CN103845690A - Medicament for treating geriatric depression - Google Patents

Abstract

The invention relates to a medicament for treating geriatric depression. The medicament provided by the invention is developed by applying traditional Chinese medicine basic theory and comprises the following active pharmaceutical ingredients of traditional Chinese medicines: pilose asiabell root, membranous milkvetch root, spine date seed, Chinese thorowax root, Chinese angelica, Szechuan lovage rhizome, white paeony root, turmeric root-tuber, costustoot, liquorice root and the like. The medicament can be prepared into various formulations through modern conventional preparation methods. The medicament has the effects of dispersing stagnated liver qi, relieving qi stagnation, regulating qi-flowing, resolving food stagnation and nourishing heart for tranquillization, and is used for treating the depression caused by stagnation of liver qi and deficiency of both heart and spleen. The medicament is clinically applied for many years, and the efficacy is significant.

Description

A kind of medicine for the treatment of depression in old age

Technical field

The present invention relates to a kind of Chinese medicine composition for the treatment of depression in old age, more specifically say that one has dispersing the stagnated live-QI to relieve the stagnation of QI, regulating the flow of vital energy is stagnant, be used for the treatment of depression of liver-QI, the heart the is insufficiency of the spleen weak and depression that causes.Belong to field of medicaments.

Background technology

Depression is a kind of affective disorder disease of outbreak repeatedly that continues, the mental symptom such as main manifestations is that mental state is low, hebetude, retardation of thinking, self evaluation are too low, simultaneously can be with appetite and hyposexuality, the somatizations such as speech action minimizing, fatiguability, insomnia, dizziness, headache.In motherland's medical science, belong to the categories such as " melancholia ", hysteria, " being insomnia ", " cardiopalmus ", depression in old age is wherein a part of.Show according to update, the rank in China's mental disorder in the total burden of disease leaps to the first, and the patients with depression in Shanghai has accounted for total population more than 5%.In north America region and EU countries, depression can cause the annual loss up to 1,500 hundred million dollars.Meanwhile, the homicide rate of patients with depression is up to 25%.That is to say, depression both can affect people's work, life, can jeopardize again patient's life.Therefore strengthen the understanding to depression, strengthen the research of antidepressants, guarantee that Community health's development has very important meaning, and will produce larger economic benefit and social benefit.

The traditional Chinese medical science there is no depression name of disease, but because of its joyless unhappy, lie awake all night, the anxious feature of pondering over, therefore can belong to strongly fragrant disease, the dirty category such as dry.Alleviation and the rehabilitation of Chinese medicine to depression now produced good curative effect.The traditional Chinese medical science thinks, depression is many hinders because of feelings will, and morbidity and liver relation is the closest, and next relates to the heart, spleen.The strong fortune of liver mistake, the heart are become homeless foster, and disorder of QI and blood is the main pathogenesis of primary disease.

Medicine of the present invention is take Chinese medical theory as guidance, as Therapeutic Principle, through systematic study, science compatibility, developed a kind of medicine for the treatment of depression in old age take " dispersing the stagnated live-QI to relieve the stagnation of QI, regulating the flow of vital energy are stagnant, tranquilizing by nourishing the heart ".

Summary of the invention

Object of the present invention is just to provide a kind of medicine for the treatment of depression in old age.

In order to realize object of the present invention, the invention provides a kind of Chinese medicine composition of Cure of depression, it is the medicament of being made up according to weight portion meter of following raw materials according:

Radix Codonopsis 10-20 part Radix Astragali 20-30 part Semen Ziziphi Spinosae 10-20 part Radix Bupleuri 12-25 part

Radix Angelicae Sinensis 8-15 part Rhizoma Chuanxiong 10-15 part Radix Paeoniae Alba 5-15 part Radix Curcumae 10-20 part

Radix Aucklandiae 5-15 part Radix Glycyrrhizae 5-8 part.

Preferably, Chinese medicine composition of the present invention is the medicament of being made up according to weight portion meter of following raw materials according:

20 parts of 15 parts of Radix Bupleuri of 25 parts of Semen Ziziphi Spinosaes of 15 parts of Radixs Astragali of Radix Codonopsis

15 parts of 10 portions of Radix Curcumaes of 12 portions of Radix Paeoniae Albas of 12 parts of Rhizoma Chuanxiongs of Radix Angelicae Sinensis

6 parts, 8 portions of Radix Glycyrrhizaes of the Radix Aucklandiae.

