CN114052246A - An antioxidant composition containing quercetagetin and gallic acid - Google Patents
An antioxidant composition containing quercetagetin and gallic acid Download PDFInfo
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- CN114052246A CN114052246A CN202010781899.0A CN202010781899A CN114052246A CN 114052246 A CN114052246 A CN 114052246A CN 202010781899 A CN202010781899 A CN 202010781899A CN 114052246 A CN114052246 A CN 114052246A
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- Prior art keywords
- gallic acid
- composition
- antioxidant composition
- antioxidant
- quercetagetin
- Prior art date
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- LNTHITQWFMADLM-UHFFFAOYSA-N gallic acid Chemical compound OC(=O)C1=CC(O)=C(O)C(O)=C1 LNTHITQWFMADLM-UHFFFAOYSA-N 0.000 title claims abstract description 97
- ZVOLCUVKHLEPEV-UHFFFAOYSA-N quercetagetin Chemical compound C1=C(O)C(O)=CC=C1C1=C(O)C(=O)C2=C(O)C(O)=C(O)C=C2O1 ZVOLCUVKHLEPEV-UHFFFAOYSA-N 0.000 title claims abstract description 57
- 239000000203 mixture Substances 0.000 title claims abstract description 49
- 229940074391 gallic acid Drugs 0.000 title claims abstract description 47
- 235000004515 gallic acid Nutrition 0.000 title claims abstract description 47
- 239000003963 antioxidant agent Substances 0.000 title claims abstract description 36
- 230000003078 antioxidant effect Effects 0.000 title claims abstract description 33
- 235000013305 food Nutrition 0.000 claims abstract description 15
- 239000003814 drug Substances 0.000 claims abstract description 10
- 235000006708 antioxidants Nutrition 0.000 claims description 33
- REFJWTPEDVJJIY-UHFFFAOYSA-N Quercetin Chemical compound C=1C(O)=CC(O)=C(C(C=2O)=O)C=1OC=2C1=CC=C(O)C(O)=C1 REFJWTPEDVJJIY-UHFFFAOYSA-N 0.000 claims description 30
- HWTZYBCRDDUBJY-UHFFFAOYSA-N Rhynchosin Natural products C1=C(O)C(O)=CC=C1C1=C(O)C(=O)C2=CC(O)=C(O)C=C2O1 HWTZYBCRDDUBJY-UHFFFAOYSA-N 0.000 claims description 15
- MWDZOUNAPSSOEL-UHFFFAOYSA-N kaempferol Natural products OC1=C(C(=O)c2cc(O)cc(O)c2O1)c3ccc(O)cc3 MWDZOUNAPSSOEL-UHFFFAOYSA-N 0.000 claims description 15
- 238000000034 method Methods 0.000 claims description 15
- 229960001285 quercetin Drugs 0.000 claims description 15
- 235000005875 quercetin Nutrition 0.000 claims description 15
- 238000007254 oxidation reaction Methods 0.000 claims description 12
- 230000008569 process Effects 0.000 claims description 12
- 239000000654 additive Substances 0.000 claims description 11
- 230000000996 additive effect Effects 0.000 claims description 10
- 230000003647 oxidation Effects 0.000 claims description 10
- 238000002360 preparation method Methods 0.000 claims description 8
- 229940088594 vitamin Drugs 0.000 claims description 8
- 229930003231 vitamin Natural products 0.000 claims description 8
- 239000011782 vitamin Substances 0.000 claims description 8
- 235000013343 vitamin Nutrition 0.000 claims description 8
- 235000021466 carotenoid Nutrition 0.000 claims description 7
- 150000001747 carotenoids Chemical class 0.000 claims description 7
- 239000002537 cosmetic Substances 0.000 claims description 6
- 235000005881 Calendula officinalis Nutrition 0.000 claims description 4
- 229930182470 glycoside Natural products 0.000 claims description 3
- 239000003995 emulsifying agent Substances 0.000 claims description 2
- 239000007788 liquid Substances 0.000 claims description 2
- 229910021645 metal ion Inorganic materials 0.000 claims description 2
- 239000003094 microcapsule Substances 0.000 claims description 2
- 239000000843 powder Substances 0.000 claims description 2
- 238000009472 formulation Methods 0.000 claims 4
- 230000000979 retarding effect Effects 0.000 claims 3
