CN103877554B - Pharmaceutical composition for treating heart disease and preparation method and use thereof - Google Patents

Abstract

The invention provides a pharmaceutical composition for treating heart disease. The pharmaceutical composition is a medicament prepared from the following raw material medicines in parts by weight: 30-40 parts of rehmannia, 30-40 parts of rhodiola rosea, 6-8 parts of pseudo-ginseng, 6-8 parts of ginseng, 10-13 parts of flax seed, 10-13 parts of angelica, 6-8 parts of donkey-hide gelatin, 10-13 parts of ophiopogon japonicus, 6-8 parts of fructus aurantii, 9-12 parts of cassia twig, 10-13 parts of poria with hostwood, 9-12 parts of polygala tenuifolia, 9-12 parts of fresh ginger, 10-13 parts of jujube and 8-12 parts of licorice. The invention further provides a preparation method and use of the pharmaceutical composition. The pharmaceutical composition provided by the invention has an accurate formula, can effectively treat such heart diseases (or alleviate the illness) as atrial fibrillation, viral myocarditis, coronary heart disease and the like, avoids the toxic and side effects of pharmaceutical chemicals, and provides a new choice for clinical medication.

Description

One kind treats cardiopathic pharmaceutical composition and its production and use

Technical field

The present invention relates to one kind treats cardiopathic pharmaceutical composition.Belong to drug world.

Background technology

Heart disease is the common circulation system disease of a class, and concrete disease is a lot.The circulatory system is by heart, blood vessel and regulation Sanguimotor neurohumor organizational composition, circulation system disease is also referred to as cardiovascular disease, belongs to common disease, in internal disease For common, very harmful.As vital myocarditis may occur in which heart failure, cardiogenic shock and sudden death, and doctor trained in Western medicine is at present simultaneously No specific treatment medicine.For another example one of maximum harm of atrial fibrillation i.e. cerebral apoplexy, non-valvular heart disease patient's cerebral apoplexy occurs Rate is 5.6 times of normal person, and valvular heart disease atrial fibrillation incidence of stroke is 17.6 times of normal person, and the post-stroke that atrial fibrillation causes Really even more serious, disability rate up to 25% about, the death rate is also up to 25%.

, after defeating the fiendishness disease such as smallpox, the plague, malaria, the lethal cause of disease of arrangement first is by coronary disease at present for the mankind Disease is replaced.The whole world has several hundred million people attacked by coronary heart disease now, and only the U.S. just has more than 100,000,000 heart to be disturbed by coronary heart disease, and And coronary heart disease also has twin brothers: the vascular sclerosis that high cholesterol leads to, thus coronary heart disease or cerebrovascular sclerosis lead fire Rope.With the raising of up-to-dateness and people's living standard, the quickening of rhythm of life, diet structure is changed with habits and customs Become, the heart disease such as coronary heart disease also will constantly rise.At present, China has become as aging degree highest country, and the elderly The principal pathogenetic colony of cardiovascular and cerebrovascular disease, simultaneously as work and life stress increase, move less, environmental pollution etc. former Cause, heart disease also assumes the trend of rejuvenation, for hypertension, only in China students in middle and primary schools of 6～18 years old, hypertension The incidence of disease has just reached 8%, and a lot of young men occur in that coronary heart disease myocardial infarction, and have is also therefore and dead.Heart disease this " human health first killer " wreak havoc and large area takes place frequently, force who also specially to set up the special tackling key problem in association center, seek to control Treat good medicine.