Why the present invention selects above-mentioned medical material as raw material, is because they have following effect:

Radix Codonopsis: invigorating the spleen and replenishing QI, spleen invigorating lung benefiting, for deficiency of the spleen and lung, the cardiopalmus of breathing hard, anorexia and loose stool, dyspnea due to deficiency cough, interior-heat is quenched one's thirst.

The Radix Astragali: invigorating QI to consolidate the body surface resistance, diuresis poison holding, evacuation of pus, expelling pus and promoting granulation.Weak for the deficiency of vital energy, anorexia and loose stool, sinking of QI of middle-JIAO, chronic diarrhea proctoptosis, the metrorrhagia of having blood in stool, exterior deficiency spontaneous perspiration, deficiency of vital energy edema, carbuncle is difficult bursts, and burst and do not hold back for a long time, blood deficiency dull yellowish colored skin, interior-heat is quenched one's thirst; Chronic nephritis proteinuria, diabetes.The invigorating middle warmer of processed with honey Radix Astragali QI invigorating.Weak for the deficiency of vital energy, anorexia and loose stool.

Semen Ziziphi Spinosae: tonifying liver, mind calming, arresting sweating, promotes the production of body fluid.For restlessness of asrhenia type and insomnia, palpitation with fear dreaminess, the empty hyperhidrosis of body, Tianjin wound is thirsty.

Radix Bupleuri: evacuate and bring down a fever, soothing liver-QI, yang invigorating.For cold, fever, alternate attack of chill and fever, malaria, distending pain in the chest and hypochondrium, menoxenia, sub-official's prolapsus, proctoptosis.

Radix Angelicae Sinensis: enrich blood and invigorate blood circulation, menstruction regulating and pain relieving, loosening bowel to relieve constipation.For blood deficiency and yellow complexion, dizzy cardiopalmus, menoxenia, amenorrhea dysmenorrhea, asthenia cold abdominalgia, dryness of the intestine constipation, rheumatic arthralgia, injury from falling down, ulcer sores.

Rhizoma Chuanxiong: blood-activating and qi-promoting, wind-expelling pain-stopping.For menoxenia, amenorrhea dysmenorrhea, note of the ancient Chinese abdominal mass stomachache, the twinge of the breast side of body, tumbling and swelling, headache, rheumatic arthralgia.

The Radix Paeoniae Alba: suppressing the hyperactive liver pain relieving, nourishing blood for regulating menstruation, astringing YIN to stop sweating.Be used for having a headache dizzy, hypochondriac pain, stomachache, limb pain twin, blood deficiency and yellow complexion, menoxenia, spontaneous perspiration, night sweat.

Radix Curcumae: regulating qi to disperse stagnation, heart fire-clearing upset-relieving, promoting the function of the gallbladder to alleviate jaundice.For amenorrhea dysmenorrhea, chest and abdomen swelling and pain, twinge, calentura coma, epilepsy is gone mad, jaundice dark coloured urine.

The Radix Aucklandiae: promoting the circulation of QI to relieve pain, strengthening the spleen to promote digestion.For breast gastral cavity distending pain, heavy after dysentery, food stagnation does not disappear, anorexia.The real intestinal antidiarrheal of Radix Aucklandiae (roasted).Stomachache is used for having loose bowels.

Radix Glycyrrhizae: invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, gastral cavity abdomen, the anxious pain of extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.

Described pharmacy optimization is tablet, capsule, granule.When Chinese medicine composition of the present invention is made preparation, can adopt the conventional method in existing pharmaceutical field to produce, when needs, can add various pharmaceutically acceptable carriers.Described carrier comprises diluent, excipient, filler, binding agent, lubricant, disintegrating agent, promotion absorbent, surfactant of pharmaceutical field routine etc.Chinese medicine composition of the present invention is in the time making oral formulations, and selectable filler has: starch, Icing Sugar, dextrin, microcrystalline Cellulose, lactose, solubilization starch, mannitol etc.; Selectable binding agent has: sodium carboxymethyl cellulose, starch slurry, ethyl cellulose, gelling starch etc.; Selectable disintegrating agent has: dried starch, polyvinylpolypyrrolidone, cross-linking sodium carboxymethyl cellulose, carboxymethyl starch sodium, low replacement carboxy-propyl cellulose sodium etc.; Selectable lubricant has: magnesium stearate, Pulvis Talci, sodium lauryl sulphate, micropowder silica gel etc.