- 241000736851 Tagetes Species 0.000 claims 2
- 239000002417 nutraceutical Substances 0.000 claims 2
- 235000021436 nutraceutical agent Nutrition 0.000 claims 2
- 239000003921 oil Substances 0.000 claims 2
- 235000019198 oils Nutrition 0.000 claims 2
- 239000000969 carrier Substances 0.000 claims 1
- 150000002148 esters Chemical class 0.000 claims 1
- 239000003925 fat Substances 0.000 claims 1
- 235000019197 fats Nutrition 0.000 claims 1
- 150000002338 glycosides Chemical class 0.000 claims 1
- 239000004615 ingredient Substances 0.000 claims 1
- 239000003352 sequestering agent Substances 0.000 claims 1
- 229940079593 drug Drugs 0.000 abstract description 5
- 230000002195 synergetic effect Effects 0.000 abstract description 3
- LUJAXSNNYBCFEE-UHFFFAOYSA-N Quercetin 3,7-dimethyl ether Natural products C=1C(OC)=CC(O)=C(C(C=2OC)=O)C=1OC=2C1=CC=C(O)C(O)=C1 LUJAXSNNYBCFEE-UHFFFAOYSA-N 0.000 abstract 1
- PUTDIROJWHRSJW-UHFFFAOYSA-N Quercitrin Natural products CC1OC(Oc2cc(cc(O)c2O)C3=CC(=O)c4c(O)cc(O)cc4O3)C(O)C(O)C1O PUTDIROJWHRSJW-UHFFFAOYSA-N 0.000 abstract 1
- OXGUCUVFOIWWQJ-XIMSSLRFSA-N acanthophorin B Natural products O[C@H]1[C@H](O)[C@H](O)[C@H](C)O[C@H]1OC1=C(C=2C=C(O)C(O)=CC=2)OC2=CC(O)=CC(O)=C2C1=O OXGUCUVFOIWWQJ-XIMSSLRFSA-N 0.000 abstract 1
- OEKUVLQNKPXSOY-UHFFFAOYSA-N quercetin 3-O-beta-D-glucopyranosyl(1->3)-alpha-L-rhamnopyranosyl(1->6)-beta-d-galactopyranoside Natural products OC1C(O)C(C(O)C)OC1OC1=C(C=2C=C(O)C(O)=CC=2)OC2=CC(O)=CC(O)=C2C1=O OEKUVLQNKPXSOY-UHFFFAOYSA-N 0.000 abstract 1
- QPHXPNUXTNHJOF-UHFFFAOYSA-N quercetin-7-O-beta-L-rhamnopyranoside Natural products OC1C(O)C(O)C(C)OC1OC1=CC(O)=C2C(=O)C(O)=C(C=3C=C(O)C(O)=CC=3)OC2=C1 QPHXPNUXTNHJOF-UHFFFAOYSA-N 0.000 abstract 1
- OXGUCUVFOIWWQJ-HQBVPOQASA-N quercitrin Chemical compound O[C@@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@H]1OC1=C(C=2C=C(O)C(O)=CC=2)OC2=CC(O)=CC(O)=C2C1=O OXGUCUVFOIWWQJ-HQBVPOQASA-N 0.000 abstract 1
- 230000000052 comparative effect Effects 0.000 description 7
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 6
- 230000036541 health Effects 0.000 description 6
- 239000002994 raw material Substances 0.000 description 6
- BGNXCDMCOKJUMV-UHFFFAOYSA-N Tert-Butylhydroquinone Chemical compound CC(C)(C)C1=CC(O)=CC=C1O BGNXCDMCOKJUMV-UHFFFAOYSA-N 0.000 description 5
- 235000016709 nutrition Nutrition 0.000 description 5
- SPSPIUSUWPLVKD-UHFFFAOYSA-N 2,3-dibutyl-6-methylphenol Chemical compound CCCCC1=CC=C(C)C(O)=C1CCCC SPSPIUSUWPLVKD-UHFFFAOYSA-N 0.000 description 4
- 235000010354 butylated hydroxytoluene Nutrition 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 239000004519 grease Substances 0.000 description 4
- 150000002978 peroxides Chemical class 0.000 description 4
- -1 polyphenol compound Chemical class 0.000 description 4
- 241001465754 Metazoa Species 0.000 description 3
- CZBZUDVBLSSABA-UHFFFAOYSA-N butylated hydroxyanisole Chemical compound COC1=CC=C(O)C(C(C)(C)C)=C1.COC1=CC=C(O)C=C1C(C)(C)C CZBZUDVBLSSABA-UHFFFAOYSA-N 0.000 description 3
- 235000012239 silicon dioxide Nutrition 0.000 description 3
- 239000000377 silicon dioxide Substances 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 239000004250 tert-Butylhydroquinone Substances 0.000 description 3
- 235000019281 tert-butylhydroquinone Nutrition 0.000 description 3
- 206010028980 Neoplasm Diseases 0.000 description 2
- 235000019764 Soybean Meal Nutrition 0.000 description 2
- 240000000785 Tagetes erecta Species 0.000 description 2
- 239000004480 active ingredient Substances 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 230000003111 delayed effect Effects 0.000 description 2
- 238000001514 detection method Methods 0.000 description 2
