CN103948857A - Pharmaceutical composition after chronic nasosinusitis endoscopic sinus surgery - Google Patents

Abstract

The invention discloses a pharmaceutical composition after chronic nasosinusitis endoscopic sinus surgery. The pharmaceutical composition is prepared from the following raw materials (active components) in parts by weight: 24-36 parts of radix astragali, 24-36 parts of tuckahoe, 10-20 parts of amomum fruit, 10-20 parts of coix seed, 10-20 parts of rhizoma atractylodis macrocephalae, 10-20 parts of radix paeoniae alba, 6-14 parts of wrinkled gianthyssop, 6-14 parts of eupatorium, 7-13 parts of Japanese sweetflag, 7-13 parts of skunk bugbane, 7-13 parts of radix angelicae, 4-8 parts of honey-fried licorice root and 2-6 parts of dried orange peel. The invention overcomes the defects of medicines after the existing chronic nasosinusitis endoscopic sinus surgery, and provides a pharmaceutical composition with favorable effects after chronic nasosinusitis endoscopic sinus surgery.

Description

Pharmaceutical composition after a kind of chronic sinusitis nasal endoscope operation

Technical field

The present invention relates to technical field of Chinese medicines, be specifically related to a kind of for the pharmaceutical composition after chronic sinusitis nasal endoscope operation.

Background technology

Chronic sinusitis is common clinical, frequently-occurring disease, and main manifestations is the symptoms such as nasal obstruction, watery nasal discharge, dizziness, a vexed pain, hyposmia, absent minded, hypomnesis, has a strong impact on patient's study, life.The morbidity of chronic sinusitis is the coefficient result of multiple paathogenic factor, comprise that local pathogenic infection, body allergy increase, microcirculation disturbance mouth sinotunnel c omplex deformity and general immunity power low inferior, cause nasal mucosa edema, thicken and Polypoid changes, Cystic changes, or proliferation of fibrous tissue, angiemphraxis, body of gland atrophy, mucosal atrophy.In treatment doctor trained in Western medicine be mainly symptomatic treatment as: local drip medicine (conventional vasoconstrictor collunarium and corticosteroid hormone, improve nasal airflow) and drain; After regular expectant treatment is invalid, can adopt nasal cavity disease surgery to remove the obstruction of middle nasal meatus and near zone thereof, improve nasal sinuses drain and ventilation, promote disappearing of nasal sinuses inflammation, as middle nasal concha, partial inferior turbinectomy and diorthosis for deflection of nasal septum art etc.

Endoscopic Sinus Surgery is to treat at present chronic sinusitis, polypous effective method, but the complexity lapsing to due to multiformity and the pathophysiology of the cause of disease, postoperative nasal endoscopic, art intracavity exist undesirable element as infect in art chamber, operating position occurs that granulation, vesicle, myxedema, mucociliary clearance system function are impaired, ischesis etc., affect the recovery of wound surface and mucosa, for the recovery of wound surface and mucosa, Follow-up After and Comprehensive Treatment are important rings.At present clinically, postoperative normal saline, injection liquid of gentamicin and the dexamethasone injection flush operation chamber of adopting more, have that nasal cavity retention time is short, medicinal liquid easily evaporates, the antibiotic application such as the dry and long-term hormone of nasal cavity, gentamycin is easily to shortcomings such as human body have side effects, and after still having more operation in patients after using, there is the pathological changes such as mucosa edema, vesicle, granulation, polyp regeneration and adhesion of nasal cavity, cause operative failure.Postoperative nasal endoscopic is except nasal cavity cleaning is changed dressings, and routine is applied the treatments such as intranasal hormone, antibiotic and antihistaminic, but price is more expensive, and long-time medication brings complication and side effect to patient.Select the pharmaceutical composition after suitable chronic sinusitis nasal endoscope operation, by the efficiency that contributes to improve the cleaning of art chamber and rinse, promote mucosal epithelium and functional rehabilitation, the time of desmopyknosis chamber healing.

Summary of the invention

The technical problem to be solved in the present invention is to overcome the existing deficiency for the medicine after chronic sinusitis nasal endoscope operation, and the pharmaceutical composition after a kind of chronic sinusitis nasal endoscope operation is provided.

In pharmaceutical composition of the present invention, the consumption of each component is that inventor draws through a large amount of practice summaries, is made up of the raw material of following weight parts:

Radix Astragali 24-36 part, Poria 24-36 part, Fructus Amomi 10-20 part, Semen Coicis 10-20 part, Rhizoma Atractylodis Macrocephalae 10-20 part, Radix Paeoniae Alba 10-20 part, Herba Pogostemonis 6-14 part, Herba Eupatorii 6-14 part, Rhizoma Acori Graminei 7-13 part, Rhizoma Cimicifugae 7-13 part, Radix Angelicae Dahuricae 7-13 part, Radix Glycyrrhizae Preparata 4-8 part, Pericarpium Citri Reticulatae 2-6 part.

Preferably, it is to be made up by weight of following raw materials according:

Radix Astragali 27-33 part, Poria 27-33 part, Fructus Amomi 12-18 part, Semen Coicis 12-18 part, Rhizoma Atractylodis Macrocephalae 12-18 part, Radix Paeoniae Alba 12-18 part, Herba Pogostemonis 8-12 part, Herba Eupatorii 8-12 part, Rhizoma Acori Graminei 6-12 part, Rhizoma Cimicifugae 6-12 part, Radix Angelicae Dahuricae 6-12 part, Radix Glycyrrhizae Preparata 5-7 part, Pericarpium Citri Reticulatae 3-5 part.

