CN103893026B - It is a kind of to be used for oral cleaning and the mouthwash of health care - Google Patents
It is a kind of to be used for oral cleaning and the mouthwash of health care Download PDFInfo
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- CN103893026B CN103893026B CN201410127122.7A CN201410127122A CN103893026B CN 103893026 B CN103893026 B CN 103893026B CN 201410127122 A CN201410127122 A CN 201410127122A CN 103893026 B CN103893026 B CN 103893026B
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- mouthwash
- ethanol
- active peptides
- small active
- extract
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- 239000002324 mouth wash Substances 0.000 title claims abstract description 49
- 229940051866 mouthwash Drugs 0.000 title claims abstract description 49
- 238000004140 cleaning Methods 0.000 title claims abstract description 22
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 159
- 108090000765 processed proteins & peptides Proteins 0.000 claims abstract description 50
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 48
- 102000004196 processed proteins & peptides Human genes 0.000 claims abstract description 46
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 claims abstract description 32
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 claims abstract description 32
- XMGQYMWWDOXHJM-UHFFFAOYSA-N limonene Chemical compound CC(=C)C1CCC(C)=CC1 XMGQYMWWDOXHJM-UHFFFAOYSA-N 0.000 claims abstract description 32
- 229940041616 menthol Drugs 0.000 claims abstract description 32
- 239000007968 orange flavor Substances 0.000 claims abstract description 32
- 229960003333 chlorhexidine gluconate Drugs 0.000 claims abstract description 27
- YZIYKJHYYHPJIB-UUPCJSQJSA-N chlorhexidine gluconate Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O.C1=CC(Cl)=CC=C1NC(=N)NC(=N)NCCCCCCNC(=N)NC(=N)NC1=CC=C(Cl)C=C1 YZIYKJHYYHPJIB-UUPCJSQJSA-N 0.000 claims abstract description 27
- 235000011187 glycerol Nutrition 0.000 claims abstract description 24
- CHHHXKFHOYLYRE-UHFFFAOYSA-M 2,4-Hexadienoic acid, potassium salt (1:1), (2E,4E)- Chemical compound [K+].CC=CC=CC([O-])=O CHHHXKFHOYLYRE-UHFFFAOYSA-M 0.000 claims abstract description 23
- 229940069338 potassium sorbate Drugs 0.000 claims abstract description 23
- 239000004302 potassium sorbate Substances 0.000 claims abstract description 23
- 235000010241 potassium sorbate Nutrition 0.000 claims abstract description 23
- 239000004376 Sucralose Substances 0.000 claims abstract description 22
- BAQAVOSOZGMPRM-QBMZZYIRSA-N sucralose Chemical compound O[C@@H]1[C@@H](O)[C@@H](Cl)[C@@H](CO)O[C@@H]1O[C@@]1(CCl)[C@@H](O)[C@H](O)[C@@H](CCl)O1 BAQAVOSOZGMPRM-QBMZZYIRSA-N 0.000 claims abstract description 22
- 235000019408 sucralose Nutrition 0.000 claims abstract description 22
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 20
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 claims abstract description 18
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 claims abstract description 18
- 210000000214 mouth Anatomy 0.000 claims abstract description 18
- 239000000811 xylitol Substances 0.000 claims abstract description 18
- 229960002675 xylitol Drugs 0.000 claims abstract description 18
- 235000010447 xylitol Nutrition 0.000 claims abstract description 18
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 claims abstract description 18
- 239000012153 distilled water Substances 0.000 claims abstract description 10
- 230000000694 effects Effects 0.000 claims abstract description 9
- 230000003110 anti-inflammatory effect Effects 0.000 claims abstract description 4
- 210000004400 mucous membrane Anatomy 0.000 claims abstract description 4
- 230000000844 anti-bacterial effect Effects 0.000 claims abstract description 3
- 238000011282 treatment Methods 0.000 claims abstract description 3
- 239000000284 extract Substances 0.000 claims description 32
- 239000000706 filtrate Substances 0.000 claims description 19
- 238000010438 heat treatment Methods 0.000 claims description 17
- 239000000243 solution Substances 0.000 claims description 13
- 230000006837 decompression Effects 0.000 claims description 11
- 238000002360 preparation method Methods 0.000 claims description 11
- 241000238675 Periplaneta americana Species 0.000 claims description 10
- 239000004519 grease Substances 0.000 claims description 10
- 238000004064 recycling Methods 0.000 claims description 10
- 239000000796 flavoring agent Substances 0.000 claims description 9
- 235000019634 flavors Nutrition 0.000 claims description 9
- 238000010992 reflux Methods 0.000 claims description 9
- 239000012141 concentrate Substances 0.000 claims description 8