- 238000011156 evaluation Methods 0.000 description 2
- 235000013824 polyphenols Nutrition 0.000 description 2
- 239000004455 soybean meal Substances 0.000 description 2
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 description 1
- AZJQQNWSSLCLJN-UHFFFAOYSA-N 2-ethoxyquinoline Chemical compound C1=CC=CC2=NC(OCC)=CC=C21 AZJQQNWSSLCLJN-UHFFFAOYSA-N 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- GAMYVSCDDLXAQW-AOIWZFSPSA-N Thermopsosid Natural products O(C)c1c(O)ccc(C=2Oc3c(c(O)cc(O[C@H]4[C@H](O)[C@@H](O)[C@H](O)[C@H](CO)O4)c3)C(=O)C=2)c1 GAMYVSCDDLXAQW-AOIWZFSPSA-N 0.000 description 1
- FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 description 1
- 230000003266 anti-allergic effect Effects 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 230000003064 anti-oxidating effect Effects 0.000 description 1
- 230000000259 anti-tumor effect Effects 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 239000002738 chelating agent Substances 0.000 description 1
- 230000006866 deterioration Effects 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 229930003944 flavone Natural products 0.000 description 1
- 150000002212 flavone derivatives Chemical class 0.000 description 1
- 235000011949 flavones Nutrition 0.000 description 1
- 230000012010 growth Effects 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- BAUYGSIQEAFULO-UHFFFAOYSA-L iron(2+) sulfate (anhydrous) Chemical compound [Fe+2].[O-]S([O-])(=O)=O BAUYGSIQEAFULO-UHFFFAOYSA-L 0.000 description 1
- 229910000359 iron(II) sulfate Inorganic materials 0.000 description 1
- SQQMAOCOWKFBNP-UHFFFAOYSA-L manganese(II) sulfate Chemical compound [Mn+2].[O-]S([O-])(=O)=O SQQMAOCOWKFBNP-UHFFFAOYSA-L 0.000 description 1
- 229910000357 manganese(II) sulfate Inorganic materials 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 229930014626 natural product Natural products 0.000 description 1
- 230000001590 oxidative effect Effects 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 230000035790 physiological processes and functions Effects 0.000 description 1
- 150000008442 polyphenolic compounds Chemical class 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000002000 scavenging effect Effects 0.000 description 1
- 235000012424 soybean oil Nutrition 0.000 description 1
- 239000003549 soybean oil Substances 0.000 description 1
- 238000012430 stability testing Methods 0.000 description 1
- 230000009044 synergistic interaction Effects 0.000 description 1
- 235000019155 vitamin A Nutrition 0.000 description 1
- 239000011719 vitamin A Substances 0.000 description 1
- 229940045997 vitamin a Drugs 0.000 description 1
- VHBFFQKBGNRLFZ-UHFFFAOYSA-N vitamin p Natural products O1C2=CC=CC=C2C(=O)C=C1C1=CC=CC=C1 VHBFFQKBGNRLFZ-UHFFFAOYSA-N 0.000 description 1
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
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- A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
- A23L29/10—Foods or foodstuffs containing additives; Preparation or treatment thereof containing emulsifiers
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
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- Y02A40/00—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production
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Abstract
An antioxidant composition comprises quercitrin and gallic acid component, wherein the gallic acid component is gallic acid and/or its derivatives. The quercetagetin and the gallic acid are compounded and used according to a proper proportion, so that the synergistic effect is obvious, the antioxidant effect can be obviously improved, and the stability of products such as food, feed, medicines and the like is ensured.