Doctor trained in Western medicine to more than angiocardiopathy using drug therapy such as cardiac stimulant, expansion of blood vessels and diuresis, such as monobel, disappear the heart Bitterly, calcium ion antagonist class antianginal drug (nifedipine), selective coronary dilation agent and antiviral agent (Dipyridamole), β ARBs (Celiprolol), segondin, inderal, these medicines are all acute disease medications, and these medicines are also with as follows Drawback: 1. toxic and side effect: in addition to gastrointestinal reaction, allergic reaction, poisoning manifestations, Central nervous, hepatic and renal function also have infringement, clothes Medicine reaction symptom up to nausea,vomiting,diarrhea, gastrointestinal discomfort, poor appetite, flush, palpitaition, tachycardia, position Low blood pressure, headache, dizziness, tired, insomnia, cutaneous anaphylaxis, fash or even exfoliative dermatitis, muscle spasmus, myasthenia, flesh shake Quiver, coldness of extremities, itch, tear reduce, are in a very depressed state, rubefaction, fash, burning heat sensation, perspire even collapse, long-term taking The reaction such as drug resistance can be produced.2. many crowds can not take: if any allergies person, glaucoma, coronary occlusion and thrombus Formation, cerebral hemorrhage, increased intracranial pressure, cardiogenic shock, ° or ° atrioventricular block, severe heart failure, hole aroused in interest Too slow, Bronchial Asthmas, have allergies, diabetes, congestive heart failure, pulmonary emphysema or nonallergic bronchitis, Dyshepatia, hypothyroidism, Raynaud's syndrome or other peripheral angiopathy, renal hypofunction, activity ulcer The patients and pregnant woman, lactication woman, children etc. such as hemorrhage of digestive tract, hemophilia or the thrombopenia that sick or other reasonses cause are all Prohibit clothes.However, the patient suffering from angiocardiopathy generally requires long-term prescription, and cover all kinds of different crowds.The good news is, Treatment by Chinese herbs heart disease has had shown that its unique superiority, and Chinese Herbs are definite, lasting, and bad reaction is few, especially with remote Phase satisfactory effect and be widely used in clinic.

Substantial amounts of result of study and clinical practice prove, Chinese medicine with its tolerance preferable, toxic and side effect is little the features such as display Go out its unique advantage, Chinese medicine occupies extremely important position in this market and is in strong position it might even be possible to say, wherein A topmost reason is that Western medicine has absolute predominance in terms for the treatment of angiocardiopathy unlike antibioticses medicine, Belong to the not significant kind of curative effect.And Chinese medicine is then because it has, and evident in efficacy, reliable and stable, the advantage such as have no toxic side effect, more More paid close attention to by medical investigator and extensive patients.

Clinically, the Chinese patent drug of some treatment angiocardiopathies existing, but belong to the kind of " emergency " more, and " emergency " Medicine has more serious toxic and side effect, and the most very, Chinese patent drug is no exception for Western medicine, " helps meet an urgent need ", and should not grow at all when only anxious Long term usage is used.As storax pill for treating coronary heart disease contains the compositions such as frankincense, borneol, dutchmanspipe root, santal, levant storax oil；Another kind compound is red Ginseng piece also contains borneol etc..These fragrance dissipate composition and consume very much body qi-blood-body fluid of hurting sb.'s feelings, and long term usage is unfavorable on the contrary to the state of an illness.Further, It is known that angiocardiopathy generally requires to take medicine all the life, and after " emergency ", need badly and continue to take effective treatment, And this continual cure being necessary for following up after " emergency ", it is only treatment that is most important, effecting a permanent cure, but clinically, just Just Western medicine lacks the effective kind of this respect, and the Chinese patent drug of correlation also relative deficiency.Medicine of the present invention, then exactly this mesh Front clinically still not enough effective Chinese patent drug kind.

Content of the invention

The technical scheme is that providing one kind treats cardiopathic pharmaceutical composition, present invention also offers this medicine The preparation method of compositions and purposes.

The present invention relates to one kind treats cardiopathic pharmaceutical composition, it is by the bulk drug preparation of following weight proportioning The preparation becoming:

30～40 parts of glutinous rehmannia, 30～40 parts of rhodiola root, 6～8 parts of pseudo-ginseng, 6～8 parts of ginseng, 10～13 parts of flax benevolence, Radix Angelicae Sinensis 10～13 parts, 6～8 parts of donkey-hide gelatin, 10～13 parts of the tuber of dwarf lilyturf, 6～8 parts of Fructus Aurantii, 9～12 parts of cassia twig, 10～13 parts of fushen, polygala root 9～ 12 parts, 9～12 parts of ginger, 10～13 pieces of date, 8～12 parts of Radix Glycyrrhizae.