More preferably, it is to be made up by weight of following raw materials according:

30 parts of the Radixs Astragali, 30 parts, Poria, 16 parts of Fructus Amomis, 15 parts of Semen Coiciss, 15 parts of the Rhizoma Atractylodis Macrocephalaes, 15 parts of the Radix Paeoniae Albas, 10 parts of Herba Pogostemoniss, 10 parts of Herba Eupatoriis, 9 parts of Rhizoma Acori Graminei, 9 parts of Rhizoma Cimicifugaes, 9 parts of the Radixs Angelicae Dahuricae, 6 parts of Radix Glycyrrhizae Preparatas, 4 parts of Pericarpium Citri Reticulataes.

The dosage form of pharmaceutical composition of the present invention can be the medically acceptable dosage forms such as capsule, tablet, spray, decoction, and their preparation method, supplementary product consumption are undertaken by existing common process.

The present invention also comprises the application of aforementioned pharmaceutical compositions in the medicine for the preparation of after chronic sinusitis nasal endoscope operation.

In pharmaceutical composition prescription of the present invention:

The Radix Astragali, another name Radix Astragali, continuous stilbene, the continuous Radixs Astragali etc. are dry of the universe of leguminous plant Radix Astragali Astragalus membranaceus (Fisch.) Bge. or Radix Astagali Astragalus membranaceus (Fisch.) Bge.Var.mongholicus (Bge.) Hsiao.Composition: mainly contain saponin, flavone etc.Saponin main component is astragaloside I, II, and Radix Astragali is separately containing Radix Astragali saponin A, B, and Radix Astagali is separately containing ASI, Sayasaponin Ⅰ; In flavone, main component is formononetin and calycosin etc.Still containing aminoacid, betanin etc.; Radix Astagali is also containing astragalus polysaccharides I, II, III etc.Function cures mainly: invigorating QI to consolidate the body surface resistance, expelling pus and toxin by strengthening QI, diuresis, granulation promoting.For weak, the chronic diarrhea proctoptosis of the deficiency of vital energy, spontaneous perspiration, edema, sub-official's prolapsus, chronic nephritis proteinuria, diabetes, open sore part disunion of a specified duration.

Poria, another name: lying prostrate tire, Poria, Fu rabbit, loose potato, Maninot esculenta crantz., Song Ling in Fu Tu, Poria, Fu Ling, Fu Ling, volt Tu, loose fat, deep red morning, is the dry sclerotia of Polyporaceae plant Poria.Composition: sclerotium, containing β-pachyman, accounts for dry weight 93% and triterpenoid compound Pachymic acid, pachymic acid, 3 beta-hydroxy Pilus Caprae seu Ovis steroid trienic acids.In addition still gummy, chitin, protein, fat, sterol, lecithin, glucose, adenine, histidine, choline, β-pachyman catabolic enzyme, lipase, protease etc..Function cures mainly: eliminating dampness and diuresis, strengthening the spleen stomach function regulating, mind tranquilizing and the heart calming.Control dysuria, edema distension, phlegm retention cough with dyspnea, the sound of vomiting of vomitting, has loose bowels, seminal emission, stranguria with turbid discharge, palpitation with fear, forgetful.1. " herbal classic ": " the contrary gas of the main breast side of body, melancholy is angerd frightened heresy and probably throbbed with fear, knot pain under the heart, cold and heat stuffy sensation with restlessness, cough with dyspnea, mouthful burnt dry tongue, diuresis." 2. " not Lu ": " and only quench one's thirst, like to sleep, large abdomen, drenches drop, the disease due to obstruction of QI of middle-JIAO expectorant water, and edema is drenched knot.Open breast internal organs, adjust visceral-qi, cut down kidney heresy, long cloudy, physical strength profiting, during guarantor god keeps." 3. " property of medicine opinion ": " appetizing, preventing or arresting vomiting is contrary, kind tranquilizing mind.Main consumptive lung disease expectorant is stopped up.Control pediatric epilepsy scared, trusted subordinate's distension, married woman's pyretic stranguria." 4. " Japan hanako materia medica ": " and mend five kinds of strain and seven kinds of impairment, antiabortive, warm waist knee joint, happy Fructus Alpiniae Oxyphyllae, only forgetful." 5. " concise exposition on febrile disease ": " the slow spleen of infiltration." 6. " medicine origin ": " and dehumidifying, blood between sharp waist umbilicus, and middle QI invigorating is main.Control the Huang or red and unfavorable of drowning." curing mainly secret formula " cloud, antidiarrheal, except deficiency-heat, loosing the interspaces of skin and muscles, born fluid." 7. Wang Haogu: " rush down bladder, strengthening the spleen stomach.Control the long-pending renal mass of kidney.It is cautious that " 8. " modality ": " cures mainly the Ji Rou Shun muscle of throbbing with fear, and dizziness agitation is controlled on side.”

Fructus Amomi, another name: contracting Fructus Amomi, contracting sand honey (" property of medicine opinion "), Amomum xanthioides (" Haiyao Bencao, Oversea Materia Medica ") they are mature fruit or the seed of zingiberaceous plant Fructus Amomi or contracting sand.Composition: contracting sand seed is containing volatile oil 1.7-3%, and main component is d-Camphora, a kind of terpenes (like limonene, but non-limonene), d-Borneolum Syntheticum, borneol acetate, linalool, nerolidol.Fructus Amomi, the volatile oil of leaf is similar to the volatile oil of seed, containing compositions such as Borneolum Syntheticum, borneol acetate, Camphora, limonenes.Fructus Amomi is containing Saponin 0.69% again.Congener Semen Alpiniae Katsumadai, the volatile oil 4-6% that its seed contains Fructus Amomi fragrance.Function cures mainly: during circulation of qi promoting is adjusted, stomach function regulating, is amusing.Control stomachache painful abdominal mass swollen, anorexia dyspepsia, dysphagic vomiting, diarrhea due to cold pathogen cold-dysentery, pregnant fetal movement.1. " property of medicine opinion ": " main cold air stomachache, only rest diarrhea due to disorder of qi, strain, the digesting and absorbing the essence of foodstuff that disappears, warm taste." 2. supplement to the Herbal: " cough of Your Majesty's gas, renal mass, infantile convulsion pathogen." 3. " Japan hanako materia medica ": " control all gas, cramp caused by acute vomiting and diarrhea, cardiac and abdominal pain." 4. Zhang Yuansu: " control taste depressed stagnant loose." 5. Yang Shiying: " and with in, circulation of qi promoting, pain relieving, antiabortive." 6. " book on Chinese herbal medicine covers bamboo fish trap ": " only feel sick, but stomachache." 7. " detailed outline ": " and tonifying the lung is amusing, nourishing the stomach kidney tonifying, and reason vigour, dispelling stagnant Qi, cold expelling time swollen painful abdominal mass, dysphagic vomiting, only woman's metrorrhagia, except throat ability to speak superficial heat, changes copper gagger and chokes." 8. " medical center bun is wanted ": " profit kidney, tonifying liver, mends the gate of vitality, and taste, relieving stagnation.”