Description
Technical Field
The invention belongs to the field of additives, and particularly relates to an antioxidant composition containing quercetagetin and gallic acid and application thereof.
Background
In the process of placing foods, feeds, medicines and the like, effective components such as grease, vitamins, carotenoids and the like in the foods can generate oxidation reaction, so that the content of the effective components is reduced, and the quality of the products is seriously influenced. Wherein the fat can cause fat deterioration and generate peculiar smell. Carotenoid is the main source of vitamin A in vivo, and also has effects of resisting oxidation, regulating immunity, resisting cancer, delaying aging, etc. Because the molecular structure contains a large number of double bonds, oxidation reaction is easy to occur and loss is easy to occur. Vitamins are a kind of trace organic substances which must be obtained from food for human and animals to maintain normal physiological functions, and play an important role in the growth, metabolism and development processes of human bodies. Most of the vitamins such as VA, VC and the like are easy to oxidize and deteriorate in the standing process, so that the content loss is caused.
To prevent oxidative loss of the active ingredient, the addition of antioxidants is currently a commonly used method. Commercially available antioxidants are mainly chemically synthesized, such as TBHQ (tert-butylhydroquinone), BHA (butylhydroxyanisole), BHT (dibutylhydroxytoluene), EQ (ethoxyquinoline), and the like. EQ is one of the feed antioxidants with excellent performance and is the antioxidant with the highest cost performance. Besides being applied to feeds, TBHQ, BHA, BHT and the like can also be applied to the fields of food and the like. Synthetic antioxidants such as EQ and BHT have low cost, but have different safety problems generally, and the application of products is limited to a certain extent.
Quercetin, chemical name is 3,3,4,5,6, 7-hexahydroxyflavone, has important pharmacological actions such as antioxidation, anti-inflammatory, antiallergic, antitumor, etc., and has good antioxidant effect.
Gallic acid is a polyphenol compound existing in nature, and can be widely applied in fields of food, biology, medicine, chemical industry, etc. In addition, gallic acid is also often present in the form of its derivatives, which mainly include gallic acid salts, gallic acid esters, and gallic acid glycosides.
When in use, different antioxidants are reasonably matched and used, and sometimes have a synergistic effect. The application finds that the quercetagetin and the gallic acid component are compounded and used according to a certain proportion, so that the quercetagetin and the gallic acid component have obvious synergistic interaction effect, the oxidation process of the effective components of the product can be effectively delayed, and the stability of the product quality is ensured.
Disclosure of Invention
In order to further improve the antioxidant effect and safety of the antioxidant additive, the invention provides the antioxidant composition containing the quercetagetin and the gallic acid component.
The technical scheme adopted by the invention for solving the technical problems is as follows: an antioxidant composition comprises quercetin and gallic acid.
The application further provides an antioxidant composition, wherein the weight ratio of the quercetagetin to the gallic acid in the composition is 300:1-70: 1; can be preferably 200:1-80: 1; further preferably from 150:1 to 100: 1.