Further, it is the preparation being prepared from by the bulk drug of following weight proportioning:

30 parts of glutinous rehmannia, 30 parts of rhodiola root, 6 parts of pseudo-ginseng, 6 parts of ginseng, 10 parts of flax benevolence, 10 parts of Radix Angelicae Sinensis, 6 parts of donkey-hide gelatin, the tuber of dwarf lilyturf 10 parts, 6 parts of Fructus Aurantii, 9 parts of cassia twig, 10 parts of fushen, 9 parts of polygala root, 9 parts of ginger, 10 pieces of date, 12 parts of Radix Glycyrrhizae, 400 parts of yellow rice wine or 30 White wine 300 below spending part.

Further, described glutinous rehmannia is prepared rhizome of rehmannia: the melange of radix rehmanniae recen=24:6；Described Radix Glycyrrhizae is Radix Glycyrrhizae (processed with honey).

Pharmaceutical composition of the present invention is by the primary crude drug powder of described bulk drug, or the water of bulk drug or/and organic solvent Extract is active component, adds that pharmaceutically acceptable auxiliary material or complementary composition are prepared into the preparation pharmaceutically commonly used.

Wherein, described organic solvent is edible wine, ethanol or hydrous ethanol.Wherein, edible wine includes white wine or yellow rice wine.

Wherein, described preparation be tablet, capsule, soft capsule, granule, pill, pill, oral liquid, sublingual Spray, injection.

Present invention also offers the preparation method of this pharmaceutical composition, it comprises the steps:

A, weigh the bulk drug of weight proportion；

B, take each bulk drug, extracted for solvent with water, white wine or/and yellow rice wine, extract adds pharmaceutically acceptable Auxiliary material or complementary composition be prepared into pharmaceutically commonly use preparation.

Present invention also offers this pharmaceutical composition treats the purposes in cardiopathic medicine in preparation.

Wherein, described medicine is treatment auricular fibrillation, vital myocarditis, the medicine of coronary heart disease.

Have been accepted as " organic conception ", " diagnosis and treatment based on an overall analysis of the illness and the patient's condition " at present, " compound use ", " compound compatibility medication is such as used military forces " are the traditional Chinese medical science Most scientific maximally effective several big advantages, wherein " compound compatibility medication is such as used military forces " are the original theories of traditional Chinese medicine of very science.In Each medicine tight compatibility all linked with one another as arrayed troops for battle in doctor's prescription, is that it is better than the effective means of western medicine formula.The traditional Chinese medical science Prescription theory thinks, each prescription, not only needs to select the appropriate compatibility of suitable medicine according to etiology and pathogenesis, also should meet simultaneously The basic structure of prescription, i.e. the prescription compatibility theory of " monarch, minister, help, make ", the prescription compatibility of so-called " monarch, minister, help, make " it is simply that It sets up the scientific matching on the comprehensive judgement basis to the disease interpretation of the cause, onset and process of an illness.Middle medical square passes through too many levels, Mutiple Targets are integrated The biological mechanism adjusting, to this Western medicine (chemical drugs) no special efficacy kind and the larger cardiac patient of toxic and side effect is adjusted Control, can obtain than Western medicine more preferably, the therapeutic effect that has no toxic side effect of more green natural, and this curative effect be built upon above-mentioned in On the original theoretical accurate instruction of doctor's tradition, of the present invention group of Founder have followed this principle.