- 239000011259 mixed solution Substances 0.000 claims description 7
- SRBFZHDQGSBBOR-IOVATXLUSA-N D-xylopyranose Chemical compound O[C@@H]1COC(O)[C@H](O)[C@H]1O SRBFZHDQGSBBOR-IOVATXLUSA-N 0.000 claims description 6
- 239000000470 constituent Substances 0.000 claims description 5
- 238000005057 refrigeration Methods 0.000 claims description 4
- PYMYPHUHKUWMLA-UHFFFAOYSA-N arabinose Natural products OCC(O)C(O)C(O)C=O PYMYPHUHKUWMLA-UHFFFAOYSA-N 0.000 claims description 3
- SRBFZHDQGSBBOR-UHFFFAOYSA-N beta-D-Pyranose-Lyxose Natural products OC1COC(O)C(O)C1O SRBFZHDQGSBBOR-UHFFFAOYSA-N 0.000 claims description 3
- 208000025865 Ulcer Diseases 0.000 claims description 2
- 238000012856 packing Methods 0.000 claims description 2
- 231100000397 ulcer Toxicity 0.000 claims description 2
- 238000001914 filtration Methods 0.000 claims 3
- HEBKCHPVOIAQTA-NGQZWQHPSA-N d-xylitol Chemical compound OC[C@H](O)C(O)[C@H](O)CO HEBKCHPVOIAQTA-NGQZWQHPSA-N 0.000 claims 2
- 238000000605 extraction Methods 0.000 claims 2
- 239000007788 liquid Substances 0.000 claims 2
- 229960003487 xylose Drugs 0.000 claims 1
- 208000020670 canker sore Diseases 0.000 abstract description 9
- GHXZTYHSJHQHIJ-UHFFFAOYSA-N Chlorhexidine Chemical compound C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 GHXZTYHSJHQHIJ-UHFFFAOYSA-N 0.000 description 8
- 229960003260 chlorhexidine Drugs 0.000 description 8
- 208000030194 mouth disease Diseases 0.000 description 7
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 6
- 239000008103 glucose Substances 0.000 description 6
- 239000000203 mixture Substances 0.000 description 6
- 206010006326 Breath odour Diseases 0.000 description 5
- 241000222122 Candida albicans Species 0.000 description 5
- 241000588724 Escherichia coli Species 0.000 description 5
- 208000032139 Halitosis Diseases 0.000 description 5
- 229940095731 candida albicans Drugs 0.000 description 5
- 241000191967 Staphylococcus aureus Species 0.000 description 4
- 239000002904 solvent Substances 0.000 description 4
- 229940034610 toothpaste Drugs 0.000 description 4
- 239000000606 toothpaste Substances 0.000 description 4
- 230000007774 longterm Effects 0.000 description 3
- 206010061218 Inflammation Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 230000001586 eradicative effect Effects 0.000 description 2
- 235000019441 ethanol Nutrition 0.000 description 2
- 230000004054 inflammatory process Effects 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 2
- 229920000053 polysorbate 80 Polymers 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 230000014860 sensory perception of taste Effects 0.000 description 2
- 150000003384 small molecules Chemical class 0.000 description 2
- 208000024891 symptom Diseases 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- NAOLWIGVYRIGTP-UHFFFAOYSA-N 1,3,5-trihydroxyanthracene-9,10-dione Chemical compound C1=CC(O)=C2C(=O)C3=CC(O)=CC(O)=C3C(=O)C2=C1 NAOLWIGVYRIGTP-UHFFFAOYSA-N 0.000 description 1
- FFRBMBIXVSCUFS-UHFFFAOYSA-N 2,4-dinitro-1-naphthol Chemical compound C1=CC=C2C(O)=C([N+]([O-])=O)C=C([N+]([O-])=O)C2=C1 FFRBMBIXVSCUFS-UHFFFAOYSA-N 0.000 description 1
- FRXSZNDVFUDTIR-UHFFFAOYSA-N 6-methoxy-1,2,3,4-tetrahydroquinoline Chemical compound N1CCCC2=CC(OC)=CC=C21 FRXSZNDVFUDTIR-UHFFFAOYSA-N 0.000 description 1
- 208000010266 Aggressive Periodontitis Diseases 0.000 description 1
- 206010007134 Candida infections Diseases 0.000 description 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 1
- RGHNJXZEOKUKBD-UHFFFAOYSA-N D-gluconic acid Natural products OCC(O)C(O)C(O)C(O)C(O)=O RGHNJXZEOKUKBD-UHFFFAOYSA-N 0.000 description 1
- RGHNJXZEOKUKBD-SQOUGZDYSA-N Gluconic acid Natural products OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O RGHNJXZEOKUKBD-SQOUGZDYSA-N 0.000 description 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 208000007027 Oral Candidiasis Diseases 0.000 description 1
- 229920002690 Polyoxyl 40 HydrogenatedCastorOil Polymers 0.000 description 1
- 241000191940 Staphylococcus Species 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- 241000287411 Turdidae Species 0.000 description 1
- 235000009754 Vitis X bourquina Nutrition 0.000 description 1
- 235000012333 Vitis X labruscana Nutrition 0.000 description 1
- 240000006365 Vitis vinifera Species 0.000 description 1
- 235000014787 Vitis vinifera Nutrition 0.000 description 1
- 230000001133 acceleration Effects 0.000 description 1
- 208000026935 allergic disease Diseases 0.000 description 1
- 230000007815 allergy Effects 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 244000052616 bacterial pathogen Species 0.000 description 1