Further, the weight ratio of quercetagetin to gallic acid component may be 150:1, 149:1, 148:1, 147:1, 146:1, 145:1, 144:1, 143:1, 142:1, 141:1, 140:1, 139: 1. 138:1, 137:1, 136:1, 135:1, 134:1, 133:1, 132:1, 131:1, 130:1, 129:1, 128:1, 127:1, 126:1, 125:1, 124:1, 123:1, 122:1, 121:1, 120:1, 119:1, 118:1, 117:1, 116:1, 115:1, 114:1, 113:1, 112:1, 111:1, 110: 1. 109:1, 108:1, 107:1, 106:1, 105:1, 104:1, 103:1, 102:1, 101:1, 100:1, 99:1, 98:1, 97:1, 96:1, 95:1, 94:1, 93:1, 92:1, 91:1, 90:1, 89:1, 88:1, 87:1, 86:1, 85:1, 84:1, 83:1, 82:1, 81:1, 80:1, 79:1, 78:1, 76:1, 75:1, 74:1, 73:1, 72:1, 71:1, or 70: 1.
Further, the gallic acid component is gallic acid and/or a derivative thereof; preferably, the gallic acid derivative is any one or more of a gallate, a gallic acid ester, or a gallic acid glycoside.
Furthermore, the antioxidant composition also comprises one or more components such as a suitable carrier, a metal ion chelating agent, an emulsifier, and the like.
The antioxidant composition can be used as additive, and can be added into food, feed, nutritional health product or medicine to ensure stability of product quality.
The antioxidant composition can be used as an additive, can effectively delay the oxidation process of each component in food, feed, cosmetics, nutritional health products or medicines, and ensures the stability of the product quality.
The antioxidant composition can effectively delay the oxidation process of components such as grease, vitamins, carotenoids and the like, and ensure the stability of the components.
The application also provides an additive preparation, namely the composition is prepared into any acceptable appropriate preparation according to a conventional preparation method, and the acceptable appropriate preparation can be preferably processed into powder, liquid or microcapsule.
The additive preparation can effectively delay the oxidation process of components such as grease, vitamins, carotenoids and the like, and ensure the stability of the components.
The additive preparation can be added into food, feed, cosmetics, nutritional health product, and medicine to ensure stability of product quality.
The invention has the beneficial effects that:
the inventor of the application finds that when the quercetagetin and the gallic acid are compounded according to a certain proportion, the quercetagetin and the gallic acid have obvious synergistic effect, under the same additive amount, the protection effect of the composition containing the quercetagetin and the gallic acid matched according to a certain proportion on grease, vitamins, carotenoids and the like in food, feed, cosmetics, nutritional health products or medicines is obviously better than that of the composition containing the quercetagetin and the gallic acid used alone, the oxidation process of each component in the food, the feed, the cosmetics, the nutritional health products or the medicines can be delayed, and the stability of the product in the storage process is ensured.
Quercetin and gallic acid components are natural products widely existing in plants, and are superior to conventional synthetic antioxidants in product safety. The natural flavone and polyphenol components can delay the oxidation of the product, and also have the effects of scavenging free radicals, resisting inflammation, resisting tumor and the like in human bodies and animal bodies, thereby being beneficial to the health of human bodies and animals.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more apparent, the present invention is further described in detail with reference to the following embodiments. It should be understood that the specific embodiments described herein are merely illustrative of the invention and are not intended to limit the invention.
Example 1
The antioxidant composition of example 1 was prepared by mixing the following raw materials in proportions: 150g of quercetagetin with the content of 80% and 1g of gallic acid with the content of 80%, and mixing to obtain 151g of composition, wherein the weight ratio of the quercetagetin to the gallic acid in the composition is 150: 1.
Example 2
The antioxidant composition of example 2 was prepared by mixing the following raw materials in proportions: 300g of quercetagetin with the content of 80%, 1g of gallic acid with the content of 80% and 100g of carrier silicon dioxide are mixed to obtain 401g of composition, and the weight ratio of the quercetagetin to the gallic acid in the composition is 300: 1.
Example 3
The antioxidant composition of example 3 was prepared by mixing the following raw materials in proportions: 70g of 80% quercetin marigold, 1g of 80% gallic acid and 30g of carrier silicon dioxide, and mixing to obtain 101g of composition, wherein the weight ratio of quercetin marigold and gallic acid in the composition is 70: 1.