Semen Coicis, have another name called: separating calabash shell serving as a dipper, an English, Jiangxi rice, sense rice, heart of a lotus seed pearl, jobstears, careless bead, Jiangxi pearl, Semen Coicis, Semen Coicis, Semen Coicis, Semen Coicis, beautiful fodder, NLIUGU rice, pearl pearl rice, jobstears, water Semen Maydis, ditch rice, abundant rice, beneficial rice, is grass family Coix.Composition: containing coixenolide (coixenolide), crude protein 13-14%, lipid 2-8%.Triacylglycerol 61-64% in lipid, diacylglycerol 6-7%, monoacylglycerol 4%, sterol ester 9%, free fatty 17-18%.Linoleic acid in triacylglycerol (linoleic acid) content can reach 25-28%, in free fatty, linoleic acid content is 27-28%, free fatty also has Palmic acid (palmitic acid), stearic acid (stearic acid), cis-8-octadecenoic acid (cis-8-oc-tadecenoic acid) is oleic acid etc.In monoacylglycerol, there is the & alpha of tool antitumor action; Glyceryl monooleate (& alpha-monoolein), has cis-, trans-Resina Ferulae acyl stigmasterol (cis-, trans-feruloylstigmasterol) and cis-, the trans-Resina Ferulae acyl campesterol (cis-, trans-feruloylcampesterol) etc. of tool ovulation effect in sterol ester.Kernel is also containing the glucosan of anticomplementary action and Semen Coicis polysaccharide (coixan) A, B, the C of acidic polysaccharose CA-1, CA-2 and hypoglycemic activity.Volatile Oil from Seed is containing 69 kinds of compositions, wherein main have aldehyde (hexanal), acid (hexanoic acid), 2-ethyl 3 hydroxy butyrate is ester (2-ethyl-3-hydroxy-hexylbutrate), & gamma;-nonalactone (& gamma;-nonalactone), n-nonanoic acid (nonanoic acid), sad (octanoic aid), ethyl palmitate (ethylpalmitate), methyl linoleate (methyllinoleate), vanillin (vanillin) and Ethyl linoleate (ethyllinoleate) etc.Protein, vitamin B1, B2.Function cures mainly: spleen invigorating, tonifying the lung, heat clearing away, dampness removing.Control and have loose bowels, arthralgia chiefly caused by damp pathogen, the contracture of muscle arteries and veins, joint stuffiness, edema, beriberi, consumptive lung disease, lung abscess, acute appendicitis, stranguria with turbid discharge, leucorrhea.1. " herbal classic "; " main muscular contracture contracture, unable to flex and stretch the extremities, rheumatism numbness, the therapeutic method to keep the adverse QI flowing downwards." 2. " not Lu ": " and except muscles and bones pathogen meciless, sharp the intestines and stomach, consumer edema, makes us eating." 3. " property of medicine opinion ": " main consumptive lung disease lung qi, vomiting bloody pus, the upper gas of cough tears saliva.The small stream poison fifth day of the first lunar month of decoction is swollen." 4. " Treatise on Dietetic Therapy ": " remove dry beriberi caused by pathogenic damp." 5. supplement to the Herbal: " wet, main quenching one's thirst." " kill ascarid." 6. " Elementary Medicine ": " Your Majesty's gas, ambition first mistake." 7. " detailed outline ": " invigorating spleen and reinforcing stomach, tonifying the lung heat clearing away, removes wind prevailing over dampness.The food of cooking a meal, controls cold air; Decoct drink, diuresis pyretic stranguria." 8. " pharmacologys of traditional Chinese medicines ": " control hydrops in stomach." 9. " middle traditional Chinese medicines are planted illustrated handbook ": " control pulmonary edema, moist pleuritis, dysuria, Chronic gastrointestinal disorders, chronic ulcer.”

The Rhizoma Atractylodis Macrocephalae, is the dry rhizome of the feverfew Rhizoma Atractylodis Macrocephalae (Atractylodes macrocephala Koidz.), Rhizoma Atractylodis Macrocephalae perennial herb, and the nice and cool weather of happiness, is used as medicine with rhizome, has multinomial medicinal function.Effect: invigorating the spleen and benefiting QI, dampness diuretic, hidroschesis, antiabortive.For insufficiency of the spleen lack of appetite, abdominal distention is had loose bowels, phlegm retention vertigo and palpitation, edema, spontaneous perspiration, frequent fetal movement.Meridian distribution of property and flavor: bitter, sweet, temperature.Return spleen, stomach warp.