- 201000003984 candidiasis Diseases 0.000 description 1
- 239000004359 castor oil Substances 0.000 description 1
- 235000019438 castor oil Nutrition 0.000 description 1
- 239000000460 chlorine Substances 0.000 description 1
- 229910052801 chlorine Inorganic materials 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 230000001408 fungistatic effect Effects 0.000 description 1
- 235000012208 gluconic acid Nutrition 0.000 description 1
- 239000000174 gluconic acid Substances 0.000 description 1
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 1
- 239000001963 growth medium Substances 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 230000000474 nursing effect Effects 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 238000011017 operating method Methods 0.000 description 1
- 201000006727 periodontosis Diseases 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- ULWHHBHJGPPBCO-UHFFFAOYSA-N propane-1,1-diol Chemical class CCC(O)O ULWHHBHJGPPBCO-UHFFFAOYSA-N 0.000 description 1
- 238000011321 prophylaxis Methods 0.000 description 1
- -1 rilanit special Chemical compound 0.000 description 1
- 210000003296 saliva Anatomy 0.000 description 1
- 238000013112 stability test Methods 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 238000012549 training Methods 0.000 description 1
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- Cosmetics (AREA)
Abstract
The present invention provides a kind of for oral cleaning and the mouthwash of health care.Each component and its weight are：Small active peptides 0.2% 2%, glycerine 5% 15%, rilanit special 0.5% 2%, chlorhexidine gluconate：0.05% 0.5%, xylitol 2.5% 10%, potassium sorbate 0.1% 0.3%, Sucralose 0.01% 0.03%, menthol 0.025% 0.1%, orange flavor 0.025% 0.1%, ethanol 1% 15%, remaining is distilled water.The mouthwash of the present invention not only has antibacterial and cleaning action to human oral cavity, and small active peptides are used in combination with anti-inflammatory with chlorhexidine gluconate, accelerate the effects such as mucous membrane of mouth reparation, treatment canker sore.
Description
Technical field
The present invention relates to oral cleaning nursing article technical field, especially a kind of gargling for oral cleaning and health care
Water.
Background technology
Common mouth disease has canker sore, periodontosis, carious tooth, thrush, halitosis etc., triggers mouth disease
The reason for be that oral cleaning is incomplete, swill residual provides one for pathogenic bacteria in the oral cavity and free " cultivated
Base ", improve the incidence of disease of mouth disease.
In daily life, people get used to carrying out oral cleaning once in the morning and once at night from toothpaste, in work usually
Make to be not convenient to use toothpaste in environment, but can to make up toothpaste not readily portable and can not use whenever and wherever possible for mouthwash
Shortcoming.For oral cavity, adding the mouthwash of drug ingedient can not only accomplish to carry out cleaning-nursing whenever and wherever possible, pure and fresh oral cavity,
Oral cavity can be protected with prophylactic treatment mouth disease, the Working Life to people is brought convenience.
Patent No. ZL201010239368.5 discloses a kind of gargle of chlorhexidine gluconate, excellent in the gargle
It is chlorhexidine gluconate 1.2: propane diols 50: glycerine 50: polyoxyl 40 hydrogenated castor oil 1 to select component ratio.And glucose
If sour Chlorhexidine is long-term use of, tooth stain can be made easily to deposit what dental surface, the sense of taste is influenceed and be led to RAU, for
Have for the patient of canker sore, if long-term use of chlorhexidine gluconate mouthwash can not only play the work in cleaning oral cavity
With the illness that can also aggravate canker sore on the contrary.
The content of the invention
In order to solve above-mentioned prior art defect, it is an object of the invention to provide one kind can overcome long-term use of grape
Saccharic acid Chlorhexidine can make tooth stain easily deposit what dental surface, the mouthwash for the shortcomings that influenceing the sense of taste and being led to RAU,
It is particularly a kind of not only to have antibacterial and cleaning action to human oral cavity, but also with anti-inflammatory, the reparation of acceleration mucous membrane of mouth, treatment
The effect of canker sore.
It is an object of the invention to provide a kind of for oral cleaning and the mouthwash of health care, particularly a kind of gluconic acid
The mouthwash that Chlorhexidine and small active peptides are used in combination.