Example 4
The antioxidant composition of example 1 was prepared by mixing the following raw materials in proportions: 100g of quercetagetin with the content of 80% and 1g of gallic acid with the content of 80% are mixed to obtain 101g of a composition, and the weight ratio of the quercetagetin to the gallic acid in the composition is 100: 1.
Comparative example 1
Quercetin in an amount of 80%.
Comparative example 2
Gallic acid content of 80%.
Comparative example 3
The antioxidant composition of comparative example 3 was prepared by mixing the following raw materials in proportions: mixing 50g of 80% quercetin and 1g of 80% gallic acid to obtain 51g of composition, wherein the weight ratio of quercetin to gallic acid in the composition is 50: 1.
Comparative example 4
The antioxidant composition of comparative example 4 was prepared by mixing the following raw materials in proportions: 500g of quercetagetin with the content of 80%, 1g of gallic acid with the content of 80% and 100g of carrier silicon dioxide are mixed to obtain 601g of composition, and the weight ratio of the quercetagetin to the gallic acid in the composition is 500: 1.
Taking a feed as an example, the antioxidant effect evaluation is carried out:
1. a sample preparation step:
(1) crushing the soybean meal for later use;
(2) self-made premix formula (CuSO)4 40％+FeSO4 30％+MnSO4 20％+Zn SO410%) of SiO was added in equal amounts2Fully and uniformly mixing by using a grinder;
(3) the feed (92% of soybean meal + 1% of premix + 7% of soybean oil) was prepared by adding the antioxidants of examples 1 to 4 and comparative examples 1 to 4, respectively, to prepare 8 groups of samples each having an antioxidant content of 300ppm, wherein the antioxidant content was calculated as the total content of antioxidant active ingredients. A blank control group was additionally set. Each group is repeated three times, and all samples are placed in a beaker in an open manner after being uniformly mixed;
2. evaluation indexes are as follows: peroxide number
3. Storage and detection conditions: each group of samples was placed in a stability testing cabinet at 50 ℃ and 70% humidity for 5 days.
The peroxide value in each sample was measured after 5 days of standing under the above storage conditions. The detection is carried out according to the method of GB5009.227-2016 determination of peroxide value in food safety national standard food.
The results are shown in Table 1.
TABLE 1 peroxide number determination of feeds with different antioxidant compositions
The results in Table 1 show that the antioxidant effect of the specific proportions of quercetin and gallic acid composition according to the present application is superior to that of quercetin and gallic acid alone or other proportions of quercetin and gallic acid at the same dosage.
Claims (10)
1. An antioxidant composition is characterized by containing quercetin marigold and gallic acid, wherein the weight ratio of the quercetin marigold to the gallic acid is 300:1-70: 1.
2. The antioxidant composition of claim 1, wherein the weight ratio of quercetin to gallic acid in the composition is 200:1-80: 1.
3. The antioxidant composition of claim 2, wherein the weight ratio of quercetin to gallic acid in the composition is 150:1-100: 1.
4. Antioxidant composition according to any of claims 1-3, characterized in that the gallic acid component is gallic acid and/or derivatives thereof, preferably the gallic acid derivative is one or more of a gallate or an ester or a glycoside.
5. A composition according to any one of claims 1 to 4, which further comprises one or more ingredients selected from the group consisting of suitable carriers, metal ion sequestrants, emulsifiers and the like.
6. An additive formulation comprising a composition according to any one of claims 1 to 5 and prepared according to any one of the conventional formulation methods, preferably the formulation is prepared as a powder, liquid or microcapsule.
7. Use of the antioxidant composition according to any of claims 1-5 as an additive to food, feed, cosmetics, nutraceuticals, pharmaceuticals to ensure product stability.
8. Use of an antioxidant composition according to any of claims 1-5 for retarding the oxidation process of components like fats and oils, vitamins, carotenoids etc.
9. Use of the additive preparation according to claim 6 for retarding the oxidation process of active principles in food, feed, cosmetics, nutraceuticals, pharmaceuticals.
10. Use of the additive formulation according to claim 6 for retarding the oxidation process of oils, vitamins, carotenoids etc.
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