The Radix Paeoniae Alba, another name: golden Radix Paeoniae (" the raw refining method that takes of Anqi "), the Radix Paeoniae Alba (" medicine "), is the root of ranunculaceae plant Radix Paeoniae (cultigen).Composition: root is containing paeoniflorin, paeonol, paeoniflorin, benzoic acid approximately 1.07%, volatile oil, fatty oil, resin, tannin, sugar, starch, phlegmatic temperament, protein, cupreol and triterpenes, another Sichuan product person, containing a kind of acidic materials, has inhibitory action to staphylococcus aureus.Flower is containing astragalin, nimbecetin 3,7-diglucoside, volume gallotannin (more than 10%), pyrethrin 0.13%, 13-methyl tetradecanoic acid, cupreol, pentacosane etc.Leaf is containing tannin.Function cures mainly: nourishing blood to suppress the hyperactive liver, and slow middle pain relieving, yin fluid astringing is received antiperspirant.Control the breast abdomen pain over the hypochondriac region, dysentery stomachache, spontaneous sweating, fever due to yin deficiency, menoxenia, metrorrhagia, leukorrhagia.1. " herbal classic ": " main pathogen stomachache, except arthralgia due to stagnation of blood, broken hard long-pending, control cold and heat hernia abdominal mass, pain relieving, diuresis, QI invigorating." 2. " not Lu ": " and clear and coherent blood vessels, slow in, dispelling malignant blood, expelling extravasated blood, the gas that anhydrates, sharp bladder, intestine and small intestine, subduing inflammation, row cold and heat when (controlling), attacked by pestiferous factors stomachache, lumbago." 3. " property of medicine opinion ": " and control pathogen of the lung gas, Fu Zhong Xu pain, vim and vigour are gathered, and logical a surname's internal organs are gathered around gas, control evil pain deteriorated blood, disease bone heat when main, strong the five internal organs, the kidney invigorating gas, controls trusted subordinate's heavily fortified point swollen, and married woman's blood closes obstructed, and repercussive blood can lose pus." 4. Tang Materia Medica: " beneficial woman's blood." 5. " Japan hanako materia medica ": " and control wind and mend consumptive disease, all diseases of main woman, and antenatal rear all diseases, Tong Yueshui, the relieving restlessness of bringing down a fever, QI invigorating, controls a day capable hot disease, pestilence miasma mania and irritation, married woman's blood fortune, and hemorrhoidal hamorrhage rushes down blood, hemorrhoid complicated by anal fistula carbuncle on the back, skin ulcer scabies, headache, improving eyesight, conjunctival congestion, bulbar conjunctiva polyp." 6. " medicine origin ": " peace spleen channel, controls stomachache, receives gastric qi, antidiarrheal profit, and blood, fixing striae, eliminating pathogen in the liver, tonifying the spleen and stomach." 7. Wang Haogu: " and gas in reason, controls abdominal flatulence due to deficiency of the spleen, epigastric oppression, and pain over the hypochondrium, frequent eructation, lung is anxious swollen contrary breathing with cough, sun rhinallergosis and epistaxis, order is puckery, deficiency of liver-blood, sun dimension suffering of illness cold and heat, dai channel suffering of illness stomachache is full, and waist is broad as sit in water." 8. " the southern regions of the Yunnan Province book on Chinese herbal medicine ": " sealing rushes down, and receives adverse flow of liver-QI pain, takes good care of conscience spleen channel blood, relaxes through sending down the abnormal ascending QI, only irritability pain for purgation of spleen excess heat, only abdomen pain.”

Herba Pogostemonis is the herb of labiate Herba Pogostemonis or Herba Pogostemonis.Composition: Herba Pogostemonis is containing volatile oil approximately 1.5%, and in oil, main constituent is patchouli alcohol, accounts for 52-57%; Other compositions have benzaldehyde, eugenol, cinnamic aldehyde pogostol, patchouli pyridine, epiguaipyridine; Separately there are multiple other sesquiterpenes as caryophyllene, beta-elemene, alloaromadendrene, γ-patchoulene, β-gurjunene, α-guaiene, valencene, α-gurjunene, γ-Cadinene, δ-guaiene, α-patchoulene, (-)-Cadina-1,3,5-triene etc.Herba Pogostemonis is containing volatile oil 0.28%, main component is estragole, account for more than 80%, and contain methoxybenzene, anisaldehyde, (R)-4-isopropenyl-1-methyl-1-cyclohexene, and p-methoxyl group cinnamic aldehyde, australene, nopinene, octanone-3, capryl alcohol-3, cymol, octen-1-ol-3, linalool, l-caryophyllene, beta-elemene, β-Humuleno, ylangene, β-farnesene, γ-Cadinene, (-)-Cadina-1,3,5-triene etc.The air-dry material of Herba Pogostemonis is produced in China northeast, and herb contains volatile oil 0.54%, and containing micro-tannin and amaroid.Function cures mainly: fast gas, and in, ward off dirty, damp eliminating, the heat-damp in summer that cures cold, cold and heat, headache, breast gastral cavity painful abdominal mass is vexed, vomiting is had loose bowels, malaria, dysentery, halitosis.1. not " not Lu ": " treat edema due to wind pathogen poison swollen, remove bad odor, treat cholera, pained." 2. " Bencao Tujing ": " controlling taste and tell contraryly, is the medicine of wanting most." 3. " pearl sac ": " benefit is defended gas, and stomach reinforcing gas, enters diet, controls again and tells contrary cholera." 4. Materia Medica of Decoction: " the fast gas of warming middle-JIAO.The deficiency of the lung has cold, and the part of the body cavity above the diaphragm housing the heart and lungs is stopped up heat, and the halitosis of drinking, decocts soup and gargle." 5. " book on Chinese herbal medicine is stated ": " cold expelling is wet, heat-damp in summer, hot and suffocating, damp and hot.Control diseases caused by exogenous pathogenic factor cold-evil, internal injury diet, or diet hinders cold humidity hysteresis, epidemic pathogenic factors from mountains, and not FUSHUI soil, cold and heat are done the diseases such as malaria." 6. " book on Chinese herbal medicine is new again ": " inducing diaphoresis to expel pathogens, dampness removing, except wind, relieves heat and thirst.Stopping vomiting is told cholera, malaria, dysentery, skin ulcer scabies.Stalk: can control sore throat, reduce phlegm, cough-relieving coughs.”