Pharmaceutical composition of the present invention reuses glutinous rehmannia nourishing yin and nourishing blood with multiple arteries and veins the dominator of QI as monarch drug in a prescription.Rhodiola root, Radix Notoginseng powder, ginseng Fill the post of left hall ministerial drug and supplement healthy tendency auxiliary monarch drug in a prescription, as a means of source of generating QI and blood, so that the work(benefit of strong the spleen transforming the nutrients into blood is write.Donkey-hide gelatin, Radix Angelicae Sinensis, fiber crops Benevolence, tuber of dwarf lilyturf blood-nourishing in sweet flavor, join glutinous rehmannia then grow the heart-yin, nourishing heart blood, congested arteries and veins power higher, therefore send as right hall ministerial drug.Assistant with cassia twig, Ginger, Fructus Aurantii, pure mellow wine pungent row temperature is led to, warm heart-yang, promoting blood circulation, and one can make qi and blood smooth to help arteries and veins gas to continue, second all savoury Grow greasy product and obtain this and then grow and oiliness, thus be transferred to left adjutant.Fushen, polygala root, date, calm peace aligning god, date also may be used Assist a ruler in governing a country the gas that heart spleen taken a tonic or nourishing food to build up one's health by left hall ministerial drug, therefore be transferred to right wing adjutant.Radix Glycyrrhizae (processed with honey) simply, multiple arteries and veins of not only can fostering the spirit of nobility, sour-sweet herbs nourishing yin, Cooperation ministerial drug, can coordinating the drug actions of a prescription be also to make, therefore with for making medicine.Prescription of the present invention is grown and oiliness, temperature and not dry, make cloudy hemapodium and blood Arteries and veins fills, yang-energy heart Maitong again, and qi and blood is abundant, and negative and positive are in harmonious proportion, then sufferer rehabilitates naturally.

Above each group flavour of a drug post is clearly demarcated, complements each other, has given full play to the exclusive compound compatibility medication of traditional Chinese medicine such as Row army structure the formation as sexology research methodology marrow of analyzing mentally, the heart diseases such as atrial fibrillation, vital myocarditis are had and well control Therapeutic effect, can effectively alleviate its symptom, be that clinical application provides a kind of new selection.

Specific embodiment

The preparation of embodiment 1 medicine of the present invention

Take 30 grams of glutinous rehmannia, 30 grams of rhodiola root, 6 grams of pseudo-ginseng, 6 grams of ginseng, 10 grams of flax benevolence, 10 grams of Radix Angelicae Sinensis, 6 grams of donkey-hide gelatin, wheat 10 grams of the winter of door, 6 grams of Fructus Aurantii, 9 grams of cassia twig, 10 grams of fushen, 9 grams of polygala root, 9 grams of ginger, 10 pieces of date, 12 grams of honey-fried licorice root.Each flavour of a drug Weigh according to quantity, pseudo-ginseng is ground as superfine end, donkey-hide gelatin molten, and Radix Glycyrrhizae processs Huang with honey, and date is broken brokenly, the water of the amount of filling up and yellow rice wine (or white Wine) remaining each medicine of being decocted first in addition to pseudo-ginseng, donkey-hide gelatin, decoct about 12 minutes to 15 minutes again after boiling, collect decocting liquid, be blended into pseudo-ginseng The donkey-hide gelatin of powder and molten, mixes thoroughly；The dregs of a decoction add water method such as and decoct 2 times, merge each decocting liquid, obtain final product decoction.

The preparation of embodiment 2 pharmaceutical composition of the present invention

Take glutinous rehmannia 40g, rhodiola root 30g, pseudo-ginseng 6g, ginseng 6g, flax benevolence 10g, Radix Angelicae Sinensis 10g, donkey-hide gelatin 6g, tuber of dwarf lilyturf 10g, trifoliate orange Shell 6g, cassia twig 9g, fushen 10g, polygala root 9g, ginger 9g, 10 pieces of date, Radix Glycyrrhizae 8g.Other medicinal materials in addition to donkey-hide gelatin, with yellow rice wine Less than 400g or 30 degree white wine 300g and suitable quantity of water Soakage extraction, collect extract, add molten donkey-hide gelatin, add suitable paste Essence, soluble starch, pelletize, obtain final product granule.

