groove is the arc, rotor permanent magnet outer lane is the arc that corresponds with interior mounting groove.
3. A shaftless magnetic levitation ventricular assist device as claimed in claim 2, wherein: the stator casing inboard is provided with arc boss, lower arc boss, it is located interior mounting groove top edge to go up the arc boss, arc boss is located interior mounting groove bottom edge down, go up arc boss surface, interior mounting groove face, arc boss surface constitution continuous curved surface down.
4. A shaftless magnetic levitation ventricular assist device as claimed in claim 1, wherein: the outer surface of the stator casing is cambered.
5. A shaftless magnetic levitation ventricular assist device as claimed in claim 1, wherein: the mounting hole is six.
6. A shaftless magnetic levitation ventricular assist device as claimed in claim 1, wherein: the stator casing is hollow.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN202111419543.3A CN114306923A (en) | 2021-11-26 | 2021-11-26 | Shaftless magnetic suspension ventricle auxiliary device |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN202111419543.3A CN114306923A (en) | 2021-11-26 | 2021-11-26 | Shaftless magnetic suspension ventricle auxiliary device |
Publications (1)
Publication Number | Publication Date |
---|---|
CN114306923A true CN114306923A (en) | 2022-04-12 |
Family
ID=81047548
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN202111419543.3A Pending CN114306923A (en) | 2021-11-26 | 2021-11-26 | Shaftless magnetic suspension ventricle auxiliary device |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN114306923A (en) |
Citations (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5290227A (en) * | 1992-08-06 | 1994-03-01 | Pasque Michael K | Method of implanting blood pump in ascending aorta or main pulmonary artery |
US6053705A (en) * | 1996-09-10 | 2000-04-25 | Sulzer Electronics Ag | Rotary pump and process to operate it |
US20010009645A1 (en) * | 2000-01-26 | 2001-07-26 | Hiroyuki Noda | Magnetically driven axial-flow pump |
US20080292478A1 (en) * | 2005-07-01 | 2008-11-27 | Coras Medical | Axial Flow Pump with a Spiral-Shaped Vane |
US20130209292A1 (en) * | 2005-07-01 | 2013-08-15 | Doan Baykut | Axial flow blood pump with hollow rotor |
US20150141911A1 (en) * | 2012-07-03 | 2015-05-21 | Avci Elif Oran | Pulsatile flow blood pump |
CN204501842U (en) * | 2015-03-24 | 2015-07-29 | 山东科技大学 | A kind of axial-flow type magnetic suspension driving device for slow-run |
US20150367050A1 (en) * | 2012-12-20 | 2015-12-24 | Oran Bulent | Endovascular permanent heart assist device |
CN205163763U (en) * | 2015-10-22 | 2016-04-20 | 薛恒春 | Axial compressor blood vessel pump of no bearing of rotor magnetism liquid suspension |
US20160375187A1 (en) * | 2015-06-29 | 2016-12-29 | Thoratec Corporation | Ventricular assist devices having a hollow rotor and methods of use |
US20190209752A1 (en) * | 2018-01-10 | 2019-07-11 | Tc1 Llc | Bearingless implantable blood pump |
CN110496258A (en) * | 2018-05-18 | 2019-11-26 | 江苏心佑医疗器械有限公司 | Forth generation artificial heart Permanent-magnet bearing rotary pump |
CN111372618A (en) * | 2017-09-21 | 2020-07-03 | 好心公司 | Turbine with internal buckets |
CN112963359A (en) * | 2021-04-12 | 2021-06-15 | 合肥仙湖半导体科技有限公司 | Shaftless fluid jet equipment |
CN217015079U (en) * | 2021-11-26 | 2022-07-22 | 浙江首沃医疗科技有限公司 | Shaftless magnetic suspension ventricle auxiliary device |
-
2021
- 2021-11-26 CN CN202111419543.3A patent/CN114306923A/en active Pending
Patent Citations (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5290227A (en) * | 1992-08-06 | 1994-03-01 | Pasque Michael K | Method of implanting blood pump in ascending aorta or main pulmonary artery |
US6053705A (en) * | 1996-09-10 | 2000-04-25 | Sulzer Electronics Ag | Rotary pump and process to operate it |
US20010009645A1 (en) * | 2000-01-26 | 2001-07-26 | Hiroyuki Noda | Magnetically driven axial-flow pump |
US20080292478A1 (en) * | 2005-07-01 | 2008-11-27 | Coras Medical | Axial Flow Pump with a Spiral-Shaped Vane |