Mouthwash of the present invention, its composition and its weight ratio are：
Small active peptides 0.2%~2%, glycerine 5%~15%, rilanit special 0.5%~3%, chlorhexidine gluconate
0.05%~0.5%, xylitol 2.5%~10%, potassium sorbate 0.1%~0.3%, Sucralose 0.01%~0.03%, menthol
0.025%~0.1%, orange flavor 0.025%~0.1%, ethanol 1%~15%
Preferably, the constituent of described mouthwash and its weight ratio are：
Small active peptides 0.5%~2.0%, glycerine 5%-10%, rilanit special 1.5%~2.5%, chlorhexidine gluconate
0.1%~0.3%, xylitol 2.5%-5%, potassium sorbate 0.1%-0.2%, Sucralose 0.01%-0.02%, menthol 0.025%-
0.05%, orange flavor 0.025%-0.05%, ethanol 1%-5%
Further, it is preferable that constituent and its weight ratio of described mouthwash is：
Small active peptides 1.0%, glycerine 10%, rilanit special 2.0%, chlorhexidine gluconate 0.25%, xylitol 5%,
Potassium sorbate 0.3%, Sucralose 0.02%, menthol 0.05%, orange flavor 0.05%, ethanol 5%
Mouthwash of the present invention, is achieved through the following technical solutions：
（1）Small active peptides, glycerine, rilanit special, chlorhexidine gluconate, xylose are weighed by above-mentioned recipe ratio
Alcohol, potassium sorbate, Sucralose, appropriate pure water is added, dissolved by heating.30min is boiled in heating after dissolving.Let cool, as mix
Solution A.
（2）Menthol, orange flavor, the ethanol in formula are weighed, menthol, orange flavor are dissolved in ethanol.Then
It is well mixed, filters with solution A.Filtrate adds distilled water and is settled to corresponding volume.Packing, is produced.
Small active peptides of the present invention derive from American-cockroach-extract, and its preparation process is：
American cockroach is weighed, the alcohol reflux for adding 70-90% extracts 2-3 times, is separately added into 8 times, 6 times, 6 times every time, mistake
Filter, decompression filtrate recycling ethanol.No ethanol flavor is recycled to, 2-10 DEG C or so refrigeration 24-48 hour of concentrate, upper strata grease is used
Filter paper is sucked, and subnatant is centrifuged, and centrifugate is concentrated under reduced pressure, dries, crushed, as American-cockroach-extract, every gram of extract
In containing small active peptides in more than 160mg.
The mouthwash prepared by technical scheme, can clean the swill in oral cavity, while have oral cavity to burst
Ulcer, the patient outcome of halitosis are obvious.Under the double action of chlorhexidine gluconate and small active peptides, to being present in oral cavity
In harmful microorganism such as staphylococcus aureus, Escherichia coli, Candida albicans etc. have it is stronger kill effect, play simultaneously
Antiinflammatory action, the reparation of prevention, mucous membrane of mouth to mouth disease serve certain effect.
The embodiment of form by the following examples, the above of the present invention is made further specifically
It is bright.But the scope that this should not be interpreted as to the above-mentioned theme of the present invention is only limitted to following embodiment.It is all to be wanted based on right of the present invention
The technology that the content for asking secretary to carry is realized belongs to the scope of the present invention.
Embodiment
Embodiment 1 is a kind of for oral cleaning and the mouthwash of health care
Formula：
The rilanit special 2.0% of 1.0% glycerine of small active peptides 10%
The potassium sorbate 0.3% of 0.25% xylitol of chlorhexidine gluconate 5%
The orange flavor 0.05% of 0.02% menthol of Sucralose 0.05%
95% ethanol 5%
Concrete operations：
（1）Small active peptides, glycerine, rilanit special, the glucose described in embodiment 1 are weighed by above-mentioned recipe ratio
Sour Chlorhexidine, xylitol, potassium sorbate, Sucralose, appropriate pure water is added, dissolved by heating.30min is boiled in heating after dissolving.
Let cool, as mixed solution A.
（2）Menthol, orange flavor, 95% ethanol are weighed by recipe ratio, menthol, orange flavor are dissolved in 95% ethanol
In.Then it is well mixed, filters with solution A.Filtrate adds distilled water and is settled to 10000ml, dispenses, produces.
Wherein, the preparation method of small active peptides is as follows：
American cockroach 1000g is weighed, the alcohol reflux for adding 90% extracts 3 times, is separately added into 8 times, 6 times, 6 times every time, mistake
Filter, decompression filtrate recycling ethanol.No ethanol flavor is recycled to, 10 DEG C or so of concentrate refrigerates 48 hours, by upper strata grease filter paper
Suck, subnatant is centrifuged, centrifugate is concentrated under reduced pressure, dries, crushed, as American-cockroach-extract, contains in every gram of extract
Small active peptides are in 196mg.