The preparation of embodiment 3 pharmaceutical composition of the present invention

Take glutinous rehmannia 30g, rhodiola root 40g, pseudo-ginseng 8g, ginseng 8g, flax benevolence 13g, Radix Angelicae Sinensis 13g, donkey-hide gelatin 8g, tuber of dwarf lilyturf 13g, trifoliate orange Shell 8g, cassia twig 12g, fushen 13g, polygala root 12g, ginger 12g, 13 pieces of date, Radix Glycyrrhizae 12g.Each flavour of a drug weigh according to quantity, pseudo-ginseng grind for Superfine end, donkey-hide gelatin molten, Radix Glycyrrhizae processs Huang with honey, and date is broken brokenly, and the water of the amount of filling up and yellow rice wine (or white wine) are decocted first except pseudo-ginseng, donkey-hide gelatin Outside remaining each medicine, after boiling again decoct about 12 minutes to 15 minutes, collect decocting liquid, be blended into Notoginseng Root and molten Ah Glue, mixes thoroughly；The dregs of a decoction add water method such as and decoct 2 times, merge each decocting liquid, concentrate, add suitable dextrin, soluble starch, Pelletize, compressing tablet, obtain final product tablet.

The preparation of embodiment 4 medicine of the present invention

Take 30 grams of glutinous rehmannia, 30 grams of rhodiola root, 6 grams of pseudo-ginseng, 6 grams of ginseng, 10 grams of flax benevolence, 10 grams of Radix Angelicae Sinensis, 6 grams of donkey-hide gelatin, wheat 10 grams of the winter of door, 6 grams of Fructus Aurantii, 9 grams of cassia twig, 10 grams of fushen, 9 grams of polygala root, 9 grams of ginger, 10 pieces of date, 12 grams of honey-fried licorice root.Take each former Material medicine, is initially charged 95% alcohol extract 2 times, merges that alcohol extract is standby, and the dregs of a decoction add water to cook 2 times, alcohol extract reclaim after ethanol with water Decocting liquid merges, and concentrates, and adds appropriate amount of auxiliary materials, prepares pill.

The preparation of embodiment 5 pharmaceutical composition of the present invention

The decoction of Example 1 preparation, standing, take supernatant, after concentration, dry, pulverize, standby；Take poly- second two in right amount Alcohol 4000, after melting, above-mentioned medicinal powder is added in melting matrix, is incubated at 75-85 DEG C；Using various pill dripping machine, drip inside/outside Footpath and a speed appropriateness, are instilled in dimethicone, collect dripping pill, obtain final product pill.

Prove beneficial effects of the present invention below by way of pharmacodynamics test.

Clinic (outpatient service) treatment of test example medicine of the present invention

(1) patient profiles are accepted for medical treatment

According to inventor's clinical practice of more than 30 year, with the drug therapy atrial fibrillation of embodiment 1, vital myocarditis, coronary disease The cardiacs such as disease 19, obtain more satisfied curative effect.Treatment time: according to each conditions of patients weight, age size, The difference of the concrete conditions such as physical strength and difference, typically at 5 weeks～10 months about.Patient age and sex scope are Young, middle aged, old age all has, and there are men and women for sex.

(2) treat standard

Recovery from illness: symptom is wholly absent, electrocardiogram etc. checks no abnormality seen, or life activity is freely, can recover normal work.

Evident in efficacy: symptom substantially mitigates, there is certain degree to improve simultaneously on inspection, or can resume work and daily life Activity.

There is certain effect: patients symptomatic has mitigated, or slightly improve on inspection, but work is with ADL still not As normal when.

Invalid: symptom remains unchanged, do not improve completely.

(3) treatment method

1st, the made decoction of embodiment 1, every bu is taken for 3 times, and serveing on 7 is a course for the treatment of, can be discontinued 1 between the course for the treatment of and the course for the treatment of Day, if suffer from other new diseases such as diarrhoea etc. also should be discontinued.