US20130209292A1 (en) * | 2005-07-01 | 2013-08-15 | Doan Baykut | Axial flow blood pump with hollow rotor |
US20150141911A1 (en) * | 2012-07-03 | 2015-05-21 | Avci Elif Oran | Pulsatile flow blood pump |
US20150367050A1 (en) * | 2012-12-20 | 2015-12-24 | Oran Bulent | Endovascular permanent heart assist device |
CN204501842U (en) * | 2015-03-24 | 2015-07-29 | 山东科技大学 | A kind of axial-flow type magnetic suspension driving device for slow-run |
US20160375187A1 (en) * | 2015-06-29 | 2016-12-29 | Thoratec Corporation | Ventricular assist devices having a hollow rotor and methods of use |
CN205163763U (en) * | 2015-10-22 | 2016-04-20 | 薛恒春 | Axial compressor blood vessel pump of no bearing of rotor magnetism liquid suspension |
CN111372618A (en) * | 2017-09-21 | 2020-07-03 | 好心公司 | Turbine with internal buckets |
US20190209752A1 (en) * | 2018-01-10 | 2019-07-11 | Tc1 Llc | Bearingless implantable blood pump |
CN110496258A (en) * | 2018-05-18 | 2019-11-26 | 江苏心佑医疗器械有限公司 | Forth generation artificial heart Permanent-magnet bearing rotary pump |
CN112963359A (en) * | 2021-04-12 | 2021-06-15 | 合肥仙湖半导体科技有限公司 | Shaftless fluid jet equipment |
CN217015079U (en) * | 2021-11-26 | 2022-07-22 | 浙江首沃医疗科技有限公司 | Shaftless magnetic suspension ventricle auxiliary device |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN108175884B (en) | Ventricular assist pump | |
EP2734251B1 (en) | Cardiac pump | |
CN103877630B (en) | Axial magnetic unload-type axial-flow pump heart-assist device | |
US5211546A (en) | Axial flow blood pump with hydrodynamically suspended rotor | |
EP2145108B1 (en) | Centrifugal rotary blood pump | |
JP4889492B2 (en) | Impeller | |
US20160256619A1 (en) | Dual-Pump Continuous-Flow Total Artificial Heart | |
US20060245959A1 (en) | Multiple rotor, wide blade, axial flow pump | |
CN107469168B (en) | Single-degree-of-freedom magnetic suspension centrifugal impeller for reducing thrombus | |
CN212651227U (en) | Magnetic suspension blood pump device | |
EP3706818B1 (en) | Single inflow double suction centrifugal blood pump | |
WO2017196271A1 (en) | Internal axial flow blood pump with passive magnets and hydrodynamic radial bearing | |
CN113952610A (en) | Magnetic suspension blood pump device | |
JP2003501155A (en) | Magnetic levitation supported blood pump | |
CN217015079U (en) | Shaftless magnetic suspension ventricle auxiliary device | |
CN112312835A (en) | Blood pump for mechanical circulatory support of patients with squareness | |
CN211096485U (en) | External magnetic suspension centrifugal blood pump with central magnetic pole structure | |
CN112206409B (en) | Magnetic suspension mixed flow heart pump | |
CN112156255B (en) | Magnetic suspension centrifugal blood pump with integrated extracorporeal circulation magnetic wheel | |
CN208448253U (en) | A kind of Single Degree of Freedom Magnetic suspension centrifugal impeller for reducing thrombus and occurring | |
CN114306923A (en) | Shaftless magnetic suspension ventricle auxiliary device | |
US20230381489A1 (en) | Implantable centrifugal cardiac assist pump having permanent magnets embedded in impeller | |
WO2019079275A1 (en) | Impeller for artificial heart blood pumps | |
CN219764290U (en) | Magnetic suspension ventricular assist device | |
CN115419601A (en) | Mixed-flow axial flow centrifugal assembly and artificial heart pump |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
TA01 | Transfer of patent application right | ||
TA01 | Transfer of patent application right |
Effective date of registration: 20230515 Address after: Room 2001, 20th Floor, Building A, Mingjia Science and Technology Building, No. 99 Shengli Road, Jiangning District, Nanjing City, Jiangsu Province, 210000 (Jiangning Development Zone) Applicant after: Nanjing Hanke Mingde Medical Technology Co.,Ltd. Address before: 318000 Baita Industrial Cluster, Baita Town, Xianju County, Taizhou City, Zhejiang Province Applicant before: Zhejiang shouwo Medical Technology Co.,Ltd. |