Embodiment 2 is a kind of for oral cleaning and the mouthwash of health care
Formula：
The rilanit special 2.5% of 2.0% glycerine of small active peptides 15%
The potassium sorbate 0.3% of 0.3% xylitol of chlorhexidine gluconate 10%
The orange flavor 0.1% of 0.03% menthol of Sucralose 0.1%
95% ethanol 15%
Concrete operations：
（1）Small active peptides, glycerine, rilanit special, the glucose described in embodiment 1 are weighed by above-mentioned recipe ratio
Sour Chlorhexidine, xylitol, potassium sorbate, Sucralose, appropriate pure water is added, dissolved by heating.30min is boiled in heating after dissolving.
Let cool, as mixed solution A.
（2）Menthol, orange flavor, 95% ethanol are weighed by recipe ratio, menthol, orange flavor are dissolved in 95% ethanol
In.Then it is well mixed, filters with solution A.Filtrate adds distilled water and is settled to 20000ml, dispenses, produces.
Wherein, the preparation method of small active peptides is as follows：
American cockroach 2000g is weighed, the alcohol reflux for adding 80% extracts 2 times, is separately added into 8 times, 6 times every time, filters,
Decompression filtrate recycling ethanol.No ethanol flavor is recycled to, 2 DEG C or so of concentrate refrigerates 24 hours, upper strata grease is sucked with filter paper,
Subnatant is centrifuged, centrifugate is concentrated under reduced pressure, dries, crushed, as American-cockroach-extract, and small molecule is contained in every gram of extract
Active peptide is in 179mg.
Embodiment 3 is a kind of for oral cleaning and the mouthwash of health care
Formula：
The rilanit special 0.5% of 0.2% glycerine of small active peptides 5%
The potassium sorbate 0.1% of 0.05% xylitol of chlorhexidine gluconate 2.5%
The orange flavor 0.025% of 0.01% menthol of Sucralose 0.025%
95% ethanol 1%
Concrete operations：
（1）Small active peptides, glycerine, rilanit special, the glucose described in embodiment 1 are weighed by above-mentioned recipe ratio
Sour Chlorhexidine, xylitol, potassium sorbate, Sucralose, appropriate pure water is added, dissolved by heating.30min is boiled in heating after dissolving.
Let cool, as mixed solution A.
（2）Menthol, orange flavor, 95% ethanol are weighed by recipe ratio, menthol, orange flavor are dissolved in 95% ethanol
In.Then it is well mixed, filters with solution A.Filtrate adds distilled water and is settled to 80000ml, dispenses, produces.
Wherein, the preparation method of small active peptides is：
American cockroach 2000g is weighed, the alcohol reflux for adding 70% extracts 3 times, is separately added into 8 times, 6 times, 6 times every time, mistake
Filter, decompression filtrate recycling ethanol.No ethanol flavor is recycled to, 10 DEG C or so of concentrate refrigerates 36 hours, by upper strata grease filter paper
Suck, subnatant is centrifuged, centrifugate is concentrated under reduced pressure, dries, crushed, as American-cockroach-extract, contains in every gram of extract
Small active peptides are in 183mg.
Embodiment 4 is a kind of for oral cleaning and the mouthwash of health care
Formula：
The rilanit special 1.5% of 0.5% glycerine of small active peptides 5%
The potassium sorbate 0.2% of 0.1% xylitol of chlorhexidine gluconate 5%
The orange flavor 0.05% of 0.01% menthol of Sucralose 0.05%
95% ethanol 8%
Concrete operations：
（1）Small active peptides, glycerine, rilanit special, the glucose described in embodiment 1 are weighed by above-mentioned recipe ratio
Sour Chlorhexidine, xylitol, potassium sorbate, Sucralose, appropriate pure water is added, dissolved by heating.30min is boiled in heating after dissolving.
Let cool, as mixed solution A.
（2）Menthol, orange flavor, 95% ethanol are weighed by recipe ratio, menthol, orange flavor are dissolved in 95% ethanol
In.Then it is well mixed, filters with solution A.Filtrate adds distilled water and is settled to 40000ml, dispenses, produces.
Wherein, the preparation method of small active peptides is as follows：
American cockroach 3000g is weighed, the alcohol reflux for adding 90% extracts 2 times, is separately added into 8 times, 6 times every time, filters,
Decompression filtrate recycling ethanol.No ethanol flavor is recycled to, 2 DEG C or so of concentrate refrigerates 48 hours, upper strata grease is sucked with filter paper,
Subnatant is centrifuged, centrifugate is concentrated under reduced pressure, dries, crushed, as American-cockroach-extract, and small molecule is contained in every gram of extract
Active peptide is in 175mg.