Chinese medicine composition provided by the invention has that dispersing the stagnated live-QI to relieve the stagnation of QI, regulating the flow of vital energy are stagnant, effect of tranquilizing by nourishing the heart, for because of depression of liver-QI, and the depression that the heart is insufficiency of the spleen due to weak.

The specific embodiment

With embodiment, a kind of medicine for the treatment of depression in old age of the present invention is further described below, this will contribute to the present invention and effect thereof further to understand, and embodiment does not limit protection scope of the present invention, and its protection domain is decided by claim.

Embodiment 1

12 parts of 10 parts of Radix Bupleuri of 20 parts of Semen Ziziphi Spinosaes of 10 parts of Radixs Astragali of Radix Codonopsis

10 parts of 5 portions of Radix Curcumaes of 10 portions of Radix Paeoniae Albas of 8 parts of Rhizoma Chuanxiongs of Radix Angelicae Sinensis

5 parts, 5 portions of Radix Glycyrrhizaes of the Radix Aucklandiae

Embodiment 2

25 parts of 20 parts of Radix Bupleuri of 30 parts of Semen Ziziphi Spinosaes of 20 parts of Radixs Astragali of Radix Codonopsis

20 parts of 15 portions of Radix Curcumaes of 15 portions of Radix Paeoniae Albas of 15 parts of Rhizoma Chuanxiongs of Radix Angelicae Sinensis

8 parts, 15 portions of Radix Glycyrrhizaes of the Radix Aucklandiae

Embodiment 3

20 parts of 15 parts of Radix Bupleuri of 25 parts of Semen Ziziphi Spinosaes of 15 parts of Radixs Astragali of Radix Codonopsis

15 parts of 10 portions of Radix Curcumaes of 12 portions of Radix Paeoniae Albas of 12 parts of Rhizoma Chuanxiongs of Radix Angelicae Sinensis

6 parts, 8 portions of Radix Glycyrrhizaes of the Radix Aucklandiae

The therapeutic effect of Chinese medicine composition of the present invention to depression:

Typical case: Zheng, man, 70 years old, medical on March 18th, 2010, disease is seen: before half a year, gradually felt dizzy, poor memory, cardiopalmus, insomnia, the dreaminess of sleeping night, kind the doubting of thinking much, susceptible to fear is easily frightened, paroxysmal sweating, poor appetite Mental fatigue, abdominal distention after meal, gastral cavilty portion sense of discomfort, be difficult to describe, lustreless complexion, deficiency of QI with disinclination to talk, pale tongue, white and thin fur, thready and weak pulse.Belong to melancholy impairing the spleen, insufficiency of generating and transforming QI and blood, Radix Codonopsis 15g, Radix Astragali 25g, Semen Ziziphi Spinosae 15g, Radix Bupleuri 20g, Radix Angelicae Sinensis 12g, Rhizoma Chuanxiong 12g, Radix Paeoniae Alba 10g, Radix Curcumae 15g, Radix Aucklandiae 8g, Radix Glycyrrhizae 6g; Take five doses, the dreaminess of sleeping at insomnia, night is clearly better, five doses of transference cures of following the service, state of an illness recovery from illness.

Claims (3)

1. treat a medicine for depression in old age, it is characterized in that being prepared from by the crude drug processing of following weight parts:

Radix Codonopsis 10-20 part Radix Astragali 20-30 part Semen Ziziphi Spinosae 10-20 part Radix Bupleuri 12-25 part

Radix Angelicae Sinensis 8-15 part Rhizoma Chuanxiong 10-15 part Radix Paeoniae Alba 5-15 part Radix Curcumae 10-20 part

Radix Aucklandiae 5-15 part Radix Glycyrrhizae 5-8 part.

2. a kind of medicine for the treatment of depression in old age according to claim 1, is characterized in that being prepared from by the crude drug processing of following weight parts:

20 parts of 15 parts of Radix Bupleuri of 25 parts of Semen Ziziphi Spinosaes of 15 parts of Radixs Astragali of Radix Codonopsis

15 parts of 10 portions of Radix Curcumaes of 12 portions of Radix Paeoniae Albas of 12 parts of Rhizoma Chuanxiongs of Radix Angelicae Sinensis

6 parts, 8 portions of Radix Glycyrrhizaes of the Radix Aucklandiae.

3. a kind of medicine for the treatment of depression in old age described in one of them according to claim 1 or 2, is characterized in that, preparation is capsule, tablet, granule.