Herba Eupatorii, another name: fennel (" Book of Songs "), blue (" Mao Shichuan "), Herba Chlorophyti, water perfume (or spice) (" herbal classic "), Dou Liangxiang (Lee is when it " medicine record "), great zeeland (Lei Gong's Treatise on Preparation and Broiling of Materia Medica), dovetail perfume (or spice), perfume orchid (" Kaibao Bencao "), Hai Erju, a thousand pieces of gold grass (" continuous Textual Research "), Ocimum basilicum L. var. pilosum (" Tang Yao is through proved recipe "), female orchid, Rhizoma et radix valerianae (" detailed outline "), wake up head grass (" must join book on Chinese herbal medicine "), stone lobe, backshank phoenix (" Guangdong Chinese medicine ") are the stem and leaf of feverfew Herba Chlorophyti.Composition: Herba Chlorophyti herb containing volatile oil 1.5-2%, contains in oil: cymol neryl acetate and 5-methyl Herba thymi vulgaris ether, the above two infected by influenzas have direct repression.Leaf is containing coumarin, o-coumaric acid and thymohydroquinone.The leaf of agrimony, all contains eupatoriopicrin and half as much again terpene lactones in spending, contain again Herba Lycopi's glycoside in leaf.In the root of above-mentioned two kind of plant, all contain euparin.Function cures mainly: clearing away summer-heat, ward off dirty, removing dampness, regulating menstruation.Control and experience heat-damp in summer, cold and heat headache, accumulates in damp, and gastral cavity painful abdominal mass is not hungry, sweet taste in the mouth greasy fur, menoxenia.1. " herbal classic ": " main dredging water passages, kills diseases due to noxious agents produced by various parasites." 2. " the public big gun of Zhai is processed opinion ": " hemopoietic, regulating QI is with flourish." 3. " not Lu ": " except accumulation of phlegm in the hypochondrium in the heart." 4. " Kaibao Bencao ": " and to boil water to bathe, treat wind." 5. Li Gao: " promoting the production of body fluid to quench thirst, profit muscle.Control the gallbladder of quenching one's thirst (" gallbladder " word is doubted as " spleen " word) illness." 6. " detailed outline ": " subduing inflammation is adjusted menstruation." 7. " modern Practical Chinese medicinal ": " be armaticity stomach invigorating, diaphoresis, diuretic.For common cold headache, nasal obstruction, nervous headache, infectiousness calentura, stomachache, waist nephralgia, calculus etc." 8. " Chinese medicinal herbal ": " deliver damp eliminating, and middleization is turbid.Control summer-heat headache, lossless heating, abdominal distention uncomfortable in chest, sweet greasy in mouthful, halitosis.”

Rhizoma Acori Graminei, another name, prosperous, Chinese onion when Rhizoma Acori Graminei, prosperous sun, prosperous grass, Yao, Yao's fragrant-flowered garlic, haze tallow, spring snow, see disappear, water Rhizoma Acori Graminei, bitter Rhizoma Acori Graminei, powder Chang, Rhizoma Acori Graminei, sword-like leave, Rhizoma Acori Graminei, mountain Rhizoma Acori Graminei, small stream Chang, stone Scolopendra, wild leek, Herba Kyllingae, Rhizoma et radix valerianae, be the rhizome of South, sky section phytobezoar Rhizoma Acori Graminei.Composition: rhizome and Ye Zhongjun are containing volatile oil (0.11-0.42%), and its main component is beta-Asarone 63.2-81.2%, asaricin 8.8-13.7%, is secondly caryophyllene, α-Humuleno, sekishone etc.Also containing aminoacid, organic acid and saccharide.Function cures mainly: have one's ideas straightened out, eliminating phlegm, regulates the flow of vital energy, and invigorates blood circulation, and loose wind, dries.Control epilepsy, syncope due to accumulation of phlegm, calentura coma, forgetful, deafness with qi stagnation, ambition unhappiness, stomachache, stomachache, anemofrigid-damp arthralgia, swollen ulcer drug, traumatic injury.Removing dampness appetizing, the eliminating phlegm of having one's ideas straightened out, refreshment Fructus Alpiniae Oxyphyllae.For not hungry, mouthful dysentery of keeping silent of gastral cavity painful abdominal mass, coma epilepsy, forgetful deafness.1. " herbal classic ": " main anemofrigid-damp arthralgia, cough with dyspnea, happy hole, tonifying five ZANG-organs, logical nine orifices, improve visual and auditory acuity, goes out speech." 2. " not Lu ": " and main deafness, carbuncle skin ulcer, warming intestines and stomach, only normal urination, extremity arthralgia chiefly caused by damp pathogen, must not bend and stretch, children's's pyrexial malaria, body accumulated heat is not understood, and can bathe soup.Audition improvement order, beneficial intelligence." 3. " property of medicine opinion ": " wind syndrome of head, under tear, kills parasites for dispelling the wind and dampness pathogens insensitive impediment, tinnitus, controls malignant boil scabies scabies." 4. " Japan hanako materia medica ": " and except the wind therapeutic method to keep the adverse QI flowing downwards, except unhappy, only cardiac and abdominal pain, cramp caused by acute vomiting and diarrhea.Control objective wind skin ulcer scabies, puckery urine, kills abdomen and hides worm.Otalgia: do end, fry, hold heat and wrap up in basement, very test." 5. Wang Haogu: " control the long-pending volt of heart fine strain of millet." 6. " the southern regions of the Yunnan Province book on Chinese herbal medicine ": " control nine kinds of gastric qis, pain relieves the pain." 7. " detailed outline ": " control attacked by pestiferous factors soldier dead, infantile convulsive seizure due to fright epilepsy, hematochezia metrorrhagia, antiabortive leakage.Loose carbuncle.Smash juice clothes, separate Fructus Crotonis, Radix Euphorbiae Pekinensis poison." 8. essentials of Matea Medica: " the tonifying liver benefit heart, dries by wind, expectorant removing food stagnancy, appetizing alleviating distention in middle-JIAO.The treatment mouthful fulminant dysentery of keeping silent, migratory arthralgia infantile convulsion." 9. " book on Chinese herbal medicine is new again ": " only nose bleeding, loose gingival abscess." 10. Guangzhou army " conventional Chinese herbal medicine handbook ": " treating rheumatic arthritis, lumbago and skelalgia, dyspepsia, gastritis, calentura coma, psychosis." (11) " Guangxi Chinese herbal medicine ": " and control demented, infantile convulsion, coma due to phlegm syncope, the vexed or pain of breast abdominal distention.”