Embodiment 5 is a kind of for oral cleaning and the mouthwash of health care
Formula：
The rilanit special 3.0% of 2.0% glycerine of small active peptides 10%
The potassium sorbate 0.2% of 0.5% xylitol of chlorhexidine gluconate 5%
The orange flavor 0.025% of 0.03% menthol of Sucralose 0.1%
95% ethanol 15%
Concrete operations：
（1）Small active peptides, glycerine, rilanit special, the glucose described in embodiment 1 are weighed by above-mentioned recipe ratio
Sour Chlorhexidine, xylitol, potassium sorbate, Sucralose, appropriate pure water is added, dissolved by heating.30min is boiled in heating after dissolving.
Let cool, as mixed solution A.
（2）Menthol, orange flavor, 95% ethanol are weighed by recipe ratio, menthol, orange flavor are dissolved in 95% ethanol
In.Then it is well mixed, filters with solution A.Filtrate adds distilled water and is settled to 20000ml, dispenses, produces.
Wherein, the preparation method of small active peptides is as follows：
American cockroach 1000g is weighed, the alcohol reflux for adding 70% extracts 2 times, is separately added into 8 times, 6 times every time, filters,
Decompression filtrate recycling ethanol.No ethanol flavor is recycled to, 10 DEG C or so of concentrate refrigerates 24 hours, upper strata grease is inhaled with filter paper
Go, subnatant is centrifuged, centrifugate is concentrated under reduced pressure, dries, crushed, as American-cockroach-extract, containing small in every gram of extract
Molecular activity peptide is in 170mg.
Embodiment 6 is a kind of for oral cleaning and the mouthwash of health care
Formula：
The rilanit special 2.0% of 1.0% glycerine of small active peptides 10%
The Sucralose 0.02% of 5% potassium sorbate of xylitol 0.3%
The ethanol 5% of the orange flavor of menthol 0.05% 0.05% 95%
Concrete operations：
（1）Small active peptides, glycerine, rilanit special, the xylose described in embodiment 1 are weighed by above-mentioned recipe ratio
Alcohol, potassium sorbate, Sucralose, appropriate pure water is added, dissolved by heating.30min is boiled in heating after dissolving.Let cool, as mix
Solution A.
（2）Menthol, orange flavor, 95% ethanol are weighed by recipe ratio, menthol, orange flavor are dissolved in 95% ethanol
In.Then it is well mixed, filters with solution A.Filtrate adds distilled water and is settled to 10000ml, dispenses, produces.
Wherein, the preparation method of small active peptides is as follows：
American cockroach 3000g is weighed, the alcohol reflux for adding 80% extracts 3 times, is separately added into 8 times, 6 times, 6 times every time, mistake
Filter, decompression filtrate recycling ethanol.No ethanol flavor is recycled to, 5 DEG C or so of concentrate refrigerates 48 hours, upper strata grease is inhaled with filter paper
Go, subnatant is centrifuged, centrifugate is concentrated under reduced pressure, dries, crushed, as American-cockroach-extract, containing small in every gram of extract
Molecular activity peptide is in 185mg.
Embodiment 7 is a kind of for oral cleaning and the mouthwash of health care
Formula：
The chlorhexidine gluconate 0.25% of 10% rilanit special of glycerine 2.0%
The Sucralose 0.02% of 5% potassium sorbate of xylitol 0.3%
The ethanol 5% of the orange flavor of menthol 0.05% 0.05% 95%
Concrete operations：
（1）Glycerine, rilanit special, chlorhexidine gluconate, xylitol, potassium sorbate, three are weighed by above-mentioned recipe ratio
Chlorine sucrose, appropriate pure water is added, dissolved by heating.30min is boiled in heating after dissolving.Let cool, as mixed solution A.
（2）Menthol, orange flavor, 95% ethanol are weighed by recipe ratio, menthol, orange flavor are dissolved in 95% ethanol
In.Then it is well mixed, filters with solution A.Filtrate adds distilled water and is settled to 10000ml, dispenses, produces.
The selection of the solubilizer of embodiment 8 and its content range
In order to increase the stability of heretofore described mouthwash, the purpose of the present embodiment is to filter out this suitable hair
The solubilizer of mouthwash described in bright, increase the stability of mouthwash with this.
This gives two kinds of solubilizer：Tween-80 and rilanit special, Tween-80 is found in result is investigated
The mouthwash prepared when content is 2% is muddy, and is gargled using what 2% rilanit special was under equal conditions prepared
Saliva needs to place for quite a long time, and turbid phenomenon just occurs in solution, and concrete outcome is shown in Table 1：
As seen from Table 1, the solubilizer that can increase the stability of heretofore described mouthwash is hydrogen
Change castor oil, the preferred amount ranges of rilanit special can also be seen that in 1.5%-2.5% by the result in table 1, most preferably
Amount ranges are 2%.