2nd, note and science conditioning daily life, in accordance with some necessary points for attention, such as:

(1) as belonged to patients with atrial fibrillation, should give up smoking, restriction is drunk, limit or without caffeine, some patients may avoid containing There are material such as tea, coffee, cola and some over-the-counter medicationses of caffeine.Application may the medicine containing stimulus with caution (these materials may promote the irregular rhythm of the heart).

(2) vital myocarditis is it is initially noted that evade virus, preventing viral illness.Multiple viruses all can cause this disease, its In to cause the virus infection of enteron aisle and the infection of the upper respiratory tract the most common.Coxsackie virus a group, Coxsackie virus b group, Ai Ke (echo) virus, poliovirus are common cause myocarditis virus, and wherein Coxsackie virus b group virus is topmost disease Poison.Other are as adenovirus, influenza, parainfluenza virus, measles virus, mumps virus, japanese encephalitis virus, hepatitis viruse, band Shape herpesviral, cytomegalovirus and AIDS virus etc., all should notice and evade.

(3) coronary heart disease then answers active treatment " three high ": hypertension；(T-CHOL is too high or low-density lipoprotein for dyslipidemia Cholesterol is too high, triglycerides is too high, HDL-C is too low)；Hyperglycaemia (diabetes).And it is overweight (fertile Fat).The outbreak of coronary heart disease often with seasonal variations, excited, physical exertion increases, is satiated with food, a large amount of smoking and drink etc. relevant, Therefore bad life style should be corrected, including smoking, unreasonable meals (higher fatty acid, high cholesterol, high heat etc.), lack muscular labor Dynamic, excessive consumption of alcohol, and bad socio-psychological factor.And evade the pathogen relevant with infection, such as cytomegalovirus, pneumonia clothing Substance, helicobacter pylori etc..

(4) various heart diseases all should be lain up as early as possible, lightening heart load, enters easy to digest and rich proteinaceous food.

(4) treatment results

With medicine composite for curing related heart disease of the present invention (atrial fibrillation, vital myocarditis, coronary heart disease) between thirties years Men and women patient counts 19, obtains preferable curative effect, symptom can mitigate or be wholly absent or substantially disappear typically within 5 weeks Lose, nurse one's health daily life by above-mentioned science, sincerely abide by points for attention, excellent effect can be received.

By above-mentioned treatment standard, in 19 patients, there are 8 recoveries from illness, cure rate reaches 42.1%；5 evident in efficacy, reaches 26.3%；3 have certain effect, account for 15.8%；3 DeGrains (invalid), account for 15.8%.Total effective rate reaches 84.2%.

Model case 1

Patient, female, 17 years old, because of heating, slight chill, rhinorrhea, bodily pain, then pharyngalgia, cough and remove certain outpatient clinic, Doctor examines as influenza, and symptom after taking medicine has mitigated.But more than ten in the future, dizziness, expiratory dyspnea, palpitaition, uncomfortable in chest, pareordia occur again Secret anguish, then anxious certain people's hospital therapy past.By the item visual inspection such as virology, blood biochemical, electrocardiogram, echocardiogram Look into, examine as vital myocarditis (middle severe).When patient is to examine, as before, the complexion of sight loses China, lip color is thin, and speech is or not symptom Raise, feeble, the vigor in no youth, pink tongue matter is done and more modest, kank.Inquire further, just knowing its menstrual cycle Often, only measure few color light, this menses mistake.Examine so far, syndrome is bright, (embodiment 1 is made then to give pharmaceutical composition of the present invention Standby), if advising it to meet menstrual period, temporarily it is discontinued, and sternly abide by the method for administration of above-mentioned " treatment method " its " 1 " and the science conditioning of " 2 " And points for attention.Patient abides by and advises, clothes only two weeks, and it is good greatly to have seen, adheres to clothes by 5 weeks, symptom, sign, electrocardiogram all turn completely Often reform, follow-up has no recurrence.