Rhizoma Cimicifugae, calls all Rhizoma Cimicifugaes (" herbal classic "), week fiber crops (" not Lu "), Os Gallus domesticus Rhizoma Cimicifugae (TAO Hong-Jing), funny face Rhizoma Cimicifugae (" detailed outline "), RHIIZOMA CIMICIFUGAE (" medical science is extensively taken down notes ").Medicinal part: be the root stock of ranunculaceae plant Rhizoma Cimicifugae, Cimicifuga Dahurica and C.heracleifolia.Function cures mainly: yang invigorating, deliver rash, removing toxic substances.Control seasonal epidemic pathogens epidemic disease, headache cold and heat, laryngalgia, aphtha, macule is not saturating; Sinking of QI of middle-JIAO, chronic diarrhea chronic dysentery, proctoptosis, women is collapsed, is with, uterus tenesmus; Carbuncle sore tumefacting virus, elevate a turnable ladder yang-energy, getter is unit also, only headache.

The Radix Angelicae Dahuricae, another name: Xue, the root of Dahurian angelica (" Songs of the South "), fragrance (" herbal classic "), membrane inside the rush stalk Li, Ze Fen (" WU Pu Bencao "), white Chai (" not Lu "), Radix Angelicae Dahuricae (Radix Heraclei Scabridi) (" smooth hard will ") is the root of the samphire Xingan Radix Angelicae Dahuricae, angelica anomala, Radix angelicae dahuricae or Yunnan cattle Radix Saposhnikoviae.Composition: containing isoimperatorin (isoimperatorin), imperatorin (imperatorin), bergapton (bergapten), phellopterin (phellopterin), oxypeucedanin (oxypeucedanin) etc.Function cures mainly: dispels the wind, and dampness, detumescence, pain relieving.Control headache, supraorbital bone pain, toothache, nasal sinusitis, cold-damp stomachache, hemorrhoidal hamorrhage anal fistula, leucorrhea with red and white discharge, ulcer sores, skin pruritus due to dryness, scabies.1. " herbal classic ": " main woman's whitish metrorrhagia, blood closes swelling of the vulva, cold and heat, public attention (wind syndrome of head) is invaded order lacrimation, and longue skin is moist." 2. " not Lu ": " treat ailment said due to cold or exposure thirsty (for a long time thirsty or doubt and make " chronic diarrhea ") for a long time, vomiting, fullness sensation in bilateral hypochondrium, wind pain dizziness, eye itching." 3. " property of medicine opinion ": " and control the twinge of trusted subordinate's blood, exorcising, main woman's metrorrhagia and vomiting, improving eyesight, arresting lacrimation go out, and treat married woman's drop blood, waist stomachache; Can lose pus." 4. " Japan hanako materia medica ": " control conjunctival congestion bulbar conjunctiva polyp, and tire patching leakage landing, broken stagnated blood, mends fresh blood, acute mastitis, carbuncle on the back, scrofula, hemorrhoidal hamorrhage, hemorrhoid complicated by anal fistula, and evacuation of pus, desolation, scabies, pain relieving granulation promoting, goes face Shao-defect scar." 5. " the southern regions of the Yunnan Province book on Chinese herbal medicine ": " wind of the skin migration of dispelling, the only cold pain of the cold stomachache of stomach, whole body cold-damp pain." 6. " detailed outline ": " and control nasal sinusitis, epistaxis, toothache, supraorbital bone pain, large intestine constipation due to pathogenic wind, bleeding urine, married woman's blood dizziness due to wind pathogen fortune, regurgitation of food from the stomach is told food; Solution arsenic poison, snakebite, cutter arrow incised wound.”

Radix Glycyrrhizae Preparata, (RADIX GLYCYRRHIZAE PREPARATA), it is leguminous plant, Radix Glycyrrhizae Preparata is with the honey Radix Glycyrrhizae of smoking, and is commonly called as the process of preparing Chinese medicine, Mel is put in pot, be smelt middle honey exactly, using slow fire instead adds Radix Glycyrrhizae sheet and stirs evenly, 3-5min takes the dish out of the pot, and puts 60 DEG C, barn or baking oven and is dried to when tack-free and takes out, and cools.Radix Glycyrrhizae Preparata is similar round or oval section, the brown or taupe brown of surface red, and micro-glossy, tangent plane yellow is to buff, and cambium ring is obvious, ray irradiation shape.Zhigancao decoction has benefiting qi and nourishing yin, and multiple arteries and veins therapeutic efficiency activates yang.

Pericarpium Citri Reticulatae, another name: Pericarpium Citri tangerinae, expensive old, Folium Styracis Suberifoliae, Fructus Citri tangerinae skin, wide Pericarpium Citri tangerinae, Pericarpium Citri tangerinae, Citrus chachiensis Hort. C. Suavissima Tanaka, Pericarpium citri reticuatae chachiensis are the mature peel of rutaceae orange and variety thereof.Nature and flavor: bitter, pungent, temperature.Gui Jing: return lung, spleen channel.Function cures mainly: regulating qi-flowing for strengthening spleen, drying dampness to eliminate phlegm.For fullness in the epigastrium and chest, lack of appetite and vomiting, cough with copious phlegm.

