CN114072401A - 作为irak4和btk多靶点抑制剂的噁唑类化合物 - Google Patents
作为irak4和btk多靶点抑制剂的噁唑类化合物 Download PDFInfo
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- CN114072401A CN114072401A CN202080047753.1A CN202080047753A CN114072401A CN 114072401 A CN114072401 A CN 114072401A CN 202080047753 A CN202080047753 A CN 202080047753A CN 114072401 A CN114072401 A CN 114072401A
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- alkyl
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- isomer
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- LYPGDCWPTHTUDO-UHFFFAOYSA-M sodium;methanesulfinate Chemical compound [Na+].CS([O-])=O LYPGDCWPTHTUDO-UHFFFAOYSA-M 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 238000000967 suction filtration Methods 0.000 description 1
- 125000001273 sulfonato group Chemical group [O-]S(*)(=O)=O 0.000 description 1
- 230000002459 sustained effect Effects 0.000 description 1
- 238000003419 tautomerization reaction Methods 0.000 description 1
- ISIJQEHRDSCQIU-UHFFFAOYSA-N tert-butyl 2,7-diazaspiro[4.5]decane-7-carboxylate Chemical compound C1N(C(=O)OC(C)(C)C)CCCC11CNCC1 ISIJQEHRDSCQIU-UHFFFAOYSA-N 0.000 description 1
- 125000005931 tert-butyloxycarbonyl group Chemical group [H]C([H])([H])C(OC(*)=O)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 150000003509 tertiary alcohols Chemical class 0.000 description 1
- YJBKVPRVZAQTPY-UHFFFAOYSA-J tetrachlorostannane;dihydrate Chemical compound O.O.Cl[Sn](Cl)(Cl)Cl YJBKVPRVZAQTPY-UHFFFAOYSA-J 0.000 description 1
- 125000004192 tetrahydrofuran-2-yl group Chemical group [H]C1([H])OC([H])(*)C([H])([H])C1([H])[H] 0.000 description 1
- 125000003718 tetrahydrofuranyl group Chemical group 0.000 description 1
- 125000005958 tetrahydrothienyl group Chemical group 0.000 description 1
- 125000002053 thietanyl group Chemical group 0.000 description 1
- 150000003573 thiols Chemical group 0.000 description 1
- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- ITMCEJHCFYSIIV-UHFFFAOYSA-M triflate Chemical compound [O-]S(=O)(=O)C(F)(F)F ITMCEJHCFYSIIV-UHFFFAOYSA-M 0.000 description 1
- 125000004044 trifluoroacetyl group Chemical group FC(C(=O)*)(F)F 0.000 description 1
- 229910052722 tritium Inorganic materials 0.000 description 1
- 125000002221 trityl group Chemical group [H]C1=C([H])C([H])=C([H])C([H])=C1C([*])(C1=C(C(=C(C(=C1[H])[H])[H])[H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 description 1
- 239000003981 vehicle Substances 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 238000009736 wetting Methods 0.000 description 1
- 239000012224 working solution Substances 0.000 description 1
- 229910000166 zirconium phosphate Inorganic materials 0.000 description 1
Images
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
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- Health & Medical Sciences (AREA)
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- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
一类IRAK4和BTK的多靶点抑制剂，及其在制备治疗与IRAK4和BTK相关疾病的药物中的应用，具体涉及式(II)所示化合物、其异构体或其药学上可接受的盐。
Description
PCT国内申请，说明书已公开。
Claims (15)
- PCT国内申请，权利要求书已公开。
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910619602 | 2019-07-10 | ||
| CN2019106196028 | 2019-07-10 | ||
| CN2019112408438 | 2019-12-06 | ||
| CN201911240843 | 2019-12-06 | ||
| CN2020104704697 | 2020-05-28 | ||
| CN202010470469 | 2020-05-28 | ||
| PCT/CN2020/101369 WO2021004533A1 (zh) | 2019-07-10 | 2020-07-10 | 作为irak4和btk多靶点抑制剂的噁唑类化合物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN114072401A true CN114072401A (zh) | 2022-02-18 |
| CN114072401B CN114072401B (zh) | 2023-11-21 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202080047753.1A Active CN114072401B (zh) | 2019-07-10 | 2020-07-10 | 作为irak4和btk多靶点抑制剂的噁唑类化合物 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20220267322A1 (zh) |
| EP (1) | EP3998264A4 (zh) |
| JP (1) | JP7340680B2 (zh) |
| CN (1) | CN114072401B (zh) |
| WO (1) | WO2021004533A1 (zh) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20230391776A1 (en) * | 2020-12-25 | 2023-12-07 | Medshine Discovery Inc. | Amide oxazole compound |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106458982A (zh) * | 2014-01-10 | 2017-02-22 | 奥列基因发现技术有限公司 | 作为irak4抑制剂的吲唑化合物 |
| CN106456619A (zh) * | 2014-01-13 | 2017-02-22 | 奥列基因发现技术有限公司 | 作为irak4抑制剂的二环杂环衍生物 |
| CN108026065A (zh) * | 2015-07-15 | 2018-05-11 | 奥列基因发现技术有限公司 | 作为irak-4抑制剂的吲唑及氮杂吲唑化合物 |
| WO2018178947A2 (en) * | 2017-03-31 | 2018-10-04 | Aurigene Discovery Technologies Limited | Compounds and compositions for treating hematological disorders |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2004265189B2 (en) | 2003-08-15 | 2010-03-04 | Banyu Pharmaceutical Co., Ltd. | Imidazopyridine derivatives |
| CN110835338A (zh) | 2018-08-17 | 2020-02-25 | 浙江海正药业股份有限公司 | 咪唑并吡啶类衍生物及其制备方法和其在医药上的用途 |
-
2020
- 2020-07-10 JP JP2022500996A patent/JP7340680B2/ja active Active
- 2020-07-10 US US17/625,599 patent/US20220267322A1/en active Pending
- 2020-07-10 EP EP20836225.1A patent/EP3998264A4/en active Pending
- 2020-07-10 CN CN202080047753.1A patent/CN114072401B/zh active Active
- 2020-07-10 WO PCT/CN2020/101369 patent/WO2021004533A1/zh unknown
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106458982A (zh) * | 2014-01-10 | 2017-02-22 | 奥列基因发现技术有限公司 | 作为irak4抑制剂的吲唑化合物 |
| CN106456619A (zh) * | 2014-01-13 | 2017-02-22 | 奥列基因发现技术有限公司 | 作为irak4抑制剂的二环杂环衍生物 |
| CN108026065A (zh) * | 2015-07-15 | 2018-05-11 | 奥列基因发现技术有限公司 | 作为irak-4抑制剂的吲唑及氮杂吲唑化合物 |
| WO2018178947A2 (en) * | 2017-03-31 | 2018-10-04 | Aurigene Discovery Technologies Limited | Compounds and compositions for treating hematological disorders |
Also Published As
| Publication number | Publication date |
|---|---|
| US20220267322A1 (en) | 2022-08-25 |
| EP3998264A4 (en) | 2023-07-12 |
| CN114072401B (zh) | 2023-11-21 |
| JP7340680B2 (ja) | 2023-09-07 |
| EP3998264A1 (en) | 2022-05-18 |
| WO2021004533A1 (zh) | 2021-01-14 |
| JP2022540464A (ja) | 2022-09-15 |
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