The stability experiment of embodiment 9
The purpose of the present embodiment is with embodiment 1（Contain chlorhexidine gluconate and small active peptides in composition）For
Experimental group, embodiment 6（Small active peptides are comprised only in composition）With embodiment 7（Chlorhexidine gluconate is comprised only in composition）
It is compared for control group, investigates the stability of the mouthwash prepared according to the formula of embodiment 1, come further with this
The feasibility of bright heretofore described mouthwash.Experimental condition：
37 DEG C ± 2 DEG C of temperature, storage is inverted in the medicine stability test case of humidity 65% ± 5%, respectively at the 0th, 4,
8th, sample within 12 weeks, investigate the content of the character of this product, pH value, chlorhexidine gluconate and small active peptides.
Result of the test is shown in Table 2
As seen from Table 2, in the embodiment 1 simultaneously containing small active peptides and chlorhexidine gluconate
Described mouthwash is substantially better than containing only the stability of small active peptides or the mouthwash of chlorhexidine gluconate.
The fungistatic effect of embodiment 10 is examined
The purpose of the present embodiment is to examine according to the mouthwash obtained by above-described embodiment 1-7 method to golden yellow
Staphylococcus, Escherichia coli, Candida albicans kill situation, the effect of to further illustrate heretofore described mouthwash
Effect, concrete operation method are as follows：
Staphylococcus aureus, Escherichia coli, Candida albicans are inoculated in the nutrient broth training handled well respectively
Support in base, after cultivating 18 hours, the mouthwash described in above-described embodiment is added in each culture medium, continues culture to 48 hours
Afterwards, staphylococcus aureus, Escherichia coli, the eradicative rate of Candida albicans are recorded, the results are shown in Table 3
| Staphylococcus aureus | Escherichia coli | Candida albicans | |
| Embodiment 1 | 99% | 98% | 99% |
| Embodiment 2 | 96% | 98% | 97% |
| Embodiment 3 | 93% | 95% | 95% |
| Embodiment 4 | 95% | 93% | 91% |
| Embodiment 5 | 93% | 94% | 96% |
| Embodiment 6（Contrast） | 76% | 70% | 70% |
| Embodiment 7（Contrast） | 80% | 83% | 84% |
It can be seen that embodiment 1-5 to the eradicative rates of three kinds of thalline apparently higher than embodiment 6 and embodiment by result in table 3
7, unexpected result can be obtained by further illustrating chlorhexidine gluconate and small active peptides being used in combination.
Therapeutic effect of the embodiment 11 to canker sore
The purpose of the present embodiment is to heretofore described mouthwash to mouth disease particularly canker sore, oral cavity
The therapeutic effect of inflammation and halitosis is further described.
The operating method of the present embodiment：Randomly select that allergy does not suffer from mouth disease to this product（Canker sore, halitosis,
Bacterial plaque, swelling and aching of gum）Volunteer, the mouthwash prepared using above-described embodiment 1-5, one time 10 milliliters, containing gargling 3-5 point
Clock, continuous observation Oral symptoms, as a result as shown in table 4：
In summary, the mouthwash prepared by formula of the present invention and technical scheme, can effectively improve oral cavity
The symptom of disease particularly canker sore, oral inflammation and halitosis, while solve that toothpaste is not easy to use whenever and wherever possible lacks
Point.
Claims (6)
- It is 1. a kind of for oral cleaning and the mouthwash of health care, it is characterised in that：Constituent that described mouthwash contains and Its percentage by weight is：Small active peptides 0.2%, glycerine 5%, rilanit special 0.5%, chlorhexidine gluconate 0.05%, wood Sugar alcohol 2.5%, potassium sorbate 0.1%, Sucralose 0.01%, menthol 0.025%, orange flavor 0.025%, ethanol 1%, wherein, Described small active peptides derive from American-cockroach-extract, and its preparation process adds 70-90%'s to weigh American cockroach Alcohol reflux extracts 2-3 times, is separately added into 8 times, 6 times, 6 times every time, filtering, decompression filtrate recycling ethanol, is recycled to no ethanol Taste, 2-10 DEG C of refrigeration 24-48 hour of concentrate, upper strata grease is sucked with filter paper, subnatant is centrifuged, centrifugate decompression is dense Contracting, dry, crush, as American-cockroach-extract, containing small active peptides in more than 160mg in every gram of extract.
- It is 2. a kind of for oral cleaning and the mouthwash of health care, it is characterised in that：Constituent that described mouthwash contains and Its percentage by weight is：Small active peptides 0.5%, glycerine 5%, rilanit special 1.5%, chlorhexidine gluconate 0.1%, xylose Alcohol 5%, potassium sorbate 0.2%, Sucralose 0.01%, menthol 0.05%, orange flavor 0.05%, ethanol 8%, wherein, it is described Small active peptides derive from American-cockroach-extract, and to weigh American cockroach, the ethanol for adding 70-90% returns its preparation process Stream extraction 2-3 times, 8 times, 6 times, 6 times are separately added into every time, filtering, decompression filtrate recycling ethanol, is recycled to no ethanol flavor, is concentrated 2-10 DEG C of liquid refrigeration 24-48 hours, upper strata grease is sucked with filter paper, subnatant is centrifuged, centrifugate is concentrated under reduced pressure, dries, Crush, as American-cockroach-extract, containing small active peptides in more than 160mg in every gram of extract.