From the angle of the traditional Chinese medical science, chronic sinusitis belongs to Chinese medicine chronic sinusitis category, how to be invaded by exopathogen, causes the pathological changes of lung taste gallbladder and falls ill; Or damage because of the lung spleen deficiency of vital energy, pathogen is controlled for a long time, is detained nose key, so that the touching difficulty of the state of an illness is more, and sickness rate is higher.Chronic sinusitis intranasal videoendoscopic surgery, although can removal lesion tissue, can damage normal structure, not only wasting QI-blood of chronic sinusitis intranasal videoendoscopic surgery, QI and blood deficiency, and easily cause QI and blood cohesion, qi depression to blood stasis; Operation wound and antibiotic, hormone and antihistamine drug application, more rapid wear taste, cause weakness of the spleen and stomach, transformation failure of spleen, QI and blood is precise and tiny biochemical not enough, and nose key loses supports, in addition insufficiency of the spleen can not the lucid yang sending upization turbid, endogenous damp formation, it is many that tired poly-nose key causes nasal mucosa edema, vesicle, secretions.After chronic sinusitis nasal endoscope operation, by following Syndrome Differentiation of Traditional Chinese Medicine: postoperative the 1st week taking deficiency of both QI and blood as main; Postoperative the 2nd week taking syndrome of qi stagnation and blood stasis as master, syndrome of dampness-heat of spleen and stomach are as auxiliary; Postoperative 3-10 week is taking syndrome of dampness-heat of spleen and stomach as master, lung meridian damp-heat syndrome are as auxiliary; After postoperative 10-12 week taking deficiency-weakness of spleen-QI card as main, insufficiency of lung-QI cold syndrome is as auxiliary.

Pharmaceutical composition of the present invention is for the treatment of chronic sinusitis postoperative nasal endoscopic, turbid sensible as main taking spleen invigoratingization, and in side, Radix Codonopsis, the Radix Astragali are returned spleen lung meridian, and invigorating vital QI is monarch drug; The Rhizoma Atractylodis Macrocephalae had both helped the strengthen the spleen and stomach gas of lung of Radix Codonopsis, the Radix Astragali, helped again spleen transporting, was ministerial drug; Poria, Semen Coicis, turbid to ooze dampness removing, and make ginseng, art tonify without causing stagnation, and Fructus Amomi, Herba Pogostemonis, the circulation of qi promoting of Herba Eupatorii removing dampness by means of aromatics, the pungent temperature of Herba Asari enters lung, and warming lung for dispelling cold is adjuvant drug; Radix Glycyrrhizae Preparata coordinating the actions of various ingredients in a prescription, for making medicine, is played effect of the temperature lung and dispelling cold of spleen reinforcing lung altogether.

Detailed description of the invention

With specific embodiment, the invention will be further described below, but the present invention is not limited to these embodiment.

Embodiment 1

Radix Astragali 240g, Poria 360g, Fructus Amomi 100g, Semen Coicis 200g, Rhizoma Atractylodis Macrocephalae 100g, Radix Paeoniae Alba 200g, Herba Pogostemonis 60g, Herba Eupatorii 140g, Rhizoma Acori Graminei 70g, Rhizoma Cimicifugae 130g, Radix Angelicae Dahuricae 70g, Radix Glycyrrhizae Preparata 80g, Pericarpium Citri Reticulatae 20g.

Take above each raw material, decoct with water three times, add the water of doubling dose at every turn, decoct one hour at every turn, filter, merging filtrate, technique is made decoction routinely.

Embodiment 2

Radix Astragali 360g, Poria 240g, Fructus Amomi 200g, Semen Coicis 100g, Rhizoma Atractylodis Macrocephalae 200g, Radix Paeoniae Alba 100g, Herba Pogostemonis 140g, Herba Eupatorii 60g, Rhizoma Acori Graminei 130g, Rhizoma Cimicifugae 70g, Radix Angelicae Dahuricae 130g, Radix Glycyrrhizae Preparata 40g, Pericarpium Citri Reticulatae 60g.

Take above each raw material by proportional quantity, dry, pulverize, cross 80 mesh sieves, soak 2 months with 50 degree rice wine 40kg, filter and remove residue, get supernatant add conventional amount used penetrating agent and antiseptic shake even spray.

Embodiment 3

Radix Astragali 270g, Poria 330g, Fructus Amomi 120g, Semen Coicis 120g, Rhizoma Atractylodis Macrocephalae 180g, Radix Paeoniae Alba 120g, Herba Pogostemonis 120g, Herba Eupatorii 80g, Rhizoma Acori Graminei 120g, Rhizoma Cimicifugae 60g, Radix Angelicae Dahuricae 120g, Radix Glycyrrhizae Preparata 50g, Pericarpium Citri Reticulatae 50g.

Take above each raw material by proportional quantity, decoct with water twice, add for the first time 7 times of water gagings, decoct 1.5 hours, add for the second time 8 times of water gagings, decoct 1.5 hours, collecting decoction, filters, and filtrate is concentrated into relative density be 1.30 extractum of (70 DEG C time survey), the cane sugar powder that adds conventional amount used, mixes granulation.

Embodiment 4

Radix Astragali 330g, Poria 270g, Fructus Amomi 180g, Semen Coicis 180g, Rhizoma Atractylodis Macrocephalae 120g, Radix Paeoniae Alba 180g, Herba Pogostemonis 80g, Herba Eupatorii 120g, Rhizoma Acori Graminei 60g, Rhizoma Cimicifugae 120g, Radix Angelicae Dahuricae 60g, Radix Glycyrrhizae Preparata 70g, Pericarpium Citri Reticulatae 30g.

Take above each raw material by proportional quantity, decoct with water twice, add for the first time 7 times of water gagings, decoct 1.5 hours, add for the second time 8 times of water gagings, decoct 1.5 hours, collecting decoction, filters, filtrate is concentrated into relative density be 1.30 extractum of (70 DEG C time survey), the magnesium stearate adjuvant that adds conventional amount used, technique becomes tablet routinely, specification 0.5g/ sheet.