Model case 2

Patient, man, 47 years old, patient was because of palpitating speed (170 beats/min), and disorder of beating, and feels more tired, tired, shortness of breath (expiratory dyspnea), chest discomfort (having constriction), dizzy etc., examined after Electrocardioscopy as Idiopathic atrial fibrillation (atrium Vibration).Please tcm diagnosis and treatment, observation: the thin void of body is thin, pale complexion, the few tongue of tongue light, send out less and grey；Ask that (news) examines: few gas is lazy Speech, severe palpilation, symptom is as above；Diagnosis: arteries and veins delays weak and Shi Youyi stops, but irregular, is nodus.After examining, issue medicine of the present invention Compositions, advise it to prepare by embodiment 1 as method, and the science of the method for administration and " 2 " of sternly abiding by above-mentioned " treatment method " its " 1 " is adjusted Reason and points for attention, and adhere to taking.Patient abides by and advises clothes to the 7th week (of short duration drug withdrawal twice, withdraws two days every time for some reason therebetween), Symptom substantially completely eliminates, and on inspection, has recovered sinus rhythm (normal cardiac rhythm), electrocardiogram has greatly improvement, and follow-up has no recurrence.

In sum, drug regimen composition formula of the present invention is precise and appropriate, can effectively treatment atrial fibrillation, vital myocarditis, coronary heart disease Etc. heart disease (or alleviating its patient's condition), and avoid the toxic and side effect that chemical drugs have, be that clinical application provides one kind newly Selection.

Claims (10)

1. one kind treat cardiopathic pharmaceutical composition it is characterised in that: it be by following weight proportioning bulk drug prepare and The preparation becoming:

30 parts of glutinous rehmannia, 30 parts of rhodiola root, 6 parts of pseudo-ginseng, 6 parts of ginseng, 10 parts of flax benevolence, 10 parts of Radix Angelicae Sinensis, 6 parts of donkey-hide gelatin, 10 parts of the tuber of dwarf lilyturf, 6 parts of Fructus Aurantii, 9 parts of cassia twig, 10 parts of fushen, 9 parts of polygala root, 9 parts of ginger, 10 pieces of date, 12 parts of Radix Glycyrrhizae.

2. pharmaceutical composition according to claim 1 it is characterised in that: described glutinous rehmannia be prepared rhizome of rehmannia: radix rehmanniae recen=24:6's Melange；Described Radix Glycyrrhizae is Radix Glycyrrhizae (processed with honey).

3. pharmaceutical composition according to claim 1 it is characterised in that: it be by described bulk drug primary crude drug powder, Or the water of bulk drug or/and extractive with organic solvent are active component, add pharmaceutically acceptable auxiliary material or complementary composition It is prepared into the preparation pharmaceutically commonly used.

4. pharmaceutical composition according to claim 3 it is characterised in that: described organic solvent is edible wine, ethanol or contain Water-ethanol.

5. pharmaceutical composition according to claim 4 it is characterised in that: described edible wine be white wine or yellow rice wine.

6. the pharmaceutical composition according to claim 1-5 any one it is characterised in that: described preparation be tablet, glue Wafer, granule, pill, oral liquid, sub-lingual spray, injection.

7. pharmaceutical composition according to claim 6 it is characterised in that: described capsule is soft capsule；Described pill It is pill.

8. a kind of method preparing the pharmaceutical composition described in claim 1-7 any one, it comprises the steps:

A, weigh the bulk drug of weight proportion；

B, take each bulk drug, extracted for solvent with water, white wine or/and yellow rice wine, extract adds pharmaceutically acceptable auxiliary Material or complementary composition are prepared into the preparation pharmaceutically commonly used.

9. the pharmaceutical composition described in claim 1-7 any one treats the purposes in cardiopathic medicine in preparation.

10. purposes according to claim 9 it is characterised in that: described medicine be treatment auricular fibrillation, viral cardiac muscle The scorching, medicine of coronary heart disease.