- It is 3. a kind of for oral cleaning and the mouthwash of health care, it is characterised in that：Constituent that described mouthwash contains and Its percentage by weight is：Small active peptides 1.0%, glycerine 10%, rilanit special 2.0%, chlorhexidine gluconate 0.25%, wood Sugar alcohol 5%, potassium sorbate 0.3%, Sucralose 0.02%, menthol 0.05%, orange flavor 0.05%, ethanol 5%, wherein, it is described Small active peptides derive from American-cockroach-extract, its preparation process adds 70-90% ethanol to weigh American cockroach Refluxing extraction 2-3 times, 8 times, 6 times, 6 times are separately added into every time, filtering, decompression filtrate recycling ethanol, is recycled to no ethanol flavor, it is dense 2-10 DEG C of refrigeration 24-48 hour of contracting liquid, upper strata grease is sucked with filter paper, subnatant centrifuged, centrifugate is concentrated under reduced pressure, done It is dry, crush, as American-cockroach-extract, containing small active peptides in more than 160mg in every gram of extract.
- 4. according to the mouthwash described in claim any one of 1-3, it is characterised in that the preparation method of mouthwash is：（1）By with Side's ratio weighs small active peptides, glycerine, rilanit special, chlorhexidine gluconate, xylitol, potassium sorbate, Sucralose, Appropriate pure water is added, is dissolved by heating, is heated after dissolving and boils 10-50 minutes, let cool, as mixed solution A；（2）Weigh formula In menthol, orange flavor, ethanol, menthol, orange flavor are dissolved in ethanol, are then well mixed with solution A, mistake Filter, filtrate add distilled water and are settled to corresponding volume；Packing, is produced.
- 5. according to the mouthwash described in claim any one of 1-3, it is characterised in that：Described mouthwash has antibacterial to oral cavity And cleaning action, but also there is anti-inflammatory, accelerate mucous membrane of mouth reparation.
- 6. according to the mouthwash described in claim any one of 1-3, it is characterised in that：There is described mouthwash treatment oral cavity to burst The effect of ulcer.
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2016112998A1 (en) * | 2015-05-08 | 2016-07-21 | Curasept Ads S.R.L. | Improved mouthwash preparation |
| CN104983744A (en) * | 2015-07-01 | 2015-10-21 | 重庆登康口腔护理用品股份有限公司 | Oral care composition containing periplaneta americana, oral care products and preparation methods of oral care composition and oral care products |
| CN105125416A (en) * | 2015-09-23 | 2015-12-09 | 北京水木中天植物科学研究院 | Oral fresh collutory |
| CN105434310B (en) * | 2015-12-22 | 2021-02-19 | 广州市娇兰化妆品有限公司 | Application of periplaneta americana active ingredient extract in preparation of cosmetics |
| CN108619069B (en) * | 2018-06-25 | 2021-06-08 | 上海典硕生物科技有限公司 | Denture disinfectant and preparation method thereof |
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| CN109010098A (en) * | 2018-10-23 | 2018-12-18 | 郑州吉尔康消毒制品有限公司 | Antimicrobial mouthwash and preparation method thereof |
| CN109771340A (en) * | 2019-03-29 | 2019-05-21 | 上海涵博生物科技有限公司 | A kind of breath freshening is spraying |
| CN110314110A (en) * | 2019-06-04 | 2019-10-11 | 中国人民解放军第四军医大学 | A kind of effervescent tablet type mouthwash and preparation method thereof |
| CN110327246A (en) * | 2019-08-12 | 2019-10-15 | 青岛博智汇力生物科技有限公司 | A kind of mouthwash containing marine oligosaccharide |
| CN110680780A (en) * | 2019-08-21 | 2020-01-14 | 广州市尚昇生物科技有限公司 | Thyme mouthwash oil and preparation method thereof |
| CN110664745A (en) * | 2019-11-15 | 2020-01-10 | 重庆希尔安药业有限公司 | Solution preparation and preparation method thereof |
| CN110664651A (en) * | 2019-11-16 | 2020-01-10 | 许帅辉 | Composition for treating oral mucosa repair and preparation method thereof |
| CN112121037A (en) * | 2020-09-27 | 2020-12-25 | 安婕妤化妆品科技股份有限公司 | A disinfectant product composition |
| CN113499272A (en) * | 2021-09-05 | 2021-10-15 | 广州市九叶化妆品有限公司 | Chlorhexidine gluconate-containing mouthwash and preparation method thereof |
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