Embodiment 5

Radix Astragali 300g, Poria 300g, Fructus Amomi 160g, Semen Coicis 150g, Rhizoma Atractylodis Macrocephalae 150g, Radix Paeoniae Alba 150g, Herba Pogostemonis 100g, Herba Eupatorii 100g, Rhizoma Acori Graminei 90g, Rhizoma Cimicifugae 90g, Radix Angelicae Dahuricae 90g, Radix Glycyrrhizae Preparata 60g, Pericarpium Citri Reticulatae 40g.

Take above each raw material by proportional quantity, decoct with water twice, add for the first time 7 times of water gagings, decoct 1.5 hours, add for the second time 8 times of water gagings, decoct collecting decoction 1.5 hours, filter, filtrate is concentrated into relative density be 1.30 extractum of (70 DEG C time survey), adds the dextrin adjuvant of conventional amount used, technique routinely, make capsule, 0.5g/ grain.

Experimental example: pharmaceutical composition of the present invention is for the clinical efficacy of chronic sinusitis postoperative nasal endoscopic

Experiment material: pharmaceutical composition prepared by the embodiment of the present invention 5.

Experiment place: Pubei, Guangxi local hospital.

1, physical data: since 2008-2014 04 month, in the situation that patient is voluntary, accepted outpatient service postoperative patient 180 examples for medical treatment, wherein minimum 20 years old of age, maximum 78 years old, the course of disease was the shortest 1 year, the longest 20 years; Be divided into matched group and treatment group, two groups of patients in mean age, the course of disease, the state of an illness without significant difference.

2, diagnostic criteria: the Revision endoscopic sinus surgery efficacy assessment standard that 3 months after operation is formulated by otolaryngology branch of Chinese Medical Association, Chinese hals,Nasen und Ohrenheilkunde magazine editorial board.

3, Therapeutic Method:

Matched group: 90 examples, patient after chronic sinusitis nasal endoscope operation, adopts normal saline, dexamethasone and gentamycin liquid flush operation chamber, every day 1 time, within 4 weeks, is 1 course for the treatment of, is used in conjunction 3 courses for the treatment of;

Treatment group: 90 examples, patient after chronic sinusitis nasal endoscope operation, takes the embodiment of the present invention 5, and capsule is every day 2 times, each 2, oral; Within 4 weeks, be 1 course for the treatment of, be used in conjunction 3 courses for the treatment of.

4, clinical efficacy evaluation criteria:

Cure: transference cure, nasal endoscopy Dou Kou is open good, and hole chamber mucosal epithelium, without purulent secretion;

Take a turn for the better: symptom is obviously improved, nasal endoscopy is shown in that partial mucosa region, hole chamber edema, plumpness or granulation tissue form, and have a small amount of purulent secretion;

Invalid: symptom is improved, nasal endoscopy is shown in that the adhesion of art chamber, hole stenostomy or locking, polyp form, and have purulent secretion.

5, clinical effectiveness

Group	Number of cases	Cure	Take a turn for the better	Invalid	Total effective rate
						Treatment group	90	66	21	3	96.7％
Matched group	90	46	22	18	75.6％

6, untoward reaction: therapeutic process is showed no the untoward reaction relevant to medicine.

7, result shows: 5 groups of medications of the embodiment of the present invention 12 weeks, to patient's total effective rate 96.7% after chronic sinusitis nasal endoscope operation, obviously exceed 75.6% of matched group, and cure rate, the effective percentage for the treatment of group all obviously exceed matched group.

Claims (4)

1. the pharmaceutical composition after chronic sinusitis nasal endoscope operation, is characterized in that: this pharmaceutical composition be to be made by the raw material of following weight parts:

Radix Astragali 24-36 part, Poria 24-36 part, Fructus Amomi 10-20 part, Semen Coicis 10-20 part, Rhizoma Atractylodis Macrocephalae 10-20 part, Radix Paeoniae Alba 10-20 part, Herba Pogostemonis 6-14 part, Herba Eupatorii 6-14 part, Rhizoma Acori Graminei 7-13 part, Rhizoma Cimicifugae 7-13 part, Radix Angelicae Dahuricae 7-13 part, Radix Glycyrrhizae Preparata 4-8 part, Pericarpium Citri Reticulatae 2-6 part.

2. the pharmaceutical composition after chronic sinusitis nasal endoscope operation according to claim 1, is characterized in that: this pharmaceutical composition be to be made by the raw material of following weight parts:

Radix Astragali 27-33 part, Poria 27-33 part, Fructus Amomi 12-18 part, Semen Coicis 12-18 part, Rhizoma Atractylodis Macrocephalae 12-18 part, Radix Paeoniae Alba 12-18 part, Herba Pogostemonis 8-12 part, Herba Eupatorii 8-12 part, Rhizoma Acori Graminei 6-12 part, Rhizoma Cimicifugae 6-12 part, Radix Angelicae Dahuricae 6-12 part, Radix Glycyrrhizae Preparata 5-7 part, Pericarpium Citri Reticulatae 3-5 part.

3. the pharmaceutical composition after chronic sinusitis nasal endoscope operation according to claim 1, is characterized in that: this pharmaceutical composition be to be made by the raw material of following weight parts:

30 parts of the Radixs Astragali, 30 parts, Poria, 16 parts of Fructus Amomis, 15 parts of Semen Coiciss, 15 parts of the Rhizoma Atractylodis Macrocephalaes, 15 parts of the Radix Paeoniae Albas, 10 parts of Herba Pogostemoniss, 10 parts of Herba Eupatoriis, 9 parts of Rhizoma Acori Graminei, 9 parts of Rhizoma Cimicifugaes, 9 parts of the Radixs Angelicae Dahuricae, 6 parts of Radix Glycyrrhizae Preparatas, 4 parts of Pericarpium Citri Reticulataes.

4. the application in the medicine of the pharmaceutical composition described in any one after preparation chronic sinusitis nasal endoscope operation in claim 1-3.